STX17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein prenylation (GO:0018342)7.43527209
2prenylation (GO:0097354)7.43527209
3positive regulation of mitotic sister chromatid separation (GO:1901970)6.29707634
4positive regulation of mitotic metaphase/anaphase transition (GO:0045842)6.29707634
5positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)6.29707634
6L-phenylalanine catabolic process (GO:0006559)5.97057493
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.97057493
8fucose catabolic process (GO:0019317)5.43728932
9L-fucose metabolic process (GO:0042354)5.43728932
10L-fucose catabolic process (GO:0042355)5.43728932
11L-phenylalanine metabolic process (GO:0006558)5.43266992
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.43266992
13aromatic amino acid family catabolic process (GO:0009074)5.08219080
14sulfur amino acid catabolic process (GO:0000098)4.95456236
15complement activation, alternative pathway (GO:0006957)4.87210553
16negative regulation of Ras GTPase activity (GO:0034261)4.83063548
17transcytosis (GO:0045056)4.75055564
18preassembly of GPI anchor in ER membrane (GO:0016254)4.71619766
19short-chain fatty acid metabolic process (GO:0046459)4.50969797
20indole-containing compound catabolic process (GO:0042436)4.43743984
21indolalkylamine catabolic process (GO:0046218)4.43743984
22tryptophan catabolic process (GO:0006569)4.43743984
23alpha-linolenic acid metabolic process (GO:0036109)4.41198630
24cysteine metabolic process (GO:0006534)4.30763833
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.28450578
26cellular ketone body metabolic process (GO:0046950)4.22743428
27kynurenine metabolic process (GO:0070189)4.20431316
28tryptophan metabolic process (GO:0006568)4.15536788
29bile acid biosynthetic process (GO:0006699)4.06474815
30homocysteine metabolic process (GO:0050667)4.04622121
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.03897647
32ethanol oxidation (GO:0006069)4.02859270
33negative regulation of T cell receptor signaling pathway (GO:0050860)4.00562343
34detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.00313664
35regulation of protein activation cascade (GO:2000257)3.98385354
36lysine metabolic process (GO:0006553)3.92527684
37lysine catabolic process (GO:0006554)3.92527684
38regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.91168981
39urea cycle (GO:0000050)3.85906866
40urea metabolic process (GO:0019627)3.85906866
41eosinophil chemotaxis (GO:0048245)3.85871825
42bile acid metabolic process (GO:0008206)3.85066799
43fatty acid beta-oxidation (GO:0006635)3.82434136
44regulation of complement activation (GO:0030449)3.81937846
45gap junction assembly (GO:0016264)3.78654082
46regulation of triglyceride catabolic process (GO:0010896)3.73146069
47regulation of sister chromatid cohesion (GO:0007063)3.70934665
48negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.70245508
49amino-acid betaine metabolic process (GO:0006577)3.68886797
50fatty acid oxidation (GO:0019395)3.64162337
51protein carboxylation (GO:0018214)3.62571850
52peptidyl-glutamic acid carboxylation (GO:0017187)3.62571850
53DNA deamination (GO:0045006)3.61931149
54aromatic amino acid family metabolic process (GO:0009072)3.61576117
55regulation of T cell receptor signaling pathway (GO:0050856)3.60192231
56tyrosine metabolic process (GO:0006570)3.59235481
57ketone body metabolic process (GO:1902224)3.59077774
58fatty acid catabolic process (GO:0009062)3.58396606
59glyoxylate metabolic process (GO:0046487)3.57606429
60lipid oxidation (GO:0034440)3.55685995
61monocarboxylic acid catabolic process (GO:0072329)3.52016216
62eosinophil migration (GO:0072677)3.46762775
63bile acid and bile salt transport (GO:0015721)3.45572104
64acetyl-CoA metabolic process (GO:0006084)3.42466618
65nitrogen cycle metabolic process (GO:0071941)3.41825727
66early endosome to late endosome transport (GO:0045022)3.41798950
67purine nucleotide transport (GO:0015865)3.41463335
68vesicle fusion (GO:0006906)3.40586812
69indolalkylamine metabolic process (GO:0006586)3.39490641
70acylglycerol homeostasis (GO:0055090)3.38556852
71triglyceride homeostasis (GO:0070328)3.38556852
72cellular glucuronidation (GO:0052695)3.35940041
73interkinetic nuclear migration (GO:0022027)3.35309648
74detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.34955797
75amine catabolic process (GO:0009310)3.34180369
76cellular biogenic amine catabolic process (GO:0042402)3.34180369
77drug transmembrane transport (GO:0006855)3.33792589
78high-density lipoprotein particle remodeling (GO:0034375)3.33445247
79ethanol metabolic process (GO:0006067)3.32696170
80GPI anchor biosynthetic process (GO:0006506)3.32113281
81coenzyme catabolic process (GO:0009109)3.31701610
82regulation of fibrinolysis (GO:0051917)3.31419700
83purine ribonucleotide transport (GO:0015868)3.30436247
84positive regulation of chromosome segregation (GO:0051984)3.29683272
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28500718
86negative regulation of lipase activity (GO:0060192)3.28361126
87protein K11-linked deubiquitination (GO:0035871)3.25584965
88GPI anchor metabolic process (GO:0006505)3.25165158
89serine family amino acid catabolic process (GO:0009071)3.21748985
90alpha-amino acid catabolic process (GO:1901606)3.21087530
91benzene-containing compound metabolic process (GO:0042537)3.20363165
92behavioral response to nicotine (GO:0035095)3.20197968
93negative regulation of fibrinolysis (GO:0051918)3.17637952
94acrosome assembly (GO:0001675)3.17526987
95plasma lipoprotein particle clearance (GO:0034381)3.15919367
96epoxygenase P450 pathway (GO:0019373)3.14432962
97phospholipid homeostasis (GO:0055091)3.12695452
98proteasome assembly (GO:0043248)3.12427511
99positive regulation of lipid catabolic process (GO:0050996)3.04563023
100carboxylic acid catabolic process (GO:0046395)3.04536016
101organic acid catabolic process (GO:0016054)3.04536016
102branch elongation of an epithelium (GO:0060602)3.04140071
103biotin metabolic process (GO:0006768)3.03161148
104positive regulation of calcium ion import (GO:0090280)3.03130351
105cellular amino acid catabolic process (GO:0009063)3.02608792
106histone H3-K4 trimethylation (GO:0080182)2.99706891
