STYX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.69919886
2ribosomal small subunit assembly (GO:0000028)5.53109699
3deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.37924100
4telomere maintenance via semi-conservative replication (GO:0032201)4.33217723
5viral mRNA export from host cell nucleus (GO:0046784)4.24316807
6regulation of centriole replication (GO:0046599)4.12276537
7DNA strand elongation involved in DNA replication (GO:0006271)4.09981992
8proteasome assembly (GO:0043248)4.03948518
9DNA strand elongation (GO:0022616)4.02584193
10DNA double-strand break processing (GO:0000729)3.95033366
11telomere maintenance via recombination (GO:0000722)3.82898841
12kinetochore assembly (GO:0051382)3.78474268
13regulation of helicase activity (GO:0051095)3.77320606
14RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.69023963
15kinetochore organization (GO:0051383)3.57031217
16regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.56411650
17regulation of mitotic spindle checkpoint (GO:1903504)3.56411650
18negative regulation of DNA-dependent DNA replication (GO:2000104)3.56183937
19pyrimidine nucleotide catabolic process (GO:0006244)3.53823300
20pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.52061621
21ribosome assembly (GO:0042255)3.51349571
22CENP-A containing nucleosome assembly (GO:0034080)3.51074005
23mitotic sister chromatid cohesion (GO:0007064)3.44090177
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43054086
25mitotic G2/M transition checkpoint (GO:0044818)3.41851993
26DNA replication initiation (GO:0006270)3.40944323
272-deoxyribonucleotide biosynthetic process (GO:0009265)3.39931046
28deoxyribose phosphate biosynthetic process (GO:0046385)3.39931046
29respiratory chain complex IV assembly (GO:0008535)3.37776327
30platelet dense granule organization (GO:0060155)3.37719744
31nucleobase biosynthetic process (GO:0046112)3.35464420
32telomere maintenance via telomere lengthening (GO:0010833)3.33996573
33somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.33714005
34somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.33714005
35isotype switching (GO:0045190)3.33714005
36pseudouridine synthesis (GO:0001522)3.33422813
37mitotic recombination (GO:0006312)3.31604532
38chromatin remodeling at centromere (GO:0031055)3.29298415
39IMP biosynthetic process (GO:0006188)3.25437014
40purine nucleobase biosynthetic process (GO:0009113)3.25203194
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.25187661
42negative regulation of DNA recombination (GO:0045910)3.23624936
43cytochrome complex assembly (GO:0017004)3.22001783
44histone exchange (GO:0043486)3.20139030
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.19768097
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19768097
47tRNA methylation (GO:0030488)3.19504882
48deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.15721577
49metaphase plate congression (GO:0051310)3.15569003
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15238776
51establishment of integrated proviral latency (GO:0075713)3.14597149
52mitotic G2 DNA damage checkpoint (GO:0007095)3.14146571
53DNA replication-dependent nucleosome assembly (GO:0006335)3.12252952
54DNA replication-dependent nucleosome organization (GO:0034723)3.12252952
55maturation of SSU-rRNA (GO:0030490)3.10257330
56regulation of meiosis I (GO:0060631)3.10238684
57mitotic metaphase plate congression (GO:0007080)3.09237273
58spliceosomal snRNP assembly (GO:0000387)3.08905478
59deoxyribonucleotide biosynthetic process (GO:0009263)3.07053909
60response to X-ray (GO:0010165)3.05202580
61signal peptide processing (GO:0006465)3.04030091
62mitochondrial RNA metabolic process (GO:0000959)2.99130780
63negative regulation of mitotic sister chromatid separation (GO:2000816)2.97177656
64negative regulation of sister chromatid segregation (GO:0033046)2.97177656
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97177656
66negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97177656
67negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97177656
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96841577
69transcription elongation from RNA polymerase III promoter (GO:0006385)2.96806586
70termination of RNA polymerase III transcription (GO:0006386)2.96806586
71nuclear pore complex assembly (GO:0051292)2.96687796
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96384315
73histone-serine phosphorylation (GO:0035404)2.96057420
74protein K6-linked ubiquitination (GO:0085020)2.94809038
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94464696
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94007905
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93711301
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93711301
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93711301
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93675113
81GMP metabolic process (GO:0046037)2.93663441
82deoxyribonucleotide metabolic process (GO:0009262)2.93335697
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91773816
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91773816
85regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91088413
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91088413
87protein K11-linked deubiquitination (GO:0035871)2.90927726
887-methylguanosine mRNA capping (GO:0006370)2.90099563
89ribosome biogenesis (GO:0042254)2.89591817
90deoxyribonucleotide catabolic process (GO:0009264)2.89307302
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88621560
927-methylguanosine RNA capping (GO:0009452)2.88086166
93RNA capping (GO:0036260)2.88086166
94recombinational repair (GO:0000725)2.87361291
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86483833
96telomere maintenance (GO:0000723)2.85559037
97double-strand break repair via homologous recombination (GO:0000724)2.85109392
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84875324
