STT3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.79666613
2nuclear pore organization (GO:0006999)5.87973449
3pore complex assembly (GO:0046931)5.14950904
4mitotic sister chromatid cohesion (GO:0007064)4.22855393
5negative regulation of DNA repair (GO:0045738)3.97145535
6embryonic process involved in female pregnancy (GO:0060136)3.89380611
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.74632447
8monoubiquitinated protein deubiquitination (GO:0035520)3.73659048
9DNA topological change (GO:0006265)3.72185227
10mitotic chromosome condensation (GO:0007076)3.60488739
11protein localization to chromosome, centromeric region (GO:0071459)3.60026196
12chromosome condensation (GO:0030261)3.57255048
13fusion of sperm to egg plasma membrane (GO:0007342)3.54260127
14binding of sperm to zona pellucida (GO:0007339)3.45363885
15sperm-egg recognition (GO:0035036)3.44988199
16heterochromatin organization (GO:0070828)3.43826800
17regulation of RNA export from nucleus (GO:0046831)3.29056642
18mitotic nuclear envelope disassembly (GO:0007077)3.24808209
19acrosome assembly (GO:0001675)3.23932897
20protein localization to kinetochore (GO:0034501)3.22658140
21gene silencing by RNA (GO:0031047)3.22596977
22COPII vesicle coating (GO:0048208)3.21323517
23formation of translation preinitiation complex (GO:0001731)3.21104641
24synaptonemal complex assembly (GO:0007130)3.19130299
25cell adhesion mediated by integrin (GO:0033627)3.16752790
26definitive hemopoiesis (GO:0060216)3.16401913
27COPI coating of Golgi vesicle (GO:0048205)3.14899359
28Golgi transport vesicle coating (GO:0048200)3.14899359
29DNA unwinding involved in DNA replication (GO:0006268)3.13190088
30regulation of sister chromatid cohesion (GO:0007063)3.11464031
31cell-cell recognition (GO:0009988)3.11381398
32membrane disassembly (GO:0030397)3.09160176
33nuclear envelope disassembly (GO:0051081)3.09160176
34ribosome assembly (GO:0042255)3.07920389
35DNA packaging (GO:0006323)3.05105172
36RNA stabilization (GO:0043489)3.04436777
37mRNA stabilization (GO:0048255)3.04436777
38positive regulation of histone deacetylation (GO:0031065)3.03041295
39synaptonemal complex organization (GO:0070193)3.02731159
40translesion synthesis (GO:0019985)2.96869428
41pinocytosis (GO:0006907)2.96782395
42glucocorticoid receptor signaling pathway (GO:0042921)2.95879518
43piRNA metabolic process (GO:0034587)2.92501406
44sister chromatid segregation (GO:0000819)2.91114926
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90911918
46positive regulation of mitotic sister chromatid separation (GO:1901970)2.90911918
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90911918
48regulation of hippo signaling (GO:0035330)2.87560135
49sperm motility (GO:0030317)2.86900102
50protein export from nucleus (GO:0006611)2.86323336
51hypotonic response (GO:0006971)2.84788361
52chromatin assembly (GO:0031497)2.82742172
53folic acid-containing compound biosynthetic process (GO:0009396)2.81871184
54regulation of nucleobase-containing compound transport (GO:0032239)2.74441889
55nuclear envelope organization (GO:0006998)2.72304257
56multicellular organism reproduction (GO:0032504)2.72230389
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70103006
58hemidesmosome assembly (GO:0031581)2.68843211
59nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.68824905
60maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68290949
61chromosome organization involved in meiosis (GO:0070192)2.68014531
62positive regulation of nuclease activity (GO:0032075)2.66899862
63protein complex localization (GO:0031503)2.66453024
64activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.65464799
65V(D)J recombination (GO:0033151)2.65281725
66regulation of transforming growth factor beta2 production (GO:0032909)2.64986185
67male meiosis (GO:0007140)2.64926553
68paraxial mesoderm development (GO:0048339)2.64134651
69cilium or flagellum-dependent cell motility (GO:0001539)2.63725365
70regulation of histone H3-K27 methylation (GO:0061085)2.62998685
71non-recombinational repair (GO:0000726)2.61743513
72double-strand break repair via nonhomologous end joining (GO:0006303)2.61743513
73low-density lipoprotein particle clearance (GO:0034383)2.60924371
74chondrocyte development (GO:0002063)2.60589908
75corticosteroid receptor signaling pathway (GO:0031958)2.60463530
76gene silencing (GO:0016458)2.58199711
77genitalia morphogenesis (GO:0035112)2.55138582
78peptidyl-lysine dimethylation (GO:0018027)2.55104446
794-hydroxyproline metabolic process (GO:0019471)2.54992412
80regulation of glucose import in response to insulin stimulus (GO:2001273)2.54843561
81apoptotic cell clearance (GO:0043277)2.54487271
82vesicle coating (GO:0006901)2.53398422
83spermatid development (GO:0007286)2.52469188
84mitotic sister chromatid segregation (GO:0000070)2.50534627
85protein localization to endosome (GO:0036010)2.49742624
86regulation of spindle organization (GO:0090224)2.49140743
87regulation of histone H3-K9 methylation (GO:0051570)2.49031316
88regulation of centriole replication (GO:0046599)2.48423252
89regulation of fatty acid beta-oxidation (GO:0031998)2.47759837
90positive regulation of chromosome segregation (GO:0051984)2.46882101
