STYXL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.67430268
2binding of sperm to zona pellucida (GO:0007339)9.63952802
3plasma membrane fusion (GO:0045026)9.63133719
4motile cilium assembly (GO:0044458)9.46597698
5reproduction (GO:0000003)9.15900044
6spermatid development (GO:0007286)8.14008611
7piRNA metabolic process (GO:0034587)7.98594898
8single fertilization (GO:0007338)7.50566764
9male meiosis (GO:0007140)7.48827192
10regulation of cilium movement (GO:0003352)7.06759857
11sperm capacitation (GO:0048240)6.86251586
12synaptonemal complex organization (GO:0070193)6.38065041
13negative regulation of inclusion body assembly (GO:0090084)6.17704263
14fertilization (GO:0009566)6.12455960
15ventricular system development (GO:0021591)6.05721895
16synaptonemal complex assembly (GO:0007130)6.01817084
17proteasome assembly (GO:0043248)5.84577925
18spermatogenesis (GO:0007283)5.59135629
19male gamete generation (GO:0048232)5.56770943
20organic cation transport (GO:0015695)5.31845570
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.26862253
22axoneme assembly (GO:0035082)5.21965542
23DNA methylation involved in gamete generation (GO:0043046)5.16226263
24gamete generation (GO:0007276)5.13313289
25regulation of inclusion body assembly (GO:0090083)5.09956094
26calcium ion-dependent exocytosis (GO:0017156)5.07164047
27establishment of protein localization to mitochondrial membrane (GO:0090151)5.03535907
28microtubule depolymerization (GO:0007019)4.85683016
29cell recognition (GO:0008037)4.82961402
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.82644228
31male meiosis I (GO:0007141)4.80912203
32regulation of cellular amino acid metabolic process (GO:0006521)4.77619236
33microtubule severing (GO:0051013)4.73440224
34spermatid nucleus differentiation (GO:0007289)4.65375549
35intraciliary transport (GO:0042073)4.58194531
36cellular process involved in reproduction in multicellular organism (GO:0022412)4.56486085
37germ cell development (GO:0007281)4.49735975
38ATP synthesis coupled proton transport (GO:0015986)4.47494721
39energy coupled proton transport, down electrochemical gradient (GO:0015985)4.47494721
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.46490708
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.40628755
42negative regulation of ligase activity (GO:0051352)4.40628755
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.35997039
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.32495510
45protein complex biogenesis (GO:0070271)4.23987359
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.23516007
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.23516007
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.22954397
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.22954397
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.22954397
51chromosome organization involved in meiosis (GO:0070192)4.14576227
52protein localization to cilium (GO:0061512)4.14445146
53regulation of mitochondrial translation (GO:0070129)4.14082473
54nucleoside diphosphate phosphorylation (GO:0006165)4.11971473
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07492525
56cilium organization (GO:0044782)4.07008918
57signal transduction involved in DNA integrity checkpoint (GO:0072401)4.06545209
58signal transduction involved in DNA damage checkpoint (GO:0072422)4.06545209
59meiotic nuclear division (GO:0007126)4.05261309
60regulation of microtubule-based movement (GO:0060632)4.03216961
61signal transduction involved in cell cycle checkpoint (GO:0072395)4.02313044
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.00832670
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.00361066
64deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.00101000
65mitochondrial respiratory chain complex assembly (GO:0033108)3.99444064
66multicellular organismal reproductive process (GO:0048609)3.98702133
67respiratory electron transport chain (GO:0022904)3.96636293
68electron transport chain (GO:0022900)3.91099673
69chaperone-mediated protein transport (GO:0072321)3.89313756
70cilium assembly (GO:0042384)3.88425839
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.88415432
72protein neddylation (GO:0045116)3.85849720
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.82408314
74meiotic cell cycle (GO:0051321)3.81329579
75centriole assembly (GO:0098534)3.77686159
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.77314048
77NADH dehydrogenase complex assembly (GO:0010257)3.77314048
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.77314048
79cilium morphogenesis (GO:0060271)3.75326507
80left/right pattern formation (GO:0060972)3.71499999
81rRNA modification (GO:0000154)3.70509673
82cullin deneddylation (GO:0010388)3.69623147
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.69262877
84cellular component assembly involved in morphogenesis (GO:0010927)3.67761663
85positive regulation of ligase activity (GO:0051351)3.67668746
86meiosis I (GO:0007127)3.66258322
87protein deneddylation (GO:0000338)3.65503339
88centriole replication (GO:0007099)3.63455180
89seminiferous tubule development (GO:0072520)3.58375049
90protein polyglutamylation (GO:0018095)3.55880749
91mannosylation (GO:0097502)3.55224399
92regulation of cellular amine metabolic process (GO:0033238)3.54329057
93microtubule-based movement (GO:0007018)3.54296367
94pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.52557862
95establishment of integrated proviral latency (GO:0075713)3.48626172
96GTP biosynthetic process (GO:0006183)3.45821115
97chaperone-mediated protein complex assembly (GO:0051131)3.40413128
98respiratory chain complex IV assembly (GO:0008535)3.39223470
99establishment of viral latency (GO:0019043)3.38452718
100cytochrome complex assembly (GO:0017004)3.36939921
101protein K11-linked deubiquitination (GO:0035871)3.33786384
102pyrimidine nucleotide catabolic process (GO:0006244)3.33011795
103monoubiquitinated protein deubiquitination (GO:0035520)3.32592633
104regulation of ubiquitin-protein transferase activity (GO:0051438)3.31751107
105protein targeting to mitochondrion (GO:0006626)3.30021475
106glycerol ether metabolic process (GO:0006662)3.27001255
107DNA deamination (GO:0045006)3.25621423
108protein maturation by protein folding (GO:0022417)3.24663180
109DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.24479665
110regulation of ligase activity (GO:0051340)3.21582746
111positive regulation of cell cycle arrest (GO:0071158)3.21401197
