STX19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transepithelial transport (GO:0070633)6.66615801
2positive regulation of digestive system process (GO:0060456)6.61567133
3tachykinin receptor signaling pathway (GO:0007217)6.24968111
4positive regulation of synaptic transmission, GABAergic (GO:0032230)5.89722657
5sperm capacitation (GO:0048240)5.80774623
6positive regulation of action potential (GO:0045760)5.80746375
7carnitine shuttle (GO:0006853)5.28774385
8diterpenoid biosynthetic process (GO:0016102)5.24912200
9peptide catabolic process (GO:0043171)5.03646046
10bicarbonate transport (GO:0015701)4.73360611
11calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.71391568
12carnitine transmembrane transport (GO:1902603)4.64513570
13cellular glucuronidation (GO:0052695)4.56100638
14bundle of His cell to Purkinje myocyte communication (GO:0086069)4.50567668
15negative regulation of heart rate (GO:0010459)4.45445458
16carnitine transport (GO:0015879)4.43213105
17amino-acid betaine transport (GO:0015838)4.43213105
18regulation of axon regeneration (GO:0048679)4.34859765
19regulation of neuron projection regeneration (GO:0070570)4.34859765
20uronic acid metabolic process (GO:0006063)4.27103916
21glucuronate metabolic process (GO:0019585)4.27103916
22long-chain fatty acid biosynthetic process (GO:0042759)4.24334680
23sphingoid metabolic process (GO:0046519)4.23577791
24phosphate ion transmembrane transport (GO:0035435)4.17433640
25retinal metabolic process (GO:0042574)4.15728296
26fatty acid transmembrane transport (GO:1902001)4.12878556
27positive regulation of steroid hormone secretion (GO:2000833)4.12476878
28G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.95306680
29negative regulation of complement activation (GO:0045916)3.92200025
30cilium or flagellum-dependent cell motility (GO:0001539)3.88619483
31intestinal epithelial cell development (GO:0060576)3.82125120
32regulation of intracellular pH (GO:0051453)3.75716783
33establishment of skin barrier (GO:0061436)3.74054467
34nodal signaling pathway (GO:0038092)3.70059594
35response to nitrosative stress (GO:0051409)3.66287647
36regulation of protein glycosylation (GO:0060049)3.59683314
37positive regulation of vasodilation (GO:0045909)3.58801802
38auditory receptor cell differentiation (GO:0042491)3.58239488
39limb bud formation (GO:0060174)3.52295747
40phenylpropanoid metabolic process (GO:0009698)3.48913602
41positive regulation of renal sodium excretion (GO:0035815)3.47430848
42phosphate ion transport (GO:0006817)3.45292111
43superoxide anion generation (GO:0042554)3.43199190
44intestinal absorption (GO:0050892)3.42731493
45central nervous system myelination (GO:0022010)3.42472872
46axon ensheathment in central nervous system (GO:0032291)3.42472872
47sulfate transport (GO:0008272)3.42249545
48regulation of glucocorticoid secretion (GO:2000849)3.42226971
49negative regulation of protein activation cascade (GO:2000258)3.41201372
50quaternary ammonium group transport (GO:0015697)3.40778725
51regulation of cellular pH (GO:0030641)3.38270862
52terpenoid biosynthetic process (GO:0016114)3.33260998
53short-chain fatty acid metabolic process (GO:0046459)3.30866080
54regulation of guanylate cyclase activity (GO:0031282)3.29708403
55negative regulation of humoral immune response (GO:0002921)3.28506675
56retinol metabolic process (GO:0042572)3.28130357
57interferon-gamma secretion (GO:0072643)3.27337656
58regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.21857949
59startle response (GO:0001964)3.19172274
60regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.18652327
61sulfate transmembrane transport (GO:1902358)3.18478746
62ceramide catabolic process (GO:0046514)3.18260077
63daunorubicin metabolic process (GO:0044597)3.16026461
64polyketide metabolic process (GO:0030638)3.16026461
65doxorubicin metabolic process (GO:0044598)3.16026461
66axonemal dynein complex assembly (GO:0070286)3.13327089
67histone mRNA catabolic process (GO:0071044)3.12873872
68alkaloid metabolic process (GO:0009820)3.12857485
69keratinocyte development (GO:0003334)3.12391688
70sphingosine metabolic process (GO:0006670)3.12194868
71regulation of action potential (GO:0098900)3.10502114
72natural killer cell activation involved in immune response (GO:0002323)3.07387106
73axoneme assembly (GO:0035082)3.07210559
74protein heterotetramerization (GO:0051290)3.07148934
75drug catabolic process (GO:0042737)3.04625654
76transcytosis (GO:0045056)3.03790280
77righting reflex (GO:0060013)3.03714169
78intracellular lipid transport (GO:0032365)3.00984707
79excretion (GO:0007588)2.98962601
80regulation of systemic arterial blood pressure by hormone (GO:0001990)2.97594462
81regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.97594462
82endocrine process (GO:0050886)2.97594462
83diol metabolic process (GO:0034311)2.96990356
84multicellular organismal water homeostasis (GO:0050891)2.96439674
85ethanol oxidation (GO:0006069)2.95621614
86oxidative demethylation (GO:0070989)2.95161564
87renal system process involved in regulation of blood volume (GO:0001977)2.93176630
88fatty acid elongation (GO:0030497)2.92350083
89GPI anchor biosynthetic process (GO:0006506)2.91810284
90regulation of interleukin-8 secretion (GO:2000482)2.91313235
91centriole assembly (GO:0098534)2.89828578
92drug transmembrane transport (GO:0006855)2.88905691
93UDP-N-acetylglucosamine metabolic process (GO:0006047)2.88584262
94regulation of protein polyubiquitination (GO:1902914)2.88505639
95Golgi to endosome transport (GO:0006895)2.88286723
96regulation of timing of cell differentiation (GO:0048505)2.87470529
97regulation of water loss via skin (GO:0033561)2.86818456
98epithelial cell maturation (GO:0002070)2.86461086
99primary alcohol metabolic process (GO:0034308)2.86288032
100positive regulation of protein homodimerization activity (GO:0090073)2.86067691
101retinoic acid metabolic process (GO:0042573)2.85504166
102regulation of vasodilation (GO:0042312)2.85245792
103mesenchymal cell differentiation involved in kidney development (GO:0072161)2.82291882
104mesenchymal cell differentiation involved in renal system development (GO:2001012)2.82291882
105water homeostasis (GO:0030104)2.81156216
106flavonoid metabolic process (GO:0009812)2.80699957
107inorganic anion transmembrane transport (GO:0098661)2.79946838
108positive regulation of interleukin-8 secretion (GO:2000484)2.78508221
109cellular monovalent inorganic cation homeostasis (GO:0030004)2.78272768
110purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.76237002
111ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.76237002
112nucleoside bisphosphate biosynthetic process (GO:0033866)2.76237002
113chloride transmembrane transport (GO:1902476)2.75678028
114mesonephros development (GO:0001823)2.75179095
115positive regulation of guanylate cyclase activity (GO:0031284)2.75176464
116detection of bacterium (GO:0016045)2.74838229
117negative regulation of mast cell activation (GO:0033004)2.73614579
118purinergic nucleotide receptor signaling pathway (GO:0035590)2.72564112
119Leydig cell differentiation (GO:0033327)2.72475951
120O-glycan processing (GO:0016266)2.72298497
121regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70346803
122DNA ligation (GO:0006266)2.70193196
123membrane hyperpolarization (GO:0060081)2.70012009
124oligosaccharide biosynthetic process (GO:0009312)2.69287632
125detection of other organism (GO:0098543)2.68187073
126epoxygenase P450 pathway (GO:0019373)2.67118731
127developmental pigmentation (GO:0048066)2.66750381
128nucleotide transmembrane transport (GO:1901679)2.65983573
129nephron tubule formation (GO:0072079)2.64144556
130sodium ion homeostasis (GO:0055078)2.63917198
131lipoxygenase pathway (GO:0019372)2.63890333
132regulation of development, heterochronic (GO:0040034)2.63322987
133ribonucleoprotein complex disassembly (GO:0032988)2.63208982
134GPI anchor metabolic process (GO:0006505)2.62624384
135preassembly of GPI anchor in ER membrane (GO:0016254)2.62028797
136regulation of pH (GO:0006885)2.61511846
137positive regulation of uterine smooth muscle contraction (GO:0070474)2.60188933
138presynaptic membrane assembly (GO:0097105)2.60144242
139regulation of corticosteroid hormone secretion (GO:2000846)2.59688726
140chloride transport (GO:0006821)2.59102270
141epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58570484
142cyclooxygenase pathway (GO:0019371)2.58156251
143regulation of cilium movement (GO:0003352)2.57235488
144positive regulation of growth hormone secretion (GO:0060124)2.56757430
145glucosamine-containing compound catabolic process (GO:1901072)2.55280337
146regulation of cell proliferation involved in kidney development (GO:1901722)2.53710745
147dendritic cell chemotaxis (GO:0002407)2.51348519
148proteasome assembly (GO:0043248)2.50640197
149chemical homeostasis within a tissue (GO:0048875)2.50557413
150desmosome organization (GO:0002934)2.49984962
151transcription elongation from RNA polymerase III promoter (GO:0006385)2.48736361
152termination of RNA polymerase III transcription (GO:0006386)2.48736361
153T-helper cell differentiation (GO:0042093)2.47249380
154CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.47249380
155mannosylation (GO:0097502)2.45791951
156lymphoid progenitor cell differentiation (GO:0002320)2.45696943
157dendritic cell migration (GO:0036336)2.42616503
158glycosphingolipid catabolic process (GO:0046479)2.42255374
159keratinocyte proliferation (GO:0043616)2.38842368
160photoreceptor cell differentiation (GO:0046530)2.38474713
161eye photoreceptor cell differentiation (GO:0001754)2.38474713
162regulation of pigment cell differentiation (GO:0050932)2.37729028
163serotonin receptor signaling pathway (GO:0007210)2.37016884
164CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.36520788
165T cell differentiation involved in immune response (GO:0002292)2.36276208
166alpha-beta T cell differentiation involved in immune response (GO:0002293)2.36276208
167alpha-beta T cell activation involved in immune response (GO:0002287)2.36276208
168presynaptic membrane organization (GO:0097090)2.36125581
169otic vesicle formation (GO:0030916)2.35984259
170intraciliary transport (GO:0042073)2.35359629
171negative regulation of execution phase of apoptosis (GO:1900118)2.33688475
172positive regulation of T cell migration (GO:2000406)2.31531717
173inner ear receptor stereocilium organization (GO:0060122)2.29430992
174pyrimidine dimer repair (GO:0006290)2.29370486
175DNA damage response, detection of DNA damage (GO:0042769)2.29276474
176respiratory chain complex IV assembly (GO:0008535)2.28406810
177cilium assembly (GO:0042384)2.28170275
178sphingolipid catabolic process (GO:0030149)2.26894477
179motile cilium assembly (GO:0044458)2.25168330
180regulation of nuclear cell cycle DNA replication (GO:0033262)2.24626383
181negative regulation of DNA-dependent DNA replication (GO:2000104)2.22690397
182adenosine metabolic process (GO:0046085)2.22033606
183cell differentiation involved in metanephros development (GO:0072202)2.21644382
184regulation of activation of Janus kinase activity (GO:0010533)2.21458886
185cerebral cortex radially oriented cell migration (GO:0021799)2.19992255
186cilium organization (GO:0044782)2.19575525
187nucleoside diphosphate catabolic process (GO:0009134)2.19344077
188lateral sprouting from an epithelium (GO:0060601)2.19075965
189negative regulation of T cell mediated immunity (GO:0002710)2.18948918
190centriole replication (GO:0007099)2.18817590
191energy homeostasis (GO:0097009)2.18367370
192viral protein processing (GO:0019082)2.18062298
193regulation of T cell migration (GO:2000404)2.16740865
194oligosaccharide catabolic process (GO:0009313)2.16346252
195positive regulation of monocyte chemotaxis (GO:0090026)2.16310535
196positive regulation of microtubule polymerization (GO:0031116)2.16152440
197CD4-positive, alpha-beta T cell activation (GO:0035710)2.15838690
198negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.15554429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.31400334
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.02045962
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75961620
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68398232
5BMI1_23680149_ChIP-Seq_NPCS_Mouse2.68189059
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.61304315
7EZH2_22144423_ChIP-Seq_EOC_Human2.59935546
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49508704
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.49470733
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.48638296
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.40325902
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.39439239
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.34771557
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21522108
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.20112315
16TAF15_26573619_Chip-Seq_HEK293_Human2.14593589
17* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.14103929
