STX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phototransduction (GO:0007602)8.53831863
2detection of light stimulus (GO:0009583)8.51023943
3positive regulation of guanylate cyclase activity (GO:0031284)8.43793928
4detection of visible light (GO:0009584)8.25419212
5GMP metabolic process (GO:0046037)8.18888370
6phototransduction, visible light (GO:0007603)8.16421328
7regulation of guanylate cyclase activity (GO:0031282)7.81157620
8visual perception (GO:0007601)7.64208894
9sensory perception of light stimulus (GO:0050953)7.60623341
10protein-chromophore linkage (GO:0018298)6.90964140
11cellular response to light stimulus (GO:0071482)6.67021587
12retina development in camera-type eye (GO:0060041)6.05237039
13positive regulation by symbiont of host defense response (GO:0052509)5.89042437
14modulation by symbiont of host defense response (GO:0052031)5.89042437
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.89042437
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.89042437
17positive regulation by organism of defense response of other organism involved in symbiotic interact5.89042437
18modulation by symbiont of host immune response (GO:0052553)5.89042437
19detection of external stimulus (GO:0009581)5.88545845
20detection of abiotic stimulus (GO:0009582)5.79172886
21neutrophil activation involved in immune response (GO:0002283)5.68848174
22photoreceptor cell differentiation (GO:0046530)5.65612328
23eye photoreceptor cell differentiation (GO:0001754)5.65612328
24regulation of cGMP metabolic process (GO:0030823)5.59019463
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.58410887
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.32899848
27response to peptidoglycan (GO:0032494)5.13667745
28positive regulation of cGMP biosynthetic process (GO:0030828)5.11806575
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.04666912
30negative regulation of cell killing (GO:0031342)5.04666912
31detection of molecule of bacterial origin (GO:0032490)5.03573381
32macrophage activation involved in immune response (GO:0002281)4.96599298
33regulation of cGMP biosynthetic process (GO:0030826)4.91972573
34cellular potassium ion homeostasis (GO:0030007)4.89738369
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.81817430
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.68708135
37detection of other organism (GO:0098543)4.66567097
38neutrophil activation (GO:0042119)4.52564837
39positive regulation of gamma-delta T cell activation (GO:0046645)4.52376569
40regulation of interferon-beta biosynthetic process (GO:0045357)4.48379849
41nonmotile primary cilium assembly (GO:0035058)4.44289932
42detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.42553874
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.41646543
44positive regulation of cGMP metabolic process (GO:0030825)4.40758815
45detection of external biotic stimulus (GO:0098581)4.37948506
46cellular response to radiation (GO:0071478)4.36797379
47response to pheromone (GO:0019236)4.34687266
48regulation of voltage-gated calcium channel activity (GO:1901385)4.31159143
49negative regulation of interleukin-12 production (GO:0032695)4.30913895
50respiratory burst (GO:0045730)4.28339196
51granulocyte activation (GO:0036230)4.24045360
52cellular extravasation (GO:0045123)4.17958134
53detection of bacterium (GO:0016045)4.17309120
54antigen processing and presentation of endogenous antigen (GO:0019883)4.13531164
55cell morphogenesis involved in neuron differentiation (GO:0048667)4.12500638
56regulation of clathrin-mediated endocytosis (GO:2000369)4.08566102
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.06926078
58response to host immune response (GO:0052572)4.06926078
59production of molecular mediator involved in inflammatory response (GO:0002532)4.03215390
60receptor guanylyl cyclase signaling pathway (GO:0007168)4.02938384
61regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.99352134
62regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.99352134
63response to histamine (GO:0034776)3.97573516
64macrophage activation (GO:0042116)3.95172959
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.94503661
66behavioral response to ethanol (GO:0048149)3.93994969
67potassium ion homeostasis (GO:0055075)3.88665996
68leukocyte migration involved in inflammatory response (GO:0002523)3.87944853
69detection of biotic stimulus (GO:0009595)3.80023572
70myeloid cell activation involved in immune response (GO:0002275)3.68171757
71response to host (GO:0075136)3.67543500
72response to host defenses (GO:0052200)3.67543500
73response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.67543500
74regulation of B cell receptor signaling pathway (GO:0050855)3.67038378
75sensory perception (GO:0007600)3.66850682
76microglial cell activation (GO:0001774)3.65328707
77neutrophil mediated immunity (GO:0002446)3.64012908
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61546390
79regulation of mast cell degranulation (GO:0043304)3.61486748
80lipopolysaccharide-mediated signaling pathway (GO:0031663)3.58093997
81antigen processing and presentation via MHC class Ib (GO:0002475)3.52791201
82retina homeostasis (GO:0001895)3.52622712
83regulation of leukocyte degranulation (GO:0043300)3.49628003
84response to light stimulus (GO:0009416)3.48180383
85regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.44175642
86immunoglobulin mediated immune response (GO:0016064)3.43321366
87regulation of gamma-delta T cell activation (GO:0046643)3.41529417
88regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.40547876
89regulation of myeloid leukocyte mediated immunity (GO:0002886)3.40006412
90positive regulation of cellular amide metabolic process (GO:0034250)3.39255254
91positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.38396959
92sodium ion export (GO:0071436)3.38354141
93leukocyte aggregation (GO:0070486)3.37168453
94positive regulation of synapse maturation (GO:0090129)3.36675868
95response to interleukin-15 (GO:0070672)3.30759723
96membrane hyperpolarization (GO:0060081)3.30622731
97regulation of mast cell activation involved in immune response (GO:0033006)3.28664110
98neuron development (GO:0048666)3.28371480
99leukocyte degranulation (GO:0043299)3.26672242
100negative regulation of lymphocyte mediated immunity (GO:0002707)3.24542648
101regulation of penile erection (GO:0060405)3.23514574
102positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.23056922
103regulation of short-term neuronal synaptic plasticity (GO:0048172)3.22663729
104negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.22399087
105positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20957770
106protein prenylation (GO:0018342)3.20466393
107prenylation (GO:0097354)3.20466393
108protein localization to synapse (GO:0035418)3.20037249
109negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18781244
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18761206
