STT3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.49572089
2Golgi transport vesicle coating (GO:0048200)8.49572089
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.93886019
4signal peptide processing (GO:0006465)5.33593594
5protein retention in ER lumen (GO:0006621)5.03879419
6COPII vesicle coating (GO:0048208)4.99899653
7sequestering of metal ion (GO:0051238)4.44585862
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.13242456
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.12199266
10folic acid-containing compound biosynthetic process (GO:0009396)4.12027866
11positive regulation of nuclease activity (GO:0032075)4.07739709
12ribosome assembly (GO:0042255)3.86492166
13regulation of nuclease activity (GO:0032069)3.81612212
14endoplasmic reticulum unfolded protein response (GO:0030968)3.78190335
15cellular response to unfolded protein (GO:0034620)3.70165854
16UDP-N-acetylglucosamine metabolic process (GO:0006047)3.62031037
17cellular response to topologically incorrect protein (GO:0035967)3.55395337
18ER-nucleus signaling pathway (GO:0006984)3.48127439
19vesicle coating (GO:0006901)3.39175930
20protein maturation by protein folding (GO:0022417)3.36338404
21establishment of integrated proviral latency (GO:0075713)3.34934646
22ER overload response (GO:0006983)3.31825885
23desmosome organization (GO:0002934)3.18949819
24* protein N-linked glycosylation via asparagine (GO:0018279)3.17826578
25proteasome assembly (GO:0043248)3.15829219
26* peptidyl-asparagine modification (GO:0018196)3.15331086
27tRNA aminoacylation (GO:0043039)3.05041494
28amino acid activation (GO:0043038)3.05041494
29response to endoplasmic reticulum stress (GO:0034976)3.01803492
30exocrine pancreas development (GO:0031017)2.99272838
31ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.97297602
32IMP biosynthetic process (GO:0006188)2.95042224
33regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.94985712
34hemidesmosome assembly (GO:0031581)2.94889399
35lactate metabolic process (GO:0006089)2.93245784
36* protein N-linked glycosylation (GO:0006487)2.90605861
37cellular response to vitamin D (GO:0071305)2.90395504
38pteridine-containing compound biosynthetic process (GO:0042559)2.89530474
39response to unfolded protein (GO:0006986)2.87974274
40L-serine transport (GO:0015825)2.87886760
41keratan sulfate catabolic process (GO:0042340)2.82425244
42mitotic sister chromatid segregation (GO:0000070)2.78295857
43response to topologically incorrect protein (GO:0035966)2.78083815
444-hydroxyproline metabolic process (GO:0019471)2.77289368
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.76526925
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76526925
47dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.74928357
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74248802
49regulation of translational termination (GO:0006449)2.74119185
50regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.73100828
51collagen fibril organization (GO:0030199)2.72598752
52peptide catabolic process (GO:0043171)2.71993969
53establishment of viral latency (GO:0019043)2.71804669
54ER to Golgi vesicle-mediated transport (GO:0006888)2.71525721
55nucleobase biosynthetic process (GO:0046112)2.70744760
56tetrahydrofolate metabolic process (GO:0046653)2.70045898
57nucleotide-sugar biosynthetic process (GO:0009226)2.69741871
58non-recombinational repair (GO:0000726)2.69664269
59double-strand break repair via nonhomologous end joining (GO:0006303)2.69664269
60proline biosynthetic process (GO:0006561)2.65928203
61nuclear pore organization (GO:0006999)2.65046251
62nucleotide-sugar metabolic process (GO:0009225)2.61822832
63nucleobase-containing small molecule interconversion (GO:0015949)2.60059137
64nuclear pore complex assembly (GO:0051292)2.56701845
65peptide hormone processing (GO:0016486)2.56147714
66sister chromatid segregation (GO:0000819)2.55359681
67endocrine pancreas development (GO:0031018)2.54882749
68IMP metabolic process (GO:0046040)2.54878062
69mitotic metaphase plate congression (GO:0007080)2.54872110
70zinc ion transport (GO:0006829)2.54833091
71protein autoprocessing (GO:0016540)2.52254737
72metaphase plate congression (GO:0051310)2.51851291
73regulation of mitotic spindle organization (GO:0060236)2.51578288
74chaperone-mediated protein folding (GO:0061077)2.51339505
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.50311195
76regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.50122482
77DNA unwinding involved in DNA replication (GO:0006268)2.49617979
78regulation of metalloenzyme activity (GO:0048552)2.48651466
79histone-serine phosphorylation (GO:0035404)2.48626315
80mitotic nuclear envelope disassembly (GO:0007077)2.47103117
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.46848212
82protein localization to kinetochore (GO:0034501)2.45776308
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.43901974
84L-serine metabolic process (GO:0006563)2.43384593
85positive regulation of actin filament depolymerization (GO:0030836)2.43292573
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.43026107
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.41200625
88zinc ion transmembrane transport (GO:0071577)2.40861041
89formation of translation preinitiation complex (GO:0001731)2.40119745
