STXBP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.41443504
2synaptic vesicle maturation (GO:0016188)4.88162159
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.79381205
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73014833
5locomotory exploration behavior (GO:0035641)4.72116936
6synaptic vesicle exocytosis (GO:0016079)4.49257598
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.31013170
8definitive hemopoiesis (GO:0060216)4.17258605
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.16517727
10vocalization behavior (GO:0071625)4.12521769
11regulation of glutamate receptor signaling pathway (GO:1900449)4.04044954
12glutamate secretion (GO:0014047)4.02583204
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.00713502
14regulation of synaptic vesicle exocytosis (GO:2000300)3.98541400
15protein localization to synapse (GO:0035418)3.97223499
16glutamate receptor signaling pathway (GO:0007215)3.96119781
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89912616
18cellular potassium ion homeostasis (GO:0030007)3.86979910
19Golgi to endosome transport (GO:0006895)3.82073955
20regulation of ARF protein signal transduction (GO:0032012)3.78481636
21response to histamine (GO:0034776)3.75679647
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.71762238
23regulation of clathrin-mediated endocytosis (GO:2000369)3.68748394
24negative regulation of dendrite morphogenesis (GO:0050774)3.68601221
25synaptic vesicle endocytosis (GO:0048488)3.68522872
26regulation of synaptic vesicle transport (GO:1902803)3.67523846
27exploration behavior (GO:0035640)3.65265599
28iron ion import (GO:0097286)3.57475678
29regulation of neuronal synaptic plasticity (GO:0048168)3.53663504
30synaptic transmission, glutamatergic (GO:0035249)3.52640225
31phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.51686139
32sodium ion export (GO:0071436)3.49614009
33layer formation in cerebral cortex (GO:0021819)3.44669665
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43562328
35cerebellar Purkinje cell differentiation (GO:0021702)3.41100848
36neurotransmitter secretion (GO:0007269)3.37522581
37neuron-neuron synaptic transmission (GO:0007270)3.36887884
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36216618
39negative regulation of cell killing (GO:0031342)3.36216618
40long-term memory (GO:0007616)3.34769000
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.33364981
42neuronal action potential propagation (GO:0019227)3.31071285
43neuron cell-cell adhesion (GO:0007158)3.30243805
44regulation of postsynaptic membrane potential (GO:0060078)3.30089493
45G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.28655297
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24147793
47regulation of synapse structural plasticity (GO:0051823)3.21908702
48proline transport (GO:0015824)3.19578495
49phospholipid translocation (GO:0045332)3.18776090
50lipid translocation (GO:0034204)3.18776090
51activation of protein kinase A activity (GO:0034199)3.18322773
52detection of calcium ion (GO:0005513)3.18047852
53cellular response to ethanol (GO:0071361)3.18002500
54early endosome to late endosome transport (GO:0045022)3.17864723
55regulation of Rac protein signal transduction (GO:0035020)3.14178363
56vesicle transport along microtubule (GO:0047496)3.14035948
57positive regulation of Rap GTPase activity (GO:0032854)3.09583886
58negative regulation of neurotransmitter secretion (GO:0046929)3.09059866
59positive regulation of membrane potential (GO:0045838)3.08856042
60long-term synaptic potentiation (GO:0060291)3.07606190
61regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.05272542
62negative regulation of erythrocyte differentiation (GO:0045647)3.04899032
63neurotransmitter-gated ion channel clustering (GO:0072578)3.04823564
64regulation of synaptic plasticity (GO:0048167)3.02386114
65monoubiquitinated protein deubiquitination (GO:0035520)3.00234914
66positive regulation of synapse maturation (GO:0090129)2.97014332
67import into cell (GO:0098657)2.93954081
68innervation (GO:0060384)2.92918378
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92894590
70positive regulation of vesicle fusion (GO:0031340)2.91307500
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90624205
72regulation of vesicle fusion (GO:0031338)2.89908227
73protein targeting to Golgi (GO:0000042)2.88906210
74phosphatidylinositol dephosphorylation (GO:0046856)2.88782003
75regulation of beta-amyloid formation (GO:1902003)2.88583722
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86942556
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86334536
78regulation of dendritic spine morphogenesis (GO:0061001)2.85923787
79negative regulation of neurotransmitter transport (GO:0051589)2.85825072
80retrograde transport, vesicle recycling within Golgi (GO:0000301)2.85679988
81dendritic spine morphogenesis (GO:0060997)2.85609698
82interkinetic nuclear migration (GO:0022027)2.84390662
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83903491
84behavioral fear response (GO:0001662)2.83822407
85behavioral defense response (GO:0002209)2.83822407
86establishment of protein localization to Golgi (GO:0072600)2.82829088
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.82445132
88regulation of Rap GTPase activity (GO:0032317)2.81803995
89regulation of neurotransmitter secretion (GO:0046928)2.80319509
90negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80153054
