STUB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.00792278
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.96148648
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.95037516
4Golgi transport vesicle coating (GO:0048200)4.61766814
5COPI coating of Golgi vesicle (GO:0048205)4.61766814
6regulation of mammary gland epithelial cell proliferation (GO:0033599)4.43679776
7ribosomal small subunit assembly (GO:0000028)4.39930637
8DNA strand elongation involved in DNA replication (GO:0006271)4.31946280
9oxidative phosphorylation (GO:0006119)4.26580133
10formation of translation preinitiation complex (GO:0001731)4.26204124
11telomere maintenance via semi-conservative replication (GO:0032201)4.10948120
12DNA strand elongation (GO:0022616)4.04523345
13galactose catabolic process (GO:0019388)3.81687126
14protein retention in ER lumen (GO:0006621)3.81144694
15folic acid-containing compound biosynthetic process (GO:0009396)3.79121052
16translational elongation (GO:0006414)3.69984808
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.69436119
18viral transcription (GO:0019083)3.68176051
19maturation of SSU-rRNA (GO:0030490)3.68152995
20GDP-mannose metabolic process (GO:0019673)3.67540350
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.66542559
22DNA unwinding involved in DNA replication (GO:0006268)3.63760987
23nucleobase biosynthetic process (GO:0046112)3.63483727
24negative regulation of erythrocyte differentiation (GO:0045647)3.63291637
25NADH metabolic process (GO:0006734)3.62724435
26translational termination (GO:0006415)3.56043713
27nucleobase-containing small molecule interconversion (GO:0015949)3.52402579
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52147593
29peptidyl-arginine omega-N-methylation (GO:0035247)3.51040469
30regulation of early endosome to late endosome transport (GO:2000641)3.48687744
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48337869
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48337869
33DNA replication initiation (GO:0006270)3.48107260
34positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.47997317
35protein maturation by protein folding (GO:0022417)3.44240471
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43249280
37regulation of mitochondrial translation (GO:0070129)3.42880784
38barbed-end actin filament capping (GO:0051016)3.41070964
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.37642360
40purine nucleobase biosynthetic process (GO:0009113)3.35654104
41spliceosomal snRNP assembly (GO:0000387)3.35382285
42protein localization to endosome (GO:0036010)3.33439041
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.32926027
44pseudouridine synthesis (GO:0001522)3.29478204
45protein targeting to ER (GO:0045047)3.28941147
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27766607
47cotranslational protein targeting to membrane (GO:0006613)3.27278914
48translational initiation (GO:0006413)3.27199538
49maternal placenta development (GO:0001893)3.26803081
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26572203
51proline biosynthetic process (GO:0006561)3.26471140
52pyrimidine nucleotide catabolic process (GO:0006244)3.25294391
53negative regulation of ligase activity (GO:0051352)3.24889412
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24889412
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24838634
56IMP biosynthetic process (GO:0006188)3.24428893
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24310685
58protein insertion into membrane (GO:0051205)3.23502437
59UV protection (GO:0009650)3.22622110
60telomere maintenance via recombination (GO:0000722)3.21827758
61histone arginine methylation (GO:0034969)3.21005144
62pteridine-containing compound biosynthetic process (GO:0042559)3.20239217
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.19925442
64response to pheromone (GO:0019236)3.19683007
65cell-substrate adherens junction assembly (GO:0007045)3.18284848
66focal adhesion assembly (GO:0048041)3.18284848
67adherens junction assembly (GO:0034333)3.17170060
68proteasome assembly (GO:0043248)3.15054062
69protein localization to endoplasmic reticulum (GO:0070972)3.11528227
70establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10747856
71pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.10356797
72ribosome assembly (GO:0042255)3.09764503
73ribosome biogenesis (GO:0042254)3.08901649
74nucleoside salvage (GO:0043174)3.07023772
75nucleoside diphosphate biosynthetic process (GO:0009133)3.05121327
76regulation of protein heterodimerization activity (GO:0043497)3.05109553
772-deoxyribonucleotide biosynthetic process (GO:0009265)3.04392028
78deoxyribose phosphate biosynthetic process (GO:0046385)3.04392028
79mitotic nuclear envelope reassembly (GO:0007084)3.03424000
80nuclear envelope reassembly (GO:0031468)3.03424000
81translation (GO:0006412)3.02954745
82regulation of translational fidelity (GO:0006450)3.01890365
83endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.97787646
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97679831
85apoptotic process involved in morphogenesis (GO:0060561)2.95353032
86ATP synthesis coupled proton transport (GO:0015986)2.95150458
87energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95150458
88establishment of protein localization to mitochondrion (GO:0072655)2.94545891
89peptidyl-arginine methylation (GO:0018216)2.94243237
90peptidyl-arginine N-methylation (GO:0035246)2.94243237
91positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.93843677
92telomere maintenance via telomere lengthening (GO:0010833)2.93517184
93glucose catabolic process (GO:0006007)2.93255472
94regulation of cellular amino acid metabolic process (GO:0006521)2.92431145
95regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.90273409
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89680272
97viral life cycle (GO:0019058)2.89445923
98protein deneddylation (GO:0000338)2.88817909
