STX18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) which is part of a membrane tethering complex that includes other SNAREs and several peripheral membrane proteins, and is involved in vesicular transport between the endoplasmic reticulum (ER) and the Golgi complex. The encoded protein is important for the organization of the smooth, rough, and exit site ER subdomains. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activation of MAPKKK activity (GO:0000185)8.11192784
2purine deoxyribonucleotide catabolic process (GO:0009155)6.93657911
3rRNA transcription (GO:0009303)5.87147280
4leukocyte aggregation (GO:0070486)5.77590798
5nucleoside diphosphate catabolic process (GO:0009134)5.48674006
6positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)5.48530060
7intraciliary transport (GO:0042073)5.06179392
8signal peptide processing (GO:0006465)4.96328922
9deoxyribonucleotide catabolic process (GO:0009264)4.95938253
10purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.92402813
11regulation of cilium movement (GO:0003352)4.68904684
12piRNA metabolic process (GO:0034587)4.59840135
13deoxyribose phosphate catabolic process (GO:0046386)4.54121042
14microtubule depolymerization (GO:0007019)4.52952278
15positive regulation of signal transduction by p53 class mediator (GO:1901798)4.37669581
16immunoglobulin mediated immune response (GO:0016064)4.09722845
17deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.08286147
18chaperone-mediated protein transport (GO:0072321)4.04664896
19meiotic chromosome segregation (GO:0045132)4.00545629
20macroautophagy (GO:0016236)3.95679099
21protein maturation by protein folding (GO:0022417)3.87424190
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.86295448
23NADH dehydrogenase complex assembly (GO:0010257)3.86295448
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86295448
25ER overload response (GO:0006983)3.79993193
26protein complex biogenesis (GO:0070271)3.78618809
27ribonucleoprotein complex disassembly (GO:0032988)3.77681206
28positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.76785050
29SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.76693057
30glucosamine-containing compound catabolic process (GO:1901072)3.73155296
31respiratory chain complex IV assembly (GO:0008535)3.67472451
32guanosine-containing compound biosynthetic process (GO:1901070)3.64105091
33glycoprotein catabolic process (GO:0006516)3.58890897
34proteasome assembly (GO:0043248)3.58608810
35organelle disassembly (GO:1903008)3.58534670
36nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.58024864
37GTP biosynthetic process (GO:0006183)3.56723410
38positive regulation of monocyte chemotaxis (GO:0090026)3.44103226
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.39797328
40autophagic vacuole assembly (GO:0000045)3.39730020
41DNA damage response, detection of DNA damage (GO:0042769)3.34855491
42DNA methylation involved in gamete generation (GO:0043046)3.34353093
43epithelial cilium movement (GO:0003351)3.33834156
44purine deoxyribonucleotide metabolic process (GO:0009151)3.32760669
45cytochrome complex assembly (GO:0017004)3.32474401
46positive regulation of defense response to virus by host (GO:0002230)3.32213735
47cilium movement (GO:0003341)3.31812505
48I-kappaB kinase/NF-kappaB signaling (GO:0007249)3.31790707
49negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.30562293
50sulfate transport (GO:0008272)3.27237176
51ubiquinone biosynthetic process (GO:0006744)3.26876847
52quinone biosynthetic process (GO:1901663)3.26876847
53dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.25172195
54histone H3-K4 trimethylation (GO:0080182)3.25158392
55resolution of meiotic recombination intermediates (GO:0000712)3.24432643
56mannosylation (GO:0097502)3.22403806
57protein polyglutamylation (GO:0018095)3.21579493
58ubiquinone metabolic process (GO:0006743)3.19929326
59mitochondrial respiratory chain complex assembly (GO:0033108)3.19607073
60DNA deamination (GO:0045006)3.17950270
61regulation of cytokine secretion involved in immune response (GO:0002739)3.17113938
62cilium or flagellum-dependent cell motility (GO:0001539)3.13266053
63mitotic metaphase plate congression (GO:0007080)3.10420751
64deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09403201
65cellular protein complex localization (GO:0034629)3.09205788
66tRNA methylation (GO:0030488)3.08786373
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06293935
682-deoxyribonucleotide metabolic process (GO:0009394)3.06178094
69positive regulation of mitochondrial fission (GO:0090141)3.05912500
70establishment of viral latency (GO:0019043)3.04033340
71glycosphingolipid catabolic process (GO:0046479)3.02302350
72nucleoside diphosphate phosphorylation (GO:0006165)3.02207937
73CTP biosynthetic process (GO:0006241)2.99859185
74CTP metabolic process (GO:0046036)2.99859185
75axoneme assembly (GO:0035082)2.99532040
76COPI coating of Golgi vesicle (GO:0048205)2.99467919
77Golgi transport vesicle coating (GO:0048200)2.99467919
78formation of translation preinitiation complex (GO:0001731)2.98866517
79amino sugar catabolic process (GO:0046348)2.97955644
80endothelial cell development (GO:0001885)2.97763379
81regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.96882607
82B cell mediated immunity (GO:0019724)2.95751174
83negative regulation of dendrite development (GO:2000171)2.94752626
84nucleotide transmembrane transport (GO:1901679)2.94693581
85negative regulation of macroautophagy (GO:0016242)2.94536568
86axonemal dynein complex assembly (GO:0070286)2.94292159
87regulation of microtubule-based movement (GO:0060632)2.93583038
88regulation of mast cell activation (GO:0033003)2.93559543
89glycolipid catabolic process (GO:0019377)2.92145011
90UTP biosynthetic process (GO:0006228)2.91043676
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90946708
92virion attachment to host cell (GO:0019062)2.87688171
93adhesion of symbiont to host cell (GO:0044650)2.87688171
94ncRNA catabolic process (GO:0034661)2.87655005
95termination of RNA polymerase III transcription (GO:0006386)2.86641690
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.86641690
97cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.85891789
98regulation of cellular amino acid metabolic process (GO:0006521)2.84392108
99protein deneddylation (GO:0000338)2.84082425
