STX11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.16255822
2NIK/NF-kappaB signaling (GO:0038061)5.02111368
3leukocyte aggregation (GO:0070486)4.58055174
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.57444224
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.57444224
6positive regulation by symbiont of host defense response (GO:0052509)4.40723136
7modulation by symbiont of host defense response (GO:0052031)4.40723136
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.40723136
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.40723136
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.40723136
11modulation by symbiont of host immune response (GO:0052553)4.40723136
12detection of other organism (GO:0098543)4.37709353
13antigen processing and presentation of endogenous antigen (GO:0019883)4.33420345
14response to peptidoglycan (GO:0032494)4.15853015
15detection of molecule of bacterial origin (GO:0032490)4.09282602
16detection of bacterium (GO:0016045)4.03502558
17regulation of interleukin-12 biosynthetic process (GO:0045075)4.03150583
18response to muramyl dipeptide (GO:0032495)4.00694118
19positive regulation of natural killer cell differentiation (GO:0032825)3.95811047
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80452435
21detection of external biotic stimulus (GO:0098581)3.79406785
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.75583153
23myeloid dendritic cell differentiation (GO:0043011)3.75179896
24tolerance induction (GO:0002507)3.74228531
25regulation of gamma-delta T cell activation (GO:0046643)3.70154005
26JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.67499091
27negative regulation of interleukin-12 production (GO:0032695)3.66018894
28microglial cell activation (GO:0001774)3.60475646
29detection of biotic stimulus (GO:0009595)3.54649811
30macrophage activation (GO:0042116)3.53138258
31regulation of gamma-delta T cell differentiation (GO:0045586)3.51854761
32regulation of B cell receptor signaling pathway (GO:0050855)3.50366038
33positive regulation of mast cell activation (GO:0033005)3.49796716
34myeloid dendritic cell activation (GO:0001773)3.49193280
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.49000351
36regulation of mast cell degranulation (GO:0043304)3.48126989
37positive regulation of humoral immune response (GO:0002922)3.44431368
38response to interleukin-15 (GO:0070672)3.44053658
39regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43382633
40* myeloid cell activation involved in immune response (GO:0002275)3.39755601
41immunoglobulin mediated immune response (GO:0016064)3.38033763
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37644431
43response to host immune response (GO:0052572)3.37644431
44respiratory burst (GO:0045730)3.35000643
45negative regulation of erythrocyte differentiation (GO:0045647)3.34506606
46negative regulation of T cell mediated immunity (GO:0002710)3.33579764
47B cell mediated immunity (GO:0019724)3.32852341
48negative regulation of cell killing (GO:0031342)3.31715146
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31715146
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.29519659
51negative thymic T cell selection (GO:0045060)3.28456700
52cellular extravasation (GO:0045123)3.27619961
53negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.27362782
54positive regulation of interferon-alpha production (GO:0032727)3.23546335
55regulation of T-helper 2 cell differentiation (GO:0045628)3.22885393
56regulation of interferon-alpha production (GO:0032647)3.22650237
57negative T cell selection (GO:0043383)3.21912606
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.21911983
59regulation of mast cell activation (GO:0033003)3.21792443
60negative regulation of cytokine production involved in immune response (GO:0002719)3.20904778
61regulation of mast cell activation involved in immune response (GO:0033006)3.20138399
62interferon-gamma-mediated signaling pathway (GO:0060333)3.19332455
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.19105235
64leukocyte cell-cell adhesion (GO:0007159)3.17767205
65macrophage activation involved in immune response (GO:0002281)3.17397518
66positive regulation of type 2 immune response (GO:0002830)3.17200622
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16554662
68response to host (GO:0075136)3.16554662
69response to host defenses (GO:0052200)3.16554662
70regulation of chronic inflammatory response (GO:0002676)3.16537399
71leukocyte migration involved in inflammatory response (GO:0002523)3.15903267
72* neutrophil activation involved in immune response (GO:0002283)3.15005176
73positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.14707229
74response to type I interferon (GO:0034340)3.13841148
75cellular response to type I interferon (GO:0071357)3.12664738
76type I interferon signaling pathway (GO:0060337)3.12664738
77lipopolysaccharide-mediated signaling pathway (GO:0031663)3.12227475
78positive regulation of antigen processing and presentation (GO:0002579)3.12141143
79regulation of interferon-beta biosynthetic process (GO:0045357)3.08386813
80positive regulation of interleukin-17 production (GO:0032740)3.06453338
81regulation of tolerance induction (GO:0002643)3.06450321
82positive regulation of chemokine biosynthetic process (GO:0045080)3.06044207
83regulation of T-helper 1 cell differentiation (GO:0045625)3.04178055
84regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03991383
85positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.03294609
86germinal center formation (GO:0002467)3.02731301
87T cell migration (GO:0072678)3.00723792
88defense response to protozoan (GO:0042832)3.00654158
89regulation of interleukin-8 biosynthetic process (GO:0045414)3.00646952
90production of molecular mediator involved in inflammatory response (GO:0002532)2.99796787
91regulation of T cell tolerance induction (GO:0002664)2.99679517
92* granulocyte activation (GO:0036230)2.99424227
93regulation of leukocyte degranulation (GO:0043300)2.99322289
94neutrophil mediated immunity (GO:0002446)2.98950610
95positive regulation of B cell differentiation (GO:0045579)2.98812258
96* neutrophil activation (GO:0042119)2.98259151
97regulation of natural killer cell differentiation (GO:0032823)2.98083800
98negative regulation of leukocyte mediated immunity (GO:0002704)2.97747942
99T-helper 1 type immune response (GO:0042088)2.97702061
100positive regulation of cytokine biosynthetic process (GO:0042108)2.97695066
101natural killer cell mediated cytotoxicity (GO:0042267)2.97274862
102natural killer cell mediated immunity (GO:0002228)2.97274862
103response to protozoan (GO:0001562)2.97146444
104positive regulation of mast cell degranulation (GO:0043306)2.96947085
105positive regulation of mast cell activation involved in immune response (GO:0033008)2.96947085
106tyrosine phosphorylation of STAT protein (GO:0007260)2.96782986
107regulation of interleukin-2 biosynthetic process (GO:0045076)2.95040385
108Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94044076
109positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93420957
110positive regulation of cellular amide metabolic process (GO:0034250)2.93148530
111cellular response to interleukin-15 (GO:0071350)2.92860409
112regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.90449006
113negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.86557985
114growth hormone receptor signaling pathway (GO:0060396)2.86485065
115dendritic cell differentiation (GO:0097028)2.86214619
116positive regulation of interleukin-2 production (GO:0032743)2.86080475
117regulation of interleukin-12 production (GO:0032655)2.85959638
118positive regulation of toll-like receptor signaling pathway (GO:0034123)2.84990203
119myeloid leukocyte mediated immunity (GO:0002444)2.84566210
120regulation of alpha-beta T cell proliferation (GO:0046640)2.83716508
121negative regulation of interleukin-6 production (GO:0032715)2.82782568
122positive regulation of interleukin-12 production (GO:0032735)2.82083321
123positive regulation of heat generation (GO:0031652)2.81551685
124* myeloid leukocyte activation (GO:0002274)2.78405569
125regulation of RIG-I signaling pathway (GO:0039535)2.77439312
126antigen processing and presentation via MHC class Ib (GO:0002475)2.77340223
127regulation of necroptotic process (GO:0060544)2.77319346
128regulation of type 2 immune response (GO:0002828)2.77112685
129regulation of B cell differentiation (GO:0045577)2.76994951
130regulation of fever generation (GO:0031620)2.76885573
131positive regulation of macrophage differentiation (GO:0045651)2.76612179
132regulation of antigen processing and presentation (GO:0002577)2.75804482
133positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74432959
134B cell receptor signaling pathway (GO:0050853)2.72910588
135leukocyte mediated cytotoxicity (GO:0001909)2.72116498
136cellular response to zinc ion (GO:0071294)2.71582585
137regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70854815
138positive regulation of immunoglobulin mediated immune response (GO:0002891)2.69924635
139positive regulation of B cell mediated immunity (GO:0002714)2.69924635
140cytokine secretion (GO:0050663)2.69542112
141negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.69525218
142regulation of growth of symbiont in host (GO:0044126)2.69525218

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.99766725
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.81580152
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.62806664
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.44716472
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.11615862
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.59224587
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41809948
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.40290722
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.37971268
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.28552524
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.25348051
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.16709100
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16310375
14IRF8_27001747_Chip-Seq_BMDM_Mouse3.15156774
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01724986
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99540897
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.87560687
18E2F7_22180533_ChIP-Seq_HELA_Human2.79852441
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.70480671
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55572977
21MYB_26560356_Chip-Seq_TH2_Human2.41636094
22MAF_26560356_Chip-Seq_TH1_Human2.36170757
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.32467060
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21060004
25RUNX_20019798_ChIP-Seq_JUKART_Human2.20220061
26MYC_22102868_ChIP-Seq_BL_Human2.19439848
27* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18996373
28* VDR_21846776_ChIP-Seq_THP-1_Human2.15118844
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14099409
30* SPI1_23547873_ChIP-Seq_NB4_Human2.10995078
31* MYB_26560356_Chip-Seq_TH1_Human2.04574385
32VDR_24763502_ChIP-Seq_THP-1_Human1.98431889
33SCL_19346495_ChIP-Seq_HPC-7_Human1.98069040
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97840501
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89448820
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.88836841
37UTX_26944678_Chip-Seq_JUKART_Human1.86746425
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80258057
39TCF7_22412390_ChIP-Seq_EML_Mouse1.80015387
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66020276
41SPI1_23127762_ChIP-Seq_K562_Human1.56436907
42* PU_27001747_Chip-Seq_BMDM_Mouse1.55728014
43GATA3_27048872_Chip-Seq_THYMUS_Human1.51589870
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49832286
45MAF_26560356_Chip-Seq_TH2_Human1.48391299
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.47332472
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47219123
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42076022
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40387197
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40079194
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39679538
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.38946339
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34030497
54KDM2B_26808549_Chip-Seq_DND41_Human1.32977128
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31753159
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30383966
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29805847
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29231659
59VDR_24787735_ChIP-Seq_THP-1_Human1.28710755
60* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28614650
61* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27453924
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24656537
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.24002218
64GATA1_22025678_ChIP-Seq_K562_Human1.23924766
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20984188
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.20962534
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20313181
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16458420
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16272293
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15762966
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15095890
72* GATA3_26560356_Chip-Seq_TH2_Human1.14243458
73* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13539935
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.12432414
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07388435
76* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04911213
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.04559225