99cellular protein complex disassembly (GO:0043624)2.88276913
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.88156798
101mitotic G1 DNA damage checkpoint (GO:0031571)2.88153392
102deoxyribonucleotide biosynthetic process (GO:0009263)2.87804612
103mannose metabolic process (GO:0006013)2.87498997
104nucleotide-excision repair, DNA gap filling (GO:0006297)2.86483144
105de novo protein folding (GO:0006458)2.86309872
106mitotic recombination (GO:0006312)2.86096703
107protein targeting to mitochondrion (GO:0006626)2.85318974
108pentose-phosphate shunt (GO:0006098)2.84652043
109cullin deneddylation (GO:0010388)2.84602029
110activation of MAPKKK activity (GO:0000185)2.83209173
111modulation by virus of host process (GO:0019054)2.83014908
112tRNA aminoacylation for protein translation (GO:0006418)2.82286036
113ribonucleoprotein complex biogenesis (GO:0022613)2.81876601
114tricarboxylic acid cycle (GO:0006099)2.81809871
115ribosomal small subunit biogenesis (GO:0042274)2.81631285
116modulation by symbiont of host cellular process (GO:0044068)2.81604239
117protein peptidyl-prolyl isomerization (GO:0000413)2.81203297
118positive regulation of protein dephosphorylation (GO:0035307)2.81003078
119amino acid activation (GO:0043038)2.80810814
120tRNA aminoacylation (GO:0043039)2.80810814
121IMP metabolic process (GO:0046040)2.80154554
122DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80146742
123negative regulation of cell size (GO:0045792)2.79115306
124positive regulation of ligase activity (GO:0051351)2.77969029
125creatine metabolic process (GO:0006600)2.77674333
126pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.76419595
127establishment of integrated proviral latency (GO:0075713)2.75889827
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74633611
129adenine nucleotide transport (GO:0051503)2.74595473
130monosaccharide biosynthetic process (GO:0046364)2.70642210
131gluconeogenesis (GO:0006094)2.67001462
132guanosine-containing compound biosynthetic process (GO:1901070)2.66301369
133regulation of glucose import in response to insulin stimulus (GO:2001273)2.65642720
134negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.59566604
135proline metabolic process (GO:0006560)2.59121309
136mitochondrial fusion (GO:0008053)2.56607907
137vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55755281
138NADPH regeneration (GO:0006740)2.55007936
139planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54959166
140hexose biosynthetic process (GO:0019319)2.54930597
141nucleotide salvage (GO:0043173)2.52018069
142activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.51916205
143protein targeting to plasma membrane (GO:0072661)2.51699823
144cytoskeletal anchoring at plasma membrane (GO:0007016)2.51219250
145sodium ion export (GO:0071436)2.50826172
146adenosine receptor signaling pathway (GO:0001973)2.50732086
147positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.49912415
148cell-substrate junction assembly (GO:0007044)2.48444625
149mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.46775843
150positive regulation of synapse maturation (GO:0090129)2.45839834
151positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.44325053
152regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.44325053
153modulation by virus of host morphology or physiology (GO:0019048)2.43866588
154glutamate secretion (GO:0014047)2.42869205
155UTP biosynthetic process (GO:0006228)2.41686160
156positive regulation of nuclease activity (GO:0032075)2.41634308
157tricarboxylic acid metabolic process (GO:0072350)2.39268338
158prostaglandin biosynthetic process (GO:0001516)2.38718198
159prostanoid biosynthetic process (GO:0046457)2.38718198
160pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.38287728
161lymph vessel development (GO:0001945)2.35694480
162stress fiber assembly (GO:0043149)2.35516055
163embryo implantation (GO:0007566)2.34480127
164basement membrane organization (GO:0071711)2.32787770
165spliceosomal tri-snRNP complex assembly (GO:0000244)2.32563341
166deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.32331284
167cerebellar Purkinje cell layer development (GO:0021680)2.31268907
168protein complex localization (GO:0031503)2.30482198
169regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.30349484
170semaphorin-plexin signaling pathway (GO:0071526)2.28703619
171regulation of mitochondrial membrane potential (GO:0051881)2.27572905
172regulation of necrotic cell death (GO:0010939)2.27275841
173positive regulation of protein sumoylation (GO:0033235)2.26230726
174pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.26229757
175peptidyl-proline hydroxylation (GO:0019511)2.26002324
176synaptic vesicle exocytosis (GO:0016079)2.25416849
177pinocytosis (GO:0006907)2.24825407
178glutamine family amino acid biosynthetic process (GO:0009084)2.24467083
179mammary gland epithelial cell differentiation (GO:0060644)2.24447729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.53694813
2E2F7_22180533_ChIP-Seq_HELA_Human4.18091756
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.89095000
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90483251
5* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82591669
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.76048385
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73576352
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68886532
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55920657
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55406002
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48171594
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.47960776
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42087985
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42068312
15* XRN2_22483619_ChIP-Seq_HELA_Human2.40612852
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.28085632
17RACK7_27058665_Chip-Seq_MCF-7_Human2.24759002