100microtubule polymerization or depolymerization (GO:0031109)2.83674274
101chaperone mediated protein folding requiring cofactor (GO:0051085)2.83077712
102regulation of double-strand break repair (GO:2000779)2.82733246
103UTP metabolic process (GO:0046051)2.82546358
104mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82068210
105amyloid precursor protein catabolic process (GO:0042987)2.81842697
106positive regulation of viral transcription (GO:0050434)2.81061646
107protein targeting to plasma membrane (GO:0072661)2.80751172
108maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.80061793
109mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79790229
110regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.78026181
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77054352
112GDP-mannose metabolic process (GO:0019673)2.77000894
113tRNA processing (GO:0008033)2.76521809
114deoxyribose phosphate metabolic process (GO:0019692)2.75682732
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75172253
116regulation of mitochondrial translation (GO:0070129)2.73633691
117deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.72332073
118cullin deneddylation (GO:0010388)2.72076782
119protein peptidyl-prolyl isomerization (GO:0000413)2.71966740
120myelin assembly (GO:0032288)2.71572652
121deoxyribose phosphate biosynthetic process (GO:0046385)2.70326751
1222-deoxyribonucleotide biosynthetic process (GO:0009265)2.70326751
123regulation of monocyte chemotaxis (GO:0090025)2.69280105
124protein localization to cilium (GO:0061512)2.68847558
125cell differentiation involved in metanephros development (GO:0072202)2.68153710
126pseudouridine synthesis (GO:0001522)2.67112765
127induction of positive chemotaxis (GO:0050930)2.66556181
128regulation of autophagic vacuole assembly (GO:2000785)2.66164193
129protein neddylation (GO:0045116)2.64956250
130establishment of endothelial barrier (GO:0061028)2.64598609
131positive regulation of action potential (GO:0045760)2.64409761
132negative regulation of calcium ion transport into cytosol (GO:0010523)2.63796329
133rRNA modification (GO:0000154)2.63660465
134positive regulation of Rho protein signal transduction (GO:0035025)2.63110924
135membrane budding (GO:0006900)2.61412708
136UV protection (GO:0009650)2.61291692
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59881493
138negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59768215
139negative regulation of ligase activity (GO:0051352)2.59768215
140apoptotic DNA fragmentation (GO:0006309)2.59621374
141negative regulation of cAMP-mediated signaling (GO:0043951)2.59312067
142cilium assembly (GO:0042384)2.58572194
143mesenchymal cell differentiation involved in kidney development (GO:0072161)2.57870845
144mesenchymal cell differentiation involved in renal system development (GO:2001012)2.57870845
145polyamine biosynthetic process (GO:0006596)2.57596695
146negative regulation of transcription by competitive promoter binding (GO:0010944)2.56776026
147regulation of defense response to virus by host (GO:0050691)2.56679317
148negative regulation of execution phase of apoptosis (GO:1900118)2.56519383
149pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.55484995
150pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.54970105
151ATP synthesis coupled proton transport (GO:0015986)2.54291476
152energy coupled proton transport, down electrochemical gradient (GO:0015985)2.54291476
153magnesium ion transport (GO:0015693)2.54234063
154protein retention in ER lumen (GO:0006621)2.52873024
155deoxyribonucleotide metabolic process (GO:0009262)2.52453423
156RNA methylation (GO:0001510)2.52202552
157tRNA modification (GO:0006400)2.51986886
158antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.51879783
159middle ear morphogenesis (GO:0042474)2.51434747
160pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.51334425
161pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.50469592
162protein import into peroxisome matrix (GO:0016558)2.50163042
163regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.49794479
164positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49300910
165cilium organization (GO:0044782)2.49213023
1667-methylguanosine RNA capping (GO:0009452)2.47553580
167RNA capping (GO:0036260)2.47553580
168rRNA methylation (GO:0031167)2.46587482
169negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45957081
170negative regulation of cell killing (GO:0031342)2.45957081
171behavioral response to nicotine (GO:0035095)2.45929726
172DNA strand elongation involved in DNA replication (GO:0006271)2.45372949
173negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44194521
174protein complex localization (GO:0031503)2.43698715
175mitotic chromosome condensation (GO:0007076)2.43425604
176pyrimidine nucleotide catabolic process (GO:0006244)2.43171472
177purine nucleotide salvage (GO:0032261)2.42716411
1787-methylguanosine mRNA capping (GO:0006370)2.41639272
179negative regulation of dendrite morphogenesis (GO:0050774)2.40535938
180pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.40406088
181cytokinetic process (GO:0032506)2.40361673
182regulation of monocyte differentiation (GO:0045655)2.39627661
183DNA strand elongation (GO:0022616)2.37326709
184metaphase plate congression (GO:0051310)2.37258268

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.63075150
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.72686965
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.69903492
4EZH2_22144423_ChIP-Seq_EOC_Human3.66715878
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.43829759
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.41243359
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37261151
8* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23594386
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79497525
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76744231
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56033050
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53960909
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.53340512
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.44980889
15E2F7_22180533_ChIP-Seq_HELA_Human2.42129233
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41294799
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29569532
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24117959
