STX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic sister chromatid separation (GO:1901970)4.79071518
2positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.79071518
3positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.79071518
4regulation of sister chromatid cohesion (GO:0007063)3.97305558
5positive regulation of chromosome segregation (GO:0051984)3.97026910
6negative regulation of Ras GTPase activity (GO:0034261)3.96903643
7peptidyl-lysine dimethylation (GO:0018027)3.93208189
8central nervous system myelination (GO:0022010)3.76501642
9axon ensheathment in central nervous system (GO:0032291)3.76501642
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57739974
11negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.43601876
12regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.34156054
13hemidesmosome assembly (GO:0031581)3.28507289
14protein prenylation (GO:0018342)3.27751998
15prenylation (GO:0097354)3.27751998
16regulation of beta-amyloid formation (GO:1902003)3.25828949
17nuclear pore complex assembly (GO:0051292)3.19104533
18epithelial cell differentiation involved in prostate gland development (GO:0060742)3.12629695
19regulation of mononuclear cell migration (GO:0071675)3.01597272
20histone H3-K36 demethylation (GO:0070544)3.00876276
21regulation of mammary gland epithelial cell proliferation (GO:0033599)2.96045001
22regulation of DNA methylation (GO:0044030)2.94102635
23dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.92945294
24synaptic vesicle maturation (GO:0016188)2.92548557
25negative regulation of GTP catabolic process (GO:0033125)2.91448603
26negative regulation of GTPase activity (GO:0034260)2.91448603
27cytoskeletal anchoring at plasma membrane (GO:0007016)2.88541303
28nerve growth factor signaling pathway (GO:0038180)2.86565653
29localization within membrane (GO:0051668)2.85411502
30protein targeting to lysosome (GO:0006622)2.82243635
31establishment of protein localization to vacuole (GO:0072666)2.82243635
32protein targeting to vacuole (GO:0006623)2.82243635
33positive regulation of gamma-delta T cell activation (GO:0046645)2.81737775
34negative regulation of keratinocyte proliferation (GO:0010839)2.78963840
35surfactant homeostasis (GO:0043129)2.78868670
36regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.73801276
37regulation of NFAT protein import into nucleus (GO:0051532)2.68818724
38amino acid import (GO:0043090)2.68707891
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67709682
40substrate-independent telencephalic tangential migration (GO:0021826)2.66703177
41substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.66703177
42regulation of early endosome to late endosome transport (GO:2000641)2.65523156
43regulation of amyloid precursor protein catabolic process (GO:1902991)2.64086533
44regulation of cellular amide metabolic process (GO:0034248)2.63669242
45cell-substrate junction assembly (GO:0007044)2.61741648
46nuclear pore organization (GO:0006999)2.60948597
47regulation of nucleobase-containing compound transport (GO:0032239)2.59172300
48positive regulation of keratinocyte differentiation (GO:0045618)2.56113140
49positive T cell selection (GO:0043368)2.55411221
50negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.53532029
51negative regulation of histone methylation (GO:0031061)2.52795098
52pre-miRNA processing (GO:0031054)2.52685073
53cerebral cortex radially oriented cell migration (GO:0021799)2.52226950
54detection of molecule of bacterial origin (GO:0032490)2.52191193
55adenosine receptor signaling pathway (GO:0001973)2.51628139
56negative T cell selection (GO:0043383)2.50977630
57positive regulation of cellular amide metabolic process (GO:0034250)2.49909273
58layer formation in cerebral cortex (GO:0021819)2.49202710
593-UTR-mediated mRNA stabilization (GO:0070935)2.49161811
60leukocyte aggregation (GO:0070486)2.49161355
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48462364
62regulation of RNA export from nucleus (GO:0046831)2.45247833
63ensheathment of neurons (GO:0007272)2.44843508
64axon ensheathment (GO:0008366)2.44843508
65myelination (GO:0042552)2.44368411
66chemical homeostasis within a tissue (GO:0048875)2.43071773
67dendrite morphogenesis (GO:0048813)2.41122816
68activated T cell proliferation (GO:0050798)2.39893353
69cytoplasmic mRNA processing body assembly (GO:0033962)2.37204079
70negative thymic T cell selection (GO:0045060)2.37153752
71activation of Rac GTPase activity (GO:0032863)2.35280652
72skin morphogenesis (GO:0043589)2.34733908
73histone H3-K9 demethylation (GO:0033169)2.34611237
74photoreceptor cell differentiation (GO:0046530)2.34558028
75eye photoreceptor cell differentiation (GO:0001754)2.34558028
76labyrinthine layer development (GO:0060711)2.33875085
77response to muramyl dipeptide (GO:0032495)2.33547894
78locomotory exploration behavior (GO:0035641)2.33460438
79regulation of histone H3-K9 methylation (GO:0051570)2.33379308
80establishment of mitotic spindle orientation (GO:0000132)2.33058737
81pore complex assembly (GO:0046931)2.32752391
82establishment of spindle orientation (GO:0051294)2.32258672
83positive regulation of Cdc42 GTPase activity (GO:0043089)2.31688034
84positive regulation of receptor recycling (GO:0001921)2.31645790
85adherens junction assembly (GO:0034333)2.30767425
86embryonic process involved in female pregnancy (GO:0060136)2.30544825
87focal adhesion assembly (GO:0048041)2.30286527
88cell-substrate adherens junction assembly (GO:0007045)2.30286527
89negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30272778
90positive regulation of interleukin-17 production (GO:0032740)2.30188812
91peptidyl-threonine modification (GO:0018210)2.29873704
92NIK/NF-kappaB signaling (GO:0038061)2.29605654
93negative regulation of adherens junction organization (GO:1903392)2.29302265
94negative regulation of focal adhesion assembly (GO:0051895)2.29302265
95negative regulation of cell junction assembly (GO:1901889)2.29302265
96RNA stabilization (GO:0043489)2.29003788
97mRNA stabilization (GO:0048255)2.29003788
98histone lysine demethylation (GO:0070076)2.28105815
99negative regulation of macroautophagy (GO:0016242)2.27938850