99telomere organization (GO:0032200)2.84799295
100negative regulation of chromosome segregation (GO:0051985)2.84034357
101L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.83753314
102tRNA modification (GO:0006400)2.83442783
103tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83385407
104RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83385407
105mitotic spindle checkpoint (GO:0071174)2.83296968
106postreplication repair (GO:0006301)2.83025433
1072-deoxyribonucleotide metabolic process (GO:0009394)2.82210105
108negative regulation of ligase activity (GO:0051352)2.82109139
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82109139
110nuclear pore organization (GO:0006999)2.81229703
111regulation of centrosome duplication (GO:0010824)2.80634178
112IMP metabolic process (GO:0046040)2.80602867
113transcription-coupled nucleotide-excision repair (GO:0006283)2.80513394
114DNA replication-independent nucleosome organization (GO:0034724)2.80506854
115DNA replication-independent nucleosome assembly (GO:0006336)2.80506854
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80472069
117iron-sulfur cluster assembly (GO:0016226)2.79059894
118metallo-sulfur cluster assembly (GO:0031163)2.79059894
119spindle checkpoint (GO:0031577)2.77719971
120regulation of centrosome cycle (GO:0046605)2.77478261
121negative regulation of translation, ncRNA-mediated (GO:0040033)2.77221676
122regulation of translation, ncRNA-mediated (GO:0045974)2.77221676
123negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.77221676
124adenosine metabolic process (GO:0046085)2.77162514
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.76727076
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76727076
127histone mRNA metabolic process (GO:0008334)2.76491849
128endosome to melanosome transport (GO:0035646)2.75802568
129endosome to pigment granule transport (GO:0043485)2.75802568
130regulation of sister chromatid segregation (GO:0033045)2.75544141
131regulation of mitotic sister chromatid separation (GO:0010965)2.75544141
132regulation of mitotic sister chromatid segregation (GO:0033047)2.75544141
133mismatch repair (GO:0006298)2.75407508
134neural tube formation (GO:0001841)2.75337836
135signal transduction involved in cell cycle checkpoint (GO:0072395)2.75094792
136DNA catabolic process, exonucleolytic (GO:0000738)2.73843482
137peptidyl-histidine modification (GO:0018202)2.73589126
138formation of translation preinitiation complex (GO:0001731)2.73182005
139somatic recombination of immunoglobulin gene segments (GO:0016447)2.72632995
140regulation of nuclear cell cycle DNA replication (GO:0033262)2.72082417
141DNA replication checkpoint (GO:0000076)2.71588826
142establishment of chromosome localization (GO:0051303)2.71078550
143ribonucleoprotein complex biogenesis (GO:0022613)2.70074050
144rRNA modification (GO:0000154)2.68411616
145mitotic spindle assembly checkpoint (GO:0007094)2.68041538
146deoxyribose phosphate metabolic process (GO:0019692)2.67910532
147replication fork processing (GO:0031297)2.66830767
148mitochondrial DNA replication (GO:0006264)2.66551897
149histone mRNA catabolic process (GO:0071044)2.65489660
150regulation of cellular amino acid metabolic process (GO:0006521)2.65016301
151tRNA processing (GO:0008033)2.65015391
152monoubiquitinated protein deubiquitination (GO:0035520)2.64774851
153deoxyribose phosphate catabolic process (GO:0046386)2.64692345
154regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64621109
155SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64167675
156protein complex biogenesis (GO:0070271)2.63955649
157spindle assembly checkpoint (GO:0071173)2.63832523
158somatic cell DNA recombination (GO:0016444)2.62196197
159somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.62196197
160somatic diversification of immunoglobulins (GO:0016445)2.60490957
161L-serine metabolic process (GO:0006563)2.60454395
162purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.59840590
163guanosine-containing compound biosynthetic process (GO:1901070)2.59779399
164response to interferon-beta (GO:0035456)2.58702089
165transcription from mitochondrial promoter (GO:0006390)2.57697180
166protein deneddylation (GO:0000338)2.57260773
167DNA-dependent DNA replication (GO:0006261)2.56742067
168protein localization to kinetochore (GO:0034501)2.56371100
169cotranslational protein targeting to membrane (GO:0006613)2.56111715
170cellular component biogenesis (GO:0044085)2.55583973
171pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.55026077
172establishment of viral latency (GO:0019043)2.54711501
173ribosomal small subunit biogenesis (GO:0042274)2.54507741
174purine-containing compound salvage (GO:0043101)2.54495618
175somatic diversification of immune receptors (GO:0002200)2.54296681
176protein neddylation (GO:0045116)2.53002822
177branched-chain amino acid catabolic process (GO:0009083)2.52814056
178mitochondrial respiratory chain complex assembly (GO:0033108)2.52359632
179regulation of coenzyme metabolic process (GO:0051196)2.51324276
180regulation of cofactor metabolic process (GO:0051193)2.51324276
181regulation of DNA endoreduplication (GO:0032875)2.50985291
182regulation of chromatin silencing (GO:0031935)2.50607883
183attachment of spindle microtubules to kinetochore (GO:0008608)2.50313541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.04943007
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.82708910
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76888463
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43317215
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.41579882
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.34786288
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.21747522
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.21237197
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14317819
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05586586
