ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.87219347
2	synaptic vesicle maturation (GO:0016188)	5.25923554
3	positive regulation of myoblast differentiation (GO:0045663)	5.22865858
4	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.50568815
5	glutamate secretion (GO:0014047)	4.41748945
6	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.31396977
7	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.14848421
8	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.11670931
9	locomotory exploration behavior (GO:0035641)	4.09768936
10	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	4.05588623
11	negative regulation of myoblast differentiation (GO:0045662)	4.03232586
12	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.99726865
13	regulation of synaptic vesicle exocytosis (GO:2000300)	3.97344173
14	cardiac chamber formation (GO:0003207)	3.96407843
15	venous blood vessel morphogenesis (GO:0048845)	3.93352898
16	endothelial cell chemotaxis (GO:0035767)	3.83536650
17	synaptic vesicle exocytosis (GO:0016079)	3.78067162
18	L-amino acid import (GO:0043092)	3.76445761
19	cellular potassium ion homeostasis (GO:0030007)	3.72758007
20	sodium ion export (GO:0071436)	3.71671634
21	regulation of neuronal synaptic plasticity (GO:0048168)	3.69706581
22	regulation of glutamate receptor signaling pathway (GO:1900449)	3.66014890
23	endocardial cushion morphogenesis (GO:0003203)	3.58726760
24	cell communication by electrical coupling (GO:0010644)	3.53937653
25	exploration behavior (GO:0035640)	3.52473418
26	positive regulation of synapse maturation (GO:0090129)	3.52093947
27	cerebellar granule cell differentiation (GO:0021707)	3.51973891
28	cerebellar Purkinje cell differentiation (GO:0021702)	3.51686288
29	amino acid import (GO:0043090)	3.49974769
30	positive regulation of dendritic spine development (GO:0060999)	3.44089519
31	regulation of synapse structural plasticity (GO:0051823)	3.40020597
32	response to gravity (GO:0009629)	3.34722286
33	regulation of synaptic vesicle transport (GO:1902803)	3.33531557
34	vocalization behavior (GO:0071625)	3.30858007
35	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	3.29271531
36	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.27301545
37	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.27244069
38	layer formation in cerebral cortex (GO:0021819)	3.25916948
39	dendritic spine morphogenesis (GO:0060997)	3.21706338
40	neurotransmitter-gated ion channel clustering (GO:0072578)	3.21039738
41	regulation of ARF protein signal transduction (GO:0032012)	3.19070925
42	protein localization to synapse (GO:0035418)	3.18140778
43	postsynaptic membrane organization (GO:0001941)	3.16696010
44	heart valve formation (GO:0003188)	3.14281335
45	mesenchyme morphogenesis (GO:0072132)	3.13200633
46	positive regulation of dendrite development (GO:1900006)	3.13187707
47	neurotransmitter secretion (GO:0007269)	3.12512385
48	neuromuscular process controlling balance (GO:0050885)	3.11153094
49	neuronal ion channel clustering (GO:0045161)	3.08847464
50	regulation of voltage-gated calcium channel activity (GO:1901385)	3.07251245
51	negative regulation of dendrite morphogenesis (GO:0050774)	3.04097983
52	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.01189625
53	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.00439727
54	regulation of synaptic plasticity (GO:0048167)	2.97159436
55	outflow tract septum morphogenesis (GO:0003148)	2.96022883
56	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.94600227
57	regulation of synapse maturation (GO:0090128)	2.93544371
58	neuronal action potential propagation (GO:0019227)	2.90032813
59	synaptic vesicle endocytosis (GO:0048488)	2.85495232
60	activation of protein kinase A activity (GO:0034199)	2.85412173
61	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.83944680
62	regulation of dendrite morphogenesis (GO:0048814)	2.82571976
63	regulation of dendritic spine development (GO:0060998)	2.81391747
64	negative regulation of catenin import into nucleus (GO:0035414)	2.79418806
65	long-term memory (GO:0007616)	2.78688567
66	cell communication involved in cardiac conduction (GO:0086065)	2.76915559
67	dendritic spine organization (GO:0097061)	2.76846863
68	positive regulation of membrane potential (GO:0045838)	2.73992885
69	synaptic transmission, glutamatergic (GO:0035249)	2.70130166
