STX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)4.80291189
2negative regulation of interleukin-12 production (GO:0032695)4.72733826
3neutrophil activation involved in immune response (GO:0002283)4.05356876
4lipopolysaccharide-mediated signaling pathway (GO:0031663)4.01129391
5macrophage activation involved in immune response (GO:0002281)3.84723229
6immunoglobulin mediated immune response (GO:0016064)3.80551497
7NIK/NF-kappaB signaling (GO:0038061)3.67453214
8regulation of vitamin D biosynthetic process (GO:0060556)3.66532295
9positive regulation of gamma-delta T cell activation (GO:0046645)3.59930372
10negative regulation of cell killing (GO:0031342)3.56714217
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56714217
12T-helper 1 type immune response (GO:0042088)3.54258674
13positive regulation of chemokine biosynthetic process (GO:0045080)3.47403628
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.42556611
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.42556611
16modulation by symbiont of host immune response (GO:0052553)3.42556611
17positive regulation by symbiont of host defense response (GO:0052509)3.42556611
18modulation by symbiont of host defense response (GO:0052031)3.42556611
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.42556611
20myeloid dendritic cell differentiation (GO:0043011)3.39948088
21negative regulation of cytokine production involved in immune response (GO:0002719)3.38705395
22glycosphingolipid catabolic process (GO:0046479)3.38141911
23type I interferon signaling pathway (GO:0060337)3.31908147
24cellular response to type I interferon (GO:0071357)3.31908147
25positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.31843375
26interferon-gamma-mediated signaling pathway (GO:0060333)3.30109148
27response to type I interferon (GO:0034340)3.29016832
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28442536
29positive regulation of antigen processing and presentation (GO:0002579)3.27896992
30regulation of mononuclear cell migration (GO:0071675)3.27384753
31regulation of chemokine biosynthetic process (GO:0045073)3.25340468
32regulation of cytokine secretion involved in immune response (GO:0002739)3.24648586
33regulation of podosome assembly (GO:0071801)3.19887633
34response to muramyl dipeptide (GO:0032495)3.17887573
35germinal center formation (GO:0002467)3.17809351
36regulation of antigen processing and presentation (GO:0002577)3.13228019
37negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.12463260
38myeloid dendritic cell activation (GO:0001773)3.11130351
39detection of other organism (GO:0098543)3.10843319
40regulation of interferon-beta biosynthetic process (GO:0045357)3.06675708
41granulocyte activation (GO:0036230)3.05540249
42response to protozoan (GO:0001562)3.03566020
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.03506574
44detection of molecule of bacterial origin (GO:0032490)3.02237402
45glycolipid catabolic process (GO:0019377)3.01950474
46regulation of T-helper 1 cell differentiation (GO:0045625)3.01499011
47negative regulation of erythrocyte differentiation (GO:0045647)3.00082099
48cellular response to thyroid hormone stimulus (GO:0097067)2.99335940
49regulation of vitamin metabolic process (GO:0030656)2.99189487
50detection of bacterium (GO:0016045)2.99135719
51oligosaccharide catabolic process (GO:0009313)2.97182529
52amino sugar catabolic process (GO:0046348)2.96660503
53regulation of T-helper 2 cell differentiation (GO:0045628)2.95710051
54regulation of mast cell degranulation (GO:0043304)2.93613327
55adhesion of symbiont to host cell (GO:0044650)2.91994262
56virion attachment to host cell (GO:0019062)2.91994262
57regulation of T cell tolerance induction (GO:0002664)2.91707869
58defense response to protozoan (GO:0042832)2.91017700
59antigen processing and presentation of endogenous antigen (GO:0019883)2.90447499
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90368961
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90099579
62regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89657813
63detection of external biotic stimulus (GO:0098581)2.89580932
64regulation of membrane protein ectodomain proteolysis (GO:0051043)2.88624868