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76073717
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.70714897
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.70363197
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67211037
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63213822
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.61994932
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58803891
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56888477
19VDR_23849224_ChIP-Seq_CD4+_Human2.55131209
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53015304
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51381551
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50781771
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.43472735
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.40317851
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38226006
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.33046859
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30618599
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28863976
29HOXB4_20404135_ChIP-ChIP_EML_Mouse2.21946780
30FOXP3_21729870_ChIP-Seq_TREG_Human2.18248203
31ELK1_19687146_ChIP-ChIP_HELA_Human2.17598284
32ZNF274_21170338_ChIP-Seq_K562_Hela2.17521445
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12984268
34ERG_20887958_ChIP-Seq_HPC-7_Mouse2.02539280
35DCP1A_22483619_ChIP-Seq_HELA_Human2.01923075
36FUS_26573619_Chip-Seq_HEK293_Human2.01806779
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01082113
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99692768
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.97413550
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.97082258
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96171379
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.95326192
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94770274
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94361307
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91024433
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90529016
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88208783
48GABP_19822575_ChIP-Seq_HepG2_Human1.88147189
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.88085958
50TAF15_26573619_Chip-Seq_HEK293_Human1.85890468
51XRN2_22483619_ChIP-Seq_HELA_Human1.82253208
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74128016
53TTF2_22483619_ChIP-Seq_HELA_Human1.74027248
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73954785
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.67320075
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67261097
57SPI1_23547873_ChIP-Seq_NB4_Human1.67219460
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65580147
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65326455
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65300130
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64923901
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63829887
63VDR_22108803_ChIP-Seq_LS180_Human1.62241392
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.61310961
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.54426314
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.53746910
67CIITA_25753668_ChIP-Seq_RAJI_Human1.53612224
68SCL_19346495_ChIP-Seq_HPC-7_Human1.52454462
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47545004
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45468295
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45314287
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39188038
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.37967020
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37176498
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36279195
76ER_23166858_ChIP-Seq_MCF-7_Human1.35421098
77P300_19829295_ChIP-Seq_ESCs_Human1.33773651
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29904499
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28690378
80MYC_18940864_ChIP-ChIP_HL60_Human1.24995587
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24918402
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.21053126
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20525080
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19237125
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16814096
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.15874921
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15665984
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15525602
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13326803
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12995216
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12707294
92EWS_26573619_Chip-Seq_HEK293_Human1.12706943
93* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12509968
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11565189
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10363790
96ELK1_22589737_ChIP-Seq_MCF10A_Human1.10314252
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09276775
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08659522
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.08517242
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08442916
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08088388
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07195802
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.06299379
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05910680
105AR_21909140_ChIP-Seq_LNCAP_Human1.03942203
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02528499
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02409441
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.01162884
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01106213
110POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00501412
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00500127