91reproduction (GO:0000003)2.46642504
92cytoplasmic mRNA processing body assembly (GO:0033962)2.46159174
93hippo signaling (GO:0035329)2.46153138
94NLS-bearing protein import into nucleus (GO:0006607)2.45496600
95cellular response to epidermal growth factor stimulus (GO:0071364)2.45297923
96regulation of translational fidelity (GO:0006450)2.43713371
97plasma membrane fusion (GO:0045026)2.42673515
98cellular protein complex localization (GO:0034629)2.41338775
99regulation of nuclease activity (GO:0032069)2.40876050
1003-UTR-mediated mRNA stabilization (GO:0070935)2.40830696
101regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.40633767
102mitotic G2 DNA damage checkpoint (GO:0007095)2.40425022
103mitotic G2/M transition checkpoint (GO:0044818)2.40158583
104positive regulation of SMAD protein import into nucleus (GO:0060391)2.39513088
105desmosome organization (GO:0002934)2.39275872
106trophectodermal cell differentiation (GO:0001829)2.37987547
107mitotic metaphase plate congression (GO:0007080)2.36847691
108protein localization to chromosome (GO:0034502)2.36140381
109pre-miRNA processing (GO:0031054)2.35041855
110endodermal cell differentiation (GO:0035987)2.34814068
111regulation of mRNA stability (GO:0043488)2.34318509
112DNA conformation change (GO:0071103)2.34172916
113membrane protein ectodomain proteolysis (GO:0006509)2.33857223
114response to epidermal growth factor (GO:0070849)2.32972283
115endoplasmic reticulum unfolded protein response (GO:0030968)2.32645888
116maternal placenta development (GO:0001893)2.32276996
117establishment of chromosome localization (GO:0051303)2.32202595
118skin morphogenesis (GO:0043589)2.32061615
119protein retention in ER lumen (GO:0006621)2.31796947
120chaperone-mediated protein complex assembly (GO:0051131)2.31671555
121negative regulation of fatty acid transport (GO:2000192)2.30581001
122DNA replication initiation (GO:0006270)2.29994894
123DNA duplex unwinding (GO:0032508)2.28001993
124negative regulation of protein localization to plasma membrane (GO:1903077)2.27871862
125positive regulation of cell cycle checkpoint (GO:1901978)2.27850158
126cell-substrate junction assembly (GO:0007044)2.27773929
127nucleus organization (GO:0006997)2.27647286
128negative regulation of cell fate specification (GO:0009996)2.27616081
129localization within membrane (GO:0051668)2.27062906
130cellular response to unfolded protein (GO:0034620)2.26976775
131NADPH regeneration (GO:0006740)2.26545544
132establishment of integrated proviral latency (GO:0075713)2.25911439
133pentose-phosphate shunt (GO:0006098)2.25833454
134proline biosynthetic process (GO:0006561)2.25772819
135DNA geometric change (GO:0032392)2.25538227
136metaphase plate congression (GO:0051310)2.25284712
137positive regulation of protein deacetylation (GO:0090312)2.25189132
138regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.25087354
139retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.23995612
140DNA replication-dependent nucleosome assembly (GO:0006335)2.23504493
141DNA replication-dependent nucleosome organization (GO:0034723)2.23504493
142bundle of His cell to Purkinje myocyte communication (GO:0086069)2.23289135
143dosage compensation (GO:0007549)2.22618076
144sulfur amino acid catabolic process (GO:0000098)2.22614723
145negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.21676125
146regulation of mitotic spindle organization (GO:0060236)2.21167624
147negative regulation of histone methylation (GO:0031061)2.21005381
148epithelial cell-cell adhesion (GO:0090136)2.20735913
149cellular hyperosmotic response (GO:0071474)2.19924727
150regulation of early endosome to late endosome transport (GO:2000641)2.18387251
151negative regulation of fibroblast apoptotic process (GO:2000270)2.18341021
152positive regulation of catenin import into nucleus (GO:0035413)2.17369076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.34852891
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.06365539
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.02492262
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.36268972
5AR_21909140_ChIP-Seq_LNCAP_Human3.21488955
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.01644006
7MYC_22102868_ChIP-Seq_BL_Human2.60607409
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57677823
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38734332
10* CLOCK_20551151_ChIP-Seq_293T_Human2.32909152
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.30810386
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21516722
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.18255510
14GATA1_22025678_ChIP-Seq_K562_Human2.17220895
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15499097
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96365163
17* E2F1_21310950_ChIP-Seq_MCF-7_Human1.86163581
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.80609543
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78771929
20KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77788790
21ZNF263_19887448_ChIP-Seq_K562_Human1.77002942
22* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71805328
23* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.70810800
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68785930
