STX7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.62176269
2* synaptic vesicle exocytosis (GO:0016079)4.20975120
3neuron cell-cell adhesion (GO:0007158)4.10514988
4regulation of B cell receptor signaling pathway (GO:0050855)4.02422594
5regulation of synaptic vesicle exocytosis (GO:2000300)4.01023083
6detection of molecule of bacterial origin (GO:0032490)3.83138240
7microglial cell activation (GO:0001774)3.81432904
8synaptic vesicle maturation (GO:0016188)3.77435273
9interkinetic nuclear migration (GO:0022027)3.76982758
10B cell receptor signaling pathway (GO:0050853)3.68109801
11protein localization to synapse (GO:0035418)3.64798883
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.62078781
13positive regulation of gamma-delta T cell activation (GO:0046645)3.58622522
14vocalization behavior (GO:0071625)3.54383773
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.43232310
16layer formation in cerebral cortex (GO:0021819)3.41045813
17phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.34594579
18positive regulation of mast cell activation (GO:0033005)3.34149913
19regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.34140645
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.32330711
21regulation of synaptic vesicle transport (GO:1902803)3.31724192
22negative regulation of cell killing (GO:0031342)3.31389005
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31389005
24macrophage activation involved in immune response (GO:0002281)3.30483789
25modulation by symbiont of host immune response (GO:0052553)3.29712615
26positive regulation by symbiont of host defense response (GO:0052509)3.29712615
27modulation by symbiont of host defense response (GO:0052031)3.29712615
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29712615
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29712615
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.29712615
31positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.28825245
32neutrophil activation (GO:0042119)3.28221425
33regulation of pigment cell differentiation (GO:0050932)3.27315024
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26900982
35glutamate secretion (GO:0014047)3.26834603
36tyrosine phosphorylation of STAT protein (GO:0007260)3.20756918
37locomotory exploration behavior (GO:0035641)3.18698831
38regulation of synapse structural plasticity (GO:0051823)3.14199087
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12355778
40neural tube formation (GO:0001841)3.10614771
41energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10392701
42ATP hydrolysis coupled proton transport (GO:0015991)3.10392701
43phagosome maturation (GO:0090382)3.09013697
44neuron recognition (GO:0008038)3.07875386
45transferrin transport (GO:0033572)3.04096986
46cellular potassium ion homeostasis (GO:0030007)3.03867695
47detection of external biotic stimulus (GO:0098581)3.01019798
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99633172
49detection of other organism (GO:0098543)2.99415803
50regulation of glutamate receptor signaling pathway (GO:1900449)2.97865023
51activated T cell proliferation (GO:0050798)2.97211456
52proline transport (GO:0015824)2.97172893
53postsynaptic membrane organization (GO:0001941)2.96744898
54regulation of mast cell activation (GO:0033003)2.93202480
55exploration behavior (GO:0035640)2.92874307
56positive regulation of mast cell activation involved in immune response (GO:0033008)2.92658565
57positive regulation of mast cell degranulation (GO:0043306)2.92658565
58positive regulation of cellular amide metabolic process (GO:0034250)2.88205459
59cellular extravasation (GO:0045123)2.84609143
60neutrophil mediated immunity (GO:0002446)2.84401820
61presynaptic membrane assembly (GO:0097105)2.84304588
62neurotransmitter secretion (GO:0007269)2.83763758
63trivalent inorganic cation transport (GO:0072512)2.82200777
64ferric iron transport (GO:0015682)2.82200777
65ionotropic glutamate receptor signaling pathway (GO:0035235)2.81786921
66neurotransmitter-gated ion channel clustering (GO:0072578)2.81444199
67macrophage activation (GO:0042116)2.80534675
68granulocyte activation (GO:0036230)2.80347807
69negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.77210284
70vesicle transport along microtubule (GO:0047496)2.77105276
71dendrite morphogenesis (GO:0048813)2.76818355
72clathrin coat assembly (GO:0048268)2.75267463
73neuronal action potential propagation (GO:0019227)2.74004481
74myeloid leukocyte mediated immunity (GO:0002444)2.69310029
75presynaptic membrane organization (GO:0097090)2.69036862
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68129987
77axonal fasciculation (GO:0007413)2.67969531
78negative regulation of microtubule polymerization (GO:0031115)2.67458148
79myeloid cell activation involved in immune response (GO:0002275)2.67386290
80negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66887360
81negative regulation of immunoglobulin mediated immune response (GO:0002890)2.63618398
82negative regulation of B cell mediated immunity (GO:0002713)2.63618398
83regulation of amyloid precursor protein catabolic process (GO:1902991)2.62016327
84regulation of mast cell activation involved in immune response (GO:0033006)2.61760590
85antigen processing and presentation of endogenous antigen (GO:0019883)2.61713773
86mating behavior (GO:0007617)2.59568095
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59511421
88regulation of vesicle fusion (GO:0031338)2.59085077
89glutamate receptor signaling pathway (GO:0007215)2.58107066
90synaptic vesicle endocytosis (GO:0048488)2.56734179
91developmental pigmentation (GO:0048066)2.56543036
92sodium ion export (GO:0071436)2.55225539
93leukocyte migration involved in inflammatory response (GO:0002523)2.54441716
94gamma-aminobutyric acid signaling pathway (GO:0007214)2.53873262
