STX16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.71852072
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66449918
3antigen processing and presentation of endogenous antigen (GO:0019883)4.47218195
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.39555540
5thymic T cell selection (GO:0045061)4.09321190
6negative regulation of cell killing (GO:0031342)4.06843985
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.06843985
8regulation of histone H3-K27 methylation (GO:0061085)4.02154226
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00329667
10synaptic vesicle maturation (GO:0016188)3.99955075
11response to muramyl dipeptide (GO:0032495)3.97977473
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.82482058
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.76025158
14T cell selection (GO:0045058)3.66981107
15sodium ion export (GO:0071436)3.60679389
16leukocyte aggregation (GO:0070486)3.57831673
17regulation of ARF protein signal transduction (GO:0032012)3.55009540
18B cell receptor signaling pathway (GO:0050853)3.45969422
19histone H3-K4 trimethylation (GO:0080182)3.34798681
20negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.34786783
21germinal center formation (GO:0002467)3.33285177
22detection of bacterium (GO:0016045)3.27425830
23positive regulation of histone deacetylation (GO:0031065)3.26782107
24modulation by symbiont of host immune response (GO:0052553)3.23971522
25positive regulation by symbiont of host defense response (GO:0052509)3.23971522
26modulation by symbiont of host defense response (GO:0052031)3.23971522
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.23971522
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.23971522
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.23971522
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.23453277
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23375923
32detection of other organism (GO:0098543)3.22719467
33positive regulation of granulocyte differentiation (GO:0030854)3.21062989
34histone H3-K36 demethylation (GO:0070544)3.19721347
35negative regulation of granulocyte differentiation (GO:0030853)3.19206008
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18934467
37cellular potassium ion homeostasis (GO:0030007)3.18355688
38cytoskeletal anchoring at plasma membrane (GO:0007016)3.14607635
39positive regulation of Rap GTPase activity (GO:0032854)3.12895161
40regulation of ARF GTPase activity (GO:0032312)3.11312598
41regulation of granulocyte differentiation (GO:0030852)3.09736846
42activation of protein kinase A activity (GO:0034199)3.07408772
43response to interleukin-15 (GO:0070672)3.05962780
44positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05418641
45regulation of B cell receptor signaling pathway (GO:0050855)3.04779751
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03409440
47regulation of necroptotic process (GO:0060544)3.01874345
48negative regulation of T cell mediated immunity (GO:0002710)2.99372497
49synaptic vesicle docking involved in exocytosis (GO:0016081)2.98808685
50response to peptidoglycan (GO:0032494)2.96802274
51layer formation in cerebral cortex (GO:0021819)2.96175981
52negative regulation of leukocyte mediated immunity (GO:0002704)2.94592964
53positive regulation of B cell differentiation (GO:0045579)2.92990306
54tolerance induction (GO:0002507)2.92804136
55potassium ion import (GO:0010107)2.89173503
56immunoglobulin mediated immune response (GO:0016064)2.88577638
57establishment of nucleus localization (GO:0040023)2.85622825
58embryonic process involved in female pregnancy (GO:0060136)2.84150065
59positive regulation of gamma-delta T cell activation (GO:0046645)2.83258736
60regulation of synaptic vesicle exocytosis (GO:2000300)2.81657747
61regulation of gamma-delta T cell differentiation (GO:0045586)2.81136116
62vesicle transport along microtubule (GO:0047496)2.77235656
63modulation by virus of host process (GO:0019054)2.76509004
64response to type I interferon (GO:0034340)2.76335562
65regulation of extracellular matrix disassembly (GO:0010715)2.75979332
663-UTR-mediated mRNA stabilization (GO:0070935)2.74383250
67regulation of clathrin-mediated endocytosis (GO:2000369)2.74115246
68regulation of Rap GTPase activity (GO:0032317)2.72448983
69cytoplasmic mRNA processing body assembly (GO:0033962)2.72220819
70cellular extravasation (GO:0045123)2.71560176
71regulation of B cell differentiation (GO:0045577)2.69549161
72negative regulation of glycoprotein biosynthetic process (GO:0010561)2.68571943
73cellular response to type I interferon (GO:0071357)2.68330332
74type I interferon signaling pathway (GO:0060337)2.68330332
75antigen processing and presentation via MHC class Ib (GO:0002475)2.65907196
76positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.65659566
77regulation of glutamate receptor signaling pathway (GO:1900449)2.64358879
78insulin-like growth factor receptor signaling pathway (GO:0048009)2.62949769
79peptidyl-lysine dimethylation (GO:0018027)2.61409884
80neutrophil activation involved in immune response (GO:0002283)2.60740873
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.59163914
82response to host (GO:0075136)2.59163914
83response to host defenses (GO:0052200)2.59163914
84cellular response to virus (GO:0098586)2.58924757
85regulation of interferon-beta biosynthetic process (GO:0045357)2.58819143
86phospholipid scrambling (GO:0017121)2.58562748
87regulation of synapse structural plasticity (GO:0051823)2.58388489
88exploration behavior (GO:0035640)2.58074793
89glutamate secretion (GO:0014047)2.56366448
90mucosal-associated lymphoid tissue development (GO:0048537)2.55530468
91Peyers patch development (GO:0048541)2.55530468
92protein localization to endosome (GO:0036010)2.54542557
93detection of external biotic stimulus (GO:0098581)2.53844477