25TCF7_22412390_ChIP-Seq_EML_Mouse1.66464735
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64286678
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61089005
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53297019
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52626275
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.51274003
31ATF3_27146783_Chip-Seq_COLON_Human1.51248381
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.51169336
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50797052
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49759548
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49716840
36* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48903824
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48148871
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45039023
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44421001
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.38953877
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38784176
42VDR_21846776_ChIP-Seq_THP-1_Human1.37488826
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36666952
44* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36420774
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36149909
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34886897
47* GATA6_25053715_ChIP-Seq_YYC3_Human1.32621334
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32393638
49CHD1_26751641_Chip-Seq_LNCaP_Human1.31072618
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26492148
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26042598
52* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22728990
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20586003
54UTX_26944678_Chip-Seq_JUKART_Human1.20244204
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19708931
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.19328665
57* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19142435
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18479278
59CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17395919
60FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16725787
61* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16715567
62TFEB_21752829_ChIP-Seq_HELA_Human1.16043037
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15655392
64MYB_26560356_Chip-Seq_TH1_Human1.15442760
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14600827
66NCOR1_26117541_ChIP-Seq_K562_Human1.14524932
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14389070
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.13729072
69KDM2B_26808549_Chip-Seq_DND41_Human1.13365004
70MYB_26560356_Chip-Seq_TH2_Human1.12537065
71* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12319966
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12277840
73MAF_26560356_Chip-Seq_TH1_Human1.11942843
74* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11476889
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09631664
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.09169546
77* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09020841
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08768632
79FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08501724
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08422100
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08080170
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.07454099
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06959550
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06910501
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.06767572
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06264331
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05974977
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05974977
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05165698
90* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03890656
91BRD4_25478319_ChIP-Seq_HGPS_Human1.03681825
92* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03642031
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03450057
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03416938
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02124914
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01843869
97* GATA4_25053715_ChIP-Seq_YYC3_Human1.01410788
98ELK1_19687146_ChIP-ChIP_HELA_Human1.00923337
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00184956
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00106392
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00033682
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99861090
103* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99621169
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98391269
105KDM5A_27292631_Chip-Seq_BREAST_Human0.98035114
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96881456
107* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96834051
108PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95448214
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95427984
110* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94606731
111* RACK7_27058665_Chip-Seq_MCF-7_Human0.94422206