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04508441
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03157140
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02221256
81TFEB_21752829_ChIP-Seq_HELA_Human1.01906584
82* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99601973
83* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98562208
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96452414
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96380506
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95784353
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95320607
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95092198
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95092136
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94977138
91GATA1_19941826_ChIP-Seq_K562_Human0.94601171
92* LXR_22292898_ChIP-Seq_THP-1_Human0.90560567
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90026570
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90026570
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89737292
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89163022
97NCOR1_26117541_ChIP-Seq_K562_Human0.88854796
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86900269
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86404309
100* GATA2_21666600_ChIP-Seq_HMVEC_Human0.85295548
101GATA2_19941826_ChIP-Seq_K562_Human0.84648360
102GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84464060
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83487086
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83133143
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81554288
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81216682
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78245731
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.77658563
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77540837
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77450862
111BCL6_27268052_Chip-Seq_Bcells_Human0.77079040
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77068091
113* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74691204
114BCOR_27268052_Chip-Seq_Bcells_Human0.72191496
115STAT1_20625510_ChIP-Seq_HELA_Human0.71212826
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70261334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.93723757
2MP0003303_peritoneal_inflammation3.75372428
3MP0001835_abnormal_antigen_presentation3.61157705
4MP0009785_altered_susceptibility_to3.52955458
5MP0000685_abnormal_immune_system3.36142825
6MP0001790_abnormal_immune_system3.05352118
7MP0005387_immune_system_phenotype3.05352118
8MP0005000_abnormal_immune_tolerance2.94348321
9MP0005671_abnormal_response_to2.90597664
10MP0001800_abnormal_humoral_immune2.73469659
11MP0004510_myositis2.73237058
12MP0002419_abnormal_innate_immunity2.68211822
13MP0005025_abnormal_response_to2.67847075
14MP0002148_abnormal_hypersensitivity_rea2.67529534
15MP0002452_abnormal_antigen_presenting2.57091079
16MP0003724_increased_susceptibility_to2.53776601
17MP0002723_abnormal_immune_serum2.48494709
18MP0001819_abnormal_immune_cell2.32378602
19MP0002420_abnormal_adaptive_immunity2.31694735
20MP0002405_respiratory_system_inflammati2.27771904
21MP0003300_gastrointestinal_ulcer2.21151076
22MP0001853_heart_inflammation2.18409504
23MP0001533_abnormal_skeleton_physiology2.07703951
24MP0004947_skin_inflammation2.06884058
25MP0009278_abnormal_bone_marrow2.06082382
26MP0006082_CNS_inflammation2.03506853
27MP0010155_abnormal_intestine_physiology2.02019302
28MP0003763_abnormal_thymus_physiology1.99386377
29MP0002398_abnormal_bone_marrow1.96707161
30MP0002166_altered_tumor_susceptibility1.90966333
31MP0009333_abnormal_splenocyte_physiolog1.90460833
32MP0005464_abnormal_platelet_physiology1.88309528
33MP0005397_hematopoietic_system_phenotyp1.88182153
34MP0001545_abnormal_hematopoietic_system1.88182153
35MP0000716_abnormal_immune_system1.84336897
36MP0008004_abnormal_stomach_pH1.84262936
37MP0001845_abnormal_inflammatory_respons1.83720002
38MP0003448_altered_tumor_morphology1.76660696
39MP0005451_abnormal_body_composition1.75494596
40MP0002933_joint_inflammation1.74846192
41MP0002006_tumorigenesis1.74027940
42MP0002138_abnormal_hepatobiliary_system1.72747485
43MP0005076_abnormal_cell_differentiation1.68443702
44MP0000858_altered_metastatic_potential1.63380360
45MP0009764_decreased_sensitivity_to1.62511129
46MP0010352_gastrointestinal_tract_polyps1.61677419
47MP0008260_abnormal_autophagy1.59593605
48MP0000343_altered_response_to1.59303095
49MP0000689_abnormal_spleen_morphology1.59261320