111positive regulation of toll-like receptor signaling pathway (GO:0034123)3.18270288
112positive regulation of interferon-alpha production (GO:0032727)3.18211969
113negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13202612
114positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12904384
115interferon-gamma secretion (GO:0072643)3.11576333
116regulation of regulated secretory pathway (GO:1903305)3.10756196
117positive regulation of regulated secretory pathway (GO:1903307)3.10320884
118positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.09404542
119positive regulation of Cdc42 GTPase activity (GO:0043089)3.08659690
120dendritic cell migration (GO:0036336)3.04762246
121positive regulation of leukocyte degranulation (GO:0043302)3.01472250
122adaptation of signaling pathway (GO:0023058)3.01128983
123protein heterotetramerization (GO:0051290)3.00918649
124regulation of interferon-alpha production (GO:0032647)3.00346777
125positive regulation of neurotransmitter transport (GO:0051590)2.99905212
126striatum development (GO:0021756)2.96136444
127positive regulation of mast cell activation (GO:0033005)2.96134118
128dendritic cell chemotaxis (GO:0002407)2.95430462
129positive regulation of sodium ion transmembrane transport (GO:1902307)2.94388311
130myeloid leukocyte mediated immunity (GO:0002444)2.93613552
131cellular response to type I interferon (GO:0071357)2.92701876
132type I interferon signaling pathway (GO:0060337)2.92701876
133regulation of mast cell activation (GO:0033003)2.92358963
134peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.92171564
135regulation of gamma-delta T cell differentiation (GO:0045586)2.91776946
136negative regulation of leukocyte mediated immunity (GO:0002704)2.90882098
137response to type I interferon (GO:0034340)2.90306501
138lipoprotein transport (GO:0042953)2.90014196
139cellular response to interleukin-15 (GO:0071350)2.88451494
140icosanoid secretion (GO:0032309)2.88216908
141arachidonic acid secretion (GO:0050482)2.88216908
142regulation of T-helper 2 cell differentiation (GO:0045628)2.88168104
143sensory perception of smell (GO:0007608)2.85046242
144negative regulation of toll-like receptor signaling pathway (GO:0034122)2.84351390
145neutrophil chemotaxis (GO:0030593)2.82323358
146negative regulation of T-helper cell differentiation (GO:0045623)2.82281277
147negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82281277
148positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.81427269
149negative regulation of erythrocyte differentiation (GO:0045647)2.80490592
150detection of chemical stimulus involved in sensory perception (GO:0050907)2.78345580
151myeloid leukocyte activation (GO:0002274)2.77642882
152B cell mediated immunity (GO:0019724)2.77449139
153neutrophil migration (GO:1990266)2.75192461
154germinal center formation (GO:0002467)2.74626138
155positive regulation of interferon-beta production (GO:0032728)2.72560300
156negative regulation of cation channel activity (GO:2001258)2.69658312
157negative regulation of glycoprotein biosynthetic process (GO:0010561)2.69591430
158chemosensory behavior (GO:0007635)2.68444505
159negative regulation of calcium ion transmembrane transport (GO:1903170)2.67567706
160negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.67567706
161positive regulation of mast cell activation involved in immune response (GO:0033008)2.66825447
162positive regulation of mast cell degranulation (GO:0043306)2.66825447
163regulation of toll-like receptor signaling pathway (GO:0034121)2.66812169
164protein localization to endosome (GO:0036010)2.66496473
165synaptic vesicle docking involved in exocytosis (GO:0016081)2.65746416
166regulation of tolerance induction (GO:0002643)2.63221218
167JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62688006
168I-kappaB phosphorylation (GO:0007252)2.62623162
169regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.60604922
170post-embryonic morphogenesis (GO:0009886)2.58910041
171innervation (GO:0060384)2.58394992
172dopamine receptor signaling pathway (GO:0007212)2.58111279
173regulation of neurotransmitter uptake (GO:0051580)2.56029515
174regulation of interleukin-8 biosynthetic process (GO:0045414)2.55120818
175synaptic vesicle maturation (GO:0016188)2.53604690
176synaptic transmission, dopaminergic (GO:0001963)2.52879551
177retina layer formation (GO:0010842)2.52764927
178regulation of synaptic vesicle exocytosis (GO:2000300)2.52731399
179regulation of synapse maturation (GO:0090128)2.52658805
180cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50510601
181short-term memory (GO:0007614)2.49174012
182synaptic vesicle endocytosis (GO:0048488)2.48677718
183behavioral response to cocaine (GO:0048148)2.47883577
184sensory perception of chemical stimulus (GO:0007606)2.47633602
185estrogen biosynthetic process (GO:0006703)2.45606159
186response to radiation (GO:0009314)2.44545281
187synaptic vesicle exocytosis (GO:0016079)2.41257252
188detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.39916484
189regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.38476126
190regulation of synaptic transmission, dopaminergic (GO:0032225)2.32332967
191righting reflex (GO:0060013)2.31535258
192regulation of rhodopsin mediated signaling pathway (GO:0022400)14.5640584
193rhodopsin mediated signaling pathway (GO:0016056)14.3452801
194retinal cone cell development (GO:0046549)13.8235302
195detection of light stimulus involved in sensory perception (GO:0050962)12.1922914
196detection of light stimulus involved in visual perception (GO:0050908)12.1922914
197photoreceptor cell development (GO:0042461)11.0817739
198retinal rod cell development (GO:0046548)10.7772188
199eye photoreceptor cell development (GO:0042462)10.6873349
200photoreceptor cell maintenance (GO:0045494)10.1093095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.56915341
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.29572096
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.25147572
4VDR_22108803_ChIP-Seq_LS180_Human3.93837602
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.80368090
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.28027568
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24010969
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.13872262
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11549379
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.09424586
11HIF1A_21447827_ChIP-Seq_MCF-7_Human3.04119219
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97834393
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.93007970
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.82072085
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.75964590
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.75288046
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65573294
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.59502259