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94161039
113RUNX1_22412390_ChIP-Seq_EML_Mouse0.93417507
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92991013
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91157720
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90838424
117* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90780025
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90196076
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89991672
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89771836
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89421383
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.89404040
123* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88691266
124GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88200804
125TP53_22127205_ChIP-Seq_IMR90_Human0.87903846
126VDR_24763502_ChIP-Seq_THP-1_Human0.86994577
127E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85832821
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.85387469
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.85387469
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85074581
131PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84390034
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84052080
133* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79597726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.01172091
2MP0010234_abnormal_vibrissa_follicle3.18920155
3MP0010352_gastrointestinal_tract_polyps2.86049147
4MP0008438_abnormal_cutaneous_collagen2.64025127
5MP0005410_abnormal_fertilization2.63955433
6MP0002009_preneoplasia2.53029362
7MP0003300_gastrointestinal_ulcer2.34870851
8MP0006054_spinal_hemorrhage2.29857345
9MP0005076_abnormal_cell_differentiation2.16855221
10MP0003890_abnormal_embryonic-extraembry2.12512535
11MP0003941_abnormal_skin_development1.95993483
12MP0003123_paternal_imprinting1.81393839
13MP0003566_abnormal_cell_adhesion1.77739976
14MP0004264_abnormal_extraembryonic_tissu1.77294015
15MP0000537_abnormal_urethra_morphology1.67820506
16MP0005275_abnormal_skin_tensile1.64469276
17MP0009697_abnormal_copulation1.64108964
18MP0003693_abnormal_embryo_hatching1.60932165
19MP0010307_abnormal_tumor_latency1.60027669
20MP0009053_abnormal_anal_canal1.58611217
21MP0005451_abnormal_body_composition1.56763906
22MP0008057_abnormal_DNA_replication1.53120409
23MP0001730_embryonic_growth_arrest1.51578937
24MP0003111_abnormal_nucleus_morphology1.49114066
25MP0004957_abnormal_blastocyst_morpholog1.48367196
26MP0002796_impaired_skin_barrier1.47774014
27MP0003077_abnormal_cell_cycle1.42544446
28MP0004185_abnormal_adipocyte_glucose1.42318274
29MP0005409_darkened_coat_color1.40004094
30MP0005023_abnormal_wound_healing1.35828423
31MP0004197_abnormal_fetal_growth/weight/1.35604070
32MP0009384_cardiac_valve_regurgitation1.34497524
33MP0005666_abnormal_adipose_tissue1.32727915
34MP0010094_abnormal_chromosome_stability1.31756695
35MP0002877_abnormal_melanocyte_morpholog1.30030404
36MP0002166_altered_tumor_susceptibility1.29626198
37MP0003115_abnormal_respiratory_system1.28502819
38MP0004808_abnormal_hematopoietic_stem1.27554978
39MP0008932_abnormal_embryonic_tissue1.26082409
40MP0005670_abnormal_white_adipose1.25635352
41MP0002086_abnormal_extraembryonic_tissu1.25149659
42MP0003984_embryonic_growth_retardation1.25116607
43MP0002088_abnormal_embryonic_growth/wei1.25100569
44MP0005380_embryogenesis_phenotype1.24803962
45MP0001672_abnormal_embryogenesis/_devel1.24803962
46MP0001915_intracranial_hemorrhage1.23754444
47MP0005257_abnormal_intraocular_pressure1.20786178
48MP0004272_abnormal_basement_membrane1.20267412
49MP0001929_abnormal_gametogenesis1.19765929
50MP0000350_abnormal_cell_proliferation1.19059492
51MP0000733_abnormal_muscle_development1.16768339
52MP0001849_ear_inflammation1.16094014
53MP0002139_abnormal_hepatobiliary_system1.14899735
54MP0005058_abnormal_lysosome_morphology1.12872482
55MP0003191_abnormal_cellular_cholesterol1.11755165
56MP0008877_abnormal_DNA_methylation1.09793057
57MP0000428_abnormal_craniofacial_morphol1.08102438
58MP0000569_abnormal_digit_pigmentation1.08082049
59MP0005360_urolithiasis1.05227505
60MP0000490_abnormal_crypts_of1.04959348
61MP0001697_abnormal_embryo_size1.04455220
62MP0003763_abnormal_thymus_physiology1.04087822
63MP0001661_extended_life_span1.03616251
64MP0003385_abnormal_body_wall1.02620027
65MP0003252_abnormal_bile_duct1.02574248
66MP0002060_abnormal_skin_morphology1.02258686
67MP0003943_abnormal_hepatobiliary_system1.01582833
68MP0003950_abnormal_plasma_membrane1.01405990
69MP0005621_abnormal_cell_physiology1.00336354
70MP0003221_abnormal_cardiomyocyte_apopto0.99406064
71MP0008007_abnormal_cellular_replicative0.99285857
72MP0005501_abnormal_skin_physiology0.96345014
73MP0001216_abnormal_epidermal_layer0.95935646
74MP0002084_abnormal_developmental_patter0.95688819
75MP0005375_adipose_tissue_phenotype0.92585289
76MP0002006_tumorigenesis0.92512121
77MP0002896_abnormal_bone_mineralization0.92112828
78MP0001873_stomach_inflammation0.91119432
79MP0002080_prenatal_lethality0.90850461
80MP0000462_abnormal_digestive_system0.89812928
81MP0003279_aneurysm0.89588062
82MP0002085_abnormal_embryonic_tissue0.89231392
