STX8P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)7.70641563
2snRNA processing (GO:0016180)7.37981879
3snRNA metabolic process (GO:0016073)6.68196683
4kinetochore organization (GO:0051383)6.57911382
5histone H3-K4 trimethylation (GO:0080182)6.35537963
6inner ear receptor stereocilium organization (GO:0060122)5.86929290
7peptidyl-threonine dephosphorylation (GO:0035970)5.56713348
8mitochondrion degradation (GO:0000422)5.48679078
9reciprocal meiotic recombination (GO:0007131)5.36860992
10reciprocal DNA recombination (GO:0035825)5.36860992
11kinetochore assembly (GO:0051382)5.16518818
12rRNA catabolic process (GO:0016075)4.97252593
13mismatch repair (GO:0006298)4.94359155
14UDP-N-acetylglucosamine metabolic process (GO:0006047)4.94310419
15mitotic chromosome condensation (GO:0007076)4.84908148
16fucose catabolic process (GO:0019317)4.81152114
17L-fucose metabolic process (GO:0042354)4.81152114
18L-fucose catabolic process (GO:0042355)4.81152114
19acrosome assembly (GO:0001675)4.79205975
20positive regulation of triglyceride biosynthetic process (GO:0010867)4.72924027
21positive regulation of vasculogenesis (GO:2001214)4.72032144
22DNA double-strand break processing (GO:0000729)4.68728579
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.64154623
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.64154623
25positive regulation of mitotic sister chromatid separation (GO:1901970)4.64154623
26positive regulation of cytokinesis (GO:0032467)4.62102838
27peptidyl-lysine trimethylation (GO:0018023)4.56654949
28regulation of MHC class II biosynthetic process (GO:0045346)4.54421277
29regulation of meiosis I (GO:0060631)4.33158215
30auditory receptor cell stereocilium organization (GO:0060088)4.29961652
31positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.01838109
32mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.01838109
33replication fork processing (GO:0031297)3.96887287
34sister chromatid segregation (GO:0000819)3.89901761
35interkinetic nuclear migration (GO:0022027)3.89613698
36metaphase plate congression (GO:0051310)3.87261703
37positive regulation of histone H3-K4 methylation (GO:0051571)3.87187330
38mitotic metaphase plate congression (GO:0007080)3.85465361
39regulation of vasculogenesis (GO:2001212)3.80745849
40C-terminal protein lipidation (GO:0006501)3.79612813
41vesicle targeting (GO:0006903)3.71727576
42mitotic sister chromatid segregation (GO:0000070)3.65691243
43photoreceptor cell maintenance (GO:0045494)3.64574970
44negative regulation of fatty acid biosynthetic process (GO:0045717)3.64031905
45DNA topological change (GO:0006265)3.62784242
46regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.60918173
47recombinational repair (GO:0000725)3.57744646
48double-strand break repair via homologous recombination (GO:0000724)3.56245823
49peptidyl-lysine methylation (GO:0018022)3.53460172
50establishment of chromosome localization (GO:0051303)3.53180351
51female gamete generation (GO:0007292)3.53113184
52chromosome condensation (GO:0030261)3.52169430
53carnitine metabolic process (GO:0009437)3.49486877
54kynurenine metabolic process (GO:0070189)3.48960803
55negative regulation of meiosis (GO:0045835)3.46901961
56response to pheromone (GO:0019236)3.43023167
57maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.40583741
58regulation of triglyceride biosynthetic process (GO:0010866)3.40011146
59indole-containing compound catabolic process (GO:0042436)3.38664216
60indolalkylamine catabolic process (GO:0046218)3.38664216
61tryptophan catabolic process (GO:0006569)3.38664216
62retinal cone cell development (GO:0046549)3.38598400
63monoubiquitinated protein deubiquitination (GO:0035520)3.38484394
64N-acetylneuraminate metabolic process (GO:0006054)3.38399469
65granulocyte differentiation (GO:0030851)3.38383098
66protein K6-linked ubiquitination (GO:0085020)3.37783389
67positive regulation of mitochondrial fission (GO:0090141)3.32017363
68centrosome duplication (GO:0051298)3.31447248
69chromosome organization involved in meiosis (GO:0070192)3.24111583
70chromosome segregation (GO:0007059)3.22913956
71peptidyl-histidine modification (GO:0018202)3.22766945