112establishment of protein localization to mitochondrion (GO:0072655)3.19083857
113negative regulation of protein ubiquitination (GO:0031397)3.18750961
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18553175
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18553175
116sequestering of actin monomers (GO:0042989)3.15861503
117microtubule polymerization or depolymerization (GO:0031109)3.10650908
118protein localization to mitochondrion (GO:0070585)3.10576546
119multicellular organismal development (GO:0007275)3.06895154
120metallo-sulfur cluster assembly (GO:0031163)3.06362825
121iron-sulfur cluster assembly (GO:0016226)3.06362825
122guanosine-containing compound biosynthetic process (GO:1901070)3.04647272
123negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.03989189
124deoxyribonucleotide catabolic process (GO:0009264)3.02726844
125base-excision repair, AP site formation (GO:0006285)3.02037270
126single strand break repair (GO:0000012)3.02029448
127ether metabolic process (GO:0018904)3.01152057
128oxidative phosphorylation (GO:0006119)3.00409548
129C-terminal protein lipidation (GO:0006501)3.00328221
130deoxyribose phosphate catabolic process (GO:0046386)2.98639053
131deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.96907899
132rRNA methylation (GO:0031167)2.96717763
133UTP biosynthetic process (GO:0006228)2.93773026
134antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.91671087
135genitalia morphogenesis (GO:0035112)2.89667488
136purine nucleobase biosynthetic process (GO:0009113)2.88111746
137ribosomal small subunit assembly (GO:0000028)2.86670294
138nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86351109
139branched-chain amino acid catabolic process (GO:0009083)2.86312607
140signal transduction in response to DNA damage (GO:0042770)2.84766327
141GMP metabolic process (GO:0046037)2.82322028
142hydrogen peroxide catabolic process (GO:0042744)2.81149935
143purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80217602
144pentose metabolic process (GO:0019321)2.77720185
145peptidyl-histidine modification (GO:0018202)2.77114604
146ubiquinone biosynthetic process (GO:0006744)2.76663875
147negative regulation of skeletal muscle tissue development (GO:0048642)2.75842928
148purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74477879
149exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73846191
150termination of RNA polymerase III transcription (GO:0006386)2.73054724
151transcription elongation from RNA polymerase III promoter (GO:0006385)2.73054724
1522-deoxyribonucleotide metabolic process (GO:0009394)2.71852258
153hydrogen ion transmembrane transport (GO:1902600)2.70925826
154inner mitochondrial membrane organization (GO:0007007)2.70735576
155regulation of cell cycle arrest (GO:0071156)2.70693804
156deoxyribose phosphate metabolic process (GO:0019692)2.70229260
157left/right axis specification (GO:0070986)2.68724652
158carnitine transport (GO:0015879)2.67116206
159amino-acid betaine transport (GO:0015838)2.67116206
160regulation of cytokine production involved in inflammatory response (GO:1900015)2.65754576
161pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65066865
162synapsis (GO:0007129)2.64701335
163UTP metabolic process (GO:0046051)2.63080424
164carnitine transmembrane transport (GO:1902603)2.62442400
165lactate metabolic process (GO:0006089)2.60880260
166protein refolding (GO:0042026)2.59171473
167peptidyl-glutamic acid modification (GO:0018200)2.59009802
168alditol metabolic process (GO:0019400)2.58368622
169deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.53945187
170sexual reproduction (GO:0019953)2.51608077
171microtubule bundle formation (GO:0001578)2.50924790
172glycerol metabolic process (GO:0006071)2.45492548
173chromosome condensation (GO:0030261)2.43332306
174cell projection assembly (GO:0030031)2.42123088
175calcium ion import (GO:0070509)2.38897359
176central nervous system myelination (GO:0022010)2.38110404
177axon ensheathment in central nervous system (GO:0032291)2.38110404
178regulation of spindle checkpoint (GO:0090231)2.36981478
179DNA packaging (GO:0006323)2.34805313
180meiotic cell cycle process (GO:1903046)2.33321178
181nonmotile primary cilium assembly (GO:0035058)2.32318843
182gene silencing by RNA (GO:0031047)2.27883368
183cilium or flagellum-dependent cell motility (GO:0001539)13.3692531
184fusion of sperm to egg plasma membrane (GO:0007342)12.6190215
185axonemal dynein complex assembly (GO:0070286)12.2888482
186cell wall macromolecule catabolic process (GO:0016998)12.1642100
187cell wall macromolecule metabolic process (GO:0044036)12.1642100
188sperm motility (GO:0030317)11.3299633
189multicellular organism reproduction (GO:0032504)11.0569774
190epithelial cilium movement (GO:0003351)11.0113216
191acrosome assembly (GO:0001675)10.9039401
192sperm-egg recognition (GO:0035036)10.8182011
193acrosome reaction (GO:0007340)10.6963272
194cilium movement (GO:0003341)10.4145345
195epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.0387356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.22849504
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.12417509
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.69485890
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.30681191
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.15069674
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.96148897
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.94373785
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43545738
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.37764315
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.35834851
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.24759431
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14022950
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10226475
14EZH2_22144423_ChIP-Seq_EOC_Human3.04081613
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.01769648
16MYC_18555785_ChIP-Seq_MESCs_Mouse3.00371979
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89522685
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85016618
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73074837
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.70993869
21* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61456997
22VDR_23849224_ChIP-Seq_CD4+_Human2.58494064
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.46200862
24ELK1_19687146_ChIP-ChIP_HELA_Human2.40265774
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.38893889