91positive regulation of neurotransmitter secretion (GO:0001956)2.79284666
92membrane depolarization during action potential (GO:0086010)2.79267608
93gamma-aminobutyric acid transport (GO:0015812)2.78186537
94phospholipid dephosphorylation (GO:0046839)2.77562382
95neurotransmitter transport (GO:0006836)2.76426381
96peptidyl-threonine phosphorylation (GO:0018107)2.76049382
97chemosensory behavior (GO:0007635)2.75894583
98membrane depolarization (GO:0051899)2.75540329
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74632729
100cytoplasmic mRNA processing body assembly (GO:0033962)2.73492788
101L-amino acid import (GO:0043092)2.72345350
102neuromuscular process controlling balance (GO:0050885)2.70348974
103dendrite morphogenesis (GO:0048813)2.70192963
104nerve growth factor signaling pathway (GO:0038180)2.69728250
105peptidyl-threonine modification (GO:0018210)2.68792193
106positive regulation of neurotransmitter transport (GO:0051590)2.67992767
107neuron recognition (GO:0008038)2.66555238
108fear response (GO:0042596)2.65998408
109positive regulation of protein autophosphorylation (GO:0031954)2.65111485
110suckling behavior (GO:0001967)2.63098014
111positive regulation of fibroblast migration (GO:0010763)2.62402127
112positive regulation of glycolytic process (GO:0045821)2.62347388
113clathrin coat assembly (GO:0048268)2.60348744
114positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59054358
115macroautophagy (GO:0016236)2.58917736
116mating behavior (GO:0007617)2.58879955
117regulation of dendritic spine development (GO:0060998)2.58126444
118long term synaptic depression (GO:0060292)2.57558240
119regulation of neurotransmitter transport (GO:0051588)2.57423358
120protein targeting to lysosome (GO:0006622)2.56886705
121establishment of protein localization to vacuole (GO:0072666)2.56886705
122protein targeting to vacuole (GO:0006623)2.56886705
123regulation of neurotransmitter levels (GO:0001505)2.54282451
124regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.53881608
125sequestering of extracellular ligand from receptor (GO:0035581)2.52444735
126positive regulation of synaptic transmission (GO:0050806)2.51514046
127learning (GO:0007612)2.49876722
128transmission of nerve impulse (GO:0019226)2.49342256
129inositol phosphate catabolic process (GO:0071545)2.48660727
130axonal fasciculation (GO:0007413)2.48457300
131protein K11-linked deubiquitination (GO:0035871)2.48435658
132intraspecies interaction between organisms (GO:0051703)2.48248488
133social behavior (GO:0035176)2.48248488
134prepulse inhibition (GO:0060134)2.48141961
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.47930228
136neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.46218995
137insulin secretion (GO:0030073)2.44633877
138detection of molecule of bacterial origin (GO:0032490)2.36032950
139positive regulation of cellular amide metabolic process (GO:0034250)2.35827907
140regulation of protein glycosylation (GO:0060049)2.35016133
141response to nerve growth factor (GO:1990089)2.32810510
142cellular response to nerve growth factor stimulus (GO:1990090)2.32810510
143phosphorelay signal transduction system (GO:0000160)2.28819299
144polyol catabolic process (GO:0046174)2.28093358
145regulation of cAMP-dependent protein kinase activity (GO:2000479)2.23897870
146cellular response to epinephrine stimulus (GO:0071872)2.23561482
147negative regulation of dendrite development (GO:2000171)2.21042211
148vesicle docking involved in exocytosis (GO:0006904)2.19121772
149regulation of platelet aggregation (GO:0090330)2.15402454
150positive regulation of gamma-delta T cell activation (GO:0046645)2.15168827
151positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.14871320
152regulation of pigment cell differentiation (GO:0050932)2.13752699
153snRNA transcription (GO:0009301)2.13640896
154regulation of amyloid precursor protein catabolic process (GO:1902991)2.13449336
155positive regulation of granulocyte differentiation (GO:0030854)2.13034105
156response to methylmercury (GO:0051597)2.12853571
157hypotonic response (GO:0006971)2.12517637
158cerebellar granule cell differentiation (GO:0021707)2.12196947
159negative regulation of adherens junction organization (GO:1903392)2.11922736
160negative regulation of focal adhesion assembly (GO:0051895)2.11922736
161negative regulation of cell junction assembly (GO:1901889)2.11922736
162vesicle docking (GO:0048278)2.11595948
163regulation of establishment of cell polarity (GO:2000114)2.11143535
164negative regulation of cytosolic calcium ion concentration (GO:0051481)2.10321442
165positive regulation of macroautophagy (GO:0016239)2.08268612
166cell differentiation in hindbrain (GO:0021533)2.07812111
167positive regulation of insulin receptor signaling pathway (GO:0046628)2.07174223
168regulation of type B pancreatic cell apoptotic process (GO:2000674)2.05640811
169phosphorylated carbohydrate dephosphorylation (GO:0046838)2.05557347
170inositol phosphate dephosphorylation (GO:0046855)2.05557347
171positive regulation of muscle hypertrophy (GO:0014742)2.05332435
172positive regulation of cardiac muscle hypertrophy (GO:0010613)2.05332435
173phosphatidylinositol phosphorylation (GO:0046854)2.04071876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.60862210
2EZH2_22144423_ChIP-Seq_EOC_Human4.60858623
3GBX2_23144817_ChIP-Seq_PC3_Human3.26436960
