STXBP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: STXBP6 binds components of the SNARE complex (see MIM 603215) and may be involved in regulating SNARE complex formation (Scales et al., 2002 [PubMed 12145319]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.10842649
2ensheathment of neurons (GO:0007272)6.56004165
3axon ensheathment (GO:0008366)6.56004165
4myelination (GO:0042552)6.49308483
5long-chain fatty acid biosynthetic process (GO:0042759)5.79383674
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.74789468
7glutamate secretion (GO:0014047)5.09099038
8synaptic vesicle maturation (GO:0016188)4.99430236
9myelin maintenance (GO:0043217)4.96520818
10negative regulation of neurotransmitter secretion (GO:0046929)4.84142289
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.80979119
12proline transport (GO:0015824)4.78920272
13negative regulation of neurotransmitter transport (GO:0051589)4.65293264
14glycerophospholipid catabolic process (GO:0046475)4.51308643
15oligodendrocyte differentiation (GO:0048709)4.49149103
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.39706944
17presynaptic membrane organization (GO:0097090)4.35552679
18cholesterol biosynthetic process (GO:0006695)4.32677305
19apical protein localization (GO:0045176)4.29483079
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.28677197
21asymmetric protein localization (GO:0008105)4.26256927
22cellular sodium ion homeostasis (GO:0006883)4.26174885
23presynaptic membrane assembly (GO:0097105)4.25481055
24negative regulation of protein localization to cell surface (GO:2000009)4.24981636
25photoreceptor cell differentiation (GO:0046530)4.13632237
26eye photoreceptor cell differentiation (GO:0001754)4.13632237
27cellular potassium ion homeostasis (GO:0030007)4.09473376
28establishment of mitochondrion localization (GO:0051654)4.08264827
29regulation of collateral sprouting (GO:0048670)4.06183764
30synaptic vesicle exocytosis (GO:0016079)4.03375119
31positive regulation of oligodendrocyte differentiation (GO:0048714)3.97643105
32response to methylmercury (GO:0051597)3.97597286
33regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.95525858
34astrocyte development (GO:0014002)3.84459854
35neurotransmitter secretion (GO:0007269)3.82467654
36inositol phosphate catabolic process (GO:0071545)3.78322930
37sterol biosynthetic process (GO:0016126)3.74924342
38creatine metabolic process (GO:0006600)3.74632886
39L-amino acid import (GO:0043092)3.73201060
40peptidyl-tyrosine autophosphorylation (GO:0038083)3.70126759
41isoprenoid biosynthetic process (GO:0008299)3.69605363
42regulation of synaptic vesicle exocytosis (GO:2000300)3.68312581
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67653084
44limb bud formation (GO:0060174)3.67100694
45inositol phosphate dephosphorylation (GO:0046855)3.64974905
46phosphorylated carbohydrate dephosphorylation (GO:0046838)3.64974905
47sodium ion export (GO:0071436)3.61134362
48import into cell (GO:0098657)3.58846359
49negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.54235789
50protein-chromophore linkage (GO:0018298)3.49124325
51substantia nigra development (GO:0021762)3.48049515
52neuron cell-cell adhesion (GO:0007158)3.46816134
53positive regulation of action potential (GO:0045760)3.43912378
54cerebral cortex radially oriented cell migration (GO:0021799)3.43163204
55long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.39100615
56serotonin metabolic process (GO:0042428)3.37663553
57potassium ion homeostasis (GO:0055075)3.34349356
58neuron remodeling (GO:0016322)3.32907602
59regulation of synaptic vesicle transport (GO:1902803)3.32354104
60protein palmitoylation (GO:0018345)3.31436784
61alanine transport (GO:0032328)3.30313025
62regulation of neuronal synaptic plasticity (GO:0048168)3.28781918
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28462169
64peripheral nervous system axon ensheathment (GO:0032292)3.28256432
65myelination in peripheral nervous system (GO:0022011)3.28256432
66amyloid precursor protein metabolic process (GO:0042982)3.26536472
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26495827
68neurotransmitter transport (GO:0006836)3.26108693
69response to redox state (GO:0051775)3.24907514
70neuronal action potential propagation (GO:0019227)3.22201803
71long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.18198364
72synaptic transmission, glutamatergic (GO:0035249)3.17308528
73detection of calcium ion (GO:0005513)3.15165562
74response to lipoprotein particle (GO:0055094)3.14928824
75primary amino compound metabolic process (GO:1901160)3.14444492
76adult walking behavior (GO:0007628)3.11746624
77cell communication involved in cardiac conduction (GO:0086065)3.04805704
78magnesium ion transport (GO:0015693)3.04786375
79ionotropic glutamate receptor signaling pathway (GO:0035235)3.04751583
80exploration behavior (GO:0035640)3.04456032
81protein localization to synapse (GO:0035418)3.03448253
82transmission of nerve impulse (GO:0019226)3.03017281
83axon development (GO:0061564)3.02751145
84regulation of lipoprotein metabolic process (GO:0050746)3.02078803
85positive regulation of synapse maturation (GO:0090129)3.01407786
86locomotory exploration behavior (GO:0035641)3.00868145
87positive regulation of membrane potential (GO:0045838)3.00590536
88negative regulation of axonogenesis (GO:0050771)3.00238513
89organ growth (GO:0035265)2.99199463
90righting reflex (GO:0060013)2.98893358
91potassium ion import (GO:0010107)2.98378585
92negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93790228
93negative regulation of dendrite morphogenesis (GO:0050774)2.93232805