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20289348
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.18339462
20* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10311229
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.07388564
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04904549
23* GABP_19822575_ChIP-Seq_HepG2_Human2.03772216
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01705745
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00603934
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95383932
27MYC_22102868_ChIP-Seq_BL_Human1.92352551
28DCP1A_22483619_ChIP-Seq_HELA_Human1.88898541
29* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.88575272
30* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85069435
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81137717
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79616915
33* KDM2B_26808549_Chip-Seq_DND41_Human1.79253591
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.78195524
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77343402
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70754254
37CIITA_25753668_ChIP-Seq_RAJI_Human1.70149442
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.70118769
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.68546955
40* SA1_27219007_Chip-Seq_ERYTHROID_Human1.65966844
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64855778
42* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64638047
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63554998
44* KDM2B_26808549_Chip-Seq_K562_Human1.60037731
45* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59714156
46* TTF2_22483619_ChIP-Seq_HELA_Human1.59141879
47VDR_23849224_ChIP-Seq_CD4+_Human1.58180859
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57728392
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.55381059
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52975044
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52815830
52VDR_21846776_ChIP-Seq_THP-1_Human1.52767506
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51940924
54* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51614319
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50768259
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.50749887
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49617705
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49616631
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47507508
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47041547
61TCF7_22412390_ChIP-Seq_EML_Mouse1.46718049
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46663201
63SMC4_20622854_ChIP-Seq_HELA_Human1.46474136
64* LXR_22292898_ChIP-Seq_THP-1_Human1.46421534
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.44960503
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44820484
67FOXP3_21729870_ChIP-Seq_TREG_Human1.44413956
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43695234
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43479888
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42939379
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39905875
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39790964
73* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37761333
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37572266
75* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36985142
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36119307
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35837144
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34573771
79CREB1_26743006_Chip-Seq_LNCaP_Human1.34254362
80* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33854674
81* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32664627
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32639446
83* YY1_22570637_ChIP-Seq_MALME-3M_Human1.31882428
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.31861780
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31338123
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31302375
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31183019
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30869153
89VDR_24763502_ChIP-Seq_THP-1_Human1.30285135
90* CTCF_27219007_Chip-Seq_Bcells_Human1.30284051
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.27880610
92* FOXP1_21924763_ChIP-Seq_HESCs_Human1.25769612
93* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24361856
94* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23932205
95MAF_26560356_Chip-Seq_TH2_Human1.23926303
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22909921
97* BCOR_27268052_Chip-Seq_Bcells_Human1.22362987
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.22079940
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21994420
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.21867216
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21175925
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19189807
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18895490
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17841196
105SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17791382
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.17554042
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.17436242
108ZNF263_19887448_ChIP-Seq_K562_Human1.17404160
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17369717
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16432956
111EGR1_19374776_ChIP-ChIP_THP-1_Human1.15993499
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15788873
113P68_20966046_ChIP-Seq_HELA_Human1.15357945
114* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15323280
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14346839
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14149905
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13561794