72C-terminal protein amino acid modification (GO:0018410)3.21220149
73DNA packaging (GO:0006323)3.20735653
74ncRNA catabolic process (GO:0034661)3.18644851
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18119052
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.18119052
77phosphatidylinositol acyl-chain remodeling (GO:0036149)3.16344625
78cell proliferation in forebrain (GO:0021846)3.12303271
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09979172
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09928445
81positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.09308740
82lung vasculature development (GO:0060426)3.08925436
83DNA replication initiation (GO:0006270)3.08590403
84DNA ligation (GO:0006266)3.06854653
85positive regulation of defense response to virus by host (GO:0002230)3.06404675
86regulation of mitotic spindle organization (GO:0060236)3.02626384
87positive regulation of neuroblast proliferation (GO:0002052)3.01299186
88rRNA methylation (GO:0031167)2.99913269
89positive regulation of chromosome segregation (GO:0051984)2.95103698
90axoneme assembly (GO:0035082)2.94419244
91meiotic cell cycle process (GO:1903046)2.91270165
92regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.88811529
93somite development (GO:0061053)2.86527537
94negative regulation of NF-kappaB import into nucleus (GO:0042347)2.85801200
95cellular protein catabolic process (GO:0044257)2.83069860
96phosphatidylserine acyl-chain remodeling (GO:0036150)2.80423576
97interleukin-6-mediated signaling pathway (GO:0070102)2.80253421
98resolution of meiotic recombination intermediates (GO:0000712)2.79612129
99autophagic vacuole assembly (GO:0000045)2.78115376
100meiotic chromosome segregation (GO:0045132)13.5534678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.47584497
2MYCN_21190229_ChIP-Seq_SHEP-21N_Human4.49722872
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.06812943
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.51490781
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.34231212
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86220116
7GBX2_23144817_ChIP-Seq_PC3_Human2.81193941
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.67522676
9EWS_26573619_Chip-Seq_HEK293_Human2.64479153
10ZNF274_21170338_ChIP-Seq_K562_Hela2.34676700
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28017053
12TAF15_26573619_Chip-Seq_HEK293_Human2.15821520
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.06909491
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01072029
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.94915784
16TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94915784
17FUS_26573619_Chip-Seq_HEK293_Human1.92116651
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91467970
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81402525
20BCAT_22108803_ChIP-Seq_LS180_Human1.76722890
21VDR_22108803_ChIP-Seq_LS180_Human1.74632850
22MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.72548445
23TCF4_23295773_ChIP-Seq_U87_Human1.68948305
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.68061986
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.66202842
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63210118
27MYC_18940864_ChIP-ChIP_HL60_Human1.60010970
28P300_19829295_ChIP-Seq_ESCs_Human1.56005228
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44865540
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.43653499
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43077378
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.42645120
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41811709
34IRF1_19129219_ChIP-ChIP_H3396_Human1.41132332
35ER_23166858_ChIP-Seq_MCF-7_Human1.40829176
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39917700
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39753689
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38775916
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32654957
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32463356
41IGF1R_20145208_ChIP-Seq_DFB_Human1.30954472
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30580080