100regulation of synaptic vesicle exocytosis (GO:2000300)2.27785845
101ionotropic glutamate receptor signaling pathway (GO:0035235)2.27572185
102regulation of water loss via skin (GO:0033561)2.25740300
103stress fiber assembly (GO:0043149)2.24717381
104negative regulation of dendrite morphogenesis (GO:0050774)2.23959797
105branching involved in mammary gland duct morphogenesis (GO:0060444)2.23638985
106oocyte development (GO:0048599)2.23584115
107cortical actin cytoskeleton organization (GO:0030866)2.23504234
108neuron projection extension (GO:1990138)2.22837230
109regulation of interleukin-12 biosynthetic process (GO:0045075)2.22552699
110regulation of transforming growth factor beta2 production (GO:0032909)2.22306958
111response to nerve growth factor (GO:1990089)2.22211011
112cellular response to nerve growth factor stimulus (GO:1990090)2.22211011
113peptidyl-tyrosine autophosphorylation (GO:0038083)2.20232086
114regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.19429849
115negative regulation of neurotransmitter secretion (GO:0046929)2.19000236
116positive regulation of T cell cytokine production (GO:0002726)2.18879635
117positive regulation of oligodendrocyte differentiation (GO:0048714)2.18443150
118negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.17953987
119paraxial mesoderm development (GO:0048339)2.17654996
120negative regulation of T cell receptor signaling pathway (GO:0050860)2.16900863
121acrosome assembly (GO:0001675)2.16690196
122presynaptic membrane organization (GO:0097090)2.16033862
123modulation by symbiont of host cellular process (GO:0044068)2.14718025
124T cell selection (GO:0045058)2.14666000
125response to lipoprotein particle (GO:0055094)2.13920938
126Notch signaling involved in heart development (GO:0061314)2.13887670
127regulation of interleukin-2 biosynthetic process (GO:0045076)2.13789323
128histone demethylation (GO:0016577)2.13135182
129negative regulation of Ras protein signal transduction (GO:0046580)2.12695299
130positive thymic T cell selection (GO:0045059)2.12660288
131peptidyl-threonine phosphorylation (GO:0018107)2.12411004
132presynaptic membrane assembly (GO:0097105)2.11739064
133negative regulation of cell killing (GO:0031342)2.11693339
134negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.11693339
135dendritic spine morphogenesis (GO:0060997)2.11198547
136mast cell activation (GO:0045576)2.11014096
137synaptic vesicle exocytosis (GO:0016079)2.10420711
138organ growth (GO:0035265)2.09748428
139dendritic spine organization (GO:0097061)2.09366580
140protein localization to synapse (GO:0035418)2.09216538
141regulation of short-term neuronal synaptic plasticity (GO:0048172)2.08881307
142cell adhesion mediated by integrin (GO:0033627)2.08420566
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.08118466
144regulation of chronic inflammatory response (GO:0002676)2.05123826
145regulation of voltage-gated calcium channel activity (GO:1901385)2.05020588
146cyclic nucleotide catabolic process (GO:0009214)2.05006498
147neuron cell-cell adhesion (GO:0007158)2.04067262
148transmission of nerve impulse (GO:0019226)2.03771851
149regulation of Rap GTPase activity (GO:0032317)2.02997657
150positive regulation of interleukin-2 production (GO:0032743)2.02065455
151Rap protein signal transduction (GO:0032486)2.01763669
152negative regulation of amino acid transport (GO:0051956)2.01263132
153oligodendrocyte differentiation (GO:0048709)2.00611798
154regulation of gamma-delta T cell activation (GO:0046643)1.99924860
155neuron recognition (GO:0008038)1.99628726
156negative regulation of axonogenesis (GO:0050771)1.99544790
157regulation of interleukin-17 production (GO:0032660)1.98483073
158modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.97407421
159positive regulation by organism of defense response of other organism involved in symbiotic interact1.97407421
160modulation by symbiont of host immune response (GO:0052553)1.97407421
161positive regulation by symbiont of host defense response (GO:0052509)1.97407421
162modulation by symbiont of host defense response (GO:0052031)1.97407421
163modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.97407421
164regulation of ARF GTPase activity (GO:0032312)1.97374784
165positive regulation of calcium ion-dependent exocytosis (GO:0045956)1.96443004
166L-amino acid import (GO:0043092)1.96009532
167neuronal action potential propagation (GO:0019227)1.95827726
168myelin maintenance (GO:0043217)1.94854355
169regulation of glutamate receptor signaling pathway (GO:1900449)1.93921836
170regulation of synapse structural plasticity (GO:0051823)1.93555913
171axonal fasciculation (GO:0007413)1.93384161
172regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)1.92688417
173regulation of ARF protein signal transduction (GO:0032012)1.91519856
174regulation of neuronal synaptic plasticity (GO:0048168)1.91456155
175protein localization to endosome (GO:0036010)1.90686058
176regulation of synaptic vesicle transport (GO:1902803)1.90625298
177positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)1.89208665
178antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G1.88521526
179positive regulation of heat generation (GO:0031652)1.88344371
180regulation of vesicle fusion (GO:0031338)1.88220737
181long-chain fatty acid biosynthetic process (GO:0042759)1.88187233
182regulation of neuron projection regeneration (GO:0070570)1.87429024
183regulation of axon regeneration (GO:0048679)1.87429024
184negative regulation of neurotransmitter transport (GO:0051589)1.86556241
185regulation of isotype switching to IgG isotypes (GO:0048302)1.86309342
186positive regulation of Rap GTPase activity (GO:0032854)1.86194295
187thymic T cell selection (GO:0045061)1.86161334
188semaphorin-plexin signaling pathway (GO:0071526)1.86161271
189negative regulation of execution phase of apoptosis (GO:1900118)1.85527092
190asymmetric protein localization (GO:0008105)1.85449215
191modulation by virus of host process (GO:0019054)1.84862804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.84719132
2GATA1_22025678_ChIP-Seq_K562_Human3.71056586
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.90436283
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70545664