18GATA4_25053715_ChIP-Seq_YYC3_Human2.09063050
19* AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.08779055
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.06827001
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.05791987
22SOX2_20726797_ChIP-Seq_SW620_Human2.05616384
23PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04270495
24VDR_22108803_ChIP-Seq_LS180_Human2.03683676
25FOXO3_23340844_ChIP-Seq_DLD1_Human2.01746324
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.99479633
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.98158994
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.96847440
29* FOXA1_25552417_ChIP-Seq_VCAP_Human1.95822763
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95819809
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95486973
32* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.94301283
33EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.86688198
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84174369
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.82713622
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.80239345
37RNF2_27304074_Chip-Seq_NSC_Mouse1.77587264
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.75586782
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75307849
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.74034601
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.72958399
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.69078471
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68369998
44FUS_26573619_Chip-Seq_HEK293_Human1.68178385
45P300_19829295_ChIP-Seq_ESCs_Human1.67886435
46P53_22387025_ChIP-Seq_ESCs_Mouse1.65672124
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65351783
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64746870
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.64332896
50CDX2_22108803_ChIP-Seq_LS180_Human1.63478393
51EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.63271319
52NMYC_18555785_Chip-Seq_ESCs_Mouse1.60669080
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60645835
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.59544332
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.58551399
56RUNX1_27457419_Chip-Seq_LIVER_Mouse1.58078003
57IRF1_19129219_ChIP-ChIP_H3396_Human1.57525623
58P300_18555785_Chip-Seq_ESCs_Mouse1.56290006
59RXR_22108803_ChIP-Seq_LS180_Human1.55741507
60GATA6_25053715_ChIP-Seq_YYC3_Human1.55614894
61ER_23166858_ChIP-Seq_MCF-7_Human1.54764069
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52518378
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51722220
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51254263
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51254263
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.50633799
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.48943205
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47025218
69FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.45797953
70TP63_23658742_ChIP-Seq_EP156T_Human1.45633578
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44888580
72CBP_20019798_ChIP-Seq_JUKART_Human1.44707064
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44707064
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.44113872
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43198454
76EWS_26573619_Chip-Seq_HEK293_Human1.43090363
77ZFX_18555785_Chip-Seq_ESCs_Mouse1.42508197
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42286141
79IGF1R_20145208_ChIP-Seq_DFB_Human1.42136729
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40464048
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.40366505
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.40246039
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39650796
84PU1_27457419_Chip-Seq_LIVER_Mouse1.38681340
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37661391
86* TAL1_26923725_Chip-Seq_HPCs_Mouse1.37398063
87KLF4_18555785_Chip-Seq_ESCs_Mouse1.37192931
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35426395
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34918636
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33562251
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.32863328
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32809319
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.32229521
94HTT_18923047_ChIP-ChIP_STHdh_Human1.30533193
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.30199964
96SMAD1_18555785_Chip-Seq_ESCs_Mouse1.28981330
97SMAD4_21799915_ChIP-Seq_A2780_Human1.28978024
98ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27984798
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27865818
100AHR_22903824_ChIP-Seq_MCF-7_Human1.27473998
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27048474
102CTCF_18555785_Chip-Seq_ESCs_Mouse1.26567739
103STAT3_23295773_ChIP-Seq_U87_Human1.26051183
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25176235
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24940152
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24416748
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.24095363
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23516768
109AR_25329375_ChIP-Seq_VCAP_Human1.23488174
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23166297
111SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22797914
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22673161
113TCF4_22108803_ChIP-Seq_LS180_Human1.22171674
114FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21598025
115TRIM28_21343339_ChIP-Seq_HEK293_Human1.21044181
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20436794
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17993362
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16822681
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.16115930
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14921106
121PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14752290
122TP53_18474530_ChIP-ChIP_U2OS_Human1.14592606
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13542697
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10991074
125CJUN_26792858_Chip-Seq_BT549_Human1.10894595
126OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10590760
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09919701
128EZH2_27294783_Chip-Seq_ESCs_Mouse1.08735293
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08601436
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07154942