19SPI1_23547873_ChIP-Seq_NB4_Human2.55361687
20SPI1_23127762_ChIP-Seq_K562_Human2.49133874
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.45631385
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.44207339
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40138110
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.38199141
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19674163
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15418480
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08234028
28VDR_24763502_ChIP-Seq_THP-1_Human2.07876684
29P53_22127205_ChIP-Seq_FIBROBLAST_Human2.03116718
30SMAD3_21741376_ChIP-Seq_HESCs_Human1.99886218
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94774947
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.92357476
33GBX2_23144817_ChIP-Seq_PC3_Human1.90661525
34DROSHA_22980978_ChIP-Seq_HELA_Human1.90204102
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87963027
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86619616
37GATA1_22025678_ChIP-Seq_K562_Human1.86360859
38IGF1R_20145208_ChIP-Seq_DFB_Human1.83042978
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.81663585
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80477975
41RUNX_20019798_ChIP-Seq_JUKART_Human1.78088640
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77547165
43SCL_19346495_ChIP-Seq_HPC-7_Human1.77393333
44MYB_26560356_Chip-Seq_TH2_Human1.74795674
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74026572
46VDR_21846776_ChIP-Seq_THP-1_Human1.72354904
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70791543
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70621312
49MAF_26560356_Chip-Seq_TH1_Human1.70564500
50MYB_26560356_Chip-Seq_TH1_Human1.66390439
51* TCF7_22412390_ChIP-Seq_EML_Mouse1.65942824
52REST_21632747_ChIP-Seq_MESCs_Mouse1.65470450
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65220248
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64622207
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64539869
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64539869
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64539869
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60292481
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58770208
60TFEB_21752829_ChIP-Seq_HELA_Human1.57744273
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55870180
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53968690
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.52599230
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.52248167
65* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51787572
66* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.50760756
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49282324
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.49171347
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46453993
70NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46102805
71* GATA2_21666600_ChIP-Seq_HMVEC_Human1.45894811
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.43771548
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43086245
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.43014678
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42485353
76VDR_24787735_ChIP-Seq_THP-1_Human1.41956099
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40912729
78UTX_26944678_Chip-Seq_JUKART_Human1.40487126
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39659607
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39145937
81NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.39114307
82MYC_22102868_ChIP-Seq_BL_Human1.38591275
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37722978
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37414460
85PU_27001747_Chip-Seq_BMDM_Mouse1.36614663
86TBX3_20139965_ChIP-Seq_MESCs_Mouse1.36266522
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35799842
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35711451
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35246407
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34698838
91GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.34291292
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32227970
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31113481
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.30708101
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29651920
96* KAP1_27257070_Chip-Seq_ESCs_Mouse1.29585060
97GATA3_27048872_Chip-Seq_THYMUS_Human1.29531291
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29218469
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28797809
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28523580
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.28061257
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.26339812
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26028560
104* KDM2B_26808549_Chip-Seq_K562_Human1.25674075
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25581753
106* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24571659
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23778392
108GATA1_19941826_ChIP-Seq_K562_Human1.22954533
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.22276134
110GATA2_19941826_ChIP-Seq_K562_Human1.22267244
111NCOR1_26117541_ChIP-Seq_K562_Human1.21888303
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21427102
113SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20931382
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20648126
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19220212
116VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18778328
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18154196
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17953704
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17398537
120AR_19668381_ChIP-Seq_PC3_Human1.17344606
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16398925
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16264981
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15149091
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13922713
125* RACK7_27058665_Chip-Seq_MCF-7_Human1.13789343
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13699049
127* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.13248619
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13115905
129PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12857394
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12523538
131* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12336313
132PHF8_20622854_ChIP-Seq_HELA_Human1.11676383
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11601993
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11348334
135CREB1_26743006_Chip-Seq_LNCaP_Human1.11101883
136CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10780077