95synaptic vesicle docking involved in exocytosis (GO:0016081)2.53476463
96negative regulation of lymphocyte mediated immunity (GO:0002707)2.51448641
97detection of bacterium (GO:0016045)2.51221552
98pyrimidine nucleobase catabolic process (GO:0006208)2.50577315
99long-term synaptic potentiation (GO:0060291)2.50548608
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.50470704
101organelle transport along microtubule (GO:0072384)2.50352285
102nerve growth factor signaling pathway (GO:0038180)2.49474657
103synapse assembly (GO:0007416)2.44558273
104* establishment of synaptic vesicle localization (GO:0097480)2.43926226
105* synaptic vesicle transport (GO:0048489)2.43926226
106parental behavior (GO:0060746)2.43904481
107detection of biotic stimulus (GO:0009595)2.43868642
108* establishment of vesicle localization (GO:0051650)2.43407313
109detection of temperature stimulus involved in sensory perception (GO:0050961)2.43297800
110detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.43297800
111neurotransmitter transport (GO:0006836)2.43132101
112regulation of beta-amyloid formation (GO:1902003)2.43085506
113protein targeting to vacuole (GO:0006623)2.43029736
114protein targeting to lysosome (GO:0006622)2.43029736
115establishment of protein localization to vacuole (GO:0072666)2.43029736
116sialylation (GO:0097503)2.42598829
117regulation of mast cell degranulation (GO:0043304)2.42541891
118positive regulation of macrophage cytokine production (GO:0060907)2.40464933
119regulation of neuronal synaptic plasticity (GO:0048168)2.40301749
120maternal behavior (GO:0042711)2.40044562
121interferon-gamma-mediated signaling pathway (GO:0060333)2.38232859
122nucleobase catabolic process (GO:0046113)2.37907100
123negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.36918239
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.36302739
125nucleus localization (GO:0051647)2.35617287
126positive regulation of interleukin-1 beta secretion (GO:0050718)2.35104396
127regulation of neurotransmitter secretion (GO:0046928)2.34914838
128regulation of interleukin-6 biosynthetic process (GO:0045408)2.34817137
129regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.34191992
130neuron-neuron synaptic transmission (GO:0007270)2.33925210
131positive regulation of membrane potential (GO:0045838)2.33745684
132growth hormone receptor signaling pathway (GO:0060396)2.33608111
133regulation of excitatory postsynaptic membrane potential (GO:0060079)2.32881930
134negative regulation of neurotransmitter transport (GO:0051589)2.31997772
135positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.31362991
136positive regulation of synaptic transmission, GABAergic (GO:0032230)2.31260357
137regulation of MHC class II biosynthetic process (GO:0045346)2.31226905
138antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.31084766
139positive regulation of synapse maturation (GO:0090129)2.30810120
140neutrophil activation involved in immune response (GO:0002283)2.30727165
141negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.30521718
142cellular response to ethanol (GO:0071361)2.30457510
143axon cargo transport (GO:0008088)2.29121330
144positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.28629269
145response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.28597251
146response to host immune response (GO:0052572)2.28597251
147regulation of long-term neuronal synaptic plasticity (GO:0048169)2.27941989
148negative regulation of exocytosis (GO:0045920)2.27760932
149positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.27368811
150response to auditory stimulus (GO:0010996)2.27127392
151positive regulation of granulocyte differentiation (GO:0030854)2.26729455
152innervation (GO:0060384)2.25736291
153synaptic transmission, glutamatergic (GO:0035249)2.25637790
154negative regulation of mast cell activation (GO:0033004)2.25126125
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.25031256
156regulation of interferon-beta biosynthetic process (GO:0045357)2.24939827
157positive regulation of interleukin-1 production (GO:0032732)2.24371670
158regulation of gamma-delta T cell activation (GO:0046643)2.24282255
159regulation of dendritic spine morphogenesis (GO:0061001)2.24199465
160negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.23993267
161negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.22639512
162regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.22547291
163negative regulation of interleukin-17 production (GO:0032700)2.22306097
164regulation of neurotransmitter levels (GO:0001505)2.21953378
165regulation of postsynaptic membrane potential (GO:0060078)2.21571547
166regulation of mitochondrial depolarization (GO:0051900)2.21236604
167activation of protein kinase A activity (GO:0034199)2.20449529
168positive regulation of interleukin-1 beta production (GO:0032731)2.20079902
169T-helper 1 type immune response (GO:0042088)2.19877756
170positive regulation of interleukin-1 secretion (GO:0050716)2.19716980
171melanin metabolic process (GO:0006582)2.19479116
172regulation of synaptic plasticity (GO:0048167)2.17667629
173dendrite development (GO:0016358)2.17583569
174mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.16875365
175positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.16875365
176peptide catabolic process (GO:0043171)2.16780782
177response to nerve growth factor (GO:1990089)2.16364002
178cellular response to nerve growth factor stimulus (GO:1990090)2.16364002
179regulation of exocytosis (GO:0017157)2.16236299
180cerebellar granule cell differentiation (GO:0021707)2.15609935
181regulation of antigen processing and presentation (GO:0002577)2.15485602
182positive regulation of synapse assembly (GO:0051965)2.15094624
183regulation of voltage-gated calcium channel activity (GO:1901385)2.14512839