26* GABP_19822575_ChIP-Seq_HepG2_Human2.37621690
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.33554219
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.32377976
29DCP1A_22483619_ChIP-Seq_HELA_Human2.30448931
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27499738
31PCGF2_27294783_Chip-Seq_ESCs_Mouse2.27151992
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26872814
33MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24286214
34FOXP3_21729870_ChIP-Seq_TREG_Human2.23842984
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.22522688
36HOXB4_20404135_ChIP-ChIP_EML_Mouse2.17490293
37CBX2_27304074_Chip-Seq_ESCs_Mouse2.04598583
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03024817
39* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01265713
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.00023253
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99320444
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.95406690
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.92490539
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88260367
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86996906
46XRN2_22483619_ChIP-Seq_HELA_Human1.86253606
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84953573
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.84837684
49VDR_22108803_ChIP-Seq_LS180_Human1.84639397
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82837806
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82472289
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81419821
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.80908717
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80242550
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.79218872
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77074563
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74270876
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72962263
59TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.72549148
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.71654727
61KDM2B_26808549_Chip-Seq_REH_Human1.70586726
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69532766
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68816600
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67500219
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66127716
66KAP1_22055183_ChIP-Seq_ESCs_Mouse1.64617155
67TTF2_22483619_ChIP-Seq_HELA_Human1.64183058
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.62774304
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60960974
70STAT1_17558387_ChIP-Seq_HELA_Human1.59487128
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.59229172
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58150102
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.55570988
74ZNF274_21170338_ChIP-Seq_K562_Hela1.54560092
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54353830
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.51384778
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50067134
78ELK4_26923725_Chip-Seq_MESODERM_Mouse1.49997072
79OCT4_18555785_Chip-Seq_ESCs_Mouse1.49364600
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49204132
81P300_18555785_Chip-Seq_ESCs_Mouse1.48976303
82* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48872096
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.47956124
84P53_22387025_ChIP-Seq_ESCs_Mouse1.46186804
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46165797
86KDM5A_27292631_Chip-Seq_BREAST_Human1.45086792
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44678914
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.44624542
89KLF4_18555785_Chip-Seq_ESCs_Mouse1.44549873
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44462692
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44462692
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.43592356
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.43218548
94GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.42047108
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42034874
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.41386123
97RNF2_27304074_Chip-Seq_NSC_Mouse1.40938057
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39993919
99CBP_20019798_ChIP-Seq_JUKART_Human1.38713244
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38713244
101ELK1_22589737_ChIP-Seq_MCF10A_Human1.38171299
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37924635
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36930269
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35695292
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35280376
106ESRRB_18555785_Chip-Seq_ESCs_Mouse1.34431077
107ER_23166858_ChIP-Seq_MCF-7_Human1.32614758
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31775917
109RUNX1_27457419_Chip-Seq_LIVER_Mouse1.31191167
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.30942475
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30877514
112GATA3_21867929_ChIP-Seq_CD8_Mouse1.29759854
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29628065
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.28852771
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28711475
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27616235
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26825592
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26646962
119PU1_27457419_Chip-Seq_LIVER_Mouse1.26306342
120ZFX_18555785_Chip-Seq_ESCs_Mouse1.25586201
121MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24996785
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24102407
123WDR5_24793694_ChIP-Seq_LNCAP_Human1.23946375
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23222858
125GATA3_21867929_ChIP-Seq_TH1_Mouse1.21682814
126CTCF_18555785_Chip-Seq_ESCs_Mouse1.21519713
127SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21158008
128SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21103656
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20766836
130E2F7_22180533_ChIP-Seq_HELA_Human1.20672407
131LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20521373
132NMYC_18555785_Chip-Seq_ESCs_Mouse1.20343811
133CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18898914
134CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18514940
135ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18217568
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16689567
137TAF15_26573619_Chip-Seq_HEK293_Human1.15162892