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30556381
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.30411888
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27524520
46HOXB7_26014856_ChIP-Seq_BT474_Human1.26613237
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24244905
48AR_21909140_ChIP-Seq_LNCAP_Human1.23908589
49STAT3_23295773_ChIP-Seq_U87_Human1.22813363
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.21973299
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21813087
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21706046
53AR_21572438_ChIP-Seq_LNCaP_Human1.20603775
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19366175
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18696903
56SMAD4_21799915_ChIP-Seq_A2780_Human1.18228210
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17268318
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16740144
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16064415
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15889437
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15540452
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14718813
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.13370591
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12673049
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12660880
66LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10940503
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09646232
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09015036
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08487954
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.08487954
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.08474750
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.08333896
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08238319
74TP53_22573176_ChIP-Seq_HFKS_Human1.08106376
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06226033
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06029655
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05137808
78CBP_20019798_ChIP-Seq_JUKART_Human1.05137808
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05062513
80AR_20517297_ChIP-Seq_VCAP_Human1.04883531
81AR_25329375_ChIP-Seq_VCAP_Human1.03994484
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03156265
83SOX9_26525672_Chip-Seq_HEART_Mouse1.00627636
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00134471
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99890811
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98581302
87TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98509501
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98430416
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.98273440
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98196270
91TAL1_26923725_Chip-Seq_HPCs_Mouse0.97982071
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96412496
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.96327541
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.94690553
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.93916962
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93464382
97FOXP3_21729870_ChIP-Seq_TREG_Human0.92987311
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92547950
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91662835
100OCT1_27270436_Chip-Seq_PROSTATE_Human0.91629998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.41554216
2MP0005310_abnormal_salivary_gland3.19628348
3MP0003718_maternal_effect3.10658416
4MP0005646_abnormal_pituitary_gland3.10391190
5MP0006072_abnormal_retinal_apoptosis2.96081694
6MP0003646_muscle_fatigue2.87941057
7MP0006292_abnormal_olfactory_placode2.85764284
8MP0010094_abnormal_chromosome_stability2.79183767
9MP0004484_altered_response_of2.74956472
10MP0008058_abnormal_DNA_repair2.62239751
11MP0009764_decreased_sensitivity_to2.44710149
12MP0008877_abnormal_DNA_methylation2.42122261
13MP0005085_abnormal_gallbladder_physiolo2.34308278
14MP0005365_abnormal_bile_salt2.33829718
15MP0005360_urolithiasis2.24574652
16MP0005551_abnormal_eye_electrophysiolog2.22078349