83MP0003698_abnormal_male_reproductive0.88814395
84MP0005397_hematopoietic_system_phenotyp0.88492274
85MP0001545_abnormal_hematopoietic_system0.88492274
86MP0000465_gastrointestinal_hemorrhage0.88196833
87MP0004782_abnormal_surfactant_physiolog0.87750839
88MP0002210_abnormal_sex_determination0.87661951
89MP0005623_abnormal_meninges_morphology0.86676336
90MP0009672_abnormal_birth_weight0.86453418
91MP0002697_abnormal_eye_size0.85662789
92MP0000762_abnormal_tongue_morphology0.84877803
93MP0000627_abnormal_mammary_gland0.84872515
94MP0003091_abnormal_cell_migration0.84754998
95MP0001666_abnormal_nutrient_absorption0.84676024
96MP0010678_abnormal_skin_adnexa0.84671378
97MP0009278_abnormal_bone_marrow0.84123276
98MP0009115_abnormal_fat_cell0.83264510
99MP0000858_altered_metastatic_potential0.82095899
100MP0000609_abnormal_liver_physiology0.81893006
101MP0003453_abnormal_keratinocyte_physiol0.81683698
102MP0003567_abnormal_fetal_cardiomyocyte0.81561577
103MP0003303_peritoneal_inflammation0.81431310
104MP0001145_abnormal_male_reproductive0.80808554
105MP0002925_abnormal_cardiovascular_devel0.78995375
106MP0005408_hypopigmentation0.78829319
107MP0004084_abnormal_cardiac_muscle0.77938671
108MP0002396_abnormal_hematopoietic_system0.77851995
109MP0010329_abnormal_lipoprotein_level0.77597686
110MP0002282_abnormal_trachea_morphology0.76940535
111MP0005384_cellular_phenotype0.76593341
112MP0000477_abnormal_intestine_morphology0.75879597
113MP0003942_abnormal_urinary_system0.75866820
114MP0005365_abnormal_bile_salt0.75395585
115MP0000598_abnormal_liver_morphology0.75068919
116MP0005220_abnormal_exocrine_pancreas0.73925851
117MP0000653_abnormal_sex_gland0.73889428
118MP0000767_abnormal_smooth_muscle0.73826948
119MP0000313_abnormal_cell_death0.73359349
120MP0009703_decreased_birth_body0.72407592
121MP0000432_abnormal_head_morphology0.71418495
122MP0003868_abnormal_feces_composition0.71315418
123MP0010630_abnormal_cardiac_muscle0.70928361
124MP0003935_abnormal_craniofacial_develop0.70869923
125MP0002098_abnormal_vibrissa_morphology0.70729733
126MP0001958_emphysema0.70052831
127MP0002019_abnormal_tumor_incidence0.69398807
128MP0006138_congestive_heart_failure0.67686019
129MP0004233_abnormal_muscle_weight0.67183846
130MP0004130_abnormal_muscle_cell0.66868022
131MP0005464_abnormal_platelet_physiology0.66024014
132MP0010030_abnormal_orbit_morphology0.65712517
133MP0002092_abnormal_eye_morphology0.64846301
134MP0000377_abnormal_hair_follicle0.64551963
135MP0004947_skin_inflammation0.64315343
136MP0009840_abnormal_foam_cell0.64075604
137MP0010368_abnormal_lymphatic_system0.64045884
138MP0001243_abnormal_dermal_layer0.64000907
139MP0001614_abnormal_blood_vessel0.63945251

Predicted human phenotypes

RankGene SetZ-score
1Ankyloglossia (HP:0010296)3.87277057
2Protrusio acetabuli (HP:0003179)3.42325090
3Abnormality of oral frenula (HP:0000190)3.40353605
4Aortic aneurysm (HP:0004942)3.22315445
5Flat acetabular roof (HP:0003180)3.19087510
6Short 4th metacarpal (HP:0010044)3.11506596
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.11506596
8Cerebral aneurysm (HP:0004944)2.94791913
9Male infertility (HP:0003251)2.74031412
10Aortic dissection (HP:0002647)2.70824613
11Subacute progressive viral hepatitis (HP:0006572)2.70347150
12Rectal prolapse (HP:0002035)2.70337845
13Ankle contracture (HP:0006466)2.68699363
14Abnormality of the 4th metacarpal (HP:0010012)2.61910537
15Arterial tortuosity (HP:0005116)2.48804487
16Nasal polyposis (HP:0100582)2.48157963
17Cervical subluxation (HP:0003308)2.43330412
18Osteolytic defects of the hand bones (HP:0009699)2.40857031
19Osteolytic defects of the phalanges of the hand (HP:0009771)2.40857031
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.39456249
21Hematochezia (HP:0002573)2.38500899
22Selective tooth agenesis (HP:0001592)2.37629942
23Mitral valve prolapse (HP:0001634)2.37608682
24Shallow orbits (HP:0000586)2.37069023
25Deep philtrum (HP:0002002)2.34948871
26Acute myeloid leukemia (HP:0004808)2.31010798
27Premature rupture of membranes (HP:0001788)2.30906339
28Vascular tortuosity (HP:0004948)2.29999743
29Increased density of long bones (HP:0006392)2.29679718
30Abnormality of the lumbar spine (HP:0100712)2.24211535
31Abnormality of the nasal mucosa (HP:0000433)2.21840503
32Recurrent bronchitis (HP:0002837)2.20427633
33Enlarged penis (HP:0000040)2.20353732
34Ulnar bowing (HP:0003031)2.18727650
35High pitched voice (HP:0001620)2.17495203
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16776960
37Vertebral compression fractures (HP:0002953)2.16455336
38Aneurysm (HP:0002617)2.09748837
39Bronchitis (HP:0012387)2.09272025
40Fragile skin (HP:0001030)2.09132113
41Chromsome breakage (HP:0040012)2.08617483
42Insidious onset (HP:0003587)2.08350916
43Termporal pattern (HP:0011008)2.08350916
44Genu recurvatum (HP:0002816)2.06655434
45Increased mean platelet volume (HP:0011877)2.06369054
46Relative macrocephaly (HP:0004482)2.05232720
47Deviation of the hallux (HP:0010051)2.02777600
48Increased nuchal translucency (HP:0010880)2.02657774
49Hallux valgus (HP:0001822)2.01103152
50Infertility (HP:0000789)1.97228415
51Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.97055938
52Thin bony cortex (HP:0002753)1.96481534