70	regulation of glucocorticoid metabolic process (GO:0031943)	2.67084871
71	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.63944664
72	regulation of dendrite development (GO:0050773)	2.63775897
73	cell differentiation in hindbrain (GO:0021533)	2.62420978
74	cell migration in hindbrain (GO:0021535)	2.61606695
75	regulation of dendritic spine morphogenesis (GO:0061001)	2.55815256
76	regulation of myoblast differentiation (GO:0045661)	2.55632931
77	regulation of neurotransmitter secretion (GO:0046928)	2.55543076
78	cardiac muscle cell proliferation (GO:0060038)	2.52992605
79	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.52511907
80	semaphorin-plexin signaling pathway (GO:0071526)	2.51491523
81	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.48358618
82	negative regulation of myotube differentiation (GO:0010832)	2.47793343
83	cardiac ventricle formation (GO:0003211)	2.45684588
84	regulation of postsynaptic membrane potential (GO:0060078)	2.44556762
85	negative regulation of skeletal muscle tissue development (GO:0048642)	2.40914916
86	potassium ion import (GO:0010107)	2.40131357
87	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	2.40096853
88	potassium ion homeostasis (GO:0055075)	2.40011941
89	neuromuscular synaptic transmission (GO:0007274)	2.39902114
90	astrocyte development (GO:0014002)	2.38113325
91	regulation of neurotransmitter transport (GO:0051588)	2.37889242
92	membrane depolarization during action potential (GO:0086010)	2.37227251
93	neurotransmitter transport (GO:0006836)	2.37154534
94	embryonic camera-type eye morphogenesis (GO:0048596)	2.37013104
95	axonal fasciculation (GO:0007413)	2.36640443
96	auditory behavior (GO:0031223)	2.36215985
97	neuron projection regeneration (GO:0031102)	2.34549444
98	positive regulation of neurotransmitter secretion (GO:0001956)	2.34019845
99	regulation of glomerular filtration (GO:0003093)	2.33193733
100	atrial septum morphogenesis (GO:0060413)	2.33178819

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.92856573
2	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.23313548
3	EZH2_27304074_Chip-Seq_ESCs_Mouse	3.20757854
4	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.97210223
5	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.96465518
6	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.96465518
7	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.91247247
8	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.90888190
9	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.77491443
10	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.63502804
11	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.60554958
12	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.59658294
13	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.53058358
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.47114721
15	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.45518606
16	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.41935911
17	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.34208156
18	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.33417008
19	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.29950999
20	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.29198544
21	DROSHA_22980978_ChIP-Seq_HELA_Human	2.26432497
22	KDM2B_26808549_Chip-Seq_K562_Human	2.18291166
23	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.16928535
24	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.16518395
25	LXR_22292898_ChIP-Seq_THP-1_Human	1.97147384
26	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.90129675
27	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.77699087
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.74665386
29	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.73131200
30	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.73104813
31	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.72903261
32	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.70736074
33	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.68534274
34	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.64791761
35	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.63111381
36	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.61882341
37	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.58632491
38	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.56778578