65negative regulation of nitric oxide biosynthetic process (GO:0045019)2.88250687
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85132030
67myeloid cell activation involved in immune response (GO:0002275)2.83371997
68regulation of interferon-alpha production (GO:0032647)2.81052882
69positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.76847485
70positive regulation of heat generation (GO:0031652)2.76554615
71regulation of leukocyte degranulation (GO:0043300)2.71561354
72dendritic cell differentiation (GO:0097028)2.71403027
73positive regulation of NF-kappaB import into nucleus (GO:0042346)2.69160277
74adhesion of symbiont to host (GO:0044406)2.69075934
75macrophage activation (GO:0042116)2.66907681
76ceramide catabolic process (GO:0046514)2.66907393
77B cell mediated immunity (GO:0019724)2.66013566
78regulation of tolerance induction (GO:0002643)2.65297486
79negative regulation of myeloid cell apoptotic process (GO:0033033)2.64581188
80cellular response to interferon-gamma (GO:0071346)2.63904804
81detection of biotic stimulus (GO:0009595)2.63581258
82monocyte chemotaxis (GO:0002548)2.63512531
83cellular response to lipopolysaccharide (GO:0071222)2.62999349
84regulation of type I interferon-mediated signaling pathway (GO:0060338)2.62982708
85neutrophil activation (GO:0042119)2.62466766
86negative regulation of production of molecular mediator of immune response (GO:0002701)2.62426668
87regulation of mast cell activation involved in immune response (GO:0033006)2.60784016
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60432021
89regulation of type 2 immune response (GO:0002828)2.59849379
90positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59822493
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.59373080
92regulation of interleukin-12 production (GO:0032655)2.59305261
93positive regulation of type 2 immune response (GO:0002830)2.57848069
94pinocytosis (GO:0006907)2.57542505
95leukocyte aggregation (GO:0070486)2.56673822
96mannose metabolic process (GO:0006013)2.56584777
97cellular response to molecule of bacterial origin (GO:0071219)2.55127132
98regulation of gamma-delta T cell activation (GO:0046643)2.53854448
99positive regulation of cellular amide metabolic process (GO:0034250)2.52946664
100regulation of fever generation (GO:0031620)2.52267791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.43959837
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.83937577
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.44325386
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.28377806
5VDR_21846776_ChIP-Seq_THP-1_Human2.78220484
6* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.77274140
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76319614
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.65390444
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54375709
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.45829864
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40374612
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38747494
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34609373
14VDR_24763502_ChIP-Seq_THP-1_Human2.31419672
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22167406
16LXR_22292898_ChIP-Seq_THP-1_Human2.17171523
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16623306
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.13136723
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12727126
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04360919
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.03905722
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03700477
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99679174
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91809859
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91660773
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87333631
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83494823
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83184938
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80452114
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77618037
31SPI1_23127762_ChIP-Seq_K562_Human1.74997514