94neuron-neuron synaptic transmission (GO:0007270)2.92645204
95neurotransmitter-gated ion channel clustering (GO:0072578)2.91534665
96negative regulation of execution phase of apoptosis (GO:1900118)2.90879408
97vocalization behavior (GO:0071625)2.90436269
98fatty-acyl-CoA biosynthetic process (GO:0046949)2.90397840
99nucleotide transmembrane transport (GO:1901679)2.90353932
100sodium ion homeostasis (GO:0055078)2.90310547
101regulation of neurotransmitter levels (GO:0001505)2.88361399
102glutamate receptor signaling pathway (GO:0007215)2.85123009
103virion attachment to host cell (GO:0019062)2.84488113
104adhesion of symbiont to host cell (GO:0044650)2.84488113
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83382069
106regulation of Rac protein signal transduction (GO:0035020)2.81055265
107cell communication by electrical coupling (GO:0010644)2.80860860
108amino acid import (GO:0043090)2.80447551
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78997369
110neuronal ion channel clustering (GO:0045161)2.78653037
111cellular response to epinephrine stimulus (GO:0071872)2.78534640
112regulation of sodium ion transmembrane transporter activity (GO:2000649)2.78286558
113auditory behavior (GO:0031223)2.77963295
114positive regulation of cellular amine metabolic process (GO:0033240)2.77717266
115membrane depolarization during action potential (GO:0086010)2.77568558
116gamma-aminobutyric acid transport (GO:0015812)2.76577252
117GPI anchor biosynthetic process (GO:0006506)2.74587085
118negative regulation of axon extension (GO:0030517)2.74438994
119membrane tubulation (GO:0097320)2.74367099
120very long-chain fatty acid metabolic process (GO:0000038)2.73209843
121GPI anchor metabolic process (GO:0006505)2.73120240
122C4-dicarboxylate transport (GO:0015740)2.72904686
123fatty-acyl-CoA metabolic process (GO:0035337)2.72860334
124regulation of synapse maturation (GO:0090128)2.72032546
125receptor recycling (GO:0001881)2.70889835
126negative regulation of hormone biosynthetic process (GO:0032353)2.69432712
127regulation of somitogenesis (GO:0014807)2.68661720
128positive regulation of glial cell differentiation (GO:0045687)2.68131736
129regulation of voltage-gated calcium channel activity (GO:1901385)2.65888384
130inositol metabolic process (GO:0006020)2.64322912
131regulation of sodium ion transmembrane transport (GO:1902305)2.64008173
132negative regulation of JUN kinase activity (GO:0043508)2.63854373
133regulation of neurotransmitter secretion (GO:0046928)2.63521264
134postsynaptic membrane organization (GO:0001941)2.62623379
135membrane assembly (GO:0071709)2.62561251
136polyol catabolic process (GO:0046174)2.62004395
137lateral sprouting from an epithelium (GO:0060601)2.61868510
138regulation of dendritic spine morphogenesis (GO:0061001)2.58243016
139nerve growth factor signaling pathway (GO:0038180)2.57318913
140cardiac conduction (GO:0061337)2.57211402
141peptidyl-cysteine modification (GO:0018198)2.56488396
142histone H2B ubiquitination (GO:0033523)2.56101364
143leukocyte migration involved in inflammatory response (GO:0002523)2.55879421
144neuron recognition (GO:0008038)2.55584130
145regulation of membrane repolarization (GO:0060306)2.55424590
146glial cell development (GO:0021782)2.55415461
147regulation of heart rate by cardiac conduction (GO:0086091)2.55018773
148peripheral nervous system development (GO:0007422)2.54896913
149vitamin transmembrane transport (GO:0035461)2.54875104
150regulation of glutamate receptor signaling pathway (GO:1900449)2.53996570
151regulation of synaptic plasticity (GO:0048167)2.53023661
152glial cell differentiation (GO:0010001)2.52853800
153regulation of neurotransmitter transport (GO:0051588)2.52689918
154positive regulation of sodium ion transport (GO:0010765)2.52436945
155calcium ion-dependent exocytosis (GO:0017156)2.51356168
156regulation of cell communication by electrical coupling (GO:0010649)2.51240806
157positive regulation of dendritic spine development (GO:0060999)2.50638067
158transepithelial transport (GO:0070633)2.50424668
159enteric nervous system development (GO:0048484)2.48858580
160regulation of dendritic spine development (GO:0060998)2.47735826
161response to epinephrine (GO:0071871)2.47605385
162long-term synaptic potentiation (GO:0060291)2.47337236
163atrial cardiac muscle cell action potential (GO:0086014)2.47301557
164negative regulation of hormone metabolic process (GO:0032351)2.47230868
165glycosylceramide metabolic process (GO:0006677)2.46957176
166response to dietary excess (GO:0002021)2.45992454
167preassembly of GPI anchor in ER membrane (GO:0016254)2.45298560
168neural nucleus development (GO:0048857)2.45198522
169regulation of catecholamine metabolic process (GO:0042069)2.44901217
170regulation of dopamine metabolic process (GO:0042053)2.44901217
171positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.44560092
172gamma-aminobutyric acid signaling pathway (GO:0007214)2.42726888
173neurotransmitter uptake (GO:0001504)2.42381721
174regulation of calcium ion-dependent exocytosis (GO:0017158)2.41682850
175behavioral defense response (GO:0002209)2.41406787
176behavioral fear response (GO:0001662)2.41406787
177positive regulation of gliogenesis (GO:0014015)2.41048661
178positive regulation of neurotransmitter transport (GO:0051590)2.40972271
179regulation of bile acid biosynthetic process (GO:0070857)2.39946770
180intestinal cholesterol absorption (GO:0030299)2.39899757
181cellular response to monoamine stimulus (GO:0071868)2.38194569
182cellular response to catecholamine stimulus (GO:0071870)2.38194569