39	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.56128381
40	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.54228314
41	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.51809035
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50077429
43	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.49991027
44	KDM2B_26808549_Chip-Seq_DND41_Human	1.47613585
45	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.47161482
46	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.45141559
47	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.34818925
48	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.33947193
49	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.33435192
50	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.33387333
51	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.32771414
52	AR_21572438_ChIP-Seq_LNCaP_Human	1.31050293
53	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.28335023
54	CTCF_27219007_Chip-Seq_Bcells_Human	1.26015082
55	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.25175525
56	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.23355479
57	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.22508606
58	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.21872241
59	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.20313259
60	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.19084507
61	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.16532875
62	TCF7_22412390_ChIP-Seq_EML_Mouse	1.15983763
63	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.13066528
64	RACK7_27058665_Chip-Seq_MCF-7_Human	1.12963892
65	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.12567195
66	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.11415449
67	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.10191415
68	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.09577774
69	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.08191160
70	GBX2_23144817_ChIP-Seq_PC3_Human	1.07842338
71	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.07376635
72	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.06307024
73	CREB1_26743006_Chip-Seq_LNCaP_Human	1.04809835
74	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.01226102
75	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.99138131
76	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.98453427
77	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.97850691
78	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97789424
79	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.96559138
80	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.94031733
81	SMC4_20622854_ChIP-Seq_HELA_Human	0.92896318
82	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.91714705
83	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.91389686
84	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.91141167
85	AR_19668381_ChIP-Seq_PC3_Human	0.90752864
86	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.90663916
87	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.89962582
88	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.89883560
89	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.89191290
90	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.89191290
91	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.88254548
92	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.87826615
93	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.86707678
94	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.85864754
95	P68_20966046_ChIP-Seq_HELA_Human	0.84967199
96	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.82304345
97	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.82223524
98	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.81063244
99	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.80076417
100	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.79652146

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	6.17361963
2	MP0005423_abnormal_somatic_nervous	3.89197191
3	MP0004270_analgesia	3.66132714
4	MP0003635_abnormal_synaptic_transmissio	3.16236871
5	MP0003880_abnormal_central_pattern	2.98439429
6	MP0003705_abnormal_hypodermis_morpholog	2.83651629
7	MP0002064_seizures	2.78230890
8	MP0002063_abnormal_learning/memory/cond	2.62218818
9	MP0001486_abnormal_startle_reflex	2.45570097