137GATA6_25053715_ChIP-Seq_YYC3_Human1.10168761
138* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10124856
139MAF_26560356_Chip-Seq_TH2_Human1.09897787
140* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09152256
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08689190
142NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08585956
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08312541
144ESR2_21235772_ChIP-Seq_MCF-7_Human1.08305648
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07023635
146* KDM2B_26808549_Chip-Seq_DND41_Human1.06753256
147* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06736096
148SMC4_20622854_ChIP-Seq_HELA_Human1.06469669
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06231677
150IRF8_22096565_ChIP-ChIP_GC-B_Human1.05087539
151CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04847034
152ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04720269
153GATA3_26560356_Chip-Seq_TH2_Human1.04515855
154IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03992381
155RXR_22158963_ChIP-Seq_LIVER_Mouse1.02522547
156PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02470122
157ESR1_21235772_ChIP-Seq_MCF-7_Human1.01210538
158LXR_22158963_ChIP-Seq_LIVER_Mouse1.01161000
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00989280
160KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99277759
161YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98382888
162P68_20966046_ChIP-Seq_HELA_Human0.97478467
163SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97168532
164SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97168532
165GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94659357
166GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94335745
167NANOG_16518401_ChIP-PET_MESCs_Mouse0.94244660
168NCOR_22424771_ChIP-Seq_293T_Human0.93456231
169RARB_27405468_Chip-Seq_BRAIN_Mouse0.93209827
170BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91881490
171POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90875436
172YY1_22570637_ChIP-Seq_MALME-3M_Human0.87966433
173* CTCF_27219007_Chip-Seq_Bcells_Human0.87670824
174VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86772290
175TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.86319919
176SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85846482
177SMAD4_21799915_ChIP-Seq_A2780_Human0.85712972
178CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85699846
179POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84889150
180SA1_27219007_Chip-Seq_Bcells_Human0.84745571
181SMAD4_21741376_ChIP-Seq_HESCs_Human0.82166299
182ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81156611
183* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.80570599
184PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80227691
185* RING1B_27294783_Chip-Seq_NPCs_Mouse0.79566123
186DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78337203
187NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78103181
188STAT3_23295773_ChIP-Seq_U87_Human0.77280401
189CTCF_20526341_ChIP-Seq_ESCs_Human0.76794961
190FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.76681052
191SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75723133
192TBL1_22424771_ChIP-Seq_293T_Human0.75633354
193* DPY_21335234_ChIP-Seq_ESCs_Mouse0.75155853
194* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74461919
195EZH2_27294783_Chip-Seq_ESCs_Mouse0.74356555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.46597370
2MP0003011_delayed_dark_adaptation9.08477353
3MP0005253_abnormal_eye_physiology6.66574380
4MP0006072_abnormal_retinal_apoptosis6.56208234
5MP0003724_increased_susceptibility_to4.55854452
6MP0005195_abnormal_posterior_eye3.74757505
7MP0003950_abnormal_plasma_membrane3.71071633
8MP0003303_peritoneal_inflammation3.52435515
9MP0002090_abnormal_vision3.37312929
10MP0003436_decreased_susceptibility_to3.25351124
11MP0005391_vision/eye_phenotype3.20725257
12MP0001324_abnormal_eye_pigmentation3.15770050
13MP0003191_abnormal_cellular_cholesterol3.14078114
14MP0005451_abnormal_body_composition2.96146351
15MP0002638_abnormal_pupillary_reflex2.78173646
16MP0002419_abnormal_innate_immunity2.73463522
17MP0008260_abnormal_autophagy2.67406791
18MP0001835_abnormal_antigen_presentation2.66619369
19MP0001986_abnormal_taste_sensitivity2.66169148
20MP0009785_altered_susceptibility_to2.53592754
21MP0005423_abnormal_somatic_nervous2.50081933
22MP0002229_neurodegeneration2.39595520
23MP0006082_CNS_inflammation2.37500646
24MP0003300_gastrointestinal_ulcer2.36477080
25MP0005025_abnormal_response_to2.26658314
26MP0001984_abnormal_olfaction2.09902703
27MP0005000_abnormal_immune_tolerance2.01760165
28MP0001800_abnormal_humoral_immune1.93260085
29MP0002452_abnormal_antigen_presenting1.92772400
30MP0002148_abnormal_hypersensitivity_rea1.90754533
31MP0002723_abnormal_immune_serum1.90326866
32MP0000685_abnormal_immune_system1.88925511
33MP0001819_abnormal_immune_cell1.88134002
34MP0002420_abnormal_adaptive_immunity1.87760888
35MP0005464_abnormal_platelet_physiology1.86082095
36MP0003828_pulmonary_edema1.85590676
37MP0005387_immune_system_phenotype1.81881524
38MP0001790_abnormal_immune_system1.81881524
39MP0010386_abnormal_urinary_bladder1.81303458
40MP0002752_abnormal_somatic_nervous1.78600878
41MP0002132_abnormal_respiratory_system1.75742356
42MP0001533_abnormal_skeleton_physiology1.69364816
43MP0005671_abnormal_response_to1.68227308
44MP0004947_skin_inflammation1.66849815
45MP0002254_reproductive_system_inflammat1.66169937
46MP0009840_abnormal_foam_cell1.62088773
47MP0006292_abnormal_olfactory_placode1.61673658
48MP0010155_abnormal_intestine_physiology1.59049284
49MP0004782_abnormal_surfactant_physiolog1.55470376
50MP0001845_abnormal_inflammatory_respons1.54644321
51MP0005394_taste/olfaction_phenotype1.48117962
52MP0005499_abnormal_olfactory_system1.48117962
53MP0002405_respiratory_system_inflammati1.47941549
54MP0004019_abnormal_vitamin_homeostasis1.44787080
55MP0000858_altered_metastatic_potential1.39555347
56MP0001764_abnormal_homeostasis1.37197154
57MP0001502_abnormal_circadian_rhythm1.35408492
58MP0000716_abnormal_immune_system1.34990309
59MP0002653_abnormal_ependyma_morphology1.33918578
60MP0002398_abnormal_bone_marrow1.33501051
61MP0008789_abnormal_olfactory_epithelium1.33342335
62MP0004381_abnormal_hair_follicle1.31906728
63MP0000015_abnormal_ear_pigmentation1.29923881
64MP0002396_abnormal_hematopoietic_system1.29604875
65MP0008469_abnormal_protein_level1.29026624
66MP0002998_abnormal_bone_remodeling1.26391185
67MP0009333_abnormal_splenocyte_physiolog1.21385433
68MP0002882_abnormal_neuron_morphology1.21323170
69MP0009278_abnormal_bone_marrow1.20974753
70MP0002332_abnormal_exercise_endurance1.19680409
71MP0003075_altered_response_to1.18225205
72MP0003890_abnormal_embryonic-extraembry1.16602750
73MP0002722_abnormal_immune_system1.14568962
74MP0000689_abnormal_spleen_morphology1.13327564