107macromolecular complex remodeling (GO:0034367)2.98863412
108plasma lipoprotein particle remodeling (GO:0034369)2.98863412
109protein-lipid complex remodeling (GO:0034368)2.98863412
110positive regulation of fatty acid beta-oxidation (GO:0032000)2.98693997
111regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.98038949
112regulation of mononuclear cell migration (GO:0071675)2.97969871
113regulation of sequestering of triglyceride (GO:0010889)2.96567585
114aspartate family amino acid catabolic process (GO:0009068)2.96357764
115fatty acid transmembrane transport (GO:1902001)2.96288643
116carnitine metabolic process (GO:0009437)2.95812903
117reverse cholesterol transport (GO:0043691)2.95486976
118cellular modified amino acid catabolic process (GO:0042219)2.94680838
119piRNA metabolic process (GO:0034587)2.93879792
120adenine nucleotide transport (GO:0051503)2.92902309
121positive regulation of glycoprotein biosynthetic process (GO:0010560)2.90704676
122DNA integration (GO:0015074)2.90068957
123double-strand break repair via nonhomologous end joining (GO:0006303)2.88294750
124non-recombinational repair (GO:0000726)2.88294750
125oxidative demethylation (GO:0070989)2.87642560
126glutamate metabolic process (GO:0006536)2.87588833
127DNA demethylation (GO:0080111)2.87234436
128regulation of cholesterol metabolic process (GO:0090181)2.87189888
129cholesterol efflux (GO:0033344)2.86689945
130synapsis (GO:0007129)2.86630937
131C-terminal protein lipidation (GO:0006501)2.85832179
132histone mRNA catabolic process (GO:0071044)2.83609769
133dopamine transport (GO:0015872)2.82497943
134opsonization (GO:0008228)2.81788884
135cofactor catabolic process (GO:0051187)2.81186278
136cholesterol homeostasis (GO:0042632)2.79013811
137complement activation (GO:0006956)2.78237748
138male meiosis (GO:0007140)2.77260835
139sterol homeostasis (GO:0055092)2.76696057
140very long-chain fatty acid metabolic process (GO:0000038)2.76444022
1412-oxoglutarate metabolic process (GO:0006103)2.75197854
142regulation of protein glycosylation (GO:0060049)2.73751389
143uronic acid metabolic process (GO:0006063)2.71951930
144glucuronate metabolic process (GO:0019585)2.71951930
145fibrinolysis (GO:0042730)2.69920566
146pyrimidine nucleoside catabolic process (GO:0046135)2.69152264
147protein import into peroxisome matrix (GO:0016558)2.68574305
148double-strand break repair via homologous recombination (GO:0000724)2.65153141
149adenosine metabolic process (GO:0046085)2.64658361
150recombinational repair (GO:0000725)2.61759132
151C-terminal protein amino acid modification (GO:0018410)2.59771731
152respiratory chain complex IV assembly (GO:0008535)2.55906255
153branched-chain amino acid catabolic process (GO:0009083)2.55671707
154protein targeting to vacuole (GO:0006623)2.55147732
155protein targeting to lysosome (GO:0006622)2.55147732
156establishment of protein localization to vacuole (GO:0072666)2.55147732
157positive regulation of glycolytic process (GO:0045821)2.51060431
158regulation of hexokinase activity (GO:1903299)2.50851518
159regulation of glucokinase activity (GO:0033131)2.50851518
160somite rostral/caudal axis specification (GO:0032525)2.50743802
161regulation of establishment of cell polarity (GO:2000114)2.48908883
162signal peptide processing (GO:0006465)2.44906497
163S-adenosylmethionine metabolic process (GO:0046500)2.44439780
164organ growth (GO:0035265)2.42213981
165reciprocal meiotic recombination (GO:0007131)2.39444649
166reciprocal DNA recombination (GO:0035825)2.39444649
167xenobiotic catabolic process (GO:0042178)2.39443922
168establishment of protein localization to Golgi (GO:0072600)2.38991018
169male meiosis I (GO:0007141)2.35196626
170hepatocyte apoptotic process (GO:0097284)2.34565697
171prostate gland growth (GO:0060736)2.34349436
172DNA dealkylation (GO:0035510)2.31634614
173detection of chemical stimulus involved in sensory perception (GO:0050907)2.31390682
174regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.30561819
175positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.30561819
176positive regulation of granulocyte differentiation (GO:0030854)2.28235051
177regulation of B cell receptor signaling pathway (GO:0050855)2.28123519
178mannosylation (GO:0097502)2.26708591
179regulation of memory T cell differentiation (GO:0043380)2.25696330
180cullin deneddylation (GO:0010388)2.25012387
181regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.24933667
182positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.24933667
183kidney morphogenesis (GO:0060993)2.24751366
184glycolipid biosynthetic process (GO:0009247)2.24695745
185protein targeting to Golgi (GO:0000042)2.24497288
186centriole replication (GO:0007099)2.24202918
187protein localization to lysosome (GO:0061462)2.24103093
188protein localization to vacuole (GO:0072665)2.24103093
189positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.23673562
190regulation of meiosis I (GO:0060631)2.22494196
191negative regulation of alpha-beta T cell activation (GO:0046636)2.21577987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.30193337
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.53411411
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.01117820
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.91965964
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.77965148
6VDR_22108803_ChIP-Seq_LS180_Human3.75490758
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.72343190
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.71671438
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.84904760
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.76548641
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.53314476
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.49140275
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.38834387
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34361513
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.27082468
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22412124
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21886863
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.20732183
