STX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)4.07239743
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.79157714
3negative regulation of cell killing (GO:0031342)3.79157714
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.74281866
5positive regulation by organism of defense response of other organism involved in symbiotic interact3.74281866
6modulation by symbiont of host immune response (GO:0052553)3.74281866
7positive regulation by symbiont of host defense response (GO:0052509)3.74281866
8modulation by symbiont of host defense response (GO:0052031)3.74281866
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.74281866
10negative regulation of erythrocyte differentiation (GO:0045647)3.70927272
11response to muramyl dipeptide (GO:0032495)3.60297571
12negative regulation of interleukin-12 production (GO:0032695)3.53982780
13macrophage activation involved in immune response (GO:0002281)3.47699475
14lipopolysaccharide-mediated signaling pathway (GO:0031663)3.43897710
15positive regulation of gamma-delta T cell activation (GO:0046645)3.43723924
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36691045
17NIK/NF-kappaB signaling (GO:0038061)3.25749649
18neutrophil activation involved in immune response (GO:0002283)3.25553827
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24176036
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16815253
21regulation of T-helper 2 cell differentiation (GO:0045628)3.16761512
22mannose metabolic process (GO:0006013)3.15676397
23protein localization to endosome (GO:0036010)3.15478176
24modulation by symbiont of host cellular process (GO:0044068)3.12137911
25antigen processing and presentation of endogenous antigen (GO:0019883)3.11332061
26detection of other organism (GO:0098543)3.06298606
27cellular response to type I interferon (GO:0071357)3.02996499
28type I interferon signaling pathway (GO:0060337)3.02996499
29response to type I interferon (GO:0034340)2.99182626
30detection of bacterium (GO:0016045)2.95393822
31germinal center formation (GO:0002467)2.91910638
32response to laminar fluid shear stress (GO:0034616)2.91820512
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91189054
34cellular response to virus (GO:0098586)2.90130135
35positive regulation of Cdc42 GTPase activity (GO:0043089)2.86045096
36regulation of interferon-beta biosynthetic process (GO:0045357)2.84943106
37detection of molecule of bacterial origin (GO:0032490)2.83447737
38regulation of mast cell degranulation (GO:0043304)2.81307759
39barbed-end actin filament capping (GO:0051016)2.81005750
40regulation of type I interferon-mediated signaling pathway (GO:0060338)2.79290436
41leukocyte aggregation (GO:0070486)2.78544268
42regulation of leukocyte degranulation (GO:0043300)2.76269849
43detection of external biotic stimulus (GO:0098581)2.76121342
44immunoglobulin mediated immune response (GO:0016064)2.75238347
45negative regulation of cytokine production involved in immune response (GO:0002719)2.72503612
46myeloid dendritic cell differentiation (GO:0043011)2.68509927
47negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.67423591
48positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.66304041
49stress fiber assembly (GO:0043149)2.66084955
50modulation by virus of host process (GO:0019054)2.65826548
51regulation of early endosome to late endosome transport (GO:2000641)2.64264857
52COPI coating of Golgi vesicle (GO:0048205)2.63842857
53Golgi transport vesicle coating (GO:0048200)2.63842857
54regulation of vitamin D biosynthetic process (GO:0060556)2.62731383
55activation of MAPKKK activity (GO:0000185)2.61622228
56pinocytosis (GO:0006907)2.60594097
57negative regulation of type 2 immune response (GO:0002829)2.60462690
58regulation of myeloid leukocyte mediated immunity (GO:0002886)2.58482579
59granulocyte activation (GO:0036230)2.57154417
60regulation of necroptotic process (GO:0060544)2.55746538
61regulation of type 2 immune response (GO:0002828)2.55719478
62regulation of T-helper 1 cell differentiation (GO:0045625)2.54507842
63response to host (GO:0075136)2.53757313
64response to host defenses (GO:0052200)2.53757313
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53757313