75MP0002429_abnormal_blood_cell1.12118795
76MP0002877_abnormal_melanocyte_morpholog1.08654798
77MP0003806_abnormal_nucleotide_metabolis1.07451507
78MP0003221_abnormal_cardiomyocyte_apopto1.06130392
79MP0004883_abnormal_blood_vessel1.06115814
80MP0005164_abnormal_response_to1.05800319
81MP0005248_abnormal_Harderian_gland1.02972338
82MP0002166_altered_tumor_susceptibility0.99983765
83MP0004043_abnormal_pH_regulation0.98652140
84MP0005397_hematopoietic_system_phenotyp0.98416599
85MP0001545_abnormal_hematopoietic_system0.98416599
86MP0003763_abnormal_thymus_physiology0.97583897
87MP0004264_abnormal_extraembryonic_tissu0.97066019
88MP0003453_abnormal_keratinocyte_physiol0.96450207
89MP0005197_abnormal_uvea_morphology0.95749162
90MP0004233_abnormal_muscle_weight0.95084120
91MP0001851_eye_inflammation0.94756728
92MP0002127_abnormal_cardiovascular_syste0.92548505
93MP0005075_abnormal_melanosome_morpholog0.92513058
94MP0003566_abnormal_cell_adhesion0.91500113
95MP0003195_calcinosis0.89932992
96MP0003656_abnormal_erythrocyte_physiolo0.89644540
97MP0003448_altered_tumor_morphology0.89052812
98MP0009046_muscle_twitch0.88004305
99MP0002796_impaired_skin_barrier0.87632990
100MP0000490_abnormal_crypts_of0.87557846
101MP0000703_abnormal_thymus_morphology0.86395494
102MP0005166_decreased_susceptibility_to0.84815218
103MP0002139_abnormal_hepatobiliary_system0.83462443
104MP0003690_abnormal_glial_cell0.81423000
105MP0002272_abnormal_nervous_system0.79983144
106MP0005076_abnormal_cell_differentiation0.78997058
107MP0004808_abnormal_hematopoietic_stem0.78871761
108MP0002006_tumorigenesis0.77651101
109MP0001853_heart_inflammation0.76336999
110MP0005319_abnormal_enzyme/_coenzyme0.76279674
111MP0010352_gastrointestinal_tract_polyps0.74913922
112MP0004885_abnormal_endolymph0.73945748
113MP0005408_hypopigmentation0.73395766
114MP0000371_diluted_coat_color0.73182423
115MP0000609_abnormal_liver_physiology0.72953991
116MP0010234_abnormal_vibrissa_follicle0.72323914
117MP0002277_abnormal_respiratory_mucosa0.70830754
118MP0000604_amyloidosis0.70143315
119MP0008004_abnormal_stomach_pH0.69089924
120MP0004510_myositis0.67541085
121MP0003183_abnormal_peptide_metabolism0.67061046
122MP0000569_abnormal_digit_pigmentation0.66925719
123MP0005083_abnormal_biliary_tract0.66811386
124MP0004185_abnormal_adipocyte_glucose0.66810893
125MP0002693_abnormal_pancreas_physiology0.66220467
126MP0000343_altered_response_to0.65070471
127MP0003795_abnormal_bone_structure0.63774901
128MP0005409_darkened_coat_color0.63731493
129MP0005058_abnormal_lysosome_morphology0.61866653
130MP0001346_abnormal_lacrimal_gland0.61123232
131MP0005187_abnormal_penis_morphology0.61057496
132MP0002734_abnormal_mechanical_nocicepti0.59443879
133MP0008058_abnormal_DNA_repair0.59075449
134MP0001486_abnormal_startle_reflex0.57989811
135MP0003634_abnormal_glial_cell0.57485731
136MP0003172_abnormal_lysosome_physiology0.56780668
137MP0001188_hyperpigmentation0.56240386
138MP0005257_abnormal_intraocular_pressure0.55519477
139MP0005310_abnormal_salivary_gland0.54305916
140MP0003879_abnormal_hair_cell0.53415799
141MP0001286_abnormal_eye_development0.52460894
142MP0001293_anophthalmia0.49929123
143MP0004145_abnormal_muscle_electrophysio0.49719528
144MP0002697_abnormal_eye_size0.48038423
145MP0002067_abnormal_sensory_capabilities0.46442327
146MP0008775_abnormal_heart_ventricle0.46405854
147MP0002909_abnormal_adrenal_gland0.46328861
148MP0005595_abnormal_vascular_smooth0.46051227
149MP0002064_seizures0.42234463
150MP0003045_fibrosis0.42167892
151MP0010030_abnormal_orbit_morphology0.40928730
152MP0000631_abnormal_neuroendocrine_gland0.39486795
153MP0004270_analgesia0.38737058
154MP0003941_abnormal_skin_development0.38696776
155MP0004215_abnormal_myocardial_fiber0.37315863
156MP0003635_abnormal_synaptic_transmissio0.37081884
157MP0002138_abnormal_hepatobiliary_system0.35325203
158MP0002184_abnormal_innervation0.35260164
159MP0003880_abnormal_central_pattern0.32237831
160MP0003866_abnormal_defecation0.31915404
161MP0004133_heterotaxia0.31120534
162MP0001963_abnormal_hearing_physiology0.30357728
163MP0000465_gastrointestinal_hemorrhage0.28639523
164MP0005376_homeostasis/metabolism_phenot0.28410100
165MP0003283_abnormal_digestive_organ0.27329361
166MP0008961_abnormal_basal_metabolism0.27083958
167MP0003943_abnormal_hepatobiliary_system0.24735472
168MP0008007_abnormal_cellular_replicative0.23819732
169MP0003111_abnormal_nucleus_morphology0.23432635
170MP0003638_abnormal_response/metabolism_0.22568832
171MP0002063_abnormal_learning/memory/cond0.22540458
172MP0001501_abnormal_sleep_pattern0.22475008
173MP0000350_abnormal_cell_proliferation0.21794190
174MP0003693_abnormal_embryo_hatching0.21545193
175MP0002572_abnormal_emotion/affect_behav0.21328414
176MP0005670_abnormal_white_adipose0.21029500
177MP0002822_catalepsy0.20569168
178MP0004811_abnormal_neuron_physiology0.20345779
179MP0009764_decreased_sensitivity_to0.19705398
180MP0004858_abnormal_nervous_system0.19683922
181MP0005367_renal/urinary_system_phenotyp0.19521912
182MP0000516_abnormal_urinary_system0.19521912
183MP0000470_abnormal_stomach_morphology0.19255947
184MP0005220_abnormal_exocrine_pancreas0.18863754

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.93058859
2Abnormal rod and cone electroretinograms (HP:0008323)9.76857617
3Absent rod-and cone-mediated responses on ERG (HP:0007688)9.59534561
4Pigmentary retinal degeneration (HP:0001146)8.29749703
5Central scotoma (HP:0000603)8.10259868
6Abnormality of macular pigmentation (HP:0008002)7.53196342
7Pendular nystagmus (HP:0012043)6.94536017
8Dyschromatopsia (HP:0007641)6.87861367
9Decreased central vision (HP:0007663)6.83214006
10Chorioretinal atrophy (HP:0000533)6.81423796
11Attenuation of retinal blood vessels (HP:0007843)6.75100145
12Scotoma (HP:0000575)6.74917708
13Eczematoid dermatitis (HP:0000976)6.24461815
14Abolished electroretinogram (ERG) (HP:0000550)5.72204246
15Severe visual impairment (HP:0001141)5.60544868
16Recurrent abscess formation (HP:0002722)5.58299661
17Recurrent bacterial skin infections (HP:0005406)5.47935810
18Photophobia (HP:0000613)5.22604905
19Type II diabetes mellitus (HP:0005978)5.17238317
20Orchitis (HP:0100796)5.09803652
21Increased corneal curvature (HP:0100692)5.08177982
22Keratoconus (HP:0000563)5.08177982
23Myositis (HP:0100614)4.94594210
24Optic neuritis (HP:0100653)4.72217583
25Retrobulbar optic neuritis (HP:0100654)4.72217583
26Macular degeneration (HP:0000608)4.61155204
27Cone-rod dystrophy (HP:0000548)4.21455410
28Choroideremia (HP:0001139)4.08774423
29Posterior subcapsular cataract (HP:0007787)4.04639978
30Recurrent gram-negative bacterial infections (HP:0005420)4.03249704
31Retinitis pigmentosa (HP:0000510)3.88218945
32Constricted visual fields (HP:0001133)3.82152824
33Stomatitis (HP:0010280)3.81518563
34Vitreoretinal degeneration (HP:0000655)3.79834700
35Gastrointestinal infarctions (HP:0005244)3.57677512