19FUS_26573619_Chip-Seq_HEK293_Human2.18690621
20ZNF274_21170338_ChIP-Seq_K562_Hela2.11956700
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.06426536
22IGF1R_20145208_ChIP-Seq_DFB_Human2.04381156
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03161861
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99158227
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96095904
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86743477
27P300_19829295_ChIP-Seq_ESCs_Human1.85332507
28ER_23166858_ChIP-Seq_MCF-7_Human1.84283035
29EWS_26573619_Chip-Seq_HEK293_Human1.83985955
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81768067
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.81504165
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72778745
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66814169
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62733235
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59420634
36ELK1_19687146_ChIP-ChIP_HELA_Human1.58167830
37* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53970130
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52589303
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.51985417
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51654320
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.50630998
42* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50212366
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47471171
44VDR_23849224_ChIP-Seq_CD4+_Human1.47120088
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45869722
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42492442
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42492442
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37205655
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35858437
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35590042
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34610400
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.34570033
53HTT_18923047_ChIP-ChIP_STHdh_Human1.32622114
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32479062
55GATA1_22025678_ChIP-Seq_K562_Human1.32300973
56SMAD4_21799915_ChIP-Seq_A2780_Human1.31521280
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31485593
58SOX2_19829295_ChIP-Seq_ESCs_Human1.30040952
59NANOG_19829295_ChIP-Seq_ESCs_Human1.30040952
60TAF15_26573619_Chip-Seq_HEK293_Human1.26485713
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26309278
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.25492951
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25492951
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24494748
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24039038
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24039038
67AR_25329375_ChIP-Seq_VCAP_Human1.22661476
68TCF4_22108803_ChIP-Seq_LS180_Human1.22312889
69* TCF4_23295773_ChIP-Seq_U87_Human1.21462804
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21312382
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.19680066
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.19396888
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18494312
74* SRF_21415370_ChIP-Seq_HL-1_Mouse1.16864716
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.16073946
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15067772
77TP53_22573176_ChIP-Seq_HFKS_Human1.14856609
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14348424
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11534468
80* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11219472
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10153616
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09537545
83GATA3_26560356_Chip-Seq_TH1_Human1.09381597
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09158337
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08539708
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.08336036
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08310460
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.07546808
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.07537185
90GATA1_19941826_ChIP-Seq_K562_Human1.07435534
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06530628
92TP53_16413492_ChIP-PET_HCT116_Human1.06493212
93AR_20517297_ChIP-Seq_VCAP_Human1.05960051
94P300_18555785_Chip-Seq_ESCs_Mouse1.04939080
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04024288
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.03780836
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03079463
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03005959
99RUNX_20019798_ChIP-Seq_JUKART_Human1.02768037
100IRF1_19129219_ChIP-ChIP_H3396_Human1.02586483
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02318917
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02124274
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.01192273
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00197138
105BCAT_22108803_ChIP-Seq_LS180_Human0.98971780
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98110701
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.95897640
108* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95607054
109CRX_20693478_ChIP-Seq_RETINA_Mouse0.95155882
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94914601
111GATA2_19941826_ChIP-Seq_K562_Human0.93723455
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93113614
113KDM2B_26808549_Chip-Seq_REH_Human0.93086443
114ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91184872
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90884464
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89937574
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.89538783
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.89395911
119AR_21572438_ChIP-Seq_LNCaP_Human0.88317272
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88281191
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88114191
122HNF4A_19822575_ChIP-Seq_HepG2_Human0.87846082
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86933840
124VDR_24787735_ChIP-Seq_THP-1_Human0.86885708
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85789558