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52654945
67response to host immune response (GO:0052572)2.51386549
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51386549
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.51236923
70regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48315649
71positive regulation of type 2 immune response (GO:0002830)2.47814889
72regulation of gamma-delta T cell activation (GO:0046643)2.47806936
73negative regulation of interleukin-6 production (GO:0032715)2.47645181
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.47047291
75regulation of mast cell activation involved in immune response (GO:0033006)2.45500373
76negative regulation of toll-like receptor signaling pathway (GO:0034122)2.44720339
77detection of biotic stimulus (GO:0009595)2.43418110
78regulation of necrotic cell death (GO:0010939)2.42969566
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.42352576
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.41751102
81interferon-gamma-mediated signaling pathway (GO:0060333)2.38865582
82defense response to protozoan (GO:0042832)2.38831877
83response to protozoan (GO:0001562)2.38359720
84negative regulation of innate immune response (GO:0045824)2.38195904
85glycosphingolipid catabolic process (GO:0046479)2.36687010
86positive regulation of cellular amide metabolic process (GO:0034250)2.35174318
87macrophage activation (GO:0042116)2.34770724
88positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.34144254
89negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.34056246
90embryonic process involved in female pregnancy (GO:0060136)2.33063726
91regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.32597609
923-UTR-mediated mRNA stabilization (GO:0070935)2.31936298
93regulation of defense response to virus by virus (GO:0050690)2.30601719
94myeloid cell activation involved in immune response (GO:0002275)2.30164955
95low-density lipoprotein particle clearance (GO:0034383)2.29686582
96regulation of interferon-alpha production (GO:0032647)2.27548928
97regulation of tumor necrosis factor production (GO:0032680)2.26695855
98negative regulation of myeloid cell apoptotic process (GO:0033033)2.26575245
99neutrophil activation (GO:0042119)2.26030074
100cellular extravasation (GO:0045123)2.25339312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human2.87564499
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.75044235
3LXR_22292898_ChIP-Seq_THP-1_Human2.53899788
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52494367
5ELK3_25401928_ChIP-Seq_HUVEC_Human2.46327937
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45258449
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.44578611
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43862248
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.43793329
10MYC_22102868_ChIP-Seq_BL_Human2.40258088
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.38595245
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36091601
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29280215
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15520271
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09721445
16VDR_24763502_ChIP-Seq_THP-1_Human2.08250440
17TCF7_22412390_ChIP-Seq_EML_Mouse2.07026123
18KDM2B_26808549_Chip-Seq_DND41_Human1.99558083
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96979441
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95114061
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94495223
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94201454
23* RACK7_27058665_Chip-Seq_MCF-7_Human1.91177467
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.90427030
25MAF_26560356_Chip-Seq_TH1_Human1.86358949
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70916481
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69404316
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69299381
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66035164
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61712350
31* UTX_26944678_Chip-Seq_JUKART_Human1.61656902
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.60776202
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60516630