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74797352
33MAF_26560356_Chip-Seq_TH1_Human1.69483955
34MYC_22102868_ChIP-Seq_BL_Human1.69367130
35KDM2B_26808549_Chip-Seq_DND41_Human1.69352173
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.67152848
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66344062
38SPI1_23547873_ChIP-Seq_NB4_Human1.66189490
39TCF7_22412390_ChIP-Seq_EML_Mouse1.65264037
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63486898
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62195671
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53561600
43VDR_24787735_ChIP-Seq_THP-1_Human1.51665925
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46836788
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.44148093
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43221436
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42765601
48PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42331604
49RACK7_27058665_Chip-Seq_MCF-7_Human1.42158596
50UTX_26944678_Chip-Seq_JUKART_Human1.40997998
51SCL_19346495_ChIP-Seq_HPC-7_Human1.39185666
52RUNX_20019798_ChIP-Seq_JUKART_Human1.37937673
53MAF_26560356_Chip-Seq_TH2_Human1.37769760
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33142149
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32502475
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31144132
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28274576
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28163650
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26658598
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25427605
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.24134816
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22403470
63BCL6_27268052_Chip-Seq_Bcells_Human1.21516031
64BCOR_27268052_Chip-Seq_Bcells_Human1.21429458
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19289521
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19002739
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18916763
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15852930
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15328477
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14833335
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14055327
72KDM2B_26808549_Chip-Seq_K562_Human1.13593749
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13162927
74PU_27001747_Chip-Seq_BMDM_Mouse1.13076281
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11898391
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11769626
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.11439546
78GATA1_19941826_ChIP-Seq_K562_Human1.11338505
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.09888596
80GATA1_22025678_ChIP-Seq_K562_Human1.09641852
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09331955
82NCOR1_26117541_ChIP-Seq_K562_Human1.09314987
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08565244
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08205734
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07874178
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.07776168
87MYB_26560356_Chip-Seq_TH2_Human1.06972060
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06575500
89MYB_26560356_Chip-Seq_TH1_Human1.05519673
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05366659
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03823883
92* P68_20966046_ChIP-Seq_HELA_Human1.02262385
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.01685036
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01489829
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01374563
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.99740801
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98905929
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98281464
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96257255
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95323942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.32328507
2MP0005058_abnormal_lysosome_morphology4.04286135
3MP0003436_decreased_susceptibility_to3.57008713
4MP0009840_abnormal_foam_cell3.16675670
5MP0003724_increased_susceptibility_to3.13456791