183microtubule polymerization or depolymerization (GO:0031109)2.37550757
184negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37377234
185cranial nerve development (GO:0021545)2.36196918
186Leydig cell differentiation (GO:0033327)2.35208733
187short-term memory (GO:0007614)2.34792653
188axon ensheathment in central nervous system (GO:0032291)10.9003018
189central nervous system myelination (GO:0022010)10.9003018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.42438647
2EZH2_22144423_ChIP-Seq_EOC_Human3.21357672
3TAF15_26573619_Chip-Seq_HEK293_Human2.56908480
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51794416
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50090506
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46978332
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.31813221
8* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.24942005
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19892575
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19247086
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19247086
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.12818666
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11379582
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06306009
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04410549
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02968773
17* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01701765
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98357016
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96586298
20* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91775199
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91067588
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90985046
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90231291
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89015571
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.83142453
26AR_21572438_ChIP-Seq_LNCaP_Human1.81403239
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77936344
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.73340800
29VDR_22108803_ChIP-Seq_LS180_Human1.71139429
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67953166
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67705945
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67554655
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67232182
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64820796
35ER_23166858_ChIP-Seq_MCF-7_Human1.63867871
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.62933853
37* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62904887
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61791417
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.58572909
40* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57835037
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52565663
42DROSHA_22980978_ChIP-Seq_HELA_Human1.48473972
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48182412
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47185469
45IGF1R_20145208_ChIP-Seq_DFB_Human1.44939333
46P300_19829295_ChIP-Seq_ESCs_Human1.44790282
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.44753820
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42688341
49AR_25329375_ChIP-Seq_VCAP_Human1.40405162
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35605570
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33813809
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30583215
53* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30226303
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29064571
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28614038
56* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27816929
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.27588223
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27458772
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26893198
60* FUS_26573619_Chip-Seq_HEK293_Human1.22860941
61* RNF2_27304074_Chip-Seq_NSC_Mouse1.21516191
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.20699194
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16697843
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.16660959
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16499375
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14774983
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14774983
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14719733
69SMAD4_21799915_ChIP-Seq_A2780_Human1.14565453
70* REST_21632747_ChIP-Seq_MESCs_Mouse1.14539593
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14358446
72* AR_19668381_ChIP-Seq_PC3_Human1.13703469
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12893000
74* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12661733
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12418871
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12383634
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12245762
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11938088
79* STAT3_23295773_ChIP-Seq_U87_Human1.11935841
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.11585792
81LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10777185
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09836012
83BCAT_22108803_ChIP-Seq_LS180_Human1.09352070
84P300_18555785_Chip-Seq_ESCs_Mouse1.09110902
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08684475
86TCF4_22108803_ChIP-Seq_LS180_Human1.08386131
87JUN_21703547_ChIP-Seq_K562_Human1.08065281
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.07518697