184positive regulation of potassium ion transmembrane transport (GO:1901381)2.13946642
185negative regulation of neurotransmitter secretion (GO:0046929)2.13674750
186positive regulation of exocytosis (GO:0045921)2.13402214
187regulation of neurotransmitter transport (GO:0051588)2.11235588
188membrane assembly (GO:0071709)2.08373187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.65407663
2GBX2_23144817_ChIP-Seq_PC3_Human3.23359108
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85089082
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66431579
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56524066
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44186716
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.43406645
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37400024
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33551920
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28761259
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28524801
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24080203
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24080203
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21518326
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.08923971
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07825457
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07746762
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05799155
19REST_21632747_ChIP-Seq_MESCs_Mouse2.00406092
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96772539
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.92973753
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.87512480
23TAF15_26573619_Chip-Seq_HEK293_Human1.83799485
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.79567754
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78287964
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77872792
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77563870
28DROSHA_22980978_ChIP-Seq_HELA_Human1.75166270
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75151045
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74703048
31AR_21572438_ChIP-Seq_LNCaP_Human1.72137351
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67984135
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.66498286
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65265626
35IGF1R_20145208_ChIP-Seq_DFB_Human1.65214036
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64753337
37FUS_26573619_Chip-Seq_HEK293_Human1.63859752
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.61966182
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61601486
40GATA1_22025678_ChIP-Seq_K562_Human1.59428086
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58251009
42SMAD4_21799915_ChIP-Seq_A2780_Human1.56733416
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56113371
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55736296
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53590476
46P300_19829295_ChIP-Seq_ESCs_Human1.52790874
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.51616614
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.51040931
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51023605
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.47155946
51RUNX_20019798_ChIP-Seq_JUKART_Human1.44382231
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44106114
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43412162
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.40969602
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40112934
56* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36184245
57TP53_16413492_ChIP-PET_HCT116_Human1.34610464
58AR_25329375_ChIP-Seq_VCAP_Human1.33636634
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33519631
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.33513248
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33042328
62ZNF274_21170338_ChIP-Seq_K562_Hela1.33008988
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32740590
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32740590
65ER_23166858_ChIP-Seq_MCF-7_Human1.32374670
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.30282694
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29827726
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28707660
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.28287340
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28113141
71* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26864611
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25776967
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.25136442
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24563057
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24540546
76* FLI1_21867929_ChIP-Seq_TH2_Mouse1.23765818
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23056582
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20470726
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.20276359
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19951523
81P53_22387025_ChIP-Seq_ESCs_Mouse1.19581121
82TP53_18474530_ChIP-ChIP_U2OS_Human1.19350539
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18039016
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18039016
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17970109
86KDM2B_26808549_Chip-Seq_REH_Human1.17835601
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16865835
88VDR_22108803_ChIP-Seq_LS180_Human1.16431572
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16216195
90CBP_20019798_ChIP-Seq_JUKART_Human1.16216195
91TAL1_26923725_Chip-Seq_HPCs_Mouse1.16096157
92* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15563988
93SCL_19346495_ChIP-Seq_HPC-7_Human1.15120132
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.14844534
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.13488380
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.13353795
97AHR_22903824_ChIP-Seq_MCF-7_Human1.11443202
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11319670
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10968888
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.10700712
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.10512226
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10450704
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.10199954
104* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10048793
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09902447
106EWS_26573619_Chip-Seq_HEK293_Human1.09418423
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.08243945
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.08085873
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07873166
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07853310
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06953445
112* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06843929
113STAT3_23295773_ChIP-Seq_U87_Human1.06036884
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04685487
115* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04055513
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03567397
117JUN_21703547_ChIP-Seq_K562_Human1.03533066
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02989600
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02297120
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01817128
121* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01451189
122CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00870114
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00326556
124* CRX_20693478_ChIP-Seq_RETINA_Mouse1.00190454
125* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99698738
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99599849
127FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98804547
128P300_18555785_Chip-Seq_ESCs_Mouse0.98019152
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96971441
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95747976
131RUNX2_22187159_ChIP-Seq_PCA_Human0.94881632
132* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94562661
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.94480387
134RNF2_27304074_Chip-Seq_NSC_Mouse0.94290953
135* IRF8_27001747_Chip-Seq_BMDM_Mouse0.94042720
136RING1B_27294783_Chip-Seq_ESCs_Mouse0.92467426
137RXR_22108803_ChIP-Seq_LS180_Human0.92388831
138* TCF4_23295773_ChIP-Seq_U87_Human0.90804210
139VDR_24787735_ChIP-Seq_THP-1_Human0.90667965
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.89435472
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88449992
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88323730
143SOX2_20726797_ChIP-Seq_SW620_Human0.88285295
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88023827
145BCAT_22108803_ChIP-Seq_LS180_Human0.86775232
146NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86575073
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85959869
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.85793188
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.85526353
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.85060239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.00612472
2MP0003724_increased_susceptibility_to3.65660277
3MP0003880_abnormal_central_pattern3.65371992
4MP0004270_analgesia3.57040930
5MP0005174_abnormal_tail_pigmentation3.09861629
6MP0003635_abnormal_synaptic_transmissio2.96300176
7MP0002734_abnormal_mechanical_nocicepti2.74932712
8MP0002735_abnormal_chemical_nociception2.72462860
9MP0001968_abnormal_touch/_nociception2.67719034
10MP0002064_seizures2.54046502
11MP0002063_abnormal_learning/memory/cond2.47496907
12MP0003183_abnormal_peptide_metabolism2.47175085
13MP0003787_abnormal_imprinting2.39070929
14MP0009745_abnormal_behavioral_response2.36159282
15MP0002736_abnormal_nociception_after2.35555681
16MP0005075_abnormal_melanosome_morpholog2.32408959
17MP0009046_muscle_twitch2.29670321
18MP0002733_abnormal_thermal_nociception2.22253166
19MP0004858_abnormal_nervous_system2.20694248
20MP0009780_abnormal_chondrocyte_physiolo2.20522412
21MP0003329_amyloid_beta_deposits2.17768433
22MP0001970_abnormal_pain_threshold2.07832145
23MP0002572_abnormal_emotion/affect_behav2.06749917
24MP0002095_abnormal_skin_pigmentation2.00127932
25MP0005058_abnormal_lysosome_morphology1.96681134
26MP0005423_abnormal_somatic_nervous1.96381857
27MP0010386_abnormal_urinary_bladder1.95375611
28MP0005464_abnormal_platelet_physiology1.92280568
29MP0002272_abnormal_nervous_system1.91886549
30MP0006276_abnormal_autonomic_nervous1.89744642
31MP0001188_hyperpigmentation1.88681086
32MP0002909_abnormal_adrenal_gland1.84761987
33MP0003172_abnormal_lysosome_physiology1.83833652
34MP0001440_abnormal_grooming_behavior1.80462702
35MP0000465_gastrointestinal_hemorrhage1.77750044
36MP0005645_abnormal_hypothalamus_physiol1.77381682
37MP0002067_abnormal_sensory_capabilities1.76996118
38MP0001486_abnormal_startle_reflex1.76927725
39MP0001800_abnormal_humoral_immune1.76847882
40MP0004883_abnormal_blood_vessel1.76273873
41MP0001501_abnormal_sleep_pattern1.74398946
42MP0000604_amyloidosis1.70465372
43MP0003879_abnormal_hair_cell1.69756395
44MP0000920_abnormal_myelination1.67418914
45MP0000778_abnormal_nervous_system1.65474387
46MP0002184_abnormal_innervation1.62025603
47MP0002009_preneoplasia1.61812464
48MP0003122_maternal_imprinting1.61556561
49MP0005409_darkened_coat_color1.59049358
50MP0003690_abnormal_glial_cell1.56275496
51MP0002090_abnormal_vision1.55988450
52MP0002876_abnormal_thyroid_physiology1.55541073
53MP0005171_absent_coat_pigmentation1.55119344
54MP0003634_abnormal_glial_cell1.54798621
55MP0000371_diluted_coat_color1.51729048
56MP0003303_peritoneal_inflammation1.48257037
57MP0004381_abnormal_hair_follicle1.46157624
58MP0003828_pulmonary_edema1.45299838
59MP0004811_abnormal_neuron_physiology1.43408104
60MP0005408_hypopigmentation1.42798475
61MP0000372_irregular_coat_pigmentation1.42328579
62MP0002557_abnormal_social/conspecific_i1.38783518
63MP0002452_abnormal_antigen_presenting1.38484299
64MP0005387_immune_system_phenotype1.36806136
65MP0001790_abnormal_immune_system1.36806136
66MP0005167_abnormal_blood-brain_barrier1.35826920
67MP0004510_myositis1.33330068
68MP0004742_abnormal_vestibular_system1.33237090
69MP0009764_decreased_sensitivity_to1.32874781
70MP0005671_abnormal_response_to1.31537516
71MP0000013_abnormal_adipose_tissue1.29221810
72MP0004885_abnormal_endolymph1.28739059
73MP0004043_abnormal_pH_regulation1.28210094
74MP0002723_abnormal_immune_serum1.27823134
75MP0008569_lethality_at_weaning1.26809957
76MP0006054_spinal_hemorrhage1.25730810
77MP0002928_abnormal_bile_duct1.24980639
78MP0004924_abnormal_behavior1.24270840
79MP0005386_behavior/neurological_phenoty1.24270840
80MP0000955_abnormal_spinal_cord1.23674459
81MP0005310_abnormal_salivary_gland1.23334406
82MP0002882_abnormal_neuron_morphology1.21493610
83MP0001851_eye_inflammation1.19307018
84MP0003633_abnormal_nervous_system1.17932538
85MP0002420_abnormal_adaptive_immunity1.17717676
86MP0002066_abnormal_motor_capabilities/c1.16642496
87MP0003075_altered_response_to1.15964254
88MP0001348_abnormal_lacrimal_gland1.15379359
89MP0001819_abnormal_immune_cell1.15239936
90MP0001905_abnormal_dopamine_level1.14977258
91MP0003656_abnormal_erythrocyte_physiolo1.14933716
92MP0002229_neurodegeneration1.14523854
93MP0009785_altered_susceptibility_to1.09190254
94MP0001984_abnormal_olfaction1.08408540
95MP0003121_genomic_imprinting1.07821779
96MP0001879_abnormal_lymphatic_vessel1.06982816
97MP0001502_abnormal_circadian_rhythm1.06498404
98MP0005025_abnormal_response_to1.05644446
99MP0001529_abnormal_vocalization1.05606223
100MP0003221_abnormal_cardiomyocyte_apopto1.05370790
101MP0005646_abnormal_pituitary_gland1.03422898
102MP0008260_abnormal_autophagy1.01879654
103MP0000569_abnormal_digit_pigmentation1.00521634
104MP0001324_abnormal_eye_pigmentation0.99314679
105MP0002163_abnormal_gland_morphology0.97615016
106MP0003631_nervous_system_phenotype0.95359808
107MP0002075_abnormal_coat/hair_pigmentati0.95025239
108MP0005397_hematopoietic_system_phenotyp0.94713014
109MP0001545_abnormal_hematopoietic_system0.94713014
110MP0005535_abnormal_body_temperature0.93997739
111MP0003436_decreased_susceptibility_to0.92476364
112MP0005248_abnormal_Harderian_gland0.91888875
113MP0001986_abnormal_taste_sensitivity0.89345335
114MP0001963_abnormal_hearing_physiology0.88991166
115MP0004142_abnormal_muscle_tone0.87591225
116MP0002837_dystrophic_cardiac_calcinosis0.87532160
117MP0000685_abnormal_immune_system0.85897376
118MP0005164_abnormal_response_to0.85295165
119MP0000681_abnormal_thyroid_gland0.84478598
120MP0005379_endocrine/exocrine_gland_phen0.83924495
121MP0001186_pigmentation_phenotype0.83878110
122MP0002405_respiratory_system_inflammati0.83741808
123MP0005084_abnormal_gallbladder_morpholo0.83256963
124MP0000716_abnormal_immune_system0.82703132
125MP0001664_abnormal_digestion0.82462410
126MP0000343_altered_response_to0.80763618
127MP0002069_abnormal_eating/drinking_beha0.80236306
128MP0002148_abnormal_hypersensitivity_rea0.80123855
129MP0001835_abnormal_antigen_presentation0.79881137
130MP0005253_abnormal_eye_physiology0.79057072
131MP0006082_CNS_inflammation0.78903791
132MP0000689_abnormal_spleen_morphology0.78817889
133MP0002998_abnormal_bone_remodeling0.78563424
134MP0004130_abnormal_muscle_cell0.78025058
135MP0000538_abnormal_urinary_bladder0.74744347
136MP0002638_abnormal_pupillary_reflex0.73991858
137MP0010234_abnormal_vibrissa_follicle0.73813740
138MP0001765_abnormal_ion_homeostasis0.72653747
139MP0005551_abnormal_eye_electrophysiolog0.72072836
140MP0003632_abnormal_nervous_system0.71867084
141MP0002152_abnormal_brain_morphology0.69389278
142MP0002419_abnormal_innate_immunity0.63547268
143MP0001756_abnormal_urination0.63196609
144MP0005000_abnormal_immune_tolerance0.62988499
145MP0008004_abnormal_stomach_pH0.61736928
146MP0000751_myopathy0.61585549
147MP0002752_abnormal_somatic_nervous0.61433498
148MP0005166_decreased_susceptibility_to0.61234942
149MP0000015_abnormal_ear_pigmentation0.60636169
150MP0008874_decreased_physiological_sensi0.59645785
151MP0004484_altered_response_of0.59446200
152MP0002822_catalepsy0.59375771
153MP0001958_emphysema0.58787449
154MP0001485_abnormal_pinna_reflex0.58121165

Predicted human phenotypes

RankGene SetZ-score
1Supranuclear gaze palsy (HP:0000605)4.48599663
2Mutism (HP:0002300)4.26926273
3Focal motor seizures (HP:0011153)4.23894146
4Neurofibrillary tangles (HP:0002185)4.22767709
5Myokymia (HP:0002411)4.15405933
6Visual hallucinations (HP:0002367)3.94388028
7Increased cerebral lipofuscin (HP:0011813)3.91701875
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.62750099
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.54190961
10Atonic seizures (HP:0010819)3.52315946
11Pheochromocytoma (HP:0002666)3.50960125
12Cerebral inclusion bodies (HP:0100314)3.48214125
13Focal seizures (HP:0007359)3.41532418
14Dysostosis multiplex (HP:0000943)3.37454298
15Neuroendocrine neoplasm (HP:0100634)3.24819407
16Spontaneous hematomas (HP:0007420)3.22774217
17Papilledema (HP:0001085)3.18139163
18Epileptic encephalopathy (HP:0200134)3.17968543
19Gingival bleeding (HP:0000225)3.16949376
20Gastrointestinal infarctions (HP:0005244)3.07013872
21Akinesia (HP:0002304)3.04166751
22Papillary thyroid carcinoma (HP:0002895)3.02623034
23Peritonitis (HP:0002586)2.97463185
24Polyphagia (HP:0002591)2.95413913
25Ankle clonus (HP:0011448)2.95234500
26Conjunctival telangiectasia (HP:0000524)2.92500596
27Prolonged bleeding time (HP:0003010)2.89087059
28Abnormality of glycolipid metabolism (HP:0010969)2.88975946
29Abnormality of liposaccharide metabolism (HP:0010968)2.88975946
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.88975946
31Abnormality of the vasculature of the conjunctiva (HP:0008054)2.88602759
32Progressive inability to walk (HP:0002505)2.88439106
33Absence seizures (HP:0002121)2.88292234
34Generalized tonic-clonic seizures (HP:0002069)2.81959183
35Dialeptic seizures (HP:0011146)2.77700968
36Abnormality of binocular vision (HP:0011514)2.74757764
37Diplopia (HP:0000651)2.74757764
38Mucopolysacchariduria (HP:0008155)2.70531472
39Urinary glycosaminoglycan excretion (HP:0003541)2.70531472
40Abnormal eating behavior (HP:0100738)2.70094566
41Amyotrophic lateral sclerosis (HP:0007354)2.69470536
42Apathy (HP:0000741)2.65941000
43Action tremor (HP:0002345)2.63963492
44Heterochromia iridis (HP:0001100)2.63906836
45Limb dystonia (HP:0002451)2.61429719
46Choroideremia (HP:0001139)2.60596569
47Diminished motivation (HP:0000745)2.57224362
48Ocular albinism (HP:0001107)2.55280422
49Neuronal loss in central nervous system (HP:0002529)2.54369744
50Generalized hypopigmentation (HP:0007513)2.51995050
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49306565
52Abnormality of polysaccharide metabolism (HP:0011012)2.49306565
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49306565
54Increased circulating renin level (HP:0000848)2.49199867
55Chronic mucocutaneous candidiasis (HP:0002728)2.47850079
56Recurrent cutaneous fungal infections (HP:0011370)2.47850079
57Mediastinal lymphadenopathy (HP:0100721)2.46722225
58Optic neuritis (HP:0100653)2.46487477
59Retrobulbar optic neuritis (HP:0100654)2.46487477
60Progressive cerebellar ataxia (HP:0002073)2.45609934
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.44922884
62Chest pain (HP:0100749)2.44495945
63Hematochezia (HP:0002573)2.43821505
64Vacuolated lymphocytes (HP:0001922)2.43433669
65Disinhibition (HP:0000734)2.42662344
66Iris hypopigmentation (HP:0007730)2.42507960
67Febrile seizures (HP:0002373)2.41201112
68Recurrent gram-negative bacterial infections (HP:0005420)2.39192754
69Recurrent skin infections (HP:0001581)2.36457919
70Epistaxis (HP:0000421)2.36082528
71Agammaglobulinemia (HP:0004432)2.31846016
72Inappropriate behavior (HP:0000719)2.31336345
73Insidious onset (HP:0003587)2.30721692
74Termporal pattern (HP:0011008)2.30721692
75Abnormal delayed hypersensitivity skin test (HP:0002963)2.30087721
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.29372534
77Recurrent fungal infections (HP:0002841)2.28976365
78Genetic anticipation (HP:0003743)2.28159053
79Vasculitis (HP:0002633)2.27091254
80Metabolic alkalosis (HP:0200114)2.26041023
81Abnormal platelet volume (HP:0011876)2.23310327
82Acute hepatic failure (HP:0006554)2.23191585
83Hyperventilation (HP:0002883)2.22879806
84Hypochromic microcytic anemia (HP:0004840)2.22170000
85Agitation (HP:0000713)2.21173006
86Encephalitis (HP:0002383)2.20366904
87Orchitis (HP:0100796)2.20078109
88Absent speech (HP:0001344)2.19061356
89Anxiety (HP:0000739)2.18894760
90Recurrent bronchitis (HP:0002837)2.18523891
91Blue irides (HP:0000635)2.18328927
92Hypomagnesemia (HP:0002917)2.16116222
93Postural instability (HP:0002172)2.16059878
94Abnormality of the corticospinal tract (HP:0002492)2.15270681
95Abnormality of calcium-phosphate metabolism (HP:0100530)2.14491584
96Meningitis (HP:0001287)2.14483914
97Albinism (HP:0001022)2.13495395
98Megalencephaly (HP:0001355)2.13340690
99Depression (HP:0000716)2.12984293
100T lymphocytopenia (HP:0005403)2.12481206
101Abnormality of T cell number (HP:0011839)2.12071114
102Pulmonary embolism (HP:0002204)2.11884438
103Increased mean platelet volume (HP:0011877)2.11741671
104Abnormality of macrophages (HP:0004311)2.10870115
105Drooling (HP:0002307)2.10570582
106Excessive salivation (HP:0003781)2.10570582
107Myositis (HP:0100614)2.10426382
108Hypokalemic alkalosis (HP:0001949)2.10074465
109Gait imbalance (HP:0002141)2.07197847
110Dementia (HP:0000726)2.07192771
111Truncal ataxia (HP:0002078)2.06673084
112Generalized hypopigmentation of hair (HP:0011358)2.06365651
113Neoplasm of the peripheral nervous system (HP:0100007)2.06080625
114Recurrent sinusitis (HP:0011108)2.04706999
115Failure to thrive in infancy (HP:0001531)2.04464725
116Cerebral hemorrhage (HP:0001342)2.04072414
117Recurrent abscess formation (HP:0002722)2.03176038
118Axonal loss (HP:0003447)2.00606827
119Rapidly progressive (HP:0003678)1.98599558
120Acanthocytosis (HP:0001927)1.97976975
121Hemoptysis (HP:0002105)1.95725064
122Clumsiness (HP:0002312)1.93715507
123Gingivitis (HP:0000230)1.93157476
124Psychosis (HP:0000709)1.92902654
125Spastic gait (HP:0002064)1.92281183
126Abnormality of magnesium homeostasis (HP:0004921)1.91104713
127Stomatitis (HP:0010280)1.90204277
128Segmental peripheral demyelination/remyelination (HP:0003481)1.89808686
129Hyperactive renin-angiotensin system (HP:0000841)1.89739248
130Hemiparesis (HP:0001269)1.89645572
131Hemiplegia (HP:0002301)1.89046376
132Aplasia/Hypoplasia of the macula (HP:0008059)1.88398157
133Amblyopia (HP:0000646)1.87887196
134Keratoconjunctivitis sicca (HP:0001097)1.87807475
135Retinal dysplasia (HP:0007973)1.87708404
136Urinary bladder sphincter dysfunction (HP:0002839)1.87456004
137Progressive neurologic deterioration (HP:0002344)1.86984513
138Arterial thrombosis (HP:0004420)1.86799378
139Viral hepatitis (HP:0006562)1.86636733
140Abnormality of the peritoneum (HP:0002585)1.86383624
141Dysmetria (HP:0001310)1.85852128
142Hip dysplasia (HP:0001385)1.85357574
143Abnormality of renin-angiotensin system (HP:0000847)1.84904508
144Absent/shortened dynein arms (HP:0200106)1.83943677
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.83943677
146Lower limb muscle weakness (HP:0007340)1.82797656
147Hypothermia (HP:0002045)1.82779614
148Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.82497820
149Recurrent bacterial skin infections (HP:0005406)1.81490949
150Recurrent pneumonia (HP:0006532)1.80528344
151Leukocytosis (HP:0001974)1.80385165
152Loss of speech (HP:0002371)1.80223215
153Hypercortisolism (HP:0001578)1.80164436
154Stomach cancer (HP:0012126)1.79874551
155Dyskinesia (HP:0100660)1.79063035
156Abnormality of salivation (HP:0100755)1.77798537
157Scanning speech (HP:0002168)1.76712581
158Degeneration of the lateral corticospinal tracts (HP:0002314)1.76048138
159Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76048138
160Generalized myoclonic seizures (HP:0002123)1.75858382
161Broad-based gait (HP:0002136)1.75841664
162Diminished movement (HP:0002374)1.75755568
163Keratoconjunctivitis (HP:0001096)1.75500237
164Thyroid carcinoma (HP:0002890)1.75462382
165Epileptiform EEG discharges (HP:0011182)1.75449276
166Inability to walk (HP:0002540)1.72449134
167Eczematoid dermatitis (HP:0000976)1.72398254
168EEG with generalized epileptiform discharges (HP:0011198)1.70937781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.12738002
2MAP3K93.18216237
3TIE13.04206513
4CASK2.80448774
5NTRK32.63886333
6RIPK42.57929574
7MINK12.38358720
8MAP3K122.31074369
9MAP3K42.25821268
10TEC2.09542426
11MAP2K72.08687083
12KSR22.08581714
13NTRK11.98196893
14ACVR1B1.89959938
15ARAF1.88062139
16MAP3K21.83928198
17OXSR11.83799527
18LIMK11.74340162
19STK38L1.73511756
20STK241.70077995
21MAP3K61.67277144
22TAOK31.66642548
23GRK51.59997985
24CAMKK21.53402685
25PAK61.50688544
26PLK21.44377047
27DAPK21.38770616
28CDK51.36042048
29ERBB31.32902219
30WNK41.30941865
31SCYL21.30881899
32PHKG21.28085882
33PHKG11.28085882
34WNK31.26178599
35MAPK131.25982491
36NTRK21.24500102
37STK391.24396617
38KSR11.23685097
39BCR1.23511043
40MAP4K21.22484192
41EPHA41.22226769
42DYRK21.17847997
43FES1.17716553
44CSK1.17154081
45MAP3K131.16260481
46PIK3CG1.15574414
47TRIM281.15471018
48TYK21.14007273
49YES11.13675880
50CAMKK11.13533342
51MAP2K41.12765969
52EPHA31.09451482
53PAK31.08682861
54BTK1.07516930
55KIT1.07306395
56JAK31.06682296
57RET1.06653392
58SGK2231.04733809
59SGK4941.04733809
60CSF1R1.03098060
61CSNK1G21.01018713
62BMPR1B1.00216778
63PRKCE0.99904720
64LYN0.99431905
65JAK20.99334858
66HCK0.98378338
67MAP3K50.98290244
68PKN10.98027538
69FGR0.97929543
70SGK30.95143482
71BLK0.93147166
72NME10.86522097
73UHMK10.86491419
74CDK140.86034423
75JAK10.85765036
76TESK10.80877749
77CAMK2A0.80823841
78CAMK2B0.80687387
79BMPR20.80536448
80FRK0.79834244
81PRKCG0.79692751
82GRK70.79525089
83CSNK1G30.78459002
84TNIK0.78166994
85LMTK20.77717048
86EPHB10.76330026
87FER0.75664254
88MAP3K10.74970115
89PINK10.73451907
90CDK180.73212924
91GRK60.71688479
92CCNB10.70930912
93SIK20.70551795
94MST1R0.70037511
95CDK150.68838488
96DYRK1A0.67924892
97TGFBR20.67013716
98IRAK40.66571472
99PTK2B0.65202814
100DYRK1B0.64451231
101FYN0.63996445
102MAP4K10.63926509
103TBK10.63837260
104MAP2K10.63673645
105MARK20.63295923
106CDK190.61853945
107ROCK20.60500679
108LCK0.60399430
109DAPK10.59324875
110CAMK2D0.57998275
111SIK30.55794962
112MST40.54942672
113CSNK1A1L0.54785038
114MAP3K70.53984679
115STK30.53821978
116EGFR0.53819884
117CDK11A0.53334047
118ITK0.53296638
119IRAK10.53128875
120CAMK40.53049183
121PRKCZ0.53002950
122RPS6KA20.52084057
123PDPK10.52017482
124MAP3K140.50991967
125PRKD30.48748058
126SYK0.47439256
127PDK10.46681195
128IKBKE0.46461923
129ERBB20.46176804
130DYRK30.44879136
131PRPF4B0.44709016
132FGFR30.44603625
133CSNK1G10.44162522
134MATK0.42645335
135SGK10.42305479
136MAPKAPK50.42266866
137PRKCH0.42146186
138RAF10.41549937
139INSRR0.38070970
140SGK20.37931304
141PRKCD0.37741825
142MARK30.36527892

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.09948314
2Collecting duct acid secretion_Homo sapiens_hsa049662.72281983
3Staphylococcus aureus infection_Homo sapiens_hsa051502.27734281
4Nicotine addiction_Homo sapiens_hsa050332.23269275
5Vibrio cholerae infection_Homo sapiens_hsa051102.15628011
6Asthma_Homo sapiens_hsa053102.09349032
7GABAergic synapse_Homo sapiens_hsa047271.98437501
8Allograft rejection_Homo sapiens_hsa053301.96176472
9Graft-versus-host disease_Homo sapiens_hsa053321.93849110
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93456905
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90207719
12Autoimmune thyroid disease_Homo sapiens_hsa053201.81211356
13Morphine addiction_Homo sapiens_hsa050321.79287247
14Circadian entrainment_Homo sapiens_hsa047131.71597955
15Olfactory transduction_Homo sapiens_hsa047401.71380807
16Lysosome_Homo sapiens_hsa041421.69866074
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68742828
18Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.63401667
19Dopaminergic synapse_Homo sapiens_hsa047281.61082447
20Glutamatergic synapse_Homo sapiens_hsa047241.59822333
21Serotonergic synapse_Homo sapiens_hsa047261.56728643
22* Phagosome_Homo sapiens_hsa041451.52237065
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.51966996
24Long-term potentiation_Homo sapiens_hsa047201.51176035
25Cholinergic synapse_Homo sapiens_hsa047251.46974878
26Rheumatoid arthritis_Homo sapiens_hsa053231.44717661
27Insulin secretion_Homo sapiens_hsa049111.42155899
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40633084
29Salivary secretion_Homo sapiens_hsa049701.37634244
30Gastric acid secretion_Homo sapiens_hsa049711.35217325
31Amphetamine addiction_Homo sapiens_hsa050311.33899354
32Renin secretion_Homo sapiens_hsa049241.32675226
33Platelet activation_Homo sapiens_hsa046111.31458930
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27818860
35Long-term depression_Homo sapiens_hsa047301.27745679
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25651867
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22570377
38Cocaine addiction_Homo sapiens_hsa050301.20309384
39Toxoplasmosis_Homo sapiens_hsa051451.17911081
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15875383
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13626106
42* SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13448088
43Viral myocarditis_Homo sapiens_hsa054161.11925562
44Hematopoietic cell lineage_Homo sapiens_hsa046401.11723544
45Taste transduction_Homo sapiens_hsa047421.11282286
46Oxidative phosphorylation_Homo sapiens_hsa001901.10721550
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07180663
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.05581499
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05473936
50Axon guidance_Homo sapiens_hsa043601.03851112
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01262856
52Oxytocin signaling pathway_Homo sapiens_hsa049210.98852934
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96882201
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95284737
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95046002
56Gap junction_Homo sapiens_hsa045400.94820852
57Tuberculosis_Homo sapiens_hsa051520.94621728
58Alzheimers disease_Homo sapiens_hsa050100.93957205
59Type II diabetes mellitus_Homo sapiens_hsa049300.93626388
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.92222705
61Endocytosis_Homo sapiens_hsa041440.91484205
62Pertussis_Homo sapiens_hsa051330.89700741
63GnRH signaling pathway_Homo sapiens_hsa049120.87529008
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87074920
65Renal cell carcinoma_Homo sapiens_hsa052110.84844717
66Glioma_Homo sapiens_hsa052140.84802825
67Salmonella infection_Homo sapiens_hsa051320.84503996
68Estrogen signaling pathway_Homo sapiens_hsa049150.80854183
69Antigen processing and presentation_Homo sapiens_hsa046120.79716975
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.79426308
71Influenza A_Homo sapiens_hsa051640.78506908
72cAMP signaling pathway_Homo sapiens_hsa040240.77808321
73Type I diabetes mellitus_Homo sapiens_hsa049400.77629771
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77422489
75Calcium signaling pathway_Homo sapiens_hsa040200.76447323
76Other glycan degradation_Homo sapiens_hsa005110.76117927
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74861897
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73833474
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73663958
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73554411
81Chemokine signaling pathway_Homo sapiens_hsa040620.73011475
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.71889752
83Osteoclast differentiation_Homo sapiens_hsa043800.71322537
84Sphingolipid metabolism_Homo sapiens_hsa006000.71270271
85ErbB signaling pathway_Homo sapiens_hsa040120.70893028
86Cardiac muscle contraction_Homo sapiens_hsa042600.70202030
87Malaria_Homo sapiens_hsa051440.69595488
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68791450
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68724053
90Parkinsons disease_Homo sapiens_hsa050120.68460465
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68354749
92Fatty acid biosynthesis_Homo sapiens_hsa000610.68268724
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67977645
94Rap1 signaling pathway_Homo sapiens_hsa040150.67177921
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65084577
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64642262
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64451272
98Thyroid hormone synthesis_Homo sapiens_hsa049180.63948117
99Leishmaniasis_Homo sapiens_hsa051400.62924603
100Prion diseases_Homo sapiens_hsa050200.62524766
101Inositol phosphate metabolism_Homo sapiens_hsa005620.62303718
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61774332
103B cell receptor signaling pathway_Homo sapiens_hsa046620.60918325
104Ras signaling pathway_Homo sapiens_hsa040140.60181634
105VEGF signaling pathway_Homo sapiens_hsa043700.60116274
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.59927941
107Prolactin signaling pathway_Homo sapiens_hsa049170.59838036
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.59227385
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59079354
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58116097
111T cell receptor signaling pathway_Homo sapiens_hsa046600.57494415
112Pancreatic secretion_Homo sapiens_hsa049720.57184652
113MAPK signaling pathway_Homo sapiens_hsa040100.56123041
114Phototransduction_Homo sapiens_hsa047440.55989166
115Dorso-ventral axis formation_Homo sapiens_hsa043200.55927880
116Mineral absorption_Homo sapiens_hsa049780.55066185
117TNF signaling pathway_Homo sapiens_hsa046680.54964168
118FoxO signaling pathway_Homo sapiens_hsa040680.54765152
119Melanogenesis_Homo sapiens_hsa049160.53836901
120Shigellosis_Homo sapiens_hsa051310.53499290
121Butanoate metabolism_Homo sapiens_hsa006500.52769300
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.52411108
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52083686
124Ether lipid metabolism_Homo sapiens_hsa005650.51966068
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50027549
126Primary immunodeficiency_Homo sapiens_hsa053400.48779748
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48432312
128Choline metabolism in cancer_Homo sapiens_hsa052310.47063825
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46071132
130Regulation of autophagy_Homo sapiens_hsa041400.45852173
131Pancreatic cancer_Homo sapiens_hsa052120.45522620
132African trypanosomiasis_Homo sapiens_hsa051430.45319215
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45135622

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