5EZH2_22144423_ChIP-Seq_EOC_Human2.58554560
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42266895
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.41237563
8GBX2_23144817_ChIP-Seq_PC3_Human2.33296268
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31179227
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.26314874
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.25274039
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.25274039
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.25274039
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22198732
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18970522
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17688483
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13079036
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13079036
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12083545
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09790961
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02002590
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.95546878
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95183605
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95119618
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94941600
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94053025
27DROSHA_22980978_ChIP-Seq_HELA_Human1.93887433
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.91867368
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.91369718
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90516425
31AR_21572438_ChIP-Seq_LNCaP_Human1.86861475
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86526539
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.86300880
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.85384673
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.83220483
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79734231
37* CLOCK_20551151_ChIP-Seq_293T_Human1.77812080
38RUNX_20019798_ChIP-Seq_JUKART_Human1.72567848
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.70282717
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.69339027
41* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67806277
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64888762
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.59880814
44* WT1_19549856_ChIP-ChIP_CCG9911_Human1.57198556
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57172763
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.56511757
47TCF7_22412390_ChIP-Seq_EML_Mouse1.53963913
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51067601
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50968028
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50304954
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45560331
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44534790
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43858874
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.42484414
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.39754660
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39157355
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38755781
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35484608
59* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34841892
60* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34841892
61IGF1R_20145208_ChIP-Seq_DFB_Human1.34214982
62* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32260245
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.31751302
64* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30386737
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28340898
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27521838
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27457271
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25667345
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25527607
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25394199
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23015078
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22274556
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22168271
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21244114
75UBF1/2_26484160_Chip-Seq_HMECs_Human1.21087817
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20561346
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20427618
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20145348
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19767637
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.19593540
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18439063
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17985102
83KDM2B_26808549_Chip-Seq_K562_Human1.17843115
84REST_21632747_ChIP-Seq_MESCs_Mouse1.17704776
85* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17553783
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17059160
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16657207
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16630204
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.16520053
90KDM2B_26808549_Chip-Seq_DND41_Human1.16197550
91* ELK3_25401928_ChIP-Seq_HUVEC_Human1.15302167
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15142849
93SPI1_23127762_ChIP-Seq_K562_Human1.15024883
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14485150
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14373074
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.14080848
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.14051066
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12084218
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12084218
100IRF8_27001747_Chip-Seq_BMDM_Mouse1.11387572
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.11385598
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.11123935
103BP1_19119308_ChIP-ChIP_Hs578T_Human1.10691954
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.10599455
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10463530
106* VDR_24787735_ChIP-Seq_THP-1_Human1.08503381
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08101771