17MP0009697_abnormal_copulation2.18503889
18MP0002928_abnormal_bile_duct2.10523041
19MP0000383_abnormal_hair_follicle2.07588331
20MP0005409_darkened_coat_color1.89342116
21MP0008961_abnormal_basal_metabolism1.84679260
22MP0005253_abnormal_eye_physiology1.82291143
23MP0008872_abnormal_physiological_respon1.76827241
24MP0003195_calcinosis1.72562779
25MP0003937_abnormal_limbs/digits/tail_de1.69475517
26MP0009053_abnormal_anal_canal1.66168480
27MP0000566_synostosis1.63214148
28MP0000427_abnormal_hair_cycle1.63102020
29MP0003011_delayed_dark_adaptation1.61389821
30MP0005395_other_phenotype1.57807584
31MP0001764_abnormal_homeostasis1.56261118
32MP0004742_abnormal_vestibular_system1.53853424
33MP0000631_abnormal_neuroendocrine_gland1.51340114
34MP0003111_abnormal_nucleus_morphology1.48586819
35MP0003787_abnormal_imprinting1.47139035
36MP0001346_abnormal_lacrimal_gland1.45844924
37MP0003136_yellow_coat_color1.43672607
38MP0003077_abnormal_cell_cycle1.43490591
39MP0010307_abnormal_tumor_latency1.40236352
40MP0002210_abnormal_sex_determination1.32750471
41MP0005410_abnormal_fertilization1.31400246
42MP0001119_abnormal_female_reproductive1.27447122
43MP0008057_abnormal_DNA_replication1.23782776
44MP0002234_abnormal_pharynx_morphology1.23719040
45MP0005167_abnormal_blood-brain_barrier1.21134989
46MP0002557_abnormal_social/conspecific_i1.19136872
47MP0003880_abnormal_central_pattern1.17714987
48MP0001929_abnormal_gametogenesis1.17236991
49MP0001177_atelectasis1.16573529
50MP0009745_abnormal_behavioral_response1.12386595
51MP0004885_abnormal_endolymph1.11945366
52MP0002876_abnormal_thyroid_physiology1.11493002
53MP0004957_abnormal_blastocyst_morpholog1.09603503
54MP0000653_abnormal_sex_gland1.08427898
55MP0003698_abnormal_male_reproductive1.08276453
56MP0005248_abnormal_Harderian_gland1.06513850
57MP0005195_abnormal_posterior_eye1.05315078
58MP0008875_abnormal_xenobiotic_pharmacok1.03561410
59MP0001486_abnormal_startle_reflex1.03090349
60MP0002653_abnormal_ependyma_morphology1.01950268
61MP0001286_abnormal_eye_development1.01816017
62MP0000026_abnormal_inner_ear1.01110279
63MP0010678_abnormal_skin_adnexa1.00345873
64MP0002090_abnormal_vision0.99161479
65MP0004782_abnormal_surfactant_physiolog0.98237520
66MP0008789_abnormal_olfactory_epithelium0.96774176
67MP0001145_abnormal_male_reproductive0.95569478
68MP0003938_abnormal_ear_development0.94900296
69MP0001986_abnormal_taste_sensitivity0.93873251
70MP0008775_abnormal_heart_ventricle0.93560063
71MP0002938_white_spotting0.92838878
72MP0000428_abnormal_craniofacial_morphol0.92383589
73MP0005647_abnormal_sex_gland0.90938422
74MP0005391_vision/eye_phenotype0.88911400
75MP0003693_abnormal_embryo_hatching0.88616608
76MP0003755_abnormal_palate_morphology0.87529114
77MP0004215_abnormal_myocardial_fiber0.87505904
78MP0003699_abnormal_female_reproductive0.85629247
79MP0001502_abnormal_circadian_rhythm0.85346457
80MP0010329_abnormal_lipoprotein_level0.84526703
81MP0002168_other_aberrant_phenotype0.84303881
82MP0008932_abnormal_embryonic_tissue0.82333057
83MP0002098_abnormal_vibrissa_morphology0.81762912
84MP0001324_abnormal_eye_pigmentation0.80449909
85MP0000647_abnormal_sebaceous_gland0.75523403
86MP0004085_abnormal_heartbeat0.72030078
87MP0009115_abnormal_fat_cell0.71949003
88MP0001501_abnormal_sleep_pattern0.70974841
89MP0009643_abnormal_urine_homeostasis0.70487811
90MP0005332_abnormal_amino_acid0.69683945
91MP0005165_increased_susceptibility_to0.68113087
92MP0003861_abnormal_nervous_system0.65819230
93MP0000778_abnormal_nervous_system0.65061145
94MP0002075_abnormal_coat/hair_pigmentati0.63178093
95MP0002161_abnormal_fertility/fecundity0.61664388
96MP0002282_abnormal_trachea_morphology0.60855729
97MP0004133_heterotaxia0.60843981
98MP0002752_abnormal_somatic_nervous0.59029619
99MP0002693_abnormal_pancreas_physiology0.58802924
100MP0001293_anophthalmia0.58564257

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)7.20360042
2Abnormal rod and cone electroretinograms (HP:0008323)5.46825220
3Pigmentary retinal degeneration (HP:0001146)5.14474781
4Abnormal biliary tract physiology (HP:0012439)4.38404434
5Bile duct proliferation (HP:0001408)4.38404434