138* REST_21632747_ChIP-Seq_MESCs_Mouse1.13954603
139MYC_18940864_ChIP-ChIP_HL60_Human1.13884918
140TFEB_21752829_ChIP-Seq_HELA_Human1.13347322
141* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12591900
142GF1_26923725_Chip-Seq_HPCs_Mouse1.10773285
143IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10369259
144ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10131724
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09662281
146SMAD4_21799915_ChIP-Seq_A2780_Human1.09047870
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08849455
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07387033
149P53_21459846_ChIP-Seq_SAOS-2_Human1.06183951
150PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05248008
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04957736
152FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04727612
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04059376
154POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03924152
155E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03552344
156TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03331489
157RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02053877
158ZNF263_19887448_ChIP-Seq_K562_Human1.01194415
159TCF4_23295773_ChIP-Seq_U87_Human1.00099768
160SPI1_23547873_ChIP-Seq_NB4_Human1.00000057
161NFYB_21822215_ChIP-Seq_K562_Human0.99087351
162* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98710632
163SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98554708
164* ELF5_23300383_ChIP-Seq_T47D_Human0.98148587
165ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97617672
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96573948
167CIITA_25753668_ChIP-Seq_RAJI_Human0.96490835
168CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95844382
169CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95441358
170EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95087880
171EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94642046
172* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94011650
173UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94009753
174SMAD3_21741376_ChIP-Seq_EPCs_Human0.93883425
175CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93835314
176YY1_22570637_ChIP-Seq_MALME-3M_Human0.93350564
177GF1B_26923725_Chip-Seq_HPCs_Mouse0.93237655
178P300_19829295_ChIP-Seq_ESCs_Human0.92235012
179SMAD4_21741376_ChIP-Seq_EPCs_Human0.91808498
180FOXP1_21924763_ChIP-Seq_HESCs_Human0.90757300
181TBL1_22424771_ChIP-Seq_293T_Human0.90600052
182HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90088681
183STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90012900
184PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87693095
185ESET_19884257_ChIP-Seq_ESCs_Mouse0.87312968
186RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85349834
187PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84801707
188GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84656665
189ELF1_20517297_ChIP-Seq_JURKAT_Human0.83499780
190NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83101526
191ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81999329
192* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81840399
193* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80021685
194BCL6_27268052_Chip-Seq_Bcells_Human0.76139922
195E2F1_21310950_ChIP-Seq_MCF-7_Human0.75086419
196MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.74320219
197CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74307045
198ERG_20517297_ChIP-Seq_VCAP_Human0.73187045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.87375373
2MP0003698_abnormal_male_reproductive5.48075100
3MP0001929_abnormal_gametogenesis4.91364190
4MP0008877_abnormal_DNA_methylation3.88100212
5MP0002653_abnormal_ependyma_morphology3.67373291
6MP0003186_abnormal_redox_activity3.35400444
7MP0002210_abnormal_sex_determination3.14113056
8MP0005623_abnormal_meninges_morphology2.85815957
9MP0002161_abnormal_fertility/fecundity2.85651293
10MP0006036_abnormal_mitochondrial_physio2.62704480
11MP0001145_abnormal_male_reproductive2.62346946
12MP0003718_maternal_effect2.46872715
13MP0006035_abnormal_mitochondrial_morpho2.41874400
14MP0009046_muscle_twitch2.40581956
15MP0003786_premature_aging2.39165329
16MP0008875_abnormal_xenobiotic_pharmacok2.36987486
17MP0000653_abnormal_sex_gland2.32952170
18MP0003693_abnormal_embryo_hatching2.26165762
19MP0003136_yellow_coat_color2.11225413
20MP0005058_abnormal_lysosome_morphology2.03631144
21MP0010094_abnormal_chromosome_stability2.00945952
22MP0005410_abnormal_fertilization14.1498306
23MP0000358_abnormal_cell_content/1.95584512
24MP0003191_abnormal_cellular_cholesterol1.94527112
25MP0002148_abnormal_hypersensitivity_rea1.93200027
26MP0004957_abnormal_blastocyst_morpholog1.82266325
27MP0004147_increased_porphyrin_level1.81197904
28MP0003950_abnormal_plasma_membrane1.80998508
29MP0008789_abnormal_olfactory_epithelium1.77467455
30MP0002282_abnormal_trachea_morphology1.74113395
31MP0002277_abnormal_respiratory_mucosa1.72079625
32MP0008007_abnormal_cellular_replicative1.71340810
33MP0009840_abnormal_foam_cell1.65845772
34MP0005670_abnormal_white_adipose1.63725983
35MP0001727_abnormal_embryo_implantation1.62078457
36MP0008932_abnormal_embryonic_tissue1.59725342
37MP0003646_muscle_fatigue1.56908115
38MP0005084_abnormal_gallbladder_morpholo1.53773894
39MP0001984_abnormal_olfaction1.51195244
40MP0003011_delayed_dark_adaptation1.46716203
41MP0003077_abnormal_cell_cycle1.42560092
42MP0005551_abnormal_eye_electrophysiolog1.40582455
43MP0002163_abnormal_gland_morphology1.39071279
44MP0001853_heart_inflammation1.39050883
45MP0008260_abnormal_autophagy1.37859083
46MP0000343_altered_response_to1.34422380
47MP0005083_abnormal_biliary_tract1.33420414
48MP0009785_altered_susceptibility_to1.31279734
49MP0002837_dystrophic_cardiac_calcinosis1.29725155
50MP0005075_abnormal_melanosome_morpholog1.29385188
51MP0005464_abnormal_platelet_physiology1.28855448
52MP0005394_taste/olfaction_phenotype1.25128157
53MP0005499_abnormal_olfactory_system1.25128157
54MP0000920_abnormal_myelination1.24422593
55MP0006082_CNS_inflammation1.18731111
56MP0003111_abnormal_nucleus_morphology1.17649803
57MP0005408_hypopigmentation1.13550336
58MP0002160_abnormal_reproductive_system1.13104524
59MP0005379_endocrine/exocrine_gland_phen1.12988856
60MP0002254_reproductive_system_inflammat1.12600483
61MP0005332_abnormal_amino_acid1.12433133
62MP0006292_abnormal_olfactory_placode1.11618212