94mannose metabolic process (GO:0006013)2.52419516
95regulation of tolerance induction (GO:0002643)2.52195972
96peptidyl-tyrosine autophosphorylation (GO:0038083)2.52163156
97histone lysine demethylation (GO:0070076)2.52065812
98regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51861733
99suckling behavior (GO:0001967)2.51325633
100activated T cell proliferation (GO:0050798)2.51312040
101neurotransmitter secretion (GO:0007269)2.50956207
102cortical actin cytoskeleton organization (GO:0030866)2.50647549
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50068414
104regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.50013840
105modulation by symbiont of host cellular process (GO:0044068)2.49769263
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.48109375
107cellular sodium ion homeostasis (GO:0006883)2.47620234
108cerebellar Purkinje cell differentiation (GO:0021702)2.46969051
109macrophage activation involved in immune response (GO:0002281)2.46628262
110growth hormone receptor signaling pathway (GO:0060396)2.46182496
111JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46124862
112regulation of gamma-delta T cell activation (GO:0046643)2.45575602
113synaptic vesicle exocytosis (GO:0016079)2.45295977
114positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45141681
115histone demethylation (GO:0016577)2.44686913
116neuromuscular process controlling balance (GO:0050885)2.44321078
117regulation of T cell tolerance induction (GO:0002664)2.44243351
118poly(A)+ mRNA export from nucleus (GO:0016973)2.44179784
119definitive hemopoiesis (GO:0060216)2.43812041
120response to laminar fluid shear stress (GO:0034616)2.43614868
121response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43370076
122response to host immune response (GO:0052572)2.43370076
123histone H3-K9 demethylation (GO:0033169)2.43243780
124negative regulation of necroptotic process (GO:0060546)2.43160700
125antigen receptor-mediated signaling pathway (GO:0050851)2.42850357
126retrograde transport, vesicle recycling within Golgi (GO:0000301)2.42245580
127dendritic spine morphogenesis (GO:0060997)2.41811576
128gamma-aminobutyric acid transport (GO:0015812)2.41505961
129clathrin coat assembly (GO:0048268)2.40585419
130regulation of leukocyte degranulation (GO:0043300)2.40450129
131proline transport (GO:0015824)2.40091443
132negative regulation of innate immune response (GO:0045824)2.40067838
133nerve growth factor signaling pathway (GO:0038180)2.39984545
134regulation of regulatory T cell differentiation (GO:0045589)2.36788146
135positive regulation of CREB transcription factor activity (GO:0032793)2.36229491
136dendrite morphogenesis (GO:0048813)2.36048786
137positive thymic T cell selection (GO:0045059)2.36044590
138prepulse inhibition (GO:0060134)2.35342845
139regulation of myeloid leukocyte mediated immunity (GO:0002886)2.35014308
140establishment of protein localization to Golgi (GO:0072600)2.34658599
141G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.33209431
142alanine transport (GO:0032328)2.31713330
143L-amino acid import (GO:0043092)2.30427291
144ionotropic glutamate receptor signaling pathway (GO:0035235)2.30056560
145regulation of synaptic vesicle transport (GO:1902803)2.29591856
146regulation of neuronal synaptic plasticity (GO:0048168)2.29174554
147stress granule assembly (GO:0034063)2.27407032
148vocalization behavior (GO:0071625)2.26603948
149glycine transport (GO:0015816)2.24557630
150histone H3-K4 methylation (GO:0051568)2.24042093
151pre-miRNA processing (GO:0031054)2.23763937
152potassium ion homeostasis (GO:0055075)2.23233815
153regulation of beta-amyloid formation (GO:1902003)2.22119444
154mating behavior (GO:0007617)2.21637711
155cell communication by electrical coupling (GO:0010644)2.19683961
156protein targeting to Golgi (GO:0000042)2.18513738
157regulation of long-term neuronal synaptic plasticity (GO:0048169)2.17266262
158signal complex assembly (GO:0007172)2.16679979
159neuronal ion channel clustering (GO:0045161)2.15807990
160cortical cytoskeleton organization (GO:0030865)2.15623577
161activation of JUN kinase activity (GO:0007257)2.14448128
162cellular response to growth hormone stimulus (GO:0071378)2.13763829
163peptidyl-lysine trimethylation (GO:0018023)2.13217793
164regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.11959982
165peptidyl-threonine phosphorylation (GO:0018107)2.11125466
166negative regulation of cell size (GO:0045792)2.10771360
167organelle transport along microtubule (GO:0072384)2.10372876
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.09762185
169adherens junction assembly (GO:0034333)2.09571625
170negative regulation of erythrocyte differentiation (GO:0045647)2.08215985
171long-term memory (GO:0007616)2.07598198
172positive T cell selection (GO:0043368)2.07227808
173dicarboxylic acid biosynthetic process (GO:0043650)2.06324646
174negative thymic T cell selection (GO:0045060)2.05507669
175stress fiber assembly (GO:0043149)2.04933215
176peptidyl-threonine modification (GO:0018210)2.04901912
177cellular response to ethanol (GO:0071361)2.04277842
178negative T cell selection (GO:0043383)2.03847481
179negative regulation of translation, ncRNA-mediated (GO:0040033)2.02092261
180regulation of translation, ncRNA-mediated (GO:0045974)2.02092261
181negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.02092261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78172487
2DROSHA_22980978_ChIP-Seq_HELA_Human2.57207958
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54741992
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40729026
5KDM2B_26808549_Chip-Seq_DND41_Human2.30521276
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28887307
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.19759405