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.60388744
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.57769958
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.57697277
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57448060
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55560411
39MAF_26560356_Chip-Seq_TH2_Human1.54704624
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53300753
41KDM2B_26808549_Chip-Seq_K562_Human1.49924805
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49218176
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47869059
44SPI1_23127762_ChIP-Seq_K562_Human1.44672487
45* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43610281
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.42577297
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40431488
48ZNF263_19887448_ChIP-Seq_K562_Human1.36764987
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.35449568
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35221846
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33907906
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33773541
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33464912
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.33359991
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33210315
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30785883
57P68_20966046_ChIP-Seq_HELA_Human1.29194236
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26250070
59NCOR1_26117541_ChIP-Seq_K562_Human1.26116040
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25323682
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.24289416
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.23767878
63GATA1_19941826_ChIP-Seq_K562_Human1.22573074
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.22414191
65* SPI1_23547873_ChIP-Seq_NB4_Human1.22308011
66CLOCK_20551151_ChIP-Seq_293T_Human1.20758208
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20550830
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19897307
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19894590
70BCOR_27268052_Chip-Seq_Bcells_Human1.19555790
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17551489
72SMC4_20622854_ChIP-Seq_HELA_Human1.17038818
73BCL6_27268052_Chip-Seq_Bcells_Human1.16789894
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15427564
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14226682
76ATF3_27146783_Chip-Seq_COLON_Human1.13690402
77SCL_19346495_ChIP-Seq_HPC-7_Human1.13387416
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13137023
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11843431
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11436723
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10749525
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10708885
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10016911
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09815374
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.09774933
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09653852
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08130764
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07532344
89TP53_22127205_ChIP-Seq_IMR90_Human1.06249661
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05468651
91CREB1_26743006_Chip-Seq_LNCaP_Human1.03941935
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02908593
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02715300
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02124123
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00230362
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99645816
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99550657
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99117493
99DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99055043
100MYB_26560356_Chip-Seq_TH1_Human0.98928144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.33216965
2MP0003436_decreased_susceptibility_to3.67801584
3MP0005058_abnormal_lysosome_morphology2.97501948
4MP0005451_abnormal_body_composition2.89829419
5MP0003300_gastrointestinal_ulcer2.79034846
6MP0003724_increased_susceptibility_to2.71627424