63MP0005165_increased_susceptibility_to1.11608549
64MP0009765_abnormal_xenobiotic_induced1.10204740
65MP0001986_abnormal_taste_sensitivity1.01058666
66MP0000516_abnormal_urinary_system0.99694616
67MP0005367_renal/urinary_system_phenotyp0.99694616
68MP0001881_abnormal_mammary_gland0.99581734
69MP0003329_amyloid_beta_deposits0.99157917
70MP0009764_decreased_sensitivity_to0.98667182
71MP0009333_abnormal_splenocyte_physiolog0.96042732
72MP0001835_abnormal_antigen_presentation0.96002574
73MP0005377_hearing/vestibular/ear_phenot0.95883387
74MP0003878_abnormal_ear_physiology0.95883387
75MP0004233_abnormal_muscle_weight0.95787193
76MP0000313_abnormal_cell_death0.95616534
77MP0005584_abnormal_enzyme/coenzyme_acti0.94958299
78MP0002132_abnormal_respiratory_system0.94854980
79MP0003195_calcinosis0.94551155
80MP0008469_abnormal_protein_level0.93590138
81MP0002102_abnormal_ear_morphology0.93583755
82MP0005451_abnormal_body_composition0.93376917
83MP0003315_abnormal_perineum_morphology0.93212380
84MP0001765_abnormal_ion_homeostasis0.92986234
85MP0005671_abnormal_response_to0.91500124
86MP0001348_abnormal_lacrimal_gland0.90535863
87MP0005646_abnormal_pituitary_gland0.90511922
88MP0009763_increased_sensitivity_to0.89577557
89MP0005025_abnormal_response_to0.88240886
90MP0005319_abnormal_enzyme/_coenzyme0.86211006
91MP0004134_abnormal_chest_morphology0.84594973
92MP0002090_abnormal_vision0.84201527
93MP0008873_increased_physiological_sensi0.83546994
94MP0001845_abnormal_inflammatory_respons0.82971313
95MP0005395_other_phenotype0.82166719
96MP0002019_abnormal_tumor_incidence0.81913242
97MP0002139_abnormal_hepatobiliary_system0.81548532
98MP0005253_abnormal_eye_physiology0.81337509
99MP0003123_paternal_imprinting0.80854046
100MP0005423_abnormal_somatic_nervous0.80780257
101MP0008872_abnormal_physiological_respon0.80033032
102MP0002736_abnormal_nociception_after0.78572250
103MP0009379_abnormal_foot_pigmentation0.78552271
104MP0002938_white_spotting0.77211008
105MP0001545_abnormal_hematopoietic_system0.76267741
106MP0005397_hematopoietic_system_phenotyp0.76267741
107MP0005266_abnormal_metabolism0.75232720
108MP0003690_abnormal_glial_cell0.73636557
109MP0000490_abnormal_crypts_of0.73537924
110MP0003121_genomic_imprinting0.72790092
111MP0001542_abnormal_bone_strength0.72326832
112MP0002876_abnormal_thyroid_physiology0.72281903
113MP0003183_abnormal_peptide_metabolism0.71322256
114MP0001905_abnormal_dopamine_level0.68937085
115MP0003656_abnormal_erythrocyte_physiolo0.66495203
116MP0009250_abnormal_appendicular_skeleto0.66071828
117MP0008058_abnormal_DNA_repair0.65738933
118MP0001851_eye_inflammation0.65101988
119MP0001486_abnormal_startle_reflex0.64369912
120MP0003279_aneurysm0.64109613
121MP0003634_abnormal_glial_cell0.60824279
122MP0005636_abnormal_mineral_homeostasis0.60248302
123MP0002971_abnormal_brown_adipose0.59163533
124MP0004019_abnormal_vitamin_homeostasis0.58949119
125MP0003633_abnormal_nervous_system0.57655964
126MP0004381_abnormal_hair_follicle0.57466753
127MP0000427_abnormal_hair_cycle0.56588201
128MP0001324_abnormal_eye_pigmentation0.55877234
129MP0005195_abnormal_posterior_eye0.55781334
130MP0004133_heterotaxia0.55048463
131MP0005647_abnormal_sex_gland0.53110797
132MP0001346_abnormal_lacrimal_gland0.52642682
133MP0008057_abnormal_DNA_replication0.52508755
134MP0005645_abnormal_hypothalamus_physiol0.51835493
135MP0002234_abnormal_pharynx_morphology0.51208408
136MP0005409_darkened_coat_color0.49878873
137MP0000631_abnormal_neuroendocrine_gland0.49423791
138MP0003631_nervous_system_phenotype0.49043589
139MP0002928_abnormal_bile_duct0.47519307
140MP0002405_respiratory_system_inflammati0.47154352
141MP0006072_abnormal_retinal_apoptosis0.46773423
142MP0001270_distended_abdomen0.45956294
143MP0008995_early_reproductive_senescence0.45780293
144MP0004270_analgesia0.45403257
145MP0001764_abnormal_homeostasis0.45189088
146MP0009697_abnormal_copulation0.44669528
147MP0003724_increased_susceptibility_to0.44431277
148MP0002272_abnormal_nervous_system0.43923856
149MP0002064_seizures0.43891149
150MP0000604_amyloidosis0.42959319
151MP0002229_neurodegeneration0.42802853
152MP0004742_abnormal_vestibular_system0.42453615
153MP0001963_abnormal_hearing_physiology0.41773538
154MP0000647_abnormal_sebaceous_gland0.39948169
155MP0005391_vision/eye_phenotype0.39898777
156MP0002133_abnormal_respiratory_system0.39845076
157MP0005388_respiratory_system_phenotype0.39845076
158MP0002572_abnormal_emotion/affect_behav0.39320795
159MP0002752_abnormal_somatic_nervous0.37114193
160MP0002734_abnormal_mechanical_nocicepti0.37028257
161MP0000372_irregular_coat_pigmentation0.36910333
162MP0001968_abnormal_touch/_nociception0.36906933
163MP0000026_abnormal_inner_ear0.36503456
164MP0001529_abnormal_vocalization0.35742130
165MP0000462_abnormal_digestive_system0.33934775
166MP0005389_reproductive_system_phenotype0.33686615
167MP0002933_joint_inflammation0.33229840
168MP0004142_abnormal_muscle_tone0.32716920
169MP0009115_abnormal_fat_cell0.32674987
170MP0000778_abnormal_nervous_system0.32352756
171MP0003699_abnormal_female_reproductive0.31666112
172MP0002152_abnormal_brain_morphology0.31052487
173MP0003632_abnormal_nervous_system0.30968738

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.69981963
2Abnormal respiratory epithelium morphology (HP:0012253)9.33943107
3Abnormal respiratory motile cilium morphology (HP:0005938)9.33943107
4Rhinitis (HP:0012384)8.55253156
5Chronic bronchitis (HP:0004469)6.08728953
6Nasal polyposis (HP:0100582)5.47022299
7Acute necrotizing encephalopathy (HP:0006965)5.15455896
8Infertility (HP:0000789)5.13319831
9Bronchiectasis (HP:0002110)4.99211594
10Mitochondrial inheritance (HP:0001427)4.88695580
11Abnormal mitochondria in muscle tissue (HP:0008316)4.84752669
12Acute encephalopathy (HP:0006846)4.70493975
13Hepatocellular necrosis (HP:0001404)4.57306044
14Abnormality of the nasal mucosa (HP:0000433)4.54439394
15Increased CSF lactate (HP:0002490)4.45915157
16Renal Fanconi syndrome (HP:0001994)4.34496440
17Hepatic necrosis (HP:0002605)4.27016872
18Progressive macrocephaly (HP:0004481)4.17483008
19Nephronophthisis (HP:0000090)4.02110191
20Bronchitis (HP:0012387)3.83844352
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.71059876
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.71059876
23Increased hepatocellular lipid droplets (HP:0006565)3.61900024
24Lipid accumulation in hepatocytes (HP:0006561)3.56329820
25Cerebral edema (HP:0002181)3.52368345
26Recurrent sinusitis (HP:0011108)3.48718014
