STX10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.04265595
2negative regulation of cell killing (GO:0031342)5.04265595
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.90613267
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.90613267
5modulation by symbiont of host immune response (GO:0052553)4.90613267
6positive regulation by symbiont of host defense response (GO:0052509)4.90613267
7modulation by symbiont of host defense response (GO:0052031)4.90613267
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.90613267
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80437033
10neutrophil activation involved in immune response (GO:0002283)4.79315467
11response to peptidoglycan (GO:0032494)4.71852586
12antigen processing and presentation of endogenous antigen (GO:0019883)4.66392184
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.62478360
14positive regulation of gamma-delta T cell activation (GO:0046645)4.52413513
15detection of other organism (GO:0098543)4.47408088
16detection of bacterium (GO:0016045)4.40114202
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21995694
18negative regulation of erythrocyte differentiation (GO:0045647)3.94075375
19leukocyte aggregation (GO:0070486)3.90638210
20regulation of mast cell degranulation (GO:0043304)3.86109595
21macrophage activation involved in immune response (GO:0002281)3.76480630
22detection of external biotic stimulus (GO:0098581)3.75169159
23immunoglobulin mediated immune response (GO:0016064)3.69440831
24regulation of interferon-beta biosynthetic process (GO:0045357)3.68916663
25respiratory burst (GO:0045730)3.66370044
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.63366646
27regulation of B cell receptor signaling pathway (GO:0050855)3.62830136
28negative regulation of interleukin-12 production (GO:0032695)3.62725340
29regulation of myeloid leukocyte mediated immunity (GO:0002886)3.61266752
30regulation of mast cell activation involved in immune response (GO:0033006)3.53678299
31regulation of leukocyte degranulation (GO:0043300)3.50775832
32neutrophil activation (GO:0042119)3.45512329
33detection of biotic stimulus (GO:0009595)3.40492406
34negative regulation of phagocytosis (GO:0050765)3.34734025
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31449797
36response to host immune response (GO:0052572)3.31449797
37cellular extravasation (GO:0045123)3.31028040
38detection of molecule of bacterial origin (GO:0032490)3.30437418
39granulocyte activation (GO:0036230)3.28956208
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.28141839
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.18628271
42response to muramyl dipeptide (GO:0032495)3.14130326
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.13251129
44positive regulation of B cell differentiation (GO:0045579)3.11622637
45positive regulation of mast cell activation (GO:0033005)3.11012191
46negative regulation of leukocyte mediated immunity (GO:0002704)3.08958170
47response to host (GO:0075136)3.08602219
48response to host defenses (GO:0052200)3.08602219
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08602219
50myeloid cell activation involved in immune response (GO:0002275)3.07436669
51positive regulation of mast cell activation involved in immune response (GO:0033008)3.05239214
52positive regulation of mast cell degranulation (GO:0043306)3.05239214
53germinal center formation (GO:0002467)3.03806396
54lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01550467
55pinocytosis (GO:0006907)3.01238051
56regulation of T cell tolerance induction (GO:0002664)3.00315124
57leukocyte migration involved in inflammatory response (GO:0002523)2.96776300
58NIK/NF-kappaB signaling (GO:0038061)2.96495084
59type I interferon signaling pathway (GO:0060337)2.95425446
60cellular response to type I interferon (GO:0071357)2.95425446
61regulation of gamma-delta T cell activation (GO:0046643)2.93151481
62antigen processing and presentation via MHC class Ib (GO:0002475)2.93051718
63regulation of superoxide anion generation (GO:0032928)2.92005614
64neutrophil mediated immunity (GO:0002446)2.91271253
65response to type I interferon (GO:0034340)2.91202898