53Dilatation of the ascending aorta (HP:0005111)1.96136255
54Abnormal platelet volume (HP:0011876)1.95279674
55Short nail (HP:0001799)1.94905910
56Heterotopia (HP:0002282)1.94770181
57Myocardial infarction (HP:0001658)1.94755812
58Uterine leiomyosarcoma (HP:0002891)1.94179332
59Leiomyosarcoma (HP:0100243)1.94179332
60Chronic bronchitis (HP:0004469)1.92538614
61Wormian bones (HP:0002645)1.91219912
62Increased connective tissue (HP:0009025)1.91022787
6311 pairs of ribs (HP:0000878)1.90990385
64Peritonitis (HP:0002586)1.89365573
65Back pain (HP:0003418)1.88065003
66Microglossia (HP:0000171)1.87468385
67Deviation of the thumb (HP:0009603)1.86570659
68Atrophic scars (HP:0001075)1.85632909
69Hand muscle atrophy (HP:0009130)1.84637003
70Syringomyelia (HP:0003396)1.84391505
71Spinal cord lesions (HP:0100561)1.84391505
72Biliary tract neoplasm (HP:0100574)1.82378787
73Abnormality of the calcaneus (HP:0008364)1.82205711
74Degeneration of anterior horn cells (HP:0002398)1.81929031
75Abnormality of the anterior horn cell (HP:0006802)1.81929031
76Skull defect (HP:0001362)1.81518453
77Abnormal vertebral ossification (HP:0100569)1.79929912
78Vertebral arch anomaly (HP:0008438)1.79586196
79Spondylolisthesis (HP:0003302)1.79254451
80Short middle phalanx of the 5th finger (HP:0004220)1.78557506
81Long toe (HP:0010511)1.78454366
82Lymphangioma (HP:0100764)1.78088409
83Rhizomelia (HP:0008905)1.77851188
84Deep venous thrombosis (HP:0002625)1.77841085
85Ulnar deviation of the wrist (HP:0003049)1.77793856
86Sandal gap (HP:0001852)1.77702822
87Thrombocytosis (HP:0001894)1.77223615
88Camptodactyly of toe (HP:0001836)1.76319168
89Abnormality of the common coagulation pathway (HP:0010990)1.76191802
90Asymmetry of the thorax (HP:0001555)1.76137826
91Transitional cell carcinoma of the bladder (HP:0006740)1.75038015
92Esophageal varix (HP:0002040)1.74897926
93Embryonal renal neoplasm (HP:0011794)1.74830901
94Overlapping toe (HP:0001845)1.74323656
95Abnormality of the fingertips (HP:0001211)1.73931038
96Broad face (HP:0000283)1.72934711
97Acute lymphatic leukemia (HP:0006721)1.72913315
98Abnormality of the distal phalanx of the thumb (HP:0009617)1.72548555
99Micronodular cirrhosis (HP:0001413)1.71973656
100Abnormality of carpal bone ossification (HP:0006257)1.71329464
101Broad palm (HP:0001169)1.71013909
102Delayed cranial suture closure (HP:0000270)1.70963477
103Breech presentation (HP:0001623)1.70709311
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70213662
105Nephroblastoma (Wilms tumor) (HP:0002667)1.70212581
106Gastrointestinal carcinoma (HP:0002672)1.69817517
107Malignant gastrointestinal tract tumors (HP:0006749)1.69817517
108Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69745138
109Spastic diplegia (HP:0001264)1.68605006
110Recurrent sinusitis (HP:0011108)1.68601381
111Cupped ribs (HP:0000887)1.68285651
112Disproportionate tall stature (HP:0001519)1.68256383
113Viral hepatitis (HP:0006562)1.68061791
114Abnormal tarsal ossification (HP:0008369)1.67746327
115Aplasia cutis congenita (HP:0001057)1.67549632
116Abnormality of the thoracic spine (HP:0100711)1.66855797
117Abnormality of the distal phalanges of the toes (HP:0010182)1.66637161
118Thoracolumbar scoliosis (HP:0002944)1.66060716
119Upper limb amyotrophy (HP:0009129)1.65343602
120Distal upper limb amyotrophy (HP:0007149)1.65343602
121Orthostatic hypotension (HP:0001278)1.64868001
122Delayed closure of the anterior fontanelle (HP:0001476)1.64848208
123Impulsivity (HP:0100710)1.64379067
124Breast carcinoma (HP:0003002)1.63627327
125Missing ribs (HP:0000921)1.63365311
126Disinhibition (HP:0000734)1.62213835
127Flared metaphyses (HP:0003015)1.62076200
128Abnormal delivery (HP:0001787)1.61902561
129Blue sclerae (HP:0000592)1.61523998
130Bladder neoplasm (HP:0009725)1.61037798
131Bladder carcinoma (HP:0002862)1.61037798
132Tetraparesis (HP:0002273)1.60943373
133Dislocated radial head (HP:0003083)1.60939225
134Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.60504452
135Right ventricular cardiomyopathy (HP:0011663)1.60428833
136Cortical dysplasia (HP:0002539)1.59651148
137Bicuspid aortic valve (HP:0001647)1.59579688
138Abnormal foot bone ossification (HP:0010675)1.59446859
139Bladder diverticulum (HP:0000015)1.59171129
140Hepatoblastoma (HP:0002884)1.58734245
141Renal duplication (HP:0000075)1.58170319
142Absent frontal sinuses (HP:0002688)1.57606918
143Abnormality of the left ventricular outflow tract (HP:0011103)1.57362635
144Subaortic stenosis (HP:0001682)1.57362635
145Thickened calvaria (HP:0002684)1.56984968
146Proximal placement of thumb (HP:0009623)1.56022499
147Bowel diverticulosis (HP:0005222)1.55898273
148Multiple enchondromatosis (HP:0005701)1.54662287
149Tubular atrophy (HP:0000092)1.53892118
150Milia (HP:0001056)1.52826729
151Papillary thyroid carcinoma (HP:0002895)1.51886334
152Hepatocellular carcinoma (HP:0001402)1.51794985
153Recurrent otitis media (HP:0000403)1.51588929
154Short humerus (HP:0005792)1.51087968
155Renovascular hypertension (HP:0100817)1.50278485
156Abnormality of the acetabulum (HP:0003170)1.50158545
157Hypoplastic labia majora (HP:0000059)1.49934649
158IgM deficiency (HP:0002850)1.49923126
159Buphthalmos (HP:0000557)1.49697313