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16148967
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10086154
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09346246
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05856295
23GBX2_23144817_ChIP-Seq_PC3_Human2.05664771
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.05487551
25CIITA_25753668_ChIP-Seq_RAJI_Human2.05252372
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03805561
27ESR1_20079471_ChIP-ChIP_T-47D_Human2.00191136
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.95136100
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.92294342
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91026601
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88555710
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85670462
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84862004
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.80662948
35* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78711447
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76755107
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76743946
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73526389
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72837686
40VDR_23849224_ChIP-Seq_CD4+_Human1.72356379
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62076487
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61885410
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61826081
44VDR_22108803_ChIP-Seq_LS180_Human1.60570894
45TAF15_26573619_Chip-Seq_HEK293_Human1.60220001
46* GABP_19822575_ChIP-Seq_HepG2_Human1.59760734
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.57773897
48* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55144769
49DCP1A_22483619_ChIP-Seq_HELA_Human1.53945178
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48711576
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40369338
52STAT1_20625510_ChIP-Seq_HELA_Human1.37961091
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37942954
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37172504
55SPI1_23547873_ChIP-Seq_NB4_Human1.36290916
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.35855889
57P300_19829295_ChIP-Seq_ESCs_Human1.34126125
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32276033
59* FOXP3_21729870_ChIP-Seq_TREG_Human1.31601999
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31445939
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26114947
62* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25650108
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25434034
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24634204
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24184919
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23357104
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22845730
68IRF8_27001747_Chip-Seq_BMDM_Mouse1.22408906
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.22262333
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22256498
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21065791
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.20977444
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20141989
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19072169
75SPI1_20517297_ChIP-Seq_HL60_Human1.18596664
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18456861
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.16128806
78* CBX2_27304074_Chip-Seq_ESCs_Mouse1.15593035
79MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15547010
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15474174
81* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13771461
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13707433
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12756129
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12530200
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11989660
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.11316249
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.11304752
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11248348
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10896749
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10650110
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09776879
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09327752
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09115351
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07698359
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07316437
96* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07307809
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.06555051
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06274569
99P53_22387025_ChIP-Seq_ESCs_Mouse1.05608646
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05496088
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04864861
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03940831
103* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03619706
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.02939176
105RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02524088
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02216146
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01649192
108KDM5A_27292631_Chip-Seq_BREAST_Human1.00027681
109HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98987884
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98476275
111TAL1_26923725_Chip-Seq_HPCs_Mouse0.98379944
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97743507
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97651174
114MYC_22102868_ChIP-Seq_BL_Human0.97488152
115VDR_21846776_ChIP-Seq_THP-1_Human0.97211358
116EZH2_27294783_Chip-Seq_NPCs_Mouse0.96904434
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96843210
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96790453
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96570226
120ETS1_21867929_ChIP-Seq_TH2_Mouse0.96175041
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93699132
122* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93308579
123* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92922751
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92181699
125CRX_20693478_ChIP-Seq_RETINA_Mouse0.92027941
126FOXM1_23109430_ChIP-Seq_U2OS_Human0.91654193