6Ependymoma (HP:0002888)4.10861883
7Pancreatic cysts (HP:0001737)3.80171815
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.79040667
9Pancreatic fibrosis (HP:0100732)3.54676671
10Decreased central vision (HP:0007663)3.46544781
11Molar tooth sign on MRI (HP:0002419)3.43167919
12Abnormality of midbrain morphology (HP:0002418)3.43167919
13Attenuation of retinal blood vessels (HP:0007843)3.41973120
14Chronic bronchitis (HP:0004469)3.38918458
15True hermaphroditism (HP:0010459)3.29692586
16Short 4th metacarpal (HP:0010044)3.18052266
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.18052266
18Hepatocellular necrosis (HP:0001404)3.10375208
19Bony spicule pigmentary retinopathy (HP:0007737)3.06435197
20Tubular atrophy (HP:0000092)3.02116307
21Choroideremia (HP:0001139)3.00367249
22Sloping forehead (HP:0000340)2.98078392
23Vitreoretinal degeneration (HP:0000655)2.88215679
24Chronic hepatic failure (HP:0100626)2.87170392
25Flat occiput (HP:0005469)2.86677985
26Astrocytoma (HP:0009592)2.86371058
27Abnormality of the astrocytes (HP:0100707)2.86371058
28Polydipsia (HP:0001959)2.77058574
29Abnormal drinking behavior (HP:0030082)2.77058574
30Glioma (HP:0009733)2.72593548
31Cystic liver disease (HP:0006706)2.72472012
32Abnormality of the ileum (HP:0001549)2.67147441
33Aplasia/Hypoplasia of the spleen (HP:0010451)2.54892092
34Intestinal atresia (HP:0011100)2.54136164
35Meckel diverticulum (HP:0002245)2.52912616
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.52563853
37Dyschromatopsia (HP:0007641)2.50836163
38Abnormality of the renal cortex (HP:0011035)2.50784615
39Nephronophthisis (HP:0000090)2.50619881
40Asplenia (HP:0001746)2.47410408
41Abnormality of the aortic arch (HP:0012303)2.45725291
42Biliary tract neoplasm (HP:0100574)2.43214717
43Congenital stationary night blindness (HP:0007642)2.41629013
44Supernumerary spleens (HP:0009799)2.39359678
45Decreased circulating renin level (HP:0003351)2.38762154
46Hepatic necrosis (HP:0002605)2.34043122
47Abnormality of the renal medulla (HP:0100957)2.33272724
48Anencephaly (HP:0002323)2.30843939
49Thyroid-stimulating hormone excess (HP:0002925)2.29254733
50Hypoplastic nipples (HP:0002557)2.28808237
51Abnormal biliary tract morphology (HP:0012440)2.28314377
52Abnormality of the phalanges of the hallux (HP:0010057)2.28194765
53Hypopigmentation of the fundus (HP:0007894)2.26393856
54Colon cancer (HP:0003003)2.24114307
55Small intestinal stenosis (HP:0012848)2.21878699
56Duodenal stenosis (HP:0100867)2.21878699
57Abnormality of the 4th metacarpal (HP:0010012)2.21683837
58Abnormality of incisor morphology (HP:0011063)2.20650065
59Abnormality of the duodenum (HP:0002246)2.19296965
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18702342
61Abnormality of alanine metabolism (HP:0010916)2.18702342
62Hyperalaninemia (HP:0003348)2.18702342
63Cortical dysplasia (HP:0002539)2.17704801
64Abnormality of the labia minora (HP:0012880)2.16698727
65Abnormality of chromosome stability (HP:0003220)2.15360750
66Hypoplastic iliac wings (HP:0002866)2.14269404
67Ectopic kidney (HP:0000086)2.13075419
68Clubbing of toes (HP:0100760)2.11606049
69Acute necrotizing encephalopathy (HP:0006965)2.11485032
70Postaxial foot polydactyly (HP:0001830)2.11254296
71Congenital hepatic fibrosis (HP:0002612)2.09455716
72Abnormal lung lobation (HP:0002101)2.08124424
73Retinitis pigmentosa (HP:0000510)2.05421583
74Lymphangioma (HP:0100764)2.01982609
75Abnormality of the proximal phalanges of the hand (HP:0009834)1.99298787
76Aplasia/Hypoplasia of the fovea (HP:0008060)1.96464594
77Hypoplasia of the fovea (HP:0007750)1.96464594
78Abnormality of the preputium (HP:0100587)1.96109197
79Hypocalcemia (HP:0002901)1.94261478
802-3 toe syndactyly (HP:0004691)1.93975339
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.93837688
82Dandy-Walker malformation (HP:0001305)1.90573870
83Central scotoma (HP:0000603)1.90152019
84Pendular nystagmus (HP:0012043)1.87807668
85Volvulus (HP:0002580)1.85617463
86Chromsome breakage (HP:0040012)1.83067436
87Neoplasm of striated muscle (HP:0009728)1.81819616
88Aqueductal stenosis (HP:0002410)1.81083715