10	MP0005623_abnormal_meninges_morphology	2.41348858
11	MP0003329_amyloid_beta_deposits	2.28067054
12	MP0009745_abnormal_behavioral_response	2.24967427
13	MP0001502_abnormal_circadian_rhythm	2.23771142
14	MP0002272_abnormal_nervous_system	2.05503382
15	MP0002735_abnormal_chemical_nociception	2.02622714
16	MP0002734_abnormal_mechanical_nocicepti	1.99454200
17	MP0002572_abnormal_emotion/affect_behav	1.89677628
18	MP0002249_abnormal_larynx_morphology	1.88284479
19	MP0008569_lethality_at_weaning	1.81862912
20	MP0003690_abnormal_glial_cell	1.79532989
21	MP0005409_darkened_coat_color	1.78287188
22	MP0009046_muscle_twitch	1.76371949
23	MP0003879_abnormal_hair_cell	1.72563133
24	MP0005167_abnormal_blood-brain_barrier	1.71699990
25	MP0009780_abnormal_chondrocyte_physiolo	1.69581162
26	MP0004510_myositis	1.69572091
27	MP0000751_myopathy	1.68049375
28	MP0001346_abnormal_lacrimal_gland	1.66441292
29	MP0004858_abnormal_nervous_system	1.64332054
30	MP0001968_abnormal_touch/_nociception	1.60039966
31	MP0003633_abnormal_nervous_system	1.56626271
32	MP0002089_abnormal_postnatal_growth/wei	1.52609525
33	MP0000733_abnormal_muscle_development	1.51437175
34	MP0005646_abnormal_pituitary_gland	1.49879727
35	MP0004145_abnormal_muscle_electrophysio	1.49368334
36	MP0001440_abnormal_grooming_behavior	1.47475059
37	MP0000778_abnormal_nervous_system	1.41836248
38	MP0000747_muscle_weakness	1.39792673
39	MP0001501_abnormal_sleep_pattern	1.37854341
40	MP0001970_abnormal_pain_threshold	1.36711633
41	MP0003045_fibrosis	1.36535441
42	MP0002733_abnormal_thermal_nociception	1.32392061
43	MP0004130_abnormal_muscle_cell	1.31317985
44	MP0004811_abnormal_neuron_physiology	1.27051891
45	MP0001177_atelectasis	1.26071610
46	MP0000759_abnormal_skeletal_muscle	1.25305951
47	MP0000604_amyloidosis	1.24182492
48	MP0001879_abnormal_lymphatic_vessel	1.22804550
49	MP0003283_abnormal_digestive_organ	1.22514561
50	MP0003631_nervous_system_phenotype	1.21663374
51	MP0003634_abnormal_glial_cell	1.20746233
52	MP0004036_abnormal_muscle_relaxation	1.14388144
53	MP0000749_muscle_degeneration	1.14317526
54	MP0002557_abnormal_social/conspecific_i	1.10035149
55	MP0000955_abnormal_spinal_cord	1.09028452
56	MP0000462_abnormal_digestive_system	1.08372611
57	MP0001958_emphysema	1.08352299
58	MP0008438_abnormal_cutaneous_collagen	1.07283046
59	MP0002066_abnormal_motor_capabilities/c	1.06953649
60	MP0003137_abnormal_impulse_conducting	1.06723853
61	MP0001905_abnormal_dopamine_level	1.05995693
62	MP0002882_abnormal_neuron_morphology	1.05973167
63	MP0002638_abnormal_pupillary_reflex	1.05248368
64	MP0004087_abnormal_muscle_fiber	1.04940684
65	MP0005076_abnormal_cell_differentiation	1.04265556
66	MP0003279_aneurysm	1.03275199
67	MP0003385_abnormal_body_wall	1.01214036
68	MP0002736_abnormal_nociception_after	0.99966397
69	MP0002067_abnormal_sensory_capabilities	0.99697330
70	MP0002106_abnormal_muscle_physiology	0.99156116
71	MP0000920_abnormal_myelination	0.98358026
72	MP0005620_abnormal_muscle_contractility	0.97024304
73	MP0002152_abnormal_brain_morphology	0.95986305
74	MP0010368_abnormal_lymphatic_system	0.95959561
75	MP0000534_abnormal_ureter_morphology	0.89651640
76	MP0003075_altered_response_to	0.89479783
77	MP0004924_abnormal_behavior	0.87142879
78	MP0005386_behavior/neurological_phenoty	0.87142879
79	MP0001348_abnormal_lacrimal_gland	0.82871680
80	MP0000762_abnormal_tongue_morphology	0.79117050
81	MP0005275_abnormal_skin_tensile	0.78726136
82	MP0003091_abnormal_cell_migration	0.76548623
83	MP0005369_muscle_phenotype	0.74039407
84	MP0005595_abnormal_vascular_smooth	0.73856926
85	MP0003632_abnormal_nervous_system	0.71990642
86	MP0003453_abnormal_keratinocyte_physiol	0.71967582
87	MP0010030_abnormal_orbit_morphology	0.71649354
88	MP0001270_distended_abdomen	0.69581033
89	MP0002184_abnormal_innervation	0.68386373
90	MP0003938_abnormal_ear_development	0.68161364
91	MP0010630_abnormal_cardiac_muscle	0.66049361
92	MP0002896_abnormal_bone_mineralization	0.64938528
93	MP0001915_intracranial_hemorrhage	0.64845174
94	MP0008874_decreased_physiological_sensi	0.64827332
95	MP0001984_abnormal_olfaction	0.64250415
96	MP0004133_heterotaxia	0.64187000
97	MP0002269_muscular_atrophy	0.63589601
98	MP0005670_abnormal_white_adipose	0.63416555
99	MP0001188_hyperpigmentation	0.63326163
100	MP0001943_abnormal_respiration	0.63059336

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	4.65594174