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00114282
113GATA1_22025678_ChIP-Seq_K562_Human0.99834344
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99819299
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99372852
116CBP_20019798_ChIP-Seq_JUKART_Human0.99372852
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99122528
118CDX2_22108803_ChIP-Seq_LS180_Human0.98687992
119NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98384804
120GATA3_26560356_Chip-Seq_TH2_Human0.96867339
121IGF1R_20145208_ChIP-Seq_DFB_Human0.94471010
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94300900
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94163361
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94163361
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94163361
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94059608
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93933274
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92927883
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92691614
130GBX2_23144817_ChIP-Seq_PC3_Human0.92219920
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91287781
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90746548
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90694335
134SALL4_22934838_ChIP-ChIP_CD34+_Human0.87536778
135CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87354165
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87270915
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85828442
138OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85595404
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84463948
140IRF1_19129219_ChIP-ChIP_H3396_Human0.84126987
141TFEB_21752829_ChIP-Seq_HELA_Human0.83418762
142KDM5A_27292631_Chip-Seq_BREAST_Human0.83081728
143CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82481068
144MYB_26560356_Chip-Seq_TH2_Human0.80960622
145TP63_19390658_ChIP-ChIP_HaCaT_Human0.79580613
146* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.76073838
147IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74765166
148TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72412856
149EGR1_19374776_ChIP-ChIP_THP-1_Human0.72129075
150POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.71837486
151PU.1_20513432_ChIP-Seq_Bcells_Mouse0.70356161
152GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70247250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.81422816
2MP0001835_abnormal_antigen_presentation3.30065144
3MP0010094_abnormal_chromosome_stability3.14687491
4MP0003693_abnormal_embryo_hatching3.13423097
5MP0002396_abnormal_hematopoietic_system2.94524090
6MP0008058_abnormal_DNA_repair2.58130500
7MP0009785_altered_susceptibility_to2.47184117
8MP0001188_hyperpigmentation2.44643621
9MP0008007_abnormal_cellular_replicative2.44099362
10MP0008057_abnormal_DNA_replication2.41317745
11MP0000015_abnormal_ear_pigmentation2.39461550
12MP0003941_abnormal_skin_development2.33385151
13MP0005671_abnormal_response_to2.32448373
14MP0006292_abnormal_olfactory_placode2.24699960
15MP0002163_abnormal_gland_morphology2.19327369
16MP0002148_abnormal_hypersensitivity_rea2.17908950
17MP0005174_abnormal_tail_pigmentation2.17777950
18MP0003077_abnormal_cell_cycle2.16267920
19MP0003890_abnormal_embryonic-extraembry2.14018107
20MP0003111_abnormal_nucleus_morphology2.13902886
21MP0005075_abnormal_melanosome_morpholog2.11527156
22MP0000566_synostosis2.00405005
23MP0002132_abnormal_respiratory_system2.00366706
24MP0009333_abnormal_splenocyte_physiolog1.98306212
25MP0003763_abnormal_thymus_physiology1.97183322
26MP0009697_abnormal_copulation1.93480815
27MP0002095_abnormal_skin_pigmentation1.93191841
28MP0010352_gastrointestinal_tract_polyps1.92651369
29MP0004957_abnormal_blastocyst_morpholog1.91768620
30MP0008877_abnormal_DNA_methylation1.91325261
31MP0003786_premature_aging1.91276680
32MP0000490_abnormal_crypts_of1.89098485
33MP0003787_abnormal_imprinting1.75608721
34MP0001293_anophthalmia1.74937137
35MP0000569_abnormal_digit_pigmentation1.73787467
36MP0003195_calcinosis1.73704454
37MP0006054_spinal_hemorrhage1.73378523
38MP0004808_abnormal_hematopoietic_stem1.70623197
39MP0000427_abnormal_hair_cycle1.63810705
40MP0005000_abnormal_immune_tolerance1.63529122
41MP0002398_abnormal_bone_marrow1.62653199
42MP0003718_maternal_effect1.62212265
43MP0001545_abnormal_hematopoietic_system1.61202279
44MP0005397_hematopoietic_system_phenotyp1.61202279
45MP0001986_abnormal_taste_sensitivity1.60620830
46MP0003806_abnormal_nucleotide_metabolis1.55399057
47MP0001853_heart_inflammation1.53792820
48MP0005025_abnormal_response_to1.53651432
49MP0003186_abnormal_redox_activity1.52853717
50MP0002138_abnormal_hepatobiliary_system1.52232884
51MP0008995_early_reproductive_senescence1.51360621
52MP0003724_increased_susceptibility_to1.50550753
53MP0002420_abnormal_adaptive_immunity1.50442390
54MP0001819_abnormal_immune_cell1.49271644
55MP0002419_abnormal_innate_immunity1.48395947
56MP0002452_abnormal_antigen_presenting1.47943631
57MP0000685_abnormal_immune_system1.45663594
58MP0003123_paternal_imprinting1.43597930
59MP0005379_endocrine/exocrine_gland_phen1.42732283
60MP0002723_abnormal_immune_serum1.42016452
61MP0001800_abnormal_humoral_immune1.38198048
62MP0000689_abnormal_spleen_morphology1.36713835
63MP0009379_abnormal_foot_pigmentation1.36085880
64MP0002938_white_spotting1.35838205
65MP0000716_abnormal_immune_system1.35194037
66MP0003221_abnormal_cardiomyocyte_apopto1.33876054
67MP0000465_gastrointestinal_hemorrhage1.33470118
68MP0010678_abnormal_skin_adnexa1.31761881
69MP0004782_abnormal_surfactant_physiolog1.31657206
70MP0002429_abnormal_blood_cell1.29641280
71MP0002722_abnormal_immune_system1.28520778
72MP0001661_extended_life_span1.26315195
73MP0002638_abnormal_pupillary_reflex1.22703564
74MP0010386_abnormal_urinary_bladder1.22280138
75MP0010234_abnormal_vibrissa_follicle1.20382420
76MP0004147_increased_porphyrin_level1.18963037