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06300558
90* FOXA2_19822575_ChIP-Seq_HepG2_Human1.05018922
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.04929474
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04886800
93NANOG_19829295_ChIP-Seq_ESCs_Human1.04338277
94SOX2_19829295_ChIP-Seq_ESCs_Human1.04338277
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04106327
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03900532
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03900532
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03259162
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.03101619
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01987380
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01675309
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01240519
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.00788486
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.00731381
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.00574988
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00520943
107AHR_22903824_ChIP-Seq_MCF-7_Human1.00176865
108* TCF4_23295773_ChIP-Seq_U87_Human1.00077763
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99485913
110P53_22387025_ChIP-Seq_ESCs_Mouse0.98917788
111* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97901072
112E2F1_18555785_Chip-Seq_ESCs_Mouse0.97710211
113POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97442733
114* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96615437
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96582262
116SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95591759
117* EP300_21415370_ChIP-Seq_HL-1_Mouse0.95552559
118HTT_18923047_ChIP-ChIP_STHdh_Human0.95459335
119TP53_18474530_ChIP-ChIP_U2OS_Human0.95350936
120* ARNT_22903824_ChIP-Seq_MCF-7_Human0.94278465
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93865630
122EZH2_27294783_Chip-Seq_NPCs_Mouse0.93750898
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.93459410
124TP53_16413492_ChIP-PET_HCT116_Human0.93398269
125* RUNX2_22187159_ChIP-Seq_PCA_Human0.93313374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.89293704
2MP0003880_abnormal_central_pattern4.20009119
3MP0004270_analgesia3.43996136
4MP0002638_abnormal_pupillary_reflex3.21234734
5MP0003136_yellow_coat_color3.10991587
6MP0009780_abnormal_chondrocyte_physiolo3.07714294
7MP0003950_abnormal_plasma_membrane2.92182157
8MP0004742_abnormal_vestibular_system2.83604344
9MP0003690_abnormal_glial_cell2.77938625
10MP0003011_delayed_dark_adaptation2.77139481
11MP0003122_maternal_imprinting2.70741325
12MP0004885_abnormal_endolymph2.68077442
13MP0005171_absent_coat_pigmentation2.65379861
14MP0001486_abnormal_startle_reflex2.60151977
15MP0002272_abnormal_nervous_system2.48288816
16MP0005085_abnormal_gallbladder_physiolo2.47914685
17MP0005409_darkened_coat_color2.40098360
18MP0004859_abnormal_synaptic_plasticity2.38536121
19MP0001529_abnormal_vocalization2.37430461
20MP0001905_abnormal_dopamine_level2.35779547
21MP0005365_abnormal_bile_salt2.31610740
22MP0001485_abnormal_pinna_reflex2.29725523
23MP0003329_amyloid_beta_deposits2.23851399
24MP0002064_seizures2.21578196
25MP0000778_abnormal_nervous_system2.16004954
26MP0005083_abnormal_biliary_tract2.11579440
27MP0003634_abnormal_glial_cell2.07200088
28MP0004142_abnormal_muscle_tone2.03038246
29MP0004381_abnormal_hair_follicle2.02228311
30MP0005084_abnormal_gallbladder_morpholo2.02212589
31MP0003635_abnormal_synaptic_transmissio1.87312806
32MP0009745_abnormal_behavioral_response1.86359838
33MP0009046_muscle_twitch1.85569199
34MP0005423_abnormal_somatic_nervous1.82584223
35MP0002229_neurodegeneration1.81248066
36MP0002734_abnormal_mechanical_nocicepti1.80720061
37MP0002909_abnormal_adrenal_gland1.78710159
38MP0000462_abnormal_digestive_system1.73866799
39MP0010386_abnormal_urinary_bladder1.72134705
40MP0000566_synostosis1.68535777
41MP0005410_abnormal_fertilization1.67193991
42MP0005451_abnormal_body_composition1.65368634
43MP0002837_dystrophic_cardiac_calcinosis1.63517375
44MP0003879_abnormal_hair_cell1.59389652
45MP0010678_abnormal_skin_adnexa1.58577399
46MP0003632_abnormal_nervous_system1.56318486
47MP0001440_abnormal_grooming_behavior1.55715340
48MP0000383_abnormal_hair_follicle1.52901663
49MP0008877_abnormal_DNA_methylation1.51968401
50MP0005551_abnormal_eye_electrophysiolog1.51168634
51MP0008260_abnormal_autophagy1.49219716
52MP0002572_abnormal_emotion/affect_behav1.46285177
53MP0001963_abnormal_hearing_physiology1.45743929
54MP0000955_abnormal_spinal_cord1.40521326
55MP0002882_abnormal_neuron_morphology1.40152188
56MP0004215_abnormal_myocardial_fiber1.38300563
57MP0001346_abnormal_lacrimal_gland1.37391015
58MP0003787_abnormal_imprinting1.34427513
59MP0002063_abnormal_learning/memory/cond1.34257647
60MP0004043_abnormal_pH_regulation1.33431282
61MP0003868_abnormal_feces_composition1.33244920
62MP0002067_abnormal_sensory_capabilities1.32516824
63MP0004134_abnormal_chest_morphology1.28717015
64MP0005379_endocrine/exocrine_gland_phen1.27446013
65MP0002752_abnormal_somatic_nervous1.25982925
66MP0001666_abnormal_nutrient_absorption1.24473815
67MP0001970_abnormal_pain_threshold1.22252560
68MP0002876_abnormal_thyroid_physiology1.21440223
69MP0003631_nervous_system_phenotype1.20830516
70MP0002066_abnormal_motor_capabilities/c1.20404777
71MP0008569_lethality_at_weaning1.20030740
72MP0003938_abnormal_ear_development1.18545016
73MP0000762_abnormal_tongue_morphology1.17880868
74MP0000026_abnormal_inner_ear1.16926050
75MP0002139_abnormal_hepatobiliary_system1.15708960
76MP0001299_abnormal_eye_distance/1.14869962