126STAT1_17558387_ChIP-Seq_HELA_Human0.85384874
127GATA4_25053715_ChIP-Seq_YYC3_Human0.85267163
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84930493
129KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84419975
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84301740
131GBX2_23144817_ChIP-Seq_PC3_Human0.83339562
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.83147150
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82531397
134CLOCK_20551151_ChIP-Seq_293T_Human0.82490182
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82367358
136OCT4_18555785_Chip-Seq_ESCs_Mouse0.81643266
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.81148231
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.80983347
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80909402
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.80748488
141JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80688810
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.80563733
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.80563733
144P53_22387025_ChIP-Seq_ESCs_Mouse0.80132362
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.80130794
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79910830
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79843786
148CBP_20019798_ChIP-Seq_JUKART_Human0.79843786
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79627326
150* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78853373
151CDX2_22108803_ChIP-Seq_LS180_Human0.78621794
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.77939238
153SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77937658
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.77133661
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76832185
156FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76034139
157STAT3_23295773_ChIP-Seq_U87_Human0.75530532
158CMYC_18555785_Chip-Seq_ESCs_Mouse0.75308702
159SMAD1_18555785_Chip-Seq_ESCs_Mouse0.74846137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.26795454
2MP0005360_urolithiasis5.71623139
3MP0005085_abnormal_gallbladder_physiolo5.12000908
4MP0005365_abnormal_bile_salt4.90100818
5MP0000569_abnormal_digit_pigmentation4.70744668
6MP0003252_abnormal_bile_duct4.51040878
7MP0008875_abnormal_xenobiotic_pharmacok3.55032233
8MP0010329_abnormal_lipoprotein_level2.78206965
9MP0003806_abnormal_nucleotide_metabolis2.38376357
10MP0000566_synostosis2.36533216
11MP0005075_abnormal_melanosome_morpholog2.29140157
12MP0010678_abnormal_skin_adnexa2.24834480
13MP0006082_CNS_inflammation2.21433656
14MP0001666_abnormal_nutrient_absorption2.20601914
15MP0006054_spinal_hemorrhage2.20297021
16MP0005083_abnormal_biliary_tract2.14710378
17MP0003195_calcinosis2.12088404
18MP0009840_abnormal_foam_cell2.12032596
19MP0005332_abnormal_amino_acid2.10398250
20MP0008058_abnormal_DNA_repair2.08832425
21MP0008995_early_reproductive_senescence2.00260583
22MP0001835_abnormal_antigen_presentation1.98005361
23MP0006072_abnormal_retinal_apoptosis1.97581383
24MP0008877_abnormal_DNA_methylation1.94635202
25MP0003646_muscle_fatigue1.93883943
26MP0003300_gastrointestinal_ulcer1.93608728
27MP0003656_abnormal_erythrocyte_physiolo1.91463335
28MP0002837_dystrophic_cardiac_calcinosis1.89408796
29MP0003303_peritoneal_inflammation1.88339816
30MP0008057_abnormal_DNA_replication1.86011610
31MP0002118_abnormal_lipid_homeostasis1.82635218
32MP0004130_abnormal_muscle_cell1.80735510
33MP0000372_irregular_coat_pigmentation1.76857352
34MP0000609_abnormal_liver_physiology1.76472336
35MP0005253_abnormal_eye_physiology1.75767308
36MP0002928_abnormal_bile_duct1.71147163
37MP0004036_abnormal_muscle_relaxation1.69594773
38MP0002163_abnormal_gland_morphology1.68649524
39MP0001661_extended_life_span1.62948434
40MP0001764_abnormal_homeostasis1.57278453
41MP0001919_abnormal_reproductive_system1.52412477
42MP0005671_abnormal_response_to1.51015736
43MP0005319_abnormal_enzyme/_coenzyme1.46089747
44MP0002751_abnormal_autonomic_nervous1.42330622
45MP0005379_endocrine/exocrine_gland_phen1.41577475
46MP0005584_abnormal_enzyme/coenzyme_acti1.40311513
47MP0005174_abnormal_tail_pigmentation1.38522861
48MP0005389_reproductive_system_phenotype1.38479274
49MP0009764_decreased_sensitivity_to1.38259929
50MP0003690_abnormal_glial_cell1.36620894
51MP0003868_abnormal_feces_composition1.36290566
52MP0005410_abnormal_fertilization1.35048140
53MP0006292_abnormal_olfactory_placode1.33519763
54MP0005666_abnormal_adipose_tissue1.32156778
55MP0003763_abnormal_thymus_physiology1.31761650
56MP0009384_cardiac_valve_regurgitation1.31544477
57MP0008004_abnormal_stomach_pH1.29266683
58MP0005647_abnormal_sex_gland1.27378399
59MP0005670_abnormal_white_adipose1.26261351
60MP0002102_abnormal_ear_morphology1.24615470
61MP0003724_increased_susceptibility_to1.23346022
62MP0001800_abnormal_humoral_immune1.21867629
63MP0005397_hematopoietic_system_phenotyp1.21103197
64MP0001545_abnormal_hematopoietic_system1.21103197
65MP0005551_abnormal_eye_electrophysiolog1.19729475
66MP0000751_myopathy1.19470173
67MP0002009_preneoplasia1.18208922
68MP0000013_abnormal_adipose_tissue1.18178593
69MP0008872_abnormal_physiological_respon1.17812847
70MP0004215_abnormal_myocardial_fiber1.17804226
71MP0005084_abnormal_gallbladder_morpholo1.17763823
72MP0005058_abnormal_lysosome_morphology1.17678426
73MP0009697_abnormal_copulation1.12780871
74MP0005646_abnormal_pituitary_gland1.10992111
75MP0002168_other_aberrant_phenotype1.10884899
76MP0005451_abnormal_body_composition1.10171886
77MP0009643_abnormal_urine_homeostasis1.09372138
78MP0004147_increased_porphyrin_level1.09184655
79MP0000462_abnormal_digestive_system1.07174251
80MP0002938_white_spotting1.06231727
81MP0010368_abnormal_lymphatic_system1.05564978
82MP0003786_premature_aging1.05440829
83MP0005645_abnormal_hypothalamus_physiol1.05315098
84MP0003718_maternal_effect1.03540651
85MP0003943_abnormal_hepatobiliary_system1.02017876
86MP0000579_abnormal_nail_morphology1.01195366
87MP0001664_abnormal_digestion1.00458019
88MP0004019_abnormal_vitamin_homeostasis1.00355464
89MP0000427_abnormal_hair_cycle0.98002732
90MP0000647_abnormal_sebaceous_gland0.97869710
91MP0001929_abnormal_gametogenesis0.94605610