89Abnormality of the carotid arteries (HP:0005344)1.80710018
90Cerebellar dysplasia (HP:0007033)1.80483956
91Polyuria (HP:0000103)1.80124548
92Astigmatism (HP:0000483)1.78869124
93Rimmed vacuoles (HP:0003805)1.78498652
94Severe Myopia (HP:0011003)1.77370177
95Benign neoplasm of the central nervous system (HP:0100835)1.77281234
96Patellar aplasia (HP:0006443)1.75663973
97Preaxial hand polydactyly (HP:0001177)1.75144547
98Abnormal mitochondria in muscle tissue (HP:0008316)1.74379097
99Occipital encephalocele (HP:0002085)1.72308649
100Neoplasm of the colon (HP:0100273)1.70562372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK6.77235875
2CCNB15.34450602
3FRK4.00870845
4MAP3K94.00549450
5ZAK2.94347606
6CAMK1D2.77474956
7WEE12.62596281
8CAMK1G2.36459145
9CAMKK22.25863292
10NUAK12.01258375
11NEK21.98688837
12BRSK21.87994264
13EPHA41.80863481
14BMPR1B1.68357532
15MELK1.60368244
16MKNK21.54741016
17GRK11.54108214
18MARK31.52456508
19STK31.47552514
20PLK11.47074214
21PLK31.43127937
22BRSK11.39123316
23PKN21.37882017
24MAPKAPK51.34780276
25CDC71.34225812
26MAP4K21.33868398
27HIPK21.31657483
28PDK11.26827267
29CAMK41.24215402
30MAP3K101.22577280
31WNK41.18451856
32TAF11.16226774
33RPS6KA41.10730114
34PDPK11.08489921
35FLT31.08411281
36STK391.06395490
37BUB11.05215105
38PINK10.95624783
39LATS10.93323792
40MAP3K40.92767284
41PKN10.88630486
42ATR0.87357695
43TTK0.85577514
44EPHA30.82869072
45TNK20.82303985
46FGFR20.78272040
47PLK40.75336491
48ERBB20.72036426
49VRK10.71316172
50PRKCI0.71018432
51CDK90.69372457
52AURKB0.69161482
53INSRR0.67040912
54MKNK10.66042377
55WNK30.65141928
56MAPK130.64531847
57ACVR1B0.64170217
58SGK20.59417109
59CHEK20.59395281
60CSNK1E0.58499357
61PRKCE0.56612406
62GSK3A0.55245212
63NTRK20.54323951
64PNCK0.54101210
65EPHB20.53009956
66DYRK20.52872616
67VRK20.52295730
68CDK10.51190251
69DYRK30.49153045
70ADRBK20.48802475
71MAP2K70.47355396
72SGK30.45552910
73STK38L0.44660102
74ATM0.42672582
75PLK20.42016707
76CAMK10.40901346
77PRKAA10.39527272
78NEK10.38297303
79TLK10.37724839
80CAMKK10.37590766
81ROCK10.36441792
82TGFBR10.35938694
83SGK10.34935705
84DAPK20.34629274
85BMX0.33971063
86PRKCG0.33852889
87MAP3K80.33479940
88PRKD20.32265169
89BRD40.31964431
90CLK10.30709180
91RPS6KA60.29672792
92UHMK10.28325016
93FGFR10.28139383
94PRKCQ0.27990611
95SGK4940.27564804
96SGK2230.27564804
97MAPKAPK30.26615870
98CHEK10.25588143
99STK110.25217353
100PRKCZ0.24808927

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of autophagy_Homo sapiens_hsa041404.09216239
2Caffeine metabolism_Homo sapiens_hsa002323.35371069
3Linoleic acid metabolism_Homo sapiens_hsa005913.34267869
4Propanoate metabolism_Homo sapiens_hsa006403.30162038
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91354134
6Fanconi anemia pathway_Homo sapiens_hsa034602.88978910
7Homologous recombination_Homo sapiens_hsa034402.76754624
8Non-homologous end-joining_Homo sapiens_hsa034502.71648406
9Base excision repair_Homo sapiens_hsa034102.62741329
10Mismatch repair_Homo sapiens_hsa034302.60776123
11Lysine degradation_Homo sapiens_hsa003102.26755594
12Cysteine and methionine metabolism_Homo sapiens_hsa002702.06325417
13One carbon pool by folate_Homo sapiens_hsa006702.03873568
14Selenocompound metabolism_Homo sapiens_hsa004502.00125913
15Fatty acid degradation_Homo sapiens_hsa000711.99622875
16Cell cycle_Homo sapiens_hsa041101.90460459
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72096172
18Ether lipid metabolism_Homo sapiens_hsa005651.71807609
19Pyruvate metabolism_Homo sapiens_hsa006201.71267148
20Fatty acid metabolism_Homo sapiens_hsa012121.69238436
21Tryptophan metabolism_Homo sapiens_hsa003801.63860553
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58792876
23Phototransduction_Homo sapiens_hsa047441.53364296
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.52815174
25FoxO signaling pathway_Homo sapiens_hsa040681.49723198
26Ovarian steroidogenesis_Homo sapiens_hsa049131.37633540
27Butanoate metabolism_Homo sapiens_hsa006501.34416411
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29921067
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.21976706
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16192319