66regulation of tolerance induction (GO:0002643)2.89180983
67regulation of mast cell activation (GO:0033003)2.89017679
68negative regulation of innate immune response (GO:0045824)2.88228215
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.84745906
70positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.81748942
71regulation of regulated secretory pathway (GO:1903305)2.78494566
72negative regulation of glycoprotein biosynthetic process (GO:0010561)2.77647381
73B cell mediated immunity (GO:0019724)2.77232397
74regulation of B cell differentiation (GO:0045577)2.75966393
75macrophage activation (GO:0042116)2.75926619
76pentose-phosphate shunt (GO:0006098)2.75130675
77B cell receptor signaling pathway (GO:0050853)2.74179771
78leukocyte degranulation (GO:0043299)2.69752123
79defense response to protozoan (GO:0042832)2.66541824
80positive thymic T cell selection (GO:0045059)2.62774224
81pyrimidine nucleoside salvage (GO:0043097)2.62581632
82pyrimidine-containing compound salvage (GO:0008655)2.62581632
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62157400
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.61778579
85microglial cell activation (GO:0001774)2.61763233
86positive regulation of leukocyte degranulation (GO:0043302)2.59892858
87modulation by virus of host process (GO:0019054)2.59764905
88negative regulation of interleukin-6 production (GO:0032715)2.59464600
89positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.58937940
90regulation of gamma-delta T cell differentiation (GO:0045586)2.58724290
91regulation of natural killer cell mediated immunity (GO:0002715)2.58238234
92regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.58238234
93barbed-end actin filament capping (GO:0051016)2.57395422
94positive regulation of Cdc42 GTPase activity (GO:0043089)2.53676612
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.52889077
96response to interleukin-15 (GO:0070672)2.51647286
97negative regulation of cytokine production involved in immune response (GO:0002719)2.49954707
98positive regulation of interferon-alpha production (GO:0032727)2.48335180
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45776903
100interferon-gamma-mediated signaling pathway (GO:0060333)2.45615059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.31558047
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.01373538
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.86270736
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.62064955
5MYC_22102868_ChIP-Seq_BL_Human2.51746598
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43884088
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33563659
8VDR_24763502_ChIP-Seq_THP-1_Human2.27656829
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24277577
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19909248
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.17671192
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17079283
13LXR_22292898_ChIP-Seq_THP-1_Human2.16799899
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.09768346
15* SPI1_23547873_ChIP-Seq_NB4_Human2.08403530
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08135583
17MAF_26560356_Chip-Seq_TH1_Human2.05623561
18RUNX1_22412390_ChIP-Seq_EML_Mouse1.93437018
19UTX_26944678_Chip-Seq_JUKART_Human1.91961492
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91585484
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91435988
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91037862
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89507418
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85428396
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84075306
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83230401
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82281406
28MAF_26560356_Chip-Seq_TH2_Human1.81224474
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74607103
30TCF7_22412390_ChIP-Seq_EML_Mouse1.71810326
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67702269
32KDM2B_26808549_Chip-Seq_DND41_Human1.65849389
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63540576
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61818315