90regulation of cellular amino acid metabolic process (GO:0006521)2.38163112
91apoptotic cell clearance (GO:0043277)2.38096490
92regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.38022287
93purine nucleobase biosynthetic process (GO:0009113)2.37280046
94chondrocyte proliferation (GO:0035988)2.35682568
95long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.35605144
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.35369782
97tricarboxylic acid cycle (GO:0006099)2.34812091
98antigen processing and presentation of endogenous antigen (GO:0019883)2.34473699
99type B pancreatic cell development (GO:0003323)2.33283476
100positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.32590602
101positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.32590602
102positive regulation of mitotic sister chromatid separation (GO:1901970)2.32590602
103regulation of translational elongation (GO:0006448)2.31820543
104peptidyl-proline hydroxylation (GO:0019511)2.30723153
105negative regulation of ligase activity (GO:0051352)2.30001886
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.30001886
107misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.28925444
108lipopolysaccharide biosynthetic process (GO:0009103)2.28649019
109cellular response to vitamin (GO:0071295)2.28643859
110mitotic sister chromatid cohesion (GO:0007064)2.28497367
111mitotic chromosome condensation (GO:0007076)2.28361844
112membrane disassembly (GO:0030397)2.27596879
113nuclear envelope disassembly (GO:0051081)2.27596879
114pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.27431372
115UMP biosynthetic process (GO:0006222)2.27431372
116pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.27431372
117UMP metabolic process (GO:0046049)2.27431372
118telomere maintenance via semi-conservative replication (GO:0032201)2.26410410
119retina vasculature morphogenesis in camera-type eye (GO:0061299)2.25768014
120folic acid-containing compound metabolic process (GO:0006760)2.25741876
121cell redox homeostasis (GO:0045454)2.21659614
122skin morphogenesis (GO:0043589)2.19657549
123pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.17735990
124pore complex assembly (GO:0046931)2.16231513
125protein hydroxylation (GO:0018126)2.15250843
126production of molecular mediator involved in inflammatory response (GO:0002532)2.12811005
127negative regulation of glycoprotein biosynthetic process (GO:0010561)2.12724443
128cell adhesion mediated by integrin (GO:0033627)2.11892433
129regulation of translational fidelity (GO:0006450)2.11866022
130antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.11415335
131maintenance of protein localization in organelle (GO:0072595)2.10347582
132negative regulation of fatty acid transport (GO:2000192)2.08677705
133DNA strand elongation involved in DNA replication (GO:0006271)2.08153644
134chaperone mediated protein folding requiring cofactor (GO:0051085)2.07627974
135regulation of spindle organization (GO:0090224)2.04201876
136glandular epithelial cell development (GO:0002068)2.04107889
137pteridine-containing compound metabolic process (GO:0042558)2.03229106
138viral mRNA export from host cell nucleus (GO:0046784)2.01139201
139translesion synthesis (GO:0019985)1.99422739
140folic acid metabolic process (GO:0046655)1.97528160
141Golgi organization (GO:0007030)1.97395948
142DNA strand elongation (GO:0022616)1.97267333
143pyrimidine nucleoside monophosphate metabolic process (GO:0009129)1.95986364
144glandular epithelial cell differentiation (GO:0002067)1.94913157
145cellular response to glucose starvation (GO:0042149)1.94531510
146SRP-dependent cotranslational protein targeting to membrane (GO:0006614)1.94452877
147L-alpha-amino acid transmembrane transport (GO:1902475)1.94293422
148tRNA aminoacylation for protein translation (GO:0006418)1.91248709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13083409
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.33117139
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.98509253
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.90645835
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.76404814
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70764118
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63044491
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53499802
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.52798060
10GATA1_22025678_ChIP-Seq_K562_Human2.51798243
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.31591628
12ELK1_19687146_ChIP-ChIP_HELA_Human2.24620290
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.17272816
14ZNF263_19887448_ChIP-Seq_K562_Human2.14696837
15AR_21909140_ChIP-Seq_LNCAP_Human2.14116665
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.11713965
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09765704
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04339973
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01892909
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01073701
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92688084
22CLOCK_20551151_ChIP-Seq_293T_Human1.90707046
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.89594826
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88297005
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79732554