2	Obstructive sleep apnea (HP:0002870)	4.35490700
3	Focal motor seizures (HP:0011153)	3.50850220
4	Action tremor (HP:0002345)	3.47463468
5	Focal seizures (HP:0007359)	3.12380762
6	Aplasia involving bones of the upper limbs (HP:0009823)	3.11506830
7	Aplasia of the phalanges of the hand (HP:0009802)	3.11506830
8	Aplasia involving bones of the extremities (HP:0009825)	3.11506830
9	Febrile seizures (HP:0002373)	3.01949302
10	Nuclear cataract (HP:0100018)	2.93835953
11	Epileptic encephalopathy (HP:0200134)	2.87786374
12	Supranuclear gaze palsy (HP:0000605)	2.87122276
13	Hyperacusis (HP:0010780)	2.86677616
14	Turricephaly (HP:0000262)	2.77867664
15	Ankle clonus (HP:0011448)	2.77658619
16	Congenital malformation of the right heart (HP:0011723)	2.73353648
17	Double outlet right ventricle (HP:0001719)	2.73353648
18	Shallow orbits (HP:0000586)	2.70489075
19	Diplopia (HP:0000651)	2.66482454
20	Abnormality of binocular vision (HP:0011514)	2.66482454
21	Neurofibrillary tangles (HP:0002185)	2.62982790
22	Truncal ataxia (HP:0002078)	2.59792933
23	Patent foramen ovale (HP:0001655)	2.57126640
24	Cerebral aneurysm (HP:0004944)	2.56888746
25	Mask-like facies (HP:0000298)	2.53301720
26	Increased variability in muscle fiber diameter (HP:0003557)	2.51769229
27	Hyporeflexia of lower limbs (HP:0002600)	2.40519253
28	Annular pancreas (HP:0001734)	2.39792052
29	Urinary bladder sphincter dysfunction (HP:0002839)	2.36291154
30	Insomnia (HP:0100785)	2.34735695
31	Preauricular pit (HP:0004467)	2.31563577
32	Periauricular skin pits (HP:0100277)	2.31563577
33	Transposition of the great arteries (HP:0001669)	2.30667810
34	Abnormal connection of the cardiac segments (HP:0011545)	2.30667810
35	Abnormal ventriculo-arterial connection (HP:0011563)	2.30667810
36	Neoplasm of the heart (HP:0100544)	2.25002825
37	Poor eye contact (HP:0000817)	2.23995999
38	Difficulty running (HP:0009046)	2.23609218
39	Atonic seizures (HP:0010819)	2.23077740
40	Exercise-induced myalgia (HP:0003738)	2.17346337
41	Cerebral inclusion bodies (HP:0100314)	2.16398623
42	Lower limb amyotrophy (HP:0007210)	2.16157312
43	Spastic gait (HP:0002064)	2.15868795
44	Dysmetria (HP:0001310)	2.15251624
45	Megalencephaly (HP:0001355)	2.14808360
46	Anomalous pulmonary venous return (HP:0010772)	2.14645311
47	Skin pits (HP:0100276)	2.11568578
48	Round ear (HP:0100830)	2.08086398
49	Lymphangioma (HP:0100764)	2.07080207
50	Renovascular hypertension (HP:0100817)	2.03223666
51	Progressive cerebellar ataxia (HP:0002073)	2.02434525
52	Hemiplegia (HP:0002301)	2.01730862
53	Hypoplasia of the iris (HP:0007676)	2.01559610
54	Truncus arteriosus (HP:0001660)	2.00790449
55	Pointed chin (HP:0000307)	1.99047860
56	Abnormality of the 4th metacarpal (HP:0010012)	1.99007188
57	Abnormality of skeletal muscle fiber size (HP:0012084)	1.97749336
58	Visual hallucinations (HP:0002367)	1.95426307
59	Mitral valve prolapse (HP:0001634)	1.95182477
60	Sudden death (HP:0001699)	1.94337470
61	Bladder diverticulum (HP:0000015)	1.93470123
62	Overgrowth (HP:0001548)	1.91989636
63	Impaired social interactions (HP:0000735)	1.91038871
64	Abnormal social behavior (HP:0012433)	1.91038871
65	Hyperkalemia (HP:0002153)	1.90666841
66	Depression (HP:0000716)	1.89826261
67	Short 4th metacarpal (HP:0010044)	1.89663279
68	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.89663279
69	Sleep apnea (HP:0010535)	1.88285932
70	Bronchomalacia (HP:0002780)	1.87894146
71	Stereotypic behavior (HP:0000733)	1.86368826
72	Scanning speech (HP:0002168)	1.86108712
73	Overriding aorta (HP:0002623)	1.85667965
74	Akinesia (HP:0002304)	1.85084480
75	Abnormality of the pulmonary veins (HP:0011718)	1.84089989
76	Infantile muscular hypotonia (HP:0008947)	1.83968693
77	Cutaneous finger syndactyly (HP:0010554)	1.83277838
78	Prolonged QT interval (HP:0001657)	1.82971240
79	Postural instability (HP:0002172)	1.82700714
80	Syncope (HP:0001279)	1.82616762
81	Germ cell neoplasia (HP:0100728)	1.79440570
82	Lower limb asymmetry (HP:0100559)	1.79076019
83	Neonatal short-limb short stature (HP:0008921)	1.78435936
84	Fragile skin (HP:0001030)	1.77094581
85	Elfin facies (HP:0004428)	1.75850492
86	Broad distal phalanx of finger (HP:0009836)	1.75257549
87	Cutaneous syndactyly (HP:0012725)	1.72898938
88	Neuronal loss in central nervous system (HP:0002529)	1.70901890
89	Broad face (HP:0000283)	1.70351104
90	Ulnar bowing (HP:0003031)	1.69873449