127TP53_22573176_ChIP-Seq_HFKS_Human0.91555902
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91454432
129PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91412666
130EZH2_27304074_Chip-Seq_ESCs_Mouse0.91357620
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91284895
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91235075
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.90793402
134ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90787768
135IGF1R_20145208_ChIP-Seq_DFB_Human0.90495398
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90152828
137SOX2_21211035_ChIP-Seq_LN229_Human0.89891107
138ER_23166858_ChIP-Seq_MCF-7_Human0.89861223
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.89430980
140SOX2_18555785_Chip-Seq_ESCs_Mouse0.89286770
141* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89183894
142P300_18555785_Chip-Seq_ESCs_Mouse0.88228852
143NMYC_18555785_Chip-Seq_ESCs_Mouse0.87978455
144CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87928352
145E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87882162
146EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87727826
147VDR_24763502_ChIP-Seq_THP-1_Human0.87455507
148JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86558825
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.86371289
150GATA3_26560356_Chip-Seq_TH2_Human0.86370443
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86330999
152REST_21632747_ChIP-Seq_MESCs_Mouse0.86031366
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85656635
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85287220
155MYC_18940864_ChIP-ChIP_HL60_Human0.85222736
156ELK1_19687146_ChIP-ChIP_HELA_Human0.84931285
157MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84881626
158* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84859850
159ZFX_18555785_Chip-Seq_ESCs_Mouse0.84542906
160WT1_19549856_ChIP-ChIP_CCG9911_Human0.84271820
161JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84234994
162EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84210163
163PU1_27457419_Chip-Seq_LIVER_Mouse0.83973449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition7.05651999
2MP0005623_abnormal_meninges_morphology4.80445274
3MP0001188_hyperpigmentation3.31765213
4MP0003880_abnormal_central_pattern3.21767710
5MP0006276_abnormal_autonomic_nervous3.10243361
6MP0005058_abnormal_lysosome_morphology3.00589787
7MP0010386_abnormal_urinary_bladder2.96457514
8MP0003786_premature_aging2.95549062
9MP0002736_abnormal_nociception_after2.94686606
10MP0001968_abnormal_touch/_nociception2.90048973
11MP0005645_abnormal_hypothalamus_physiol2.70265005
12MP0003806_abnormal_nucleotide_metabolis2.67120705
13MP0005083_abnormal_biliary_tract2.61387684
14MP0002735_abnormal_chemical_nociception2.51968208
15MP0002837_dystrophic_cardiac_calcinosis2.46638672
16MP0009840_abnormal_foam_cell2.37338468
17MP0002638_abnormal_pupillary_reflex2.36656162
18MP0000750_abnormal_muscle_regeneration2.26761127
19MP0005646_abnormal_pituitary_gland2.26387770
20MP0004947_skin_inflammation2.26325261
21MP0005084_abnormal_gallbladder_morpholo2.17715628
22MP0008875_abnormal_xenobiotic_pharmacok2.08555714
23MP0000015_abnormal_ear_pigmentation2.01261855
24MP0009764_decreased_sensitivity_to1.95494912
25MP0002148_abnormal_hypersensitivity_rea1.94898382
26MP0003123_paternal_imprinting1.93536807
27MP0002163_abnormal_gland_morphology1.93520888
28MP0002876_abnormal_thyroid_physiology1.89681182
29MP0009384_cardiac_valve_regurgitation1.89595757
30MP0000858_altered_metastatic_potential1.84945483
31MP0006292_abnormal_olfactory_placode1.83494207
32MP0000343_altered_response_to1.80841602
33MP0008961_abnormal_basal_metabolism1.80289495
34MP0005379_endocrine/exocrine_gland_phen1.80020035
35MP0001986_abnormal_taste_sensitivity1.79343689
36MP0003436_decreased_susceptibility_to1.71925528
37MP0003122_maternal_imprinting1.71500616
38MP0001835_abnormal_antigen_presentation1.68382930
39MP0008260_abnormal_autophagy1.68216422
40MP0002693_abnormal_pancreas_physiology1.58612422
41MP0003787_abnormal_imprinting1.57232537
42MP0002877_abnormal_melanocyte_morpholog1.57134810
43MP0004142_abnormal_muscle_tone1.55306819
44MP0010307_abnormal_tumor_latency1.53838447
45MP0008058_abnormal_DNA_repair1.53536391
46MP0002734_abnormal_mechanical_nocicepti1.52591867
47MP0005365_abnormal_bile_salt1.51153305
48MP0002132_abnormal_respiratory_system1.50567235
49MP0001970_abnormal_pain_threshold1.50313791
50MP0003638_abnormal_response/metabolism_1.47534512
51MP0002089_abnormal_postnatal_growth/wei1.46544486
52MP0003221_abnormal_cardiomyocyte_apopto1.45742050
53MP0004134_abnormal_chest_morphology1.41400237
54MP0009379_abnormal_foot_pigmentation1.40467356
55MP0001502_abnormal_circadian_rhythm1.40291846
56MP0004147_increased_porphyrin_level1.39973220
57MP0003315_abnormal_perineum_morphology1.38818068
58MP0005025_abnormal_response_to1.37977131
59MP0002160_abnormal_reproductive_system1.37628661
60MP0001270_distended_abdomen1.37419650
61MP0001944_abnormal_pancreas_morphology1.35886621
62MP0002419_abnormal_innate_immunity1.34830535
63MP0004019_abnormal_vitamin_homeostasis1.34045255
64MP0004742_abnormal_vestibular_system1.34009660
65MP0002452_abnormal_antigen_presenting1.33042824
66MP0001529_abnormal_vocalization1.32397814
67MP0009250_abnormal_appendicular_skeleto1.32150791
68MP0002272_abnormal_nervous_system1.32026352
69MP0002909_abnormal_adrenal_gland1.30779458
70MP0001664_abnormal_digestion1.30696162
71MP0001800_abnormal_humoral_immune1.29443781
72MP0008007_abnormal_cellular_replicative1.28651429
73MP0001542_abnormal_bone_strength1.27101226
74MP0000631_abnormal_neuroendocrine_gland1.26911828
75MP0002733_abnormal_thermal_nociception1.25660163
76MP0006082_CNS_inflammation1.25588431
77MP0001545_abnormal_hematopoietic_system1.24078429
78MP0005397_hematopoietic_system_phenotyp1.24078429
79MP0002723_abnormal_immune_serum1.23949905
80MP0003183_abnormal_peptide_metabolism1.23587064
81MP0005584_abnormal_enzyme/coenzyme_acti1.23463264
82MP0008873_increased_physiological_sensi1.22865787
83MP0003656_abnormal_erythrocyte_physiolo1.21889860
84MP0005409_darkened_coat_color1.17984902
85MP0002751_abnormal_autonomic_nervous1.17108651
86MP0001764_abnormal_homeostasis1.16104274
87MP0005000_abnormal_immune_tolerance1.15506784
88MP0005671_abnormal_response_to1.14840963
89MP0000681_abnormal_thyroid_gland1.13744723