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07093376
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05144862
133EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04419870
134RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04419870
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04202651
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03329904
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03329904
138RUNX2_22187159_ChIP-Seq_PCA_Human1.03027923
139TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03018444
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02458479
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02126301
142AR_20517297_ChIP-Seq_VCAP_Human1.01776275
143ESR2_21235772_ChIP-Seq_MCF-7_Human1.01286527
144RNF2_27304074_Chip-Seq_ESCs_Mouse1.00992930
145ARNT_22903824_ChIP-Seq_MCF-7_Human0.98790453
146TP53_16413492_ChIP-PET_HCT116_Human0.98744742
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97554325
148TCF4_23295773_ChIP-Seq_U87_Human0.97410699
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.95602907
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95151066
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.92631544
152LXR_22158963_ChIP-Seq_LIVER_Mouse0.89800532
153BCAT_22108803_ChIP-Seq_LS180_Human0.89740610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.73804668
2MP0003300_gastrointestinal_ulcer4.36592987
3MP0000566_synostosis4.16159914
4MP0003195_calcinosis3.71930944
5MP0004043_abnormal_pH_regulation3.66623119
6MP0004381_abnormal_hair_follicle3.52516093
7MP0003136_yellow_coat_color3.51786869
8MP0006292_abnormal_olfactory_placode3.34837282
9MP0010234_abnormal_vibrissa_follicle3.27251227
10MP0001188_hyperpigmentation3.21139834
11MP0003283_abnormal_digestive_organ3.11701859
12MP0003252_abnormal_bile_duct3.09956149
13MP0003941_abnormal_skin_development2.87877604
14MP0005220_abnormal_exocrine_pancreas2.87002157
15MP0002139_abnormal_hepatobiliary_system2.82024021
16MP0005409_darkened_coat_color2.69946824
17MP0005171_absent_coat_pigmentation2.50042752
18MP0005365_abnormal_bile_salt2.44945799
19MP0003880_abnormal_central_pattern2.40566099
20MP0005085_abnormal_gallbladder_physiolo2.38510299
21MP0001666_abnormal_nutrient_absorption2.35822158
22MP0005360_urolithiasis2.33406787
23MP0000462_abnormal_digestive_system2.30283401
24MP0002277_abnormal_respiratory_mucosa2.21727040
25MP0010386_abnormal_urinary_bladder2.09344761
26MP0006276_abnormal_autonomic_nervous2.07967866
27MP0002928_abnormal_bile_duct1.95059573
28MP0003787_abnormal_imprinting1.93038502
29MP0001664_abnormal_digestion1.92037980
30MP0002796_impaired_skin_barrier1.89525101
31MP0001756_abnormal_urination1.86483244
32MP0002638_abnormal_pupillary_reflex1.82517791
33MP0005451_abnormal_body_composition1.81713848
34MP0002132_abnormal_respiratory_system1.81553308
35MP0005645_abnormal_hypothalamus_physiol1.78645870
36MP0000383_abnormal_hair_follicle1.77776245
37MP0000015_abnormal_ear_pigmentation1.77241343
38MP0003950_abnormal_plasma_membrane1.76237722
39MP0003866_abnormal_defecation1.74193660
40MP0002009_preneoplasia1.72698939
41MP0001986_abnormal_taste_sensitivity1.71844574
42MP0008004_abnormal_stomach_pH1.70060076
43MP0002098_abnormal_vibrissa_morphology1.69399866
44MP0002938_white_spotting1.65229546
45MP0001835_abnormal_antigen_presentation1.62280197
46MP0003183_abnormal_peptide_metabolism1.62041831
47MP0002876_abnormal_thyroid_physiology1.58444828
48MP0002148_abnormal_hypersensitivity_rea1.57878654
49MP0001346_abnormal_lacrimal_gland1.57111319
50MP0000537_abnormal_urethra_morphology1.57053167
51MP0003724_increased_susceptibility_to1.56909173
52MP0004782_abnormal_surfactant_physiolog1.55031805
53MP0005075_abnormal_melanosome_morpholog1.54171236
54MP0002102_abnormal_ear_morphology1.53186092
55MP0000538_abnormal_urinary_bladder1.51758364
56MP0003879_abnormal_hair_cell1.50410429
57MP0008872_abnormal_physiological_respon1.49579379
58MP0004264_abnormal_extraembryonic_tissu1.47282303
59MP0005248_abnormal_Harderian_gland1.46741073
60MP0008995_early_reproductive_senescence1.45241423
61MP0001765_abnormal_ion_homeostasis1.41267217
62MP0000372_irregular_coat_pigmentation1.40486115
63MP0002095_abnormal_skin_pigmentation1.40262161
64MP0003943_abnormal_hepatobiliary_system1.40068535
65MP0009780_abnormal_chondrocyte_physiolo1.39830322
66MP0009379_abnormal_foot_pigmentation1.39823344
67MP0003806_abnormal_nucleotide_metabolis1.32776974
68MP0010352_gastrointestinal_tract_polyps1.32527030
69MP0001905_abnormal_dopamine_level1.30285932
70MP0004019_abnormal_vitamin_homeostasis1.30281636
71MP0004742_abnormal_vestibular_system1.29960568
72MP0001984_abnormal_olfaction1.29881010
73MP0002089_abnormal_postnatal_growth/wei1.29032121
74MP0008057_abnormal_DNA_replication1.27420411
75MP0005501_abnormal_skin_physiology1.25234773
76MP0003045_fibrosis1.23971178
77MP0005646_abnormal_pituitary_gland1.23843717
78MP0009278_abnormal_bone_marrow1.22791350
79MP0001502_abnormal_circadian_rhythm1.20212430
80MP0004145_abnormal_muscle_electrophysio1.19063186
81MP0000613_abnormal_salivary_gland1.17175619
82MP0005174_abnormal_tail_pigmentation1.17142997
83MP0005636_abnormal_mineral_homeostasis1.16199471
84MP0000647_abnormal_sebaceous_gland1.16048293
85MP0003786_premature_aging1.13729793
86MP0001919_abnormal_reproductive_system1.12306212
87MP0002168_other_aberrant_phenotype1.11526498
88MP0005551_abnormal_eye_electrophysiolog1.11515202
89MP0000477_abnormal_intestine_morphology1.10086248
90MP0008058_abnormal_DNA_repair1.07496678
91MP0000026_abnormal_inner_ear1.07393315
92MP0003868_abnormal_feces_composition1.05600342
93MP0005379_endocrine/exocrine_gland_phen1.04856976
94MP0001529_abnormal_vocalization1.04041791
95MP0005671_abnormal_response_to1.02929758
96MP0008875_abnormal_xenobiotic_pharmacok1.02472962
97MP0008877_abnormal_DNA_methylation1.01519888
98MP0005647_abnormal_sex_gland1.01335434
99MP0001486_abnormal_startle_reflex1.00390481
100MP0005332_abnormal_amino_acid1.00325122
101MP0000230_abnormal_systemic_arterial0.96931151
102MP0010771_integument_phenotype0.96335648
103MP0003938_abnormal_ear_development0.96225118
104MP0000762_abnormal_tongue_morphology0.95603962
105MP0010678_abnormal_skin_adnexa0.93291486
106MP0003763_abnormal_thymus_physiology0.92543660
107MP0005253_abnormal_eye_physiology0.90712161
108MP0009697_abnormal_copulation0.89695442
109MP0000013_abnormal_adipose_tissue0.88646371
110MP0005367_renal/urinary_system_phenotyp0.88221413
111MP0000516_abnormal_urinary_system0.88221413