27Medial flaring of the eyebrow (HP:0010747)3.40313857
28Type I transferrin isoform profile (HP:0003642)3.27338939
29Increased intramyocellular lipid droplets (HP:0012240)3.22238714
30Abnormality of the renal medulla (HP:0100957)3.18110770
31Lactic acidosis (HP:0003128)3.14140248
32Recurrent otitis media (HP:0000403)3.12955983
333-Methylglutaconic aciduria (HP:0003535)2.99400564
34Chronic sinusitis (HP:0011109)2.97930993
35Increased serum lactate (HP:0002151)2.92916869
36Respiratory failure (HP:0002878)2.87840595
37Increased muscle lipid content (HP:0009058)2.82950765
38Vacuolated lymphocytes (HP:0001922)2.79687133
39Abnormal protein glycosylation (HP:0012346)2.67204912
40Abnormal glycosylation (HP:0012345)2.67204912
41Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.67204912
42Abnormal protein N-linked glycosylation (HP:0012347)2.67204912
43Pancreatic fibrosis (HP:0100732)2.66434724
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65503315
45Exercise intolerance (HP:0003546)2.64689785
46Male infertility (HP:0003251)2.61439433
47Abnormality of midbrain morphology (HP:0002418)2.61170864
48Molar tooth sign on MRI (HP:0002419)2.61170864
49True hermaphroditism (HP:0010459)2.53247042
50Tubulointerstitial nephritis (HP:0001970)2.52781456
51Gait imbalance (HP:0002141)2.51821026
52Congenital primary aphakia (HP:0007707)2.49172318
53Optic disc pallor (HP:0000543)2.46657795
54Lethargy (HP:0001254)2.44615080
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43297141
56Exertional dyspnea (HP:0002875)2.42911559
57CNS demyelination (HP:0007305)2.38847137
58Reticulocytopenia (HP:0001896)2.38803587
59Generalized aminoaciduria (HP:0002909)2.38550909
60Respiratory difficulties (HP:0002880)2.37934271
61Abnormal spermatogenesis (HP:0008669)2.36535656
62Fibular hypoplasia (HP:0003038)2.35893693
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34142885
64Recurrent bronchitis (HP:0002837)2.33921286
65Aplastic anemia (HP:0001915)2.28746987
66Congenital hepatic fibrosis (HP:0002612)2.23942670
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22573541
68Emotional lability (HP:0000712)2.21995126
69Tubular atrophy (HP:0000092)2.21861643
70Postaxial foot polydactyly (HP:0001830)2.20357627
71Nephrogenic diabetes insipidus (HP:0009806)2.18142249
72Neurofibrillary tangles (HP:0002185)2.11806497
73Abnormality of dentin (HP:0010299)2.10009204
74Tubulointerstitial abnormality (HP:0001969)2.07983109
75Abnormality of permanent molar morphology (HP:0011071)2.06064950
76Abnormality of the dental root (HP:0006486)2.06064950
77Taurodontia (HP:0000679)2.06064950
78Leukodystrophy (HP:0002415)2.03664941
79Abnormality of liposaccharide metabolism (HP:0010968)2.01740252
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.01740252
81Abnormality of glycolipid metabolism (HP:0010969)2.01740252
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9003723
83Absent/shortened dynein arms (HP:0200106)11.2764824
84Dynein arm defect of respiratory motile cilia (HP:0012255)11.2764824
85Abnormal respiratory motile cilium physiology (HP:0012261)10.5249790
86Increased serum pyruvate (HP:0003542)1.99046024
87Pancreatic cysts (HP:0001737)1.98661837
88Poor coordination (HP:0002370)1.98201024
89Genital tract atresia (HP:0001827)1.97534032
90Pancytopenia (HP:0001876)1.97230911
91Abnormality of the dental pulp (HP:0006479)1.94483822
92Abnormality of molar (HP:0011077)1.94097066
93Abnormality of molar morphology (HP:0011070)1.94097066
94Reduced antithrombin III activity (HP:0001976)1.93267488
95Glycosuria (HP:0003076)1.92253686
96Abnormality of urine glucose concentration (HP:0011016)1.92253686
97Stage 5 chronic kidney disease (HP:0003774)1.91757119
98Supernumerary spleens (HP:0009799)1.89463084
99Aplasia/Hypoplasia of the lens (HP:0008063)1.89086372
100Vaginal atresia (HP:0000148)1.87760180
101Abnormality of glycolysis (HP:0004366)1.86573297
102Hepatosplenomegaly (HP:0001433)1.86377796
103Median cleft lip (HP:0000161)1.84733538
104Hyperglycinemia (HP:0002154)1.83990015
105Petechiae (HP:0000967)1.83657188
106Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83554922
107Dicarboxylic aciduria (HP:0003215)1.83554922
108Abnormality of the renal cortex (HP:0011035)1.83397272
109Rough bone trabeculation (HP:0100670)1.82243375
110Hyperphosphaturia (HP:0003109)1.81604476
111Occipital encephalocele (HP:0002085)1.81328758
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.80619780
113Postaxial hand polydactyly (HP:0001162)1.80521404
114Hypokinesia (HP:0002375)1.80003618
115Gonadotropin excess (HP:0000837)1.79105298
116Abnormality of the anterior horn cell (HP:0006802)1.78813383
117Degeneration of anterior horn cells (HP:0002398)1.78813383
118Nausea (HP:0002018)1.78236785
119Azoospermia (HP:0000027)1.78076483
120Cystic liver disease (HP:0006706)1.77519020
121Opisthotonus (HP:0002179)1.76503119
122Oral leukoplakia (HP:0002745)1.76048331
123Bell-shaped thorax (HP:0001591)1.75937009
124Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75005388
125Abnormal biliary tract physiology (HP:0012439)1.74895830
126Bile duct proliferation (HP:0001408)1.74895830
127Abnormal number of erythroid precursors (HP:0012131)1.73791084
128Death in infancy (HP:0001522)1.72457077
129X-linked dominant inheritance (HP:0001423)1.72023302
130Abnormal drinking behavior (HP:0030082)1.70043318
131Polydipsia (HP:0001959)1.70043318
132Decreased central vision (HP:0007663)1.68370370
133Severe visual impairment (HP:0001141)1.66984482
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.66705477
135Methylmalonic aciduria (HP:0012120)1.66507115
136Abnormality of fatty-acid metabolism (HP:0004359)1.64904821
137Vomiting (HP:0002013)1.64796972
138Sparse eyelashes (HP:0000653)1.64498186
139Abnormality of cells of the erythroid lineage (HP:0012130)1.62781111
140Neoplasm of the adrenal gland (HP:0100631)1.62412560
141Tubulointerstitial fibrosis (HP:0005576)1.61323982
142Optic nerve hypoplasia (HP:0000609)1.53981653
143Impulsivity (HP:0100710)1.52415503
144Absent epiphyses (HP:0010577)1.52075605
145Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52075605
146Short ribs (HP:0000773)1.48587344
147Oculomotor apraxia (HP:0000657)1.48541207
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.48169855
149Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.46853725
150Spastic tetraparesis (HP:0001285)1.46169090
151Short femoral neck (HP:0100864)1.45318201
152Renal dysplasia (HP:0000110)1.43531578
153Facial cleft (HP:0002006)1.42388259
154Short nail (HP:0001799)1.41172842