92MP0005334_abnormal_fat_pad0.93918744
93MP0000598_abnormal_liver_morphology0.93872436
94MP0002254_reproductive_system_inflammat0.93576278
95MP0002693_abnormal_pancreas_physiology0.92692335
96MP0003011_delayed_dark_adaptation0.92231421
97MP0003890_abnormal_embryonic-extraembry0.92104216
98MP0008469_abnormal_protein_level0.90066632
99MP0002138_abnormal_hepatobiliary_system0.89705835
100MP0005220_abnormal_exocrine_pancreas0.89010672
101MP0006036_abnormal_mitochondrial_physio0.88657075
102MP0005503_abnormal_tendon_morphology0.88400660
103MP0004185_abnormal_adipocyte_glucose0.88249834
104MP0001984_abnormal_olfaction0.87776291
105MP0002452_abnormal_antigen_presenting0.87581131
106MP0004233_abnormal_muscle_weight0.87051837
107MP0005000_abnormal_immune_tolerance0.86996046
108MP0005330_cardiomyopathy0.85791097
109MP0000920_abnormal_myelination0.85308854
110MP0005636_abnormal_mineral_homeostasis0.84323293
111MP0004381_abnormal_hair_follicle0.84193355
112MP0002166_altered_tumor_susceptibility0.83961729
113MP0004087_abnormal_muscle_fiber0.83148687
114MP0002160_abnormal_reproductive_system0.81844547
115MP0002095_abnormal_skin_pigmentation0.81407069
116MP0005266_abnormal_metabolism0.81144186
117MP0000015_abnormal_ear_pigmentation0.80399604
118MP0005395_other_phenotype0.79705055
119MP0003186_abnormal_redox_activity0.79382502
120MP0010630_abnormal_cardiac_muscle0.79379664
121MP0009763_increased_sensitivity_to0.79316969
122MP0000689_abnormal_spleen_morphology0.78019438
123MP0002148_abnormal_hypersensitivity_rea0.77402648
124MP0008775_abnormal_heart_ventricle0.77268438
125MP0008438_abnormal_cutaneous_collagen0.76686573
126MP0002876_abnormal_thyroid_physiology0.76594379
127MP0005375_adipose_tissue_phenotype0.76536108
128MP0002210_abnormal_sex_determination0.76415730
129MP0002723_abnormal_immune_serum0.75328676
130MP0002971_abnormal_brown_adipose0.75306908
131MP0000749_muscle_degeneration0.74330557
132MP0002019_abnormal_tumor_incidence0.73072268
133MP0009785_altered_susceptibility_to0.72906676
134MP0010094_abnormal_chromosome_stability0.72784776
135MP0000747_muscle_weakness0.72483445
136MP0002006_tumorigenesis0.72196697
137MP0001663_abnormal_digestive_system0.71582424
138MP0005310_abnormal_salivary_gland0.70638098
139MP0006138_congestive_heart_failure0.70632936
140MP0001119_abnormal_female_reproductive0.70598422
141MP0002078_abnormal_glucose_homeostasis0.70413495
142MP0003191_abnormal_cellular_cholesterol0.69913112
143MP0003705_abnormal_hypodermis_morpholog0.69910274
144MP0004484_altered_response_of0.69870118
145MP0002295_abnormal_pulmonary_circulatio0.69373959
146MP0000685_abnormal_immune_system0.69268643
147MP0010352_gastrointestinal_tract_polyps0.68859715
148MP0003045_fibrosis0.67708144
149MP0004272_abnormal_basement_membrane0.67208120
150MP0000767_abnormal_smooth_muscle0.67075494
151MP0009642_abnormal_blood_homeostasis0.65303319
152MP0000383_abnormal_hair_follicle0.64651425
153MP0000538_abnormal_urinary_bladder0.64280988
154MP0001879_abnormal_lymphatic_vessel0.63791937
155MP0010155_abnormal_intestine_physiology0.63241724
156MP0005620_abnormal_muscle_contractility0.63052095
157MP0003221_abnormal_cardiomyocyte_apopto0.62737065
158MP0000467_abnormal_esophagus_morphology0.62190607
159MP0004782_abnormal_surfactant_physiolog0.61676777
160MP0004043_abnormal_pH_regulation0.59556304
161MP0005376_homeostasis/metabolism_phenot0.58760667
162MP0000604_amyloidosis0.58742107
163MP0005464_abnormal_platelet_physiology0.58123765
164MP0002106_abnormal_muscle_physiology0.57170953
165MP0000230_abnormal_systemic_arterial0.56152920
166MP0005369_muscle_phenotype0.55203017
167MP0005595_abnormal_vascular_smooth0.54958921

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.97005854
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.93598702
3Hyperlipoproteinemia (HP:0010980)4.72019228
4Intrahepatic cholestasis (HP:0001406)4.58616393
5Xanthomatosis (HP:0000991)4.26964940
6Abnormality of glycine metabolism (HP:0010895)4.12598160
7Abnormality of serine family amino acid metabolism (HP:0010894)4.12598160
8Prolonged partial thromboplastin time (HP:0003645)4.04526653
9Hyperglycinuria (HP:0003108)3.92676548
10Hyperglycinemia (HP:0002154)3.84939214
11Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.74230883
12Ketosis (HP:0001946)3.52524574
13Neonatal hypoglycemia (HP:0001998)3.48915594
14Dicarboxylic aciduria (HP:0003215)3.46298319
15Abnormality of dicarboxylic acid metabolism (HP:0010995)3.46298319
16Abnormality of fatty-acid metabolism (HP:0004359)3.42725902
17Hypobetalipoproteinemia (HP:0003563)3.40066232
18Complement deficiency (HP:0004431)3.39115832
19Hypoglycemic coma (HP:0001325)3.35065557
20Hyperammonemia (HP:0001987)3.34988427
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.33374966
22Hypoalphalipoproteinemia (HP:0003233)3.32544675
23Duplicated collecting system (HP:0000081)3.31639357
24Exercise-induced myalgia (HP:0003738)3.24093341
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.20554481
26Large for gestational age (HP:0001520)3.18370620
27Hypothermia (HP:0002045)3.15548357
28Hypolipoproteinemia (HP:0010981)3.14328402
29Abnormality of monocarboxylic acid metabolism (HP:0010996)3.11623480
30Abnormality of the renal collecting system (HP:0004742)3.09133275
31Hypercholesterolemia (HP:0003124)2.97999435
32Joint hemorrhage (HP:0005261)2.93661918
33Abnormality of the renal cortex (HP:0011035)2.91307264
34Enlarged kidneys (HP:0000105)2.85902727
35Abnormality of proline metabolism (HP:0010907)2.85069676
36Hydroxyprolinuria (HP:0003080)2.85069676
37Aplasia/Hypoplasia of the fovea (HP:0008060)2.78625290
38Hypoplasia of the fovea (HP:0007750)2.78625290
39Myocardial infarction (HP:0001658)2.78132238
40Abnormality of serum amino acid levels (HP:0003112)2.75425913
41Thyroiditis (HP:0100646)2.75275295
42Epidermoid cyst (HP:0200040)2.74632811
43Ketoacidosis (HP:0001993)2.72335430
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.69550030
45Hepatoblastoma (HP:0002884)2.69532798
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.68033315
47Fat malabsorption (HP:0002630)2.68015854
48Neoplasm of the adrenal cortex (HP:0100641)2.63692280
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.62689818