160Metaphyseal cupping (HP:0003021)1.49344144
161Abnormal ossification of hand bones (HP:0005921)1.48625546
162Hyperacusis (HP:0010780)1.48583176

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.98881640
2EEF2K3.27398067
3LATS13.23682618
4PKN23.16853778
5PDK42.96520904
6PDK32.96520904
7PDK22.54550077
8PBK2.43709537
9NEK22.31087400
10TESK12.30378056
11CDC72.26222894
12SMG12.22522977
13ERN12.09870564
14STK102.03909170
15CDK122.01210467
16FRK1.95988973
17PRPF4B1.92388161
18EIF2AK31.91634284
19PRKD31.86124222
20STK31.78798857
21TTN1.77369359
22MAP3K101.65503213
23EIF2AK11.64558704
24LRRK21.57962322
25RIPK11.57196152
26PTK61.55856816
27TAF11.48300251
28MKNK11.48258319
29BRD41.46678386
30MAP3K141.45087308
31PDGFRA1.44062217
32SCYL21.43210572
33ICK1.41333233
34SIK11.38181478
35CDK61.32513735
36CAMK1D1.27497166
37LATS21.26978632
38TTK1.21527412
39SRPK11.17800621
40STK241.15922995
41ACVR1B1.14381951
42MAP3K81.13239945
43ERBB41.07610923
44MAP2K31.06915775
45TGFBR11.05064471
46NEK11.04253165
47PAK21.04178256
48MTOR1.03724605
49IRAK31.03351527
50CDK41.03281387
51RPS6KB21.02456216
52STK38L1.02129459
53MELK0.99750714
54DDR20.98587533
55MAP3K130.98545261
56TSSK60.98493481
57CAMK1G0.98423275
58MKNK20.97980457
59MAP4K10.93723572
60PAK40.92389787
61PLK40.91945775
62PASK0.91889562
63TAOK30.87463312
64YES10.86808145
65MAP3K30.86563027
66KSR20.84130860
67PDGFRB0.81575809
68TYRO30.79793351
69FGFR30.79385491
70RPS6KA40.78405197
71AURKB0.76591188
72JAK30.75624941
73MST1R0.74307526
74CLK10.72453760
75CDK90.71113302
76TGFBR20.69992685
77PNCK0.68758388
78EIF2AK20.67183141
79BMX0.66497482
80WEE10.66128712
81BRSK20.65849588
82NEK90.65204613
83NME20.64344498
84MAP3K20.63137889
85CHEK10.62684245
86FLT30.61989894
87FGFR20.61270428
88DYRK1B0.60854837
89MAPKAPK30.60814654
90TRPM70.60156996
91FGFR40.60098165
92LMTK20.59942788
93CHEK20.59629832
94RPS6KB10.56973138
95PIM10.56871240
96PTK20.56105305
97GRK60.53956166
98MOS0.53684989
99PTK2B0.51740041
100PLK30.50625205
101FGFR10.49712165
102TAOK10.49124243
103JAK10.48797960
104RET0.48732584
105PLK10.48096333
106ATR0.47228674
107STK380.47019003
108FER0.45105556
109WNK10.44177647
110MET0.44050361
111NLK0.43791766
112BMPR20.43402218
113DMPK0.43040112
114TYK20.42632779
115EPHA20.41702793
116ALK0.41359323
117BRAF0.40907490
118RAF10.40644416
119ATM0.40582775
120BUB10.40537730
121MST40.40399469
122MAP2K10.39434834
123KIT0.39413578
124CSF1R0.39212645
125KSR10.38705748
126CDK70.38232038
127JAK20.38219707
128PDK10.37748136
129STK40.36917849
130CDK80.35180668
131NTRK10.34675398
132BRSK10.33935958
133MAP3K60.31327488

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.24781465
2* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.92541993
3Cell cycle_Homo sapiens_hsa041101.79627612
4Fatty acid biosynthesis_Homo sapiens_hsa000611.78548323
5Adherens junction_Homo sapiens_hsa045201.76330548
6Other glycan degradation_Homo sapiens_hsa005111.75761688
7Small cell lung cancer_Homo sapiens_hsa052221.75728477
8Selenocompound metabolism_Homo sapiens_hsa004501.70291182
9Nitrogen metabolism_Homo sapiens_hsa009101.64674249
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62693160
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53062334
12DNA replication_Homo sapiens_hsa030301.50179533
13RNA transport_Homo sapiens_hsa030131.44317626
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43220665
15One carbon pool by folate_Homo sapiens_hsa006701.42237575
16Fat digestion and absorption_Homo sapiens_hsa049751.39140072
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39113593
18PPAR signaling pathway_Homo sapiens_hsa033201.38214249
19Fatty acid degradation_Homo sapiens_hsa000711.32538316
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.32033492
21Renal cell carcinoma_Homo sapiens_hsa052111.31236424
22Chronic myeloid leukemia_Homo sapiens_hsa052201.26945414
23MicroRNAs in cancer_Homo sapiens_hsa052061.24362314
24Propanoate metabolism_Homo sapiens_hsa006401.19780373
25Lysine degradation_Homo sapiens_hsa003101.18145188
26Focal adhesion_Homo sapiens_hsa045101.17536396
27Pancreatic cancer_Homo sapiens_hsa052121.17530626
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17319926
29Pyruvate metabolism_Homo sapiens_hsa006201.16829050
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16327121
31Renin-angiotensin system_Homo sapiens_hsa046141.15272755
32mTOR signaling pathway_Homo sapiens_hsa041501.14772863
33Antigen processing and presentation_Homo sapiens_hsa046121.14320787
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13368597
35Base excision repair_Homo sapiens_hsa034101.13208610
36Biosynthesis of amino acids_Homo sapiens_hsa012301.12852637
37Pentose phosphate pathway_Homo sapiens_hsa000301.10084427
38Glycerolipid metabolism_Homo sapiens_hsa005611.09971310
39p53 signaling pathway_Homo sapiens_hsa041151.08961527
40Nucleotide excision repair_Homo sapiens_hsa034201.07730206
41Protein digestion and absorption_Homo sapiens_hsa049741.07492933
42Bladder cancer_Homo sapiens_hsa052191.07417140
43ECM-receptor interaction_Homo sapiens_hsa045121.07052616
44Proteoglycans in cancer_Homo sapiens_hsa052051.06954348
45Insulin resistance_Homo sapiens_hsa049311.06882385
46mRNA surveillance pathway_Homo sapiens_hsa030151.06597704