77MP0001672_abnormal_embryogenesis/_devel1.18781899
78MP0005380_embryogenesis_phenotype1.18781899
79MP0003436_decreased_susceptibility_to1.18730006
80MP0001697_abnormal_embryo_size1.17405144
81MP0005464_abnormal_platelet_physiology1.17315759
82MP0003943_abnormal_hepatobiliary_system1.15857113
83MP0001730_embryonic_growth_arrest1.15279795
84MP0003252_abnormal_bile_duct1.14355956
85MP0003984_embryonic_growth_retardation1.14128395
86MP0006035_abnormal_mitochondrial_morpho1.14062167
87MP0002088_abnormal_embryonic_growth/wei1.13030141
88MP0000372_irregular_coat_pigmentation1.12501866
89MP0000313_abnormal_cell_death1.12337448
90MP0000383_abnormal_hair_follicle1.12219994
91MP0003121_genomic_imprinting1.10360377
92MP0002006_tumorigenesis1.09651645
93MP0003937_abnormal_limbs/digits/tail_de1.07702112
94MP0008932_abnormal_embryonic_tissue1.07633507
95MP0005084_abnormal_gallbladder_morpholo1.05442042
96MP0001790_abnormal_immune_system1.03850953
97MP0005387_immune_system_phenotype1.03850953
98MP0006036_abnormal_mitochondrial_physio1.02749384
99MP0010307_abnormal_tumor_latency1.02528906
100MP0001186_pigmentation_phenotype0.97990306
101MP0000703_abnormal_thymus_morphology0.97090440
102MP0004484_altered_response_of0.96991365
103MP0002084_abnormal_developmental_patter0.96448345
104MP0002086_abnormal_extraembryonic_tissu0.95427280
105MP0004197_abnormal_fetal_growth/weight/0.92687909
106MP0004215_abnormal_myocardial_fiber0.92406117
107MP0005408_hypopigmentation0.92188699
108MP0001919_abnormal_reproductive_system0.91917048
109MP0001119_abnormal_female_reproductive0.91440608
110MP0002089_abnormal_postnatal_growth/wei0.91281426
111MP0010030_abnormal_orbit_morphology0.89720783
112MP0001764_abnormal_homeostasis0.89401530
113MP0002796_impaired_skin_barrier0.89014153
114MP0002019_abnormal_tumor_incidence0.88540194
115MP0002405_respiratory_system_inflammati0.87189654
116MP0006072_abnormal_retinal_apoptosis0.86397517
117MP0002166_altered_tumor_susceptibility0.86149485
118MP0002075_abnormal_coat/hair_pigmentati0.86057030
119MP0005085_abnormal_gallbladder_physiolo0.85781378
120MP0000681_abnormal_thyroid_gland0.85554934
121MP0000350_abnormal_cell_proliferation0.85387584
122MP0000358_abnormal_cell_content/0.84626967
123MP0005647_abnormal_sex_gland0.83775081
124MP0010155_abnormal_intestine_physiology0.83752930
125MP0000647_abnormal_sebaceous_gland0.83483176
126MP0001845_abnormal_inflammatory_respons0.83063316
127MP0001873_stomach_inflammation0.82461543
128MP0003656_abnormal_erythrocyte_physiolo0.82019860
129MP0002210_abnormal_sex_determination0.81257037
130MP0005409_darkened_coat_color0.80979651
131MP0002090_abnormal_vision0.79926216
132MP0000858_altered_metastatic_potential0.79399630
133MP0002102_abnormal_ear_morphology0.78423778
134MP0005167_abnormal_blood-brain_barrier0.75753919
135MP0002009_preneoplasia0.75597363
136MP0009703_decreased_birth_body0.75371303
137MP0001324_abnormal_eye_pigmentation0.75298765
138MP0001915_intracranial_hemorrhage0.75080413
139MP0002080_prenatal_lethality0.73521266
140MP0002933_joint_inflammation0.72844672
141MP0005253_abnormal_eye_physiology0.72773286
142MP0001177_atelectasis0.72516490
143MP0008260_abnormal_autophagy0.72498404
144MP0002085_abnormal_embryonic_tissue0.72027298
145MP0005395_other_phenotype0.71479969
146MP0001286_abnormal_eye_development0.71281021
147MP0008469_abnormal_protein_level0.71231140
148MP0005389_reproductive_system_phenotype0.70214857
149MP0003646_muscle_fatigue0.69824649
150MP0001191_abnormal_skin_condition0.68526544
151MP0000343_altered_response_to0.68037832
152MP0003567_abnormal_fetal_cardiomyocyte0.67473744
153MP0002876_abnormal_thyroid_physiology0.67415438
154* MP0001929_abnormal_gametogenesis0.67239964

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)3.94394932
2Abnormality of the heme biosynthetic pathway (HP:0010472)3.64972792
3Type I transferrin isoform profile (HP:0003642)3.64443041
4T lymphocytopenia (HP:0005403)3.62357626
5Abnormal number of erythroid precursors (HP:0012131)3.43536248
6Abnormality of T cell number (HP:0011839)3.41713249
7Abnormality of the anterior horn cell (HP:0006802)3.31508986
8Degeneration of anterior horn cells (HP:0002398)3.31508986
9Abnormality of chromosome stability (HP:0003220)3.27759838
10Severe visual impairment (HP:0001141)3.20186801
11Myositis (HP:0100614)3.08546065
12Abnormality of cells of the erythroid lineage (HP:0012130)3.08526561
13Abnormality of serum amino acid levels (HP:0003112)3.04118388
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99093126
15Elevated erythrocyte sedimentation rate (HP:0003565)2.95994244
16Type 2 muscle fiber atrophy (HP:0003554)2.95928256
17Rhabdomyosarcoma (HP:0002859)2.91586533
18Meckel diverticulum (HP:0002245)2.91429246
19Thrombocytosis (HP:0001894)2.90253473
20True hermaphroditism (HP:0010459)2.90094005
21Optic neuritis (HP:0100653)2.86014310
22Retrobulbar optic neuritis (HP:0100654)2.86014310
23Abnormality of the ileum (HP:0001549)2.78049426
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.70925750
25IgM deficiency (HP:0002850)2.68145603
26Muscle fiber atrophy (HP:0100295)2.67419392
27Reduced antithrombin III activity (HP:0001976)2.67086561
28Petechiae (HP:0000967)2.65043829
29Abnormal protein glycosylation (HP:0012346)2.64312319
30Abnormal glycosylation (HP:0012345)2.64312319
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.64312319
32Abnormal protein N-linked glycosylation (HP:0012347)2.64312319
33Chromsome breakage (HP:0040012)2.62254419
3411 pairs of ribs (HP:0000878)2.61709322
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59797083
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59797083
37Progressive inability to walk (HP:0002505)2.58667601
38Hyperglycinemia (HP:0002154)2.56790330
39Nephroblastoma (Wilms tumor) (HP:0002667)2.54710083
40Papillary thyroid carcinoma (HP:0002895)2.53272101
41Pancreatic fibrosis (HP:0100732)2.48879536
42Methylmalonic acidemia (HP:0002912)2.48578829