50Abnormality of methionine metabolism (HP:0010901)2.61129067
51Muscle fiber splitting (HP:0003555)2.60998572
52Conjugated hyperbilirubinemia (HP:0002908)2.58721393
53Abnormality of macular pigmentation (HP:0008002)2.58369592
54Ileus (HP:0002595)2.52473023
55Delayed CNS myelination (HP:0002188)2.48554702
56Congenital stationary night blindness (HP:0007642)2.48534935
57Fair hair (HP:0002286)2.48212155
58Abnormality of the common coagulation pathway (HP:0010990)2.47315670
59Abnormal glucose tolerance (HP:0001952)2.46182080
60Acute lymphatic leukemia (HP:0006721)2.45967177
61Widely spaced teeth (HP:0000687)2.43684643
62Hyperbilirubinemia (HP:0002904)2.43390446
63Acanthocytosis (HP:0001927)2.43313699
64Abnormality of the fovea (HP:0000493)2.41468364
65Pancreatic cysts (HP:0001737)2.39375961
66Stomatitis (HP:0010280)2.38893118
67Methylmalonic aciduria (HP:0012120)2.37763369
68Abnormality of complement system (HP:0005339)2.36860951
69Methylmalonic acidemia (HP:0002912)2.35674740
70Clubbing of toes (HP:0100760)2.31300125
71Broad metatarsal (HP:0001783)2.30483097
72Nephronophthisis (HP:0000090)2.29769984
73Hyperglycemia (HP:0003074)2.29600802
74Abnormal pancreas size (HP:0012094)2.28605214
75Neurofibrillary tangles (HP:0002185)2.27031338
76Poikilocytosis (HP:0004447)2.26432167
77Adactyly (HP:0009776)2.25147371
78Long foot (HP:0001833)2.25032517
79Oligodactyly (hands) (HP:0001180)2.24153172
80Volvulus (HP:0002580)2.23339622
81Metabolic acidosis (HP:0001942)2.22846875
82Progressive macrocephaly (HP:0004481)2.22157862
83Autoimmune hemolytic anemia (HP:0001890)2.22028514
84Diastasis recti (HP:0001540)2.21233165
85Distal lower limb muscle weakness (HP:0009053)2.21116692
86Abnormality of the renal medulla (HP:0100957)2.20292125
87Anhidrosis (HP:0000970)2.14570027
88Gingival bleeding (HP:0000225)2.13839859
89Renal cortical cysts (HP:0000803)2.13838899
90Mitral stenosis (HP:0001718)2.11925631
91Chronic hepatic failure (HP:0100626)2.11833669
92Cholelithiasis (HP:0001081)2.11688387
93Stomach cancer (HP:0012126)2.08899119
94Abnormal gallbladder morphology (HP:0012437)2.08762192
95Hypoglycemic seizures (HP:0002173)2.08494257
96Medial flaring of the eyebrow (HP:0010747)2.08190220
97Acute necrotizing encephalopathy (HP:0006965)2.07625557
98Mitochondrial inheritance (HP:0001427)2.07226349
99Abnormality of purine metabolism (HP:0004352)2.06231809
100Abnormality of vitamin B metabolism (HP:0004340)2.05393118
101Intestinal atresia (HP:0011100)2.03253188
102Eosinophilia (HP:0001880)2.03181078
103Abnormality of midbrain morphology (HP:0002418)2.03137170
104Molar tooth sign on MRI (HP:0002419)2.03137170
105Abnormality of eosinophils (HP:0001879)2.02599716
106Abnormality of the intrinsic pathway (HP:0010989)2.02162481
107Increased CSF lactate (HP:0002490)1.98980158
108Hematochezia (HP:0002573)1.97324871
109Skin nodule (HP:0200036)1.97139659
110Spastic paraparesis (HP:0002313)1.96416541
111Attenuation of retinal blood vessels (HP:0007843)1.96390994
112Vascular calcification (HP:0004934)1.94852657
113Bell-shaped thorax (HP:0001591)1.93283343
114Cardiovascular calcification (HP:0011915)1.92739732
115Submucous cleft hard palate (HP:0000176)1.91711741
116Gaze-evoked nystagmus (HP:0000640)1.91374342
117Abnormality of urine glucose concentration (HP:0011016)1.91304195
118Glycosuria (HP:0003076)1.91304195
119Acute encephalopathy (HP:0006846)1.91209884
120Pancreatic fibrosis (HP:0100732)1.91076965
121Congenital, generalized hypertrichosis (HP:0004540)1.90191773
122Dry hair (HP:0011359)1.89765694
123Hyporeflexia of lower limbs (HP:0002600)1.89670321
124Broad-based gait (HP:0002136)1.89396465
125Myoglobinuria (HP:0002913)1.89332296
126Calf muscle hypertrophy (HP:0008981)1.88926812
127Abnormality of T cell number (HP:0011839)1.88764070
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86909100
129Abnormality of alanine metabolism (HP:0010916)1.86909100
130Hyperalaninemia (HP:0003348)1.86909100
131Steatorrhea (HP:0002570)1.86411201
132Polycythemia (HP:0001901)1.85746175
133Tubulointerstitial nephritis (HP:0001970)1.85546607
134Hypoplastic iliac wings (HP:0002866)1.85413164
135Gout (HP:0001997)1.85165887
136True hermaphroditism (HP:0010459)1.84885850
137Mucopolysacchariduria (HP:0008155)1.84366159
138Urinary glycosaminoglycan excretion (HP:0003541)1.84366159
139Hypoplastic nipples (HP:0002557)1.84354571
140Aplasia/Hypoplasia of the macula (HP:0008059)1.83516593
141Decreased central vision (HP:0007663)1.82835971
142Hyperventilation (HP:0002883)1.82126643
143Cerebral hemorrhage (HP:0001342)1.81566910
144Generalized hypopigmentation of hair (HP:0011358)1.81158137
145Lethargy (HP:0001254)1.81149629
146Generalized aminoaciduria (HP:0002909)1.80577065
147Abnormality of B cell number (HP:0010975)1.78572475
148Autoamputation (HP:0001218)1.78401688
149Hemorrhage of the eye (HP:0011885)1.78209174
150Insulin-resistant diabetes mellitus (HP:0000831)1.77242612
151Hypoproteinemia (HP:0003075)1.77124438
152Spontaneous abortion (HP:0005268)1.76434251
153Brushfield spots (HP:0001088)1.75969127
154Abnormality of the distal phalanges of the toes (HP:0010182)1.75862835
155Abnormality of polysaccharide metabolism (HP:0011012)1.75522253
156Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75522253
157Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75522253
158Respiratory distress (HP:0002098)1.75368811
159Abnormality of the vitamin B12 metabolism (HP:0004341)1.75311269
160Pancreatitis (HP:0001733)1.75040682
161Albinism (HP:0001022)1.74444568
162Abnormality of vitamin metabolism (HP:0100508)1.74359465
163Asymmetric septal hypertrophy (HP:0001670)1.73881076
1643-Methylglutaconic aciduria (HP:0003535)1.73758687
165Hepatocellular carcinoma (HP:0001402)1.71376533
166Abolished electroretinogram (ERG) (HP:0000550)1.71339606
167Severe combined immunodeficiency (HP:0004430)1.71201292
168Muscle hypertrophy of the lower extremities (HP:0008968)1.71100874
169Dynein arm defect of respiratory motile cilia (HP:0012255)1.71069955
170Absent/shortened dynein arms (HP:0200106)1.71069955
171IgG deficiency (HP:0004315)1.70249929
172Abnormality of chromosome stability (HP:0003220)1.69667581
173Abnormal rod and cone electroretinograms (HP:0008323)1.67973495