4DROSHA_22980978_ChIP-Seq_HELA_Human2.50655866
5* RARB_27405468_Chip-Seq_BRAIN_Mouse2.39089717
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30764756
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25712050
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24826210
9GATA1_22025678_ChIP-Seq_K562_Human2.19573816
10REST_21632747_ChIP-Seq_MESCs_Mouse2.17664758
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.09908569
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06703731
13* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04393458
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02063592
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00342902
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97439863
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94296843
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.93766236
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91397571
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91397571
21AR_21572438_ChIP-Seq_LNCaP_Human1.87502266
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82996638
23SMAD4_21799915_ChIP-Seq_A2780_Human1.77925356
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73455708
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72290939
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66570845
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.65563171
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62454684
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.60187629
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59591930
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58031546
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57866680
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57866680
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.57709324
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57312291
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57311505
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57093414
38* RNF2_27304074_Chip-Seq_ESCs_Mouse1.56911644
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55347805
40TP53_16413492_ChIP-PET_HCT116_Human1.54758650
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53658653
42TAF15_26573619_Chip-Seq_HEK293_Human1.52832160
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52491396
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52275507
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52242187
46SCL_19346495_ChIP-Seq_HPC-7_Human1.51258188
47* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48925367
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48834626
49ER_23166858_ChIP-Seq_MCF-7_Human1.48107034
50* STAT3_23295773_ChIP-Seq_U87_Human1.46473990
51* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45886805
52* EZH2_27294783_Chip-Seq_ESCs_Mouse1.43160636
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42500200
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.39266667
55P300_19829295_ChIP-Seq_ESCs_Human1.38941750
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37832811
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36951288
58* AR_25329375_ChIP-Seq_VCAP_Human1.36477526
59IGF1R_20145208_ChIP-Seq_DFB_Human1.36102634
60* GATA2_19941826_ChIP-Seq_K562_Human1.35482418
61BRD4_25478319_ChIP-Seq_HGPS_Human1.35437475
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34188937
63* GATA1_19941826_ChIP-Seq_K562_Human1.33559822
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.33404598
65* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32810727
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32686808
67* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29968324
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.29287792
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.28903042
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28080074
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.27525219
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.27235076
73* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27095278
74VDR_24787735_ChIP-Seq_THP-1_Human1.27072715
75AR_19668381_ChIP-Seq_PC3_Human1.26943372
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26871816
77TCF4_23295773_ChIP-Seq_U87_Human1.26262995
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26075258
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.25570965
80* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24455308
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.24200711
82AHR_22903824_ChIP-Seq_MCF-7_Human1.23393859
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21521611
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.20847881
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20475668
86RXR_22108803_ChIP-Seq_LS180_Human1.19922552
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19428853
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18420467
89* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17788371
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.17399179
91* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17373825
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16776377
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16045071
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15930421
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15561550
96* EZH2_27294783_Chip-Seq_NPCs_Mouse1.15438475