77MP0001984_abnormal_olfaction1.14625565
78MP0001968_abnormal_touch/_nociception1.10948839
79MP0002735_abnormal_chemical_nociception1.10175027
80MP0003121_genomic_imprinting1.08613894
81MP0005360_urolithiasis1.08487288
82MP0004924_abnormal_behavior1.06956442
83MP0005386_behavior/neurological_phenoty1.06956442
84MP0003937_abnormal_limbs/digits/tail_de1.04628065
85MP0001661_extended_life_span1.03950199
86MP0003633_abnormal_nervous_system1.03119105
87MP0003195_calcinosis1.00469256
88MP0000604_amyloidosis1.00047962
89MP0002733_abnormal_thermal_nociception0.99708254
90MP0004019_abnormal_vitamin_homeostasis0.99326323
91MP0005195_abnormal_posterior_eye0.98740718
92MP0001986_abnormal_taste_sensitivity0.98032721
93MP0010234_abnormal_vibrissa_follicle0.96087525
94MP0002102_abnormal_ear_morphology0.95710961
95MP0002928_abnormal_bile_duct0.93070019
96MP0000647_abnormal_sebaceous_gland0.92734736
97MP0003123_paternal_imprinting0.92690038
98MP0004811_abnormal_neuron_physiology0.91572292
99MP0001188_hyperpigmentation0.91066248
100MP0003718_maternal_effect0.89573315
101MP0000579_abnormal_nail_morphology0.89128920
102MP0001501_abnormal_sleep_pattern0.88514751
103MP0001764_abnormal_homeostasis0.86579243
104MP0002184_abnormal_innervation0.86126332
105MP0000467_abnormal_esophagus_morphology0.85921614
106MP0010329_abnormal_lipoprotein_level0.85707243
107MP0004145_abnormal_muscle_electrophysio0.85622280
108MP0002152_abnormal_brain_morphology0.84703567
109MP0000747_muscle_weakness0.84591316
110MP0006072_abnormal_retinal_apoptosis0.84454589
111MP0002557_abnormal_social/conspecific_i0.83623691
112MP0004147_increased_porphyrin_level0.83036134
113MP0005623_abnormal_meninges_morphology0.81917781
114MP0005253_abnormal_eye_physiology0.80199072
115MP0002736_abnormal_nociception_after0.79942639
116MP0001851_eye_inflammation0.79708412
117MP0002090_abnormal_vision0.79286448
118MP0009250_abnormal_appendicular_skeleto0.79166582
119MP0005645_abnormal_hypothalamus_physiol0.77064958
120MP0004133_heterotaxia0.76227428
121MP0001756_abnormal_urination0.74770164
122MP0000631_abnormal_neuroendocrine_gland0.74685939
123MP0004085_abnormal_heartbeat0.74604170
124MP0001177_atelectasis0.72988160
125MP0003252_abnormal_bile_duct0.72829385
126MP0001765_abnormal_ion_homeostasis0.70066828
127MP0000013_abnormal_adipose_tissue0.69649854
128MP0002234_abnormal_pharynx_morphology0.69193653
129MP0002160_abnormal_reproductive_system0.69069815
130MP0001502_abnormal_circadian_rhythm0.68018807
131MP0000639_abnormal_adrenal_gland0.67273078
132MP0005646_abnormal_pituitary_gland0.66815880
133MP0002295_abnormal_pulmonary_circulatio0.66039476
134MP0001340_abnormal_eyelid_morphology0.65997490
135MP0006276_abnormal_autonomic_nervous0.65814463
136MP0002069_abnormal_eating/drinking_beha0.65665371
137MP0001348_abnormal_lacrimal_gland0.64478752
138MP0005167_abnormal_blood-brain_barrier0.64416893
139MP0005408_hypopigmentation0.63986627
140MP0001664_abnormal_digestion0.63625086
141MP0000613_abnormal_salivary_gland0.61580029
142MP0002938_white_spotting0.61230021
143MP0003137_abnormal_impulse_conducting0.60245178

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.33932534
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.33932534
3Neurofibrillary tangles (HP:0002185)5.77606803
4Parakeratosis (HP:0001036)4.74556299
5Abnormality of the corticospinal tract (HP:0002492)4.61666015
6Sensory axonal neuropathy (HP:0003390)4.58974855
7Peripheral hypomyelination (HP:0007182)4.34831506
8Focal seizures (HP:0007359)4.14932946
9Febrile seizures (HP:0002373)4.10226265
10Cerebral inclusion bodies (HP:0100314)4.05576700
11Action tremor (HP:0002345)3.97438541
12Onion bulb formation (HP:0003383)3.86755636
13Epileptic encephalopathy (HP:0200134)3.79234066
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.76189956
15Atonic seizures (HP:0010819)3.56518513
16Alacrima (HP:0000522)3.34219303
17Supranuclear gaze palsy (HP:0000605)3.32479588
18Spastic gait (HP:0002064)3.28539387
19Generalized tonic-clonic seizures (HP:0002069)3.24756579
20Abnormal auditory evoked potentials (HP:0006958)3.24641259
21Absence seizures (HP:0002121)3.23454330
22Torticollis (HP:0000473)3.18976245
23Dysmetria (HP:0001310)3.11001722
24Cerebral hypomyelination (HP:0006808)3.09923979
25Dialeptic seizures (HP:0011146)3.05584447
26Retinal dysplasia (HP:0007973)2.95612042
27Absent septum pellucidum (HP:0001331)2.93946034
28Termporal pattern (HP:0011008)2.88985756
29Insidious onset (HP:0003587)2.88985756
30Hypoplastic pelvis (HP:0008839)2.87271743
31Tetraplegia (HP:0002445)2.86448727
32Ankle clonus (HP:0011448)2.85555094
33Intention tremor (HP:0002080)2.85205232
34Thickened helices (HP:0000391)2.84085786
35Myokymia (HP:0002411)2.80224680
36Decreased lacrimation (HP:0000633)2.76496141
37Abnormality of the septum pellucidum (HP:0007375)2.67582268
38Akinesia (HP:0002304)2.66584289
39Scanning speech (HP:0002168)2.65289717
40Congenital ichthyosiform erythroderma (HP:0007431)2.59196667
41Septo-optic dysplasia (HP:0100842)2.56536794
42Limb dystonia (HP:0002451)2.55845530
43Partial agenesis of the corpus callosum (HP:0001338)2.53556107
44Focal dystonia (HP:0004373)2.52173216
45Hemiparesis (HP:0001269)2.52049398
46Anteriorly placed anus (HP:0001545)2.51497433
47Epileptiform EEG discharges (HP:0011182)2.51426569
48Abnormal eating behavior (HP:0100738)2.51013049
49Slow saccadic eye movements (HP:0000514)2.50259117
50Autoamputation (HP:0001218)2.50168120
51Split foot (HP:0001839)2.49695279
52Increased serum pyruvate (HP:0003542)2.45804198
53Abnormality of glycolysis (HP:0004366)2.45804198
54Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44808196