112MP0001216_abnormal_epidermal_layer0.87358437
113MP0002163_abnormal_gland_morphology0.87255092
114MP0001270_distended_abdomen0.87236187
115MP0002557_abnormal_social/conspecific_i0.86597125
116MP0001968_abnormal_touch/_nociception0.85896505
117MP0005423_abnormal_somatic_nervous0.85396821
118MP0003718_maternal_effect0.84807756
119MP0002272_abnormal_nervous_system0.84475234
120MP0002233_abnormal_nose_morphology0.83884422
121MP0004147_increased_porphyrin_level0.83845636
122MP0005310_abnormal_salivary_gland0.83828893
123MP0004133_heterotaxia0.83294395
124MP0009785_altered_susceptibility_to0.83269764
125MP0009643_abnormal_urine_homeostasis0.83062339
126MP0002572_abnormal_emotion/affect_behav0.82537843
127MP0000631_abnormal_neuroendocrine_gland0.82155768
128MP0006035_abnormal_mitochondrial_morpho0.80146112
129MP0009745_abnormal_behavioral_response0.79611242
130MP0005389_reproductive_system_phenotype0.79565611
131MP0002177_abnormal_outer_ear0.79539480
132MP0003011_delayed_dark_adaptation0.79220443
133MP0005084_abnormal_gallbladder_morpholo0.77745373
134MP0001663_abnormal_digestive_system0.77574174
135MP0005000_abnormal_immune_tolerance0.77338931
136MP0005387_immune_system_phenotype0.77098024
137MP0001790_abnormal_immune_system0.77098024
138MP0001186_pigmentation_phenotype0.76767389
139MP0000681_abnormal_thyroid_gland0.76698147
140MP0002735_abnormal_chemical_nociception0.76497370
141MP0004270_analgesia0.76069961
142MP0001963_abnormal_hearing_physiology0.75832800
143MP0001545_abnormal_hematopoietic_system0.75638843
144MP0005397_hematopoietic_system_phenotyp0.75638843
145MP0008007_abnormal_cellular_replicative0.75521209
146MP0002254_reproductive_system_inflammat0.74643538
147MP0004142_abnormal_muscle_tone0.74375962
148MP0001177_atelectasis0.74217307
149MP0000579_abnormal_nail_morphology0.73033329
150MP0002736_abnormal_nociception_after0.72760375
151MP0001501_abnormal_sleep_pattern0.72391092
152MP0001764_abnormal_homeostasis0.71975578
153MP0003937_abnormal_limbs/digits/tail_de0.71391823
154MP0005187_abnormal_penis_morphology0.70354905
155MP0005395_other_phenotype0.70306090
156MP0006072_abnormal_retinal_apoptosis0.70274419
157MP0005381_digestive/alimentary_phenotyp0.70105819
158MP0000470_abnormal_stomach_morphology0.69934683
159MP0004085_abnormal_heartbeat0.69044421
160MP0002060_abnormal_skin_morphology0.68424076
161MP0002249_abnormal_larynx_morphology0.67554674
162MP0002166_altered_tumor_susceptibility0.66675044
163MP0002419_abnormal_innate_immunity0.66236673
164MP0005025_abnormal_response_to0.66205778
165MP0002136_abnormal_kidney_physiology0.65552107
166MP0005410_abnormal_fertilization0.60495306
167MP0001873_stomach_inflammation0.58694298
168MP0002734_abnormal_mechanical_nocicepti0.57157306
169MP0001881_abnormal_mammary_gland0.56608479
170MP0002118_abnormal_lipid_homeostasis0.56323991
171MP0001440_abnormal_grooming_behavior0.54789912
172MP0001944_abnormal_pancreas_morphology0.54647430
173MP0005595_abnormal_vascular_smooth0.54390822
174MP0001970_abnormal_pain_threshold0.53531273
175MP0010155_abnormal_intestine_physiology0.52579164
176MP0000377_abnormal_hair_follicle0.51882640
177MP0003959_abnormal_lean_body0.50969242
178MP0002090_abnormal_vision0.47875950

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of chloride homeostasis (HP:0011422)6.89445992
2Hyperactive renin-angiotensin system (HP:0000841)6.36163893
3Ileus (HP:0002595)6.23375720
4Metabolic alkalosis (HP:0200114)6.00880956
5Male infertility (HP:0003251)4.72715634
6Hyperaldosteronism (HP:0000859)4.56602354
7Azoospermia (HP:0000027)4.45345565
8Abnormality of renin-angiotensin system (HP:0000847)4.42359819
9Decreased circulating renin level (HP:0003351)4.42221563
10Parakeratosis (HP:0001036)4.40959389
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.38201113
12Mitral stenosis (HP:0001718)4.32474238
13Rectal prolapse (HP:0002035)4.25075568
14Exocrine pancreatic insufficiency (HP:0001738)4.01745289
15Flattened epiphyses (HP:0003071)3.99351663
16Vertebral arch anomaly (HP:0008438)3.84427941
17Abnormal biliary tract morphology (HP:0012440)3.72796908
18Abnormal ciliary motility (HP:0012262)3.46991927
19Right ventricular cardiomyopathy (HP:0011663)3.43606624
20Hypokalemic alkalosis (HP:0001949)3.43002488
21Alkalosis (HP:0001948)3.42834056
22Congenital ichthyosiform erythroderma (HP:0007431)3.33670421
23Stomach cancer (HP:0012126)3.29985758
24Abnormality of the nasal septum (HP:0000419)3.27145371
25Small epiphyses (HP:0010585)3.19105194
26Abnormal respiratory motile cilium physiology (HP:0012261)3.13126317
27Barrel-shaped chest (HP:0001552)3.12104265
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.11106239
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10836034
30Renal salt wasting (HP:0000127)3.10096692
31Intrahepatic cholestasis (HP:0001406)3.09450102
32Abnormal spermatogenesis (HP:0008669)3.01101602
33Abnormality of the axillary hair (HP:0100134)3.01048091
34Abnormality of secondary sexual hair (HP:0009888)3.01048091
35Hyponatremia (HP:0002902)3.00075771
36Abnormal respiratory epithelium morphology (HP:0012253)2.97766319
37Abnormal respiratory motile cilium morphology (HP:0005938)2.97766319
38Abnormal hair whorl (HP:0010721)2.97134874
39Hypoplasia of the uterus (HP:0000013)2.96642004
40Tetraparesis (HP:0002273)2.94535011
41Abnormal pancreas size (HP:0012094)2.90865830
42Abnormality of the right ventricle (HP:0001707)2.87543880
43Hypokalemia (HP:0002900)2.85073511
44True hermaphroditism (HP:0010459)2.78188101
45Patchy hypopigmentation of hair (HP:0011365)2.77578012
46Vertebral clefting (HP:0008428)2.73993889
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.73300430
48Absent/shortened dynein arms (HP:0200106)2.73300430
49Duplicated collecting system (HP:0000081)2.72945198
50Abnormality of the renal cortex (HP:0011035)2.69398167
51Dehydration (HP:0001944)2.69325972
52Aplasia cutis congenita (HP:0001057)2.63028869
53Aplasia/hypoplasia of the uterus (HP:0008684)2.59400850
54Arthropathy (HP:0003040)2.58736885
55Hypoplastic labia majora (HP:0000059)2.58262930
56Abnormality of the renal collecting system (HP:0004742)2.57276322
57Insulin-resistant diabetes mellitus (HP:0000831)2.57110452
58Renal tubular acidosis (HP:0001947)2.55121745
59Chromsome breakage (HP:0040012)2.54957924
60Prostate neoplasm (HP:0100787)2.53637306
61Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.52182034
62White forelock (HP:0002211)2.51736813
63Congenital sensorineural hearing impairment (HP:0008527)2.50191537
643-Methylglutaconic aciduria (HP:0003535)2.49606076