50MP0002722_abnormal_immune_system1.57212770
51MP0002396_abnormal_hematopoietic_system1.55960656
52MP0002429_abnormal_blood_cell1.55097130
53MP0001873_stomach_inflammation1.46087228
54MP0008469_abnormal_protein_level1.41527932
55MP0004808_abnormal_hematopoietic_stem1.37930838
56MP0002254_reproductive_system_inflammat1.28273750
57MP0000703_abnormal_thymus_morphology1.26945105
58MP0005058_abnormal_lysosome_morphology1.26065418
59MP0003453_abnormal_keratinocyte_physiol1.23786019
60MP0005310_abnormal_salivary_gland1.22103759
61MP0003566_abnormal_cell_adhesion1.21229642
62MP0004883_abnormal_blood_vessel1.19273638
63MP0002132_abnormal_respiratory_system1.18985619
64MP0005023_abnormal_wound_healing1.17497101
65MP0003075_altered_response_to1.16809738
66MP0002877_abnormal_melanocyte_morpholog1.12726820
67MP0003690_abnormal_glial_cell1.11945037
68MP0003866_abnormal_defecation1.09835265
69MP0002998_abnormal_bone_remodeling1.09459454
70MP0005167_abnormal_blood-brain_barrier1.09354866
71MP0003656_abnormal_erythrocyte_physiolo1.08943019
72MP0000490_abnormal_crypts_of1.08664538
73MP0003172_abnormal_lysosome_physiology1.07429385
74MP0000465_gastrointestinal_hemorrhage1.03822492
75MP0005390_skeleton_phenotype1.03111832
76MP0002332_abnormal_exercise_endurance1.03009838
77MP0010307_abnormal_tumor_latency1.02317601
78MP0003091_abnormal_cell_migration1.02000282
79MP0001851_eye_inflammation1.01493693
80MP0003183_abnormal_peptide_metabolism0.99076407
81MP0002277_abnormal_respiratory_mucosa0.95323589
82MP0003828_pulmonary_edema0.91580797
83MP0003279_aneurysm0.86540866
84MP0009765_abnormal_xenobiotic_induced0.84356614
85MP0009840_abnormal_foam_cell0.84279917
86MP0009763_increased_sensitivity_to0.84021761
87MP0005166_decreased_susceptibility_to0.83360490
88MP0003806_abnormal_nucleotide_metabolis0.82533628
89MP0000604_amyloidosis0.81861394
90MP0005164_abnormal_response_to0.79410462
91MP0001348_abnormal_lacrimal_gland0.78473845
92MP0000569_abnormal_digit_pigmentation0.78303545
93MP0002019_abnormal_tumor_incidence0.77518875
94MP0000249_abnormal_blood_vessel0.73093736
95MP0003795_abnormal_bone_structure0.71709058
96MP0003191_abnormal_cellular_cholesterol0.70704058
97MP0004381_abnormal_hair_follicle0.67801873
98MP0002009_preneoplasia0.67124174
99MP0008874_decreased_physiological_sensi0.66388332
100MP0003705_abnormal_hypodermis_morpholog0.66010209
101MP0006054_spinal_hemorrhage0.64326759
102MP0001881_abnormal_mammary_gland0.63653186
103MP0001663_abnormal_digestive_system0.62382672
104MP0001958_emphysema0.62295982
105MP0008057_abnormal_DNA_replication0.60723895
106MP0005535_abnormal_body_temperature0.60147445
107MP0000767_abnormal_smooth_muscle0.59968736
108MP0005174_abnormal_tail_pigmentation0.58437363
109MP0003221_abnormal_cardiomyocyte_apopto0.57722199
110MP0001191_abnormal_skin_condition0.56991738
111MP0001243_abnormal_dermal_layer0.56848560
112MP0001216_abnormal_epidermal_layer0.55663323
113MP0003045_fibrosis0.55441161
114MP0005621_abnormal_cell_physiology0.55184321
115MP0005165_increased_susceptibility_to0.51862582
116MP0000015_abnormal_ear_pigmentation0.51666889
117MP0004130_abnormal_muscle_cell0.50941945
118MP0000920_abnormal_myelination0.50850585
119MP0005666_abnormal_adipose_tissue0.49019568

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.75675889
2Recurrent abscess formation (HP:0002722)6.08904852
3Recurrent bacterial skin infections (HP:0005406)5.39604856
4Myositis (HP:0100614)5.21710240
5Orchitis (HP:0100796)5.04529054
6Optic neuritis (HP:0100653)5.00296904
7Retrobulbar optic neuritis (HP:0100654)5.00296904
8Elevated erythrocyte sedimentation rate (HP:0003565)4.84861091
9Stomatitis (HP:0010280)4.82407496
10Mediastinal lymphadenopathy (HP:0100721)4.69357241
11Recurrent gram-negative bacterial infections (HP:0005420)4.68294884
12Recurrent fungal infections (HP:0002841)4.56314428
13Recurrent viral infections (HP:0004429)3.78565271
14Recurrent skin infections (HP:0001581)3.74365392
15* Abnormality of macrophages (HP:0004311)3.74070196
16Obstructive lung disease (HP:0006536)3.69017588
17Chronic obstructive pulmonary disease (HP:0006510)3.69017588
18Vasculitis (HP:0002633)3.65459348
19Chronic otitis media (HP:0000389)3.60579086
20Abnormality of liposaccharide metabolism (HP:0010968)3.59239798
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.59239798
22Abnormality of glycolipid metabolism (HP:0010969)3.59239798
23Pulmonary infiltrates (HP:0002113)3.57763799
24Gingivitis (HP:0000230)3.45907293
25Keratoconjunctivitis sicca (HP:0001097)3.38776181
26Interstitial pulmonary disease (HP:0006530)3.36358628