90MP0005387_immune_system_phenotype1.12998161
91MP0001790_abnormal_immune_system1.12998161
92MP0003385_abnormal_body_wall1.12016026
93MP0005220_abnormal_exocrine_pancreas1.10289577
94MP0002139_abnormal_hepatobiliary_system1.09521997
95MP0003136_yellow_coat_color1.08386273
96MP0003121_genomic_imprinting1.06325057
97MP0001819_abnormal_immune_cell1.06288268
98MP0005319_abnormal_enzyme/_coenzyme1.06094756
99MP0003186_abnormal_redox_activity1.05776190
100MP0005636_abnormal_mineral_homeostasis1.04691067
101MP0002067_abnormal_sensory_capabilities1.04649038
102MP0002420_abnormal_adaptive_immunity1.04586212
103MP0000049_abnormal_middle_ear1.04457288
104MP0001501_abnormal_sleep_pattern1.04013209
105MP0009765_abnormal_xenobiotic_induced1.03821239
106MP0003195_calcinosis1.03819261
107MP0002933_joint_inflammation1.02950080
108MP0002938_white_spotting1.01754879
109MP0005389_reproductive_system_phenotype1.01662276
110MP0006036_abnormal_mitochondrial_physio1.01601536
111MP0002572_abnormal_emotion/affect_behav1.01568163
112MP0000372_irregular_coat_pigmentation1.01363895
113MP0003724_increased_susceptibility_to1.01237603
114MP0000313_abnormal_cell_death1.01076538
115MP0005464_abnormal_platelet_physiology1.01018504
116MP0002184_abnormal_innervation0.99749486
117MP0009697_abnormal_copulation0.99488274
118MP0010155_abnormal_intestine_physiology0.99407753
119MP0000678_abnormal_parathyroid_gland0.99020109
120MP0002557_abnormal_social/conspecific_i0.98850200
121MP0009785_altered_susceptibility_to0.98224826
122MP0005670_abnormal_white_adipose0.97713745
123MP0001905_abnormal_dopamine_level0.97686170
124MP0002177_abnormal_outer_ear0.97581480
125MP0009745_abnormal_behavioral_response0.96545154
126MP0005410_abnormal_fertilization0.94775657
127MP0010094_abnormal_chromosome_stability0.94729753
128MP0000013_abnormal_adipose_tissue0.94245157
129MP0003693_abnormal_embryo_hatching0.93938069
130MP0008469_abnormal_protein_level0.93714023
131MP0001919_abnormal_reproductive_system0.92897213
132MP0002078_abnormal_glucose_homeostasis0.92286060
133MP0003868_abnormal_feces_composition0.90951576
134MP0000716_abnormal_immune_system0.90770016
135MP0001666_abnormal_nutrient_absorption0.90339567
136MP0005164_abnormal_response_to0.89848114
137MP0005448_abnormal_energy_balance0.89017398
138MP0009763_increased_sensitivity_to0.88900832
139MP0004859_abnormal_synaptic_plasticity0.88584081
140MP0003878_abnormal_ear_physiology0.88245173
141MP0005377_hearing/vestibular/ear_phenot0.88245173
142MP0000566_synostosis0.88093343
143MP0000358_abnormal_cell_content/0.87898432
144MP0002019_abnormal_tumor_incidence0.87486725
145MP0002429_abnormal_blood_cell0.85202185
146MP0001533_abnormal_skeleton_physiology0.85080339
147MP0003635_abnormal_synaptic_transmissio0.84930115
148MP0001929_abnormal_gametogenesis0.84653351
149MP0002277_abnormal_respiratory_mucosa0.83983732
150MP0008004_abnormal_stomach_pH0.83910810
151MP0000163_abnormal_cartilage_morphology0.83770788
152MP0002998_abnormal_bone_remodeling0.83729969
153MP0002064_seizures0.83652030
154MP0006035_abnormal_mitochondrial_morpho0.83141323
155MP0003795_abnormal_bone_structure0.82648185
156MP0002063_abnormal_learning/memory/cond0.81675792
157MP0004782_abnormal_surfactant_physiolog0.80601953
158MP0000685_abnormal_immune_system0.80318718
159MP0001727_abnormal_embryo_implantation0.78703737
160MP0003942_abnormal_urinary_system0.78701642
161MP0004808_abnormal_hematopoietic_stem0.78486630
162MP0005535_abnormal_body_temperature0.78250300
163MP0000490_abnormal_crypts_of0.77554563
164MP0002269_muscular_atrophy0.77462525
165MP0005332_abnormal_amino_acid0.77031170
166MP0002095_abnormal_skin_pigmentation0.75833441
167MP0002234_abnormal_pharynx_morphology0.75516978
168MP0003191_abnormal_cellular_cholesterol0.75467623
169MP0004043_abnormal_pH_regulation0.74928408
170MP0002398_abnormal_bone_marrow0.74638017
171MP0002970_abnormal_white_adipose0.74606507
172MP0004270_analgesia0.74422279
173MP0003111_abnormal_nucleus_morphology0.73863256
174MP0003763_abnormal_thymus_physiology0.73430829
175MP0009333_abnormal_splenocyte_physiolog0.73098415
176MP0003953_abnormal_hormone_level0.72624231
177MP0003453_abnormal_keratinocyte_physiol0.71769092
178MP0002210_abnormal_sex_determination0.71411739
179MP0005174_abnormal_tail_pigmentation0.70730826
180MP0009780_abnormal_chondrocyte_physiolo0.70143605
181MP0003699_abnormal_female_reproductive0.69988236
182MP0003828_pulmonary_edema0.69800024
183MP0009278_abnormal_bone_marrow0.69463422

Predicted human phenotypes

RankGene SetZ-score
1Retinal atrophy (HP:0001105)8.26932919
2Fatigue (HP:0012378)7.98926923
3Cerebellar dysplasia (HP:0007033)7.58764386
4Entropion (HP:0000621)5.61948360
5Difficulty climbing stairs (HP:0003551)4.69014516
6Buphthalmos (HP:0000557)4.58621272
7Decreased electroretinogram (ERG) amplitude (HP:0000654)4.31609287
83-Methylglutaconic aciduria (HP:0003535)3.92761374
9Multiple enchondromatosis (HP:0005701)3.68278772
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.55791120
11Mitochondrial inheritance (HP:0001427)3.37422601
12Acute necrotizing encephalopathy (HP:0006965)3.36775711
13Poikiloderma (HP:0001029)3.36503431
14Irregular vertebral endplates (HP:0003301)3.31471407
15Abnormal protein glycosylation (HP:0012346)3.31076757
16Abnormal glycosylation (HP:0012345)3.31076757
17Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.31076757
18Abnormal protein N-linked glycosylation (HP:0012347)3.31076757
19Type I transferrin isoform profile (HP:0003642)3.28874577
20Abnormality of the vertebral endplates (HP:0005106)3.22789009
21Abnormality of lateral ventricle (HP:0030047)3.12469340
22Reduced antithrombin III activity (HP:0001976)3.11851526
23Hypothermia (HP:0002045)3.10658167
24Megalocornea (HP:0000485)3.07486999
25Focal motor seizures (HP:0011153)3.06435160
26Trismus (HP:0000211)3.01913532
27Increased IgM level (HP:0003496)3.01493411
28Acute encephalopathy (HP:0006846)2.99421859
29Hepatocellular necrosis (HP:0001404)2.98938428
30Rhinitis (HP:0012384)2.97793879
31True hermaphroditism (HP:0010459)2.97220566
32Increased CSF lactate (HP:0002490)2.94632362
33Abnormal respiratory motile cilium physiology (HP:0012261)2.94130901
34Submucous cleft hard palate (HP:0000176)2.89197227
35Flat capital femoral epiphysis (HP:0003370)2.88369533
36Pancreatic cysts (HP:0001737)2.85338798
37Abnormal respiratory epithelium morphology (HP:0012253)2.84742002