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.60916503
36SPI1_23127762_ChIP-Seq_K562_Human1.60583580
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60352029
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56428827
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.55217105
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52772722
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51897259
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51462210
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50404189
44RACK7_27058665_Chip-Seq_MCF-7_Human1.44656399
45GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43977601
46BCL6_27268052_Chip-Seq_Bcells_Human1.42844628
47* ELF1_20517297_ChIP-Seq_JURKAT_Human1.42778219
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42543928
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41547046
50P68_20966046_ChIP-Seq_HELA_Human1.40026979
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39490164
52MYB_26560356_Chip-Seq_TH2_Human1.39034245
53BCOR_27268052_Chip-Seq_Bcells_Human1.38827785
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.38559741
55* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37873886
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36503835
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36491980
58SCL_19346495_ChIP-Seq_HPC-7_Human1.35940295
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35430830
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35027152
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32911160
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31839657
63MYB_26560356_Chip-Seq_TH1_Human1.30950322
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30164009
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29231058
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.27955922
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27648957
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27384171
69NCOR1_26117541_ChIP-Seq_K562_Human1.25196080
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24959420
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23913208
72* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23192151
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22663825
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22351216
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20804432
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19802383
77CTCF_26484167_Chip-Seq_Bcells_Mouse1.17322686
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16927713
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16721251
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.14833957
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13517198
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12560276
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07478446
84TFEB_21752829_ChIP-Seq_HELA_Human1.07312800
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.06234784
86CIITA_25753668_ChIP-Seq_RAJI_Human1.06176199
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05116015
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02639429
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01064362
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00794632
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99198416
92CTCF_21964334_Chip-Seq_Bcells_Human0.98025123
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97454659
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97323368
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97255666
96E2F1_20622854_ChIP-Seq_HELA_Human0.96721971
97SMC4_20622854_ChIP-Seq_HELA_Human0.96280225
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96247601
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96093868
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95766509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.95400737
2MP0003724_increased_susceptibility_to3.16264890
3MP0001835_abnormal_antigen_presentation3.10748011
4MP0003191_abnormal_cellular_cholesterol2.99133612
5MP0003303_peritoneal_inflammation2.92096371
6MP0002419_abnormal_innate_immunity2.86281817
7MP0005058_abnormal_lysosome_morphology2.85629601