97ZNF274_21170338_ChIP-Seq_K562_Hela1.14794414
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14163760
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12038965
100* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11568927
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11065999
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11055682
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10708305
104P53_22387025_ChIP-Seq_ESCs_Mouse1.10028947
105BCAT_22108803_ChIP-Seq_LS180_Human1.09755106
106* FLI1_21867929_ChIP-Seq_TH2_Mouse1.09706672
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.09688959
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09498823
109KDM2B_26808549_Chip-Seq_K562_Human1.08034751
110CJUN_26792858_Chip-Seq_BT549_Human1.07348987
111RUNX_20019798_ChIP-Seq_JUKART_Human1.07041074
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06954636
113* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05834599
114FUS_26573619_Chip-Seq_HEK293_Human1.04946872
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04020173
116* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03808008
117TP63_23658742_ChIP-Seq_EP156T_Human1.03660144
118SMAD3_21741376_ChIP-Seq_ESCs_Human1.03496774
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03210608
120* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03120828
121* SPI1_23127762_ChIP-Seq_K562_Human1.02764628
122CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02282813
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01974948
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01974948
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01720788
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01302132
127TBL1_22424771_ChIP-Seq_293T_Human1.00785287
128* CDX2_22108803_ChIP-Seq_LS180_Human0.99114432
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98962254
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98229137
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.97982798
132* RUNX2_22187159_ChIP-Seq_PCA_Human0.97599146
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.97062212
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96991672
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96510204
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96012743
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95854436
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95422128
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95364419
140SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94956958
141* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94664845
142KDM2B_26808549_Chip-Seq_REH_Human0.94620567
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91787982
144EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91362273
145KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89539134
146NANOG_18555785_Chip-Seq_ESCs_Mouse0.89502964
147* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88641396
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.86894841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.54675538
2MP0000569_abnormal_digit_pigmentation4.36763839
3MP0003880_abnormal_central_pattern3.99266807
4* MP0003635_abnormal_synaptic_transmissio3.86743388
5MP0004270_analgesia3.29632726
6MP0010352_gastrointestinal_tract_polyps3.14627181
7MP0002063_abnormal_learning/memory/cond3.08701574
8MP0009745_abnormal_behavioral_response3.02533973
9MP0002064_seizures2.89931913
10MP0009046_muscle_twitch2.63857074
11MP0001968_abnormal_touch/_nociception2.63208850
12MP0002572_abnormal_emotion/affect_behav2.56862779
13MP0002009_preneoplasia2.56505130
14MP0008438_abnormal_cutaneous_collagen2.53560310
15MP0004147_increased_porphyrin_level2.36159211
16MP0001501_abnormal_sleep_pattern2.33866258
17MP0001486_abnormal_startle_reflex2.26071290
18MP0009780_abnormal_chondrocyte_physiolo2.23000593
19MP0008057_abnormal_DNA_replication2.21843569
20MP0003172_abnormal_lysosome_physiology2.19705477
21MP0003787_abnormal_imprinting2.17972133
22MP0000013_abnormal_adipose_tissue2.16288453
23MP0005423_abnormal_somatic_nervous2.14774998
24MP0002734_abnormal_mechanical_nocicepti2.11820089
25MP0002272_abnormal_nervous_system2.09218834
26MP0004134_abnormal_chest_morphology2.03740216
27MP0005360_urolithiasis2.01799153
28MP0002909_abnormal_adrenal_gland1.96153479
29MP0003183_abnormal_peptide_metabolism1.95740368
30MP0002736_abnormal_nociception_after1.94548193
31MP0006054_spinal_hemorrhage1.93704123
32MP0002735_abnormal_chemical_nociception1.87586776
33MP0005275_abnormal_skin_tensile1.86862350
34MP0004510_myositis1.86681936
35MP0001440_abnormal_grooming_behavior1.83529164
36MP0003303_peritoneal_inflammation1.81062460
37MP0005551_abnormal_eye_electrophysiolog1.80262404
38MP0002067_abnormal_sensory_capabilities1.78907296
39MP0008569_lethality_at_weaning1.76408456
40MP0003656_abnormal_erythrocyte_physiolo1.74195439
41MP0005174_abnormal_tail_pigmentation1.68934460
42MP0002396_abnormal_hematopoietic_system1.67925484
43MP0001970_abnormal_pain_threshold1.67910812
44MP0002733_abnormal_thermal_nociception1.63013977
45MP0003329_amyloid_beta_deposits1.62812313
46MP0004858_abnormal_nervous_system1.61794779
47MP0005646_abnormal_pituitary_gland1.61724009
48MP0004811_abnormal_neuron_physiology1.60675066
49MP0004808_abnormal_hematopoietic_stem1.60286099
50MP0001502_abnormal_circadian_rhythm1.53518693