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07894028
109* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07706400
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06943003
111AHR_22903824_ChIP-Seq_MCF-7_Human1.06551449
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06346813
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05237523
114TP53_16413492_ChIP-PET_HCT116_Human1.05059459
115* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04242705
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.03709523
117* PU_27001747_Chip-Seq_BMDM_Mouse1.03657745
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02830272
119AR_21909140_ChIP-Seq_LNCAP_Human1.02496414
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01468886
121GF1_26923725_Chip-Seq_HPCs_Mouse1.01383749
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01358643
123* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00588240
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99677038
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99239327
126TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98845394
127EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98129151
128TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98092387
129* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97967154
130ARNT_22903824_ChIP-Seq_MCF-7_Human0.97743172
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97196267
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.95697772
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95322596
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.95301721
135MYC_22102868_ChIP-Seq_BL_Human0.95275645
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95095548
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94733140
138STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94384384
139ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93910089
140* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93810607
141PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93737497
142NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93408493
143P300_19829295_ChIP-Seq_ESCs_Human0.92850170
144SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92148045
145TP53_18474530_ChIP-ChIP_U2OS_Human0.92075241
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91699486
147SMAD4_21799915_ChIP-Seq_A2780_Human0.91334408
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91284832
149SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91022054
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90308392
151TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90248637
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89866530
153NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89474729
154TP63_17297297_ChIP-ChIP_HaCaT_Human0.89036679
155REST_18959480_ChIP-ChIP_MESCs_Mouse0.88715578
156RXR_22108803_ChIP-Seq_LS180_Human0.87471685
157ER_23166858_ChIP-Seq_MCF-7_Human0.85830432
158STAT3_23295773_ChIP-Seq_U87_Human0.83842443
159* VDR_24763502_ChIP-Seq_THP-1_Human0.83306265
160STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83047155
161* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82946643
162TRIM28_21343339_ChIP-Seq_HEK293_Human0.81962826
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.81619548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.40757217
2MP0004859_abnormal_synaptic_plasticity3.90331620
3MP0010234_abnormal_vibrissa_follicle3.32320102
4MP0003880_abnormal_central_pattern3.16940166
5MP0000566_synostosis3.13244537
6MP0008057_abnormal_DNA_replication2.85341443
7MP0003453_abnormal_keratinocyte_physiol2.78113934
8MP0002877_abnormal_melanocyte_morpholog2.70699683
9MP0003941_abnormal_skin_development2.55565650
10MP0000920_abnormal_myelination2.55266910
11MP0005076_abnormal_cell_differentiation2.53206437
12MP0003303_peritoneal_inflammation2.35604279
13MP0003566_abnormal_cell_adhesion2.30307242
14MP0002796_impaired_skin_barrier2.24493678
15MP0004510_myositis2.20202019
16MP0010352_gastrointestinal_tract_polyps2.09512378
17MP0003635_abnormal_synaptic_transmissio2.09459491
18MP0000579_abnormal_nail_morphology2.06667842
19MP0004270_analgesia2.03534580
20MP0001849_ear_inflammation1.88065613
21MP0005671_abnormal_response_to1.86193773
22MP0005409_darkened_coat_color1.76996212
23MP0000569_abnormal_digit_pigmentation1.75602452
24MP0000685_abnormal_immune_system1.75179147
25MP0002063_abnormal_learning/memory/cond1.70000522
26MP0003300_gastrointestinal_ulcer1.69739554
27MP0005501_abnormal_skin_physiology1.69054572
28MP0001915_intracranial_hemorrhage1.67881768
29MP0004185_abnormal_adipocyte_glucose1.67566680
30MP0009745_abnormal_behavioral_response1.66600969
31MP0005000_abnormal_immune_tolerance1.63437464
32MP0008260_abnormal_autophagy1.62814625
33MP0005423_abnormal_somatic_nervous1.62162080
34MP0003763_abnormal_thymus_physiology1.62032850
35MP0000778_abnormal_nervous_system1.61996272
36MP0001486_abnormal_startle_reflex1.61565170
37MP0010368_abnormal_lymphatic_system1.60790189
38MP0002064_seizures1.58765396
39MP0001835_abnormal_antigen_presentation1.56952076
40MP0004233_abnormal_muscle_weight1.56948423
41MP0000377_abnormal_hair_follicle1.53200956
42MP0001790_abnormal_immune_system1.52902966
43MP0005387_immune_system_phenotype1.52902966
44MP0002148_abnormal_hypersensitivity_rea1.50853728
45MP0002254_reproductive_system_inflammat1.49452643
46MP0002933_joint_inflammation1.47879182
47MP0002272_abnormal_nervous_system1.44847934
48MP0003890_abnormal_embryonic-extraembry1.43037230
49MP0005248_abnormal_Harderian_gland1.41916428
50MP0000467_abnormal_esophagus_morphology1.40404544
51MP0001851_eye_inflammation1.39157613
52MP0004742_abnormal_vestibular_system1.38096075
53MP0000015_abnormal_ear_pigmentation1.38010406
54MP0008569_lethality_at_weaning1.37268371
55MP0000858_altered_metastatic_potential1.35669935
56MP0004885_abnormal_endolymph1.34481059
57MP0005171_absent_coat_pigmentation1.33546376
58MP0009785_altered_susceptibility_to1.33452684
59MP0000428_abnormal_craniofacial_morphol1.33114494
60MP0009053_abnormal_anal_canal1.30120331
61MP0001348_abnormal_lacrimal_gland1.27988548
62MP0003634_abnormal_glial_cell1.26588850
63MP0002419_abnormal_innate_immunity1.24276152