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72470116
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72259386
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.68143659
29VDR_23849224_ChIP-Seq_CD4+_Human1.67855653
30* TFEB_21752829_ChIP-Seq_HELA_Human1.67412812
31* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65176995
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64744944
33* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61020027
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60549275
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60067630
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59303788
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.58860085
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58736151
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.58432747
40* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56561260
41* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55852883
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55733510
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55261755
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55127409
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55020904
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.53078312
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53030894
48DCP1A_22483619_ChIP-Seq_HELA_Human1.52437892
49* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52403529
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48878547
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48811835
52FOXP3_21729870_ChIP-Seq_TREG_Human1.46880817
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46409179
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46056886
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45042550
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44765589
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43802660
58GABP_19822575_ChIP-Seq_HepG2_Human1.43644629
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41735572
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40967817
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40500935
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38809847
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38174812
64* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37607217
65* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36481580
66XRN2_22483619_ChIP-Seq_HELA_Human1.35454804
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34356500
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30937819
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29985793
70* MYC_22102868_ChIP-Seq_BL_Human1.28339971
71* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25846382
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24737423
73SPI1_23547873_ChIP-Seq_NB4_Human1.23642952
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23524627
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23501123
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22366428
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22244679
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22085188
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21680040
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20367383
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.19196341
82KDM5A_27292631_Chip-Seq_BREAST_Human1.18939302
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.18247895
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17336630
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16193104
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15202138
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.13637650
88* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13443735
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11305523
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10364655
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09285839
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08240579
93* MYB_26560356_Chip-Seq_TH2_Human1.07676686
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07253067
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06819684
96CHD1_26751641_Chip-Seq_LNCaP_Human1.06702915
97SOX17_20123909_ChIP-Seq_XEN_Mouse1.06645078
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.04876074
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04609184
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03310275
101TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02051582
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02038927
103BRD4_25478319_ChIP-Seq_HGPS_Human1.01388053
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01271952
105GATA6_25053715_ChIP-Seq_YYC3_Human1.01022278
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00956256
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00622828
108ELF5_23300383_ChIP-Seq_T47D_Human1.00256589
109PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00033131
110ATF3_27146783_Chip-Seq_COLON_Human0.99935578
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99506719
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99262402
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98317992
114TTF2_22483619_ChIP-Seq_HELA_Human0.97854082