55Leukodystrophy (HP:0002415)2.44648287
56Ventricular fibrillation (HP:0001663)2.44347415
57Hypoplasia of the iris (HP:0007676)2.43521996
58Bundle branch block (HP:0011710)2.42804882
59White forelock (HP:0002211)2.42636278
60Segmental peripheral demyelination/remyelination (HP:0003481)2.40747634
61Proximal tubulopathy (HP:0000114)2.40619294
62Progressive cerebellar ataxia (HP:0002073)2.39879849
63Mitral stenosis (HP:0001718)2.39009750
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38568237
65Gaze-evoked nystagmus (HP:0000640)2.37534459
66Anxiety (HP:0000739)2.36720947
67Stridor (HP:0010307)2.36510170
68Abnormality of the phalanges of the 2nd finger (HP:0009541)2.36181686
69Patchy hypopigmentation of hair (HP:0011365)2.35617427
70Impaired vibration sensation in the lower limbs (HP:0002166)2.34008336
71Drooling (HP:0002307)2.30966695
72Increased circulating renin level (HP:0000848)2.29920185
73Metabolic alkalosis (HP:0200114)2.29264911
74Status epilepticus (HP:0002133)2.28128028
75Morphological abnormality of the inner ear (HP:0011390)2.27514862
76Hypomagnesemia (HP:0002917)2.27481238
77Cupped ear (HP:0000378)2.27296421
78EEG with generalized epileptiform discharges (HP:0011198)2.25981064
79Craniofacial dystonia (HP:0012179)2.24497402
80Diminished movement (HP:0002374)2.23436779
81Aplasia involving bones of the extremities (HP:0009825)2.23295540
82Aplasia involving bones of the upper limbs (HP:0009823)2.23295540
83Aplasia of the phalanges of the hand (HP:0009802)2.23295540
84Prominent supraorbital ridges (HP:0000336)2.22677309
85Facial shape deformation (HP:0011334)2.21170606
86Potter facies (HP:0002009)2.21170606
87Clumsiness (HP:0002312)2.20712956
88Dysdiadochokinesis (HP:0002075)2.20610448
89Spastic paraparesis (HP:0002313)2.19625286
90Abnormality of the lower motor neuron (HP:0002366)2.19395537
91Dynein arm defect of respiratory motile cilia (HP:0012255)2.19165992
92Absent/shortened dynein arms (HP:0200106)2.19165992
93Premature skin wrinkling (HP:0100678)2.15908393
94Vascular calcification (HP:0004934)2.15789998
95Hand muscle atrophy (HP:0009130)2.15357228
96Spastic tetraplegia (HP:0002510)2.13885129
97Focal motor seizures (HP:0011153)2.13468231
98Azoospermia (HP:0000027)2.12475647
99Syncope (HP:0001279)2.11058549
100Cerebral hemorrhage (HP:0001342)2.10683146
101Synostosis involving the elbow (HP:0003938)2.08094979
102Humeroradial synostosis (HP:0003041)2.08094979
103Cardiovascular calcification (HP:0011915)2.07847827
104Hypoglycemic coma (HP:0001325)2.06883094
105Partial duplication of thumb phalanx (HP:0009944)2.05271726
106Hypsarrhythmia (HP:0002521)2.05231839
107Decreased motor nerve conduction velocity (HP:0003431)2.03016276
108Anomalous pulmonary venous return (HP:0010772)2.02662031
109Coronal craniosynostosis (HP:0004440)2.00228331
110Broad-based gait (HP:0002136)1.99479326
111Foot dorsiflexor weakness (HP:0009027)1.99419933
112Prolonged QT interval (HP:0001657)1.98920788
113Hypophosphatemic rickets (HP:0004912)1.98409535
114Excessive salivation (HP:0003781)1.97243041
115Chin dimple (HP:0010751)1.96971753
116CNS hypomyelination (HP:0003429)1.96090698
117Congenital sensorineural hearing impairment (HP:0008527)1.95303301
118Pheochromocytoma (HP:0002666)1.92930099
119Adrenal hypoplasia (HP:0000835)1.92779764
120Diplopia (HP:0000651)1.91653639
121Abnormality of binocular vision (HP:0011514)1.91653639
122Myelomeningocele (HP:0002475)1.91196159
123Conical tooth (HP:0000698)1.90969552
124Muscle fiber splitting (HP:0003555)1.90758749
125Abnormality of the middle phalanges of the toes (HP:0010183)1.90233370
126Hypokalemic alkalosis (HP:0001949)1.87139264
127Steppage gait (HP:0003376)1.86951791
128Amyotrophic lateral sclerosis (HP:0007354)1.86488268
129Hepatosplenomegaly (HP:0001433)1.86207187
130Fat malabsorption (HP:0002630)1.86199483
131Vaginal atresia (HP:0000148)1.85748088
132Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85410243
133Megalencephaly (HP:0001355)1.85002861
134Lower limb muscle weakness (HP:0007340)1.84879446
135Methylmalonic acidemia (HP:0002912)1.84756493
136Generalized myoclonic seizures (HP:0002123)1.84282754
137Spastic tetraparesis (HP:0001285)1.83302522
138Postural instability (HP:0002172)1.82867391
139Depression (HP:0000716)1.82757187
140Infantile muscular hypotonia (HP:0008947)1.81930410
141Prolonged neonatal jaundice (HP:0006579)1.81829883
142Morphological abnormality of the pyramidal tract (HP:0002062)1.80641215
143Abnormality of vitamin metabolism (HP:0100508)1.79730439
144Menstrual irregularities (HP:0000858)1.79285849
145Genital tract atresia (HP:0001827)1.77390240
146Abnormality of the foot musculature (HP:0001436)1.77389491
147Bowel incontinence (HP:0002607)1.76978524
148Duplicated collecting system (HP:0000081)1.76402544
149Blue irides (HP:0000635)1.76385874
150Poor speech (HP:0002465)1.75874839
151Hyperventilation (HP:0002883)1.75633554
152Hammertoe (HP:0001765)1.75176235
153Esophageal atresia (HP:0002032)1.75026446
154Abnormality of the pulmonary veins (HP:0011718)1.74567453
155Abnormal EKG (HP:0003115)1.73685668
156Urinary incontinence (HP:0000020)1.73201154
157Poor eye contact (HP:0000817)1.72161849
158Absent speech (HP:0001344)1.70249157
159Abnormality of the labia minora (HP:0012880)1.68604377
160Postural tremor (HP:0002174)1.65783958
161Atrial fibrillation (HP:0005110)1.65707943
162Osteomalacia (HP:0002749)1.65645830
163Short chin (HP:0000331)1.63452296
164Hypothermia (HP:0002045)1.62656391
165Abnormality of vitamin B metabolism (HP:0004340)1.62175147
166Striae distensae (HP:0001065)1.60997610
167Upper limb amyotrophy (HP:0009129)1.60715140
168Distal upper limb amyotrophy (HP:0007149)1.60715140