8EZH2_22144423_ChIP-Seq_EOC_Human2.17056727
9MYC_22102868_ChIP-Seq_BL_Human2.15920306
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06604091
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05530439
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.00475838
13* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99511033
14RUNX1_22412390_ChIP-Seq_EML_Mouse1.96336528
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96198315
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.94133689
17* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.88204252
18DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.82676940
19KDM2B_26808549_Chip-Seq_K562_Human1.82637530
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81606479
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.81250317
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79765146
23VDR_21846776_ChIP-Seq_THP-1_Human1.79569022
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78302833
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77535167
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76899730
27MAF_26560356_Chip-Seq_TH2_Human1.74855567
28KDM2B_26808549_Chip-Seq_JURKAT_Human1.73929775
29GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70818997
30MYB_26560356_Chip-Seq_TH2_Human1.67344729
31* MYB_26560356_Chip-Seq_TH1_Human1.64883527
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61026309
33* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58976947
34RUNX_20019798_ChIP-Seq_JUKART_Human1.56842233
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55873613
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55799658
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54555426
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53697509
39SPI1_23127762_ChIP-Seq_K562_Human1.49176205
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46417891
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45356866
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43686292
43LXR_22292898_ChIP-Seq_THP-1_Human1.43198859
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42376575
45* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42274232
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41557492
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39336121
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38770004
49SCL_19346495_ChIP-Seq_HPC-7_Human1.38106499
50VDR_24763502_ChIP-Seq_THP-1_Human1.38000459
51CIITA_25753668_ChIP-Seq_RAJI_Human1.37651724
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36824268
53SPI1_23547873_ChIP-Seq_NB4_Human1.35622464
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34132321
55TP53_16413492_ChIP-PET_HCT116_Human1.33650371
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33588327
57NCOR1_26117541_ChIP-Seq_K562_Human1.32913839
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31678850
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31452713
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31085234
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30804393
62* SMC4_20622854_ChIP-Seq_HELA_Human1.30332095
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29960801
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29443474
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.26109755
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25772665
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25703033
68GATA1_19941826_ChIP-Seq_K562_Human1.24758215
69MAF_26560356_Chip-Seq_TH1_Human1.23094243
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22832046
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22832046
72P68_20966046_ChIP-Seq_HELA_Human1.21901731
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21410871
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.21380377
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21244116
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20644508
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.20220504
78* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19246518
79UTX_26944678_Chip-Seq_JUKART_Human1.19122854
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18946437
81* FOXA2_19822575_ChIP-Seq_HepG2_Human1.17908014
82GATA1_22025678_ChIP-Seq_K562_Human1.17599507
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17500016
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.17431242
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17249650
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16994085
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16903702
88* ELK3_25401928_ChIP-Seq_HUVEC_Human1.16619494
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.12795658
90* GATA3_27048872_Chip-Seq_THYMUS_Human1.12360205
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11807922
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11422552
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.09732462
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09546642
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08849879
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08734059
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.08134817
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.08001690
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07229082
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07170979
101REST_21632747_ChIP-Seq_MESCs_Mouse1.07053998
102* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06611368
103TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05816300
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05539073
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04283197
106AR_21572438_ChIP-Seq_LNCaP_Human1.03917952
107* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03883609
108PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03616235
109* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03419485
110* CREB1_26743006_Chip-Seq_LNCaP_Human1.03094167
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.03031379
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02969715
113JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02958340
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02346703
115AR_19668381_ChIP-Seq_PC3_Human1.00406007
116IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99890219
117SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99070272
118GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98765255
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98636860
120PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98488234
121JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98136117
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.98061023
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97694924
124PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97457962
125PU_27001747_Chip-Seq_BMDM_Mouse0.97349603
126RNF2_27304074_Chip-Seq_ESCs_Mouse0.97191080
127CLOCK_20551151_ChIP-Seq_293T_Human0.96446146
128AHR_22903824_ChIP-Seq_MCF-7_Human0.95495282
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.94770535
130SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94743271
131RXR_22158963_ChIP-Seq_LIVER_Mouse0.93607317
132* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93423814
133BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93305729
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92854022
135NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92493691
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92467791
137SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92286348
138* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92196299
139BCOR_27268052_Chip-Seq_Bcells_Human0.91631320
140RXR_22108803_ChIP-Seq_LS180_Human0.91204347
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.91051759
142RACK7_27058665_Chip-Seq_MCF-7_Human0.89847500
143GATA2_19941826_ChIP-Seq_K562_Human0.89566047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.03576345
2MP0000569_abnormal_digit_pigmentation3.85592088
3MP0003763_abnormal_thymus_physiology2.90471040
4MP0003172_abnormal_lysosome_physiology2.54761289
5MP0003635_abnormal_synaptic_transmissio2.53442051
6MP0003303_peritoneal_inflammation2.52350319
7MP0003300_gastrointestinal_ulcer2.44045256
8MP0008961_abnormal_basal_metabolism2.42621238
9MP0009780_abnormal_chondrocyte_physiolo2.24097789
10MP0002909_abnormal_adrenal_gland2.23695296
11MP0002009_preneoplasia2.23389453
12MP0003191_abnormal_cellular_cholesterol2.19398755
13MP0008260_abnormal_autophagy2.14431079
14MP0003724_increased_susceptibility_to2.10369946
15MP0004130_abnormal_muscle_cell2.08277285
16MP0005000_abnormal_immune_tolerance2.05064456
17MP0002419_abnormal_innate_immunity2.03851917
18MP0005409_darkened_coat_color2.03352743
19MP0005025_abnormal_response_to2.02678513
20MP0010234_abnormal_vibrissa_follicle1.99319284
21MP0002420_abnormal_adaptive_immunity1.97091355
22MP0002723_abnormal_immune_serum1.95937480
23MP0002398_abnormal_bone_marrow1.95578759
24MP0001819_abnormal_immune_cell1.95356523
25MP0005076_abnormal_cell_differentiation1.94695616
26MP0004381_abnormal_hair_follicle1.91530420
27MP0000703_abnormal_thymus_morphology1.90514007
28MP0003705_abnormal_hypodermis_morpholog1.88283260
29MP0003045_fibrosis1.86751931
30MP0003690_abnormal_glial_cell1.85227100
31MP0008569_lethality_at_weaning1.83983826
32MP0004264_abnormal_extraembryonic_tissu1.82664531
33MP0002452_abnormal_antigen_presenting1.78009602
34MP0004510_myositis1.77199527
35MP0004270_analgesia1.75271713
36MP0010155_abnormal_intestine_physiology1.75201731
37MP0009745_abnormal_behavioral_response1.74375068
38MP0002064_seizures1.73364393
39MP0002063_abnormal_learning/memory/cond1.73183894
40MP0000716_abnormal_immune_system1.72883110
41MP0002405_respiratory_system_inflammati1.71807993
42MP0005671_abnormal_response_to1.67065915
43MP0002722_abnormal_immune_system1.61859870
44MP0002166_altered_tumor_susceptibility1.59684037
45MP0003866_abnormal_defecation1.58272844
46MP0003183_abnormal_peptide_metabolism1.55101627
47MP0002822_catalepsy1.52186453
48MP0000689_abnormal_spleen_morphology1.51261710
49MP0005451_abnormal_body_composition1.50013460
50MP0009278_abnormal_bone_marrow1.45828214
51MP0001873_stomach_inflammation1.44191829
52MP0005167_abnormal_blood-brain_barrier1.44122325
53MP0009333_abnormal_splenocyte_physiolog1.44037209
54MP0009046_muscle_twitch1.43730111
55MP0002132_abnormal_respiratory_system1.43444105
56MP0003329_amyloid_beta_deposits1.43340627
57MP0002429_abnormal_blood_cell1.42736292
58MP0001533_abnormal_skeleton_physiology1.42571662
59MP0003075_altered_response_to1.42526597
60MP0008874_decreased_physiological_sensi1.40948375
61MP0001851_eye_inflammation1.39817075
62MP0000858_altered_metastatic_potential1.36707768
63MP0004185_abnormal_adipocyte_glucose1.35957534
64MP0000003_abnormal_adipose_tissue1.33538731
65MP0005058_abnormal_lysosome_morphology1.32077492
66MP0004885_abnormal_endolymph1.30269635
67MP0003283_abnormal_digestive_organ1.30213988
68MP0003787_abnormal_imprinting1.28047776
69MP0002572_abnormal_emotion/affect_behav1.27101140
70MP0003828_pulmonary_edema1.27050991
71MP0003633_abnormal_nervous_system1.26713934
72MP0005375_adipose_tissue_phenotype1.26584391
73MP0004858_abnormal_nervous_system1.26370380
74MP0001853_heart_inflammation1.25086580
75MP0004811_abnormal_neuron_physiology1.24054412
76MP0001501_abnormal_sleep_pattern1.23075749
77MP0002998_abnormal_bone_remodeling1.21537269
78MP0000685_abnormal_immune_system1.20704836
79MP0002933_joint_inflammation1.19819533
80MP0000604_amyloidosis1.17868114
81MP0000920_abnormal_myelination1.17559905