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97785321
116MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97290791
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96966928
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96966928
119WT1_19549856_ChIP-ChIP_CCG9911_Human0.96256973
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95746563
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95710126
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94511202
123* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94388206
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94085809
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93925895
126* MYB_26560356_Chip-Seq_TH1_Human0.93863742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.92301731
2MP0010234_abnormal_vibrissa_follicle3.53426688
3MP0006054_spinal_hemorrhage3.35603489
4MP0002877_abnormal_melanocyte_morpholog3.01079567
5MP0003941_abnormal_skin_development2.44967088
6MP0003950_abnormal_plasma_membrane2.43311192
7MP0003693_abnormal_embryo_hatching2.33033143
8MP0010352_gastrointestinal_tract_polyps2.12273715
9MP0005503_abnormal_tendon_morphology2.11775834
10MP0005275_abnormal_skin_tensile2.04086369
11MP0003705_abnormal_hypodermis_morpholog1.99311616
12MP0003300_gastrointestinal_ulcer1.98332316
13MP0004264_abnormal_extraembryonic_tissu1.90834230
14MP0005220_abnormal_exocrine_pancreas1.90710540
15MP0005623_abnormal_meninges_morphology1.76241786
16MP0003195_calcinosis1.66226364
17MP0003566_abnormal_cell_adhesion1.66001346
18MP0008007_abnormal_cellular_replicative1.63775154
19MP0004957_abnormal_blastocyst_morpholog1.63709067
20MP0000013_abnormal_adipose_tissue1.58712994
21MP0004272_abnormal_basement_membrane1.56767465
22MP0003806_abnormal_nucleotide_metabolis1.56128164
23MP0003183_abnormal_peptide_metabolism1.51688878
24MP0009384_cardiac_valve_regurgitation1.51411592
25MP0005023_abnormal_wound_healing1.50582343
26MP0003283_abnormal_digestive_organ1.50150716
27MP0002396_abnormal_hematopoietic_system1.49331918
28MP0005058_abnormal_lysosome_morphology1.46081397
29MP0010307_abnormal_tumor_latency1.45264022
30MP0003279_aneurysm1.44352242
31MP0001661_extended_life_span1.38825091
32MP0010368_abnormal_lymphatic_system1.33397036
33MP0002896_abnormal_bone_mineralization1.33262606
34MP0002933_joint_inflammation1.30648801
35MP0010094_abnormal_chromosome_stability1.29993679
36MP0005408_hypopigmentation1.28071426
37MP0002254_reproductive_system_inflammat1.26860773
38MP0001944_abnormal_pancreas_morphology1.25667244
39MP0001849_ear_inflammation1.25330455
40MP0002938_white_spotting1.23753438
41MP0002060_abnormal_skin_morphology1.23371147
42MP0010678_abnormal_skin_adnexa1.21162525
43MP0003786_premature_aging1.20863773
44MP0003718_maternal_effect1.20808114
45MP0001299_abnormal_eye_distance/1.20533196
46MP0005076_abnormal_cell_differentiation1.20418213
47MP0000537_abnormal_urethra_morphology1.19781332
48MP0002693_abnormal_pancreas_physiology1.19546183
49MP0001243_abnormal_dermal_layer1.18619956
50MP0003077_abnormal_cell_cycle1.15237949
51MP0001533_abnormal_skeleton_physiology1.13893942
52MP0003172_abnormal_lysosome_physiology1.13062941
53MP0002139_abnormal_hepatobiliary_system1.11745211
54MP0000358_abnormal_cell_content/1.11364104
55MP0001958_emphysema1.11300147
56MP0004233_abnormal_muscle_weight1.10338416
57MP0000858_altered_metastatic_potential1.08313815
58MP0002084_abnormal_developmental_patter1.06335749
59MP0003937_abnormal_limbs/digits/tail_de1.06008374
60MP0010030_abnormal_orbit_morphology1.04410259
61MP0000490_abnormal_crypts_of1.04249066
62MP0003123_paternal_imprinting1.04171317
63MP0008057_abnormal_DNA_replication1.03911794
64MP0003795_abnormal_bone_structure1.03607134
65MP0005257_abnormal_intraocular_pressure1.03448788
66MP0003385_abnormal_body_wall1.02384255
67MP0002166_altered_tumor_susceptibility1.01522405
68MP0003186_abnormal_redox_activity1.00662034
69MP0003436_decreased_susceptibility_to1.00204744
70MP0004808_abnormal_hematopoietic_stem1.00187360
71MP0003868_abnormal_feces_composition1.00030369
72MP0005508_abnormal_skeleton_morphology0.99396294
73MP0000647_abnormal_sebaceous_gland0.98397865
74MP0001666_abnormal_nutrient_absorption0.97864256
75MP0005390_skeleton_phenotype0.97606213
76MP0005395_other_phenotype0.96622691
77MP0005365_abnormal_bile_salt0.95947136
78MP0002085_abnormal_embryonic_tissue0.95391160
79MP0001542_abnormal_bone_strength0.94913600
80MP0001216_abnormal_epidermal_layer0.94077033
81MP0000762_abnormal_tongue_morphology0.93061529
82MP0001881_abnormal_mammary_gland0.91938006
83MP0000627_abnormal_mammary_gland0.91457096
84MP0000163_abnormal_cartilage_morphology0.90873713
85MP0005501_abnormal_skin_physiology0.90124528
86MP0003252_abnormal_bile_duct0.90023426
87MP0000465_gastrointestinal_hemorrhage0.89769877
88MP0003111_abnormal_nucleus_morphology0.88323873
89MP0003943_abnormal_hepatobiliary_system0.88254620
90MP0002928_abnormal_bile_duct0.87659623
91MP0005197_abnormal_uvea_morphology0.87329787
92MP0005171_absent_coat_pigmentation0.86637655
93MP0009333_abnormal_splenocyte_physiolog0.86303870
94MP0003942_abnormal_urinary_system0.86263634
95MP0005165_increased_susceptibility_to0.86208648
96MP0005367_renal/urinary_system_phenotyp0.85079124
97MP0000516_abnormal_urinary_system0.85079124
98MP0001730_embryonic_growth_arrest0.84787408