43Embryonal renal neoplasm (HP:0011794)2.47775204
44Albinism (HP:0001022)2.46270294
453-Methylglutaconic aciduria (HP:0003535)2.45218974
46Premature graying of hair (HP:0002216)2.43558425
47Birth length less than 3rd percentile (HP:0003561)2.40463036
48Oral leukoplakia (HP:0002745)2.40417018
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39074268
50Orchitis (HP:0100796)2.37753781
51Poor head control (HP:0002421)2.37499466
52Hyperalaninemia (HP:0003348)2.37036060
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37036060
54Abnormality of alanine metabolism (HP:0010916)2.37036060
55Breast carcinoma (HP:0003002)2.36859748
56Irregular epiphyses (HP:0010582)2.36844275
57Abnormal rod and cone electroretinograms (HP:0008323)2.34890941
58Sloping forehead (HP:0000340)2.33455665
59Reticulocytopenia (HP:0001896)2.31481491
60Abnormality of the columella (HP:0009929)2.30505576
61Pancytopenia (HP:0001876)2.29106892
62Thyroiditis (HP:0100646)2.28442555
63Pancreatic islet-cell hyperplasia (HP:0004510)2.27139512
64Biliary tract neoplasm (HP:0100574)2.26795704
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24629760
66Gonadotropin excess (HP:0000837)2.24358426
67Duodenal stenosis (HP:0100867)2.22866734
68Small intestinal stenosis (HP:0012848)2.22866734
69Pancreatic cysts (HP:0001737)2.20988165
70Rough bone trabeculation (HP:0100670)2.20963311
71Increased serum lactate (HP:0002151)2.18976038
72Abnormality of methionine metabolism (HP:0010901)2.18900739
73Thyroid carcinoma (HP:0002890)2.17291078
74Abnormal hair whorl (HP:0010721)2.15893246
75Abnormality of serine family amino acid metabolism (HP:0010894)2.15650367
76Abnormality of glycine metabolism (HP:0010895)2.15650367
77Neoplasm of the adrenal gland (HP:0100631)2.14303915
78Renal Fanconi syndrome (HP:0001994)2.13603759
79Stenosis of the external auditory canal (HP:0000402)2.13210957
80Myelodysplasia (HP:0002863)2.11834566
81Recurrent abscess formation (HP:0002722)2.11378517
82Colon cancer (HP:0003003)2.11254435
83Patchy hypopigmentation of hair (HP:0011365)2.09384418
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09005888
85Lymphoma (HP:0002665)2.08129732
86Chronic otitis media (HP:0000389)2.07598770
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07389333
88Clubbing of toes (HP:0100760)2.07016419
89Absent epiphyses (HP:0010577)2.06922294
90Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.06922294
91Increased CSF lactate (HP:0002490)2.06847449
92Bone marrow hypocellularity (HP:0005528)2.06630409
93Amyotrophic lateral sclerosis (HP:0007354)2.04511574
94Medulloblastoma (HP:0002885)2.04475082
95Respiratory difficulties (HP:0002880)2.04073810
96Abnormality of the duodenum (HP:0002246)2.03819246
97Severe combined immunodeficiency (HP:0004430)2.01248623
98Prostate neoplasm (HP:0100787)2.01004821
99Neoplasm of the adrenal cortex (HP:0100641)1.99770988
100Abnormality of T cells (HP:0002843)1.99165187
101Mitochondrial inheritance (HP:0001427)1.98673364
102Hyperinsulinemic hypoglycemia (HP:0000825)1.98192362
103Exercise-induced muscle cramps (HP:0003710)1.98158270
104Neoplasm of the colon (HP:0100273)1.97070605
105Combined immunodeficiency (HP:0005387)1.96614683
106Partial agenesis of the corpus callosum (HP:0001338)1.96568720
107Recurrent pneumonia (HP:0006532)1.96458064
108Ependymoma (HP:0002888)1.96400730
109Short middle phalanx of the 5th finger (HP:0004220)1.95715365
110Prolonged neonatal jaundice (HP:0006579)1.94974456
111Ovarian neoplasm (HP:0100615)1.93708511
112Pallor (HP:0000980)1.93421127
113Abnormality of midbrain morphology (HP:0002418)1.92983143
114Molar tooth sign on MRI (HP:0002419)1.92983143
115Hypothermia (HP:0002045)1.91821853
116Encephalitis (HP:0002383)1.91695174
117Fair hair (HP:0002286)1.91032431
118IgG deficiency (HP:0004315)1.90231711
119Abolished electroretinogram (ERG) (HP:0000550)1.90195662
120Metaphyseal dysplasia (HP:0100255)1.90137263
121Autoimmune hemolytic anemia (HP:0001890)1.89735297
122Glioma (HP:0009733)1.89123786
123Volvulus (HP:0002580)1.88521908
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.88389753
125Abnormality of the labia minora (HP:0012880)1.87853952
126Intestinal atresia (HP:0011100)1.87732527
127Abnormality of eosinophils (HP:0001879)1.87393334
128Pulmonary fibrosis (HP:0002206)1.87367189
129Hepatocellular necrosis (HP:0001404)1.86867923
130Septo-optic dysplasia (HP:0100842)1.86705155
131Hyperglycinuria (HP:0003108)1.86422625
132Increased hepatocellular lipid droplets (HP:0006565)1.85716999
133Eosinophilia (HP:0001880)1.85374913
134Abnormality of the pons (HP:0007361)1.84795235
135White forelock (HP:0002211)1.83669670
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81687878
137Triphalangeal thumb (HP:0001199)1.81056133
138Abnormality of T cell physiology (HP:0011840)1.81037905
139Cellular immunodeficiency (HP:0005374)1.80685465
140Curly hair (HP:0002212)1.80297453
141Mediastinal lymphadenopathy (HP:0100721)1.79937273
142Neutropenia (HP:0001875)1.79263698
143Uterine neoplasm (HP:0010784)1.78212068
144Hypoplasia of the fovea (HP:0007750)1.78159378
145Aplasia/Hypoplasia of the fovea (HP:0008060)1.78159378
146Agnosia (HP:0010524)1.77865786
147Lipid accumulation in hepatocytes (HP:0006561)1.77524702
148Prolonged bleeding time (HP:0003010)1.76949019
149Prolonged partial thromboplastin time (HP:0003645)1.76816709
150Methylmalonic aciduria (HP:0012120)1.76353381
151Keratoconjunctivitis sicca (HP:0001097)1.76346100
152Median cleft lip (HP:0000161)1.75912517
153Chronic hepatic failure (HP:0100626)1.75789176
154Fibular aplasia (HP:0002990)1.75629735
155Exertional dyspnea (HP:0002875)1.75283511
156B lymphocytopenia (HP:0010976)1.74919642
157Abnormality of B cell number (HP:0010975)1.74919642
158Abnormality of the preputium (HP:0100587)1.74832544
159Bifid tongue (HP:0010297)1.74002266
160Aplasia/hypoplasia of the uterus (HP:0008684)1.73807245
161Optic nerve coloboma (HP:0000588)1.73759789
162Abnormal lung lobation (HP:0002101)1.73236471
163Abnormal spermatogenesis (HP:0008669)1.73019413
164Increased IgM level (HP:0003496)1.72959887
165Neoplasm of the small intestine (HP:0100833)1.71889827
166Lactic acidosis (HP:0003128)1.70955199
167Abnormality of the metopic suture (HP:0005556)1.69289504
168Abnormal trabecular bone morphology (HP:0100671)1.69100484
169Abnormal biliary tract morphology (HP:0012440)1.69075349
170Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68595860
171Lymphopenia (HP:0001888)1.68017367
172Hepatic necrosis (HP:0002605)1.67965072
173Weak cry (HP:0001612)1.66414100
174Nephronophthisis (HP:0000090)1.64494764
175Prominent metopic ridge (HP:0005487)1.62283130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.21977727
2TRIM283.12084277
3MAP4K22.99923015
4STK162.94417253
5MST42.84996487
6PIM22.72380173
7EIF2AK12.55741812
8WEE12.54098581
9TAF12.49349955
10VRK12.46581630
11CDC72.36327000
12MAP3K142.27839148
13NME22.11851816
14IRAK42.11828087
15FRK2.09589053
16IRAK32.07496740
17ACVR1B2.05235351
18EIF2AK31.99925037
19ZAK1.96113287
20MKNK11.94589049
21BUB11.93322812
22PLK41.90756111
23BCR1.87262636
24BMPR1B1.80642817
25TGFBR11.75852842
26TNIK1.73991706
27TXK1.71542740
28STK38L1.61249845
29STK31.60648514
30WNK31.60609257
31ERBB31.60282691
32TEC1.59305720
33CCNB11.58202297
34PASK1.54158668
35NEK11.54071111
36TTK1.52748894
37PBK1.51770556
38BRSK21.42580757
39SRPK11.41066492
40RPS6KB21.40966381
41KIT1.38042392
42JAK31.33245944
43ADRBK21.31859594
44FLT31.31770922
45EIF2AK21.30289137
46SIK31.29777114
47TAOK31.28294344
48MAPK131.28046234
49TSSK61.26986634
50ATR1.26798988
51BTK1.26671509
52TAOK21.26419007
53DYRK31.20708139
54PIM11.20464488
55CDK81.20045037
56CSNK1G11.19300244
57MUSK1.18573167
58MAP3K121.18505617
59NEK91.18429032
60VRK21.16665525
61NLK1.14850829
62IKBKB1.11306560
63BMPR21.09940166
64BRD41.06523610
65MKNK21.06075778
66CLK11.03951462
67RPS6KA41.01902322
68TRPM70.98812079
69MAP3K40.89779414
70MAP3K130.89194586
71MAP2K30.88308040
72TYK20.88003130
73DAPK10.87526923
74CDK60.86233435
75YES10.86114039
76CDK190.85970211
77MAPKAPK50.85226069
78TBK10.85139417
79CASK0.83308900
80CDK30.82506419
81PLK10.77858923
82CHUK0.76355014
83CDK70.76257474
84PRPF4B0.76094924
85CAMKK20.75821895
86SYK0.74632860
87LATS10.74555688
88MAPKAPK30.74222530
89AURKB0.73322291
90RAF10.72840380
91CSNK1G30.71794843
92STK100.70781722
93PLK30.70545731
94PLK20.70535073
95MELK0.70215679
96MYLK0.70002573
97STK240.69827090
98MAP4K10.68897862
99OBSCN0.66766617
100BRAF0.66281362
101CSNK1G20.65750685
102EPHA30.65622238
103CSNK1A1L0.64026506
104LYN0.63401333
105NEK20.63036000
106ZAP700.62692852
107TIE10.62448297
108ATM0.61076488
109PINK10.59728703
110BLK0.59638160
111IKBKE0.59635796
112CSF1R0.57723923
113TESK20.56194015
114SCYL20.56167524
115SGK20.55665751
116PIK3CA0.55358753
117CSNK2A10.54859689
118AKT30.54014546
119MAP2K70.53458057
120WNK40.53029176
121CHEK20.51975935
122MATK0.51492173
123RPS6KB10.51331486
124GRK10.51227412
125BRSK10.49154083
126STK390.48330699
127DYRK20.46378454
128JAK10.46285636
129BCKDK0.46049901
130PRKCE0.45137926
131MAP3K30.43968698
132ITK0.43894273
133MAP3K50.43604415
134FGFR10.42922729
135EGFR0.42192532
136AURKA0.41732107
137RPS6KA50.41528682
138PRKCD0.40144005
139PRKCQ0.39165221
140TNK20.38649467
141FER0.34667884
142PIK3CG0.33423103
143ERBB40.32406847
144FGFR30.30687835
145STK40.30144997
146LCK0.29390163
147ALK0.26504947
148IGF1R0.26217235

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44680424
2Mismatch repair_Homo sapiens_hsa034303.72693020
3Proteasome_Homo sapiens_hsa030503.37691245
4Base excision repair_Homo sapiens_hsa034103.00502582
5Ribosome_Homo sapiens_hsa030102.94911314
6RNA polymerase_Homo sapiens_hsa030202.93881367
7Homologous recombination_Homo sapiens_hsa034402.72465355
8Pyrimidine metabolism_Homo sapiens_hsa002402.72074508
9Protein export_Homo sapiens_hsa030602.57460224
10Propanoate metabolism_Homo sapiens_hsa006402.54448120
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.49297401
12Spliceosome_Homo sapiens_hsa030402.46649195
13Nucleotide excision repair_Homo sapiens_hsa034202.45782639
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41407793
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.38759716
16Non-homologous end-joining_Homo sapiens_hsa034502.25695038
17Steroid biosynthesis_Homo sapiens_hsa001002.15019573
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08441328
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05640290
20RNA degradation_Homo sapiens_hsa030181.95075935
21Selenocompound metabolism_Homo sapiens_hsa004501.93381087
22Fanconi anemia pathway_Homo sapiens_hsa034601.92457805
23Basal transcription factors_Homo sapiens_hsa030221.85172481
24Cell cycle_Homo sapiens_hsa041101.84125249
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70322463
26Purine metabolism_Homo sapiens_hsa002301.68276960
27RNA transport_Homo sapiens_hsa030131.67191393
28Legionellosis_Homo sapiens_hsa051341.54624546
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46259929
30One carbon pool by folate_Homo sapiens_hsa006701.41181993
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.36336615
32Herpes simplex infection_Homo sapiens_hsa051681.34824483
33Allograft rejection_Homo sapiens_hsa053301.34665340
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33396338
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31266243
36Fatty acid elongation_Homo sapiens_hsa000621.29972204
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26879353
38Sulfur metabolism_Homo sapiens_hsa009201.20781908
39Peroxisome_Homo sapiens_hsa041461.20028070
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18727176
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.16753920
42Caffeine metabolism_Homo sapiens_hsa002321.15285396
43p53 signaling pathway_Homo sapiens_hsa041151.13076763
44Primary immunodeficiency_Homo sapiens_hsa053401.12794447
45Other glycan degradation_Homo sapiens_hsa005111.11357327
46Pyruvate metabolism_Homo sapiens_hsa006201.07970235