51MP0002166_altered_tumor_susceptibility1.52913610
52MP0002822_catalepsy1.51614944
53MP0005386_behavior/neurological_phenoty1.49914371
54MP0004924_abnormal_behavior1.49914371
55MP0008961_abnormal_basal_metabolism1.49633357
56MP0003879_abnormal_hair_cell1.48849803
57MP0010678_abnormal_skin_adnexa1.45816430
58MP0010386_abnormal_urinary_bladder1.45674659
59MP0000015_abnormal_ear_pigmentation1.43034431
60MP0003633_abnormal_nervous_system1.40564580
61MP0002184_abnormal_innervation1.40003722
62MP0002557_abnormal_social/conspecific_i1.39078186
63MP0000604_amyloidosis1.38786543
64MP0001984_abnormal_olfaction1.27409514
65MP0003724_increased_susceptibility_to1.27280751
66MP0003300_gastrointestinal_ulcer1.26755364
67MP0005409_darkened_coat_color1.26109003
68MP0001188_hyperpigmentation1.24674381
69MP0005397_hematopoietic_system_phenotyp1.22202040
70MP0001545_abnormal_hematopoietic_system1.22202040
71MP0002882_abnormal_neuron_morphology1.21012826
72MP0002229_neurodegeneration1.20869275
73MP0000778_abnormal_nervous_system1.14822638
74MP0002066_abnormal_motor_capabilities/c1.11444543
75MP0002090_abnormal_vision1.11093191
76MP0003075_altered_response_to1.10489351
77MP0005058_abnormal_lysosome_morphology1.09893561
78MP0003091_abnormal_cell_migration1.08736284
79MP0000955_abnormal_spinal_cord1.07767464
80MP0003631_nervous_system_phenotype1.06890757
81MP0001958_emphysema1.05727172
82MP0003950_abnormal_plasma_membrane1.04535239
83MP0005310_abnormal_salivary_gland1.03483331
84MP0010234_abnormal_vibrissa_follicle1.01892922
85MP0000427_abnormal_hair_cycle0.99045575
86MP0001944_abnormal_pancreas_morphology0.97687545
87MP0003045_fibrosis0.96465228
88MP0000465_gastrointestinal_hemorrhage0.96150701
89MP0008874_decreased_physiological_sensi0.95860154
90MP0000371_diluted_coat_color0.93754500
91MP0003828_pulmonary_edema0.93665508
92MP0004885_abnormal_endolymph0.92896639
93MP0004883_abnormal_blood_vessel0.92237455
94MP0001756_abnormal_urination0.90080075
95MP0005503_abnormal_tendon_morphology0.88020312
96MP0002152_abnormal_brain_morphology0.87418605
97MP0002006_tumorigenesis0.86969304
98MP0008004_abnormal_stomach_pH0.86823630
99MP0004484_altered_response_of0.85247356
100MP0006276_abnormal_autonomic_nervous0.85062574
101MP0000538_abnormal_urinary_bladder0.84746552
102MP0002168_other_aberrant_phenotype0.84679061
103MP0005645_abnormal_hypothalamus_physiol0.84415362
104MP0005171_absent_coat_pigmentation0.83147252
105MP0003868_abnormal_feces_composition0.81523651
106MP0000003_abnormal_adipose_tissue0.80111369
107MP0006072_abnormal_retinal_apoptosis0.79669262
108MP0002078_abnormal_glucose_homeostasis0.79260292
109MP0003690_abnormal_glial_cell0.78267013
110MP0002877_abnormal_melanocyte_morpholog0.78170921
111MP0003634_abnormal_glial_cell0.78100655
112MP0002971_abnormal_brown_adipose0.77102148
113MP0004036_abnormal_muscle_relaxation0.76598061
114MP0005167_abnormal_blood-brain_barrier0.76215658
115MP0005535_abnormal_body_temperature0.75083047
116MP0000383_abnormal_hair_follicle0.74078904
117MP0002069_abnormal_eating/drinking_beha0.73139958
118MP0003279_aneurysm0.72533844
119MP0004742_abnormal_vestibular_system0.71770479
120MP0002638_abnormal_pupillary_reflex0.71289581
121MP0005164_abnormal_response_to0.71161704
122MP0003632_abnormal_nervous_system0.70685574
123MP0005253_abnormal_eye_physiology0.69452740
124MP0001851_eye_inflammation0.68814094
125MP0001661_extended_life_span0.67266142
126MP0005379_endocrine/exocrine_gland_phen0.66478371
127MP0005464_abnormal_platelet_physiology0.65521294
128MP0004145_abnormal_muscle_electrophysio0.64977893
129MP0004085_abnormal_heartbeat0.61752176
130MP0002837_dystrophic_cardiac_calcinosis0.60931537
131MP0001664_abnormal_digestion0.60548997
132MP0000920_abnormal_myelination0.54360847
133MP0004233_abnormal_muscle_weight0.54208618
134MP0004130_abnormal_muscle_cell0.53132319
135MP0010307_abnormal_tumor_latency0.52850882
136MP0005166_decreased_susceptibility_to0.52550269
137MP0002928_abnormal_bile_duct0.52243510
138MP0001963_abnormal_hearing_physiology0.52157828
139MP0005195_abnormal_posterior_eye0.51842696
140MP0008872_abnormal_physiological_respon0.51681766
141MP0002095_abnormal_skin_pigmentation0.50140505
142MP0002752_abnormal_somatic_nervous0.49955686
143MP0001905_abnormal_dopamine_level0.49028996
144MP0001765_abnormal_ion_homeostasis0.48661577
145MP0005187_abnormal_penis_morphology0.48649641
146MP0002693_abnormal_pancreas_physiology0.48485443

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.14430240
2Focal seizures (HP:0007359)4.81747605
3Visual hallucinations (HP:0002367)4.53249870
4Epileptic encephalopathy (HP:0200134)3.96484705
5Febrile seizures (HP:0002373)3.95944396
6Progressive cerebellar ataxia (HP:0002073)3.88840263
7Myokymia (HP:0002411)3.77764130
8Absence seizures (HP:0002121)3.64131824
9Papilledema (HP:0001085)3.61024357
10Atonic seizures (HP:0010819)3.60206739
11Genetic anticipation (HP:0003743)3.38637722
12Supranuclear gaze palsy (HP:0000605)3.34223297
13Dialeptic seizures (HP:0011146)3.29959118
14Papillary thyroid carcinoma (HP:0002895)3.17500053
15Action tremor (HP:0002345)3.16650610
16Generalized tonic-clonic seizures (HP:0002069)3.07012190
17Gaze-evoked nystagmus (HP:0000640)3.05526169
18Truncal ataxia (HP:0002078)3.02635902
19Drooling (HP:0002307)3.02211356
20Excessive salivation (HP:0003781)3.02211356
21Impaired smooth pursuit (HP:0007772)3.01751083
22Urinary bladder sphincter dysfunction (HP:0002839)3.00672370