6MP0006082_CNS_inflammation3.11509638
7MP0002148_abnormal_hypersensitivity_rea2.91582684
8MP0001835_abnormal_antigen_presentation2.81783776
9MP0009785_altered_susceptibility_to2.80472706
10MP0004510_myositis2.65920943
11MP0002419_abnormal_innate_immunity2.58710099
12MP0005000_abnormal_immune_tolerance2.47385333
13MP0005387_immune_system_phenotype2.42994633
14MP0001790_abnormal_immune_system2.42994633
15MP0003172_abnormal_lysosome_physiology2.42551903
16MP0005671_abnormal_response_to2.42499160
17MP0005025_abnormal_response_to2.39805249
18MP0003300_gastrointestinal_ulcer2.34099898
19MP0005451_abnormal_body_composition2.29988360
20MP0003191_abnormal_cellular_cholesterol2.20572098
21MP0002139_abnormal_hepatobiliary_system2.16284280
22MP0001533_abnormal_skeleton_physiology2.10739922
23MP0000685_abnormal_immune_system2.05845816
24MP0002452_abnormal_antigen_presenting2.04502696
25MP0000343_altered_response_to2.03229414
26MP0002723_abnormal_immune_serum2.01907637
27MP0001800_abnormal_humoral_immune2.00620391
28MP0003075_altered_response_to1.97564453
29MP0009764_decreased_sensitivity_to1.93652556
30MP0004947_skin_inflammation1.90249143
31MP0009278_abnormal_bone_marrow1.83866591
32MP0002420_abnormal_adaptive_immunity1.75785452
33MP0001819_abnormal_immune_cell1.75087140
34MP0002998_abnormal_bone_remodeling1.72842170
35MP0000604_amyloidosis1.72797081
36MP0001853_heart_inflammation1.64552656
37MP0010155_abnormal_intestine_physiology1.63438930
38MP0001845_abnormal_inflammatory_respons1.62158076
39MP0009333_abnormal_splenocyte_physiolog1.61047732
40MP0000858_altered_metastatic_potential1.58826488
41MP0002405_respiratory_system_inflammati1.57612790
42MP0003453_abnormal_keratinocyte_physiol1.57566022
43MP0005464_abnormal_platelet_physiology1.55378736
44MP0008469_abnormal_protein_level1.54432869
45MP0003806_abnormal_nucleotide_metabolis1.51311485
46MP0003705_abnormal_hypodermis_morpholog1.45316801
47MP0003448_altered_tumor_morphology1.45001375
48MP0008004_abnormal_stomach_pH1.40296665
49MP0005167_abnormal_blood-brain_barrier1.40047086
50MP0005397_hematopoietic_system_phenotyp1.37864141
51MP0001545_abnormal_hematopoietic_system1.37864141
52MP0008260_abnormal_autophagy1.31834846
53MP0005166_decreased_susceptibility_to1.31027260
54MP0003690_abnormal_glial_cell1.27499674
55MP0000716_abnormal_immune_system1.25125437
56MP0002254_reproductive_system_inflammat1.20694475
57MP0006054_spinal_hemorrhage1.13083745
58MP0005310_abnormal_salivary_gland1.10684752
59MP0002138_abnormal_hepatobiliary_system1.06886420
60MP0001542_abnormal_bone_strength1.05251509
61MP0002398_abnormal_bone_marrow1.05067494
62MP0003828_pulmonary_edema1.04786836
63MP0005390_skeleton_phenotype1.03979140
64MP0002332_abnormal_exercise_endurance1.03919558
65MP0005164_abnormal_response_to1.02962933
66MP0003279_aneurysm0.99443626
67MP0003091_abnormal_cell_migration0.99352338
68MP0003656_abnormal_erythrocyte_physiolo0.98655907
69MP0002933_joint_inflammation0.98416139
70MP0003763_abnormal_thymus_physiology0.97726252
71MP0005023_abnormal_wound_healing0.96929044
72MP0002429_abnormal_blood_cell0.96860721
73MP0003329_amyloid_beta_deposits0.93016481
74MP0000920_abnormal_myelination0.91789842
75MP0000249_abnormal_blood_vessel0.87495847
76MP0000689_abnormal_spleen_morphology0.87427558
77MP0004883_abnormal_blood_vessel0.86102664
78MP0009763_increased_sensitivity_to0.85105975
79MP0001663_abnormal_digestive_system0.84348417
80MP0003795_abnormal_bone_structure0.84044461
81MP0002277_abnormal_respiratory_mucosa0.82739697
82MP0002722_abnormal_immune_system0.81403514
83MP0005165_increased_susceptibility_to0.80848115
84MP0005365_abnormal_bile_salt0.77545425
85MP0008874_decreased_physiological_sensi0.76658763
86MP0001851_eye_inflammation0.75009737
87MP0001873_stomach_inflammation0.74038488
88MP0003879_abnormal_hair_cell0.73853840
89MP0005076_abnormal_cell_differentiation0.70215443
90MP0005319_abnormal_enzyme/_coenzyme0.69120589
91MP0002877_abnormal_melanocyte_morpholog0.68612997
92MP0005595_abnormal_vascular_smooth0.66191276
93MP0001849_ear_inflammation0.64133263
94MP0000465_gastrointestinal_hemorrhage0.64036009
95MP0003183_abnormal_peptide_metabolism0.63012888
96MP0000609_abnormal_liver_physiology0.61969845