82MP0005666_abnormal_adipose_tissue1.16171145
83MP0009785_altered_susceptibility_to1.15524715
84MP0005423_abnormal_somatic_nervous1.15328676
85MP0001486_abnormal_startle_reflex1.14326263
86MP0001545_abnormal_hematopoietic_system1.14302680
87MP0005397_hematopoietic_system_phenotyp1.14302680
88MP0000013_abnormal_adipose_tissue1.11989681
89MP0001849_ear_inflammation1.09695710
90MP0001845_abnormal_inflammatory_respons1.08916540
91MP0005075_abnormal_melanosome_morpholog1.04923460
92MP0003453_abnormal_keratinocyte_physiol1.02967620
93MP0002272_abnormal_nervous_system1.02588806
94MP0001299_abnormal_eye_distance/1.02577509
95MP0003122_maternal_imprinting1.01167318
96MP0000733_abnormal_muscle_development0.99964502
97MP0000747_muscle_weakness0.99542267
98MP0002006_tumorigenesis0.98035399
99MP0002148_abnormal_hypersensitivity_rea0.98010147
100MP0002928_abnormal_bile_duct0.94608236
101MP0004808_abnormal_hematopoietic_stem0.93723307
102MP0002089_abnormal_postnatal_growth/wei0.93429877
103MP0002971_abnormal_brown_adipose0.92435845
104MP0008469_abnormal_protein_level0.92141196
105MP0009115_abnormal_fat_cell0.92014801
106MP0003631_nervous_system_phenotype0.91719451
107MP0001800_abnormal_humoral_immune0.91669999
108MP0005387_immune_system_phenotype0.91562544
109MP0001790_abnormal_immune_system0.91562544
110MP0005623_abnormal_meninges_morphology0.91342843
111MP0005621_abnormal_cell_physiology0.90496261
112MP0005535_abnormal_body_temperature0.90488707
113MP0003656_abnormal_erythrocyte_physiolo0.90236233
114MP0004883_abnormal_blood_vessel0.88069746
115MP0000751_myopathy0.87895320
116MP0005464_abnormal_platelet_physiology0.85333646
117MP0002067_abnormal_sensory_capabilities0.84606575
118MP0002877_abnormal_melanocyte_morpholog0.83191978
119MP0004947_skin_inflammation0.83087575
120MP0010352_gastrointestinal_tract_polyps0.82696250
121MP0003091_abnormal_cell_migration0.82245745
122MP0000955_abnormal_spinal_cord0.80920845
123MP0001968_abnormal_touch/_nociception0.80824194
124MP0004924_abnormal_behavior0.79169032
125MP0005386_behavior/neurological_phenoty0.79169032
126MP0004782_abnormal_surfactant_physiolog0.78661419
127MP0003123_paternal_imprinting0.77905365
128MP0005166_decreased_susceptibility_to0.77333813
129MP0002396_abnormal_hematopoietic_system0.76579219
130MP0001348_abnormal_lacrimal_gland0.76507781
131MP0005645_abnormal_hypothalamus_physiol0.75968124
132MP0002090_abnormal_vision0.75662973
133MP0003252_abnormal_bile_duct0.75226422
134MP0003879_abnormal_hair_cell0.75224236
135MP0001502_abnormal_circadian_rhythm0.75037139
136MP0003566_abnormal_cell_adhesion0.74622767
137MP0008770_decreased_survivor_rate0.74490826
138MP0003959_abnormal_lean_body0.74224495
139MP0002078_abnormal_glucose_homeostasis0.73323892
140MP0001440_abnormal_grooming_behavior0.73272391
141MP0003634_abnormal_glial_cell0.72709207
142MP0004087_abnormal_muscle_fiber0.72562300
143MP0006082_CNS_inflammation0.72178546
144MP0002970_abnormal_white_adipose0.72050779
145MP0005023_abnormal_wound_healing0.71487421
146MP0002733_abnormal_thermal_nociception0.71179368
147MP0003632_abnormal_nervous_system0.70986618
148MP0003436_decreased_susceptibility_to0.70813088
149MP0001835_abnormal_antigen_presentation0.69483371
150MP0002066_abnormal_motor_capabilities/c0.69278987
151MP0010630_abnormal_cardiac_muscle0.69245130
152MP0002069_abnormal_eating/drinking_beha0.67905342
153MP0005310_abnormal_salivary_gland0.67809445
154MP0002557_abnormal_social/conspecific_i0.67556912
155MP0001915_intracranial_hemorrhage0.67312992
156MP0001944_abnormal_pancreas_morphology0.66602781
157MP0000249_abnormal_blood_vessel0.64766349
158MP0002138_abnormal_hepatobiliary_system0.64726708
159MP0000609_abnormal_liver_physiology0.64699283
160MP0000490_abnormal_crypts_of0.64128294
161MP0000465_gastrointestinal_hemorrhage0.63946455
162MP0002019_abnormal_tumor_incidence0.63699107
163MP0009840_abnormal_foam_cell0.63259624
164MP0005390_skeleton_phenotype0.62899403

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.93002980
2Macroorchidism (HP:0000053)3.90756921
3Abnormal delayed hypersensitivity skin test (HP:0002963)3.44810044
4Myositis (HP:0100614)3.32146276
5Cerebral aneurysm (HP:0004944)3.23623469
6Hyperacusis (HP:0010780)3.21984272
7Supranuclear gaze palsy (HP:0000605)3.06449737
8Action tremor (HP:0002345)3.00813217
9Pustule (HP:0200039)3.00008501
10Prolonged bleeding time (HP:0003010)2.97681986
11Recurrent abscess formation (HP:0002722)2.93292010
12Recurrent fungal infections (HP:0002841)2.88865759
13Recurrent bacterial skin infections (HP:0005406)2.86285052
14Deep venous thrombosis (HP:0002625)2.79003389
15Obstructive sleep apnea (HP:0002870)2.78729654
16Meningitis (HP:0001287)2.77987301
17Orchitis (HP:0100796)2.77541476
18Increased IgE level (HP:0003212)2.76370891
19Visual hallucinations (HP:0002367)2.75312445
20Abnormality of the fingertips (HP:0001211)2.71131979
21Gastrointestinal infarctions (HP:0005244)2.70399365
22Polygenic inheritance (HP:0010982)2.67062168
23Elevated erythrocyte sedimentation rate (HP:0003565)2.65432744
24Gingival bleeding (HP:0000225)2.63955050
25Focal seizures (HP:0007359)2.63892072
26Retrobulbar optic neuritis (HP:0100654)2.62354738
27Optic neuritis (HP:0100653)2.62354738
28Abnormality of macrophages (HP:0004311)2.60120589
29Flat acetabular roof (HP:0003180)2.60110995
30Elfin facies (HP:0004428)2.54224583
31Broad face (HP:0000283)2.53704752
32Hemiplegia (HP:0002301)2.53131340
33Insomnia (HP:0100785)2.52012322
34Vasculitis (HP:0002633)2.48862037
35Agammaglobulinemia (HP:0004432)2.47656331
36Epistaxis (HP:0000421)2.45792460
37Recurrent gram-negative bacterial infections (HP:0005420)2.43874449
38Papilledema (HP:0001085)2.41273992
39Slow saccadic eye movements (HP:0000514)2.40988105
40Postural instability (HP:0002172)2.38122867
41Dysmetric saccades (HP:0000641)2.35306612