8MP0005025_abnormal_response_to2.67641380
9MP0005451_abnormal_body_composition2.64812746
10MP0008260_abnormal_autophagy2.61605447
11MP0006082_CNS_inflammation2.48982801
12MP0000685_abnormal_immune_system2.42963199
13MP0005000_abnormal_immune_tolerance2.42018675
14MP0005671_abnormal_response_to2.41333642
15MP0009785_altered_susceptibility_to2.37910499
16MP0005464_abnormal_platelet_physiology2.35889966
17MP0001800_abnormal_humoral_immune2.33107249
18MP0003763_abnormal_thymus_physiology2.32977285
19MP0003172_abnormal_lysosome_physiology2.31603600
20MP0001790_abnormal_immune_system2.29753697
21MP0005387_immune_system_phenotype2.29753697
22MP0002420_abnormal_adaptive_immunity2.28920974
23MP0002723_abnormal_immune_serum2.27297832
24MP0001819_abnormal_immune_cell2.26935261
25MP0009278_abnormal_bone_marrow2.24160562
26MP0009333_abnormal_splenocyte_physiolog2.23111412
27MP0002452_abnormal_antigen_presenting2.23097743
28MP0002148_abnormal_hypersensitivity_rea2.20143974
29MP0000858_altered_metastatic_potential1.90536774
30MP0001533_abnormal_skeleton_physiology1.89662646
31MP0003806_abnormal_nucleotide_metabolis1.87132435
32MP0002398_abnormal_bone_marrow1.84082491
33MP0002405_respiratory_system_inflammati1.82954561
34MP0003300_gastrointestinal_ulcer1.78400974
35MP0000716_abnormal_immune_system1.76012140
36MP0004947_skin_inflammation1.75908525
37MP0002132_abnormal_respiratory_system1.71543553
38MP0009840_abnormal_foam_cell1.70810634
39MP0005397_hematopoietic_system_phenotyp1.70333184
40MP0001545_abnormal_hematopoietic_system1.70333184
41MP0001845_abnormal_inflammatory_respons1.58468919
42MP0001853_heart_inflammation1.57973756
43MP0000465_gastrointestinal_hemorrhage1.56835373
44MP0002722_abnormal_immune_system1.56253333
45MP0002429_abnormal_blood_cell1.54650330
46MP0010155_abnormal_intestine_physiology1.53756791
47MP0003075_altered_response_to1.51511991
48MP0002396_abnormal_hematopoietic_system1.48382708
49MP0008469_abnormal_protein_level1.46327040
50MP0000689_abnormal_spleen_morphology1.44704817
51MP0000703_abnormal_thymus_morphology1.43426545
52MP0002877_abnormal_melanocyte_morpholog1.32013743
53MP0000490_abnormal_crypts_of1.29406429
54MP0003828_pulmonary_edema1.27265970
55MP0003866_abnormal_defecation1.23774127
56MP0003183_abnormal_peptide_metabolism1.19934650
57MP0000343_altered_response_to1.17760106
58MP0002998_abnormal_bone_remodeling1.14490155
59MP0009764_decreased_sensitivity_to1.13353417
60MP0004381_abnormal_hair_follicle1.12401062
61MP0001873_stomach_inflammation1.10516617
62MP0001851_eye_inflammation1.07121719
63MP0004510_myositis1.02047574
64MP0004185_abnormal_adipocyte_glucose1.01240694
65MP0000604_amyloidosis0.98445737
66MP0005166_decreased_susceptibility_to0.97523908
67MP0003705_abnormal_hypodermis_morpholog0.97370339
68MP0000015_abnormal_ear_pigmentation0.97025289
69MP0003448_altered_tumor_morphology0.95757857
70MP0001849_ear_inflammation0.95078737
71MP0005390_skeleton_phenotype0.95054434
72MP0004858_abnormal_nervous_system0.92332428
73MP0004808_abnormal_hematopoietic_stem0.88357214
74MP0009763_increased_sensitivity_to0.88221134
75MP0005075_abnormal_melanosome_morpholog0.85733935
76MP0004883_abnormal_blood_vessel0.85666797
77MP0005164_abnormal_response_to0.84391635
78MP0003656_abnormal_erythrocyte_physiolo0.84133032
79MP0003453_abnormal_keratinocyte_physiol0.83270515
80MP0002019_abnormal_tumor_incidence0.79543500
81MP0005319_abnormal_enzyme/_coenzyme0.78856805
82MP0005666_abnormal_adipose_tissue0.74961083
83MP0000678_abnormal_parathyroid_gland0.74605975
84MP0005310_abnormal_salivary_gland0.74148317
85MP0003795_abnormal_bone_structure0.74044581
86MP0002166_altered_tumor_susceptibility0.73750515
87MP0002933_joint_inflammation0.72062079
88MP0005076_abnormal_cell_differentiation0.70700641
89MP0001663_abnormal_digestive_system0.70531000
90MP0003329_amyloid_beta_deposits0.68525331
91MP0003279_aneurysm0.68221902
92MP0006036_abnormal_mitochondrial_physio0.66452302
93MP0000313_abnormal_cell_death0.66305959
94MP0003566_abnormal_cell_adhesion0.66261687
95MP0005083_abnormal_biliary_tract0.65717745
96MP0001542_abnormal_bone_strength0.64238017
97MP0009765_abnormal_xenobiotic_induced0.63932117