97MP0009765_abnormal_xenobiotic_induced0.60737473
98MP0004808_abnormal_hematopoietic_stem0.59810749
99MP0003634_abnormal_glial_cell0.58510662
100MP0001958_emphysema0.57057163

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.25768672
2Abnormality of liposaccharide metabolism (HP:0010968)6.25768672
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.25768672
4Increased cerebral lipofuscin (HP:0011813)4.81712360
5Vacuolated lymphocytes (HP:0001922)4.77215227
6Systemic lupus erythematosus (HP:0002725)4.67922590
7Abnormality of macrophages (HP:0004311)4.66925652
8Dysostosis multiplex (HP:0000943)4.47118647
9Eczematoid dermatitis (HP:0000976)4.21660745
10Loss of speech (HP:0002371)4.15513110
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.13755849
12Recurrent bacterial skin infections (HP:0005406)3.81803555
13Recurrent abscess formation (HP:0002722)3.81268784
14Orchitis (HP:0100796)3.68728562
15Myositis (HP:0100614)3.64772888
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.42551541
17Abnormality of polysaccharide metabolism (HP:0011012)3.42551541
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.42551541
19Retrobulbar optic neuritis (HP:0100654)3.39782263
20Optic neuritis (HP:0100653)3.39782263
21Disinhibition (HP:0000734)3.33011189
22Urinary glycosaminoglycan excretion (HP:0003541)3.24671342
23Mucopolysacchariduria (HP:0008155)3.24671342
24Axonal loss (HP:0003447)3.23613649
25Recurrent gram-negative bacterial infections (HP:0005420)3.21958320
26Mediastinal lymphadenopathy (HP:0100721)3.18428816
27Stomatitis (HP:0010280)3.17399821
28Neurofibrillary tangles (HP:0002185)3.00665212
29Nuclear cataract (HP:0100018)2.99079457
30Glomerulonephritis (HP:0000099)2.98543639
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.94202431
32Increased serum ferritin (HP:0003281)2.87366884
33Amyloidosis (HP:0011034)2.85162199
34Autoimmune thrombocytopenia (HP:0001973)2.82719276
35Mutism (HP:0002300)2.81998063
36Obstructive lung disease (HP:0006536)2.72737441
37Chronic obstructive pulmonary disease (HP:0006510)2.72737441
38Elevated erythrocyte sedimentation rate (HP:0003565)2.66047472
39Purpura (HP:0000979)2.62376030
40Pulmonary infiltrates (HP:0002113)2.57794955
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52440214
42Complement deficiency (HP:0004431)2.47354025
43Myocardial infarction (HP:0001658)2.39168838
44Vasculitis (HP:0002633)2.35663993
45Increased IgE level (HP:0003212)2.33977658
46Keratoconjunctivitis sicca (HP:0001097)2.33616413
47Recurrent skin infections (HP:0001581)2.33182122
48Abnormality of complement system (HP:0005339)2.31155362
49Neuronal loss in central nervous system (HP:0002529)2.31003079
50Hepatosplenomegaly (HP:0001433)2.30284919
51Asymmetric septal hypertrophy (HP:0001670)2.29108376
52Abnormality of iron homeostasis (HP:0011031)2.27063532
53Cellulitis (HP:0100658)2.26411337
54Gingivitis (HP:0000230)2.23994671
55Cerebral inclusion bodies (HP:0100314)2.23015867
56Diminished motivation (HP:0000745)2.21826517
57Petechiae (HP:0000967)2.21502090
58Meningitis (HP:0001287)2.21101982
59Upper motor neuron abnormality (HP:0002127)2.20795307
60Vertebral compression fractures (HP:0002953)2.18370289
61Apathy (HP:0000741)2.17805642
62Progressive neurologic deterioration (HP:0002344)2.17672627
63Malnutrition (HP:0004395)2.15782448
64Recurrent fungal infections (HP:0002841)2.15659059
65Spontaneous hematomas (HP:0007420)2.15194544
66Gangrene (HP:0100758)2.13725458
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12696151
68Interstitial pulmonary disease (HP:0006530)2.11524879
69Hemoptysis (HP:0002105)2.11322767
70Gastrointestinal infarctions (HP:0005244)2.10398325
71Keratoconjunctivitis (HP:0001096)2.03818313
72Urticaria (HP:0001025)2.03722122
73J-shaped sella turcica (HP:0002680)1.99868435
74Pustule (HP:0200039)1.99411124
75Prolonged neonatal jaundice (HP:0006579)1.99030771
76Increased IgM level (HP:0003496)1.98173978
77Gastrointestinal stroma tumor (HP:0100723)1.97806101
78Recurrent viral infections (HP:0004429)1.96100887
79Hematochezia (HP:0002573)1.92411997
80Dementia (HP:0000726)1.92326691
81Polyneuropathy (HP:0001271)1.91123203
82Restrictive lung disease (HP:0002091)1.90928078
83Segmental peripheral demyelination/remyelination (HP:0003481)1.90018239