174Abnormal mitochondria in muscle tissue (HP:0008316)1.67031531
175Aplasia/Hypoplasia of the tibia (HP:0005772)1.66728799
176Aplasia/Hypoplasia affecting the retina (HP:0008061)1.66498097
177Severe muscular hypotonia (HP:0006829)1.66137701
178Hepatic necrosis (HP:0002605)1.64977039
179Lactic acidosis (HP:0003128)1.64646365
180Cerebral edema (HP:0002181)1.63992168
181Congenital hepatic fibrosis (HP:0002612)1.62974197
182Palmoplantar hyperkeratosis (HP:0000972)1.62704803
183Neoplasm of the adrenal gland (HP:0100631)1.62622687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.70729677
2NUAK15.37369134
3MKNK13.93798663
4DMPK3.52972874
5PIK3CA3.34617533
6MAP3K72.89807383
7TAOK32.87470433
8MAP4K22.81105644
9PHKG12.34669845
10PHKG22.34669845
11BCKDK2.30702914
12FRK2.26325607
13FGFR22.26186462
14TRIM282.23620668
15TAOK22.23412180
16TAOK12.20305729
17EIF2AK32.15457181
18PDK32.07912803
19PDK42.07912803
20TEC2.01585448
21OBSCN1.99787188
22MST41.90560746
23PRKG21.82362881
24STK391.80889495
25STK38L1.75266450
26PDK21.72870488
27INSRR1.70056543
28SIK11.70039876
29STK161.68032229
30BMPR1B1.65127886
31GRK11.62643229
32NLK1.62425859
33MAP3K31.62285163
34LMTK21.58433054
35PKN11.53769169
36MAPK151.52924990
37JAK31.52344381
38ACVR1B1.49122027
39TTN1.45815477
40ADRBK21.40418740
41PIK3CG1.39638904
42MAP2K31.36563257
43LATS11.34414850
44CAMK1D1.34277985
45CAMK1G1.33240096
46MAPKAPK51.22571154
47IRAK11.22548004
48PRKAA21.20530308
49FGFR41.14387134
50NEK61.13560816
51TYK21.13370474
52TIE11.12610584
53MYLK1.10767363
54BMPR21.10652244
55TXK1.10300198
56EIF2AK11.08678736
57FGFR31.08617826
58TLK11.08616576
59PDPK11.08278480
60PLK21.05539073
61PDK11.03713307
62ILK1.03648652
63ERBB21.01292433
64AKT31.00776544
65EPHB20.97953843
66JAK10.97910194
67EPHA30.95182012
68ERBB30.94653451
69FER0.92574534
70MAP3K60.92232655
71WNK40.91820977
72MAP3K50.90980122
73IRAK30.86600759
74WNK30.86062611
75ERBB40.84597358
76MAP2K20.82916920
77TBK10.82626235
78MAP2K60.81452884
79PRKCQ0.81070969
80DYRK1B0.78410915
81MAP3K130.78043816
82CAMKK20.77693563
83WNK10.77132420
84EPHB10.77073157
85PAK30.76501209
86CAMK2D0.76422271
87KIT0.75223447
88CASK0.75125679
89ZAK0.75106920
90OXSR10.74235644
91CAMK2G0.72591722
92PRKG10.72474980
93PTK2B0.69171437
94DYRK1A0.68596804
95MAPK130.67895089
96PLK30.67352998
97TRIB30.65438468
98CSK0.65192587
99CCNB10.64244448
100PRKCE0.64088518
101MAP2K40.63820124
102IKBKB0.62540468
103SRPK10.61800301
104MAP3K110.60485834
105PRKAA10.60179659
106RAF10.59038293
107CAMK2B0.58666410
108PLK40.56473891
109PINK10.56354424
110TNIK0.56254671
111ITK0.56004574
112IRAK40.55344061
113BRSK20.55005951
114SYK0.52917164
115MST1R0.52150790
116MAP2K10.51615780
117MAPKAPK30.50977187
118MAPK110.50758822
119NTRK10.50428856
120VRK10.50107447
121BLK0.49875781
122TRPM70.48983161
123PDGFRB0.48815604
124JAK20.48059515
125NEK90.47958401
126PRKACB0.46968205
127ICK0.46298507
128CSNK1A1L0.43839136
129RET0.43103855
130CSNK1G10.42926506
131FLT30.42729008
132MARK30.42012275
133RPS6KA50.41042820
134ERN10.40584991
135PNCK0.39892649
136CSF1R0.39840690
137MAPK120.39211952
138STK30.39099662
139MAP3K20.38086493
140BTK0.37069118
141IKBKE0.36938856
142PBK0.36723879
143PRKACG0.35769988
144PTK60.35133676
145TGFBR10.34899562
146CHEK20.34243438
147ATM0.34036745
148MAP3K10.32269996
149CHUK0.31516130
150WEE10.30273293
151ADRBK10.30097023
152SGK20.29398292
153IGF1R0.29311540
154MARK20.27865566
155CSNK1G30.27679199
156CSNK1G20.27584773
157MAPK40.27547025
158ABL10.27349862
159CAMK2A0.27162024
160CDK60.26289537
161FGR0.26188674

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.25008343
2Fatty acid degradation_Homo sapiens_hsa000713.06909371
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.05329218
4Nitrogen metabolism_Homo sapiens_hsa009102.99445171
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94848296
6Propanoate metabolism_Homo sapiens_hsa006402.94044232
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67839796
8Tryptophan metabolism_Homo sapiens_hsa003802.58861250
9Butanoate metabolism_Homo sapiens_hsa006502.56970583
10Protein export_Homo sapiens_hsa030602.54686238
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52703844
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44720410
13Fatty acid metabolism_Homo sapiens_hsa012122.39996308
14Asthma_Homo sapiens_hsa053102.32836259
15PPAR signaling pathway_Homo sapiens_hsa033202.25867474
16Proteasome_Homo sapiens_hsa030502.23207988
17* SNARE interactions in vesicular transport_Homo sapiens_hsa041302.22063884
18Complement and coagulation cascades_Homo sapiens_hsa046102.15101056
19Histidine metabolism_Homo sapiens_hsa003402.13004404
20Peroxisome_Homo sapiens_hsa041462.10366282
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07542111
22Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05466691
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03541112
24Graft-versus-host disease_Homo sapiens_hsa053322.03374289
25Pyruvate metabolism_Homo sapiens_hsa006202.03041031
26Caffeine metabolism_Homo sapiens_hsa002321.94619433
27Basal transcription factors_Homo sapiens_hsa030221.93685999
28Allograft rejection_Homo sapiens_hsa053301.92801103
29Fatty acid elongation_Homo sapiens_hsa000621.92725485
30Autoimmune thyroid disease_Homo sapiens_hsa053201.91545712
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87899658
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.86977249
33Type I diabetes mellitus_Homo sapiens_hsa049401.82978547
34beta-Alanine metabolism_Homo sapiens_hsa004101.80367985
35Arginine biosynthesis_Homo sapiens_hsa002201.79250263
36Vitamin B6 metabolism_Homo sapiens_hsa007501.78286708
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77071722
38Retinol metabolism_Homo sapiens_hsa008301.73801705
39Chemical carcinogenesis_Homo sapiens_hsa052041.67542083
40Staphylococcus aureus infection_Homo sapiens_hsa051501.64662109
41RNA polymerase_Homo sapiens_hsa030201.62738836
42Homologous recombination_Homo sapiens_hsa034401.58383954
43Sulfur metabolism_Homo sapiens_hsa009201.57871734
44Phototransduction_Homo sapiens_hsa047441.51392777
45Tyrosine metabolism_Homo sapiens_hsa003501.51034449
46Starch and sucrose metabolism_Homo sapiens_hsa005001.48718023