169Abnormality of urine glucose concentration (HP:0011016)1.60280154
170Glycosuria (HP:0003076)1.60280154
171Hypoplasia of the fovea (HP:0007750)1.59417210
172Aplasia/Hypoplasia of the fovea (HP:0008060)1.59417210
173Abnormality of renin-angiotensin system (HP:0000847)1.56687102
174Urethral obstruction (HP:0000796)1.56527508
175Visual hallucinations (HP:0002367)1.55908588
176Primary atrial arrhythmia (HP:0001692)1.55579551
177Hydroureter (HP:0000072)1.55417528
178Abnormality of ocular smooth pursuit (HP:0000617)1.55241820
179Amblyopia (HP:0000646)1.55073804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.17456667
2OXSR14.35634989
3NME13.14769774
4DAPK23.01563249
5FRK2.90978993
6EPHB12.78956007
7PKN12.77206695
8BCR2.58667429
9WNK42.49491181
10TNIK2.36319564
11CASK2.33592085
12MAP3K92.32389802
13MAP3K122.31789535
14MAPKAPK52.28463848
15PBK2.18091140
16CDK192.17560439
17PINK12.06254985
18PNCK2.00771559
19LIMK11.96073087
20MET1.93958638
21WNK11.85921147
22FGFR21.84891225
23EPHA41.74889239
24MAP3K41.72118178
25CSNK1G31.70349692
26CSNK1A1L1.69497573
27NEK61.66715343
28UHMK11.57767492
29PRKD31.56709546
30CAMK2B1.56229333
31PRPF4B1.54697966
32NTRK11.43308271
33MINK11.41195207
34ROCK21.40701642
35CSNK1G11.38359153
36LATS21.35197906
37PAK61.34618992
38PRKCG1.33552220
39CSNK1G21.29066721
40CLK11.28735532
41AKT31.28426362
42FGR1.27926070
43CAMK11.25636453
44ICK1.24743840
45MARK11.23460310
46CAMK2D1.22852786
47MYLK1.18505360
48STK38L1.18367275
49CAMKK21.15931140
50MAPK151.13443445
51BMPR1B1.13090800
52DAPK11.04862523
53SGK2231.04376957
54SGK4941.04376957
55CAMKK11.04044415
56IRAK20.99669752
57TESK10.98415026
58MST40.98173590
59PAK30.97663738
60CAMK2G0.96618076
61DYRK20.96483547
62CAMK2A0.94800308
63MARK20.88234293
64ERBB30.86285267
65MAP3K20.83315421
66PRKCQ0.81971931
67STK240.81397124
68TYRO30.80719506
69LATS10.80042553
70PHKG10.77670226
71PHKG20.77670226
72CAMK40.77600046
73MAP2K40.77132366
74CDK50.75968221
75STK160.75560113
76STK380.74715674
77PRKCE0.74421306
78MAP3K130.74216788
79CDK140.73418046
80MAP2K60.72035137
81TESK20.71932127
82PRKCZ0.71920950
83MAP2K70.68824644
84PRKD10.68506423
85BRSK10.68501820
86TIE10.68461873
87SGK10.67218704
88WNK30.65941334
89MKNK10.65918300
90ERBB40.65176527
91MUSK0.64902056
92CDK150.64200259
93TRPM70.64027496
94BLK0.63480819
95SIK20.63102842
96IRAK10.61939670
97FER0.61774297
98SGK20.60820943
99CDK180.60697101
100PDPK10.60291307
101NTRK20.60078387
102MAPK130.59815919
103PRKG10.58292119
104CDK11A0.58172471
105GRK70.56946746
106CAMK1G0.55922632
107GRK10.55763842
108MAP2K20.55316855
109STK30.54993118
110ARAF0.53940408
111FYN0.53743483
112NTRK30.53524836
113ADRBK20.53100778
114ROCK10.52098973
115RPS6KA30.51647475
116RPS6KA50.48188108
117CSNK1D0.47942557
118FES0.47795874
119PIK3CA0.47331554
120DAPK30.45055954
121STK110.44847054
122RPS6KB10.43363037
123MKNK20.42736203
124PRKG20.42103674
125CSNK1A10.41932134
126MAPK100.41384566
127PRKCA0.41030736
128KSR20.39815936
129FGFR30.39656877
130INSRR0.38341024
131GSK3A0.36022528
132DYRK1A0.34730569
133DMPK0.34223904
134BMPR20.34145197
135PRKACB0.33573171
136MAPK70.32595507
137CDK30.31807464
138PRKACA0.31742285
139OBSCN0.29427442
140CSNK1E0.29082151
141PRKD20.29014474
142PRKCH0.28223333
143PLK20.26800856
144PAK10.25821012
145GRK50.25616185

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.96558365
2Steroid biosynthesis_Homo sapiens_hsa001004.31241233
3Fatty acid elongation_Homo sapiens_hsa000623.95156390
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.24002015
5Ether lipid metabolism_Homo sapiens_hsa005653.06191105
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.56797455
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53596674
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20000078
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06401546
10Axon guidance_Homo sapiens_hsa043601.93176962
11Sulfur metabolism_Homo sapiens_hsa009201.81263200
12Protein export_Homo sapiens_hsa030601.80777060
13Linoleic acid metabolism_Homo sapiens_hsa005911.80447789
14Histidine metabolism_Homo sapiens_hsa003401.77889396
15Oxidative phosphorylation_Homo sapiens_hsa001901.75033026
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69575833
17Sphingolipid metabolism_Homo sapiens_hsa006001.67561589
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61127395
19Glutamatergic synapse_Homo sapiens_hsa047241.51563456
20Serotonergic synapse_Homo sapiens_hsa047261.51460946
21Arginine biosynthesis_Homo sapiens_hsa002201.49297435
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.49091772
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48965739
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45476693
25Vitamin B6 metabolism_Homo sapiens_hsa007501.41453860
26GABAergic synapse_Homo sapiens_hsa047271.39898958
27Butanoate metabolism_Homo sapiens_hsa006501.35431332
28Bile secretion_Homo sapiens_hsa049761.34380223
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31288404
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28453704
31Nicotine addiction_Homo sapiens_hsa050331.27448473
32Morphine addiction_Homo sapiens_hsa050321.23333312
33Fat digestion and absorption_Homo sapiens_hsa049751.22818990
34Alzheimers disease_Homo sapiens_hsa050101.21740437
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21629910
36Long-term depression_Homo sapiens_hsa047301.19968184
37Circadian rhythm_Homo sapiens_hsa047101.18681324
38Thyroid hormone synthesis_Homo sapiens_hsa049181.15732551
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11687851
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.11078338