38Abnormal respiratory motile cilium morphology (HP:0005938)2.84742002
39Vascular calcification (HP:0004934)2.82041573
40Renal Fanconi syndrome (HP:0001994)2.82025197
41Abnormal mitochondria in muscle tissue (HP:0008316)2.81767631
42Pancreatic fibrosis (HP:0100732)2.77900514
43Type II lissencephaly (HP:0007260)2.77577789
44Hepatic necrosis (HP:0002605)2.77449261
45Abnormal ciliary motility (HP:0012262)2.76776137
46Conjugated hyperbilirubinemia (HP:0002908)2.69729524
47Medial flaring of the eyebrow (HP:0010747)2.69575386
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.68864091
49Retinal dysplasia (HP:0007973)2.67516712
50Ragged-red muscle fibers (HP:0003200)2.64482468
51Progressive macrocephaly (HP:0004481)2.62019338
52Aplasia/Hypoplasia affecting the retina (HP:0008061)2.60520618
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59504562
54Abolished electroretinogram (ERG) (HP:0000550)2.58278528
55Aplasia/hypoplasia of the uterus (HP:0008684)2.56310740
56Delayed CNS myelination (HP:0002188)2.55922632
57Metaphyseal dysplasia (HP:0100255)2.54248500
58Premature ovarian failure (HP:0008209)2.54210886
59Granulocytopenia (HP:0001913)2.51881008
60Severe muscular hypotonia (HP:0006829)2.51118403
61Severe global developmental delay (HP:0011344)2.51073801
62Irregular epiphyses (HP:0010582)2.51046764
63Neonatal hypoglycemia (HP:0001998)2.51020251
64Increased serum pyruvate (HP:0003542)2.48866773
65Lactic acidosis (HP:0003128)2.47828070
66Hyperventilation (HP:0002883)2.46181046
67Increased hepatocellular lipid droplets (HP:0006565)2.45682850
68Congenital glaucoma (HP:0001087)2.45264213
69Disinhibition (HP:0000734)2.45096364
70Poor head control (HP:0002421)2.43251717
71Mesangial abnormality (HP:0001966)2.42415455
72Cardiovascular calcification (HP:0011915)2.41869053
73Aplasia/Hypoplasia of the brainstem (HP:0007362)2.40508250
74Hypoplasia of the brainstem (HP:0002365)2.40508250
75Slow saccadic eye movements (HP:0000514)2.30247328
76Nephronophthisis (HP:0000090)2.29396229
77Abnormal tarsal ossification (HP:0008369)2.28659227
78Eosinophilia (HP:0001880)2.28628886
79Lipid accumulation in hepatocytes (HP:0006561)2.28054377
80Abnormality of renal resorption (HP:0011038)2.27146870
81Abnormality of the pons (HP:0007361)2.26612913
82Personality changes (HP:0000751)2.24165354
83IgG deficiency (HP:0004315)2.23756176
84Occipital encephalocele (HP:0002085)2.23686236
85Hypoplasia of the pons (HP:0012110)2.23311567
86Optic nerve hypoplasia (HP:0000609)2.22127012
87Non-midline cleft lip (HP:0100335)2.22041257
88Nephrogenic diabetes insipidus (HP:0009806)2.21755549
89Abnormal hair whorl (HP:0010721)2.20768764
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20602863
91Xerostomia (HP:0000217)2.20004519
92Intellectual disability, profound (HP:0002187)2.17660364
93Brittle hair (HP:0002299)2.16850655
94Hyperglycinemia (HP:0002154)2.16226432
95Abnormality of DNA repair (HP:0003254)2.14957444
96Abnormality of aromatic amino acid family metabolism (HP:0004338)2.11967062
97Increased serum lactate (HP:0002151)2.09217656
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08739837
99Abnormality of alanine metabolism (HP:0010916)2.08739837
100Hyperalaninemia (HP:0003348)2.08739837
101Epiphyseal dysplasia (HP:0002656)2.07251501
102Dynein arm defect of respiratory motile cilia (HP:0012255)2.06756999
103Absent/shortened dynein arms (HP:0200106)2.06756999
104Generalized hypotonia (HP:0001290)2.06200145
105Methylmalonic aciduria (HP:0012120)2.04198150
106Abnormality of glycolipid metabolism (HP:0010969)2.03794790
107Abnormality of liposaccharide metabolism (HP:0010968)2.03794790
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.03794790
109Hypertensive crisis (HP:0100735)2.02797680
110Lissencephaly (HP:0001339)2.02042104
111Abnormality of dental color (HP:0011073)2.01119087
112Neuroendocrine neoplasm (HP:0100634)2.00163846
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.98992778
114Exertional dyspnea (HP:0002875)1.98052576
115Progressive muscle weakness (HP:0003323)1.96567116
116Autoimmune thrombocytopenia (HP:0001973)1.95885113
117Poor suck (HP:0002033)1.94844985
118Genu varum (HP:0002970)1.94252642
119Abnormality of the vitreous humor (HP:0004327)1.93863752
120Atonic seizures (HP:0010819)1.92461987
121Apathy (HP:0000741)1.92083808
122Abnormality of the femoral head (HP:0003368)1.90840169
123Opisthotonus (HP:0002179)1.89961159
124Vacuolated lymphocytes (HP:0001922)1.89688297
125Respiratory failure (HP:0002878)1.89605190
126Sensory axonal neuropathy (HP:0003390)1.88018227
127Stomach cancer (HP:0012126)1.87341972
128Cerebral edema (HP:0002181)1.86687778
129Abnormality of the epiphysis of the femoral head (HP:0010574)1.86598806
130Congenital, generalized hypertrichosis (HP:0004540)1.85446833
131Flared iliac wings (HP:0002869)1.85178036
132Abnormality of B cell number (HP:0010975)1.84293608
133Carpal bone hypoplasia (HP:0001498)1.83647677
134Ectropion (HP:0000656)1.83500642
135Pulmonary fibrosis (HP:0002206)1.83272098
136Flattened epiphyses (HP:0003071)1.82678199
137Pachygyria (HP:0001302)1.81316316
138Diminished motivation (HP:0000745)1.80349586
139Cortical visual impairment (HP:0100704)1.79648725
140Molar tooth sign on MRI (HP:0002419)1.79012447
141Abnormality of midbrain morphology (HP:0002418)1.79012447
142Combined immunodeficiency (HP:0005387)1.78877693
143Chronic bronchitis (HP:0004469)1.78179477
144Short tibia (HP:0005736)1.77868917
145Congenital primary aphakia (HP:0007707)1.76817529
146Hypoglycemic seizures (HP:0002173)1.76117409
147Microvesicular hepatic steatosis (HP:0001414)1.75983013
148Metaphyseal irregularity (HP:0003025)1.74831588
149Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.74366755
150Abnormality of femoral epiphyses (HP:0006499)1.74366755
151Gait imbalance (HP:0002141)1.74307017
152Erythroderma (HP:0001019)1.73847612
153Short nail (HP:0001799)1.73846283
154Split foot (HP:0001839)1.73135342
155Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72939062
156Inappropriate behavior (HP:0000719)1.72804420
157Small epiphyses (HP:0010585)1.70825167
158Cleft eyelid (HP:0000625)1.70506199
159Exercise intolerance (HP:0003546)1.70172376
160Hyperphosphaturia (HP:0003109)1.70138402
161Upper motor neuron abnormality (HP:0002127)1.69825170
162Barrel-shaped chest (HP:0001552)1.69298744
163Abnormality of the renal medulla (HP:0100957)1.68770235
164Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68761239
165Decreased subcutaneous fat (HP:0001002)1.68590292
166Supranuclear gaze palsy (HP:0000605)1.67809347
167Absent eyelashes (HP:0000561)1.66879919
168Respiratory difficulties (HP:0002880)1.66860328
169Keratitis (HP:0000491)1.61528796
170Rough bone trabeculation (HP:0100670)1.61268467
171Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.60715827
172Abnormality of eosinophils (HP:0001879)1.60244651
173Male infertility (HP:0003251)1.60216216
174Overriding aorta (HP:0002623)1.59545826
175Conical tooth (HP:0000698)1.57437835
176Abnormality of glycosaminoglycan metabolism (HP:0004371)1.56608680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK106.21231188
2MARK34.88609686
3MST44.86812273
4TLK13.90628502
5CLK13.87755260
6STK163.68185492
7BMPR23.39849310
8MAP2K73.10691224
9CASK3.07642397
10NTRK32.86874128
11EIF2AK32.35132678
12SRPK12.33022979
13BCKDK2.18244044
14ABL22.11065196
15BLK2.09452104
16ZAK1.98478959
17MAPK131.96513685
18TAOK11.95291785
19IRAK11.87171612
20TNIK1.83452789
21PIM11.81608253
22FES1.79099770
23BMPR1B1.78584488
24DYRK21.71579410
25MAP3K141.70839458
26AKT31.64735484
27MAPKAPK31.57605308
28PRKD31.55418097
29MUSK1.55335141
30IRAK31.54377342
31BRAF1.51271400
32CDK81.48814529
33VRK11.46997220
34MAPK151.46483464
35CDC71.45530476
36PIM21.44438627
37DYRK31.36221567
38MAP3K41.30793769
39NLK1.29695552
40STK38L1.29600771
41WNK41.29537436
42CDK191.29478777
43MAP3K31.28017451
44PTK2B1.27167477
45ADRBK21.26769271
46PLK11.20626485
47YES11.20594133
48STK111.20151393
49SIK31.15399818
50IKBKB1.13021104
51PRPF4B1.11323288
52EEF2K1.10889339
53BRSK21.09935948
54NME11.09367050
55EPHA41.08630001
56IRAK41.08539515
57WNK31.08249902
58TTK1.05010360
59ERBB21.04241990
60MATK1.03574088
61CSF1R1.01837426
62LIMK11.00793398
63EPHA30.94588720
64MET0.94414065
65TEC0.93326459
66PLK40.92206235
67INSRR0.92198690
68AKT20.91047224
69MAP3K20.90208388
70EGFR0.89755531
71PIK3CG0.88053057
72DYRK1A0.86100671
73TYK20.84590683
74MKNK20.84033009
75TAOK30.80976770
76GRK60.80523842
77PRKCI0.80459118
78ARAF0.77765906
79ERN10.76400064
80BUB10.75804864
81TXK0.74667493
82KIT0.74285794
83CSNK1A1L0.71931443
84SCYL20.71613489
85ZAP700.70008187
86LMTK20.69101504
87PRKCE0.69099993
88CHEK10.68937568
89MAPK110.66864959
90CSNK1G30.66840168
91WEE10.66332818
92IRAK20.65870774
93NME20.65717168
94MAP3K120.63321163
95CAMK2B0.63228082
96NUAK10.62195535
97PLK20.62083083
98CDK11A0.61621206
99FRK0.61439834
100TBK10.61017734
101CSNK1G20.60879658
102CDK90.60716484
103AURKB0.60684185
104AURKA0.60514692
105RIPK10.58886770
106MAP3K50.58261209
107JAK30.57551297
108TESK10.57510540
109PRKCG0.57103194
110CDK30.56942446
111FER0.56599610
112MAP3K60.56595616
113ATR0.55589047
114MAP3K130.54948014
115PASK0.54510892
116CDK140.54018081
117PINK10.53012331
118CAMK2D0.52456544
119CDK150.51032393
120CDK70.50819778
121GRK70.49617696
122PRKD20.49024312
123MST1R0.48375873
124CHUK0.48308789
125RPS6KB20.47746867
126NEK10.46955243
127UHMK10.46815399
128MINK10.46584209
129CAMK2G0.45201034
130CDK180.44966400
131MARK10.44760610
132MAP3K80.43491683
133IKBKE0.42781570
134BRSK10.41664517
135BTK0.41360334
136CSNK1A10.41164890
137MAP3K110.41062343
138PDK20.40555759
139RPS6KA40.40157072
140MKNK10.39590661
141MAPKAPK50.39357754
142EIF2AK20.38611700
143CHEK20.38594073
144EIF2AK10.38590193
145CSNK2A10.38403992
146RPS6KB10.37855579
147EPHA20.37728893
148CDC42BPA0.37688316
149MAP2K20.37398206
150TESK20.37197735
151DDR20.37195741
152TAOK20.36549301
153MAPK140.36495572
154SYK0.36134144
155LCK0.34986952
156CSNK1E0.33165847
157PTK20.32897926
158PRKCQ0.31494305
159CSNK2A20.31349896
160TGFBR10.30825820
161MAP4K10.28661200
162RPS6KA20.27188119
163CDK40.25927762
164TSSK60.23851449

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.86594613
2Proteasome_Homo sapiens_hsa030503.43084657
3Asthma_Homo sapiens_hsa053103.40567593
4Oxidative phosphorylation_Homo sapiens_hsa001902.97019072
5Graft-versus-host disease_Homo sapiens_hsa053322.61710879
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.61518632
7Allograft rejection_Homo sapiens_hsa053302.48252882
8Folate biosynthesis_Homo sapiens_hsa007902.42239699
9Leishmaniasis_Homo sapiens_hsa051402.40671678
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.39004047
11Parkinsons disease_Homo sapiens_hsa050122.34821390
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.25086510
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22445834
14Antigen processing and presentation_Homo sapiens_hsa046122.09783947
15TNF signaling pathway_Homo sapiens_hsa046682.06301161
16Staphylococcus aureus infection_Homo sapiens_hsa051502.05108603
17RNA polymerase_Homo sapiens_hsa030202.04337584
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.01844601
19Vibrio cholerae infection_Homo sapiens_hsa051102.01471055
20Pyrimidine metabolism_Homo sapiens_hsa002401.98112206
21Regulation of autophagy_Homo sapiens_hsa041401.97192928
22Herpes simplex infection_Homo sapiens_hsa051681.89292130
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.88640701
24Toxoplasmosis_Homo sapiens_hsa051451.80027345
25Sulfur relay system_Homo sapiens_hsa041221.79552425
26Huntingtons disease_Homo sapiens_hsa050161.78749268
27Shigellosis_Homo sapiens_hsa051311.78261507
28Viral myocarditis_Homo sapiens_hsa054161.77374319
29DNA replication_Homo sapiens_hsa030301.76964254
30Alzheimers disease_Homo sapiens_hsa050101.75314106
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73351789
32Epstein-Barr virus infection_Homo sapiens_hsa051691.70250543
33N-Glycan biosynthesis_Homo sapiens_hsa005101.69759251
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.67552707
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65452105
36* SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63908663
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61686632
38Sulfur metabolism_Homo sapiens_hsa009201.47160392
39Ribosome_Homo sapiens_hsa030101.46596032
40Osteoclast differentiation_Homo sapiens_hsa043801.45835542
41Other glycan degradation_Homo sapiens_hsa005111.45544605
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42759038
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41548268
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40162375
45Collecting duct acid secretion_Homo sapiens_hsa049661.38940039
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.37883740