84Hypergammaglobulinemia (HP:0010702)1.85891580
85Personality changes (HP:0000751)1.85774881
86Colitis (HP:0002583)1.83683839
87Epistaxis (HP:0000421)1.81761640
88Bone pain (HP:0002653)1.81108112
89Abnormality of transition element cation homeostasis (HP:0011030)1.80963691
90Encephalitis (HP:0002383)1.80640422
91Abnormality of the nasal mucosa (HP:0000433)1.80574587
92Spondylolisthesis (HP:0003302)1.79817927
93Pathologic fracture (HP:0002756)1.78058918
94Nephritis (HP:0000123)1.77541539
95Joint stiffness (HP:0001387)1.76505445
96Abnormality of the pleura (HP:0002103)1.76269258
97Emphysema (HP:0002097)1.74527524
98Arthralgia (HP:0002829)1.73894149
99Supranuclear gaze palsy (HP:0000605)1.73776024
100Thin bony cortex (HP:0002753)1.73497991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.28377872
2TAOK23.20706989
3NME23.00102676
4RIPK42.79447238
5ERN12.70464227
6MAP4K12.60625614
7MAP3K142.56989731
8TBK12.51734692
9PRPF4B2.37522806
10TYK22.25853677
11MAP2K32.25461920
12MAP3K112.21295777
13BLK2.16065674
14RIPK12.11948266
15IRAK42.09812255
16MAP3K31.97846385
17GRK71.95955411
18DDR21.87509360
19TAOK11.86009009
20CSK1.81505786
21TRIB31.78375497
22IKBKB1.72055467
23TGFBR21.71833433
24IKBKE1.70779686
25MATK1.57934664
26ZAP701.56111226
27JAK31.55088375
28CDC42BPA1.52805487
29FGR1.52675574
30TXK1.41516744
31PIM21.35171754
32SIK11.32915335
33MAP3K131.29880139
34MOS1.27973273
35MAP3K11.23952527
36MAP2K61.12037580
37CSF1R1.09707607
38CHUK1.08932725
39ABL21.04811445
40BMPR20.99615832
41JAK10.99025970
42FES0.93078247
43TESK20.89174517
44IRAK10.88308953
45TNK20.87506212
46LYN0.87247736
47EPHB10.85732482
48SYK0.85568359
49KIT0.85381965
50IRAK20.84284733
51MAP3K50.81826699
52TAOK30.81182042
53TESK10.80455879
54SIK30.80127892
55TTN0.79519343
56TYRO30.74913696
57CAMKK20.74579689
58HCK0.74258655
59PRKD20.72828686
60BTK0.71774219
61JAK20.70294198
62MAPK70.70112237
63PDGFRA0.68497124
64LCK0.66258101
65MARK20.65789079
66PDPK10.64587495
67MARK30.63444917
68ARAF0.62723805
69MAPK110.61156103
70GRK60.60620759
71FGFR40.60232391
72SMG10.59847561
73RPS6KC10.56557286
74RPS6KL10.56557286
75HIPK20.55859156
76BMX0.54695050
77MAPK120.54627196
78PAK40.54366043
79MAPKAPK30.53965275
80PTK60.53695301
81STK100.53526281
82SIK20.53313434
83MAPK40.49742030
84ADRBK20.49258593
85DYRK1B0.46017689
86PDK10.45999072
87RPS6KA60.44746099
88ICK0.44082800
89NEK90.42699646
90RPS6KA20.41461031
91DAPK30.41316325
92CDK60.39688284
93MAPKAPK20.38807792
94PRKG20.38597718
95MAP3K80.37994829
96CAMKK10.36847277
97KSR20.35873954
98DAPK20.33756154
99PDGFRB0.33673671
100PIM10.32912045

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.47842175
2Staphylococcus aureus infection_Homo sapiens_hsa051502.82547790
3Osteoclast differentiation_Homo sapiens_hsa043802.78564391
4Leishmaniasis_Homo sapiens_hsa051402.65491590
5Lysosome_Homo sapiens_hsa041422.58165489
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.51745569
7Allograft rejection_Homo sapiens_hsa053302.47845059
8Graft-versus-host disease_Homo sapiens_hsa053322.31611628
9Rheumatoid arthritis_Homo sapiens_hsa053232.30836427
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.18688387
11Asthma_Homo sapiens_hsa053102.18103559
12Malaria_Homo sapiens_hsa051442.14100469
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.11735560
14Autoimmune thyroid disease_Homo sapiens_hsa053202.08723300
15Tuberculosis_Homo sapiens_hsa051522.00967291
16TNF signaling pathway_Homo sapiens_hsa046681.98343054
17Pertussis_Homo sapiens_hsa051331.98005324
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94447025
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94446361
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.81849633
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74698119
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72136956
23Toxoplasmosis_Homo sapiens_hsa051451.64998355
24Type I diabetes mellitus_Homo sapiens_hsa049401.60666663
25Legionellosis_Homo sapiens_hsa051341.60123055
26Antigen processing and presentation_Homo sapiens_hsa046121.60062091
27B cell receptor signaling pathway_Homo sapiens_hsa046621.58044525
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55080721