64MP0002089_abnormal_postnatal_growth/wei1.22998634
65MP0005310_abnormal_salivary_gland1.21942930
66MP0002723_abnormal_immune_serum1.21734411
67MP0002572_abnormal_emotion/affect_behav1.20396509
68MP0002420_abnormal_adaptive_immunity1.20329545
69MP0001819_abnormal_immune_cell1.20223886
70MP0003115_abnormal_respiratory_system1.20032934
71MP0004381_abnormal_hair_follicle1.18638669
72MP0002452_abnormal_antigen_presenting1.18020734
73MP0004947_skin_inflammation1.17888007
74MP0002998_abnormal_bone_remodeling1.17045325
75MP0001216_abnormal_epidermal_layer1.16297930
76MP0006082_CNS_inflammation1.15654064
77MP0003950_abnormal_plasma_membrane1.13948185
78MP0009672_abnormal_birth_weight1.10887341
79MP0003448_altered_tumor_morphology1.09434425
80MP0009840_abnormal_foam_cell1.09373785
81MP0005621_abnormal_cell_physiology1.09197270
82MP0005025_abnormal_response_to1.08876391
83MP0003191_abnormal_cellular_cholesterol1.08811505
84MP0004264_abnormal_extraembryonic_tissu1.06747288
85MP0001968_abnormal_touch/_nociception1.04575717
86MP0005257_abnormal_intraocular_pressure1.04267588
87MP0000427_abnormal_hair_cycle1.04142577
88MP0003436_decreased_susceptibility_to1.03548367
89MP0003690_abnormal_glial_cell1.02759202
90MP0003724_increased_susceptibility_to1.00341215
91MP0000350_abnormal_cell_proliferation1.00307224
92MP0001501_abnormal_sleep_pattern0.99801932
93MP0004811_abnormal_neuron_physiology0.99692665
94MP0000955_abnormal_spinal_cord0.99316627
95MP0002882_abnormal_neuron_morphology0.98580820
96MP0002098_abnormal_vibrissa_morphology0.97174391
97MP0005023_abnormal_wound_healing0.96606447
98MP0010678_abnormal_skin_adnexa0.96314150
99MP0000762_abnormal_tongue_morphology0.95465349
100MP0005174_abnormal_tail_pigmentation0.94412000
101MP0002060_abnormal_skin_morphology0.94133213
102MP0003075_altered_response_to0.94104814
103MP0001188_hyperpigmentation0.93383915
104MP0002734_abnormal_mechanical_nocicepti0.92801189
105MP0003329_amyloid_beta_deposits0.91533950
106MP0001346_abnormal_lacrimal_gland0.91503555
107MP0000537_abnormal_urethra_morphology0.91413014
108MP0001485_abnormal_pinna_reflex0.91305072
109MP0003633_abnormal_nervous_system0.90808899
110MP0010771_integument_phenotype0.90381076
111MP0001730_embryonic_growth_arrest0.89586037
112MP0003828_pulmonary_edema0.89042714
113MP0001800_abnormal_humoral_immune0.88652033
114MP0002006_tumorigenesis0.88568864
115MP0005275_abnormal_skin_tensile0.88568442
116MP0002405_respiratory_system_inflammati0.88175566
117MP0005197_abnormal_uvea_morphology0.87911595
118MP0009278_abnormal_bone_marrow0.87626390
119MP0009046_muscle_twitch0.85677064
120MP0005645_abnormal_hypothalamus_physiol0.85131241
121MP0005167_abnormal_blood-brain_barrier0.84494378
122MP0005394_taste/olfaction_phenotype0.84483860
123MP0005499_abnormal_olfactory_system0.84483860
124MP0001502_abnormal_circadian_rhythm0.84428182
125MP0010307_abnormal_tumor_latency0.84303771
126MP0001299_abnormal_eye_distance/0.84224410
127MP0002822_catalepsy0.83902157
128MP0005058_abnormal_lysosome_morphology0.83559675
129MP0005380_embryogenesis_phenotype0.82621901
130MP0001672_abnormal_embryogenesis/_devel0.82621901
131MP0003172_abnormal_lysosome_physiology0.82205400
132MP0000627_abnormal_mammary_gland0.82024900
133MP0003091_abnormal_cell_migration0.81703151
134MP0000604_amyloidosis0.81145603
135MP0002086_abnormal_extraembryonic_tissu0.80959200
136MP0002067_abnormal_sensory_capabilities0.80766316
137MP0004197_abnormal_fetal_growth/weight/0.80750816
138MP0005384_cellular_phenotype0.80712155
139MP0005647_abnormal_sex_gland0.80673782
140MP0001177_atelectasis0.80645456
141MP0001533_abnormal_skeleton_physiology0.80575762
142MP0003984_embryonic_growth_retardation0.80254729
143MP0003123_paternal_imprinting0.80249203
144MP0005451_abnormal_body_composition0.80208599
145MP0000716_abnormal_immune_system0.79609154
146MP0010155_abnormal_intestine_physiology0.79207837
147MP0001970_abnormal_pain_threshold0.78386253
148MP0002398_abnormal_bone_marrow0.78090355
149MP0000432_abnormal_head_morphology0.77078387
150MP0002088_abnormal_embryonic_growth/wei0.76939879
151MP0000383_abnormal_hair_follicle0.76856821
152MP0001905_abnormal_dopamine_level0.76074717
153MP0004858_abnormal_nervous_system0.75849467
154MP0000465_gastrointestinal_hemorrhage0.75548488
155MP0001879_abnormal_lymphatic_vessel0.75529224
156MP0003632_abnormal_nervous_system0.75401528
157MP0003787_abnormal_imprinting0.75325045
158MP0000703_abnormal_thymus_morphology0.73865794
159MP0002557_abnormal_social/conspecific_i0.73104742
160MP0002896_abnormal_bone_mineralization0.72437978
161MP0003935_abnormal_craniofacial_develop0.72294413
162MP0002184_abnormal_innervation0.72076634
163MP0003183_abnormal_peptide_metabolism0.71591542
164MP0002751_abnormal_autonomic_nervous0.71291322
165MP0008438_abnormal_cutaneous_collagen0.70549673
166MP0002066_abnormal_motor_capabilities/c0.69628492
167MP0003866_abnormal_defecation0.69303145
168MP0008961_abnormal_basal_metabolism0.69273196
169MP0001440_abnormal_grooming_behavior0.68900306
170MP0003045_fibrosis0.67601792
171MP0000534_abnormal_ureter_morphology0.67425481
172MP0003077_abnormal_cell_cycle0.65915314
173MP0001545_abnormal_hematopoietic_system0.63112866
174MP0005397_hematopoietic_system_phenotyp0.63112866

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.19182947
2Supranuclear gaze palsy (HP:0000605)3.51332553
3Eczematoid dermatitis (HP:0000976)3.16836138
4Neurofibrillary tangles (HP:0002185)3.04898656
5Upper motor neuron abnormality (HP:0002127)2.89651313
6Myokymia (HP:0002411)2.81449645
7Ankle clonus (HP:0011448)2.74791073
8Papillary thyroid carcinoma (HP:0002895)2.73749780
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.69243818
10T lymphocytopenia (HP:0005403)2.59988786
11Abnormality of T cell number (HP:0011839)2.57387761
12Elevated erythrocyte sedimentation rate (HP:0003565)2.56000480
13Onion bulb formation (HP:0003383)2.54306616
14Chronic otitis media (HP:0000389)2.53997795
15Degeneration of the lateral corticospinal tracts (HP:0002314)2.51635535
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.51635535
17Thick nail (HP:0001805)2.50886411
18Abnormality of nail color (HP:0100643)2.44999826
19Abnormality of the lower motor neuron (HP:0002366)2.41786572