42Chronic mucocutaneous candidiasis (HP:0002728)2.34206399
43Recurrent cutaneous fungal infections (HP:0011370)2.34206399
44Vertebral arch anomaly (HP:0008438)2.33850978
45Hematochezia (HP:0002573)2.31161540
46Hemorrhage of the eye (HP:0011885)2.30361597
47Recurrent skin infections (HP:0001581)2.30025673
48Pointed chin (HP:0000307)2.29074276
49Colitis (HP:0002583)2.29073927
50Viral hepatitis (HP:0006562)2.28565724
51Mediastinal lymphadenopathy (HP:0100721)2.27266445
52Myokymia (HP:0002411)2.26573905
53Impaired social interactions (HP:0000735)2.24805758
54Abnormal social behavior (HP:0012433)2.24805758
55Focal motor seizures (HP:0011153)2.24371254
56Neoplasm of the heart (HP:0100544)2.19809323
57Ankyloglossia (HP:0010296)2.19382054
58Narrow palate (HP:0000189)2.17230986
59Chronic obstructive pulmonary disease (HP:0006510)2.17066216
60Obstructive lung disease (HP:0006536)2.17066216
61Dislocated radial head (HP:0003083)2.16652810
62J-shaped sella turcica (HP:0002680)2.15254402
63Urinary bladder sphincter dysfunction (HP:0002839)2.14857186
64Dysostosis multiplex (HP:0000943)2.13652965
65Upper limb amyotrophy (HP:0009129)2.13613671
66Distal upper limb amyotrophy (HP:0007149)2.13613671
67Enlarged penis (HP:0000040)2.13604377
68Asymmetry of the thorax (HP:0001555)2.11099710
69Postural tremor (HP:0002174)2.09372011
70Aortic aneurysm (HP:0004942)2.08934096
71Striae distensae (HP:0001065)2.08478945
72Renovascular hypertension (HP:0100817)2.08003140
73Encephalitis (HP:0002383)2.07582249
74Abnormality of the lower motor neuron (HP:0002366)2.07489325
75Spontaneous hematomas (HP:0007420)2.05068289
76Abnormality of the radial head (HP:0003995)2.04724304
77Granulocytopenia (HP:0001913)2.03061841
78Abnormality of oral frenula (HP:0000190)2.02723453
79Heterotopia (HP:0002282)2.02490419
80Menorrhagia (HP:0000132)2.02256002
81Cerebral inclusion bodies (HP:0100314)2.02157860
82Urinary glycosaminoglycan excretion (HP:0003541)2.02079345
83Mucopolysacchariduria (HP:0008155)2.02079345
84Gingivitis (HP:0000230)2.01203873
85Mitral valve prolapse (HP:0001634)2.00280696
86Depression (HP:0000716)1.99841501
87Hypochromic anemia (HP:0001931)1.98941060
88Broad palm (HP:0001169)1.98875841
89Arterial thrombosis (HP:0004420)1.98630938
90Increased cerebral lipofuscin (HP:0011813)1.97745851
91Aneurysm (HP:0002617)1.96821934
92Intention tremor (HP:0002080)1.96667743
93Obsessive-compulsive behavior (HP:0000722)1.96154832
94Pulmonary infiltrates (HP:0002113)1.95864386
95Pulmonary embolism (HP:0002204)1.95714212
96Urethral obstruction (HP:0000796)1.95369213
97Abnormality of the peritoneum (HP:0002585)1.94962279
98Abnormality of polysaccharide metabolism (HP:0011012)1.94926492
99Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94926492
100Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94926492
101Resting tremor (HP:0002322)1.94855522
102Difficulty running (HP:0009046)1.93823962
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93766261
104Chest pain (HP:0100749)1.93658023
105Bowel diverticulosis (HP:0005222)1.91872318
106Segmental peripheral demyelination/remyelination (HP:0003481)1.91622500
107Metaphyseal cupping (HP:0003021)1.90720502
108Gastrointestinal stroma tumor (HP:0100723)1.90159582
109Urticaria (HP:0001025)1.89500350
110Abnormality of the common coagulation pathway (HP:0010990)1.89292577
111Genetic anticipation (HP:0003743)1.88924526
112Impaired vibration sensation in the lower limbs (HP:0002166)1.88490523
113Neuronal loss in central nervous system (HP:0002529)1.87610201
114Abnormality of T cells (HP:0002843)1.86939311
115Gastrointestinal inflammation (HP:0004386)1.86390397
116Frequent falls (HP:0002359)1.86277476
117Urinary urgency (HP:0000012)1.85966047
118Broad metatarsal (HP:0001783)1.85794608
119Hypercortisolism (HP:0001578)1.85501415
120Abnormality of T cell physiology (HP:0011840)1.84658710
121Abnormality of T cell number (HP:0011839)1.84529933
122Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83477985
123Syringomyelia (HP:0003396)1.81967069
124Spinal cord lesions (HP:0100561)1.81967069
125T lymphocytopenia (HP:0005403)1.81893685
126Inflammation of the large intestine (HP:0002037)1.81768674
127Impaired smooth pursuit (HP:0007772)1.81432865
128Overriding aorta (HP:0002623)1.81256763
129Purpura (HP:0000979)1.80370133
130Seborrheic dermatitis (HP:0001051)1.79823885
131Cervical subluxation (HP:0003308)1.79223155
132Shallow orbits (HP:0000586)1.78168959
133Mitral stenosis (HP:0001718)1.78115442
134Deep palmar crease (HP:0006191)1.77057843
135Verrucae (HP:0200043)1.76908091
136Papilloma (HP:0012740)1.76908091
137Basal cell carcinoma (HP:0002671)1.76712330
138Growth hormone excess (HP:0000845)1.76172922
139Ankle clonus (HP:0011448)1.75423080
140Insidious onset (HP:0003587)1.75287617
141Termporal pattern (HP:0011008)1.75287617
142Cheilitis (HP:0100825)1.74938764
143Recurrent viral infections (HP:0004429)1.74690327
144Rapidly progressive (HP:0003678)1.74172759
145Keratoconjunctivitis sicca (HP:0001097)1.73784140
146Poor eye contact (HP:0000817)1.73616816
147Arterial tortuosity (HP:0005116)1.73003271
148Stomatitis (HP:0010280)1.72875487
149Hand muscle atrophy (HP:0009130)1.71395246
150Inappropriate behavior (HP:0000719)1.71381036
151Apathy (HP:0000741)1.71364084
152Disproportionate tall stature (HP:0001519)1.71188174
153Pseudobulbar signs (HP:0002200)1.69415166
154Neurofibrillary tangles (HP:0002185)1.69292206
155Hemoptysis (HP:0002105)1.69006783
156Fatigue (HP:0012378)1.68748370
157Subacute progressive viral hepatitis (HP:0006572)1.67759606
158Dilatation of the ascending aorta (HP:0005111)1.67559625
159Aqueductal stenosis (HP:0002410)1.66705882
160Restrictive lung disease (HP:0002091)1.66603520
161Dysmetria (HP:0001310)1.66053102
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65961740