41Phototransduction_Homo sapiens_hsa047441.08342380
42Arginine and proline metabolism_Homo sapiens_hsa003301.08073926
43Folate biosynthesis_Homo sapiens_hsa007901.07828577
44Parkinsons disease_Homo sapiens_hsa050121.07778176
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06914680
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05850976
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03370777
48Renal cell carcinoma_Homo sapiens_hsa052110.99581348
49Collecting duct acid secretion_Homo sapiens_hsa049660.97859343
50Oocyte meiosis_Homo sapiens_hsa041140.96127242
51Protein digestion and absorption_Homo sapiens_hsa049740.95845150
52Olfactory transduction_Homo sapiens_hsa047400.94980205
53Nitrogen metabolism_Homo sapiens_hsa009100.94119338
54Arachidonic acid metabolism_Homo sapiens_hsa005900.92171023
55Salivary secretion_Homo sapiens_hsa049700.90478835
56Tight junction_Homo sapiens_hsa045300.90448176
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90334676
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.90182618
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89996810
60Inositol phosphate metabolism_Homo sapiens_hsa005620.89944775
61Ovarian steroidogenesis_Homo sapiens_hsa049130.88636645
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88153097
63Circadian entrainment_Homo sapiens_hsa047130.86515172
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86496755
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86472028
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.86446952
67Cocaine addiction_Homo sapiens_hsa050300.86352737
68Vibrio cholerae infection_Homo sapiens_hsa051100.83605089
69Cardiac muscle contraction_Homo sapiens_hsa042600.81253851
70Ras signaling pathway_Homo sapiens_hsa040140.79054734
71Autoimmune thyroid disease_Homo sapiens_hsa053200.78205856
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.77439628
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.76225473
74beta-Alanine metabolism_Homo sapiens_hsa004100.75304760
75Pancreatic secretion_Homo sapiens_hsa049720.74644248
76Renin-angiotensin system_Homo sapiens_hsa046140.73023379
77Gastric acid secretion_Homo sapiens_hsa049710.70883409
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70788370
79Dorso-ventral axis formation_Homo sapiens_hsa043200.69740796
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.69480219
81Taste transduction_Homo sapiens_hsa047420.69430623
82Rheumatoid arthritis_Homo sapiens_hsa053230.67839349
83ErbB signaling pathway_Homo sapiens_hsa040120.65501677
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64595501
85Glutathione metabolism_Homo sapiens_hsa004800.64338307
86Dopaminergic synapse_Homo sapiens_hsa047280.64228330
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63826485
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.63735964
89Renin secretion_Homo sapiens_hsa049240.62927648
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62761592
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.62706002
92Fatty acid degradation_Homo sapiens_hsa000710.62395384
93Cholinergic synapse_Homo sapiens_hsa047250.62070764
94Hedgehog signaling pathway_Homo sapiens_hsa043400.61852107
95Glucagon signaling pathway_Homo sapiens_hsa049220.60800868
96ABC transporters_Homo sapiens_hsa020100.60696147
97Tryptophan metabolism_Homo sapiens_hsa003800.60303359
98Amphetamine addiction_Homo sapiens_hsa050310.57489383
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56984175
100Mineral absorption_Homo sapiens_hsa049780.56778830
101PPAR signaling pathway_Homo sapiens_hsa033200.56574679
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55660983
103Synaptic vesicle cycle_Homo sapiens_hsa047210.54460293
104Dilated cardiomyopathy_Homo sapiens_hsa054140.53051207
105Regulation of autophagy_Homo sapiens_hsa041400.52222695
106GnRH signaling pathway_Homo sapiens_hsa049120.50952458
107Endocytosis_Homo sapiens_hsa041440.50677869
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50488367
109Tyrosine metabolism_Homo sapiens_hsa003500.50123627
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49662108
111Huntingtons disease_Homo sapiens_hsa050160.49389571
112Fatty acid metabolism_Homo sapiens_hsa012120.49103242
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48029228
114Retinol metabolism_Homo sapiens_hsa008300.47968880
115Fatty acid biosynthesis_Homo sapiens_hsa000610.47727467
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47474732
117cAMP signaling pathway_Homo sapiens_hsa040240.47450128
118ECM-receptor interaction_Homo sapiens_hsa045120.44137254
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44042722
120Choline metabolism in cancer_Homo sapiens_hsa052310.43996237
121Gap junction_Homo sapiens_hsa045400.43646332
122Calcium signaling pathway_Homo sapiens_hsa040200.43495780
123Phagosome_Homo sapiens_hsa041450.41527427
124Long-term potentiation_Homo sapiens_hsa047200.39063712
125Wnt signaling pathway_Homo sapiens_hsa043100.38943271
126Insulin secretion_Homo sapiens_hsa049110.38676811
127Propanoate metabolism_Homo sapiens_hsa006400.38380884
128Vitamin digestion and absorption_Homo sapiens_hsa049770.38137436
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37368574
130Peroxisome_Homo sapiens_hsa041460.37138814
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37015309
132Oxytocin signaling pathway_Homo sapiens_hsa049210.36891043
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34939354
134Chemical carcinogenesis_Homo sapiens_hsa052040.34320312
135Melanogenesis_Homo sapiens_hsa049160.34228072
136Lysosome_Homo sapiens_hsa041420.32636394

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