20Recurrent cutaneous fungal infections (HP:0011370)2.40087513
21Chronic mucocutaneous candidiasis (HP:0002728)2.40087513
22Recurrent fungal infections (HP:0002841)2.38503546
23Mediastinal lymphadenopathy (HP:0100721)2.37842586
24Abnormality of the vasculature of the conjunctiva (HP:0008054)2.34036311
25Conjunctival telangiectasia (HP:0000524)2.31954653
26Subacute progressive viral hepatitis (HP:0006572)2.30322852
27Focal motor seizures (HP:0011153)2.25500164
28Peripheral hypomyelination (HP:0007182)2.25016796
29Widely spaced teeth (HP:0000687)2.23127299
30Dysmetria (HP:0001310)2.19355899
31Transitional cell carcinoma of the bladder (HP:0006740)2.18248488
32Recurrent abscess formation (HP:0002722)2.17963836
33Increased cerebral lipofuscin (HP:0011813)2.17736918
34Segmental peripheral demyelination/remyelination (HP:0003481)2.16815706
35Cerebral inclusion bodies (HP:0100314)2.16786208
36Uterine leiomyosarcoma (HP:0002891)2.15593856
37Leiomyosarcoma (HP:0100243)2.15593856
38Selective tooth agenesis (HP:0001592)2.15371826
39Cerebral aneurysm (HP:0004944)2.13022174
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.10803458
41Amyotrophic lateral sclerosis (HP:0007354)2.10700210
42Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.09989838
43Milia (HP:0001056)2.09703596
44Parakeratosis (HP:0001036)2.08186337
45Severe combined immunodeficiency (HP:0004430)2.06701320
46Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.05305744
47Atrophic scars (HP:0001075)2.05278508
48Arterial tortuosity (HP:0005116)2.04884204
49Bladder carcinoma (HP:0002862)2.04676099
50Bladder neoplasm (HP:0009725)2.04676099
51Thickened helices (HP:0000391)2.04012287
52Menstrual irregularities (HP:0000858)2.03072301
53Absent frontal sinuses (HP:0002688)2.02984531
54Apathy (HP:0000741)2.01315169
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00947754
56Shallow orbits (HP:0000586)2.00857930
57Spastic gait (HP:0002064)2.00312966
58Megalencephaly (HP:0001355)1.98835366
59Scanning speech (HP:0002168)1.97356241
60Diminished motivation (HP:0000745)1.97259692
61Hyperacusis (HP:0010780)1.97123291
62Epileptic encephalopathy (HP:0200134)1.97021272
63Plantar hyperkeratosis (HP:0007556)1.95373432
64Hammertoe (HP:0001765)1.95089785
65Osteolytic defects of the hand bones (HP:0009699)1.93411462
66Osteolytic defects of the phalanges of the hand (HP:0009771)1.93411462
67Thyroiditis (HP:0100646)1.92954888
68Abnormal auditory evoked potentials (HP:0006958)1.92711943
69Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.92166208
70Heterotopia (HP:0002282)1.90984398
71Lip pit (HP:0100267)1.90923676
72Natal tooth (HP:0000695)1.90540489
73Retrobulbar optic neuritis (HP:0100654)1.89466168
74Optic neuritis (HP:0100653)1.89466168
75Asymmetry of the thorax (HP:0001555)1.89077984
76Increased IgM level (HP:0003496)1.88913671
77Vascular tortuosity (HP:0004948)1.88457658
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87584430
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87567743
80Recurrent skin infections (HP:0001581)1.85965655
81Autoamputation (HP:0001218)1.85119573
82Panhypogammaglobulinemia (HP:0003139)1.85103646
83Vertebral arch anomaly (HP:0008438)1.84465822
84Macroorchidism (HP:0000053)1.84365258
85Mixed hearing impairment (HP:0000410)1.84253883
86Inappropriate behavior (HP:0000719)1.83832361
87Persistence of primary teeth (HP:0006335)1.83361812
88Palmoplantar hyperkeratosis (HP:0000972)1.82692945
89Recurrent viral infections (HP:0004429)1.82641487
90Palmar hyperkeratosis (HP:0010765)1.82300527
91Slow saccadic eye movements (HP:0000514)1.81622497
92Acute lymphatic leukemia (HP:0006721)1.81011846
93Abnormality of binocular vision (HP:0011514)1.80230225
94Diplopia (HP:0000651)1.80230225
95Disinhibition (HP:0000734)1.79059751
96Abnormality of macrophages (HP:0004311)1.78847130
97Spastic diplegia (HP:0001264)1.74094951
98Abnormality of glycolipid metabolism (HP:0010969)1.73258051
99Abnormality of liposaccharide metabolism (HP:0010968)1.73258051
100Abnormality of glycosphingolipid metabolism (HP:0004343)1.73258051
101Gastrointestinal carcinoma (HP:0002672)1.73093068
102Malignant gastrointestinal tract tumors (HP:0006749)1.73093068
103Protruding tongue (HP:0010808)1.72649140
104Progressive cerebellar ataxia (HP:0002073)1.72576030
105Clumsiness (HP:0002312)1.70527814
106Curly hair (HP:0002212)1.69935063
107Termporal pattern (HP:0011008)1.69135699
108Insidious onset (HP:0003587)1.69135699
109Fatigue (HP:0012378)1.68938039
110Action tremor (HP:0002345)1.68489863
111Renal cell carcinoma (HP:0005584)1.68402502
112Nail dystrophy (HP:0008404)1.67853829
113Abnormality of the salivary glands (HP:0010286)1.67474045
114Abnormality of the corticospinal tract (HP:0002492)1.67275074
115Neuronal loss in central nervous system (HP:0002529)1.66696053
116Genetic anticipation (HP:0003743)1.65793322
117Stereotypic behavior (HP:0000733)1.65192416
118Advanced eruption of teeth (HP:0006288)1.64374014
119Hypoplasia of the iris (HP:0007676)1.64158929
120Insomnia (HP:0100785)1.64112410
121Esophageal varix (HP:0002040)1.62778510
122Depression (HP:0000716)1.61683490
123Overgrowth (HP:0001548)1.61655570
124Recurrent bacterial skin infections (HP:0005406)1.61469299
125Retinal dysplasia (HP:0007973)1.60905210
126Focal seizures (HP:0007359)1.60818350
127Deep philtrum (HP:0002002)1.60665387
128Chronic obstructive pulmonary disease (HP:0006510)1.60491047
129Obstructive lung disease (HP:0006536)1.60491047
130Tetraparesis (HP:0002273)1.60395038
131Loss of speech (HP:0002371)1.60111188
132Mitral valve prolapse (HP:0001634)1.59675388
133Agnosia (HP:0010524)1.59428030
134Absent speech (HP:0001344)1.59165157
135Broad-based gait (HP:0002136)1.58992401
136Ankyloglossia (HP:0010296)1.58829343
137Plagiocephaly (HP:0001357)1.58761213
138Wide intermamillary distance (HP:0006610)1.58385012
139Heterochromia iridis (HP:0001100)1.58089672
140Arnold-Chiari malformation (HP:0002308)1.58005878
141Cubitus valgus (HP:0002967)1.57651332
142Ridged nail (HP:0001807)1.57077292
143Dysmetric saccades (HP:0000641)1.57068911
144Mutism (HP:0002300)1.56242510
145Anhidrosis (HP:0000970)1.55034000
146Leukocytosis (HP:0001974)1.54518916
147Akinesia (HP:0002304)1.53443285