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14709408
32Arachidonic acid metabolism_Homo sapiens_hsa005901.11793095
33PPAR signaling pathway_Homo sapiens_hsa033201.11463953
34Nicotine addiction_Homo sapiens_hsa050331.10700054
35Steroid biosynthesis_Homo sapiens_hsa001001.09877485
36p53 signaling pathway_Homo sapiens_hsa041151.08140695
37Basal transcription factors_Homo sapiens_hsa030221.07497188
38Hedgehog signaling pathway_Homo sapiens_hsa043401.04296930
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02559917
40Morphine addiction_Homo sapiens_hsa050320.96606748
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92758165
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92568915
43Staphylococcus aureus infection_Homo sapiens_hsa051500.88182794
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87409528
45Primary immunodeficiency_Homo sapiens_hsa053400.82626182
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79720591
47Taste transduction_Homo sapiens_hsa047420.78446533
48Fat digestion and absorption_Homo sapiens_hsa049750.75375718
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74404192
50Nitrogen metabolism_Homo sapiens_hsa009100.73353290
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72131094
52Olfactory transduction_Homo sapiens_hsa047400.68675315
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67832202
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.65737086
55RNA degradation_Homo sapiens_hsa030180.65372693
56Retinol metabolism_Homo sapiens_hsa008300.60759648
57Oocyte meiosis_Homo sapiens_hsa041140.59396408
58Glucagon signaling pathway_Homo sapiens_hsa049220.58945423
59Mineral absorption_Homo sapiens_hsa049780.58391754
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57667521
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52143250
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51131957
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49405838
64Sulfur relay system_Homo sapiens_hsa041220.48939629
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.48364287
66Glutamatergic synapse_Homo sapiens_hsa047240.45262847
67Insulin secretion_Homo sapiens_hsa049110.44505728
68Chemical carcinogenesis_Homo sapiens_hsa052040.43864127
69RNA transport_Homo sapiens_hsa030130.43203292
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41786463
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40741543
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40568190
73Serotonergic synapse_Homo sapiens_hsa047260.39825459
74DNA replication_Homo sapiens_hsa030300.38588928
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38172331
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37941528
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36110622
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34670570
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34297337
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.33920846
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33612358
82Sulfur metabolism_Homo sapiens_hsa009200.33107232
83Basal cell carcinoma_Homo sapiens_hsa052170.32840740
84Metabolic pathways_Homo sapiens_hsa011000.30579520
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.30321966
86Purine metabolism_Homo sapiens_hsa002300.30237738
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29658278
88Thyroid hormone synthesis_Homo sapiens_hsa049180.29377916
89MAPK signaling pathway_Homo sapiens_hsa040100.29251981
90GABAergic synapse_Homo sapiens_hsa047270.28904777
91Choline metabolism in cancer_Homo sapiens_hsa052310.28192285
92Dorso-ventral axis formation_Homo sapiens_hsa043200.28106757
93Asthma_Homo sapiens_hsa053100.27094550
94Salivary secretion_Homo sapiens_hsa049700.26367185
95Nucleotide excision repair_Homo sapiens_hsa034200.26271210
96Glycerolipid metabolism_Homo sapiens_hsa005610.25979619
97MicroRNAs in cancer_Homo sapiens_hsa052060.24630017
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.23543192
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22791445
100Arginine biosynthesis_Homo sapiens_hsa002200.22602903

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