7MP0009840_abnormal_foam_cell2.61736394
8MP0003191_abnormal_cellular_cholesterol2.43051050
9MP0003705_abnormal_hypodermis_morpholog2.41037071
10MP0002419_abnormal_innate_immunity2.29018105
11MP0001835_abnormal_antigen_presentation2.26582820
12MP0005025_abnormal_response_to2.25089238
13MP0008260_abnormal_autophagy2.23465831
14MP0009785_altered_susceptibility_to2.23248998
15MP0005000_abnormal_immune_tolerance2.22812018
16MP0006082_CNS_inflammation2.19469024
17MP0004510_myositis2.17953771
18MP0004947_skin_inflammation2.15861764
19MP0002148_abnormal_hypersensitivity_rea2.13828990
20MP0001790_abnormal_immune_system2.08509271
21MP0005387_immune_system_phenotype2.08509271
22MP0001533_abnormal_skeleton_physiology2.02200742
23MP0009278_abnormal_bone_marrow1.98597468
24MP0000685_abnormal_immune_system1.95806342
25MP0003172_abnormal_lysosome_physiology1.93101262
26MP0002723_abnormal_immune_serum1.81256023
27MP0001800_abnormal_humoral_immune1.78965760
28MP0002452_abnormal_antigen_presenting1.77855779
29MP0000858_altered_metastatic_potential1.75844330
30MP0005464_abnormal_platelet_physiology1.72348356
31MP0002420_abnormal_adaptive_immunity1.68284722
32MP0001819_abnormal_immune_cell1.67155877
33MP0003453_abnormal_keratinocyte_physiol1.66507085
34MP0003075_altered_response_to1.64238668
35MP0010155_abnormal_intestine_physiology1.63240198
36MP0008438_abnormal_cutaneous_collagen1.61712204
37MP0002998_abnormal_bone_remodeling1.59007795
38MP0005671_abnormal_response_to1.57802387
39MP0005076_abnormal_cell_differentiation1.56897529
40MP0009333_abnormal_splenocyte_physiolog1.51228663
41MP0003566_abnormal_cell_adhesion1.48030695
42MP0000604_amyloidosis1.46584302
43MP0003763_abnormal_thymus_physiology1.44781622
44MP0003091_abnormal_cell_migration1.44174522
45MP0001845_abnormal_inflammatory_respons1.43358573
46MP0000343_altered_response_to1.40623232
47MP0004858_abnormal_nervous_system1.40561077
48MP0002405_respiratory_system_inflammati1.39539542
49MP0001545_abnormal_hematopoietic_system1.36299802
50MP0005397_hematopoietic_system_phenotyp1.36299802
51MP0003656_abnormal_erythrocyte_physiolo1.31459132
52MP0009764_decreased_sensitivity_to1.31179167
53MP0003329_amyloid_beta_deposits1.28188539
54MP0008469_abnormal_protein_level1.27676236
55MP0002398_abnormal_bone_marrow1.27160815
56MP0003279_aneurysm1.27005041
57MP0000716_abnormal_immune_system1.25359700
58MP0001348_abnormal_lacrimal_gland1.24991147
59MP0003828_pulmonary_edema1.23931979
60MP0001853_heart_inflammation1.23188899
61MP0008004_abnormal_stomach_pH1.22371948
62MP0005023_abnormal_wound_healing1.21802909
63MP0003448_altered_tumor_morphology1.16150194
64MP0001851_eye_inflammation1.15608829
65MP0002877_abnormal_melanocyte_morpholog1.12014675
66MP0005166_decreased_susceptibility_to1.11927579
67MP0005390_skeleton_phenotype1.10362603
68MP0002139_abnormal_hepatobiliary_system1.08564740
69MP0002429_abnormal_blood_cell1.07360704
70MP0005310_abnormal_salivary_gland1.05849702
71MP0005164_abnormal_response_to1.03624791
72MP0002722_abnormal_immune_system1.02394146
73MP0002132_abnormal_respiratory_system0.98194369
74MP0002933_joint_inflammation0.97884770
75MP0001958_emphysema0.94957616
76MP0001873_stomach_inflammation0.93919037
77MP0000689_abnormal_spleen_morphology0.92571864
78MP0001849_ear_inflammation0.92422839
79MP0003183_abnormal_peptide_metabolism0.92000024
80MP0003866_abnormal_defecation0.87872488
81MP0004185_abnormal_adipocyte_glucose0.87024707
82MP0005666_abnormal_adipose_tissue0.85113426
83MP0003795_abnormal_bone_structure0.82666701
84MP0001542_abnormal_bone_strength0.79259024
85MP0005257_abnormal_intraocular_pressure0.77839620
86MP0004808_abnormal_hematopoietic_stem0.77049009
87MP0009763_increased_sensitivity_to0.76874253
88MP0000703_abnormal_thymus_morphology0.76758006
89MP0000249_abnormal_blood_vessel0.76557202
90MP0001663_abnormal_digestive_system0.75574714
91MP0003690_abnormal_glial_cell0.75315574
92MP0008874_decreased_physiological_sensi0.75238660
93MP0000767_abnormal_smooth_muscle0.75169924
94MP0000465_gastrointestinal_hemorrhage0.74356580
95MP0004883_abnormal_blood_vessel0.74061334
96MP0000490_abnormal_crypts_of0.71910112
97MP0000609_abnormal_liver_physiology0.71348012
98MP0006054_spinal_hemorrhage0.71183542