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13529577
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13354511
120* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13270633
121* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12832550
122TFEB_21752829_ChIP-Seq_HELA_Human1.12617384
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12450100
124TP53_22127205_ChIP-Seq_IMR90_Human1.12011291
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11735408
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11461115
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11094779
128CTCF_21964334_Chip-Seq_Bcells_Human1.11023450
129* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10379115
130TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10352883
131E2F1_21310950_ChIP-Seq_MCF-7_Human1.09803129
132* BCL6_27268052_Chip-Seq_Bcells_Human1.09057312
133* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08771762
134AR_21909140_ChIP-Seq_LNCAP_Human1.08121946
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07998092
136ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06674691
137MAF_26560356_Chip-Seq_TH1_Human1.06638612
138EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06612744
139OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06220657
140CLOCK_20551151_ChIP-Seq_293T_Human1.06139490
141RARA_24833708_ChIP-Seq_LIVER_Mouse1.05844096
142KDM5A_27292631_Chip-Seq_BREAST_Human1.05768329
143ATF3_27146783_Chip-Seq_COLON_Human1.05190990
144* SA1_27219007_Chip-Seq_Bcells_Human1.03855041
145* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03644575
146WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03594229
147* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03135074
148KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02351776
149GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02071462
150NCOR1_26117541_ChIP-Seq_K562_Human1.01600795
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01319806
152SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00875520
153CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00663740
154TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98777382
155* PHF8_20622854_ChIP-Seq_HELA_Human0.97841908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.11943799
2MP0005451_abnormal_body_composition3.99611003
3MP0004957_abnormal_blastocyst_morpholog3.08737457
4MP0003123_paternal_imprinting3.05597267
5MP0003283_abnormal_digestive_organ2.92706626
6MP0000013_abnormal_adipose_tissue2.87115247
7MP0004185_abnormal_adipocyte_glucose2.75550105
8MP0000751_myopathy2.48279579
9MP0002877_abnormal_melanocyte_morpholog2.47568513
10MP0004084_abnormal_cardiac_muscle2.46361685
11MP0006054_spinal_hemorrhage2.45117868
12MP0003111_abnormal_nucleus_morphology2.44790864
13MP0010030_abnormal_orbit_morphology2.33172623
14MP0005623_abnormal_meninges_morphology2.32496702
15MP0000749_muscle_degeneration2.28806547
16MP0003077_abnormal_cell_cycle2.28460952
17MP0003122_maternal_imprinting2.27129570
18MP0004859_abnormal_synaptic_plasticity2.26038881
19MP0008260_abnormal_autophagy2.25376511
20MP0002269_muscular_atrophy2.22029417
21MP0002837_dystrophic_cardiac_calcinosis2.08803970
22MP0006036_abnormal_mitochondrial_physio2.02641363
23MP0003329_amyloid_beta_deposits1.98985341
24MP0003303_peritoneal_inflammation1.95830495
25MP0004233_abnormal_muscle_weight1.94611576
26MP0010094_abnormal_chromosome_stability1.94077393
27MP0005666_abnormal_adipose_tissue1.93966916
28MP0008007_abnormal_cellular_replicative1.91986197
29MP0008932_abnormal_embryonic_tissue1.91321706
30MP0004133_heterotaxia1.85306694
31MP0002249_abnormal_larynx_morphology1.85280903
32MP0003279_aneurysm1.83363256
33MP0003705_abnormal_hypodermis_morpholog1.83342747
34MP0000750_abnormal_muscle_regeneration1.82668687
35MP0002909_abnormal_adrenal_gland1.81115414
36MP0002234_abnormal_pharynx_morphology1.79596321
37MP0003806_abnormal_nucleotide_metabolis1.78895050
38MP0005330_cardiomyopathy1.75710189
39MP0001730_embryonic_growth_arrest1.73029056
40MP0005375_adipose_tissue_phenotype1.72568093
41MP0009278_abnormal_bone_marrow1.72275752
42MP0000747_muscle_weakness1.71193023
43MP0004215_abnormal_myocardial_fiber1.70408144
44MP0000678_abnormal_parathyroid_gland1.68187386
45MP0004145_abnormal_muscle_electrophysio1.65982174
46MP0002089_abnormal_postnatal_growth/wei1.62941269
47MP0003453_abnormal_keratinocyte_physiol1.62563958
48MP0000358_abnormal_cell_content/1.61695729
49MP0005409_darkened_coat_color1.61405649
50MP0003191_abnormal_cellular_cholesterol1.59818582
51MP0005501_abnormal_skin_physiology1.54687788
52MP0005076_abnormal_cell_differentiation1.49393506
53MP0003119_abnormal_digestive_system1.48715645
54MP0003172_abnormal_lysosome_physiology1.48141588
55MP0002796_impaired_skin_barrier1.47626704
56MP0000733_abnormal_muscle_development1.44284121
57MP0004510_myositis1.42073603
58MP0010352_gastrointestinal_tract_polyps1.41687261
59MP0002080_prenatal_lethality1.41276853
60MP0000681_abnormal_thyroid_gland1.40250521
61MP0004036_abnormal_muscle_relaxation1.36843363
62MP0002653_abnormal_ependyma_morphology1.35503729
63MP0003075_altered_response_to1.33465461
64MP0000537_abnormal_urethra_morphology1.31784491
65MP0010234_abnormal_vibrissa_follicle1.31479942
66MP0000759_abnormal_skeletal_muscle1.31173719
67MP0003646_muscle_fatigue1.30880664
68MP0005220_abnormal_exocrine_pancreas1.29257889
69MP0000858_altered_metastatic_potential1.28853228
70MP0006035_abnormal_mitochondrial_morpho1.28126665
71MP0004087_abnormal_muscle_fiber1.28055816
72MP0001697_abnormal_embryo_size1.26959321
73MP0001661_extended_life_span1.26578766
74MP0000350_abnormal_cell_proliferation1.25917436
75MP0002396_abnormal_hematopoietic_system1.23709876
76MP0001346_abnormal_lacrimal_gland1.19087166
77MP0003137_abnormal_impulse_conducting1.19085759
78MP0000003_abnormal_adipose_tissue1.17364137
79MP0004858_abnormal_nervous_system1.17182815
80MP0003879_abnormal_hair_cell1.15684131