99MP0005187_abnormal_penis_morphology0.84588402
100MP0002115_abnormal_skeleton_extremities0.84150945
101MP0009053_abnormal_anal_canal0.83817741
102MP0004197_abnormal_fetal_growth/weight/0.83724859
103MP0002111_abnormal_tail_morphology0.83386717
104MP0003315_abnormal_perineum_morphology0.83351971
105MP0001915_intracranial_hemorrhage0.82309476
106MP0009643_abnormal_urine_homeostasis0.81435509
107MP0000432_abnormal_head_morphology0.80757134
108MP0000003_abnormal_adipose_tissue0.80222631
109MP0002113_abnormal_skeleton_development0.80190906
110MP0000350_abnormal_cell_proliferation0.79925767
111MP0002295_abnormal_pulmonary_circulatio0.79564834
112MP0002697_abnormal_eye_size0.78785744
113MP0002086_abnormal_extraembryonic_tissu0.78592349
114MP0000377_abnormal_hair_follicle0.78575672
115MP0009672_abnormal_birth_weight0.78111997
116MP0010386_abnormal_urinary_bladder0.77835626
117MP0000767_abnormal_smooth_muscle0.77164910
118MP0002168_other_aberrant_phenotype0.77058860
119MP0001835_abnormal_antigen_presentation0.76797282
120MP0003755_abnormal_palate_morphology0.76424083
121MP0009780_abnormal_chondrocyte_physiolo0.76409320
122MP0005384_cellular_phenotype0.75718655
123MP0000534_abnormal_ureter_morphology0.75630630
124MP0002796_impaired_skin_barrier0.75440980
125MP0004134_abnormal_chest_morphology0.74890811
126MP0000598_abnormal_liver_morphology0.73927543
127MP0003984_embryonic_growth_retardation0.71886209
128MP0004947_skin_inflammation0.71401763
129MP0005084_abnormal_gallbladder_morpholo0.71346453
130MP0000613_abnormal_salivary_gland0.71263653
131MP0002088_abnormal_embryonic_growth/wei0.71054812
132MP0003724_increased_susceptibility_to0.70609491
133MP0002419_abnormal_innate_immunity0.70517690
134MP0008932_abnormal_embryonic_tissue0.70036077
135MP0004782_abnormal_surfactant_physiolog0.69971817
136MP0000428_abnormal_craniofacial_morphol0.68133253
137MP0000477_abnormal_intestine_morphology0.66393579
138MP0001845_abnormal_inflammatory_respons0.66101962
139MP0005380_embryogenesis_phenotype0.65896904
140MP0001672_abnormal_embryogenesis/_devel0.65896904
141MP0005464_abnormal_platelet_physiology0.65765818
142MP0002998_abnormal_bone_remodeling0.65593181
143MP0002006_tumorigenesis0.65547278
144MP0010155_abnormal_intestine_physiology0.65143003
145MP0002080_prenatal_lethality0.63448733
146MP0009697_abnormal_copulation0.63387979
147MP0001697_abnormal_embryo_size0.63278112
148MP0008058_abnormal_DNA_repair0.62961396

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)4.23783443
2Premature rupture of membranes (HP:0001788)3.80554254
3Protrusio acetabuli (HP:0003179)3.70048666
4Abnormality of the intrinsic pathway (HP:0010989)3.22976743
5Hypoglycemic coma (HP:0001325)3.17327869
6Abnormality of glycolysis (HP:0004366)2.97237250
7Epiphyseal dysplasia (HP:0002656)2.96452346
8Hypoglycemic seizures (HP:0002173)2.95630171
9Asymmetry of the thorax (HP:0001555)2.92146872
10Hyperinsulinemic hypoglycemia (HP:0000825)2.84619067
11Thoracolumbar scoliosis (HP:0002944)2.84006150
12Beaking of vertebral bodies (HP:0004568)2.82140751
13Abnormal foot bone ossification (HP:0010675)2.80312760
14Cardiovascular calcification (HP:0011915)2.78593169
15Aortic dissection (HP:0002647)2.67464668
16Vascular calcification (HP:0004934)2.63373764
17Aortic aneurysm (HP:0004942)2.55955973
18Increased serum pyruvate (HP:0003542)2.53574579
19Short nail (HP:0001799)2.53427724
20Metaphyseal cupping (HP:0003021)2.50971479
21Soft skin (HP:0000977)2.50927292
22Symptomatic seizures (HP:0011145)2.49796980
23Pancreatic islet-cell hyperplasia (HP:0004510)2.48818761
24Thrombocytosis (HP:0001894)2.46254379
25Abnormality of the pancreatic islet cells (HP:0006476)2.45732189
26Abnormality of endocrine pancreas physiology (HP:0012093)2.45732189
27Orthostatic hypotension (HP:0001278)2.42641257
28Abnormality of the anterior horn cell (HP:0006802)2.42464065
29Degeneration of anterior horn cells (HP:0002398)2.42464065
30Platyspondyly (HP:0000926)2.41915418
31Hypokinesia (HP:0002375)2.40797967
32Arterial tortuosity (HP:0005116)2.37909860
33Abnormal gallbladder physiology (HP:0012438)2.37782715
34Cholecystitis (HP:0001082)2.37782715
35Hyperglycemia (HP:0003074)2.35941472
36Vascular tortuosity (HP:0004948)2.35225249
37Mucopolysacchariduria (HP:0008155)2.33039359
38Urinary glycosaminoglycan excretion (HP:0003541)2.33039359
39Microglossia (HP:0000171)2.32346114
40Abnormality of the common coagulation pathway (HP:0010990)2.31743959
41Vacuolated lymphocytes (HP:0001922)2.29663325
4211 pairs of ribs (HP:0000878)2.29219220
43Abnormality of carpal bone ossification (HP:0006257)2.26825933
44Pterygium (HP:0001059)2.25893132
45Abnormal tarsal ossification (HP:0008369)2.24748433
46Abnormality of methionine metabolism (HP:0010901)2.24635864
47Peritonitis (HP:0002586)2.24459639
48Spondylolisthesis (HP:0003302)2.23488202
49Abnormal delivery (HP:0001787)2.23395608
50Abnormality of dentin (HP:0010299)2.22459335
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19886559
52Broad face (HP:0000283)2.19652352
53Entropion (HP:0000621)2.18474519
54Fragile skin (HP:0001030)2.18473612
55Osteolytic defects of the hand bones (HP:0009699)2.18278558
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.18278558
57Wormian bones (HP:0002645)2.17973629
58Small epiphyses (HP:0010585)2.17368515