36Chronic obstructive pulmonary disease (HP:0006510)3.42407119
37Obstructive lung disease (HP:0006536)3.42407119
38Keratoconjunctivitis sicca (HP:0001097)3.41755640
39Abnormality of liposaccharide metabolism (HP:0010968)3.29145510
40Abnormality of glycosphingolipid metabolism (HP:0004343)3.29145510
41Abnormality of glycolipid metabolism (HP:0010969)3.29145510
42Recurrent skin infections (HP:0001581)3.26865522
43Recurrent fungal infections (HP:0002841)3.24773488
44Progressive visual loss (HP:0000529)3.21000507
45Mediastinal lymphadenopathy (HP:0100721)3.20745785
46Keratoconjunctivitis (HP:0001096)3.12640694
47Urticaria (HP:0001025)3.04075017
48Elevated erythrocyte sedimentation rate (HP:0003565)3.00820756
49Decreased electroretinogram (ERG) amplitude (HP:0000654)3.00492753
50Spontaneous hematomas (HP:0007420)2.91609374
51Gingival bleeding (HP:0000225)2.86631231
52Episodic fever (HP:0001954)2.85349439
53Arterial thrombosis (HP:0004420)2.84938770
54Amyloidosis (HP:0011034)2.80457681
55Anorexia (HP:0002039)2.78235785
56Congenital sensorineural hearing impairment (HP:0008527)2.76452370
57Vacuolated lymphocytes (HP:0001922)2.74546254
58Meningitis (HP:0001287)2.70684551
59Loss of speech (HP:0002371)2.69070292
60Hypochromic microcytic anemia (HP:0004840)2.62925233
61Osteomyelitis (HP:0002754)2.60123604
62Encephalitis (HP:0002383)2.58856974
63Subacute progressive viral hepatitis (HP:0006572)2.58184331
64Vasculitis (HP:0002633)2.56582954
65T lymphocytopenia (HP:0005403)2.56446653
66Hemoptysis (HP:0002105)2.54274540
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50168279
68Increased IgE level (HP:0003212)2.49935753
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.48911928
70Subcapsular cataract (HP:0000523)2.47719894
71Abnormality of T cell number (HP:0011839)2.46073868
72Chest pain (HP:0100749)2.44545113
73Malnutrition (HP:0004395)2.43804167
74Petechiae (HP:0000967)2.43503438
75Prolonged bleeding time (HP:0003010)2.37260433
76Chronic mucocutaneous candidiasis (HP:0002728)2.35353805
77Recurrent cutaneous fungal infections (HP:0011370)2.35353805
78Retinal atrophy (HP:0001105)2.34965355
79Congenital primary aphakia (HP:0007707)2.31341475
80Pulmonary infiltrates (HP:0002113)2.30852565
81Cellulitis (HP:0100658)2.29186854
82Hypochromic anemia (HP:0001931)2.27872216
83Gait imbalance (HP:0002141)2.27667210
84Myocardial infarction (HP:0001658)2.27029799
85Peritonitis (HP:0002586)2.27005132
86Dysostosis multiplex (HP:0000943)2.22841145
87Pulmonary embolism (HP:0002204)2.20559925
88Wide nasal bridge (HP:0000431)2.19867552
89Disinhibition (HP:0000734)2.18869537
90Epistaxis (HP:0000421)2.18416529
91Acne (HP:0001061)2.15736920
92Leukocytosis (HP:0001974)2.15669534
93Aplasia/Hypoplasia of the fovea (HP:0008060)2.14220865
94Hypoplasia of the fovea (HP:0007750)2.14220865
95Nephrogenic diabetes insipidus (HP:0009806)2.12721590
96Increased CSF protein (HP:0002922)2.12028558
97Increased serum ferritin (HP:0003281)2.08272411
98Cheilitis (HP:0100825)2.07593922
99Pustule (HP:0200039)2.06502099
100Slow saccadic eye movements (HP:0000514)2.04984039
101Progressive neurologic deterioration (HP:0002344)2.03048016
102Abnormality of iron homeostasis (HP:0011031)2.03036627
103Segmental peripheral demyelination/remyelination (HP:0003481)2.00933953
104Premature loss of primary teeth (HP:0006323)2.00904416
105Congenital stationary night blindness (HP:0007642)17.4124271
106Septo-optic dysplasia (HP:0100842)1.99519539
107Polycythemia (HP:0001901)1.99331548
108Optic disc pallor (HP:0000543)1.99272053
109Acute hepatic failure (HP:0006554)1.96564755
110Medial flaring of the eyebrow (HP:0010747)1.95798819
111Hepatosplenomegaly (HP:0001433)1.95565341
112Pathologic fracture (HP:0002756)1.95502393
113Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95004815
114Abnormality of polysaccharide metabolism (HP:0011012)1.95004815
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95004815
116True hermaphroditism (HP:0010459)1.94847703
117Autoimmune thrombocytopenia (HP:0001973)1.92755283
118Interstitial pulmonary disease (HP:0006530)1.91377620
119Micronodular cirrhosis (HP:0001413)1.90028788
120Gangrene (HP:0100758)1.89973185
121Recurrent viral infections (HP:0004429)1.88896050
122Poor coordination (HP:0002370)1.88650021
123Mucopolysacchariduria (HP:0008155)1.87152610
124Urinary glycosaminoglycan excretion (HP:0003541)1.87152610
125Hematochezia (HP:0002573)1.86137583
126Periodontitis (HP:0000704)1.83394411
127Microcytic anemia (HP:0001935)1.82876664
128Abnormality of the fovea (HP:0000493)1.82066719
129Abnormality of transition element cation homeostasis (HP:0011030)1.81611702
130Abnormality of the endocardium (HP:0004306)1.81501437
131Curly hair (HP:0002212)1.80195251
132Abnormality of T cells (HP:0002843)1.79270809
133Keratitis (HP:0000491)1.75520053
134Inflammation of the large intestine (HP:0002037)1.75113132
135Metaphyseal cupping (HP:0003021)1.74997024
136Abnormality of the pleura (HP:0002103)1.73711047
137Skin ulcer (HP:0200042)1.70631352
138Aplasia/Hypoplasia of the macula (HP:0008059)1.66993267
139Febrile seizures (HP:0002373)1.59815244
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.55293758
141Pancreatic fibrosis (HP:0100732)1.51057401
142Optic atrophy (HP:0000648)1.50999500
143Aplasia/Hypoplasia affecting the retina (HP:0008061)1.50472372
144Vaginal atresia (HP:0000148)1.50146256
145Horizontal nystagmus (HP:0000666)1.48262909
146Genital tract atresia (HP:0001827)1.43794707
147Epileptic encephalopathy (HP:0200134)1.40453194
148Albinism (HP:0001022)1.36322757
149Pancreatic cysts (HP:0001737)1.34692100
150Abdominal situs inversus (HP:0003363)1.32409872
151Abnormality of abdominal situs (HP:0011620)1.32409872
152Severe Myopia (HP:0011003)1.29860949
153Increased cerebral lipofuscin (HP:0011813)1.27371363
154Dysdiadochokinesis (HP:0002075)1.26040667
155Astigmatism (HP:0000483)1.25313815
156Progressive cerebellar ataxia (HP:0002073)1.24966417
157Increased neuronal autofluorescent lipopigment (HP:0002074)1.24073175
158Aplasia/Hypoplasia of the lens (HP:0008063)1.23373417
159Cystic liver disease (HP:0006706)1.22934081
160Polar cataract (HP:0010696)1.20094452
161Absence seizures (HP:0002121)1.18948187
162Decreased testicular size (HP:0008734)1.15408709
163Chorioretinal coloboma (HP:0000567)1.13935161
164Cerebellar dysplasia (HP:0007033)1.13552134
165Visual hallucinations (HP:0002367)1.06581920
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.05342340
167Broad foot (HP:0001769)1.04657425
168Abnormal sex determination (HP:0012244)1.01980639
169Sex reversal (HP:0012245)1.01980639
170Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.01563691
171Dialeptic seizures (HP:0011146)0.98492744
172Osteomalacia (HP:0002749)0.98099746
173Specific learning disability (HP:0001328)0.93596596
174Prolonged QT interval (HP:0001657)0.92649472
175Asthma (HP:0002099)0.88344385
176Ependymoma (HP:0002888)0.87756724