29Salmonella infection_Homo sapiens_hsa051321.54172358
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53783043
31Influenza A_Homo sapiens_hsa051641.49726496
32Phagosome_Homo sapiens_hsa041451.45207424
33Hematopoietic cell lineage_Homo sapiens_hsa046401.36159798
34Viral myocarditis_Homo sapiens_hsa054161.34700238
35Prion diseases_Homo sapiens_hsa050201.31753637
36African trypanosomiasis_Homo sapiens_hsa051431.31114669
37Acute myeloid leukemia_Homo sapiens_hsa052211.29355553
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28120778
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20250415
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20189675
41Herpes simplex infection_Homo sapiens_hsa051681.14647973
42Hepatitis C_Homo sapiens_hsa051601.13462489
43Measles_Homo sapiens_hsa051621.12199256
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10292122
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05866409
46Chemokine signaling pathway_Homo sapiens_hsa040621.05496523
47Bladder cancer_Homo sapiens_hsa052191.05123166
48Shigellosis_Homo sapiens_hsa051311.03089887
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02204931
50Complement and coagulation cascades_Homo sapiens_hsa046101.01129425
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99480297
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95790369
53Amoebiasis_Homo sapiens_hsa051460.94960511
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.94424000
55Apoptosis_Homo sapiens_hsa042100.93711965
56Hepatitis B_Homo sapiens_hsa051610.92653765
57T cell receptor signaling pathway_Homo sapiens_hsa046600.92429923
58Primary immunodeficiency_Homo sapiens_hsa053400.92059046
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.90073213
60VEGF signaling pathway_Homo sapiens_hsa043700.87875665
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75492863
62Collecting duct acid secretion_Homo sapiens_hsa049660.71889073
63Epstein-Barr virus infection_Homo sapiens_hsa051690.71818152
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.69648024
65Sphingolipid metabolism_Homo sapiens_hsa006000.69498281
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68057458
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.61127278
68Notch signaling pathway_Homo sapiens_hsa043300.60822296
69PPAR signaling pathway_Homo sapiens_hsa033200.60057578
70Prolactin signaling pathway_Homo sapiens_hsa049170.59564105
71Galactose metabolism_Homo sapiens_hsa000520.59366016
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.58122315
73Chronic myeloid leukemia_Homo sapiens_hsa052200.55754558
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52756384
75Endocytosis_Homo sapiens_hsa041440.49235023
76* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46714821
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46504503
78HTLV-I infection_Homo sapiens_hsa051660.44797651
79Fructose and mannose metabolism_Homo sapiens_hsa000510.44356455
80Vibrio cholerae infection_Homo sapiens_hsa051100.43756775
81Pancreatic cancer_Homo sapiens_hsa052120.43474060
82Mineral absorption_Homo sapiens_hsa049780.42261052
83HIF-1 signaling pathway_Homo sapiens_hsa040660.41251840
84GnRH signaling pathway_Homo sapiens_hsa049120.40677170
85Insulin resistance_Homo sapiens_hsa049310.39364149
86Platelet activation_Homo sapiens_hsa046110.39181342
87Renal cell carcinoma_Homo sapiens_hsa052110.37785353
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.37513148
89Viral carcinogenesis_Homo sapiens_hsa052030.34453770
90MAPK signaling pathway_Homo sapiens_hsa040100.32416348
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29255364
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25584069
93mTOR signaling pathway_Homo sapiens_hsa041500.23794488
94Non-small cell lung cancer_Homo sapiens_hsa052230.22951879
95Type II diabetes mellitus_Homo sapiens_hsa049300.22043941
96FoxO signaling pathway_Homo sapiens_hsa040680.19000279
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18208809
98Proteoglycans in cancer_Homo sapiens_hsa052050.18154306
99Renin-angiotensin system_Homo sapiens_hsa046140.16063875
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14585433

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