163Abnormality of ocular smooth pursuit (HP:0000617)1.65722710
164Recurrent bronchitis (HP:0002837)1.65680357
165Interstitial pulmonary disease (HP:0006530)1.65167300
166Renal duplication (HP:0000075)1.64635387
167Spastic gait (HP:0002064)1.63262722
168Absence seizures (HP:0002121)1.62606627
169Absent frontal sinuses (HP:0002688)1.62398321
170Truncal ataxia (HP:0002078)1.61651594
171Turricephaly (HP:0000262)1.60293562
172Cellulitis (HP:0100658)1.59521126
173Chronic otitis media (HP:0000389)1.59216860
174Progressive cerebellar ataxia (HP:0002073)1.56675098
175Psychosis (HP:0000709)1.54767450
176Febrile seizures (HP:0002373)1.54179954
177Diplopia (HP:0000651)1.53760345
178Abnormality of binocular vision (HP:0011514)1.53760345
179Atonic seizures (HP:0010819)1.53086029
180Dysdiadochokinesis (HP:0002075)1.52165577
181Panhypogammaglobulinemia (HP:0003139)1.52088153
182Lower limb amyotrophy (HP:0007210)1.51708208
183Diminished motivation (HP:0000745)1.50622360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK22.94178030
2TRIB32.93234839
3PKN22.85321246
4EEF2K2.38648211
5SIK12.25386724
6MAP3K132.23024376
7CAMK1G2.17617325
8MAP3K92.13788024
9RIPK12.05395633
10MAP2K32.04802868
11CAMK1D1.81849855
12FES1.80388741
13NTRK31.69491767
14MAP3K141.69340596
15ZAP701.66342862
16DAPK21.66098807
17SMG11.63101372
18PTK61.59885447
19IRAK41.58631091
20CAMKK11.58362656
21MAP3K71.56254817
22JAK11.54875815
23PRKD31.53046538
24MAP3K101.52381702
25KSR21.49357233
26RIPK41.44400732
27RET1.43975244
28CDK121.41112645
29ALK1.36800431
30EPHB11.34218037
31ERN11.29482864
32PRKCH1.28606074
33TYRO31.28493126
34TYK21.25606794
35SIK31.25116081
36MAP3K41.23903799
37CSF1R1.21409317
38STK381.20836612
39PAK61.19714509
40PDGFRA1.18559707
41TBK11.15804305
42IKBKE1.15728033
43MARK21.15605597
44SCYL21.15428443
45WNK11.14931278
46SGK31.13891832
47FGFR31.13772124
48MAP3K21.12780204
49MINK11.10107650
50BLK1.07186402
51MAP3K31.05638989
52ICK1.05487338
53MAP2K41.05458667
54DMPK1.03805675
55MAP2K21.01341071
56FGFR21.00898066
57TGFBR20.97595231
58YES10.97489169
59EPHA40.96174278
60MAP4K10.95320089
61NTRK20.95141085
62PDGFRB0.94975502
63PDK10.91930085
64HCK0.91783829
65STK110.91741575
66NTRK10.91726975
67TTN0.90604048
68MAPK110.90096534
69FGFR40.89655187
70JAK20.89373991
71BRD40.86764878
72LRRK20.85761004
73TAOK10.85438189
74KIT0.81459206
75CAMK10.81188150
76HIPK20.80404046
77MAPK70.79986004
78LCK0.77009130
79CDK50.74978598
80CDK60.74918877
81PDPK10.74007808
82CDK40.73536404
83TAOK30.72884135
84MTOR0.71539433
85MAPK120.70949871
86CDC42BPA0.70650645
87UHMK10.67672092
88FYN0.67666305
89MAP2K60.67256967
90PRKD10.66655262
91PTK20.66595985
92CHUK0.66102740
93SGK20.63319336
94PRPF4B0.61855923
95SGK10.61643599
96RPS6KA20.61381525
97TEC0.61282596
98RPS6KB20.59464047
99GRK60.58777532
100IKBKB0.58640009
101ITK0.58334704
102IRAK20.58309749
103BMX0.57939613
104TXK0.56994830
105PRKD20.56535523
106TNK20.56267066
107DYRK1B0.55662372
108LYN0.54485085
109SYK0.53791800
110CAMKK20.53567113
111PASK0.53237604
112NEK60.52971599
113CAMK40.52810921
114CSK0.52555628
115PIK3CA0.51883134
116SGK2230.51691271
117SGK4940.51691271
118RPS6KC10.50755583
119RPS6KL10.50755583
120MAP3K60.48187538
121JAK30.47034290
122FGR0.46542433
123STK100.46391162
124SRC0.46228499
125MAPK100.45178138
126RPS6KA30.44313988
127MARK30.43730769
128ERBB20.42836621
129BTK0.42456812
130INSRR0.41938839
131EPHA20.41110989
132FGFR10.40832250
133PAK20.40771246
134MAP3K10.40316080
135FLT30.39676247
136IRAK30.38200303

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.20820718
2Nitrogen metabolism_Homo sapiens_hsa009102.08490602
3Type II diabetes mellitus_Homo sapiens_hsa049301.76430815
4Long-term potentiation_Homo sapiens_hsa047201.56661034
5Staphylococcus aureus infection_Homo sapiens_hsa051501.55473820
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51513451
7Allograft rejection_Homo sapiens_hsa053301.51035168
8Circadian entrainment_Homo sapiens_hsa047131.48859750
9Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47985830
10Notch signaling pathway_Homo sapiens_hsa043301.45534433
11Olfactory transduction_Homo sapiens_hsa047401.43855111
12Autoimmune thyroid disease_Homo sapiens_hsa053201.42184015
13Graft-versus-host disease_Homo sapiens_hsa053321.40363226
14Gastric acid secretion_Homo sapiens_hsa049711.40361431
15B cell receptor signaling pathway_Homo sapiens_hsa046621.36996279
16Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35721472
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35568947
18Glutamatergic synapse_Homo sapiens_hsa047241.34816531
19GABAergic synapse_Homo sapiens_hsa047271.33901132
20Salivary secretion_Homo sapiens_hsa049701.33571161
21Influenza A_Homo sapiens_hsa051641.32934211
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30597057
23Morphine addiction_Homo sapiens_hsa050321.30520201
24Measles_Homo sapiens_hsa051621.30298181
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28059094
26Glioma_Homo sapiens_hsa052141.28048962
27Cholinergic synapse_Homo sapiens_hsa047251.27250310
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26439647
29Synaptic vesicle cycle_Homo sapiens_hsa047211.26428908
30Insulin secretion_Homo sapiens_hsa049111.26413582
31Chronic myeloid leukemia_Homo sapiens_hsa052201.25480267
32Renin secretion_Homo sapiens_hsa049241.24735646
33mTOR signaling pathway_Homo sapiens_hsa041501.22409192
34Hepatitis B_Homo sapiens_hsa051611.22323592
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20983910
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20041818
37Hepatitis C_Homo sapiens_hsa051601.19083937
38Dopaminergic synapse_Homo sapiens_hsa047281.18834062
39Type I diabetes mellitus_Homo sapiens_hsa049401.18684230
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.16909235
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16681402