177Abnormality of macrophages (HP:0004311)0.87386462
178Truncal ataxia (HP:0002078)0.87019797
179Optic nerve hypoplasia (HP:0000609)0.84530324
180Hyperactive renin-angiotensin system (HP:0000841)0.84051931
181Agnosia (HP:0010524)0.81359405
182Sclerocornea (HP:0000647)0.80970072
183Abnormality of dental color (HP:0011073)0.80911800
184Left ventricular hypertrophy (HP:0001712)0.79180281
185Abnormality of the astrocytes (HP:0100707)0.79128605
186Astrocytoma (HP:0009592)0.79128605
187Cholecystitis (HP:0001082)0.78657159
188Abnormal gallbladder physiology (HP:0012438)0.78657159
189Generalized hypopigmentation (HP:0007513)0.77535786
190Gingivitis (HP:0000230)0.77502229
191Mutism (HP:0002300)0.76714329
192Hypermetropia (HP:0000540)0.76077309
193Hemiparesis (HP:0001269)0.76000934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK8.57340737
2GRK17.20226949
3NEK13.36560289
4IRAK43.22782681
5MAP2K33.10168445
6CSK2.75670528
7BLK2.71150731
8MST1R2.63865344
9TYK22.40933224
10MAP3K32.35897674
11EPHB12.11540089
12SCYL22.09455034
13AKT32.08392881
14EPHA22.08282810
15ZAP702.00987353
16TAOK11.99195147
17STK381.96694081
18INSRR1.93741433
19MAP4K11.92601568
20RPS6KA41.86278759
21PINK11.84033425
22IRAK21.82561894
23FGR1.76360662
24CDK121.75242782
25GRK61.72467966
26RIPK11.72098645
27IRAK31.69557847
28FES1.66977867
29STK38L1.64149420
30TAOK31.60517138
31NEK21.60012147
32JAK31.55602186
33PTK61.49425575
34CCNB11.40670196
35CDK31.40609792
36HCK1.39241101
37RPS6KB21.35856021
38SIK31.35711950
39MAP3K21.30054683
40TAOK21.29320740
41JAK21.28043670
42CAMK1D1.27336636
43TNK21.23971681
44STK241.22952771
45BMPR21.18833594
46MAP3K131.18736960
47TTK1.16965647
48TBK11.16249019
49BTK1.14293001
50BRD41.09242516
51KSR11.06959374
52PRKD21.03583315
53IKBKE1.03369090
54NME11.01581849
55PRPF4B0.99509319
56ACVR1B0.99490872
57LYN0.96559685
58HIPK20.93791645
59SGK2230.93384609
60SGK4940.93384609
61FGFR40.93272391
62STK100.92590435
63FGFR30.92549661
64MST40.89358060
65MAP3K100.88589671
66SMG10.87468622
67MAP3K120.86288873
68ADRBK10.85880514
69MAP2K60.85242671
70JAK10.85088959
71PAK40.82939650
72SYK0.82491165
73FER0.82445731
74CAMK2D0.82075788
75LRRK20.81152942
76TXK0.80703319
77MARK30.80298554
78PRKAA10.80178617
79PDPK10.79741106
80LCK0.78505051
81TESK20.78290754
82MAPK70.78236471
83CAMK1G0.78008946
84PRKCZ0.77833751
85MAP3K50.76697125
86YES10.76585027
87MET0.74496092
88TRIB30.74196416
89DYRK30.73822212
90ERBB20.71800770
91MARK20.70354407
92PDK10.69528854
93SGK20.69445974
94CHEK20.68869527
95PRKG20.67874723
96RAF10.67651297
97DAPK20.67209721
98TGFBR20.65979712
99ERBB30.63982394
100PLK30.63972274
101ITK0.63627778
102MAP2K40.63292641
103DYRK1A0.61575532
104MAP3K80.60839394
105RIPK40.59401713
106RET0.58784380
107IRAK10.57329318
108TEC0.55260216
109PTK2B0.55217633
110AKT20.54948130
111CDK90.54140416
112CAMKK10.53559883
113CSNK1D0.52924240
114BMX0.51607328
115IKBKB0.51276858
116PNCK0.49474471
117LATS10.48614057
118OXSR10.48400964
119GRK50.48207060
120RPS6KA50.48006085
121CLK10.47995900
122MATK0.47735354
123ATR0.47081567
124PHKG20.47041176
125PHKG10.47041176
126CSF1R0.47020982
127CHUK0.46554474
128PRKAA20.46539530
129DYRK1B0.44912386
130PLK10.44208971
131SGK30.44011392
132CAMK10.43953197
133TRPM70.43748122
134PKN20.42816135
135ALK0.42330455
136MAP3K110.41785520
137MAPK100.41409633
138SIK20.41109737
139PIM10.40303721
140FRK0.40110147
141PRKCI0.39934387
142PRKCB0.39245380
143STK110.39138561
144PIK3CA0.38964439
145FYN0.38799593
146CAMKK20.38773909
147NLK0.38222182
148PRKDC0.38199522
149SGK10.38173958
150EPHA30.38124923
151RPS6KA30.36746622
152MAP3K90.36081809
153PRKCA0.35773910
154KSR20.35578857
155GSK3B0.35312826
156MAPK140.35055352
157PAK60.33941936
158ICK0.33552225
159ATM0.33194613
160MAP3K60.32809293
161PRKACG0.32280621
162MARK10.31894735
163CSNK1E0.31701252
164MAP3K10.30795029
165MAP3K140.30688840
166ERN10.30498871
167NTRK30.29771829
168DAPK10.28492930
169MAP3K40.27951545
170MINK10.27813981
171WNK10.26203677
172CDK70.25514133

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.82253574
2Leishmaniasis_Homo sapiens_hsa051402.69325620
3* Synaptic vesicle cycle_Homo sapiens_hsa047212.28592902
4Staphylococcus aureus infection_Homo sapiens_hsa051502.28239302
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.09185232
6Phototransduction_Homo sapiens_hsa0474413.9957650
7B cell receptor signaling pathway_Homo sapiens_hsa046621.93547474
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.90985124
9GABAergic synapse_Homo sapiens_hsa047271.83445390
10Olfactory transduction_Homo sapiens_hsa047401.72966539
11Acute myeloid leukemia_Homo sapiens_hsa052211.68803213
12Measles_Homo sapiens_hsa051621.61765140
13Malaria_Homo sapiens_hsa051441.60500171
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.57334445
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55651526
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.52340365
17Hepatitis C_Homo sapiens_hsa051601.48048020
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43237865
19Nicotine addiction_Homo sapiens_hsa050331.38008967
20Toxoplasmosis_Homo sapiens_hsa051451.36190814
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35759667
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35472659
23Morphine addiction_Homo sapiens_hsa050321.34540013
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30498726
25Circadian rhythm_Homo sapiens_hsa047101.29281012
26Shigellosis_Homo sapiens_hsa051311.27993706
27African trypanosomiasis_Homo sapiens_hsa051431.24879719
28Salmonella infection_Homo sapiens_hsa051321.24605094
29Fructose and mannose metabolism_Homo sapiens_hsa000511.23548785
30Non-small cell lung cancer_Homo sapiens_hsa052231.23194162
31T cell receptor signaling pathway_Homo sapiens_hsa046601.21174569
32Graft-versus-host disease_Homo sapiens_hsa053321.19723821
33Renal cell carcinoma_Homo sapiens_hsa052111.17244730
34Chronic myeloid leukemia_Homo sapiens_hsa052201.16761741
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.15840805
36VEGF signaling pathway_Homo sapiens_hsa043701.15134409
37Pancreatic cancer_Homo sapiens_hsa052121.14747817
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14445633
39Herpes simplex infection_Homo sapiens_hsa051681.14296960
40Allograft rejection_Homo sapiens_hsa053301.12506414
41Hepatitis B_Homo sapiens_hsa051611.12310149
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11371027
43Hematopoietic cell lineage_Homo sapiens_hsa046401.10764694
44Apoptosis_Homo sapiens_hsa042101.09284837
45Insulin secretion_Homo sapiens_hsa049111.08077842
46Circadian entrainment_Homo sapiens_hsa047131.06257487
47Cholinergic synapse_Homo sapiens_hsa047251.05905206
48Mineral absorption_Homo sapiens_hsa049781.04523618
49Antigen processing and presentation_Homo sapiens_hsa046121.03431378
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.02527193
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99877746
52Endocytosis_Homo sapiens_hsa041440.99602706