148Pointed chin (HP:0000307)1.52650620
149Lower limb amyotrophy (HP:0007210)1.52635611
150Albinism (HP:0001022)1.52272148
151Dry hair (HP:0011359)1.52058105
152White forelock (HP:0002211)1.51608721
153Freckling (HP:0001480)1.51496328
154Stomach cancer (HP:0012126)1.50959075
155Spondylolisthesis (HP:0003302)1.50256114
156Premature rupture of membranes (HP:0001788)1.49561956
157Lower limb muscle weakness (HP:0007340)1.49524484
158Decreased lacrimation (HP:0000633)1.49192222
159Pulmonary infiltrates (HP:0002113)1.48670999
160Micronodular cirrhosis (HP:0001413)1.48584046
161Gingivitis (HP:0000230)1.48494721
162Alacrima (HP:0000522)1.48215650
163Thyroid carcinoma (HP:0002890)1.47940675
164Abnormality of the frontal sinuses (HP:0002687)1.47817735
165Germ cell neoplasia (HP:0100728)1.47555299
166Overriding aorta (HP:0002623)1.47207181
167Porencephaly (HP:0002132)1.46837519
168Progressive muscle weakness (HP:0003323)1.46049466
169Thin bony cortex (HP:0002753)1.45968115
170Ankle contracture (HP:0006466)1.45204695
171Decreased motor nerve conduction velocity (HP:0003431)1.44812599
172Broad nasal tip (HP:0000455)1.44784432
173Truncal ataxia (HP:0002078)1.44363420
174Absent septum pellucidum (HP:0001331)1.43748726
175Anteriorly placed anus (HP:0001545)1.42834536
176Ocular albinism (HP:0001107)1.41877434

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.25898980
2RIPK13.54298919
3TAOK22.94131599
4CDK122.91897470
5EPHA42.79333436
6MKNK12.72049944
7CLK12.37727382
8MAP3K142.34167247
9MAP3K32.32002936
10TXK2.27213108
11LATS22.21698595
12EPHB12.20695880
13MAP2K32.09384163
14CDK192.08356412
15PRPF4B2.02966564
16STK241.95377293
17RIPK41.93576356
18TRIB31.92012272
19MAP3K131.89229991
20PDGFRA1.87069374
21NTRK31.83870143
22JAK31.83325978
23MAP3K111.74623145
24MAP3K101.69086796
25BCR1.67673895
26MARK21.64424226
27DMPK1.63292571
28CAMK1D1.63210489
29MAP4K11.62904659
30CDK61.52885786
31KSR21.49871850
32UHMK11.43478657
33SIK21.42046771
34FES1.39784893
35KSR11.36396222
36PKN21.34942219
37MARK11.34161429
38PKN11.33115104
39MAP3K91.32728775
40STK391.31211331
41IKBKE1.27838379
42SIK31.26841702
43NTRK21.25739911
44MAPKAPK51.23642733
45IRAK31.22614787
46YES11.21836949
47FGR1.21035319
48BMPR21.18561183
49SMG11.18240495
50PRKCH1.17961273
51CDK51.16913203
52PTK21.16753075
53TNIK1.15257685
54BRD41.15025244
55CASK1.14773048
56OXSR11.13890623
57SGK31.13225058
58TBK11.12433428
59MET1.12071815
60DAPK21.11229445
61ICK1.08702447
62EEF2K1.08612246
63NTRK11.05678102
64PAK61.05077480
65NEK61.02265900
66MAP3K51.01497329
67ZAP701.01355808
68MAP3K11.01229722
69LIMK11.00865981
70LCK1.00230623
71SGK20.99005674
72ITK0.98578486
73WNK10.98333990
74HIPK20.98066070
75SGK2230.97431302
76SGK4940.97431302
77TYRO30.97390562
78DYRK1A0.96370933
79PRKCQ0.95581312
80SIK10.95411190
81BLK0.95237735
82NEK90.94280191
83PRKD30.93861368
84TGFBR20.92808000
85HCK0.91493636
86FGFR40.90795726
87IKBKB0.90471941
88CSNK1A1L0.89573977
89MTOR0.88211029
90EPHA30.87427736
91FYN0.86537712
92KIT0.84959094
93ROCK20.84231697
94CAMK2B0.82410557
95FGFR20.81348592
96MINK10.80460100
97CHUK0.78988360
98BRAF0.76073702
99RET0.75851958
100MAP3K80.75695553
101PDGFRB0.74847877
102JAK10.74586844
103PTK60.74292355
104MAP3K20.73410075
105LATS10.72611727
106PLK20.72257367
107MAP3K70.70475101
108DDR20.70344149
109RAF10.66614395
110MARK30.66556592
111MOS0.66395653
112IRAK10.65966047
113MELK0.65164898
114ARAF0.64593873
115MAPK130.64023303
116PAK40.63606157
117RPS6KB10.63166265
118CDK140.62530158
119CSK0.61740478
120TAOK10.61589689
121FGFR10.59379900
122SYK0.59361938
123CAMK1G0.58241507
124STK30.58175623
125CAMK10.57339925
126EPHB20.55978920
127INSR0.53715086
128CSNK1G20.53539923
129ABL20.53006218
130SGK10.52088820
131JAK20.51942205
132IRAK20.51322137
133TGFBR10.51119973
134RPS6KB20.49097980
135CDK180.49012166
136STK38L0.48846398
137IRAK40.48265986
138CAMKK10.48070135
139ALK0.47724328
140FGFR30.47446934
141CDK150.47403444
142PDK10.46924254
143PDPK10.46695348
144ERBB40.46564538
145CDK90.45478223
146CAMK2A0.45464151
147RPS6KA20.45459997
148PRKCE0.45225063
149TNK20.44774522
150CDC42BPA0.42247458
151CAMKK20.38567045
152TTN0.38245829
153BMX0.35865391
154TTK0.31853927
155MAPK100.28307603
156PNCK0.26645870
157MATK0.26507789
158CSF1R0.25033687

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052161.70000420
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68796309
3Non-small cell lung cancer_Homo sapiens_hsa052231.67520079
4T cell receptor signaling pathway_Homo sapiens_hsa046601.51006096
5MicroRNAs in cancer_Homo sapiens_hsa052061.45394139
6Adherens junction_Homo sapiens_hsa045201.42808055
7Morphine addiction_Homo sapiens_hsa050321.39458483
8Leishmaniasis_Homo sapiens_hsa051401.38401303
9Amoebiasis_Homo sapiens_hsa051461.36900790
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.35816622
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31768609
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31431847
13Circadian entrainment_Homo sapiens_hsa047131.28606226
14Allograft rejection_Homo sapiens_hsa053301.28584471
15Osteoclast differentiation_Homo sapiens_hsa043801.27844842
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27736965
17Axon guidance_Homo sapiens_hsa043601.26740545
18Graft-versus-host disease_Homo sapiens_hsa053321.26206237
19mTOR signaling pathway_Homo sapiens_hsa041501.25126261
20Proteoglycans in cancer_Homo sapiens_hsa052051.25051619
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24554005
22Chemokine signaling pathway_Homo sapiens_hsa040621.23719389
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23592726
24Primary immunodeficiency_Homo sapiens_hsa053401.21875219
25Notch signaling pathway_Homo sapiens_hsa043301.21440387
26Glutamatergic synapse_Homo sapiens_hsa047241.21203375
27Estrogen signaling pathway_Homo sapiens_hsa049151.20565748
28Long-term potentiation_Homo sapiens_hsa047201.20109115
29Inositol phosphate metabolism_Homo sapiens_hsa005621.18444861
30Olfactory transduction_Homo sapiens_hsa047401.18076329
31Cocaine addiction_Homo sapiens_hsa050301.17286406
32Bladder cancer_Homo sapiens_hsa052191.16887297
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16344349
34Type I diabetes mellitus_Homo sapiens_hsa049401.15586437