59Cupped ribs (HP:0000887)2.17099929
60Abnormal pancreas size (HP:0012094)2.16356734
61Delayed epiphyseal ossification (HP:0002663)2.15771244
62Irregular epiphyses (HP:0010582)2.15764268
63Atrophic scars (HP:0001075)2.15691211
64Blue sclerae (HP:0000592)2.14711481
65Nonimmune hydrops fetalis (HP:0001790)2.14507255
66Abnormality of the acetabulum (HP:0003170)2.14003167
67Dysostosis multiplex (HP:0000943)2.13898496
68Flat capital femoral epiphysis (HP:0003370)2.13612999
69Vertebral compression fractures (HP:0002953)2.13154840
70Breech presentation (HP:0001623)2.11463939
71Hypoplasia of the odontoid process (HP:0003311)2.08947009
72Overlapping toe (HP:0001845)2.07641458
73Ependymoma (HP:0002888)2.06775397
74Ankle contracture (HP:0006466)2.06196146
75Nuclear cataract (HP:0100018)2.05501258
76Abnormality of the umbilical cord (HP:0010881)2.03014126
77Back pain (HP:0003418)1.99719463
78Abnormalities of placenta or umbilical cord (HP:0001194)1.98677799
79Cerebral aneurysm (HP:0004944)1.98364647
80Missing ribs (HP:0000921)1.97373383
81Type I transferrin isoform profile (HP:0003642)1.97217544
82Hypobetalipoproteinemia (HP:0003563)1.96678374
83Generalized aminoaciduria (HP:0002909)1.96079950
84Cutaneous melanoma (HP:0012056)1.95834400
85Syringomyelia (HP:0003396)1.94888560
86Spinal cord lesions (HP:0100561)1.94888560
87Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94749208
88Abnormality of polysaccharide metabolism (HP:0011012)1.94749208
89Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94749208
90Biconcave vertebral bodies (HP:0004586)1.94602352
91Mesomelia (HP:0003027)1.94230255
92Irregular vertebral endplates (HP:0003301)1.93060041
93Severe short stature (HP:0003510)1.92502924
94Dilatation of the ascending aorta (HP:0005111)1.92333265
95Osteoarthritis (HP:0002758)1.91931259
96Right ventricular cardiomyopathy (HP:0011663)1.91811936
97Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.91678210
98Vertebral hypoplasia (HP:0008417)1.91678210
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90284221
100Abnormal protein N-linked glycosylation (HP:0012347)1.90284221
101Abnormal protein glycosylation (HP:0012346)1.90284221
102Abnormal glycosylation (HP:0012345)1.90284221
103Mitral stenosis (HP:0001718)1.90263965
104Abnormality of the odontoid process (HP:0003310)1.89666173
105Natal tooth (HP:0000695)1.89536905
106Abnormality of the calcaneus (HP:0008364)1.88972626
107Insulin-resistant diabetes mellitus (HP:0000831)1.88535586
108Abnormality of the distal phalanges of the toes (HP:0010182)1.86948334
109Disproportionate short-trunk short stature (HP:0003521)1.85108808
110Joint stiffness (HP:0001387)1.84926577
111Bladder diverticulum (HP:0000015)1.83263103
112Trismus (HP:0000211)1.83117397
113Protuberant abdomen (HP:0001538)1.82850319
114Flat acetabular roof (HP:0003180)1.82207544
115Hand muscle atrophy (HP:0009130)1.81881128
116Thin bony cortex (HP:0002753)1.80476661
117Follicular hyperkeratosis (HP:0007502)1.78920158
118Reduced antithrombin III activity (HP:0001976)1.77873030
119Neonatal short-limb short stature (HP:0008921)1.77852552
120Spastic diplegia (HP:0001264)1.77595757
121Aplastic anemia (HP:0001915)1.77083898
122Insidious onset (HP:0003587)1.76358002
123Termporal pattern (HP:0011008)1.76358002
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.75963471
125Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75640548
126Coxa valga (HP:0002673)1.74889930
127Secondary amenorrhea (HP:0000869)1.74596974
128Ovoid vertebral bodies (HP:0003300)1.72426304
129Delayed gross motor development (HP:0002194)1.70046772
130Advanced eruption of teeth (HP:0006288)1.69372923
131Abnormal vertebral ossification (HP:0100569)1.68990427
132Abnormality of the astrocytes (HP:0100707)1.68836741
133Astrocytoma (HP:0009592)1.68836741
134Osteomalacia (HP:0002749)1.68642291
135Tetraparesis (HP:0002273)1.68210735
136Hypoplasia of the thymus (HP:0000778)1.67584510
137Spinal cord compression (HP:0002176)1.66794184
138Intrahepatic cholestasis (HP:0001406)1.66455189
139Abnormality of the lumbar spine (HP:0100712)1.66453571
140Aortic regurgitation (HP:0001659)1.66375194
141Abnormal umbilical cord blood vessels (HP:0011403)1.66311038
142Single umbilical artery (HP:0001195)1.66311038
143Abnormality of the fetal cardiovascular system (HP:0010948)1.66311038
144Mild short stature (HP:0003502)1.66272015
145Metaphyseal irregularity (HP:0003025)1.66105105
146Abnormality of the vertebral endplates (HP:0005106)1.65202778
147Abdominal distention (HP:0003270)1.64690271
148Stillbirth (HP:0003826)1.64649337
149Sparse eyelashes (HP:0000653)1.64205909
150Unilateral renal agenesis (HP:0000122)1.64019758
151Alopecia of scalp (HP:0002293)1.63723540
152Upper limb amyotrophy (HP:0009129)1.62873466
153Distal upper limb amyotrophy (HP:0007149)1.62873466
154Chromsome breakage (HP:0040012)1.61986979
155Abnormal ossification of hand bones (HP:0005921)1.61635349
156Upper limb muscle weakness (HP:0003484)1.60245390
157Chromosomal breakage induced by crosslinking agents (HP:0003221)1.60105434
158Elbow flexion contracture (HP:0002987)1.58823823
159Prominent metopic ridge (HP:0005487)1.56777133
160Congenital glaucoma (HP:0001087)1.56741356
161Abnormal hand bone ossification (HP:0010660)1.55556506
162Abnormality of oral frenula (HP:0000190)1.53805918