81MP0000534_abnormal_ureter_morphology1.15558935
82MP0005670_abnormal_white_adipose1.15417246
83MP0001348_abnormal_lacrimal_gland1.14267529
84MP0008058_abnormal_DNA_repair1.13928946
85MP0003634_abnormal_glial_cell1.13470980
86MP0000343_altered_response_to1.10740860
87MP0003221_abnormal_cardiomyocyte_apopto1.10040758
88MP0008874_decreased_physiological_sensi1.08631238
89MP0004130_abnormal_muscle_cell1.03205201
90MP0008775_abnormal_heart_ventricle1.01484504
91* MP0000313_abnormal_cell_death1.00998355
92MP0002085_abnormal_embryonic_tissue1.00828727
93MP0004272_abnormal_basement_membrane0.98712811
94MP0003942_abnormal_urinary_system0.97903841
95MP0002106_abnormal_muscle_physiology0.97769806
96MP0002084_abnormal_developmental_patter0.96724516
97MP0008438_abnormal_cutaneous_collagen0.95275669
98MP0002751_abnormal_autonomic_nervous0.95245632
99MP0005257_abnormal_intraocular_pressure0.95005696
100MP0008961_abnormal_basal_metabolism0.94352836
101MP0003121_genomic_imprinting0.93693662
102MP0005380_embryogenesis_phenotype0.93576530
103MP0001672_abnormal_embryogenesis/_devel0.93576530
104MP0010630_abnormal_cardiac_muscle0.93356299
105MP0000490_abnormal_crypts_of0.93125704
106MP0003566_abnormal_cell_adhesion0.92641954
107MP0002060_abnormal_skin_morphology0.92501288
108MP0001944_abnormal_pancreas_morphology0.89678910
109MP0003984_embryonic_growth_retardation0.88474676
110MP0003786_premature_aging0.88149119
111MP0009840_abnormal_foam_cell0.87166242
112MP0009780_abnormal_chondrocyte_physiolo0.86574316
113MP0005023_abnormal_wound_healing0.86290187
114MP0001849_ear_inflammation0.85158291
115MP0002088_abnormal_embryonic_growth/wei0.85005922
116MP0003186_abnormal_redox_activity0.85003310
117MP0000462_abnormal_digestive_system0.84782203
118MP0005385_cardiovascular_system_phenoty0.84725350
119MP0001544_abnormal_cardiovascular_syste0.84725350
120MP0005423_abnormal_somatic_nervous0.83359946
121MP0005084_abnormal_gallbladder_morpholo0.81856037
122MP0002019_abnormal_tumor_incidence0.81241161
123MP0005266_abnormal_metabolism0.80751086
124MP0009333_abnormal_splenocyte_physiolog0.80253091
125MP0004808_abnormal_hematopoietic_stem0.79341934
126MP0000604_amyloidosis0.78859507
127MP0005058_abnormal_lysosome_morphology0.77852497
128MP0003567_abnormal_fetal_cardiomyocyte0.77483433
129MP0000467_abnormal_esophagus_morphology0.77192420
130MP0005166_decreased_susceptibility_to0.76600650
131MP0003091_abnormal_cell_migration0.75856378
132MP0002972_abnormal_cardiac_muscle0.75718629
133MP0006138_congestive_heart_failure0.75339338
134MP0009672_abnormal_birth_weight0.75123611
135MP0002160_abnormal_reproductive_system0.75063347
136MP0002086_abnormal_extraembryonic_tissu0.74558308
137MP0004197_abnormal_fetal_growth/weight/0.74031324
138MP0001756_abnormal_urination0.73505263
139MP0009053_abnormal_anal_canal0.73233248
140MP0009384_cardiac_valve_regurgitation0.72788178
141MP0005620_abnormal_muscle_contractility0.72479048
142MP0005369_muscle_phenotype0.72393502
143MP0003315_abnormal_perineum_morphology0.71900229
144MP0000266_abnormal_heart_morphology0.71121964
145MP0004270_analgesia0.70747375
146MP0009379_abnormal_foot_pigmentation0.69925659
147MP0001958_emphysema0.69033991
148MP0002127_abnormal_cardiovascular_syste0.67390720
149MP0005171_absent_coat_pigmentation0.66963896
150MP0005508_abnormal_skeleton_morphology0.66941617
151MP0003959_abnormal_lean_body0.66767047
152MP0000579_abnormal_nail_morphology0.65965127
153MP0010771_integument_phenotype0.63589474
154MP0009931_abnormal_skin_appearance0.63401115
155MP0005584_abnormal_enzyme/coenzyme_acti0.62455207
156MP0008569_lethality_at_weaning0.61978400
157MP0001664_abnormal_digestion0.61783653
158* MP0005621_abnormal_cell_physiology0.61615162
159MP0004947_skin_inflammation0.61462017
160MP0000762_abnormal_tongue_morphology0.60916759
161MP0000767_abnormal_smooth_muscle0.59309007
162MP0005503_abnormal_tendon_morphology0.59047739

Predicted human phenotypes

RankGene SetZ-score
1Achilles tendon contracture (HP:0001771)3.55117565
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.53397183
3Decreased activity of mitochondrial respiratory chain (HP:0008972)3.53397183
4Abnormal number of erythroid precursors (HP:0012131)3.45124413
5Abnormality of cells of the erythroid lineage (HP:0012130)3.38677166
6Protrusio acetabuli (HP:0003179)3.30118877
7Exercise-induced myalgia (HP:0003738)3.29650592
8Distal lower limb muscle weakness (HP:0009053)3.26935733
9Selective tooth agenesis (HP:0001592)3.20780512
10Centrally nucleated skeletal muscle fibers (HP:0003687)3.15417646
11Microretrognathia (HP:0000308)3.14227879
12Abnormality of the Achilles tendon (HP:0005109)3.11836369
13Myoglobinuria (HP:0002913)3.05949301
14Progressive muscle weakness (HP:0003323)3.02755660
15Hepatic necrosis (HP:0002605)2.99451731
16Hepatocellular necrosis (HP:0001404)2.97238058
17Colon cancer (HP:0003003)2.94996900
18Increased variability in muscle fiber diameter (HP:0003557)2.94783741
19Abnormality of skeletal muscle fiber size (HP:0012084)2.83151079
20Testicular atrophy (HP:0000029)2.81508178
21Broad distal phalanx of finger (HP:0009836)2.79210526
22Ragged-red muscle fibers (HP:0003200)2.77671480
23Distal lower limb amyotrophy (HP:0008944)2.77101660
24Ulnar bowing (HP:0003031)2.76684489
25Late onset (HP:0003584)2.72839250
26Aplastic anemia (HP:0001915)2.71578116
27Hypoplasia of the pons (HP:0012110)2.68802369
28Premature rupture of membranes (HP:0001788)2.68086310
29Abnormality of the anterior horn cell (HP:0006802)2.68075719
30Degeneration of anterior horn cells (HP:0002398)2.68075719
31Increased connective tissue (HP:0009025)2.65135196
32Abnormal mitochondria in muscle tissue (HP:0008316)2.63015695
33Stridor (HP:0010307)2.59804073
34Emotional lability (HP:0000712)2.58030503
35Type 1 muscle fiber predominance (HP:0003803)2.56066807
36Limb-girdle muscle atrophy (HP:0003797)2.55308894
37Angiofibromas (HP:0010615)2.54107448