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.04758486
48Leishmaniasis_Homo sapiens_hsa051401.04595994
49Measles_Homo sapiens_hsa051621.04435485
50Butanoate metabolism_Homo sapiens_hsa006501.03417042
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03198174
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02487004
53Epstein-Barr virus infection_Homo sapiens_hsa051690.99712307
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98829043
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97683215
56Graft-versus-host disease_Homo sapiens_hsa053320.97326833
57Autoimmune thyroid disease_Homo sapiens_hsa053200.95750835
58Parkinsons disease_Homo sapiens_hsa050120.95154114
59Circadian rhythm_Homo sapiens_hsa047100.92815325
60Hematopoietic cell lineage_Homo sapiens_hsa046400.90544923
61Oxidative phosphorylation_Homo sapiens_hsa001900.90218775
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87512092
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86771796
64N-Glycan biosynthesis_Homo sapiens_hsa005100.86655358
65Nitrogen metabolism_Homo sapiens_hsa009100.86445595
66Arachidonic acid metabolism_Homo sapiens_hsa005900.85448547
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82835422
68Type I diabetes mellitus_Homo sapiens_hsa049400.82487478
69Tryptophan metabolism_Homo sapiens_hsa003800.81985282
70Retinol metabolism_Homo sapiens_hsa008300.80677336
71Asthma_Homo sapiens_hsa053100.80188186
72Huntingtons disease_Homo sapiens_hsa050160.79847240
73Antigen processing and presentation_Homo sapiens_hsa046120.79360489
74Folate biosynthesis_Homo sapiens_hsa007900.75765965
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74187462
76Fatty acid degradation_Homo sapiens_hsa000710.71803913
77T cell receptor signaling pathway_Homo sapiens_hsa046600.69902940
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68184698
79Lysine degradation_Homo sapiens_hsa003100.63986586
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63229811
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62386481
82Oocyte meiosis_Homo sapiens_hsa041140.61429999
83Influenza A_Homo sapiens_hsa051640.60427765
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60179441
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59091103
86Pentose phosphate pathway_Homo sapiens_hsa000300.58732896
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57089058
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56996510
89Shigellosis_Homo sapiens_hsa051310.56664414
90TGF-beta signaling pathway_Homo sapiens_hsa043500.54193440
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.52987834
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51112096
93Hepatitis B_Homo sapiens_hsa051610.50731940
94mRNA surveillance pathway_Homo sapiens_hsa030150.48600284
95Systemic lupus erythematosus_Homo sapiens_hsa053220.48154341
96Thyroid cancer_Homo sapiens_hsa052160.47884815
97Colorectal cancer_Homo sapiens_hsa052100.46472095
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46278227
99Sphingolipid metabolism_Homo sapiens_hsa006000.46029426
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.45607321
101Pertussis_Homo sapiens_hsa051330.44514707
102Alzheimers disease_Homo sapiens_hsa050100.43991182
103ABC transporters_Homo sapiens_hsa020100.43441065
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43331675
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42570615
106Viral carcinogenesis_Homo sapiens_hsa052030.42206280
107Malaria_Homo sapiens_hsa051440.41317651
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41268012
109Rheumatoid arthritis_Homo sapiens_hsa053230.40866685
110HTLV-I infection_Homo sapiens_hsa051660.40358310
111Vitamin B6 metabolism_Homo sapiens_hsa007500.40337761
112Fatty acid metabolism_Homo sapiens_hsa012120.40058618
113Apoptosis_Homo sapiens_hsa042100.39959508
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39447954
115Regulation of autophagy_Homo sapiens_hsa041400.38381648
116Metabolic pathways_Homo sapiens_hsa011000.38371986
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37911922
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36655441
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36282579
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35361711
121Fructose and mannose metabolism_Homo sapiens_hsa000510.34987208
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.34558350
123beta-Alanine metabolism_Homo sapiens_hsa004100.34115403
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33676299
125FoxO signaling pathway_Homo sapiens_hsa040680.33363090
126Linoleic acid metabolism_Homo sapiens_hsa005910.32847409
127African trypanosomiasis_Homo sapiens_hsa051430.32128311
128Phagosome_Homo sapiens_hsa041450.30943856
129Carbon metabolism_Homo sapiens_hsa012000.30719409
130Wnt signaling pathway_Homo sapiens_hsa043100.29694210
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28880144
132Prostate cancer_Homo sapiens_hsa052150.28380555
133Renin-angiotensin system_Homo sapiens_hsa046140.28325057
134Tuberculosis_Homo sapiens_hsa051520.27835684
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27531355
136Salmonella infection_Homo sapiens_hsa051320.27404121
137Galactose metabolism_Homo sapiens_hsa000520.27104715
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26566366
139Adherens junction_Homo sapiens_hsa045200.25704808
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24624341
141Chemical carcinogenesis_Homo sapiens_hsa052040.24063318
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23462641
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23428226
144Small cell lung cancer_Homo sapiens_hsa052220.23321658
145Phototransduction_Homo sapiens_hsa047440.21485697
146Toxoplasmosis_Homo sapiens_hsa051450.21459097
147B cell receptor signaling pathway_Homo sapiens_hsa046620.21335656
148Biosynthesis of amino acids_Homo sapiens_hsa012300.20888004

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