53Sphingolipid signaling pathway_Homo sapiens_hsa040710.99519528
54Prolactin signaling pathway_Homo sapiens_hsa049170.98426422
55Thyroid cancer_Homo sapiens_hsa052160.97860364
56Autoimmune thyroid disease_Homo sapiens_hsa053200.96688566
57Galactose metabolism_Homo sapiens_hsa000520.95120017
58Platelet activation_Homo sapiens_hsa046110.93973375
59Collecting duct acid secretion_Homo sapiens_hsa049660.93503983
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91234860
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89369732
62Pertussis_Homo sapiens_hsa051330.89138107
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88765495
64Dopaminergic synapse_Homo sapiens_hsa047280.87931584
65Serotonergic synapse_Homo sapiens_hsa047260.87615841
66Glutamatergic synapse_Homo sapiens_hsa047240.87191655
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84246169
68Endometrial cancer_Homo sapiens_hsa052130.83332393
69Dorso-ventral axis formation_Homo sapiens_hsa043200.82876206
70FoxO signaling pathway_Homo sapiens_hsa040680.82396968
71Regulation of autophagy_Homo sapiens_hsa041400.78972984
72Amoebiasis_Homo sapiens_hsa051460.76058513
73Insulin resistance_Homo sapiens_hsa049310.75706926
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75474064
75Viral myocarditis_Homo sapiens_hsa054160.73458005
76Type II diabetes mellitus_Homo sapiens_hsa049300.73045300
77mTOR signaling pathway_Homo sapiens_hsa041500.72404191
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.72384651
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71637368
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70166349
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69483540
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.68505434
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68374924
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68132032
85Bladder cancer_Homo sapiens_hsa052190.67965166
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.67676619
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66574446
88Inositol phosphate metabolism_Homo sapiens_hsa005620.65468570
89Vibrio cholerae infection_Homo sapiens_hsa051100.65436067
90Salivary secretion_Homo sapiens_hsa049700.64849544
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64478346
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63173147
93Prostate cancer_Homo sapiens_hsa052150.62153822
94ErbB signaling pathway_Homo sapiens_hsa040120.60486565
95Viral carcinogenesis_Homo sapiens_hsa052030.58432071
96Notch signaling pathway_Homo sapiens_hsa043300.55864542
97Insulin signaling pathway_Homo sapiens_hsa049100.55839104
98Purine metabolism_Homo sapiens_hsa002300.54955635
99HIF-1 signaling pathway_Homo sapiens_hsa040660.54855022
100Lysosome_Homo sapiens_hsa041420.54497489
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54123597
102Renin secretion_Homo sapiens_hsa049240.53947842
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49087699
104Oxytocin signaling pathway_Homo sapiens_hsa049210.48987212
105Taste transduction_Homo sapiens_hsa047420.48631225
106* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46811346
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46433115
108Retinol metabolism_Homo sapiens_hsa008300.45979671
109Vitamin digestion and absorption_Homo sapiens_hsa049770.45322910
110Rap1 signaling pathway_Homo sapiens_hsa040150.44907420
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43970339
112Epstein-Barr virus infection_Homo sapiens_hsa051690.43337513
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.43252838
114Alcoholism_Homo sapiens_hsa050340.40819036
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40175070
116Pancreatic secretion_Homo sapiens_hsa049720.39798759
117Primary immunodeficiency_Homo sapiens_hsa053400.39382478
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39366909
119Rheumatoid arthritis_Homo sapiens_hsa053230.37370304
120cAMP signaling pathway_Homo sapiens_hsa040240.34662522
121Biosynthesis of amino acids_Homo sapiens_hsa012300.32769560
122ABC transporters_Homo sapiens_hsa020100.32210247
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30959541
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30798181
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30783760
126Cocaine addiction_Homo sapiens_hsa050300.30193666
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28417022
128mRNA surveillance pathway_Homo sapiens_hsa030150.27996284
129Dilated cardiomyopathy_Homo sapiens_hsa054140.26135534
130Legionellosis_Homo sapiens_hsa051340.25993180
131Thyroid hormone synthesis_Homo sapiens_hsa049180.25649194
132Tight junction_Homo sapiens_hsa045300.25380396
133Gastric acid secretion_Homo sapiens_hsa049710.25133103
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25032697
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25007982
136Chemokine signaling pathway_Homo sapiens_hsa040620.24921851
137Calcium signaling pathway_Homo sapiens_hsa040200.23048082
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22942901
139Sphingolipid metabolism_Homo sapiens_hsa006000.21028668
140Long-term potentiation_Homo sapiens_hsa047200.20433942
141Gap junction_Homo sapiens_hsa045400.20302652
142Phagosome_Homo sapiens_hsa041450.20222601
143GnRH signaling pathway_Homo sapiens_hsa049120.19856228
144Influenza A_Homo sapiens_hsa051640.19255810
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18997460
146Type I diabetes mellitus_Homo sapiens_hsa049400.17844217
147Hippo signaling pathway_Homo sapiens_hsa043900.16567497
148Amphetamine addiction_Homo sapiens_hsa050310.16534327
149Base excision repair_Homo sapiens_hsa034100.16158532
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15846186
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.15516812
152Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14991528
153Choline metabolism in cancer_Homo sapiens_hsa052310.14673747
154Folate biosynthesis_Homo sapiens_hsa007900.14411967
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.14070245
156Other glycan degradation_Homo sapiens_hsa005110.13967216
157Tuberculosis_Homo sapiens_hsa051520.13956914
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12998809
159Adherens junction_Homo sapiens_hsa045200.12944291
160Cardiac muscle contraction_Homo sapiens_hsa042600.11638683
161TNF signaling pathway_Homo sapiens_hsa046680.11514517
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.11331492
163Bile secretion_Homo sapiens_hsa049760.11320886
164RNA degradation_Homo sapiens_hsa030180.10915544
165Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10582782
166NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10521658
167Pentose phosphate pathway_Homo sapiens_hsa000300.10505142
168Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10306612
169MAPK signaling pathway_Homo sapiens_hsa040100.10211207

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