91	Heart block (HP:0012722)	1.69516797
92	Myotonia (HP:0002486)	1.68578452
93	Renal duplication (HP:0000075)	1.67597082
94	Arterial tortuosity (HP:0005116)	1.66362605
95	Amblyopia (HP:0000646)	1.66128624
96	Generalized tonic-clonic seizures (HP:0002069)	1.65520013
97	Abnormal atrioventricular conduction (HP:0005150)	1.65296605
98	Bundle branch block (HP:0011710)	1.65064914
99	Abnormality of the fingertips (HP:0001211)	1.64431679
100	Complete atrioventricular canal defect (HP:0001674)	1.63638380

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	4.73137016
2	PRKD3	3.48377422
3	PKN2	3.18528081
4	NTRK3	2.98408689
5	PRPF4B	2.75330205
6	RIPK1	2.51065974
7	PAK6	2.48627901
8	DAPK2	2.37518678
9	TRIB3	2.25504883
10	MARK1	2.22992411
11	NTRK1	1.90993512
12	LATS2	1.77730178
13	NTRK2	1.70298499
14	TYRO3	1.65906613
15	MARK2	1.64989327
16	CAMKK1	1.64081284
17	MAPK12	1.61096441
18	PHKG2	1.60024091
19	PHKG1	1.60024091
20	TTN	1.34768041
21	CDK12	1.34171572
22	ARAF	1.31685326
23	UHMK1	1.26700510
24	SGK3	1.24464255
25	SGK223	1.23814464
26	SGK494	1.23814464
27	SGK2	1.21888553
28	PRKCH	1.20207321
29	STK38	1.18169575
30	CDK5	1.11176428
31	CAMK2B	1.10659998
32	ICK	1.10152275
33	MAP3K9	1.09238326
34	RET	1.08465966
35	NEK6	1.07472683
36	MINK1	1.05170411
37	CAMK1D	1.05076717
38	CAMK1	1.02876656
39	PDGFRA	1.01576365
40	TIE1	0.99781815
41	CAMK2G	0.98818047
42	MAP3K1	0.97994190
43	FLT3	0.92622509
44	CAMK4	0.91132085
45	KSR2	0.89971552
46	OBSCN	0.85885969
47	MAP2K4	0.85628788
48	CAMK1G	0.83579654
49	IRAK2	0.83203469
50	MAPK7	0.81993370
51	PDK1	0.79802201
52	CASK	0.79240549
53	MAPKAPK3	0.78509887
54	SIK2	0.76646737
55	PRKD2	0.76041251
56	MAPK13	0.75917892
57	MAP2K7	0.75323478
58	PKN1	0.74978716
59	MTOR	0.72747308
60	DDR2	0.71282523
61	MAPK4	0.70601820
62	STK11	0.66956053
63	MAPK10	0.66756462
64	PDPK1	0.66135338
65	PTK2	0.66066494
66	FGFR2	0.65818278
67	EEF2K	0.65160084
68	MAP3K11	0.63978819
69	PINK1	0.63272885
70	GRK7	0.62582302
71	RPS6KA2	0.62311205
72	DAPK1	0.62094205
73	SGK1	0.60388539
74	TAOK2	0.59820688
75	FES	0.58589148
76	MAP3K13	0.58201400
77	CAMK2A	0.56899821
78	IRAK3	0.56521111
79	SIK1	0.55330615
80	ROCK1	0.55033338
81	FGFR3	0.53666768
82	ROCK2	0.52820691
83	GRK5	0.52694824
84	CAMK2D	0.52084623
85	MAP3K7	0.51244067
86	MAP3K6	0.50761821
87	PDGFRB	0.50338767
88	DMPK	0.49854091
89	DAPK3	0.49484769
90	HIPK2	0.48750055
91	PRKD1	0.46391193
92	ALK	0.44743316
93	BRAF	0.44644543
94	WNK1	0.44019113
95	ABL2	0.43509114
96	RPS6KA3	0.42908565
97	MAPK8	0.40963381
98	CCNB1	0.40190370
99	RIPK4	0.39983989
100	RPS6KC1	0.38908333

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Long-term potentiation_Homo sapiens_hsa04720	2.44765078
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.27821325
3	Circadian entrainment_Homo sapiens_hsa04713	2.27042330
4	Nicotine addiction_Homo sapiens_hsa05033	2.17963789
5	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.99820704
6	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.98697402
7	Glutamatergic synapse_Homo sapiens_hsa04724	1.94919841
8	Gastric acid secretion_Homo sapiens_hsa04971	1.91552483
9	Amphetamine addiction_Homo sapiens_hsa05031	1.88162012
10	Insulin secretion_Homo sapiens_hsa04911	1.86847951
11	GABAergic synapse_Homo sapiens_hsa04727	1.83164096
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.79971388
13	Morphine addiction_Homo sapiens_hsa05032	1.78062091
14	Glioma_Homo sapiens_hsa05214	1.69155394
15	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.68632579
16	Cholinergic synapse_Homo sapiens_hsa04725	1.68465375
17	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.66097061
18	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.58838629
19	GnRH signaling pathway_Homo sapiens_hsa04912	1.54896820
20	Calcium signaling pathway_Homo sapiens_hsa04020	1.54748117
21	Renin secretion_Homo sapiens_hsa04924	1.54655011
22	Dopaminergic synapse_Homo sapiens_hsa04728	1.47789178
23	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.44661832
24	Salivary secretion_Homo sapiens_hsa04970	1.41835369
25	Estrogen signaling pathway_Homo sapiens_hsa04915	1.38536684
26	cAMP signaling pathway_Homo sapiens_hsa04024	1.32979375
27	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.32466240
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.31903645
29	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.31328878
30	ErbB signaling pathway_Homo sapiens_hsa04012	1.30008292