98MP0008004_abnormal_stomach_pH0.63734565
99MP0000681_abnormal_thyroid_gland0.62385212
100MP0005501_abnormal_skin_physiology0.60985060

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.43711543
2Recurrent abscess formation (HP:0002722)5.11489840
3Recurrent bacterial skin infections (HP:0005406)4.87329063
4Abnormality of macrophages (HP:0004311)4.73418199
5Myositis (HP:0100614)4.25786953
6Elevated erythrocyte sedimentation rate (HP:0003565)4.24302424
7Chronic obstructive pulmonary disease (HP:0006510)3.98693198
8Obstructive lung disease (HP:0006536)3.98693198
9Recurrent gram-negative bacterial infections (HP:0005420)3.79911855
10Orchitis (HP:0100796)3.60370829
11Mediastinal lymphadenopathy (HP:0100721)3.46130724
12Stomatitis (HP:0010280)3.35726159
13Cellulitis (HP:0100658)3.29599302
14Recurrent skin infections (HP:0001581)3.27400498
15Recurrent fungal infections (HP:0002841)3.22896711
16Meningitis (HP:0001287)3.19840129
17Gastrointestinal infarctions (HP:0005244)3.19372264
18Petechiae (HP:0000967)3.13107129
19Abnormality of glycolipid metabolism (HP:0010969)3.13002279
20Abnormality of liposaccharide metabolism (HP:0010968)3.13002279
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.13002279
22Amyloidosis (HP:0011034)3.07875091
23Gingivitis (HP:0000230)3.06457059
24Increased IgE level (HP:0003212)3.04600489
25Urticaria (HP:0001025)3.03453599
26Optic neuritis (HP:0100653)2.93431912
27Retrobulbar optic neuritis (HP:0100654)2.93431912
28Hepatosplenomegaly (HP:0001433)2.92002623
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.89834656
30Chronic mucocutaneous candidiasis (HP:0002728)2.88454154
31Recurrent cutaneous fungal infections (HP:0011370)2.88454154
32Pustule (HP:0200039)2.81138464
33Increased cerebral lipofuscin (HP:0011813)2.77651153
34Prolonged bleeding time (HP:0003010)2.76178546
35Gastrointestinal inflammation (HP:0004386)2.74166482
36Purpura (HP:0000979)2.73956875
37Encephalitis (HP:0002383)2.70050711
38Dysostosis multiplex (HP:0000943)2.68204757
39Vertebral compression fractures (HP:0002953)2.64915753
40Inflammation of the large intestine (HP:0002037)2.62940172
41Episodic fever (HP:0001954)2.62850611
42Recurrent viral infections (HP:0004429)2.59142722
43Vasculitis (HP:0002633)2.57316258
44Chest pain (HP:0100749)2.56039982
45Increased serum ferritin (HP:0003281)2.52842136
46Increased IgM level (HP:0003496)2.50930404
47Hypertensive crisis (HP:0100735)2.48452374
48Granulocytopenia (HP:0001913)2.46810139
49Epistaxis (HP:0000421)2.39118202
50Spontaneous hematomas (HP:0007420)2.37459447
51Progressive neurologic deterioration (HP:0002344)2.36562350
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.36132556
53Loss of speech (HP:0002371)2.35115571
54Colitis (HP:0002583)2.30291244
55Vacuolated lymphocytes (HP:0001922)2.22236990
56Upper motor neuron abnormality (HP:0002127)2.20037447
57Hypergammaglobulinemia (HP:0010702)2.19375452
58Gingival bleeding (HP:0000225)2.16764975
59Keratoconjunctivitis sicca (HP:0001097)2.13782652
60Agammaglobulinemia (HP:0004432)2.13610714
61Hypochromic anemia (HP:0001931)2.13243586
62Systemic lupus erythematosus (HP:0002725)2.11157893
63Abnormality of polysaccharide metabolism (HP:0011012)2.10749655
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10749655
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10749655
66Osteomyelitis (HP:0002754)2.08134355
67Polygenic inheritance (HP:0010982)2.07075693
68Fatigue (HP:0012378)2.05494844
69Abnormality of T cells (HP:0002843)2.02713858
70Acute hepatic failure (HP:0006554)2.00613928
71Peritonitis (HP:0002586)2.00341606
72Abnormality of T cell physiology (HP:0011840)1.99791857
73Skin ulcer (HP:0200042)1.99728384
74Abnormality of iron homeostasis (HP:0011031)1.99641892
75Pulmonary infiltrates (HP:0002113)1.99333744
76Glomerulopathy (HP:0100820)1.98079818
77Panhypogammaglobulinemia (HP:0003139)1.97368103
78Ragged-red muscle fibers (HP:0003200)1.96876466
79Leukocytosis (HP:0001974)1.96505552
80Hypertriglyceridemia (HP:0002155)1.96386533
81Urinary glycosaminoglycan excretion (HP:0003541)1.95077844
82Mucopolysacchariduria (HP:0008155)1.95077844
83Sepsis (HP:0100806)1.94703352
84Hemoptysis (HP:0002105)1.93478453