38Adenoma sebaceum (HP:0009720)2.54107448
39Slender long bone (HP:0003100)2.51354314
40Bulbar palsy (HP:0001283)2.48695290
41Difficulty climbing stairs (HP:0003551)2.48200939
42Axonal loss (HP:0003447)2.46824766
43Palpitations (HP:0001962)2.44747479
44Obstructive sleep apnea (HP:0002870)2.43662288
45Oral leukoplakia (HP:0002745)2.43231624
46Ependymoma (HP:0002888)2.43220051
47Rhabdomyolysis (HP:0003201)2.42284092
48Mitochondrial inheritance (HP:0001427)2.40713546
49Spinal rigidity (HP:0003306)2.39936155
50Increased serum lactate (HP:0002151)2.37877881
51Acute necrotizing encephalopathy (HP:0006965)2.34314723
52Trismus (HP:0000211)2.31246218
53Generalized amyotrophy (HP:0003700)2.30545384
54Multiple enchondromatosis (HP:0005701)2.29736776
55Reticulocytopenia (HP:0001896)2.27819301
56Abnormality of the lower motor neuron (HP:0002366)2.27007235
57Increased CSF lactate (HP:0002490)2.25752461
58Mildly elevated creatine phosphokinase (HP:0008180)2.24381622
59Hypercortisolism (HP:0001578)2.22764166
60Vertebral compression fractures (HP:0002953)2.22749484
61Lactic acidosis (HP:0003128)2.20281845
62Foot dorsiflexor weakness (HP:0009027)2.18702258
63Ankle contracture (HP:0006466)2.17643007
64Cerebral hypomyelination (HP:0006808)2.16129239
65Muscle stiffness (HP:0003552)2.15704176
66Dysostosis multiplex (HP:0000943)2.15624550
67Bowel diverticulosis (HP:0005222)2.15597528
68Fragile skin (HP:0001030)2.15327010
69Neoplasm of the adrenal gland (HP:0100631)2.14943366
70Thin bony cortex (HP:0002753)2.14798128
71Supranuclear gaze palsy (HP:0000605)2.13739245
72Elbow flexion contracture (HP:0002987)2.13362687
73Hyperacusis (HP:0010780)2.13010237
74Cholecystitis (HP:0001082)2.12654019
75Abnormal gallbladder physiology (HP:0012438)2.12654019
76Insomnia (HP:0100785)2.12433812
77Hyporeflexia of lower limbs (HP:0002600)2.11504874
78Renal duplication (HP:0000075)2.09200626
79Gout (HP:0001997)2.08772455
80Visual hallucinations (HP:0002367)2.08682499
81Poor head control (HP:0002421)2.08241713
82Abnormality of liposaccharide metabolism (HP:0010968)2.08057167
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.08057167
84Abnormality of glycolipid metabolism (HP:0010969)2.08057167
85Hyperparathyroidism (HP:0000843)2.06405110
86Back pain (HP:0003418)2.06208594
87Myotonia (HP:0002486)2.05449265
88Atrophy/Degeneration involving motor neurons (HP:0007373)2.05015103
89Hand muscle atrophy (HP:0009130)2.02896645
90Hyperthyroidism (HP:0000836)2.02189013
91Type I transferrin isoform profile (HP:0003642)2.01782443
9211 pairs of ribs (HP:0000878)2.01633285
93Exercise intolerance (HP:0003546)2.01321998
94Lower limb amyotrophy (HP:0007210)2.01175564
95Abnormality of the pons (HP:0007361)1.98932056
96Abnormality of alanine metabolism (HP:0010916)1.97892137
97Hyperalaninemia (HP:0003348)1.97892137
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97892137
99Spinal cord compression (HP:0002176)1.97875543
100Cerebral inclusion bodies (HP:0100314)1.97527678
101Missing ribs (HP:0000921)1.97140038
102Ketoacidosis (HP:0001993)1.96757757
103Ventricular tachycardia (HP:0004756)1.96489845
104J-shaped sella turcica (HP:0002680)1.96272372
105Turricephaly (HP:0000262)1.95420972
106Truncus arteriosus (HP:0001660)1.94701880
107Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.94158748
108Muscle fiber inclusion bodies (HP:0100299)1.93914460
109Biconcave vertebral bodies (HP:0004586)1.92368793
110Abnormality of the umbilical cord (HP:0010881)1.90254070
111Abnormal neuron morphology (HP:0012757)1.89656320
112Abnormality of the motor neurons (HP:0002450)1.89656320
113Annular pancreas (HP:0001734)1.89141328
114Abnormality of the foot musculature (HP:0001436)1.89059830
115Short nail (HP:0001799)1.87654311
116* Unsteady gait (HP:0002317)1.87335058
117Nuclear cataract (HP:0100018)1.87325274
118Growth hormone excess (HP:0000845)1.86808531
119Genu recurvatum (HP:0002816)1.84344617
120Adducted thumb (HP:0001181)1.83495903
121Carpal bone hypoplasia (HP:0001498)1.83105185
122Acute encephalopathy (HP:0006846)1.82908071
123Mitral regurgitation (HP:0001653)1.82308124
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81833585
125Abnormal number of incisors (HP:0011064)1.81789893
126Neoplasm of the pancreas (HP:0002894)1.81700021
127Respiratory failure (HP:0002878)1.80891761
128Cervical subluxation (HP:0003308)1.79937164
129Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79812289
130Abnormal protein N-linked glycosylation (HP:0012347)1.79812289
131Abnormal protein glycosylation (HP:0012346)1.79812289
132Abnormal glycosylation (HP:0012345)1.79812289
133Delusions (HP:0000746)1.79760020
134Cerebral aneurysm (HP:0004944)1.79521485
135Myokymia (HP:0002411)1.79497636
136EMG: myopathic abnormalities (HP:0003458)1.78770791
137Mesangial abnormality (HP:0001966)1.78708073
138Rough bone trabeculation (HP:0100670)1.78702879
139Sudden death (HP:0001699)1.77972500
140Calcaneovalgus deformity (HP:0001848)1.77644748
141Increased muscle lipid content (HP:0009058)1.77533461
142Abnormality of polysaccharide metabolism (HP:0011012)1.76469927
143Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76469927
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76469927
145Neurofibrillary tangles (HP:0002185)1.75916873
146Abnormality of the distal phalanges of the toes (HP:0010182)1.75887772
147Hypoglycemic coma (HP:0001325)1.75796484
148Neuroendocrine neoplasm (HP:0100634)1.74941562
149Urinary glycosaminoglycan excretion (HP:0003541)1.74856178
150Mucopolysacchariduria (HP:0008155)1.74856178
151Long palpebral fissure (HP:0000637)1.74754506
152CNS demyelination (HP:0007305)1.74326722
153Pheochromocytoma (HP:0002666)1.72842046
154Scapular winging (HP:0003691)1.72554175
155Neuronal loss in central nervous system (HP:0002529)1.72440614
156Myopathic facies (HP:0002058)1.72325348
157Asymmetric septal hypertrophy (HP:0001670)1.72155878
158Atelectasis (HP:0100750)1.71969835
159Atrioventricular block (HP:0001678)1.71296867