31	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.28466367
32	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.28027129
33	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.27880054
34	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.27842749
35	VEGF signaling pathway_Homo sapiens_hsa04370	1.25328725
36	Melanogenesis_Homo sapiens_hsa04916	1.23501960
37	Cocaine addiction_Homo sapiens_hsa05030	1.18254940
38	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.15562582
39	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.12474312
40	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.08053975
41	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.06815867
42	Gap junction_Homo sapiens_hsa04540	1.04826873
43	Long-term depression_Homo sapiens_hsa04730	1.04478694
44	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.02341931
45	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.01464536
46	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.00298384
47	Prion diseases_Homo sapiens_hsa05020	0.99311998
48	Axon guidance_Homo sapiens_hsa04360	0.99146296
49	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.97755279
50	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.94150547
51	Type II diabetes mellitus_Homo sapiens_hsa04930	0.93003897
52	Taste transduction_Homo sapiens_hsa04742	0.92325474
53	MAPK signaling pathway_Homo sapiens_hsa04010	0.89075620
54	Tight junction_Homo sapiens_hsa04530	0.88657951
55	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.87558746
56	Hippo signaling pathway_Homo sapiens_hsa04390	0.87227464
57	Focal adhesion_Homo sapiens_hsa04510	0.86972266
58	Non-small cell lung cancer_Homo sapiens_hsa05223	0.86809522
59	Rap1 signaling pathway_Homo sapiens_hsa04015	0.84695138
60	Notch signaling pathway_Homo sapiens_hsa04330	0.84559663
61	Endometrial cancer_Homo sapiens_hsa05213	0.80133904
62	Alcoholism_Homo sapiens_hsa05034	0.79740716
63	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.79574956
64	Choline metabolism in cancer_Homo sapiens_hsa05231	0.79261795
65	Renal cell carcinoma_Homo sapiens_hsa05211	0.77976033
66	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.77877411
67	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.75731132
68	Pancreatic secretion_Homo sapiens_hsa04972	0.75265651
69	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.73620121
70	Amoebiasis_Homo sapiens_hsa05146	0.73118948
71	mTOR signaling pathway_Homo sapiens_hsa04150	0.72914605
72	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.72895793
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.71822820
74	Insulin signaling pathway_Homo sapiens_hsa04910	0.71589106
75	ECM-receptor interaction_Homo sapiens_hsa04512	0.71325338
76	Bile secretion_Homo sapiens_hsa04976	0.69340041
77	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.69154819
78	Ras signaling pathway_Homo sapiens_hsa04014	0.66813219
79	Serotonergic synapse_Homo sapiens_hsa04726	0.66706970
80	Glucagon signaling pathway_Homo sapiens_hsa04922	0.66658112
81	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.66622188
82	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.65114884
83	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.64611099
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.64423046
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60328989
86	Endocytosis_Homo sapiens_hsa04144	0.60031375
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.58202196
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.57510553
89	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.55625783
90	Olfactory transduction_Homo sapiens_hsa04740	0.55191785
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54913537
92	AMPK signaling pathway_Homo sapiens_hsa04152	0.54776692
93	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.51474533
94	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.50629936
95	Proteoglycans in cancer_Homo sapiens_hsa05205	0.50106410
96	Circadian rhythm_Homo sapiens_hsa04710	0.48039073
97	Pancreatic cancer_Homo sapiens_hsa05212	0.46741200
98	Vibrio cholerae infection_Homo sapiens_hsa05110	0.46432765
99	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.45375815
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.45127647

STUM

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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