65Adrenal overactivity (HP:0002717)2.48900490
66Conical tooth (HP:0000698)2.44329815
67Generalized hypopigmentation of hair (HP:0011358)2.44029006
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.43610185
69Fat malabsorption (HP:0002630)2.42159638
70Erythroderma (HP:0001019)2.37571697
71Ectropion (HP:0000656)2.36369983
72Enlarged kidneys (HP:0000105)2.35355150
73Abnormality of the anterior horn cell (HP:0006802)2.31605632
74Degeneration of anterior horn cells (HP:0002398)2.31605632
75Abnormality of glutamine family amino acid metabolism (HP:0010902)2.31527278
76Medial flaring of the eyebrow (HP:0010747)2.30989329
77Cubitus valgus (HP:0002967)2.30633305
78Tubulointerstitial fibrosis (HP:0005576)2.29677191
79Spinal muscular atrophy (HP:0007269)2.28818296
80Pancreatic fibrosis (HP:0100732)2.28703103
81Abnormality of the labia majora (HP:0012881)2.28366113
82Increased IgM level (HP:0003496)2.26629095
83Chronic hepatic failure (HP:0100626)2.24825906
84Septo-optic dysplasia (HP:0100842)2.23787659
85Abnormality of sodium homeostasis (HP:0010931)2.23231287
86Abnormality of potassium homeostasis (HP:0011042)2.22241110
87Aplasia/hypoplasia of the femur (HP:0005613)2.22089741
88Potter facies (HP:0002009)2.21117228
89Facial shape deformation (HP:0011334)2.21117228
90Short femoral neck (HP:0100864)2.19760350
91Increased circulating renin level (HP:0000848)2.19308589
92Depressed nasal tip (HP:0000437)2.19130053
93Lipid accumulation in hepatocytes (HP:0006561)2.16638831
94Renal Fanconi syndrome (HP:0001994)2.16462244
95Protruding tongue (HP:0010808)2.12565226
96Fair hair (HP:0002286)2.11910638
97Chronic bronchitis (HP:0004469)2.11787258
98Median cleft lip (HP:0000161)2.11154375
99Abnormality of incisor morphology (HP:0011063)2.10279990
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.08499145
101Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.07511195
102Proximal tubulopathy (HP:0000114)2.07271959
103Alveolar cell carcinoma (HP:0006519)2.06951531
104Abnormality of renal resorption (HP:0011038)2.06321812
105Abnormality of molar (HP:0011077)2.05687383
106Abnormality of molar morphology (HP:0011070)2.05687383
107Gout (HP:0001997)2.05338569
108Irregular vertebral endplates (HP:0003301)2.05187777
109Glycosuria (HP:0003076)2.04172593
110Abnormality of urine glucose concentration (HP:0011016)2.04172593
111Cupped ear (HP:0000378)2.03400512
112Preaxial hand polydactyly (HP:0001177)2.03090281
113Abnormal delayed hypersensitivity skin test (HP:0002963)2.02530592
114Occipital encephalocele (HP:0002085)2.02382550
115Abnormality of carpal bone ossification (HP:0006257)2.01775378
116Calf muscle hypertrophy (HP:0008981)2.01716189
117Lip pit (HP:0100267)2.01127353
118Rhinitis (HP:0012384)2.00802593
119Cone-rod dystrophy (HP:0000548)2.00150505
120Abnormality of proline metabolism (HP:0010907)1.96883128
121Hydroxyprolinuria (HP:0003080)1.96883128
122Curly hair (HP:0002212)1.96506356
123Abnormality of the dental pulp (HP:0006479)1.95954993
124Renal tubular dysfunction (HP:0000124)1.93894623
125Nephrogenic diabetes insipidus (HP:0009806)1.93815357
126Abnormality of permanent molar morphology (HP:0011071)1.93651858
127Abnormality of the dental root (HP:0006486)1.93651858
128Taurodontia (HP:0000679)1.93651858
129Short tibia (HP:0005736)1.93431675
130Abnormal hand bone ossification (HP:0010660)1.93246807
131Congenital primary aphakia (HP:0007707)1.93029047
132Renal cortical cysts (HP:0000803)1.92273769
133Bronchiectasis (HP:0002110)1.90210096
134Gait imbalance (HP:0002141)1.90182009
135Wide intermamillary distance (HP:0006610)1.88875826
136Abnormality of the vitamin B12 metabolism (HP:0004341)1.88479453
137Male pseudohermaphroditism (HP:0000037)1.87267549
138Hypothermia (HP:0002045)1.86740672
139Dry hair (HP:0011359)1.85529074
140Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85385805
141Abnormality of midbrain morphology (HP:0002418)1.84150851
142Molar tooth sign on MRI (HP:0002419)1.84150851
143Type I transferrin isoform profile (HP:0003642)1.83749991
144Abnormality of dental color (HP:0011073)1.83546303
145Fibular aplasia (HP:0002990)1.82787965
146Adrenal hypoplasia (HP:0000835)1.82423257
147Optic nerve hypoplasia (HP:0000609)1.82357104
148Abnormality of the septum pellucidum (HP:0007375)1.80044806
149Hypoplasia of the fovea (HP:0007750)1.79490490
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.79490490
151Pancreatic cysts (HP:0001737)1.79375419
152Xerostomia (HP:0000217)1.78525330
153Abnormality of the nasolacrimal system (HP:0000614)1.77357655
154Pheochromocytoma (HP:0002666)1.77028047
155Nasolacrimal duct obstruction (HP:0000579)1.76902500
156Abnormality of the middle phalanges of the toes (HP:0010183)1.76590287
157Lower limb asymmetry (HP:0100559)1.76413309
158Genital tract atresia (HP:0001827)1.76223002
159Vaginal atresia (HP:0000148)1.75721818
160Absent septum pellucidum (HP:0001331)1.74680382
161Febrile seizures (HP:0002373)1.74384360
162Abnormality of the proximal phalanges of the hand (HP:0009834)1.73308294
163Tubulointerstitial nephritis (HP:0001970)1.72883262
164Prolonged neonatal jaundice (HP:0006579)1.72146796
165Aplasia/Hypoplasia of the lens (HP:0008063)1.72019952
166Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71586834
167Corneal erosion (HP:0200020)1.71523530
168Optic neuritis (HP:0100653)1.71466832
169Retrobulbar optic neuritis (HP:0100654)1.71466832
170Hypoplasia of the ulna (HP:0003022)1.71339183
171Abnormality of the preputium (HP:0100587)1.71300629
172Neonatal death (HP:0003811)1.70590247
173Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70073841
174Absent epiphyses (HP:0010577)1.70073841
175Neoplasm of the tracheobronchial system (HP:0100552)1.69811521
176Malnutrition (HP:0004395)1.68485462
177Abnormality of the columella (HP:0009929)1.67988988
178Abnormality of vitamin B metabolism (HP:0004340)1.67660304
179Symphalangism affecting the phalanges of the hand (HP:0009773)1.66928640
180Biliary tract neoplasm (HP:0100574)1.66836478
181Abnormality of vitamin metabolism (HP:0100508)1.66821627
182Steatorrhea (HP:0002570)1.66648949
183Abnormality of the vertebral endplates (HP:0005106)1.66585087
184Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66571858
185Tongue fasciculations (HP:0001308)1.66354968
186Muscle hypertrophy of the lower extremities (HP:0008968)1.65937307
187Thyroid-stimulating hormone excess (HP:0002925)1.65501578
188Pulmonary artery stenosis (HP:0004415)1.65256193
189Aplasia of the phalanges of the hand (HP:0009802)1.64711497