155Abnormality of renal excretion (HP:0011036)1.40294451
156Chronic hepatic failure (HP:0100626)1.40253713
157Cerebral inclusion bodies (HP:0100314)1.39973611
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.39071037
159Retinal dysplasia (HP:0007973)1.36998873
160Anencephaly (HP:0002323)1.36514970
161Short thorax (HP:0010306)1.36475629
162Abnormality of saccadic eye movements (HP:0000570)1.32965578
163Amyotrophic lateral sclerosis (HP:0007354)1.32398173
164Microglossia (HP:0000171)1.30381845
165Nephropathy (HP:0000112)1.29242869
166Absent frontal sinuses (HP:0002688)1.29179107
167Abnormality of renal resorption (HP:0011038)1.26232161
168Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.25882911
169Cholecystitis (HP:0001082)1.25490079
170Abnormal gallbladder physiology (HP:0012438)1.25490079
171Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.24729168
172Male pseudohermaphroditism (HP:0000037)1.21480493
173Astigmatism (HP:0000483)1.19739889
174Irregular epiphyses (HP:0010582)1.19149077
175Sclerocornea (HP:0000647)1.19120197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.86223223
2PDK47.86223223
3PDK25.02625152
4VRK24.60005564
5TESK14.31832930
6NME23.55700549
7STK393.41458252
8ICK3.35511220
9BCKDK3.10726646
10PRKD33.05304984
11MAP4K22.96471753
12MAP3K122.80435204
13MAPK152.70739570
14WNK42.68053132
15BUB12.54706564
16LIMK12.42024573
17TRIM282.41360040
18SRPK12.28689549
19PTK2B2.18127556
20PNCK2.07245470
21VRK11.87625588
22EPHA21.84121477
23MUSK1.83873634
24PIM21.83600723
25EIF2AK11.82494763
26EIF2AK31.65232865
27WNK11.48259503
28KDR1.38146914
29MAPKAPK31.35507118
30MST1R1.30633274
31NUAK11.29307137
32MAP3K111.28768243
33BCR1.28267126
34DYRK1B1.24309791
35SIK31.23744232
36STK381.18831342
37DAPK11.17956298
38NEK11.12114230
39SCYL21.02769423
40CSNK1G31.02230508
41ABL21.01093772
42TYRO31.00868647
43ARAF1.00491996
44TESK20.99308782
45PDK10.98336744
46TLK10.94921412
47PKN10.93553330
48IRAK10.93467380
49PLK30.92310261
50PLK40.92285758
51CDK190.91971142
52PAK40.91323435
53DYRK30.91023709
54DYRK20.90976273
55STK38L0.90575562
56TNIK0.90153764
57NEK60.89663376
58OXSR10.89595892
59MAPKAPK50.86731611
60PRPF4B0.86670782
61ERBB30.85257093
62MAP2K70.84021838
63NTRK20.83037291
64TAOK20.82229463
65IRAK30.81740509
66AURKA0.80171995
67PLK10.78054964
68EPHB10.77400307
69LMTK20.75987084
70LRRK20.73032903
71FGR0.71950447
72PRKCI0.68754419
73CSNK1G20.68418520
74STK30.68215676
75TSSK60.66954282
76MST40.66435789
77BMPR1B0.65510510
78CSNK1G10.65153318
79NEK20.63690084
80MAP2K60.63640229
81CSNK1A1L0.63618592
82GRK70.62676348
83FLT30.61818521
84STK100.60548375
85MATK0.60170789
86MAP3K50.59720770
87AURKB0.59205305
88DAPK30.58483776
89FGFR20.57674248
90PBK0.56607983
91PDPK10.56569096
92CDK30.55531626
93IKBKB0.54717085
94CDC70.53513029
95GRK10.52952301
96CSNK2A10.49323229
97BMPR20.46579911
98BRAF0.46111759
99CSNK2A20.45921226
100RPS6KA50.45752778
101TIE10.45021930
102BRSK20.44331453
103NME10.44207754
104PRKCQ0.43060455
105MYLK0.42843094
106TAF10.42089037
107CHEK20.40105228
108MAP3K80.36512517
109INSRR0.36442392
110ILK0.34476728
111YES10.34130471
112CDK80.33811602
113EIF2AK20.33445626
114WNK30.32775263
115BRSK10.30918041
116CSK0.30429617
117ERN10.30175345
118TBK10.28983536
119TEC0.28811731
120ITK0.27214820
121PIK3CG0.26198463
122FGFR40.26141642
123PRKCG0.26134624
124BMX0.24854397
125OBSCN0.24044576
126PASK0.22923941
127PRKG10.22888793
128TTK0.22846332
129RPS6KA40.22687225
130CAMK2G0.22656404
131CDK70.22254274
132STK160.21493349
133TXK0.21203329
134DYRK1A0.18390512
135PINK10.18061920
136ZAK0.17409976
137CDK150.17138527
138PAK10.17122627
139CDK140.17052724
140ADRBK20.16683952
141CCNB10.16665561
142PLK20.16211797
143NEK90.16060432
144WEE10.15734845
145CAMK2A0.15419670
146IKBKE0.14784146
147PRKCD0.14537319
148CDK180.13589030
149CDK11A0.12401299
150PRKACG0.11137359
151RPS6KB10.11065335
152PRKACA0.11010816
153MET0.10943839
154PRKCZ0.10455826
155CASK0.10396627
156PRKAA10.10093265
157SGK4940.10049376
158SGK2230.10049376
159CHEK10.09967796
160ROCK20.09424828
161MAP3K30.08461311
162MAPK40.08347411
163MARK20.08293110
164INSR0.07325302
165ATM0.06949625
166LCK0.06724832
167GSK3A0.06454697
168MAPK100.06236766
169ATR0.06119567
170EGFR0.06071867

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.36657301
2Vitamin B6 metabolism_Homo sapiens_hsa007504.97815980
3Pyruvate metabolism_Homo sapiens_hsa006203.40993078
4Propanoate metabolism_Homo sapiens_hsa006403.26960209
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.05759684
6Linoleic acid metabolism_Homo sapiens_hsa005913.04268925
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.94327451
8Basal transcription factors_Homo sapiens_hsa030222.81474517
9Fatty acid biosynthesis_Homo sapiens_hsa000612.70181577
10Ribosome_Homo sapiens_hsa030102.60176690
11Ether lipid metabolism_Homo sapiens_hsa005652.58759866
12Pentose phosphate pathway_Homo sapiens_hsa000302.36729671
13Mismatch repair_Homo sapiens_hsa034302.25027558
14RNA polymerase_Homo sapiens_hsa030202.19950364
15DNA replication_Homo sapiens_hsa030302.08211974
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.05197004
17Huntingtons disease_Homo sapiens_hsa050161.96822262
18Steroid biosynthesis_Homo sapiens_hsa001001.94373385
19Fatty acid elongation_Homo sapiens_hsa000621.89954570
20Homologous recombination_Homo sapiens_hsa034401.88521831
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.77788246
22Pyrimidine metabolism_Homo sapiens_hsa002401.77279591
23Sulfur metabolism_Homo sapiens_hsa009201.75022808
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71610978
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71277428
26Glycerolipid metabolism_Homo sapiens_hsa005611.68307825
27Selenocompound metabolism_Homo sapiens_hsa004501.66381547
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65262115
29Base excision repair_Homo sapiens_hsa034101.63655372
30PPAR signaling pathway_Homo sapiens_hsa033201.58925696
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58627780
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57611987
33Dorso-ventral axis formation_Homo sapiens_hsa043201.57307445
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53005633
35Nucleotide excision repair_Homo sapiens_hsa034201.52722969
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50357737
37Glucagon signaling pathway_Homo sapiens_hsa049221.49660527
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46806983
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44032139