23Hematochezia (HP:0002573)2.98532604
24Acute myeloid leukemia (HP:0004808)2.90491600
25Broad-based gait (HP:0002136)2.85286607
26Inappropriate behavior (HP:0000719)2.84946038
27Postural instability (HP:0002172)2.81685808
28Menstrual irregularities (HP:0000858)2.78378442
29Dysmetric saccades (HP:0000641)2.78141807
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76086664
31Thyroid carcinoma (HP:0002890)2.73122692
32Mutism (HP:0002300)2.73065107
33Diplopia (HP:0000651)2.71909019
34Abnormality of binocular vision (HP:0011514)2.71909019
35Relative macrocephaly (HP:0004482)2.69932254
36Testicular neoplasm (HP:0010788)2.69220758
37Abnormality of ocular smooth pursuit (HP:0000617)2.67951627
38Dysdiadochokinesis (HP:0002075)2.63924556
39Absent frontal sinuses (HP:0002688)2.62051726
40Dysmetria (HP:0001310)2.60605580
41Absent speech (HP:0001344)2.60588292
42Macroorchidism (HP:0000053)2.56855599
43Impaired vibration sensation in the lower limbs (HP:0002166)2.54988721
44Depression (HP:0000716)2.54076598
45Overgrowth (HP:0001548)2.53919313
46Prolonged bleeding time (HP:0003010)2.53863671
47Widely spaced teeth (HP:0000687)2.49376993
48Mitral stenosis (HP:0001718)2.48878653
49Ventricular fibrillation (HP:0001663)2.47635564
50Abnormal social behavior (HP:0012433)2.47588068
51Impaired social interactions (HP:0000735)2.47588068
52Central scotoma (HP:0000603)2.46694488
53Poor eye contact (HP:0000817)2.45078825
54Episodic fever (HP:0001954)2.41138455
55Congenital stationary night blindness (HP:0007642)2.40592210
56Hamartoma of the eye (HP:0010568)2.39454701
57Pheochromocytoma (HP:0002666)2.37861934
58Neuronal loss in central nervous system (HP:0002529)2.36662369
59Protruding tongue (HP:0010808)2.36477873
60Abnormality of macular pigmentation (HP:0008002)2.35211888
61Hyperventilation (HP:0002883)2.32673223
62Stereotypic behavior (HP:0000733)2.32082793
63Cerebral inclusion bodies (HP:0100314)2.30789535
64Hemiplegia (HP:0002301)2.30263822
65Hyperthyroidism (HP:0000836)2.28010127
66Increased cerebral lipofuscin (HP:0011813)2.27602574
67Enlarged penis (HP:0000040)2.25421223
68Scanning speech (HP:0002168)2.21401664
69Global brain atrophy (HP:0002283)2.20227029
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.18388065
71Curly hair (HP:0002212)2.16813883
72Orthostatic hypotension (HP:0001278)2.16413827
73Gingival bleeding (HP:0000225)2.14883915
74Aortic aneurysm (HP:0004942)2.12313030
75Amblyopia (HP:0000646)2.12216394
76Short chin (HP:0000331)2.11283314
77Conjunctival hamartoma (HP:0100780)2.09318240
78Progressive inability to walk (HP:0002505)2.06503971
79Urinary urgency (HP:0000012)2.06421535
80Epileptiform EEG discharges (HP:0011182)2.05335296
81Spontaneous hematomas (HP:0007420)2.04991441
82Volvulus (HP:0002580)2.03428038
83Neurofibrillary tangles (HP:0002185)2.03325044
84Bradykinesia (HP:0002067)2.02055756
85Anxiety (HP:0000739)2.00939319
86Apathy (HP:0000741)2.00846585
87Abnormality of salivation (HP:0100755)2.00711114
88Abnormal eating behavior (HP:0100738)2.00119879
89Insidious onset (HP:0003587)1.98981087
90Termporal pattern (HP:0011008)1.98981087
91Hypothermia (HP:0002045)1.98845997
92Hypoglycemic seizures (HP:0002173)1.98788512
93Agitation (HP:0000713)1.98646309
94Asymmetry of the thorax (HP:0001555)1.96238527
95Ankle clonus (HP:0011448)1.95720125
96Lower limb amyotrophy (HP:0007210)1.94362450
97Polycythemia (HP:0001901)1.94066970
98Hemiparesis (HP:0001269)1.93422234
99Resting tremor (HP:0002322)1.93155163
100Blue irides (HP:0000635)1.92232612
101Fair hair (HP:0002286)1.90923467
102Pointed chin (HP:0000307)1.90511565
103Generalized hypopigmentation of hair (HP:0011358)1.89563084
104Increased CSF protein (HP:0002922)1.89302262
105EEG with generalized epileptiform discharges (HP:0011198)1.88888330
106Degeneration of the lateral corticospinal tracts (HP:0002314)1.88226943
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.88226943
108Hypoglycemic coma (HP:0001325)1.87551387
109Subacute progressive viral hepatitis (HP:0006572)1.86552178
110Disinhibition (HP:0000734)1.86342676
111Intention tremor (HP:0002080)1.86172352
112Open mouth (HP:0000194)1.84662579
113Impaired vibratory sensation (HP:0002495)1.84359337
114Abnormality of the corticospinal tract (HP:0002492)1.84348040
115Spastic gait (HP:0002064)1.83975271
116Psychosis (HP:0000709)1.82796030
117Ocular albinism (HP:0001107)1.81809211
118Peritonitis (HP:0002586)1.81543534
119Diminished motivation (HP:0000745)1.79591171
120Aqueductal stenosis (HP:0002410)1.78552131
121Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77265376
122Truncal obesity (HP:0001956)1.77261881
123Hyperinsulinemic hypoglycemia (HP:0000825)1.76232380
124Insulin-resistant diabetes mellitus (HP:0000831)1.75934694
125Neuroendocrine neoplasm (HP:0100634)1.73475796
126Acanthocytosis (HP:0001927)1.73422406
127Abnormality of the fingertips (HP:0001211)1.73025716
128Rapidly progressive (HP:0003678)1.72132683
129Hyperglycemia (HP:0003074)1.70978024
130Bradycardia (HP:0001662)1.70278211
131Iris hypopigmentation (HP:0007730)1.70228069
132Urethral obstruction (HP:0000796)1.69648470
133Narrow palate (HP:0000189)1.69525783
134Hypsarrhythmia (HP:0002521)1.68595544
135Ankyloglossia (HP:0010296)1.68595037
136Striae distensae (HP:0001065)1.68216174
137Lower limb asymmetry (HP:0100559)1.67265992
138Generalized myoclonic seizures (HP:0002123)1.66332720