85Distal lower limb muscle weakness (HP:0009053)1.93367752
86Hypochromic microcytic anemia (HP:0004840)1.93259376
87Anorexia (HP:0002039)1.92932691
88Thrombocytosis (HP:0001894)1.91487686
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91207119
90Rough bone trabeculation (HP:0100670)1.91092094
91Keratoconjunctivitis (HP:0001096)1.90990440
92Nasal polyposis (HP:0100582)1.90824644
93Interstitial pulmonary disease (HP:0006530)1.88260008
94Abnormality of the peritoneum (HP:0002585)1.88104752
95Arterial thrombosis (HP:0004420)1.87104436
96Abnormality of the nasal mucosa (HP:0000433)1.85878963
97Abnormal platelet function (HP:0011869)1.79842448
98Impaired platelet aggregation (HP:0003540)1.79842448
99Gastrointestinal stroma tumor (HP:0100723)1.79595263
100Lymphopenia (HP:0001888)1.78172169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.73498278
2ERN13.37296058
3RIPK43.22548548
4MAP2K32.87336185
5NME22.76752359
6PRPF4B2.69286858
7TESK22.65147789
8TRIB32.38351091
9MAP3K112.38230750
10IRAK42.35946206
11TYK22.35188743
12IRAK32.20057787
13BLK2.15079724
14GRK62.06243633
15SMG12.00411598
16FES1.94110440
17ZAP701.92907838
18CSK1.88712151
19TBK11.80871267
20TNK21.77746583
21MAP3K31.71056038
22TAOK11.61568329
23TESK11.59102239
24TAOK21.58715976
25TAOK31.46357700
26EPHB11.42474155
27BCKDK1.39615286
28JAK31.33837453
29BTK1.33034035
30ARAF1.30680474
31MAP3K11.24307424
32HCK1.24296211
33KDR1.22739596
34SIK31.22725009
35TXK1.19743022
36PIM21.16585117
37LRRK21.14095562
38SYK1.13575462
39CDK191.13337938
40SIK11.08420745
41CSF1R1.08385648
42PRKD21.08228444
43MAP3K141.06960878
44MAP3K131.05490443
45VRK21.04940472
46IKBKE1.04639146
47FGR1.03999451
48IRAK21.00468365
49PTK60.90492653
50LYN0.88565503
51STK100.87035281
52PDPK10.80521714
53IKBKB0.80400893
54MARK30.78813716
55PAK40.77798554
56LCK0.77335340
57ABL20.74864455
58KSR20.71819153
59MATK0.71289682
60TGFBR20.70461928
61MARK20.69837156
62JAK20.68134327
63MAP3K80.64634469
64MAPK120.64525415
65MOS0.64322891
66MAP3K60.64151113
67PDK10.62033703
68KIT0.59928664
69BMX0.59397424
70ITK0.58666143
71RPS6KA40.53592086
72IRAK10.52040455
73PKN20.50420785
74HIPK20.50226068
75BMPR20.49720387
76SIK20.49051052
77ICK0.48713197
78MAP2K20.47185959
79RAF10.46867509
80MAPKAPK20.46678119
81BRAF0.46616567
82RPS6KL10.46196442
83RPS6KC10.46196442
84CDK40.46163856
85EPHA20.46113694
86JAK10.45982731
87LIMK10.43787582
88DAPK10.42674841
89MAP2K60.42063520
90DYRK1B0.42038022
91TTN0.41685223
92CDK60.41132248
93PRKG20.40538082
94YES10.38708969
95FYN0.38120355
96MST1R0.37721526
97MAPK110.37603647
98MAPK70.36552464
99PAK10.36094661
100CDC42BPA0.36074634

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.98792849
2Osteoclast differentiation_Homo sapiens_hsa043802.81280340
3Leishmaniasis_Homo sapiens_hsa051402.74765211
4Staphylococcus aureus infection_Homo sapiens_hsa051502.33348983
5Primary immunodeficiency_Homo sapiens_hsa053402.13836671
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04989007
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04664217
8Tuberculosis_Homo sapiens_hsa051521.99684387
9Allograft rejection_Homo sapiens_hsa053301.98724511
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95337453
11Acute myeloid leukemia_Homo sapiens_hsa052211.93975701
12B cell receptor signaling pathway_Homo sapiens_hsa046621.93274055
13Graft-versus-host disease_Homo sapiens_hsa053321.90249841
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87798095
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.84016345
16Autoimmune thyroid disease_Homo sapiens_hsa053201.80900512
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77283341
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70714197
19Lysosome_Homo sapiens_hsa041421.68807055
20Antigen processing and presentation_Homo sapiens_hsa046121.68008814
21Shigellosis_Homo sapiens_hsa051311.58444013
22Hematopoietic cell lineage_Homo sapiens_hsa046401.56309084
23Malaria_Homo sapiens_hsa051441.56041115
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52227428
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50697703
26Viral myocarditis_Homo sapiens_hsa054161.50503014
27Herpes simplex infection_Homo sapiens_hsa051681.49584945