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16256464
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16230509
44GnRH signaling pathway_Homo sapiens_hsa049121.15925843
45Dorso-ventral axis formation_Homo sapiens_hsa043201.15803715
46Estrogen signaling pathway_Homo sapiens_hsa049151.13020129
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.11690308
48Oxytocin signaling pathway_Homo sapiens_hsa049211.11301310
49Lysine degradation_Homo sapiens_hsa003101.10439854
50Osteoclast differentiation_Homo sapiens_hsa043801.10247638
51Amphetamine addiction_Homo sapiens_hsa050311.09835243
52Herpes simplex infection_Homo sapiens_hsa051681.09801487
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.09710391
54Non-small cell lung cancer_Homo sapiens_hsa052231.09647620
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09137444
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04348725
57TNF signaling pathway_Homo sapiens_hsa046681.03967931
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03305487
59Insulin resistance_Homo sapiens_hsa049311.01531560
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.01454941
61Cocaine addiction_Homo sapiens_hsa050301.01437580
62Platelet activation_Homo sapiens_hsa046111.01304622
63Phospholipase D signaling pathway_Homo sapiens_hsa040721.00584403
64Endometrial cancer_Homo sapiens_hsa052131.00403617
65Chemokine signaling pathway_Homo sapiens_hsa040621.00208665
66Thyroid cancer_Homo sapiens_hsa052160.99350834
67Asthma_Homo sapiens_hsa053100.96477678
68Viral myocarditis_Homo sapiens_hsa054160.95939794
69Nicotine addiction_Homo sapiens_hsa050330.95430463
70Long-term depression_Homo sapiens_hsa047300.94770770
71ErbB signaling pathway_Homo sapiens_hsa040120.94294905
72VEGF signaling pathway_Homo sapiens_hsa043700.94272317
73cAMP signaling pathway_Homo sapiens_hsa040240.92932768
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92326886
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92054187
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.91080866
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90466757
78Pancreatic secretion_Homo sapiens_hsa049720.88752970
79Prostate cancer_Homo sapiens_hsa052150.87339971
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85864391
81Pancreatic cancer_Homo sapiens_hsa052120.85421214
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.85279247
83Insulin signaling pathway_Homo sapiens_hsa049100.85082366
84Antigen processing and presentation_Homo sapiens_hsa046120.84688250
85Proteoglycans in cancer_Homo sapiens_hsa052050.84235632
86Acute myeloid leukemia_Homo sapiens_hsa052210.83860762
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82718037
88T cell receptor signaling pathway_Homo sapiens_hsa046600.82325132
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81989673
90Hematopoietic cell lineage_Homo sapiens_hsa046400.81836528
91Thyroid hormone synthesis_Homo sapiens_hsa049180.80337269
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79881451
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78772263
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78614140
95Choline metabolism in cancer_Homo sapiens_hsa052310.78312027
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77618790
97MAPK signaling pathway_Homo sapiens_hsa040100.77046271
98Primary immunodeficiency_Homo sapiens_hsa053400.77013029
99Calcium signaling pathway_Homo sapiens_hsa040200.76667820
100Prolactin signaling pathway_Homo sapiens_hsa049170.76294487
101Gap junction_Homo sapiens_hsa045400.76238116
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76044787
103Colorectal cancer_Homo sapiens_hsa052100.75600307
104Bladder cancer_Homo sapiens_hsa052190.75210508
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.74083876
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73815370
107Bile secretion_Homo sapiens_hsa049760.73143317
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72473322
109Apoptosis_Homo sapiens_hsa042100.72232874
110Toxoplasmosis_Homo sapiens_hsa051450.71879611
111Dilated cardiomyopathy_Homo sapiens_hsa054140.71527634
112Endocytosis_Homo sapiens_hsa041440.71192983
113Renal cell carcinoma_Homo sapiens_hsa052110.70509184
114Glucagon signaling pathway_Homo sapiens_hsa049220.70205676
115ABC transporters_Homo sapiens_hsa020100.69984831
116Small cell lung cancer_Homo sapiens_hsa052220.69877461
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68883842
118HTLV-I infection_Homo sapiens_hsa051660.68294947
119Focal adhesion_Homo sapiens_hsa045100.67364151
120Melanogenesis_Homo sapiens_hsa049160.66936020
121Rap1 signaling pathway_Homo sapiens_hsa040150.66593285
122Inositol phosphate metabolism_Homo sapiens_hsa005620.66259737
123HIF-1 signaling pathway_Homo sapiens_hsa040660.65829212
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65702797
125AMPK signaling pathway_Homo sapiens_hsa041520.62729501
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62228594
127Amoebiasis_Homo sapiens_hsa051460.61802250
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.61040414
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.60795532
130Pertussis_Homo sapiens_hsa051330.59078281
131Tuberculosis_Homo sapiens_hsa051520.58555397
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.58384524
133Leishmaniasis_Homo sapiens_hsa051400.58060168
134FoxO signaling pathway_Homo sapiens_hsa040680.58014740
135Axon guidance_Homo sapiens_hsa043600.56410521
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.55463581
137Fatty acid biosynthesis_Homo sapiens_hsa000610.53790479
138Malaria_Homo sapiens_hsa051440.51777746
139Legionellosis_Homo sapiens_hsa051340.49273971
140Epstein-Barr virus infection_Homo sapiens_hsa051690.49198325
141Lysosome_Homo sapiens_hsa041420.47738049

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