99MP0005375_adipose_tissue_phenotype0.69966044
100MP0004264_abnormal_extraembryonic_tissu0.69652395

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.05005303
2Abnormality of macrophages (HP:0004311)3.94729158
3Abnormality of glycolipid metabolism (HP:0010969)3.75468177
4Abnormality of liposaccharide metabolism (HP:0010968)3.75468177
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.75468177
6Orchitis (HP:0100796)3.26036414
7Myositis (HP:0100614)3.25363011
8Recurrent abscess formation (HP:0002722)3.23782676
9Recurrent bacterial skin infections (HP:0005406)3.23115148
10Vertebral compression fractures (HP:0002953)3.01147616
11Dysostosis multiplex (HP:0000943)2.99063396
12Systemic lupus erythematosus (HP:0002725)2.81392412
13Recurrent gram-negative bacterial infections (HP:0005420)2.70162096
14Optic neuritis (HP:0100653)2.68834739
15Retrobulbar optic neuritis (HP:0100654)2.68834739
16Increased IgE level (HP:0003212)2.65699709
17Cellulitis (HP:0100658)2.64491032
18Increased cerebral lipofuscin (HP:0011813)2.64235860
19Mediastinal lymphadenopathy (HP:0100721)2.63647416
20Elevated erythrocyte sedimentation rate (HP:0003565)2.62774331
21Loss of speech (HP:0002371)2.54688036
22Gastrointestinal infarctions (HP:0005244)2.52803524
23Chronic obstructive pulmonary disease (HP:0006510)2.52696615
24Obstructive lung disease (HP:0006536)2.52696615
25Amyloidosis (HP:0011034)2.51808066
26Peritonitis (HP:0002586)2.50847727
27Protrusio acetabuli (HP:0003179)2.50549958
28Purpura (HP:0000979)2.44176027
29Interstitial pulmonary disease (HP:0006530)2.41185646
30Abnormality of polysaccharide metabolism (HP:0011012)2.39827046
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39827046
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39827046
33Gingivitis (HP:0000230)2.37546084
34Mucopolysacchariduria (HP:0008155)2.34545322
35Urinary glycosaminoglycan excretion (HP:0003541)2.34545322
36Achilles tendon contracture (HP:0001771)2.29411413
37Stomatitis (HP:0010280)2.26140282
38Premature rupture of membranes (HP:0001788)2.23299966
39Increased serum ferritin (HP:0003281)2.22850307
40Thin bony cortex (HP:0002753)2.21866381
41Neurofibrillary tangles (HP:0002185)2.20664302
42Hemorrhage of the eye (HP:0011885)2.15193660
43Abnormality of the Achilles tendon (HP:0005109)2.14876763
44Colitis (HP:0002583)2.14300520
45Vasculitis (HP:0002633)2.11909200
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.11625759
47Vacuolated lymphocytes (HP:0001922)2.10134010
48Abnormality of the nasal mucosa (HP:0000433)2.09072678
49Axonal loss (HP:0003447)2.07743781
50Segmental peripheral demyelination/remyelination (HP:0003481)2.07390345
51Cervical subluxation (HP:0003308)2.06054303
52Recurrent skin infections (HP:0001581)2.05799555
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05768779
54Meningitis (HP:0001287)2.05542313
55Urticaria (HP:0001025)2.02734410
56Myocardial infarction (HP:0001658)2.01186546
57Cerebral inclusion bodies (HP:0100314)1.99615193
58Emphysema (HP:0002097)1.99195038
59Recurrent viral infections (HP:0004429)1.98997443
60Cerebral aneurysm (HP:0004944)1.98908419
61Nuclear cataract (HP:0100018)1.98761393
62Polygenic inheritance (HP:0010982)1.97560362
63Gastrointestinal inflammation (HP:0004386)1.96772225
64Nasal polyposis (HP:0100582)1.96466763
65Recurrent fungal infections (HP:0002841)1.96250829
66Hypertensive crisis (HP:0100735)1.94653534
67Spondylolisthesis (HP:0003302)1.93981705
68Gastrointestinal stroma tumor (HP:0100723)1.92214694
69Slow saccadic eye movements (HP:0000514)1.91591705
70Spontaneous hematomas (HP:0007420)1.91212273
71Hyperparathyroidism (HP:0000843)1.90380586
72Thoracic kyphosis (HP:0002942)1.90322373
73Dilatation of the ascending aorta (HP:0005111)1.89924874
74Deep venous thrombosis (HP:0002625)1.88718665
75Episodic fever (HP:0001954)1.88577939
76Keratoconjunctivitis sicca (HP:0001097)1.88399208
77Abnormality of complement system (HP:0005339)1.86559741
78Neuronal loss in central nervous system (HP:0002529)1.85667390
79Pulmonary infiltrates (HP:0002113)1.85313431
80Asymmetric septal hypertrophy (HP:0001670)1.84554040
81Broad face (HP:0000283)1.83587040
82Inflammation of the large intestine (HP:0002037)1.83392527
83Petechiae (HP:0000967)1.82621756