163Ulnar bowing (HP:0003031)1.51521980
164Increased nuchal translucency (HP:0010880)1.49573617
165Renal duplication (HP:0000075)1.49212363
166Deviation of the thumb (HP:0009603)1.49065146
167Bowel diverticulosis (HP:0005222)1.48637403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK3.46882485
2FLT32.99909675
3MST1R2.60686551
4ERN12.56822783
5NEK12.50688534
6TAOK32.39546726
7EIF2AK32.27083246
8BRSK22.20643772
9TRIM282.17521273
10VRK22.05276057
11LATS12.00526382
12FRK1.97840109
13SCYL21.96661242
14PBK1.86899010
15EPHA21.85612685
16INSRR1.75476865
17FER1.66354910
18MAP3K31.62818745
19NUAK11.59365848
20TSSK61.55158146
21BCR1.52094597
22STK101.50909545
23ERBB41.50249622
24JAK31.46918929
25ICK1.46740753
26EPHA31.45437179
27PIK3CG1.41817508
28MST41.39129103
29PKN21.38360921
30MET1.38033829
31TESK11.36703067
32TGFBR11.36461843
33EIF2AK11.34641884
34STK31.33336197
35RPS6KA41.31761700
36CDC71.31306985
37TIE11.30688628
38TRIB31.30616504
39NEK91.29358784
40BUB11.29056727
41MKNK11.25178636
42DDR21.24643168
43PDGFRA1.23558800
44TGFBR21.22864033
45SIK11.22749397
46PLK21.18380146
47LMTK21.17025475
48PTK61.16564253
49SMG11.12174712
50ZAP701.11098070
51WEE11.10411737
52PLK31.09264602
53MYLK1.08745723
54LATS21.06363718
55TRPM71.04466288
56RPS6KB21.04150544
57VRK11.02941178
58LRRK21.02204098
59TEC1.02188484
60CLK10.98275465
61ACVR1B0.95514228
62ERBB30.94531756
63PDK20.94190787
64PIM20.93773610
65MAP3K120.93152447
66PAK40.91606647
67MAP3K80.91080221
68KDR0.90155252
69ATR0.89657387
70PLK40.89397084
71FGFR20.89340303
72NEK20.87488846
73CCNB10.86633425
74AKT30.86274563
75MAP3K140.86085140
76MAPK150.85494934
77ITK0.84324821
78ZAK0.83554062
79MKNK20.83203101
80PAK20.83073249
81SIK30.81732250
82EEF2K0.80575702
83MAP2K30.80398064
84AURKB0.78847432
85IRAK30.78003123
86KIT0.77539485
87BTK0.77377694
88ILK0.76123396
89NME20.75693285
90CDK120.75596432
91TAF10.74921825
92NTRK10.74502064
93PRKG20.73533017
94TESK20.72275407
95MAPKAPK30.70926231
96STK390.70538835
97FGFR40.70346736
98CHEK20.69130215
99HIPK20.68388335
100STK38L0.66997674
101SRPK10.66464420
102BCKDK0.66334121
103CDK70.65465740
104TTN0.64860835
105CDK60.63657211
106TYK20.63251712
107PTK20.62772764
108PIM10.62256444
109PRKCI0.60530458
110CHUK0.60507084
111CSNK1G10.60118251
112JAK10.60084748
113CSF1R0.56196038
114BRSK10.55818916
115IRAK40.54694797
116LIMK10.54505778
117PLK10.54370006
118CSNK1G30.53151704
119STK160.52173268
120CSNK1A1L0.51023189
121EIF2AK20.50476076
122TTK0.50082153
123ROCK20.49478663
124ATM0.48803169
125CDK80.48415300
126CDK40.46817360
127EPHB10.46543160
128IGF1R0.45592006
129FGFR10.43901735
130FGFR30.43708797
131STK40.43563991
132CHEK10.42982917
133CDK90.42981459
134MAPKAPK20.42884570
135PDGFRB0.42393308
136MELK0.38215410
137WNK30.38061159
138DAPK10.37948546

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.78570556
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.90447773
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.21764955
4One carbon pool by folate_Homo sapiens_hsa006702.32086302
5Fatty acid elongation_Homo sapiens_hsa000622.20266375
6Sulfur metabolism_Homo sapiens_hsa009202.15800785
7DNA replication_Homo sapiens_hsa030302.12049755
8* N-Glycan biosynthesis_Homo sapiens_hsa005102.06659065
9Selenocompound metabolism_Homo sapiens_hsa004502.05855561
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03359249
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.95584486
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88869392
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.82864941
14Antigen processing and presentation_Homo sapiens_hsa046121.79755623
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65814430
16Mismatch repair_Homo sapiens_hsa034301.60504299
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58320374
18Non-homologous end-joining_Homo sapiens_hsa034501.55797794
19Vitamin B6 metabolism_Homo sapiens_hsa007501.51789611
20Folate biosynthesis_Homo sapiens_hsa007901.49755058
21Carbon metabolism_Homo sapiens_hsa012001.48792519
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47021976
23Fatty acid metabolism_Homo sapiens_hsa012121.46035443
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43906567
25Other glycan degradation_Homo sapiens_hsa005111.42182879
26Propanoate metabolism_Homo sapiens_hsa006401.38107982
27RNA transport_Homo sapiens_hsa030131.37446809
28Legionellosis_Homo sapiens_hsa051341.35173784
29Pyruvate metabolism_Homo sapiens_hsa006201.33867315
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33738722
31Cell cycle_Homo sapiens_hsa041101.33303090
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33138156
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.31557866
34ECM-receptor interaction_Homo sapiens_hsa045121.30077170
35Base excision repair_Homo sapiens_hsa034101.24956581
36Proteasome_Homo sapiens_hsa030501.24603454
37Lysosome_Homo sapiens_hsa041421.24252844
38Fructose and mannose metabolism_Homo sapiens_hsa000511.21218366
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19930880
40Galactose metabolism_Homo sapiens_hsa000521.19194216
41Nucleotide excision repair_Homo sapiens_hsa034201.15257627
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.14561370
43Caffeine metabolism_Homo sapiens_hsa002321.10591061
44Spliceosome_Homo sapiens_hsa030401.08175330