27Recurrent cutaneous fungal infections (HP:0011370)3.35248860
28Chronic mucocutaneous candidiasis (HP:0002728)3.35248860
29Amyloidosis (HP:0011034)3.33131173
30Arterial thrombosis (HP:0004420)3.17131392
31Keratoconjunctivitis (HP:0001096)3.17075684
32Cellulitis (HP:0100658)3.16935569
33Meningitis (HP:0001287)3.13412261
34Autoimmune thrombocytopenia (HP:0001973)3.03952581
35Hemoptysis (HP:0002105)3.00040002
36Leukocytosis (HP:0001974)2.96160230
37Episodic fever (HP:0001954)2.95916910
38Nasal polyposis (HP:0100582)2.94552004
39Petechiae (HP:0000967)2.90423766
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.90337513
41Gastrointestinal infarctions (HP:0005244)2.88701358
42Increased IgM level (HP:0003496)2.87245773
43Urticaria (HP:0001025)2.87182172
44Recurrent bronchitis (HP:0002837)2.80725364
45Pustule (HP:0200039)2.80520460
46Gingival bleeding (HP:0000225)2.77970167
47Dysostosis multiplex (HP:0000943)2.75588829
48Periodontitis (HP:0000704)2.75266147
49Increased IgE level (HP:0003212)2.69745190
50Inflammation of the large intestine (HP:0002037)2.68863074
51Abnormality of T cell number (HP:0011839)2.68340872
52Loss of speech (HP:0002371)2.67594743
53Increased density of long bones (HP:0006392)2.67474064
54Abnormality of the nasal mucosa (HP:0000433)2.66724865
55IgM deficiency (HP:0002850)2.63876039
56Peritonitis (HP:0002586)2.58743119
57Gastrointestinal inflammation (HP:0004386)2.58392764
58Persistence of primary teeth (HP:0006335)2.54112678
59Abnormality of T cells (HP:0002843)2.53172486
60T lymphocytopenia (HP:0005403)2.52614833
61Systemic lupus erythematosus (HP:0002725)2.52083916
62Osteomyelitis (HP:0002754)2.50228495
63Hypergammaglobulinemia (HP:0010702)2.48744117
64Abnormal platelet volume (HP:0011876)2.48377129
65Spontaneous hematomas (HP:0007420)2.45014362
66Abnormality of T cell physiology (HP:0011840)2.44561277
67Encephalitis (HP:0002383)2.43878047
68Eosinophilia (HP:0001880)2.43292636
69Vertebral compression fractures (HP:0002953)2.40537904
70Epistaxis (HP:0000421)2.39919898
71Autoimmune hemolytic anemia (HP:0001890)2.37029435
72Osteolytic defects of the hand bones (HP:0009699)2.34175489
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.34175489
74Myocardial infarction (HP:0001658)2.33807190
75Prolonged bleeding time (HP:0003010)2.33756155
76Hematochezia (HP:0002573)2.32814041
77Vertigo (HP:0002321)2.31606027
78Thrombocytosis (HP:0001894)2.30607589
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.30375051
80Hepatosplenomegaly (HP:0001433)2.29993541
81Joint swelling (HP:0001386)2.28258710
82Skin ulcer (HP:0200042)2.26482413
83IgA deficiency (HP:0002720)2.24500896
84Disinhibition (HP:0000734)2.23324349
85Panhypogammaglobulinemia (HP:0003139)2.22610567
86Glomerulopathy (HP:0100820)2.19601707
87Chest pain (HP:0100749)2.18290291
88Increased mean platelet volume (HP:0011877)2.17518466
89Granulocytopenia (HP:0001913)2.17435295
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.15760060
91Tetraparesis (HP:0002273)2.14595814
92Emphysema (HP:0002097)2.14113869
93Colitis (HP:0002583)2.13833187
94Lymphopenia (HP:0001888)2.13089190
95Menorrhagia (HP:0000132)2.11301772
96Anorexia (HP:0002039)2.10001124
97Arthralgia (HP:0002829)2.09530776
98Amaurosis fugax (HP:0100576)2.08682286
99Gastrointestinal stroma tumor (HP:0100723)2.08416948
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08294797
101Recurrent pneumonia (HP:0006532)2.07593438
102Purpura (HP:0000979)2.04630586
103Pulmonary embolism (HP:0002204)2.03883611
104Basal ganglia calcification (HP:0002135)2.02005704
105Chronic diarrhea (HP:0002028)2.00855678
106Fatigue (HP:0012378)2.00280166
107Abnormality of the peritoneum (HP:0002585)1.99332453
108Gangrene (HP:0100758)1.98717111
109Abnormality of the pericardium (HP:0001697)1.98537327
110Abnormality of eosinophils (HP:0001879)1.98408153
111Increased cerebral lipofuscin (HP:0011813)1.98265939
112Vacuolated lymphocytes (HP:0001922)1.98044166
113Cheilitis (HP:0100825)1.96371457
114Sepsis (HP:0100806)1.95410783
115Keratitis (HP:0000491)1.95298992
116Restrictive lung disease (HP:0002091)1.95133013
117Acne (HP:0001061)1.94881254
118Abnormal platelet function (HP:0011869)1.94697131
119Impaired platelet aggregation (HP:0003540)1.94697131
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94167602
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94167602
122Abnormality of polysaccharide metabolism (HP:0011012)1.94167602
123Abnormality of the pleura (HP:0002103)1.92871751
124Recurrent lower respiratory tract infections (HP:0002783)1.92691116
125Premature loss of primary teeth (HP:0006323)1.89646797