84Bone pain (HP:0002653)1.82366521
85Polycythemia (HP:0001901)1.81157853
86Blue sclerae (HP:0000592)1.81005223
87Distal lower limb muscle weakness (HP:0009053)1.78524213
88Abnormality of the peritoneum (HP:0002585)1.78376525
89Abnormality of the thoracic spine (HP:0100711)1.78304751
90Increased connective tissue (HP:0009025)1.77209967
91Arterial thrombosis (HP:0004420)1.76155407
92Hypertriglyceridemia (HP:0002155)1.75951114
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75084987
94Malnutrition (HP:0004395)1.75065443
95Personality changes (HP:0000751)1.75024601
96Hypergammaglobulinemia (HP:0010702)1.74689517
97Upper motor neuron abnormality (HP:0002127)1.73307297
98Autoimmune thrombocytopenia (HP:0001973)1.70482258
99Supranuclear gaze palsy (HP:0000605)1.69903430
100Progressive neurologic deterioration (HP:0002344)1.68844249

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.96423379
2TRIB33.31013530
3PRPF4B3.12981928
4IRAK32.83262931
5RIPK42.52221268
6MAP2K32.22471091
7NME22.14383132
8RIPK12.04878356
9MAP3K112.03873347
10SIK12.02672220
11SMG12.02114744
12MAP4K12.01393954
13TAOK21.95715187
14TBK11.92519581
15MAP3K31.84362345
16TYK21.79658944
17ICK1.77881937
18IRAK41.72873341
19CDK121.62857564
20MAP3K141.61174665
21TESK21.59302037
22TAOK11.57655825
23TESK11.54834080
24EPHB11.45995277
25MAP3K11.43627291
26BLK1.42531656
27CSK1.33684714
28ZAP701.31309962
29DDR21.24456747
30FGFR41.23284248
31PIM21.22326216
32ARAF1.20717217
33JAK31.19546297
34MARK21.18379826
35MAP3K131.16760568
36EPHA21.13135006
37IKBKE1.12862247
38KSR21.09565631
39CDC42BPA1.09128719
40SIK31.05422890
41GRK61.04808419
42PRKD21.02145804
43IKBKB1.01855619
44FES1.01189192
45MOS0.98750173
46PKN20.95354471
47MATK0.93881935
48TTN0.91141303
49PDPK10.90553409
50TGFBR20.88727578
51RPS6KA20.87681817
52BTK0.87230196
53EEF2K0.85313848
54JAK10.82264336
55LRRK20.81203626
56RPS6KC10.79698485
57RPS6KL10.79698485
58HCK0.79281790
59TNK20.78583309
60FGR0.78382951
61PTK60.73172852
62HIPK20.72745383
63DYRK1B0.71359405
64PAK40.71252574
65IRAK20.70860192
66PDGFRA0.70437444
67PDK10.68514229
68STK380.68341181
69JAK20.64726229
70SIK20.64430411
71MAP2K20.62451815
72BMX0.62143027
73CSF1R0.61016745
74CHUK0.60646644
75RPS6KA60.60182477
76BRAF0.60165429
77ABL20.60020331
78SYK0.59054203
79MAP3K60.57803158
80MTOR0.57002957
81STK100.54114942
82GRK70.53497079
83MAP3K80.52670644
84LATS20.52222614
85BMPR20.51266453
86LCK0.49652216
87CAMKK10.47894505
88MARK30.47484059
89MAP3K100.47323447
90MAPK110.45865500
91LYN0.45403739
92IRAK10.43572584
93TYRO30.43258040
94RET0.42522569
95CDK40.41029251
96MAPKAPK20.40555290
97PRKG20.39768950
98SGK30.39176059
99MAP3K20.38695412
100LMTK20.38144236

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.79993374
2Osteoclast differentiation_Homo sapiens_hsa043802.47654072
3Leishmaniasis_Homo sapiens_hsa051402.23009588
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22029778
5B cell receptor signaling pathway_Homo sapiens_hsa046622.02216190
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98886946
7Acute myeloid leukemia_Homo sapiens_hsa052211.94432617
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92360175
9Malaria_Homo sapiens_hsa051441.82183686
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.77268819
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.74697340
12Staphylococcus aureus infection_Homo sapiens_hsa051501.74658155
13TNF signaling pathway_Homo sapiens_hsa046681.74242306
14Tuberculosis_Homo sapiens_hsa051521.62391980
15Lysosome_Homo sapiens_hsa041421.60788199
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59284603
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54342269
18Influenza A_Homo sapiens_hsa051641.53956209
19Chronic myeloid leukemia_Homo sapiens_hsa052201.51189237
20Toxoplasmosis_Homo sapiens_hsa051451.48167400
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47507038
22Prion diseases_Homo sapiens_hsa050201.41545417
23VEGF signaling pathway_Homo sapiens_hsa043701.40764849
24Allograft rejection_Homo sapiens_hsa053301.40524741
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39596120
26Hepatitis C_Homo sapiens_hsa051601.38391554
27Bladder cancer_Homo sapiens_hsa052191.36839204
28Pertussis_Homo sapiens_hsa051331.35655448