160Bladder diverticulum (HP:0000015)1.71256308
161Hypertensive crisis (HP:0100735)1.70980415
162Nemaline bodies (HP:0003798)1.70750225
163Premature skin wrinkling (HP:0100678)1.70409421
164Polygenic inheritance (HP:0010982)1.69692212
165Round ear (HP:0100830)1.68844599
166Abnormal atrioventricular conduction (HP:0005150)1.68833886
167Large for gestational age (HP:0001520)1.68832935
168Hypercalcemia (HP:0003072)1.68753369
169Increased cerebral lipofuscin (HP:0011813)1.68211608
170Intestinal polyposis (HP:0200008)1.68178704
171Upper limb amyotrophy (HP:0009129)1.68155868
172Distal upper limb amyotrophy (HP:0007149)1.68155868
173Broad face (HP:0000283)1.66623039
174Joint stiffness (HP:0001387)1.66495112
175Severe visual impairment (HP:0001141)1.66304331
176Bowed forearm bones (HP:0003956)1.65013135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.63672727
2SCYL23.27805153
3NEK12.93537529
4IRAK32.88106298
5TRIB32.86025259
6SMG12.82948275
7TESK22.75891519
8WEE12.73289080
9BCKDK2.68241914
10MAPKAPK32.39212564
11PKN22.26755621
12PRPF4B2.25628788
13SIK12.25264044
14TESK12.15338672
15MAP3K112.07687893
16ARAF1.97511684
17KDR1.94567444
18ICK1.87507711
19RIPK11.83705423
20PAK41.77631339
21ERN11.76284493
22NME21.69505877
23EIF2AK11.62320760
24PASK1.60256684
25MAP3K101.54316966
26LIMK11.53186931
27FLT31.50825308
28DYRK31.46043184
29NEK21.43852979
30STK161.41973114
31KSR21.41871973
32EEF2K1.40559360
33LATS21.35039840
34BRAF1.34198341
35PIM21.33777035
36DAPK11.33636253
37ILK1.33530915
38VRK21.31167491
39BRSK11.30332333
40MYLK1.23649576
41CDC71.18961152
42TTN1.16161420
43ACVR1B1.15087280
44LMTK21.15080650
45CAMKK21.14826025
46MINK11.12298316
47IRAK21.11194741
48ABL21.09666310
49LRRK21.09638733
50AURKA1.09280186
51PDPK11.09258030
52CCNB11.08755225
53MAP3K131.04513230
54TSSK61.01628584
55PAK61.01319227
56MAP3K30.99881246
57RPS6KB20.99451339
58PLK10.96484642
59EIF2AK30.95658794
60TAOK10.94702937
61MAPK120.94578290
62TGFBR10.94268495
63RPS6KA40.93882681
64MAP3K90.92544800
65MAP3K120.92321423
66MAP2K30.89183064
67BRSK20.88734991
68MOS0.87187560
69TAOK20.86506987
70UHMK10.86161302
71MAP2K20.84915758
72MAP3K80.84250474
73TBK10.83978797
74RPS6KA20.83585568
75DAPK30.82146116
76CDK70.80765578
77VRK10.80695299
78RAF10.80230068
79KSR10.79287870
80CAMKK10.78968413
81PRKD20.77709558
82CDK190.75077100
83PRKD30.74958518
84PAK10.73048414
85AURKB0.71702678
86MTOR0.71283225
87MARK20.70185616
88PHKG20.69515327
89PHKG10.69515327
90CAMK2G0.68979774
91GRK60.67777303
92NME10.64939776
93WNK30.64652950
94PRKCI0.63910807
95NTRK10.62374326
96TTK0.61126623
97MAPK110.59643853
98RPS6KL10.59572010
99RPS6KC10.59572010
100PTK60.58660029
101MUSK0.58404377
102AKT20.56368976
103PDGFRA0.55237518
104CDC42BPA0.54359709
105PTK20.54089667
106EPHA20.53506769
107EPHB20.53442895
108PDK10.53325873
109MAP2K10.53290528
110MAP2K60.52387949
111MAPK150.52277744
112PRKG20.51302625
113ATR0.51040264
114CDK120.49400172
115FER0.47829311
116DMPK0.47652393
117ZAP700.46741692
118CDK140.46722128
119MAPK40.46486188
120CDK80.46185710
121PAK20.45368502
122CDK11A0.45182328
123CDK180.44998499
124CAMK2B0.43038727
125CDK150.41985889
126MAP3K10.41268096
127GRK50.40761773
128SIK20.40372364
129PLK30.39915303
130DYRK20.39309693
131DYRK1B0.37645565
132STK380.36594726
133RPS6KA60.36584290
134IRAK40.36167977
135PDK40.36000465
136PDK30.36000465
137CDK40.35994040
138FGFR40.35356362
139OBSCN0.35183027
140PRKD10.34460394
141RIPK40.33858871
142PAK30.32888531
143PINK10.32561345
144DDR20.32061403
145MAP3K50.31317277

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49868693
2Proteasome_Homo sapiens_hsa030503.66686003
3Ribosome_Homo sapiens_hsa030103.48403253
4Mismatch repair_Homo sapiens_hsa034303.41498543
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.34075697
6Base excision repair_Homo sapiens_hsa034102.81098824
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59099370
8Spliceosome_Homo sapiens_hsa030402.49886120
9Pyrimidine metabolism_Homo sapiens_hsa002402.30430782
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29053299
11Parkinsons disease_Homo sapiens_hsa050122.20907817
12RNA polymerase_Homo sapiens_hsa030202.13516511
13RNA transport_Homo sapiens_hsa030131.98977995
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.98683972
15Nucleotide excision repair_Homo sapiens_hsa034201.96842040
16Oxidative phosphorylation_Homo sapiens_hsa001901.88429669
17Vitamin B6 metabolism_Homo sapiens_hsa007501.84455075
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82489240
19Biosynthesis of amino acids_Homo sapiens_hsa012301.81740258
20Sulfur relay system_Homo sapiens_hsa041221.66016347
21Galactose metabolism_Homo sapiens_hsa000521.65686800
22Carbon metabolism_Homo sapiens_hsa012001.61880294
23Cell cycle_Homo sapiens_hsa041101.61689207
24Huntingtons disease_Homo sapiens_hsa050161.60045416
25Cardiac muscle contraction_Homo sapiens_hsa042601.54107240
26One carbon pool by folate_Homo sapiens_hsa006701.48622915
27Fructose and mannose metabolism_Homo sapiens_hsa000511.48420208
28Acute myeloid leukemia_Homo sapiens_hsa052211.47116821
29N-Glycan biosynthesis_Homo sapiens_hsa005101.46073288
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43559321
31Non-small cell lung cancer_Homo sapiens_hsa052231.43210536
32Folate biosynthesis_Homo sapiens_hsa007901.42893004
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41184865
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38209069
35Homologous recombination_Homo sapiens_hsa034401.32166003
36Phenylalanine metabolism_Homo sapiens_hsa003601.30725732
37Glioma_Homo sapiens_hsa052141.29485485
38Alzheimers disease_Homo sapiens_hsa050101.23079078
39* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20638104
40Protein export_Homo sapiens_hsa030601.18704878
41Pentose phosphate pathway_Homo sapiens_hsa000301.13715651
42Purine metabolism_Homo sapiens_hsa002301.12611136
43Oocyte meiosis_Homo sapiens_hsa041141.09146563
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.07647772