126Thrombophlebitis (HP:0004418)1.89388555
127Abnormality of the endocardium (HP:0004306)1.85159558
128Polyneuropathy (HP:0001271)1.82571540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.22635160
2MAP4K13.45862338
3JAK33.37833754
4TBK13.27377859
5TXK3.18370214
6TYK23.10858583
7IRAK42.86480675
8PRPF4B2.77934290
9EPHB12.60573657
10IKBKE2.56039992
11IKBKB2.47819654
12IRAK32.27766024
13JAK12.14718937
14BLK2.09244651
15ZAP701.99088062
16STK101.98271724
17BMPR21.93735591
18TRIB31.84041613
19CHUK1.79067786
20FGFR41.74970626
21ERN11.72566952
22RPS6KA41.70118788
23RIPK41.69294960
24CSK1.66154512
25BTK1.65643000
26EPHA31.62979117
27KIT1.57395257
28TEC1.52665246
29MAP3K131.48322714
30ITK1.48092620
31TNK21.44777043
32HCK1.41980581
33MAP2K31.36026759
34GRK71.35837004
35IRAK21.34437257
36TAOK31.30635299
37PIM11.27694611
38FGFR31.27552872
39SYK1.26896458
40PIM21.25668368
41LRRK21.24863104
42MAP3K101.24154208
43GRK61.21316909
44LCK1.20450068
45JAK21.16657731
46PTK61.09378485
47MAP3K31.07380030
48TRPM71.04140393
49MST40.98874737
50NME20.98330647
51RIPK10.97545867
52TTN0.97220917
53CSF1R0.91081638
54CLK10.88198472
55CDC42BPA0.86690939
56FES0.85063215
57KSR20.82697653
58PKN20.81031773
59PDK10.80977593
60MARK30.80822640
61LYN0.79794560
62YES10.79334698
63FGR0.78929947
64TGFBR20.77976873
65PIK3CG0.77392618
66NEK90.77369499
67MAP3K110.76930035
68BMX0.75058450
69EEF2K0.74678587
70SIK20.74666980
71CDK120.74413748
72ALK0.73479425
73MAPK70.73113271
74IRAK10.72393702
75PDPK10.68862518
76NLK0.68143573
77MARK20.67956546
78MAPKAPK20.66229150
79KDR0.65909686
80TAOK10.63367224
81MAP3K80.62946252
82MAPK120.60766108
83STK40.59036782
84EGFR0.57164064
85MAP3K60.56927287
86TESK20.56589355
87FLT30.55939200
88SIK30.55250060
89DDR20.51258212
90PAK40.50520631
91FYN0.50468090
92MAP3K50.50429148
93PTK2B0.50408361
94PRKCQ0.49705564
95ABL10.45582299
96DAPK20.45424624
97CDK60.43264104
98MATK0.42129043
99NEK20.42055558
100MAP3K10.41803413
101SCYL20.41081651
102EIF2AK20.40825356
103PRKG20.40515192
104RPS6KA50.39954013
105SGK30.39617767
106PRKCD0.37596415
107RPS6KC10.37542943
108RPS6KL10.37542943
109PRKD20.37526510
110CAMKK20.37523364
111TESK10.35525361
112RPS6KA60.35204901
113DYRK1B0.34022815
114ABL20.33128612
115MOS0.32989838
116MAP2K60.32792243
117RPS6KA10.32557234
118HIPK20.31556215
119MAPK40.31080525
120STK30.30050606
121CDK40.30003790
122DMPK0.28964644
123STK240.28859658
124CDK190.26898674
125PDGFRB0.26792165
126MAP3K20.26375061
127ARAF0.26075636
128INSR0.25038761
129SIK10.24691929
130RAF10.24642686
131PRKCH0.23809758
132TAOK20.23455262

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.29403191
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.00214470
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.78187203
4Allograft rejection_Homo sapiens_hsa053302.57825198
5Graft-versus-host disease_Homo sapiens_hsa053322.45092945
6Osteoclast differentiation_Homo sapiens_hsa043802.44277905
7Measles_Homo sapiens_hsa051622.37027449
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.28223453
9TNF signaling pathway_Homo sapiens_hsa046682.22003755
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16839214
11Legionellosis_Homo sapiens_hsa051342.14922760
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.11552505
13Asthma_Homo sapiens_hsa053102.01485113
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.99741042
15Malaria_Homo sapiens_hsa051441.93558196
16Primary immunodeficiency_Homo sapiens_hsa053401.92543622
17Toxoplasmosis_Homo sapiens_hsa051451.90065759
18B cell receptor signaling pathway_Homo sapiens_hsa046621.81813202
19Staphylococcus aureus infection_Homo sapiens_hsa051501.80912771
20Hematopoietic cell lineage_Homo sapiens_hsa046401.80066673
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.79380506
22T cell receptor signaling pathway_Homo sapiens_hsa046601.69812928
23Tuberculosis_Homo sapiens_hsa051521.69773772
24Pertussis_Homo sapiens_hsa051331.69724575
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68992150
26Antigen processing and presentation_Homo sapiens_hsa046121.68496969
27Influenza A_Homo sapiens_hsa051641.66937380
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65195917
29Shigellosis_Homo sapiens_hsa051311.62794257
30Herpes simplex infection_Homo sapiens_hsa051681.62778948
31Apoptosis_Homo sapiens_hsa042101.59748200
32Chemokine signaling pathway_Homo sapiens_hsa040621.47758941
33Type I diabetes mellitus_Homo sapiens_hsa049401.47717284
34Viral myocarditis_Homo sapiens_hsa054161.46625827
35Autoimmune thyroid disease_Homo sapiens_hsa053201.45670466
36Hepatitis B_Homo sapiens_hsa051611.44123607