139Slow saccadic eye movements (HP:0000514)1.66326996
140Lower limb muscle weakness (HP:0007340)1.66216345
141Status epilepticus (HP:0002133)1.66096344
142Difficulty running (HP:0009046)1.65592992
143Abnormality of saccadic eye movements (HP:0000570)1.65572073
144Obsessive-compulsive behavior (HP:0000722)1.65167698
145Submucous cleft hard palate (HP:0000176)1.64529357
146Fetal akinesia sequence (HP:0001989)1.64083762
147Dilatation of the ascending aorta (HP:0005111)1.64038629
148Increased neuronal autofluorescent lipopigment (HP:0002074)1.63712431
149Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63253028
150Abnormality of polysaccharide metabolism (HP:0011012)1.63253028
151Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63253028
152Thickened calvaria (HP:0002684)1.63062460
153Sandal gap (HP:0001852)1.62026085
154Tapered finger (HP:0001182)1.61860937
155Poikilocytosis (HP:0004447)1.60993141
156Craniofacial hyperostosis (HP:0004493)1.60144356
157Clonus (HP:0002169)1.59897362
158Cranial hyperostosis (HP:0004437)1.57590615
159Metaphyseal dysplasia (HP:0100255)1.57046172
160Cubitus valgus (HP:0002967)1.56679227
161Neoplasm of the thyroid gland (HP:0100031)1.56408314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.40267450
2RIPK44.01481151
3EPHA43.56545855
4MAP3K93.44642506
5MAP3K42.92938281
6AKT32.54610345
7ACVR1B2.45562198
8KSR22.31194136
9TRPM72.25832177
10MAP2K72.25695266
11DAPK22.21073974
12FES2.12412685
13MAP3K132.07986431
14MINK12.05075779
15PAK62.04033924
16MAP2K41.98770901
17SIK21.97696130
18CAMK1G1.79490257
19MAP3K61.72159676
20CAMKK11.71403001
21MAP3K121.64319357
22PRKD31.53643901
23PIK3CG1.51847008
24TAOK31.51593711
25STK381.50449482
26NTRK21.49392791
27DAPK11.49316541
28FGFR21.45685134
29NTRK11.40521925
30KSR11.40151955
31MAP3K21.37392398
32TAOK11.35372672
33PLK21.35122489
34MARK11.32688314
35BMPR1B1.31496311
36RET1.29222631
37CDK51.28257846
38CAMKK21.28121370
39SGK21.21542426
40SGK31.20797549
41RAF11.19917546
42IRAK11.13636897
43IRAK21.12493731
44TEC1.12032681
45BMPR21.11948528
46NLK1.11830143
47CAMK1D1.09070967
48PNCK1.08996655
49PRKCH1.07508917
50MAP2K31.05460926
51YES11.04716266
52SCYL21.03237758
53MAP3K11.00230564
54PRKG20.99082991
55PINK10.98977706
56SGK10.95315939
57DMPK0.95103416
58PTK2B0.90275761
59PDK10.89846318
60EPHA30.89051672
61ERBB30.89038795
62RIPK10.86913062
63TYK20.86644601
64SGK4940.84246115
65SGK2230.84246115
66GRK50.84122900
67STK110.82306597
68TNIK0.81355269
69FRK0.79801643
70MAP3K70.79530116
71CAMK10.78043150
72MAPK130.78028565
73TNK20.76854129
74PDPK10.76509763
75PKN20.72857376
76HIPK20.72137003
77CCNB10.70870621
78PRKCG0.70237139
79ALK0.67970803
80MAPK100.67747191
81MARK20.67733434
82FGR0.67201133
83CAMK2A0.67168689
84PRPF4B0.65679680
85MAP2K10.63332183
86CSNK1G20.63258356
87MAP3K140.63225402
88PDGFRA0.60986157
89RPS6KB10.60762311
90STK30.60214324
91INSRR0.59400837
92HCK0.58861007
93RPS6KA20.58836553
94BTK0.58108067
95PHKG10.57616590
96PHKG20.57616590
97LATS20.55932054
98JAK10.55416879
99SYK0.54834266
100CDK190.54333177
101FYN0.53849739
102CASK0.51596213
103DYRK1A0.51584982
104PRKAA20.51135521
105TYRO30.49752632
106WNK10.49719210
107RPS6KA30.49032511
108PRKCE0.48675809
109BLK0.47856730
110MAP2K60.47403238
111MAP3K50.46560676
112ZAP700.45742505
113BRSK20.44199335
114ARAF0.43775407
115PDGFRB0.43008262
116FLT30.42561657
117CDK120.41281466
118UHMK10.40910779
119JAK20.40517296
120FGFR30.40410150
121PTK20.40409861
122KIT0.40201745
123EEF2K0.39442546
124CAMK2B0.37966358
125CAMK40.37362457
126GRK60.37045368
127PAK30.36648184
128PRKAA10.35520195
129CDC42BPA0.35494240
130PRKCB0.34960718
131CDK180.34337228
132CDK150.33641461
133PRKCQ0.33471073
134JAK30.33428760
135MAPK120.31416068
136FER0.29872553
137CDK140.29688876
138BRD40.28935659
139PRKD20.28503014

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.85673611
2Long-term potentiation_Homo sapiens_hsa047202.46601271
3Synaptic vesicle cycle_Homo sapiens_hsa047212.35362925
4Circadian entrainment_Homo sapiens_hsa047132.24531087
5Olfactory transduction_Homo sapiens_hsa047402.16829023
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16734719
7Glutamatergic synapse_Homo sapiens_hsa047242.10354827
8Morphine addiction_Homo sapiens_hsa050322.05038818
9Amphetamine addiction_Homo sapiens_hsa050312.02324002
10GABAergic synapse_Homo sapiens_hsa047271.98499182
11Salivary secretion_Homo sapiens_hsa049701.93826270
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81885837
13Dopaminergic synapse_Homo sapiens_hsa047281.77238208
14Insulin secretion_Homo sapiens_hsa049111.74685098
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70895924
16Cholinergic synapse_Homo sapiens_hsa047251.67157414
17Phototransduction_Homo sapiens_hsa047441.66753436
18Renin secretion_Homo sapiens_hsa049241.61981105
19Gastric acid secretion_Homo sapiens_hsa049711.56199351
20Long-term depression_Homo sapiens_hsa047301.52094758
21GnRH signaling pathway_Homo sapiens_hsa049121.49079112
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.48702730
23Type II diabetes mellitus_Homo sapiens_hsa049301.47973659
24Oxytocin signaling pathway_Homo sapiens_hsa049211.47766365
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47738840
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.47476113
27Serotonergic synapse_Homo sapiens_hsa047261.35728761
28Calcium signaling pathway_Homo sapiens_hsa040201.34637081
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34544237