29Salmonella infection_Homo sapiens_hsa051321.33377175
30Measles_Homo sapiens_hsa051621.31063112
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29488285
32Graft-versus-host disease_Homo sapiens_hsa053321.28898883
33Hepatitis B_Homo sapiens_hsa051611.28720403
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28526831
35Shigellosis_Homo sapiens_hsa051311.25479071
36Non-small cell lung cancer_Homo sapiens_hsa052231.24378969
37Pancreatic cancer_Homo sapiens_hsa052121.22881891
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22266932
39Apoptosis_Homo sapiens_hsa042101.20945141
40Notch signaling pathway_Homo sapiens_hsa043301.19679659
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19343958
42Autoimmune thyroid disease_Homo sapiens_hsa053201.17048790
43T cell receptor signaling pathway_Homo sapiens_hsa046601.15996163
44Legionellosis_Homo sapiens_hsa051341.15661572
45Chemokine signaling pathway_Homo sapiens_hsa040621.13813029
46Herpes simplex infection_Homo sapiens_hsa051681.11234874
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.10468394
48Rheumatoid arthritis_Homo sapiens_hsa053231.07868783
49Amoebiasis_Homo sapiens_hsa051461.06057539
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.03379839
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.03353155
52Adipocytokine signaling pathway_Homo sapiens_hsa049201.01969437
53Viral myocarditis_Homo sapiens_hsa054161.01799746
54Renal cell carcinoma_Homo sapiens_hsa052110.98884469
55Hematopoietic cell lineage_Homo sapiens_hsa046400.97536904
56Phagosome_Homo sapiens_hsa041450.97114241
57African trypanosomiasis_Homo sapiens_hsa051430.96456113
58Prolactin signaling pathway_Homo sapiens_hsa049170.94356682
59Endocytosis_Homo sapiens_hsa041440.92363278
60Antigen processing and presentation_Homo sapiens_hsa046120.89628427
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.86465258
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86449886
63Primary immunodeficiency_Homo sapiens_hsa053400.83970655
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81281578
65Endometrial cancer_Homo sapiens_hsa052130.80825699
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.80806701
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80459491
68Fructose and mannose metabolism_Homo sapiens_hsa000510.79807143
69Viral carcinogenesis_Homo sapiens_hsa052030.71999723
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70393630
71Asthma_Homo sapiens_hsa053100.70085384
72HTLV-I infection_Homo sapiens_hsa051660.69234919
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.68916078
74Vibrio cholerae infection_Homo sapiens_hsa051100.67807898
75mTOR signaling pathway_Homo sapiens_hsa041500.67716049
76Epstein-Barr virus infection_Homo sapiens_hsa051690.67598182
77Galactose metabolism_Homo sapiens_hsa000520.66672344
78ErbB signaling pathway_Homo sapiens_hsa040120.66387436
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66096175
80GnRH signaling pathway_Homo sapiens_hsa049120.65698276
81Type I diabetes mellitus_Homo sapiens_hsa049400.65164970
82HIF-1 signaling pathway_Homo sapiens_hsa040660.64980260
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.63215322
84Proteoglycans in cancer_Homo sapiens_hsa052050.61977346
85Insulin resistance_Homo sapiens_hsa049310.61100774
86Pentose phosphate pathway_Homo sapiens_hsa000300.57591072
87Platelet activation_Homo sapiens_hsa046110.55991441
88FoxO signaling pathway_Homo sapiens_hsa040680.55975624
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55896020
90Insulin signaling pathway_Homo sapiens_hsa049100.55869219
91Glioma_Homo sapiens_hsa052140.55681892
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55120280
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54798639
94Prostate cancer_Homo sapiens_hsa052150.54426431
95Complement and coagulation cascades_Homo sapiens_hsa046100.54032812
96Small cell lung cancer_Homo sapiens_hsa052220.51135239
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50935958
98Focal adhesion_Homo sapiens_hsa045100.48077907
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48043375
100Sphingolipid metabolism_Homo sapiens_hsa006000.47331373

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