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.43509246
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39963990
42Folate biosynthesis_Homo sapiens_hsa007901.39618015
43Arachidonic acid metabolism_Homo sapiens_hsa005901.39142565
44Fanconi anemia pathway_Homo sapiens_hsa034601.37237922
45Mineral absorption_Homo sapiens_hsa049781.35428362
46Cardiac muscle contraction_Homo sapiens_hsa042601.35224276
47Autoimmune thyroid disease_Homo sapiens_hsa053201.28986387
48Spliceosome_Homo sapiens_hsa030401.26949315
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21884246
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20843265
51Fatty acid metabolism_Homo sapiens_hsa012121.20784044
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19153094
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14263894
54Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10940629
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.10862756
56Glutathione metabolism_Homo sapiens_hsa004801.08203103
57Fatty acid degradation_Homo sapiens_hsa000711.04186363
58Histidine metabolism_Homo sapiens_hsa003401.02686842
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02588173
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01508829
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99541832
62Amphetamine addiction_Homo sapiens_hsa050310.97443822
63N-Glycan biosynthesis_Homo sapiens_hsa005100.97363893
64Sulfur relay system_Homo sapiens_hsa041220.96909923
65Non-homologous end-joining_Homo sapiens_hsa034500.95799995
66RNA transport_Homo sapiens_hsa030130.95692150
67Fat digestion and absorption_Homo sapiens_hsa049750.94908440
68Sphingolipid metabolism_Homo sapiens_hsa006000.94089561
69Carbon metabolism_Homo sapiens_hsa012000.93617891
70ABC transporters_Homo sapiens_hsa020100.90921563
71Chemical carcinogenesis_Homo sapiens_hsa052040.89211788
72Galactose metabolism_Homo sapiens_hsa000520.88108612
73Renin secretion_Homo sapiens_hsa049240.83581285
74RNA degradation_Homo sapiens_hsa030180.81815101
75Lysosome_Homo sapiens_hsa041420.81663779
76Purine metabolism_Homo sapiens_hsa002300.81006524
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80688688
78Graft-versus-host disease_Homo sapiens_hsa053320.79264864
79One carbon pool by folate_Homo sapiens_hsa006700.79134177
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.79096856
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.76745619
82Vibrio cholerae infection_Homo sapiens_hsa051100.76620202
83Fructose and mannose metabolism_Homo sapiens_hsa000510.73082332
84Rheumatoid arthritis_Homo sapiens_hsa053230.72415794
85Metabolic pathways_Homo sapiens_hsa011000.71021763
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70761124
87Oocyte meiosis_Homo sapiens_hsa041140.68987214
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68865830
89Retinol metabolism_Homo sapiens_hsa008300.68800454
90Tyrosine metabolism_Homo sapiens_hsa003500.68285089
91Allograft rejection_Homo sapiens_hsa053300.67585117
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65496122
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.65470051
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.65114241
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61012765
96Phenylalanine metabolism_Homo sapiens_hsa003600.59909566
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59064635
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58808183
99Legionellosis_Homo sapiens_hsa051340.58663822
100Primary immunodeficiency_Homo sapiens_hsa053400.58357106
101Calcium signaling pathway_Homo sapiens_hsa040200.57877739
102Renin-angiotensin system_Homo sapiens_hsa046140.57354242
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56914534
104beta-Alanine metabolism_Homo sapiens_hsa004100.54655538
105Asthma_Homo sapiens_hsa053100.54254790
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54201133
107Epstein-Barr virus infection_Homo sapiens_hsa051690.51604273
108Other glycan degradation_Homo sapiens_hsa005110.51222362
109Biosynthesis of amino acids_Homo sapiens_hsa012300.51052597
110Oxidative phosphorylation_Homo sapiens_hsa001900.50250886
111Peroxisome_Homo sapiens_hsa041460.46990722
112Taste transduction_Homo sapiens_hsa047420.46829258
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46446064
114p53 signaling pathway_Homo sapiens_hsa041150.45218001
115Regulation of autophagy_Homo sapiens_hsa041400.44998577
116Cocaine addiction_Homo sapiens_hsa050300.42751941
117Alzheimers disease_Homo sapiens_hsa050100.42454903
118Systemic lupus erythematosus_Homo sapiens_hsa053220.42119809
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39055412
120Protein digestion and absorption_Homo sapiens_hsa049740.38637189
121Tryptophan metabolism_Homo sapiens_hsa003800.37777563
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36945911
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.36648697
124Protein export_Homo sapiens_hsa030600.36044245
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35478503
126Malaria_Homo sapiens_hsa051440.35296969
127Butanoate metabolism_Homo sapiens_hsa006500.34857865
128Shigellosis_Homo sapiens_hsa051310.34756717
129Salmonella infection_Homo sapiens_hsa051320.34540991
130Insulin secretion_Homo sapiens_hsa049110.29070197
131Cell cycle_Homo sapiens_hsa041100.28759800
132Measles_Homo sapiens_hsa051620.28439623
133Antigen processing and presentation_Homo sapiens_hsa046120.25656979
134Hedgehog signaling pathway_Homo sapiens_hsa043400.25627994
135Collecting duct acid secretion_Homo sapiens_hsa049660.24129491
136Type I diabetes mellitus_Homo sapiens_hsa049400.22024886
137Arginine and proline metabolism_Homo sapiens_hsa003300.20884330
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20458372
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.20236922
140Parkinsons disease_Homo sapiens_hsa050120.19498990
141Vitamin digestion and absorption_Homo sapiens_hsa049770.18348271
142Circadian entrainment_Homo sapiens_hsa047130.17977448
143Thyroid hormone synthesis_Homo sapiens_hsa049180.15210826
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14976321
145Complement and coagulation cascades_Homo sapiens_hsa046100.14040321
146Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14000542
147Staphylococcus aureus infection_Homo sapiens_hsa051500.12686259
148cAMP signaling pathway_Homo sapiens_hsa040240.12613665
149Endocytosis_Homo sapiens_hsa041440.11766950
150Nicotine addiction_Homo sapiens_hsa050330.11706923

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