30Taste transduction_Homo sapiens_hsa047421.34542442
31Cocaine addiction_Homo sapiens_hsa050301.33023242
32Glioma_Homo sapiens_hsa052141.31982852
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27035277
34cAMP signaling pathway_Homo sapiens_hsa040241.26830556
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26249978
36Dorso-ventral axis formation_Homo sapiens_hsa043201.20208229
37Estrogen signaling pathway_Homo sapiens_hsa049151.18696521
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14658558
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12611847
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11588748
41Gap junction_Homo sapiens_hsa045401.08538680
42Acute myeloid leukemia_Homo sapiens_hsa052211.07849046
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03550152
44ErbB signaling pathway_Homo sapiens_hsa040121.01102405
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.00665880
46VEGF signaling pathway_Homo sapiens_hsa043701.00345576
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99697850
48mTOR signaling pathway_Homo sapiens_hsa041500.98695571
49Choline metabolism in cancer_Homo sapiens_hsa052310.98461162
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98158413
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.97643828
52Pancreatic secretion_Homo sapiens_hsa049720.96573749
53Collecting duct acid secretion_Homo sapiens_hsa049660.96545498
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95792586
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91895180
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90687050
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86782459
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.86398586
59Inositol phosphate metabolism_Homo sapiens_hsa005620.85882589
60Insulin resistance_Homo sapiens_hsa049310.85545297
61Osteoclast differentiation_Homo sapiens_hsa043800.85104245
62Non-small cell lung cancer_Homo sapiens_hsa052230.84435404
63B cell receptor signaling pathway_Homo sapiens_hsa046620.83379058
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83365340
65MAPK signaling pathway_Homo sapiens_hsa040100.82462080
66Melanogenesis_Homo sapiens_hsa049160.79815197
67Amoebiasis_Homo sapiens_hsa051460.79743087
68Thyroid hormone synthesis_Homo sapiens_hsa049180.79641668
69Focal adhesion_Homo sapiens_hsa045100.78446873
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75278680
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75144489
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.74368423
73Platelet activation_Homo sapiens_hsa046110.73787646
74Chemokine signaling pathway_Homo sapiens_hsa040620.71591604
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71297186
76Fatty acid biosynthesis_Homo sapiens_hsa000610.70741789
77Oocyte meiosis_Homo sapiens_hsa041140.69205101
78Mineral absorption_Homo sapiens_hsa049780.69198560
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65078893
80Axon guidance_Homo sapiens_hsa043600.64337399
81Endometrial cancer_Homo sapiens_hsa052130.64319765
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64276612
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63669153
84Prostate cancer_Homo sapiens_hsa052150.63634865
85Renal cell carcinoma_Homo sapiens_hsa052110.63326057
86Rap1 signaling pathway_Homo sapiens_hsa040150.62812383
87Regulation of autophagy_Homo sapiens_hsa041400.62361492
88Dilated cardiomyopathy_Homo sapiens_hsa054140.61951130
89Circadian rhythm_Homo sapiens_hsa047100.61732970
90Prolactin signaling pathway_Homo sapiens_hsa049170.61519291
91Glucagon signaling pathway_Homo sapiens_hsa049220.61439205
92Ras signaling pathway_Homo sapiens_hsa040140.61352950
93Tuberculosis_Homo sapiens_hsa051520.60234826
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59786868
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58915678
96Melanoma_Homo sapiens_hsa052180.58123750
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.58008638
98Vibrio cholerae infection_Homo sapiens_hsa051100.57867782
99AMPK signaling pathway_Homo sapiens_hsa041520.56873446
100ABC transporters_Homo sapiens_hsa020100.56447977
101Pancreatic cancer_Homo sapiens_hsa052120.56032163
102African trypanosomiasis_Homo sapiens_hsa051430.55734188
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.54876342
104Endocytosis_Homo sapiens_hsa041440.54849554
105T cell receptor signaling pathway_Homo sapiens_hsa046600.54571686
106Insulin signaling pathway_Homo sapiens_hsa049100.52904954
107Chronic myeloid leukemia_Homo sapiens_hsa052200.51669095
108Protein digestion and absorption_Homo sapiens_hsa049740.51057014
109Lysosome_Homo sapiens_hsa041420.50799016
110Proteoglycans in cancer_Homo sapiens_hsa052050.49885100
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.49850044
112Sphingolipid metabolism_Homo sapiens_hsa006000.49433733
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49339244
114HIF-1 signaling pathway_Homo sapiens_hsa040660.48744385
115Colorectal cancer_Homo sapiens_hsa052100.45697751
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45144974
117Ovarian steroidogenesis_Homo sapiens_hsa049130.43578818
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42189408
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41813598
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39216203
121FoxO signaling pathway_Homo sapiens_hsa040680.38976571

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