47Purine metabolism_Homo sapiens_hsa002301.37675426
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36552044
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35041461
50Propanoate metabolism_Homo sapiens_hsa006401.29098967
51Homologous recombination_Homo sapiens_hsa034401.29076052
52Basal transcription factors_Homo sapiens_hsa030221.28825645
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26574571
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25547612
55Mismatch repair_Homo sapiens_hsa034301.24497571
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23781155
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19253065
58Nucleotide excision repair_Homo sapiens_hsa034201.14248823
59Tuberculosis_Homo sapiens_hsa051521.12432373
60Synaptic vesicle cycle_Homo sapiens_hsa047211.12379663
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10445001
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08769453
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05721823
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01639732
65Metabolic pathways_Homo sapiens_hsa011000.99307940
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96969685
67Arachidonic acid metabolism_Homo sapiens_hsa005900.96928707
68Nicotine addiction_Homo sapiens_hsa050330.95931286
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95427312
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95282259
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93709666
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93703876
73Influenza A_Homo sapiens_hsa051640.93018801
74Apoptosis_Homo sapiens_hsa042100.90603108
75Hematopoietic cell lineage_Homo sapiens_hsa046400.90329784
76Salmonella infection_Homo sapiens_hsa051320.89010848
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88619206
78Sphingolipid metabolism_Homo sapiens_hsa006000.87357850
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84360185
80Base excision repair_Homo sapiens_hsa034100.82470490
81B cell receptor signaling pathway_Homo sapiens_hsa046620.81305617
82Fatty acid elongation_Homo sapiens_hsa000620.81067114
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.79221659
84Peroxisome_Homo sapiens_hsa041460.77693303
85Hepatitis C_Homo sapiens_hsa051600.71783109
86Pancreatic secretion_Homo sapiens_hsa049720.69438222
87Circadian rhythm_Homo sapiens_hsa047100.68867726
88Insulin secretion_Homo sapiens_hsa049110.67693369
89mRNA surveillance pathway_Homo sapiens_hsa030150.65241807
90Pyruvate metabolism_Homo sapiens_hsa006200.65187270
91Hepatitis B_Homo sapiens_hsa051610.64681901
92Lysosome_Homo sapiens_hsa041420.63834407
93Histidine metabolism_Homo sapiens_hsa003400.62089091
94Adherens junction_Homo sapiens_hsa045200.60844692
95beta-Alanine metabolism_Homo sapiens_hsa004100.60323848
96Autoimmune thyroid disease_Homo sapiens_hsa053200.59604110
97Cocaine addiction_Homo sapiens_hsa050300.58905150
98Primary immunodeficiency_Homo sapiens_hsa053400.58300328
99Rheumatoid arthritis_Homo sapiens_hsa053230.57446894
100Olfactory transduction_Homo sapiens_hsa047400.57303000
101Phenylalanine metabolism_Homo sapiens_hsa003600.56054221
102Type I diabetes mellitus_Homo sapiens_hsa049400.55939663
103Serotonergic synapse_Homo sapiens_hsa047260.55737767
104HTLV-I infection_Homo sapiens_hsa051660.55144348
105Morphine addiction_Homo sapiens_hsa050320.55016308
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53262234
107Chemokine signaling pathway_Homo sapiens_hsa040620.53111559
108One carbon pool by folate_Homo sapiens_hsa006700.52929581
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52702953
110Systemic lupus erythematosus_Homo sapiens_hsa053220.52575387
111* Phagosome_Homo sapiens_hsa041450.52149719
112Amphetamine addiction_Homo sapiens_hsa050310.51371349
113Pancreatic cancer_Homo sapiens_hsa052120.51191815
114Acute myeloid leukemia_Homo sapiens_hsa052210.50916930
115Non-homologous end-joining_Homo sapiens_hsa034500.49558166
116Spliceosome_Homo sapiens_hsa030400.49442163
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49174524
118Tight junction_Homo sapiens_hsa045300.48759610
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48724212
120Vitamin B6 metabolism_Homo sapiens_hsa007500.48630972
121Small cell lung cancer_Homo sapiens_hsa052220.48530524
122Cell cycle_Homo sapiens_hsa041100.47654598
123Selenocompound metabolism_Homo sapiens_hsa004500.47412117
124Galactose metabolism_Homo sapiens_hsa000520.47197574
125Pertussis_Homo sapiens_hsa051330.46875891
126Bladder cancer_Homo sapiens_hsa052190.46838086
127Taste transduction_Homo sapiens_hsa047420.46124793
128Dopaminergic synapse_Homo sapiens_hsa047280.42983378
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42685857
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42145611
131Protein digestion and absorption_Homo sapiens_hsa049740.40921815
132Fanconi anemia pathway_Homo sapiens_hsa034600.40692011
133Tyrosine metabolism_Homo sapiens_hsa003500.39901017
134Circadian entrainment_Homo sapiens_hsa047130.39410103
135Arginine and proline metabolism_Homo sapiens_hsa003300.39399704
136RNA transport_Homo sapiens_hsa030130.39336451
137p53 signaling pathway_Homo sapiens_hsa041150.37687649
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37678041
139Alcoholism_Homo sapiens_hsa050340.37598234
140Vitamin digestion and absorption_Homo sapiens_hsa049770.36906101
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.35304239
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.35286545
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.34879027
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32316567
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32048595
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31930106
147Fat digestion and absorption_Homo sapiens_hsa049750.29158089
148Non-small cell lung cancer_Homo sapiens_hsa052230.29116557
149Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28180921
150Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28080284
151RNA degradation_Homo sapiens_hsa030180.27903122
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26186925
153Glutathione metabolism_Homo sapiens_hsa004800.23151612
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.23045039
155Pentose phosphate pathway_Homo sapiens_hsa000300.22902688
156GABAergic synapse_Homo sapiens_hsa047270.22497520

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