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42930514
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41957765
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37994773
40Rheumatoid arthritis_Homo sapiens_hsa053231.37016915
41Acute myeloid leukemia_Homo sapiens_hsa052211.33538180
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.26242833
43Salmonella infection_Homo sapiens_hsa051321.24723640
44Chronic myeloid leukemia_Homo sapiens_hsa052201.24549822
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17084801
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16487054
47Small cell lung cancer_Homo sapiens_hsa052221.03917866
48Epstein-Barr virus infection_Homo sapiens_hsa051691.03583377
49Hepatitis C_Homo sapiens_hsa051601.01943111
50Pancreatic cancer_Homo sapiens_hsa052121.00933762
51Prolactin signaling pathway_Homo sapiens_hsa049170.98797004
52African trypanosomiasis_Homo sapiens_hsa051430.97138939
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93862888
54Viral carcinogenesis_Homo sapiens_hsa052030.93382078
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90960656
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.90092404
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88424011
58Platelet activation_Homo sapiens_hsa046110.85785868
59HTLV-I infection_Homo sapiens_hsa051660.83878944
60Amoebiasis_Homo sapiens_hsa051460.83006399
61Phagosome_Homo sapiens_hsa041450.81398482
62p53 signaling pathway_Homo sapiens_hsa041150.80133627
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.77520549
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76716878
65VEGF signaling pathway_Homo sapiens_hsa043700.73185736
66Lysosome_Homo sapiens_hsa041420.64745230
67HIF-1 signaling pathway_Homo sapiens_hsa040660.63723868
68MicroRNAs in cancer_Homo sapiens_hsa052060.61817091
69Caffeine metabolism_Homo sapiens_hsa002320.58915597
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56814786
71Insulin resistance_Homo sapiens_hsa049310.52257572
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51384021
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.51355715
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49326897
75Proteoglycans in cancer_Homo sapiens_hsa052050.48741225
76Renal cell carcinoma_Homo sapiens_hsa052110.47749114
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47599026
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45302005
79Other glycan degradation_Homo sapiens_hsa005110.45257838
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.45236044
81GnRH signaling pathway_Homo sapiens_hsa049120.44846576
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.43783007
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41972762
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41309777
85MAPK signaling pathway_Homo sapiens_hsa040100.41166518
86* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40899769
87FoxO signaling pathway_Homo sapiens_hsa040680.40249766
88Endocytosis_Homo sapiens_hsa041440.38991709
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38067665
90Collecting duct acid secretion_Homo sapiens_hsa049660.36900793
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36703129
92Non-small cell lung cancer_Homo sapiens_hsa052230.36702970
93Focal adhesion_Homo sapiens_hsa045100.35574969
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35438135
95Notch signaling pathway_Homo sapiens_hsa043300.35153665
96Prostate cancer_Homo sapiens_hsa052150.34270122
97Endometrial cancer_Homo sapiens_hsa052130.34008685
98Choline metabolism in cancer_Homo sapiens_hsa052310.33768059
99Prion diseases_Homo sapiens_hsa050200.33442430
100Colorectal cancer_Homo sapiens_hsa052100.33372296
101mTOR signaling pathway_Homo sapiens_hsa041500.32931603
102Complement and coagulation cascades_Homo sapiens_hsa046100.32583886
103Systemic lupus erythematosus_Homo sapiens_hsa053220.29059408
104DNA replication_Homo sapiens_hsa030300.28155796
105Pathways in cancer_Homo sapiens_hsa052000.28047887
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27171570
107Bladder cancer_Homo sapiens_hsa052190.26844529
108ErbB signaling pathway_Homo sapiens_hsa040120.26030045
109Dorso-ventral axis formation_Homo sapiens_hsa043200.25851294
110One carbon pool by folate_Homo sapiens_hsa006700.24540736
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23612547
112Type II diabetes mellitus_Homo sapiens_hsa049300.21937184
113Adherens junction_Homo sapiens_hsa045200.17802355
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.16345103
115Glioma_Homo sapiens_hsa052140.14080448

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »