STX8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.80071938
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.66883904
3cullin deneddylation (GO:0010388)4.58147063
4protein deneddylation (GO:0000338)4.24288899
5platelet dense granule organization (GO:0060155)4.16436969
6superoxide anion generation (GO:0042554)4.03953645
7tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.93840485
8RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.93840485
9neutrophil activation involved in immune response (GO:0002283)3.89483343
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.87039868
11ATP synthesis coupled proton transport (GO:0015986)3.80011913
12energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80011913
13DNA deamination (GO:0045006)3.70497830
14respiratory electron transport chain (GO:0022904)3.64938235
15viral transcription (GO:0019083)3.60375851
16ATP biosynthetic process (GO:0006754)3.59989556
17water-soluble vitamin biosynthetic process (GO:0042364)3.59056509
18electron transport chain (GO:0022900)3.56295479
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53595797
20translational termination (GO:0006415)3.52733303
21cotranslational protein targeting to membrane (GO:0006613)3.51620101
22protein complex biogenesis (GO:0070271)3.51574968
23protein targeting to ER (GO:0045047)3.49514433
24ribosomal small subunit assembly (GO:0000028)3.46233419
25purine nucleoside triphosphate biosynthetic process (GO:0009145)3.45727872
26purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.38430483
27protein neddylation (GO:0045116)3.37049200
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34600274
29protein localization to endoplasmic reticulum (GO:0070972)3.33124592
30sequestering of actin monomers (GO:0042989)3.31333788
31ubiquinone biosynthetic process (GO:0006744)3.27400079
32regulation of activation of Janus kinase activity (GO:0010533)3.23382255
33behavioral response to nicotine (GO:0035095)3.23265042
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19389132
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.19389132
36NADH dehydrogenase complex assembly (GO:0010257)3.19389132
37signal peptide processing (GO:0006465)3.17363663
38purine nucleotide salvage (GO:0032261)3.14450742
39adenosine metabolic process (GO:0046085)3.09438224
40GTP biosynthetic process (GO:0006183)3.06679707
41regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.05018113
42translational elongation (GO:0006414)3.04304434
43response to peptidoglycan (GO:0032494)3.04101355
44inner mitochondrial membrane organization (GO:0007007)3.01052677
45long-chain fatty acid biosynthetic process (GO:0042759)3.00282033
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00028836
47negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.98955511
48mitochondrial respiratory chain complex assembly (GO:0033108)2.98697970
49cytochrome complex assembly (GO:0017004)2.97045569
50positive regulation of monocyte chemotaxis (GO:0090026)2.96931847
51protein-cofactor linkage (GO:0018065)2.96331150
52respiratory burst (GO:0045730)2.95662715
53ubiquinone metabolic process (GO:0006743)2.94824206
54positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.94004560
55natural killer cell activation involved in immune response (GO:0002323)2.92552805
56phagosome maturation (GO:0090382)2.90948671
57T-helper 1 type immune response (GO:0042088)2.90918205
58proteasome assembly (GO:0043248)2.90081630
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89873038
60regulation of mitochondrial translation (GO:0070129)2.88122743
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87275688
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84752198
63translation (GO:0006412)2.83724357
64negative regulation of myeloid cell apoptotic process (GO:0033033)2.83659937
65positive regulation of interleukin-17 production (GO:0032740)2.81679465
66ribonucleoside triphosphate biosynthetic process (GO:0009201)2.81332864
67mannosylation (GO:0097502)2.81320820
68aldehyde catabolic process (GO:0046185)2.80158052
69negative regulation of telomere maintenance (GO:0032205)2.79669176
70neutrophil activation (GO:0042119)2.76810799
71intracellular protein transmembrane import (GO:0044743)2.76493287
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76463422
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76463422
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76463422
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75687736
76protein localization to cilium (GO:0061512)2.75609270
77lipoxygenase pathway (GO:0019372)2.75551638
78eosinophil chemotaxis (GO:0048245)2.75339327
79protein targeting to mitochondrion (GO:0006626)2.75249122
80DNA double-strand break processing (GO:0000729)2.74775365
81GPI anchor biosynthetic process (GO:0006506)2.74719635
82maturation of SSU-rRNA (GO:0030490)2.74564764
83establishment of protein localization to mitochondrion (GO:0072655)2.74475769
84viral life cycle (GO:0019058)2.74184537
85purine-containing compound salvage (GO:0043101)2.73912878
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72438377
87signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72438377
88purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.72402252
89ribosomal small subunit biogenesis (GO:0042274)2.72056426
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.71957324
91keratinocyte development (GO:0003334)2.70566366
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.70086060
93termination of RNA polymerase III transcription (GO:0006386)2.70086060
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.69524697
95cellular response to interferon-beta (GO:0035458)2.65912602
96cellular protein complex disassembly (GO:0043624)2.65594671
97regulation of cellular respiration (GO:0043457)2.65566403
98amino sugar catabolic process (GO:0046348)2.65224320
99cellular component biogenesis (GO:0044085)2.65013551
100granulocyte activation (GO:0036230)2.64168779
101iron-sulfur cluster assembly (GO:0016226)2.63600010
102metallo-sulfur cluster assembly (GO:0031163)2.63600010
103respiratory chain complex IV assembly (GO:0008535)2.63146363
104protein localization to mitochondrion (GO:0070585)2.61895983
105anterograde synaptic vesicle transport (GO:0048490)2.61029199
106deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.60302054
107nucleoside triphosphate biosynthetic process (GO:0009142)2.59880046
108microglial cell activation (GO:0001774)2.59608495
109signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58262216
110signal transduction involved in DNA damage checkpoint (GO:0072422)2.58262216
111peptidyl-histidine modification (GO:0018202)2.57852047
112signal transduction involved in cell cycle checkpoint (GO:0072395)2.57083697
113chaperone-mediated protein transport (GO:0072321)2.56480671
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56005626
115pseudouridine synthesis (GO:0001522)2.55626617
116negative regulation of ligase activity (GO:0051352)2.55422855
117negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55422855
118oxidative phosphorylation (GO:0006119)2.55307652
119cellular ketone body metabolic process (GO:0046950)2.52992897
120quinone biosynthetic process (GO:1901663)2.52578582
121mitochondrial transport (GO:0006839)2.52482471
122positive regulation of mast cell activation involved in immune response (GO:0033008)2.52077282
123positive regulation of mast cell degranulation (GO:0043306)2.52077282
124autophagic vacuole fusion (GO:0000046)2.51566414
125nucleotide transmembrane transport (GO:1901679)2.51553736
126positive regulation of T cell migration (GO:2000406)2.51121280
127nonmotile primary cilium assembly (GO:0035058)2.51083622
128regulation of cilium movement (GO:0003352)2.50231655
129hydrogen ion transmembrane transport (GO:1902600)2.50029382
130positive regulation by symbiont of host defense response (GO:0052509)2.49509964
131modulation by symbiont of host defense response (GO:0052031)2.49509964
132modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49509964
133modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49509964
134positive regulation by organism of defense response of other organism involved in symbiotic interact2.49509964
135modulation by symbiont of host immune response (GO:0052553)2.49509964
136monocyte chemotaxis (GO:0002548)2.49043909
137eosinophil migration (GO:0072677)2.45694841
138nucleoside diphosphate phosphorylation (GO:0006165)2.45084180
139superoxide metabolic process (GO:0006801)2.44035924
140positive regulation of interleukin-1 beta secretion (GO:0050718)2.42734806
141deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.42063648
142response to redox state (GO:0051775)2.40891175
143proton transport (GO:0015992)2.40255953
144regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.39506941
145regulation of interleukin-17 production (GO:0032660)2.39467439
146positive regulation of lymphocyte migration (GO:2000403)2.39177044
147positive regulation of cellular amide metabolic process (GO:0034250)2.38398580
148positive regulation of cell fate commitment (GO:0010455)2.38222627
149regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.37634686
150positive regulation of defense response to virus by host (GO:0002230)2.37466690
151hydrogen peroxide biosynthetic process (GO:0050665)2.37082488
152regulation of cellular amino acid metabolic process (GO:0006521)2.37000634
153GPI anchor metabolic process (GO:0006505)2.35653242
154regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.35559350
155regulation of RIG-I signaling pathway (GO:0039535)2.35545776
156regulation of T cell migration (GO:2000404)2.35173504
157glucosamine-containing compound catabolic process (GO:1901072)2.34554109
158positive regulation of antigen processing and presentation (GO:0002579)2.33175390
159hydrogen transport (GO:0006818)2.32620025
160regulation of antigen processing and presentation (GO:0002577)2.32136668
161regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.32094915
162ceramide catabolic process (GO:0046514)2.31077229
163protein heterotetramerization (GO:0051290)2.31054218
164positive regulation of interleukin-1 secretion (GO:0050716)2.30664298
165detection of other organism (GO:0098543)2.30660495
166regulation of chronic inflammatory response (GO:0002676)2.30529566
167preassembly of GPI anchor in ER membrane (GO:0016254)2.30044895
168positive regulation of interleukin-10 production (GO:0032733)2.29503468
169regulation of dendritic cell antigen processing and presentation (GO:0002604)2.28209513
170regulation of mast cell activation (GO:0033003)2.27124503
171regulation of immunoglobulin secretion (GO:0051023)2.26975121
172regulation of inflammatory response to antigenic stimulus (GO:0002861)2.25375038
173leukocyte degranulation (GO:0043299)2.25149104
174positive regulation of mast cell activation (GO:0033005)2.25073164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.56033877
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.86012079
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.70683906
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.36013908
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.20462089
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.94998570
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.94499183
8ZNF274_21170338_ChIP-Seq_K562_Hela2.88761100
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82810148
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59609128
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54406684
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.51084564
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42415798
14VDR_23849224_ChIP-Seq_CD4+_Human2.34983160
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21498098
16GBX2_23144817_ChIP-Seq_PC3_Human2.21074694
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15431573
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.15272092
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13315934
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.08321093
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04026823
22VDR_22108803_ChIP-Seq_LS180_Human2.02891526
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01816621
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00447172
25FOXP3_21729870_ChIP-Seq_TREG_Human1.84305888
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78978818
27EWS_26573619_Chip-Seq_HEK293_Human1.77027285
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76485185
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76461029
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73686551
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.69267785
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.59971802
33EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59710699
34MYC_18940864_ChIP-ChIP_HL60_Human1.58355971
35STAT3_18555785_Chip-Seq_ESCs_Mouse1.58339194
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58150073
37TP53_22573176_ChIP-Seq_HFKS_Human1.58007694
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57895958
39* SRF_21415370_ChIP-Seq_HL-1_Mouse1.57797680
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55253341
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54987627
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54689883
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53049341
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.52328456
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51254924
46P53_22387025_ChIP-Seq_ESCs_Mouse1.49420932
47* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49170930
48ELK1_19687146_ChIP-ChIP_HELA_Human1.46871232
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44788255
50NMYC_18555785_Chip-Seq_ESCs_Mouse1.44780557
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.44736066
52P300_19829295_ChIP-Seq_ESCs_Human1.44337123
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44261043
54EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43530216
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40381759
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.40332213
57RUNX1_27457419_Chip-Seq_LIVER_Mouse1.40190625
58TAF15_26573619_Chip-Seq_HEK293_Human1.39663338
59P300_18555785_Chip-Seq_ESCs_Mouse1.38322014
60ER_23166858_ChIP-Seq_MCF-7_Human1.38063499
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.37678454
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.37556187
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37505303
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37377887
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35352683
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.35352683
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32276158
68SOX2_18555785_Chip-Seq_ESCs_Mouse1.32104299
69HTT_18923047_ChIP-ChIP_STHdh_Human1.31556995
70IRF1_19129219_ChIP-ChIP_H3396_Human1.30784166
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.30250394
72PU1_27457419_Chip-Seq_LIVER_Mouse1.25695826
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25010375
74AR_20517297_ChIP-Seq_VCAP_Human1.24861673
75EZH2_22144423_ChIP-Seq_EOC_Human1.24757582
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24663253
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.24353029
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.23311518
79ZFX_18555785_Chip-Seq_ESCs_Mouse1.22971021
80SMAD1_18555785_Chip-Seq_ESCs_Mouse1.22779190
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22573586
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.22368032
83NANOG_19829295_ChIP-Seq_ESCs_Human1.22341072
84SOX2_19829295_ChIP-Seq_ESCs_Human1.22341072
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22140837
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21927717
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19808228
88CBP_20019798_ChIP-Seq_JUKART_Human1.18813510
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18813510
90NCOR_22424771_ChIP-Seq_293T_Human1.18097673
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.15220092
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.14763063
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14732229
94RNF2_27304074_Chip-Seq_NSC_Mouse1.13719453
95ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12924375
96ERG_20517297_ChIP-Seq_VCAP_Human1.12842565
97KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08637261
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07864400
99FUS_26573619_Chip-Seq_HEK293_Human1.07842240
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07037315
101GABP_19822575_ChIP-Seq_HepG2_Human1.06815085
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06794140
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06570081
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06476478
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06168692
106ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05722002
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.05347787
108GATA3_21878914_ChIP-Seq_MCF-7_Human1.05293654
109BCAT_22108803_ChIP-Seq_LS180_Human1.05160003
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04864208
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03098636
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02970868
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02815279
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01718272
115IGF1R_20145208_ChIP-Seq_DFB_Human1.01536247
116MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99615774
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99521016
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99485864
119DCP1A_22483619_ChIP-Seq_HELA_Human0.99264622
120EED_16625203_ChIP-ChIP_MESCs_Mouse0.99169671
121MYC_18555785_ChIP-Seq_MESCs_Mouse0.98859178
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98853445
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98633920
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.98286599
125STAT1_20625510_ChIP-Seq_HELA_Human0.97794931
126FOXH1_21741376_ChIP-Seq_EPCs_Human0.97788312
127* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97352633
128THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96961831
129* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96598988
130CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96469427
131* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96280075
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96106297
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95231280
134NOTCH1_21737748_ChIP-Seq_TLL_Human0.94886778
135TP53_18474530_ChIP-ChIP_U2OS_Human0.94048375
136E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94024883
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93151292
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92663164
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92625754
140* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92562347
141PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91939442
142POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91887271
143* TTF2_22483619_ChIP-Seq_HELA_Human0.91432893
144AR_25329375_ChIP-Seq_VCAP_Human0.90831935
145PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90142975
146TCF4_22108803_ChIP-Seq_LS180_Human0.89975015
147STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88662292
148CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88303908
149* KDM2B_26808549_Chip-Seq_REH_Human0.87428473
150NANOG_20526341_ChIP-Seq_ESCs_Human0.87292498
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86920816
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86697187
153MYC_19829295_ChIP-Seq_ESCs_Human0.86502843
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85329421
155TAF2_19829295_ChIP-Seq_ESCs_Human0.85013515
156* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84748156
157SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84661599
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82176643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.90437683
2MP0003136_yellow_coat_color3.88599198
3MP0002148_abnormal_hypersensitivity_rea3.03915814
4MP0002277_abnormal_respiratory_mucosa2.86845091
5MP0009785_altered_susceptibility_to2.70812183
6MP0001835_abnormal_antigen_presentation2.64061233
7MP0000372_irregular_coat_pigmentation2.55302436
8MP0006072_abnormal_retinal_apoptosis2.48510555
9MP0002132_abnormal_respiratory_system2.45250535
10MP0002653_abnormal_ependyma_morphology2.44280861
11MP0009379_abnormal_foot_pigmentation2.38644267
12MP0002163_abnormal_gland_morphology2.38341159
13MP0001986_abnormal_taste_sensitivity2.38183599
14MP0003806_abnormal_nucleotide_metabolis2.31179433
15MP0005171_absent_coat_pigmentation2.29139751
16MP0003724_increased_susceptibility_to2.24448106
17MP0004381_abnormal_hair_follicle2.19793608
18MP0003011_delayed_dark_adaptation2.14416743
19MP0005671_abnormal_response_to2.12627485
20MP0008877_abnormal_DNA_methylation2.08233080
21MP0006082_CNS_inflammation2.06695238
22MP0002638_abnormal_pupillary_reflex2.06281129
23MP0005379_endocrine/exocrine_gland_phen2.05639027
24MP0006292_abnormal_olfactory_placode2.05342317
25MP0000015_abnormal_ear_pigmentation2.02148365
26MP0006036_abnormal_mitochondrial_physio2.01884446
27MP0005551_abnormal_eye_electrophysiolog1.99370933
28MP0010386_abnormal_urinary_bladder1.96559533
29MP0005000_abnormal_immune_tolerance1.96367751
30MP0002419_abnormal_innate_immunity1.93457252
31MP0005025_abnormal_response_to1.91771877
32MP0005387_immune_system_phenotype1.90228528
33MP0001790_abnormal_immune_system1.90228528
34MP0008260_abnormal_autophagy1.88988009
35MP0009697_abnormal_copulation1.83989650
36MP0001188_hyperpigmentation1.83136222
37MP0001905_abnormal_dopamine_level1.81339442
38MP0003436_decreased_susceptibility_to1.76929729
39MP0006054_spinal_hemorrhage1.73370737
40MP0008875_abnormal_xenobiotic_pharmacok1.72209476
41MP0003186_abnormal_redox_activity1.72062868
42MP0005253_abnormal_eye_physiology1.71110771
43MP0004145_abnormal_muscle_electrophysio1.67065465
44MP0002138_abnormal_hepatobiliary_system1.64771265
45MP0009046_muscle_twitch1.64111157
46MP0000566_synostosis1.64027238
47MP0002876_abnormal_thyroid_physiology1.61323504
48MP0003787_abnormal_imprinting1.57684120
49MP0001764_abnormal_homeostasis1.57207084
50MP0008872_abnormal_physiological_respon1.52391359
51MP0003646_muscle_fatigue1.52106572
52MP0001984_abnormal_olfaction1.50374529
53MP0005409_darkened_coat_color1.46107635
54MP0002723_abnormal_immune_serum1.45904979
55MP0001529_abnormal_vocalization1.44701817
56MP0003880_abnormal_central_pattern1.44464960
57MP0002452_abnormal_antigen_presenting1.41494600
58MP0006276_abnormal_autonomic_nervous1.40372352
59MP0009764_decreased_sensitivity_to1.39600601
60MP0001346_abnormal_lacrimal_gland1.39270645
61MP0005410_abnormal_fertilization1.36998550
62MP0002102_abnormal_ear_morphology1.35009454
63MP0002272_abnormal_nervous_system1.31262098
64MP0005408_hypopigmentation1.30929778
65MP0005174_abnormal_tail_pigmentation1.28553466
66MP0004782_abnormal_surfactant_physiolog1.28114025
67MP0009745_abnormal_behavioral_response1.26820133
68MP0004215_abnormal_myocardial_fiber1.26089824
69MP0004742_abnormal_vestibular_system1.25853624
70MP0001800_abnormal_humoral_immune1.25451349
71MP0005451_abnormal_body_composition1.25415256
72MP0005389_reproductive_system_phenotype1.24929476
73MP0002735_abnormal_chemical_nociception1.23843911
74MP0001819_abnormal_immune_cell1.22478359
75MP0008058_abnormal_DNA_repair1.22130034
76MP0002420_abnormal_adaptive_immunity1.20244707
77MP0005310_abnormal_salivary_gland1.19422760
78MP0008789_abnormal_olfactory_epithelium1.18554876
79MP0002736_abnormal_nociception_after1.18511008
80MP0005058_abnormal_lysosome_morphology1.16991704
81MP0000613_abnormal_salivary_gland1.15342472
82MP0004043_abnormal_pH_regulation1.14457106
83MP0001968_abnormal_touch/_nociception1.11938719
84MP0000631_abnormal_neuroendocrine_gland1.11358798
85MP0000920_abnormal_myelination1.08840961
86MP0000685_abnormal_immune_system1.08220903
87MP0005332_abnormal_amino_acid1.08148658
88MP0002095_abnormal_skin_pigmentation1.07959721
89MP0003183_abnormal_peptide_metabolism1.04529921
90MP0001542_abnormal_bone_strength1.02602319
91MP0002405_respiratory_system_inflammati1.02112110
92MP0005084_abnormal_gallbladder_morpholo1.01097712
93MP0001919_abnormal_reproductive_system0.99484792
94MP0002234_abnormal_pharynx_morphology0.99028299
95MP0002938_white_spotting0.98775422
96MP0006035_abnormal_mitochondrial_morpho0.97981623
97MP0001486_abnormal_startle_reflex0.96912590
98MP0000569_abnormal_digit_pigmentation0.96482922
99MP0005646_abnormal_pituitary_gland0.96332339
100MP0003786_premature_aging0.95206504
101MP0003941_abnormal_skin_development0.94808407
102MP0002160_abnormal_reproductive_system0.92594942
103MP0001845_abnormal_inflammatory_respons0.91934546
104MP0005257_abnormal_intraocular_pressure0.91652333
105MP0002733_abnormal_thermal_nociception0.90749978
106MP0009333_abnormal_splenocyte_physiolog0.90681626
107MP0004147_increased_porphyrin_level0.90384212
108MP0003252_abnormal_bile_duct0.90141286
109MP0005266_abnormal_metabolism0.89960196
110MP0003718_maternal_effect0.88387035
111MP0001853_heart_inflammation0.87110785
112MP0008469_abnormal_protein_level0.86710229
113MP0001533_abnormal_skeleton_physiology0.85233425
114MP0002295_abnormal_pulmonary_circulatio0.84598852
115MP0002064_seizures0.83990504
116MP0002933_joint_inflammation0.83881234
117MP0000026_abnormal_inner_ear0.82667071
118MP0002090_abnormal_vision0.82417923
119MP0005075_abnormal_melanosome_morpholog0.81006899
120MP0005195_abnormal_posterior_eye0.80104674
121MP0001756_abnormal_urination0.79385609
122MP0002998_abnormal_bone_remodeling0.79217230
123MP0003195_calcinosis0.78874659
124MP0002751_abnormal_autonomic_nervous0.78754424
125MP0010155_abnormal_intestine_physiology0.77884492
126MP0002572_abnormal_emotion/affect_behav0.77524121
127MP0001324_abnormal_eye_pigmentation0.77392464
128MP0005636_abnormal_mineral_homeostasis0.77380871
129MP0001970_abnormal_pain_threshold0.76891321
130MP0005499_abnormal_olfactory_system0.76780988
131MP0005394_taste/olfaction_phenotype0.76780988
132MP0000681_abnormal_thyroid_gland0.75981729
133MP0008004_abnormal_stomach_pH0.74581679
134MP0003763_abnormal_thymus_physiology0.74393379
135MP0005645_abnormal_hypothalamus_physiol0.73966499
136MP0002139_abnormal_hepatobiliary_system0.73809095
137MP0001963_abnormal_hearing_physiology0.72328856
138MP0000230_abnormal_systemic_arterial0.71774799
139MP0008775_abnormal_heart_ventricle0.71170412
140MP0003950_abnormal_plasma_membrane0.70532259
141MP0003137_abnormal_impulse_conducting0.70497049
142MP0001663_abnormal_digestive_system0.70440031
143MP0004885_abnormal_endolymph0.70297377
144MP0000716_abnormal_immune_system0.69995749
145MP0003121_genomic_imprinting0.69525368
146MP0002693_abnormal_pancreas_physiology0.69148414
147MP0001873_stomach_inflammation0.68703607
148MP0008995_early_reproductive_senescence0.68442120
149MP0002928_abnormal_bile_duct0.68364501
150MP0002557_abnormal_social/conspecific_i0.67847580
151MP0001502_abnormal_circadian_rhythm0.67215553
152MP0002177_abnormal_outer_ear0.65234913
153MP0001485_abnormal_pinna_reflex0.64860595
154MP0004142_abnormal_muscle_tone0.64813804

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.48167533
2Mitochondrial inheritance (HP:0001427)3.92982419
3Abnormal mitochondria in muscle tissue (HP:0008316)3.75838611
4Increased hepatocellular lipid droplets (HP:0006565)3.71309180
5Progressive macrocephaly (HP:0004481)3.62813569
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.59313954
7Renal Fanconi syndrome (HP:0001994)3.53651502
8Parakeratosis (HP:0001036)3.36713527
93-Methylglutaconic aciduria (HP:0003535)3.31997084
10Acute encephalopathy (HP:0006846)3.28201866
11Pancreatic cysts (HP:0001737)3.22553768
12Recurrent abscess formation (HP:0002722)3.22236593
13Molar tooth sign on MRI (HP:0002419)3.21693421
14Abnormality of midbrain morphology (HP:0002418)3.21693421
15Eczematoid dermatitis (HP:0000976)3.19599623
16Pancreatic fibrosis (HP:0100732)3.12008432
17Lipid accumulation in hepatocytes (HP:0006561)3.07533179
18Increased CSF lactate (HP:0002490)3.06909738
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06456278
20Hypothermia (HP:0002045)3.04570907
21Abnormality of macrophages (HP:0004311)2.99128481
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.98710128
23Exertional dyspnea (HP:0002875)2.98108349
24Vacuolated lymphocytes (HP:0001922)2.92504148
25Abnormality of renal resorption (HP:0011038)2.86682811
26Increased IgM level (HP:0003496)2.83731777
27Medial flaring of the eyebrow (HP:0010747)2.78294508
28Hepatocellular necrosis (HP:0001404)2.76330049
29Recurrent bacterial skin infections (HP:0005406)2.75707171
30Retrobulbar optic neuritis (HP:0100654)2.74575736
31Optic neuritis (HP:0100653)2.74575736
32Abnormality of alanine metabolism (HP:0010916)2.73379487
33Hyperalaninemia (HP:0003348)2.73379487
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73379487
35Congenital stationary night blindness (HP:0007642)2.68699278
36Optic disc pallor (HP:0000543)2.63730971
37Congenital ichthyosiform erythroderma (HP:0007431)2.60298029
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.59046788
39Absent/shortened dynein arms (HP:0200106)2.59046788
40Patchy hypopigmentation of hair (HP:0011365)2.55630083
41Chronic hepatic failure (HP:0100626)2.55095322
42Type I transferrin isoform profile (HP:0003642)2.48384712
43Obstructive lung disease (HP:0006536)2.47161562
44Chronic obstructive pulmonary disease (HP:0006510)2.47161562
45Nephronophthisis (HP:0000090)2.45889114
46Increased muscle lipid content (HP:0009058)2.42877486
47Hepatic necrosis (HP:0002605)2.42834169
48CNS demyelination (HP:0007305)2.41845400
49Abnormal hair whorl (HP:0010721)2.41528724
50Abnormal number of erythroid precursors (HP:0012131)2.40407393
51White forelock (HP:0002211)2.40029454
52Prolonged neonatal jaundice (HP:0006579)2.34673919
53Constricted visual fields (HP:0001133)2.31585001
54Exercise intolerance (HP:0003546)2.30759264
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30304937
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30304937
57Lethargy (HP:0001254)2.28378649
58Generalized aminoaciduria (HP:0002909)2.28132573
59Type 2 muscle fiber atrophy (HP:0003554)2.25669140
60Orchitis (HP:0100796)2.24537248
61Abolished electroretinogram (ERG) (HP:0000550)2.24188181
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22449292
63Nephrogenic diabetes insipidus (HP:0009806)2.20075415
64Abnormal ciliary motility (HP:0012262)2.19554624
65Congenital sensorineural hearing impairment (HP:0008527)2.16499271
66Stomatitis (HP:0010280)2.16478986
67Congenital primary aphakia (HP:0007707)2.16135336
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16010484
69Abnormality of secondary sexual hair (HP:0009888)2.15748785
70Abnormality of the axillary hair (HP:0100134)2.15748785
71Aplasia/Hypoplasia of the fovea (HP:0008060)2.14909559
72Hypoplasia of the fovea (HP:0007750)2.14909559
73Prostate neoplasm (HP:0100787)2.14019384
74Abnormal respiratory motile cilium morphology (HP:0005938)2.12318586
75Abnormal respiratory epithelium morphology (HP:0012253)2.12318586
76Conical tooth (HP:0000698)2.10908291
77Methylmalonic aciduria (HP:0012120)2.09943966
78Increased intramyocellular lipid droplets (HP:0012240)2.09415481
79Recurrent gram-negative bacterial infections (HP:0005420)2.09115229
80Respiratory failure (HP:0002878)2.07917477
81Methylmalonic acidemia (HP:0002912)2.05882253
82Gait imbalance (HP:0002141)2.04606654
83Hyperglycinemia (HP:0002154)2.04511834
84Cerebral edema (HP:0002181)2.03872618
85Renal cortical cysts (HP:0000803)2.03162391
86Leukodystrophy (HP:0002415)2.01382464
87Abnormality of the renal cortex (HP:0011035)2.00223601
88Recurrent pneumonia (HP:0006532)1.99482170
89Sclerocornea (HP:0000647)1.99322360
90Colon cancer (HP:0003003)1.99068744
91Mediastinal lymphadenopathy (HP:0100721)1.98727018
92Respiratory difficulties (HP:0002880)1.95982386
93Abnormal respiratory motile cilium physiology (HP:0012261)1.93281016
94Aplastic anemia (HP:0001915)1.92172488
95Elevated erythrocyte sedimentation rate (HP:0003565)1.92026493
96Abnormality of the renal medulla (HP:0100957)1.91800823
97Myositis (HP:0100614)1.90488893
98Thyroiditis (HP:0100646)1.90485679
99Vasculitis (HP:0002633)1.88991597
100True hermaphroditism (HP:0010459)1.87875884
101Macrocytic anemia (HP:0001972)1.87221333
102Tubulointerstitial nephritis (HP:0001970)1.86338581
103Aplasia/Hypoplasia of the tongue (HP:0010295)1.85292925
104X-linked dominant inheritance (HP:0001423)1.83995473
105Abnormal protein glycosylation (HP:0012346)1.83960601
106Abnormal glycosylation (HP:0012345)1.83960601
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83960601
108Abnormal protein N-linked glycosylation (HP:0012347)1.83960601
109Recurrent skin infections (HP:0001581)1.83645243
110Abnormal drinking behavior (HP:0030082)1.83409377
111Polydipsia (HP:0001959)1.83409377
112Increased serum lactate (HP:0002151)1.82311323
113Renal tubular dysfunction (HP:0000124)1.81975411
114Abnormal rod and cone electroretinograms (HP:0008323)1.81300715
115Abnormality of urine glucose concentration (HP:0011016)1.80903606
116Glycosuria (HP:0003076)1.80903606
117Lactic acidosis (HP:0003128)1.80777988
118Abnormality of serum amino acid levels (HP:0003112)1.80733907
119Cystic liver disease (HP:0006706)1.79833797
120Nasolacrimal duct obstruction (HP:0000579)1.78043219
121Muscle fiber atrophy (HP:0100295)1.77601014
122Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77098379
123Anencephaly (HP:0002323)1.76371941
124Pulmonary artery stenosis (HP:0004415)1.75166115
125Genital tract atresia (HP:0001827)1.74463042
126Basal ganglia calcification (HP:0002135)1.74323811
127Dry hair (HP:0011359)1.73996594
128Type II lissencephaly (HP:0007260)1.73580601
129Aplasia/Hypoplasia of the lens (HP:0008063)1.72717502
130Abnormality of cells of the erythroid lineage (HP:0012130)1.70364913
131Male pseudohermaphroditism (HP:0000037)1.69681759
132Septo-optic dysplasia (HP:0100842)1.69620335
133Xerostomia (HP:0000217)1.67445201
134Hypergammaglobulinemia (HP:0010702)1.66389486
135Vaginal atresia (HP:0000148)1.65077798
136Microvesicular hepatic steatosis (HP:0001414)1.64910977
137Emotional lability (HP:0000712)1.64884196
138Popliteal pterygium (HP:0009756)1.64635896
139Aplasia/hypoplasia of the uterus (HP:0008684)1.64581770
140Congenital, generalized hypertrichosis (HP:0004540)1.64383543
141Dicarboxylic aciduria (HP:0003215)1.64164477
142Abnormality of the renal collecting system (HP:0004742)1.63942272
143Abnormality of the fovea (HP:0000493)1.63916939
144Anhidrosis (HP:0000970)1.63784144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.85713462
2FRK3.17699823
3STK163.10850026
4MAP4K23.02426320
5IRAK32.80980900
6CASK2.77185627
7BMPR1B2.65286885
8PBK2.61160441
9IRAK42.52606973
10MAP3K142.34868422
11BMPR22.26284696
12TXK2.23975627
13PASK2.23052155
14MAP3K122.16670608
15WNK32.16121951
16NME22.15818528
17NME12.09519597
18GRK72.05651336
19ZAK2.04633487
20MST41.99825162
21ADRBK21.97599834
22IRAK11.89156841
23SIK31.72787254
24PIM21.72785325
25MUSK1.64475126
26BCKDK1.63813446
27IRAK21.61119620
28BLK1.48913771
29TNIK1.47119480
30RIPK41.45047532
31PINK11.43813564
32BCR1.43242707
33STK391.43144870
34GRK51.41372329
35CSNK1G31.40566037
36NEK61.34633007
37VRK11.34109294
38TRIM281.33252394
39CSNK1G21.29819166
40CSNK1G11.29450434
41EPHA31.29309495
42CAMKK21.26232658
43IKBKB1.24293429
44MAP2K71.23044536
45TLK11.21574689
46STK241.19094124
47MYLK1.16001900
48EIF2AK21.15192134
49PKN11.14444501
50TEC1.13928776
51NEK11.12127981
52NLK1.10066298
53KDR1.08430061
54EIF2AK31.08271511
55IKBKE1.07103268
56NUAK11.05884653
57BUB11.01234701
58TESK20.98081643
59GRK10.95577449
60CSNK1A1L0.95562564
61PRKCE0.95540587
62BRSK20.94794889
63MAP3K40.92734895
64SRPK10.91936476
65YES10.90693303
66PAK30.90043892
67MKNK20.89874087
68PLK30.89161040
69DYRK20.87286094
70OXSR10.87108949
71ACVR1B0.83085914
72PHKG10.80475944
73PHKG20.80475944
74EPHB10.78924338
75MAP3K130.78202457
76PLK40.75905570
77SYK0.74507276
78PRKCG0.72863694
79EIF2AK10.72134009
80WNK40.72098212
81FGR0.71247616
82PLK20.70573253
83TYK20.70385161
84FES0.70323605
85PIK3CA0.70278919
86TBK10.69949471
87MST1R0.67783829
88LYN0.67078089
89PRPF4B0.65515757
90JAK30.64610334
91ARAF0.62106636
92CDK80.61196443
93MAPK130.60894716
94ADRBK10.60633174
95MAPKAPK50.59604880
96DAPK10.59553699
97INSRR0.59157049
98CLK10.58332636
99MARK30.58009041
100TAF10.57306511
101TESK10.56990195
102CDC70.56723379
103OBSCN0.55593247
104CAMK2B0.55384552
105MAPK150.54299374
106CAMKK10.54195906
107PDK20.52984439
108PRKCD0.52453201
109CAMK2D0.52359275
110CDK190.52153717
111PRKCI0.51617564
112AKT30.51608751
113TGFBR10.50671887
114LRRK20.50372720
115PLK10.49853564
116PRKCQ0.49541717
117CAMK2G0.49121568
118LIMK10.48638375
119ZAP700.46995140
120PRKACA0.46969310
121TRPM70.46926840
122CAMK2A0.46925664
123LCK0.46904764
124CSNK1A10.46557104
125DAPK30.45344183
126KIT0.45298732
127PIK3CG0.45213176
128RPS6KA50.42374723
129CSNK2A20.42285334
130PRKCA0.42214323
131CSNK2A10.42009176
132ERBB30.40806561
133DAPK20.40448455
134MARK10.40239828
135BTK0.40042232
136BRAF0.38695148
137MINK10.37815921
138TAOK30.36157606
139ABL20.35997673
140TIE10.35987835
141STK38L0.35352265
142SGK2230.35236716
143SGK4940.35236716

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.28947587
2Proteasome_Homo sapiens_hsa030503.35478557
3Parkinsons disease_Homo sapiens_hsa050123.20591177
4Protein export_Homo sapiens_hsa030603.07189947
5Ribosome_Homo sapiens_hsa030102.67497205
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.59415188
7Alzheimers disease_Homo sapiens_hsa050102.56769303
8Huntingtons disease_Homo sapiens_hsa050162.40125826
9Graft-versus-host disease_Homo sapiens_hsa053322.39964474
10Allograft rejection_Homo sapiens_hsa053302.28842118
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.23737871
12Rheumatoid arthritis_Homo sapiens_hsa053232.22974882
13Collecting duct acid secretion_Homo sapiens_hsa049662.07359410
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98003093
15RNA polymerase_Homo sapiens_hsa030201.89974881
16Autoimmune thyroid disease_Homo sapiens_hsa053201.77478764
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.69708374
18Asthma_Homo sapiens_hsa053101.63387289
19* SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59605343
20Folate biosynthesis_Homo sapiens_hsa007901.58669301
21Arachidonic acid metabolism_Homo sapiens_hsa005901.55533681
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55416396
23Caffeine metabolism_Homo sapiens_hsa002321.39709585
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.39483391
25Linoleic acid metabolism_Homo sapiens_hsa005911.36555640
26Ether lipid metabolism_Homo sapiens_hsa005651.35309393
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32581393
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30818306
29Sphingolipid metabolism_Homo sapiens_hsa006001.30252423
30Vibrio cholerae infection_Homo sapiens_hsa051101.29977528
31Butanoate metabolism_Homo sapiens_hsa006501.28293088
32Phagosome_Homo sapiens_hsa041451.27926031
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25830779
34Mismatch repair_Homo sapiens_hsa034301.25770343
35Nitrogen metabolism_Homo sapiens_hsa009101.23689094
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21362409
37One carbon pool by folate_Homo sapiens_hsa006701.19650725
38Propanoate metabolism_Homo sapiens_hsa006401.18365392
39Other glycan degradation_Homo sapiens_hsa005111.17565718
40Malaria_Homo sapiens_hsa051441.17551973
41Steroid biosynthesis_Homo sapiens_hsa001001.16775885
42African trypanosomiasis_Homo sapiens_hsa051431.16656067
43Leishmaniasis_Homo sapiens_hsa051401.16234735
44RNA degradation_Homo sapiens_hsa030181.15295987
45Type I diabetes mellitus_Homo sapiens_hsa049401.13829759
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12127660
47Hematopoietic cell lineage_Homo sapiens_hsa046401.10755440
48Peroxisome_Homo sapiens_hsa041461.10754797
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10445781
50Pertussis_Homo sapiens_hsa051331.09046342
51Fatty acid elongation_Homo sapiens_hsa000621.08414216
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07697958
53Nucleotide excision repair_Homo sapiens_hsa034201.04703671
54Basal transcription factors_Homo sapiens_hsa030221.03786385
55Homologous recombination_Homo sapiens_hsa034401.02843181
56Sulfur metabolism_Homo sapiens_hsa009201.01895326
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01521487
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01118031
59Tryptophan metabolism_Homo sapiens_hsa003801.00562317
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97887893
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97583132
62Pyrimidine metabolism_Homo sapiens_hsa002400.96087559
63Measles_Homo sapiens_hsa051620.95834269
64Cardiac muscle contraction_Homo sapiens_hsa042600.95827478
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95549196
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94308906
67Legionellosis_Homo sapiens_hsa051340.91921626
68Regulation of autophagy_Homo sapiens_hsa041400.90220514
69Selenocompound metabolism_Homo sapiens_hsa004500.86947721
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86692040
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85399300
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84955566
73Primary immunodeficiency_Homo sapiens_hsa053400.81544878
74Histidine metabolism_Homo sapiens_hsa003400.79884366
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.79085380
76Tuberculosis_Homo sapiens_hsa051520.77715619
77Lysosome_Homo sapiens_hsa041420.74463605
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72779127
79DNA replication_Homo sapiens_hsa030300.72494421
80Base excision repair_Homo sapiens_hsa034100.71250533
81Nicotine addiction_Homo sapiens_hsa050330.70790342
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68990376
83Phototransduction_Homo sapiens_hsa047440.68423686
84Glutathione metabolism_Homo sapiens_hsa004800.67738053
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67396856
86Influenza A_Homo sapiens_hsa051640.67240860
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67205706
88Purine metabolism_Homo sapiens_hsa002300.66712335
89Non-homologous end-joining_Homo sapiens_hsa034500.66650221
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65299307
91TNF signaling pathway_Homo sapiens_hsa046680.64156698
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.63994526
93Vitamin digestion and absorption_Homo sapiens_hsa049770.63825992
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63163369
95Salmonella infection_Homo sapiens_hsa051320.63058273
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62963233
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62146284
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60899000
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.60810881
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60571549
101Serotonergic synapse_Homo sapiens_hsa047260.59470725
102Mineral absorption_Homo sapiens_hsa049780.56995010
103Retinol metabolism_Homo sapiens_hsa008300.56811752
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55401655
105Herpes simplex infection_Homo sapiens_hsa051680.54188489
106Taste transduction_Homo sapiens_hsa047420.53069577
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52930904
108Osteoclast differentiation_Homo sapiens_hsa043800.52874195
109Epstein-Barr virus infection_Homo sapiens_hsa051690.52733339
110Metabolic pathways_Homo sapiens_hsa011000.51112808
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.50403026
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.50085123
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49125320
114Fanconi anemia pathway_Homo sapiens_hsa034600.48849708
115Spliceosome_Homo sapiens_hsa030400.47983652
116Hepatitis C_Homo sapiens_hsa051600.44367834
117Olfactory transduction_Homo sapiens_hsa047400.43068416
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42101685
119beta-Alanine metabolism_Homo sapiens_hsa004100.41897701
120Staphylococcus aureus infection_Homo sapiens_hsa051500.41122755
121Chemical carcinogenesis_Homo sapiens_hsa052040.39979256
122Fatty acid degradation_Homo sapiens_hsa000710.38013299
123Tyrosine metabolism_Homo sapiens_hsa003500.37174812
124Pyruvate metabolism_Homo sapiens_hsa006200.37032852
125GABAergic synapse_Homo sapiens_hsa047270.36808560
126Chemokine signaling pathway_Homo sapiens_hsa040620.36218062
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.36194791
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.36064891
129RNA transport_Homo sapiens_hsa030130.34135307
130Morphine addiction_Homo sapiens_hsa050320.33920091
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33423779
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31010712
133Phenylalanine metabolism_Homo sapiens_hsa003600.29847303
134Antigen processing and presentation_Homo sapiens_hsa046120.29708182
135Synaptic vesicle cycle_Homo sapiens_hsa047210.29464112
136Sulfur relay system_Homo sapiens_hsa041220.26338928
137Fat digestion and absorption_Homo sapiens_hsa049750.24294938
138Apoptosis_Homo sapiens_hsa042100.22838706
139Toxoplasmosis_Homo sapiens_hsa051450.21445198

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