45Synaptic vesicle cycle_Homo sapiens_hsa047211.01598659
46Thyroid cancer_Homo sapiens_hsa052161.00541011
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.00440637
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00382262
49AMPK signaling pathway_Homo sapiens_hsa041520.99511063
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98852249
51Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97363569
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97061626
53RNA degradation_Homo sapiens_hsa030180.96172167
54p53 signaling pathway_Homo sapiens_hsa041150.93923615
55Long-term potentiation_Homo sapiens_hsa047200.93222583
56Pancreatic cancer_Homo sapiens_hsa052120.91543166
57Bladder cancer_Homo sapiens_hsa052190.89134333
58Vibrio cholerae infection_Homo sapiens_hsa051100.86573716
59Arginine biosynthesis_Homo sapiens_hsa002200.86171194
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84952975
61Pyruvate metabolism_Homo sapiens_hsa006200.84768700
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.84685422
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.83815044
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83601038
65ErbB signaling pathway_Homo sapiens_hsa040120.82264613
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81862259
67GnRH signaling pathway_Homo sapiens_hsa049120.81217481
68Endocytosis_Homo sapiens_hsa041440.80054787
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77687605
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77175552
71B cell receptor signaling pathway_Homo sapiens_hsa046620.76981620
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76934896
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75520327
74Estrogen signaling pathway_Homo sapiens_hsa049150.74147243
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73839076
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.73458796
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.73190099
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73153481
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72409398
80Selenocompound metabolism_Homo sapiens_hsa004500.68421990
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.67314807
82Epstein-Barr virus infection_Homo sapiens_hsa051690.65390248
83Salmonella infection_Homo sapiens_hsa051320.65076354
84Focal adhesion_Homo sapiens_hsa045100.64393737
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62455834
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61473516
87Renal cell carcinoma_Homo sapiens_hsa052110.59984389
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59915070
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59594371
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58833832
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58008781
92mRNA surveillance pathway_Homo sapiens_hsa030150.57868387
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.56732894
94Amoebiasis_Homo sapiens_hsa051460.56210336
95Melanogenesis_Homo sapiens_hsa049160.56097108
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54373934
97Alcoholism_Homo sapiens_hsa050340.51624086
98HIF-1 signaling pathway_Homo sapiens_hsa040660.49234351
99Insulin signaling pathway_Homo sapiens_hsa049100.48864183
100Shigellosis_Homo sapiens_hsa051310.47591960
101Tyrosine metabolism_Homo sapiens_hsa003500.47247698
102Insulin secretion_Homo sapiens_hsa049110.45477452
103Renin-angiotensin system_Homo sapiens_hsa046140.45458325
104Proteoglycans in cancer_Homo sapiens_hsa052050.44719642
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42672016
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42318800
107* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42183249
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41810467
109Dilated cardiomyopathy_Homo sapiens_hsa054140.41322663
110Oxytocin signaling pathway_Homo sapiens_hsa049210.41190171
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.41030672
112Gastric acid secretion_Homo sapiens_hsa049710.40933376
113Choline metabolism in cancer_Homo sapiens_hsa052310.40752494
114Gap junction_Homo sapiens_hsa045400.40752106
115Fatty acid elongation_Homo sapiens_hsa000620.40743881
116Glucagon signaling pathway_Homo sapiens_hsa049220.39077140
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38995999
118Metabolic pathways_Homo sapiens_hsa011000.38481108
119Viral carcinogenesis_Homo sapiens_hsa052030.36817298
120HTLV-I infection_Homo sapiens_hsa051660.36641603
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34840283
122Colorectal cancer_Homo sapiens_hsa052100.34818329
123Arginine and proline metabolism_Homo sapiens_hsa003300.34574950
124Fanconi anemia pathway_Homo sapiens_hsa034600.32906209
125Glutathione metabolism_Homo sapiens_hsa004800.32889365
126Other glycan degradation_Homo sapiens_hsa005110.32517953
127VEGF signaling pathway_Homo sapiens_hsa043700.32405838
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32145953
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27395392
130Notch signaling pathway_Homo sapiens_hsa043300.26441698
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25592714
132Propanoate metabolism_Homo sapiens_hsa006400.24849607
133Prion diseases_Homo sapiens_hsa050200.24786868
134Apoptosis_Homo sapiens_hsa042100.24724376
135Hippo signaling pathway_Homo sapiens_hsa043900.22977871
136mTOR signaling pathway_Homo sapiens_hsa041500.21934351
137Lysosome_Homo sapiens_hsa041420.21803333
138Chronic myeloid leukemia_Homo sapiens_hsa052200.19857934
139Hedgehog signaling pathway_Homo sapiens_hsa043400.19664895
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18814471
141Fatty acid degradation_Homo sapiens_hsa000710.17738363
142Endometrial cancer_Homo sapiens_hsa052130.16690788
143Systemic lupus erythematosus_Homo sapiens_hsa053220.16326356
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16305990

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