47* N-Glycan biosynthesis_Homo sapiens_hsa005101.02872790
48TGF-beta signaling pathway_Homo sapiens_hsa043501.02688069
49Glioma_Homo sapiens_hsa052141.01264546
50Thyroid cancer_Homo sapiens_hsa052161.00406021
51Carbon metabolism_Homo sapiens_hsa012001.00300761
52Glucagon signaling pathway_Homo sapiens_hsa049220.99222182
53AMPK signaling pathway_Homo sapiens_hsa041520.97459333
54Endometrial cancer_Homo sapiens_hsa052130.97270927
55Prostate cancer_Homo sapiens_hsa052150.97081158
56Dorso-ventral axis formation_Homo sapiens_hsa043200.96353358
57Caffeine metabolism_Homo sapiens_hsa002320.94925324
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.92960188
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.92872411
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92579866
61Inositol phosphate metabolism_Homo sapiens_hsa005620.92065219
62Viral carcinogenesis_Homo sapiens_hsa052030.91787435
63Sulfur metabolism_Homo sapiens_hsa009200.91500338
64Fatty acid metabolism_Homo sapiens_hsa012120.91239263
65Hippo signaling pathway_Homo sapiens_hsa043900.91170041
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90686346
67Toxoplasmosis_Homo sapiens_hsa051450.89498492
68Viral myocarditis_Homo sapiens_hsa054160.89188024
69Spliceosome_Homo sapiens_hsa030400.87554929
70Pathways in cancer_Homo sapiens_hsa052000.86568151
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86543202
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86517829
73ErbB signaling pathway_Homo sapiens_hsa040120.86287702
74HTLV-I infection_Homo sapiens_hsa051660.83711971
75Colorectal cancer_Homo sapiens_hsa052100.83564464
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83489165
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82541072
78Mismatch repair_Homo sapiens_hsa034300.82346075
79Prolactin signaling pathway_Homo sapiens_hsa049170.81806369
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79839214
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79457587
82B cell receptor signaling pathway_Homo sapiens_hsa046620.76281833
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76258228
84Non-small cell lung cancer_Homo sapiens_hsa052230.76152668
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75889802
86VEGF signaling pathway_Homo sapiens_hsa043700.75613857
87Oocyte meiosis_Homo sapiens_hsa041140.73568218
88Hepatitis B_Homo sapiens_hsa051610.71358594
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69901083
90Melanoma_Homo sapiens_hsa052180.69818562
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.68327239
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.67710964
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67462573
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67185316
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66879823
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66381911
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65006055
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63725219
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.62970854
100RNA degradation_Homo sapiens_hsa030180.62822995
101Legionellosis_Homo sapiens_hsa051340.62423124
102Starch and sucrose metabolism_Homo sapiens_hsa005000.62347576
103Systemic lupus erythematosus_Homo sapiens_hsa053220.61514557
104HIF-1 signaling pathway_Homo sapiens_hsa040660.61262997
105Amoebiasis_Homo sapiens_hsa051460.61217886
106Measles_Homo sapiens_hsa051620.60989563
107Hepatitis C_Homo sapiens_hsa051600.59785008
108Tight junction_Homo sapiens_hsa045300.59467734
109Thyroid hormone synthesis_Homo sapiens_hsa049180.59296896
110Shigellosis_Homo sapiens_hsa051310.58890049
111Complement and coagulation cascades_Homo sapiens_hsa046100.57480015
112Insulin signaling pathway_Homo sapiens_hsa049100.56244933
113Wnt signaling pathway_Homo sapiens_hsa043100.55632186
114Galactose metabolism_Homo sapiens_hsa000520.55015244
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54818821
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.54548674
117Fructose and mannose metabolism_Homo sapiens_hsa000510.53638302
118Basal cell carcinoma_Homo sapiens_hsa052170.53562662
119Choline metabolism in cancer_Homo sapiens_hsa052310.53262246
120Acute myeloid leukemia_Homo sapiens_hsa052210.53133425
121Prion diseases_Homo sapiens_hsa050200.52787660
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51912267
123Glutathione metabolism_Homo sapiens_hsa004800.51779693
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51350507
125Sphingolipid metabolism_Homo sapiens_hsa006000.49332736
126Apoptosis_Homo sapiens_hsa042100.49070177
127Notch signaling pathway_Homo sapiens_hsa043300.48938511
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48239082
129Influenza A_Homo sapiens_hsa051640.47567487
130Platelet activation_Homo sapiens_hsa046110.47251746
131Bile secretion_Homo sapiens_hsa049760.46907430
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46687021
133FoxO signaling pathway_Homo sapiens_hsa040680.45860583
134Herpes simplex infection_Homo sapiens_hsa051680.45566862
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44773108
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41404781

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