190Obstructive lung disease (HP:0006536)1.63965112
191Chronic obstructive pulmonary disease (HP:0006510)1.63965112
192Stomatitis (HP:0010280)1.63780669
193Erythema (HP:0010783)1.63377101
194Clubbing of toes (HP:0100760)1.62642190
195Nephronophthisis (HP:0000090)1.61501042
196Aganglionic megacolon (HP:0002251)1.61448342
197Congenital, generalized hypertrichosis (HP:0004540)1.60729269
198Atelectasis (HP:0100750)1.60424657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.63475259
2PRKG23.05140378
3TNIK3.03720247
4CASK2.82102751
5STK162.62755928
6ZAK2.60130223
7IRAK42.46982928
8BMPR1B2.37811112
9PASK2.23070859
10ACVR1B2.22893993
11MKNK22.12391717
12LMTK212.8063072
13TXK1.92041688
14MST41.88074878
15BMPR21.87068789
16NEK61.86199549
17FER1.84974051
18MAP3K141.83095070
19MUSK1.82580456
20BRD41.80138626
21INSRR1.75435021
22IRAK21.72099620
23TESK11.70944922
24GRK71.66882562
25SRPK11.63058735
26PLK41.60875075
27EIF2AK21.54507013
28ADRBK21.53370493
29SIK31.47971757
30IRAK11.43306648
31MKNK11.35580740
32MAP3K121.29439298
33BCR1.27721495
34PBK1.26090298
35GRK11.23605179
36MAP2K71.23373729
37NLK1.19330701
38MAP3K21.19140452
39STK241.17803019
40NME21.15854249
41TAOK11.15813607
42AKT31.15046375
43VRK11.13099749
44TRPM71.11095960
45TNK21.11085799
46PINK11.08318209
47FRK1.07198915
48NUAK11.07119756
49CLK11.05952910
50CDK31.05320170
51YES11.04818636
52RIPK41.04095063
53MAPK151.03066044
54TEC1.01381825
55MAPKAPK50.99858723
56RPS6KA40.99681636
57PKN10.96290316
58TGFBR10.96197795
59MAPK130.90861716
60PRPF4B0.90248446
61PRKCE0.87151327
62PIM20.87038694
63DYRK30.86649059
64IKBKE0.84894116
65PDGFRA0.84794839
66STK390.84629764
67GRK50.83867822
68MAPKAPK30.83625959
69IKBKB0.83437514
70WNK40.82797410
71BLK0.79657163
72DYRK1A0.77523416
73ERBB30.76963070
74PLK20.74573437
75EPHA20.72218626
76OXSR10.71525641
77TAF10.70253514
78MET0.69749820
79STK38L0.68802565
80PNCK0.68299839
81TLK10.67943817
82DYRK20.67312488
83EIF2AK30.67190205
84BRAF0.65554578
85LYN0.64097397
86CSNK1A1L0.63073913
87ROCK10.61546816
88MST1R0.61530496
89PDGFRB0.60489007
90STK30.59811645
91NTRK30.59561132
92LIMK10.59072278
93CDC42BPA0.56413187
94TIE10.56381224
95HIPK20.54299838
96NME10.53129450
97ERBB20.52154813
98MARK10.51995206
99PRKAA10.51599494
100EPHB20.51067514
101ITK0.50268863
102SYK0.49803949
103MAPK70.48463360
104BTK0.48203974
105RPS6KA50.46805116
106PRKAA20.46271681
107EPHA30.45913555
108SGK20.45613790
109CSNK1G30.45203166
110NTRK20.45028069
111CAMK2B0.44282379
112CAMK2A0.44239283
113PLK30.44102630
114PRKG10.43758861
115PIK3CA0.43708032
116CHUK0.43615664
117CSNK1G10.43592980
118SGK4940.43425712
119SGK2230.43425712
120PRKACG0.41917502
121CSNK1A10.41097572
122PRKD20.41041721
123ADRBK10.40139344
124FLT30.39734116
125WNK30.38420876
126MAP3K40.38151776
127BUB10.37790334
128PRKCQ0.37579824
129CDK80.37304103
130PRKCA0.37156807
131FGR0.35840796
132MYLK0.35071248
133MAP2K60.34653560
134TAOK20.34278259
135EPHA40.32661627
136CAMK2D0.32604250
137PRKCZ0.29989953
138TTK0.29171240
139PTK60.28071266
140CDK90.26815050
141SGK30.26079085
142PRKACA0.24485945
143GSK3A0.23872906
144DAPK20.22557101
145DAPK10.21259531
146DMPK0.20946409
147ERN10.20437657
148MAP3K70.19551028
149FGFR20.19147492
150MAP3K30.18794780
151MAP3K50.17475002
152PRKD10.17185058
153LATS10.16925121
154PAK30.16146533
155PKN20.15409431
156CSNK1E0.14948112
157ATM0.14187652
158STK380.13841285
159BRSK20.13643804

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.64066547
2Nitrogen metabolism_Homo sapiens_hsa009102.89389580
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.86623044
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.83718394
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60773610
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.52362208
7RNA polymerase_Homo sapiens_hsa030202.38830723
8Sphingolipid metabolism_Homo sapiens_hsa006002.34449967
9Protein export_Homo sapiens_hsa030602.24486563
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23432645
11Sulfur metabolism_Homo sapiens_hsa009202.19396784
12Oxidative phosphorylation_Homo sapiens_hsa001902.13397051
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12288285
14Chemical carcinogenesis_Homo sapiens_hsa052042.08571060
15Bile secretion_Homo sapiens_hsa049762.08522551
16Tyrosine metabolism_Homo sapiens_hsa003502.07203593
17Pancreatic secretion_Homo sapiens_hsa049722.05951823
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94862043
19Arachidonic acid metabolism_Homo sapiens_hsa005901.90867179
20Fanconi anemia pathway_Homo sapiens_hsa034601.88604929
21Nicotine addiction_Homo sapiens_hsa050331.85420959
22Allograft rejection_Homo sapiens_hsa053301.82569033
23Autoimmune thyroid disease_Homo sapiens_hsa053201.79416956
24Proteasome_Homo sapiens_hsa030501.74641588
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72542907
26beta-Alanine metabolism_Homo sapiens_hsa004101.72358225
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71218253
28Homologous recombination_Homo sapiens_hsa034401.69874282
29Starch and sucrose metabolism_Homo sapiens_hsa005001.67486605
30Fat digestion and absorption_Homo sapiens_hsa049751.65917271
31Graft-versus-host disease_Homo sapiens_hsa053321.63545848
32Ether lipid metabolism_Homo sapiens_hsa005651.62135715
33Propanoate metabolism_Homo sapiens_hsa006401.60213268
34Phototransduction_Homo sapiens_hsa047441.56875907
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54806122
36* SNARE interactions in vesicular transport_Homo sapiens_hsa041301.50749718
37Linoleic acid metabolism_Homo sapiens_hsa005911.50394367
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49996274
39Basal transcription factors_Homo sapiens_hsa030221.49771107
40Fatty acid elongation_Homo sapiens_hsa000621.49506682
41Serotonergic synapse_Homo sapiens_hsa047261.48958296
42Ribosome_Homo sapiens_hsa030101.47534354
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47270549
44Primary immunodeficiency_Homo sapiens_hsa053401.46909406
45ABC transporters_Homo sapiens_hsa020101.44806160
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44321751
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.41146525
48Rheumatoid arthritis_Homo sapiens_hsa053231.38006540
49Parkinsons disease_Homo sapiens_hsa050121.37269687
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36959873
51Peroxisome_Homo sapiens_hsa041461.35393937
52Renin-angiotensin system_Homo sapiens_hsa046141.35180252
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.31821276
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30600021