35Prostate cancer_Homo sapiens_hsa052151.13772911
36Synaptic vesicle cycle_Homo sapiens_hsa047211.11754454
37Cholinergic synapse_Homo sapiens_hsa047251.11259360
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11107139
39TNF signaling pathway_Homo sapiens_hsa046681.10883270
40Rheumatoid arthritis_Homo sapiens_hsa053231.10009667
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09641473
42B cell receptor signaling pathway_Homo sapiens_hsa046621.09318139
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09103970
44Long-term depression_Homo sapiens_hsa047301.08276722
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.07885251
46Focal adhesion_Homo sapiens_hsa045101.06599110
47Dopaminergic synapse_Homo sapiens_hsa047281.06354109
48GABAergic synapse_Homo sapiens_hsa047271.05929500
49Sphingolipid signaling pathway_Homo sapiens_hsa040711.05768115
50Nicotine addiction_Homo sapiens_hsa050331.05066870
51Salmonella infection_Homo sapiens_hsa051321.04455270
52Prion diseases_Homo sapiens_hsa050201.04051067
53Shigellosis_Homo sapiens_hsa051311.03765156
54Small cell lung cancer_Homo sapiens_hsa052221.02114183
55Malaria_Homo sapiens_hsa051440.98766569
56Renin secretion_Homo sapiens_hsa049240.98617278
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98411946
58Renal cell carcinoma_Homo sapiens_hsa052110.98328674
59ErbB signaling pathway_Homo sapiens_hsa040120.97529413
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96741298
61Amphetamine addiction_Homo sapiens_hsa050310.96633402
62Autoimmune thyroid disease_Homo sapiens_hsa053200.96409146
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96149600
64Serotonergic synapse_Homo sapiens_hsa047260.96098492
65Tuberculosis_Homo sapiens_hsa051520.95968663
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.95504758
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94960503
68Asthma_Homo sapiens_hsa053100.94907326
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93093672
70Measles_Homo sapiens_hsa051620.92845816
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.92226200
72Endocytosis_Homo sapiens_hsa041440.91666364
73HIF-1 signaling pathway_Homo sapiens_hsa040660.89926156
74Pertussis_Homo sapiens_hsa051330.89335290
75Toxoplasmosis_Homo sapiens_hsa051450.88704719
76Dorso-ventral axis formation_Homo sapiens_hsa043200.88532916
77VEGF signaling pathway_Homo sapiens_hsa043700.88091608
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87473161
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86962938
80cAMP signaling pathway_Homo sapiens_hsa040240.86879298
81Salivary secretion_Homo sapiens_hsa049700.86566206
82Chronic myeloid leukemia_Homo sapiens_hsa052200.86203463
83FoxO signaling pathway_Homo sapiens_hsa040680.86133577
84MAPK signaling pathway_Homo sapiens_hsa040100.86011728
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85952782
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85816481
87Gastric acid secretion_Homo sapiens_hsa049710.85794847
88Oxytocin signaling pathway_Homo sapiens_hsa049210.84948282
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.84654266
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83167534
91Apoptosis_Homo sapiens_hsa042100.82750369
92Cell cycle_Homo sapiens_hsa041100.82355819
93Ras signaling pathway_Homo sapiens_hsa040140.82225920
94Insulin signaling pathway_Homo sapiens_hsa049100.80579252
95Glioma_Homo sapiens_hsa052140.80374816
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80328946
97Acute myeloid leukemia_Homo sapiens_hsa052210.80278507
98African trypanosomiasis_Homo sapiens_hsa051430.79754592
99Melanogenesis_Homo sapiens_hsa049160.78872174
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78787055
101Rap1 signaling pathway_Homo sapiens_hsa040150.78613168
102Pancreatic cancer_Homo sapiens_hsa052120.78183603
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77957640
104Colorectal cancer_Homo sapiens_hsa052100.77144774
105Prolactin signaling pathway_Homo sapiens_hsa049170.77007207
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76640162
107Type II diabetes mellitus_Homo sapiens_hsa049300.76503781
108GnRH signaling pathway_Homo sapiens_hsa049120.76098550
109Hematopoietic cell lineage_Homo sapiens_hsa046400.75890068
110ECM-receptor interaction_Homo sapiens_hsa045120.75829142
111Influenza A_Homo sapiens_hsa051640.75355109
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74700887
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.74687698
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.74498198
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73741889
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.73640058
117Insulin secretion_Homo sapiens_hsa049110.73593738
118Lysosome_Homo sapiens_hsa041420.73474643
119Gap junction_Homo sapiens_hsa045400.73436169
120Melanoma_Homo sapiens_hsa052180.73238727
121Vibrio cholerae infection_Homo sapiens_hsa051100.73171198
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72941385
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72611307
124Hepatitis C_Homo sapiens_hsa051600.72246910
125Pathways in cancer_Homo sapiens_hsa052000.71757923
126Viral carcinogenesis_Homo sapiens_hsa052030.71097687
127Viral myocarditis_Homo sapiens_hsa054160.69680855
128Phagosome_Homo sapiens_hsa041450.69164418
129Platelet activation_Homo sapiens_hsa046110.68876924
130Choline metabolism in cancer_Homo sapiens_hsa052310.68688246
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67927478
132Hepatitis B_Homo sapiens_hsa051610.67505447
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66385908
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66146452
135Hippo signaling pathway_Homo sapiens_hsa043900.64266821
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64218126
137Endometrial cancer_Homo sapiens_hsa052130.64000900
138Oocyte meiosis_Homo sapiens_hsa041140.62973125
139AMPK signaling pathway_Homo sapiens_hsa041520.60481380
140TGF-beta signaling pathway_Homo sapiens_hsa043500.60467785
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60089130
142mRNA surveillance pathway_Homo sapiens_hsa030150.59681428
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57381422

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