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.07758576
46p53 signaling pathway_Homo sapiens_hsa041151.03458480
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99286330
48Renin-angiotensin system_Homo sapiens_hsa046140.98975318
49Pyrimidine metabolism_Homo sapiens_hsa002400.95138585
50Homologous recombination_Homo sapiens_hsa034400.94686251
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93772961
52Small cell lung cancer_Homo sapiens_hsa052220.91970642
53Protein digestion and absorption_Homo sapiens_hsa049740.91094412
54Viral carcinogenesis_Homo sapiens_hsa052030.89895806
55RNA degradation_Homo sapiens_hsa030180.86447421
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83330199
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82029674
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81135786
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.77236971
60Starch and sucrose metabolism_Homo sapiens_hsa005000.75879501
61Focal adhesion_Homo sapiens_hsa045100.75626036
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74780563
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73633837
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72417426
65Complement and coagulation cascades_Homo sapiens_hsa046100.72002616
66Bladder cancer_Homo sapiens_hsa052190.71935287
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.69992912
68Malaria_Homo sapiens_hsa051440.69743895
69Phagosome_Homo sapiens_hsa041450.69693465
70Vibrio cholerae infection_Homo sapiens_hsa051100.69311340
71Herpes simplex infection_Homo sapiens_hsa051680.69070218
72Fatty acid biosynthesis_Homo sapiens_hsa000610.68881727
73Basal transcription factors_Homo sapiens_hsa030220.68699449
74Steroid biosynthesis_Homo sapiens_hsa001000.67149529
75Type I diabetes mellitus_Homo sapiens_hsa049400.65915856
76Hippo signaling pathway_Homo sapiens_hsa043900.65226549
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61178538
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60864706
79Measles_Homo sapiens_hsa051620.60818737
80Thyroid cancer_Homo sapiens_hsa052160.59267903
81Chronic myeloid leukemia_Homo sapiens_hsa052200.59049801
82RNA polymerase_Homo sapiens_hsa030200.58929318
83Purine metabolism_Homo sapiens_hsa002300.58493696
84TGF-beta signaling pathway_Homo sapiens_hsa043500.58313842
85Prostate cancer_Homo sapiens_hsa052150.57584262
86Apoptosis_Homo sapiens_hsa042100.57475182
87Fatty acid degradation_Homo sapiens_hsa000710.57290841
88* Metabolic pathways_Homo sapiens_hsa011000.56239791
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55327242
90Leishmaniasis_Homo sapiens_hsa051400.54805841
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54592443
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54184681
93Hepatitis B_Homo sapiens_hsa051610.53994639
94Epstein-Barr virus infection_Homo sapiens_hsa051690.53257726
95MicroRNAs in cancer_Homo sapiens_hsa052060.53196485
96Adherens junction_Homo sapiens_hsa045200.52806548
97HTLV-I infection_Homo sapiens_hsa051660.52731527
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52424469
99Systemic lupus erythematosus_Homo sapiens_hsa053220.51380520
100Toxoplasmosis_Homo sapiens_hsa051450.51259269
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51002063
102mRNA surveillance pathway_Homo sapiens_hsa030150.50817987
103Glutathione metabolism_Homo sapiens_hsa004800.50657992
104Arginine biosynthesis_Homo sapiens_hsa002200.50543529
105Shigellosis_Homo sapiens_hsa051310.49947720
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49837267
107Tryptophan metabolism_Homo sapiens_hsa003800.49692955
108Butanoate metabolism_Homo sapiens_hsa006500.48966256
109Tight junction_Homo sapiens_hsa045300.48894178
110Histidine metabolism_Homo sapiens_hsa003400.48702780
111Hematopoietic cell lineage_Homo sapiens_hsa046400.48583483
112Staphylococcus aureus infection_Homo sapiens_hsa051500.48234974
113Thyroid hormone synthesis_Homo sapiens_hsa049180.47918802
114Pentose phosphate pathway_Homo sapiens_hsa000300.46972873
115Lysine degradation_Homo sapiens_hsa003100.45910932
116Peroxisome_Homo sapiens_hsa041460.45093998
117Proteoglycans in cancer_Homo sapiens_hsa052050.44272951
118Arginine and proline metabolism_Homo sapiens_hsa003300.43694273
119Vitamin digestion and absorption_Homo sapiens_hsa049770.43130159
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.42850887
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42282937
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41987753
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41522958
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38913043
125Oocyte meiosis_Homo sapiens_hsa041140.38841034
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38751035
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37877692
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37845226
129Pancreatic cancer_Homo sapiens_hsa052120.37320861
130Fanconi anemia pathway_Homo sapiens_hsa034600.35781691
131Fat digestion and absorption_Homo sapiens_hsa049750.35297992
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34605266
133Sphingolipid metabolism_Homo sapiens_hsa006000.34382412
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.32623940
135Biosynthesis of amino acids_Homo sapiens_hsa012300.32431446

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