55Non-homologous end-joining_Homo sapiens_hsa034501.29612982
56Alzheimers disease_Homo sapiens_hsa050101.29203983
57Taste transduction_Homo sapiens_hsa047421.26007257
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25676129
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23055856
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.22722515
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20646098
62Huntingtons disease_Homo sapiens_hsa050161.19896560
63Collecting duct acid secretion_Homo sapiens_hsa049661.19341729
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14978456
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13835254
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12006563
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11748686
68Steroid biosynthesis_Homo sapiens_hsa001001.10639119
69Primary bile acid biosynthesis_Homo sapiens_hsa001201.08452457
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08391688
71Fatty acid degradation_Homo sapiens_hsa000711.03444415
72Fatty acid biosynthesis_Homo sapiens_hsa000610.94441216
73Hematopoietic cell lineage_Homo sapiens_hsa046400.93333529
74Butanoate metabolism_Homo sapiens_hsa006500.92775319
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92674771
76Asthma_Homo sapiens_hsa053100.92208869
77Pyrimidine metabolism_Homo sapiens_hsa002400.91127291
78Circadian rhythm_Homo sapiens_hsa047100.90438773
79Tight junction_Homo sapiens_hsa045300.89487957
80Vitamin digestion and absorption_Homo sapiens_hsa049770.89259392
81Fatty acid metabolism_Homo sapiens_hsa012120.89127323
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88367413
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.83850435
84Glutamatergic synapse_Homo sapiens_hsa047240.82041831
85PPAR signaling pathway_Homo sapiens_hsa033200.81362928
86Morphine addiction_Homo sapiens_hsa050320.79819596
87Protein digestion and absorption_Homo sapiens_hsa049740.79555971
88African trypanosomiasis_Homo sapiens_hsa051430.79192382
89Renin secretion_Homo sapiens_hsa049240.77333115
90Long-term depression_Homo sapiens_hsa047300.75285768
91Purine metabolism_Homo sapiens_hsa002300.74897567
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74767029
93Malaria_Homo sapiens_hsa051440.71829497
94Type I diabetes mellitus_Homo sapiens_hsa049400.71343681
95Histidine metabolism_Homo sapiens_hsa003400.71314686
96Measles_Homo sapiens_hsa051620.70909791
97RNA degradation_Homo sapiens_hsa030180.70705651
98Regulation of autophagy_Homo sapiens_hsa041400.68327092
99Phagosome_Homo sapiens_hsa041450.68177222
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66820715
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66161703
102Nucleotide excision repair_Homo sapiens_hsa034200.65932533
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65606418
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64139130
105Spliceosome_Homo sapiens_hsa030400.63906731
106Tryptophan metabolism_Homo sapiens_hsa003800.63553921
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62649794
108GABAergic synapse_Homo sapiens_hsa047270.62028967
109Basal cell carcinoma_Homo sapiens_hsa052170.62026516
110Gastric acid secretion_Homo sapiens_hsa049710.61864206
111Vitamin B6 metabolism_Homo sapiens_hsa007500.61772579
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61037665
113Sulfur relay system_Homo sapiens_hsa041220.60770504
114Retinol metabolism_Homo sapiens_hsa008300.60205975
115Calcium signaling pathway_Homo sapiens_hsa040200.59605615
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56812778
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56806618
118Other glycan degradation_Homo sapiens_hsa005110.56176686
119Circadian entrainment_Homo sapiens_hsa047130.53014075
120Herpes simplex infection_Homo sapiens_hsa051680.52083068
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51939737
122Synaptic vesicle cycle_Homo sapiens_hsa047210.51791359
123Ovarian steroidogenesis_Homo sapiens_hsa049130.51503116
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51252022
125Caffeine metabolism_Homo sapiens_hsa002320.50885742
126Vibrio cholerae infection_Homo sapiens_hsa051100.50816507
127Galactose metabolism_Homo sapiens_hsa000520.50592889
128Pertussis_Homo sapiens_hsa051330.50008209
129Mismatch repair_Homo sapiens_hsa034300.49567858
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48923176
131Axon guidance_Homo sapiens_hsa043600.48655798
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.48111441
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48067714
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47015230
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45693395
136Metabolic pathways_Homo sapiens_hsa011000.44250104
137Hepatitis C_Homo sapiens_hsa051600.43606094
138Amphetamine addiction_Homo sapiens_hsa050310.43258522
139Insulin secretion_Homo sapiens_hsa049110.43000193
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.42766624
141Ras signaling pathway_Homo sapiens_hsa040140.41169572
142T cell receptor signaling pathway_Homo sapiens_hsa046600.40790308
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39823665
144Olfactory transduction_Homo sapiens_hsa047400.39521681
145TGF-beta signaling pathway_Homo sapiens_hsa043500.38537595
146Cocaine addiction_Homo sapiens_hsa050300.38298859
147Chemokine signaling pathway_Homo sapiens_hsa040620.37815031
148N-Glycan biosynthesis_Homo sapiens_hsa005100.37571914
149Wnt signaling pathway_Homo sapiens_hsa043100.37092427
150Thyroid hormone synthesis_Homo sapiens_hsa049180.37088863
151Mineral absorption_Homo sapiens_hsa049780.35915384
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35596843
153Glutathione metabolism_Homo sapiens_hsa004800.34391324
154AMPK signaling pathway_Homo sapiens_hsa041520.34381969
155Fructose and mannose metabolism_Homo sapiens_hsa000510.33145490
156Arginine and proline metabolism_Homo sapiens_hsa003300.32460770
157Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31548465
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.30276991
159Arginine biosynthesis_Homo sapiens_hsa002200.27967850
160Dorso-ventral axis formation_Homo sapiens_hsa043200.26054481
161Salivary secretion_Homo sapiens_hsa049700.24114396
162Glycerolipid metabolism_Homo sapiens_hsa005610.23172462
163Carbon metabolism_Homo sapiens_hsa012000.21488462
164Insulin resistance_Homo sapiens_hsa049310.15889789
165Vascular smooth muscle contraction_Homo sapiens_hsa042700.15469763

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