28Pentose phosphate pathway_Homo sapiens_hsa000301.48903011
29Sulfur relay system_Homo sapiens_hsa041221.46898790
30Measles_Homo sapiens_hsa051621.41482937
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.41369147
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39056523
33Phagosome_Homo sapiens_hsa041451.36957042
34Influenza A_Homo sapiens_hsa051641.34348931
35Toxoplasmosis_Homo sapiens_hsa051451.32164611
36Legionellosis_Homo sapiens_hsa051341.30939435
37Non-small cell lung cancer_Homo sapiens_hsa052231.29454959
38Salmonella infection_Homo sapiens_hsa051321.24780839
39Pertussis_Homo sapiens_hsa051331.24760953
40Apoptosis_Homo sapiens_hsa042101.24623950
41T cell receptor signaling pathway_Homo sapiens_hsa046601.24360351
42Asthma_Homo sapiens_hsa053101.23007040
43Pancreatic cancer_Homo sapiens_hsa052121.21926847
44Chronic myeloid leukemia_Homo sapiens_hsa052201.20511981
45Galactose metabolism_Homo sapiens_hsa000521.20456069
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19185389
47Hepatitis B_Homo sapiens_hsa051611.15757682
48Type I diabetes mellitus_Homo sapiens_hsa049401.14018607
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10610337
50Chemokine signaling pathway_Homo sapiens_hsa040621.08969275
51TNF signaling pathway_Homo sapiens_hsa046681.08136636
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.06447422
53VEGF signaling pathway_Homo sapiens_hsa043701.01395420
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.00438119
55Hepatitis C_Homo sapiens_hsa051600.98986477
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95072741
57Epstein-Barr virus infection_Homo sapiens_hsa051690.93783336
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93612514
59Endocytosis_Homo sapiens_hsa041440.92269631
60Fructose and mannose metabolism_Homo sapiens_hsa000510.91219879
61Notch signaling pathway_Homo sapiens_hsa043300.90710710
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88395918
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88331555
64Rheumatoid arthritis_Homo sapiens_hsa053230.87001694
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86873690
66Base excision repair_Homo sapiens_hsa034100.86123925
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86006705
68Bladder cancer_Homo sapiens_hsa052190.84450655
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.83429484
70Viral carcinogenesis_Homo sapiens_hsa052030.82597220
71Platelet activation_Homo sapiens_hsa046110.81218744
72African trypanosomiasis_Homo sapiens_hsa051430.81027175
73Ribosome_Homo sapiens_hsa030100.78852924
74HTLV-I infection_Homo sapiens_hsa051660.75410648
75DNA replication_Homo sapiens_hsa030300.74554148
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.72910733
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.72416761
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63188494
79Pyrimidine metabolism_Homo sapiens_hsa002400.62464120
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.53612092
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.52149079
82Amoebiasis_Homo sapiens_hsa051460.47449940
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.47035506
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46838331
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44513938
86Prion diseases_Homo sapiens_hsa050200.42738324
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.42583612
88HIF-1 signaling pathway_Homo sapiens_hsa040660.40815554
89* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40305388
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39766215
91Vibrio cholerae infection_Homo sapiens_hsa051100.39375201
92Renal cell carcinoma_Homo sapiens_hsa052110.37972761
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.37478663
94mTOR signaling pathway_Homo sapiens_hsa041500.35395297
95Regulation of autophagy_Homo sapiens_hsa041400.34678011
96Colorectal cancer_Homo sapiens_hsa052100.33807330
97N-Glycan biosynthesis_Homo sapiens_hsa005100.32227554
98Biosynthesis of amino acids_Homo sapiens_hsa012300.31179098
99Prolactin signaling pathway_Homo sapiens_hsa049170.29354452
100Endometrial cancer_Homo sapiens_hsa052130.28943256

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