47ABC transporters_Homo sapiens_hsa020101.47323955
48Fanconi anemia pathway_Homo sapiens_hsa034601.47003395
49Non-homologous end-joining_Homo sapiens_hsa034501.46039613
50Regulation of autophagy_Homo sapiens_hsa041401.36498540
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30691328
52Primary immunodeficiency_Homo sapiens_hsa053401.29979176
53Steroid biosynthesis_Homo sapiens_hsa001001.23238181
54Taste transduction_Homo sapiens_hsa047421.22319056
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20914773
56Bile secretion_Homo sapiens_hsa049761.16762643
57One carbon pool by folate_Homo sapiens_hsa006701.14869848
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14491062
59Selenocompound metabolism_Homo sapiens_hsa004501.12054385
60Carbon metabolism_Homo sapiens_hsa012001.11142396
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09717179
62Oxidative phosphorylation_Homo sapiens_hsa001901.08071321
63Lysine degradation_Homo sapiens_hsa003101.05795026
64Fat digestion and absorption_Homo sapiens_hsa049751.05698561
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03820522
66RNA degradation_Homo sapiens_hsa030181.03269779
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99607211
68Olfactory transduction_Homo sapiens_hsa047400.96799336
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94655759
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92221661
71Fatty acid biosynthesis_Homo sapiens_hsa000610.91009803
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.90164559
73Vitamin digestion and absorption_Homo sapiens_hsa049770.89028786
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88749936
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87130385
76Phenylalanine metabolism_Homo sapiens_hsa003600.86792148
77Arginine and proline metabolism_Homo sapiens_hsa003300.86506148
78Linoleic acid metabolism_Homo sapiens_hsa005910.85278971
79Nucleotide excision repair_Homo sapiens_hsa034200.85244471
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85221965
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.83320741
82Antigen processing and presentation_Homo sapiens_hsa046120.83049243
83Parkinsons disease_Homo sapiens_hsa050120.81686058
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81438656
85Glycerolipid metabolism_Homo sapiens_hsa005610.80768115
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73679955
87Rheumatoid arthritis_Homo sapiens_hsa053230.73248670
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71768489
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.70821170
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70713505
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.65883767
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64982826
93Insulin resistance_Homo sapiens_hsa049310.64036540
94Systemic lupus erythematosus_Homo sapiens_hsa053220.62782729
95Folate biosynthesis_Homo sapiens_hsa007900.61941963
96Hematopoietic cell lineage_Homo sapiens_hsa046400.59916913
97Glucagon signaling pathway_Homo sapiens_hsa049220.56404684
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55916009
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55177471
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52931572
101Purine metabolism_Homo sapiens_hsa002300.51986419
102Glutathione metabolism_Homo sapiens_hsa004800.51898375
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51091310
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.50452766
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47331775
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.46714157
107AMPK signaling pathway_Homo sapiens_hsa041520.46216995
108Ovarian steroidogenesis_Homo sapiens_hsa049130.45316915
109RNA transport_Homo sapiens_hsa030130.42731299
110Viral myocarditis_Homo sapiens_hsa054160.41395413
111Metabolic pathways_Homo sapiens_hsa011000.41260937
112Mismatch repair_Homo sapiens_hsa034300.40656767
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.40080050
114Dorso-ventral axis formation_Homo sapiens_hsa043200.38806555
115Pentose phosphate pathway_Homo sapiens_hsa000300.38774175
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37726767
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.37431030
118Serotonergic synapse_Homo sapiens_hsa047260.36656781
119African trypanosomiasis_Homo sapiens_hsa051430.36008081
120Biosynthesis of amino acids_Homo sapiens_hsa012300.33078955
121Huntingtons disease_Homo sapiens_hsa050160.31102941
122Ether lipid metabolism_Homo sapiens_hsa005650.30465682
123Herpes simplex infection_Homo sapiens_hsa051680.29760590
124Legionellosis_Homo sapiens_hsa051340.28910614
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27638856
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26289775
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.23461246
128Thyroid hormone synthesis_Homo sapiens_hsa049180.23343844
129ECM-receptor interaction_Homo sapiens_hsa045120.22175558
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.20691957
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.20524724
132Amoebiasis_Homo sapiens_hsa051460.19229727
133Insulin signaling pathway_Homo sapiens_hsa049100.18924295
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17141246
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15892747
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15254065
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15108757
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14159096
139Arachidonic acid metabolism_Homo sapiens_hsa005900.11831904
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09279688
141Malaria_Homo sapiens_hsa051440.07127687
142Dilated cardiomyopathy_Homo sapiens_hsa054140.05945602
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.05179576
144Platelet activation_Homo sapiens_hsa046110.04717454
145Circadian rhythm_Homo sapiens_hsa047100.04625204
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04053275
147Protein digestion and absorption_Homo sapiens_hsa049740.03639729
148Pancreatic secretion_Homo sapiens_hsa049720.02996060
149Leishmaniasis_Homo sapiens_hsa051400.02315618

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