SUB1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopamine transport (GO:0015872)7.71826309
2substrate-independent telencephalic tangential migration (GO:0021826)6.50670079
3substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.50670079
4DNA deamination (GO:0045006)5.97139687
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.70235350
6regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)5.37363201
7regulation of dopamine uptake involved in synaptic transmission (GO:0051584)5.37363201
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.37139480
9ATP synthesis coupled proton transport (GO:0015986)5.37139480
10cytidine deamination (GO:0009972)4.91243155
11cytidine metabolic process (GO:0046087)4.91243155
12cytidine catabolic process (GO:0006216)4.91243155
13peristalsis (GO:0030432)4.77593314
14mating behavior (GO:0007617)4.74952493
15phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.65747624
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.63073226
17chaperone-mediated protein transport (GO:0072321)4.50191031
18catecholamine transport (GO:0051937)4.45659349
19cell proliferation in forebrain (GO:0021846)4.39919774
20monoamine transport (GO:0015844)4.39516790
21pyrimidine ribonucleoside catabolic process (GO:0046133)4.39387094
22positive regulation of protein homodimerization activity (GO:0090073)4.34655629
23maternal behavior (GO:0042711)4.26192740
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.20166747
25regulation of hypersensitivity (GO:0002883)4.10954203
26positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.10636360
27platelet dense granule organization (GO:0060155)4.03837097
28regulation of dopamine metabolic process (GO:0042053)4.02416356
29regulation of catecholamine metabolic process (GO:0042069)4.02416356
30lens fiber cell development (GO:0070307)3.97397941
31adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.94842875
32parental behavior (GO:0060746)3.93510033
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.91210113
34maturation of 5.8S rRNA (GO:0000460)3.91155283
35regulation of neurotransmitter uptake (GO:0051580)3.90019754
36transmission of nerve impulse (GO:0019226)3.87638758
37electron transport chain (GO:0022900)3.80970929
38respiratory electron transport chain (GO:0022904)3.78537864
39protein complex biogenesis (GO:0070271)3.74552883
40negative regulation of mast cell activation (GO:0033004)3.73292161
41negative regulation of oligodendrocyte differentiation (GO:0048715)3.52712004
42synaptic transmission, dopaminergic (GO:0001963)3.52320895
43prepulse inhibition (GO:0060134)3.45966070
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.43977090
45NADH dehydrogenase complex assembly (GO:0010257)3.43977090
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43977090
47adult walking behavior (GO:0007628)3.40503531
48dentate gyrus development (GO:0021542)3.37606188
49activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.36435725
50ribosomal small subunit assembly (GO:0000028)3.30312766
51mitochondrial respiratory chain complex assembly (GO:0033108)3.23040377
52regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.22652110
53regulation of synaptic transmission, dopaminergic (GO:0032225)3.22174174
54cerebellar granule cell differentiation (GO:0021707)3.22108542
55behavioral response to cocaine (GO:0048148)3.18721289
56striatum development (GO:0021756)3.18545255
57phasic smooth muscle contraction (GO:0014821)3.18226363
58negative regulation of heart rate (GO:0010459)3.17318749
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.12906177
60protein localization to cilium (GO:0061512)3.10964738
61positive regulation of synapse assembly (GO:0051965)3.09587757
62neuronal action potential (GO:0019228)3.09305123
63DNA demethylation (GO:0080111)3.09023716
64ribosomal large subunit biogenesis (GO:0042273)3.07372617
65positive regulation of mast cell activation involved in immune response (GO:0033008)3.05803891
66positive regulation of mast cell degranulation (GO:0043306)3.05803891
67hydrogen ion transmembrane transport (GO:1902600)3.04522617
68tryptophan catabolic process (GO:0006569)3.04022530
69indole-containing compound catabolic process (GO:0042436)3.04022530
70indolalkylamine catabolic process (GO:0046218)3.04022530
71regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.03523211
72GPI anchor biosynthetic process (GO:0006506)2.99135621
73ATP biosynthetic process (GO:0006754)2.98200962
74preassembly of GPI anchor in ER membrane (GO:0016254)2.97269261
75negative regulation of calcium ion transport into cytosol (GO:0010523)2.87071761
76protein-cofactor linkage (GO:0018065)2.83058217
77positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.82585695
78proton transport (GO:0015992)2.80765743
79respiratory chain complex IV assembly (GO:0008535)2.80424288
80neuron fate determination (GO:0048664)2.79239753
81GPI anchor metabolic process (GO:0006505)2.78677740
82hydrogen transport (GO:0006818)2.73237351
83axonemal dynein complex assembly (GO:0070286)2.72852123
84positive regulation of mast cell activation (GO:0033005)2.70785240
85sequestering of actin monomers (GO:0042989)2.68515678
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65505177
87anterograde synaptic vesicle transport (GO:0048490)2.62561502
88neuronal action potential propagation (GO:0019227)2.60796537
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60363143
90grooming behavior (GO:0007625)2.58406851
91behavioral response to nicotine (GO:0035095)2.57445611
92response to amphetamine (GO:0001975)2.57124103
93galactose catabolic process (GO:0019388)2.56200752
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55017928
95auditory receptor cell stereocilium organization (GO:0060088)2.48809880
96centriole replication (GO:0007099)2.48619783
97somatic stem cell division (GO:0048103)2.44900133
98immunoglobulin mediated immune response (GO:0016064)2.44259792
99cytochrome complex assembly (GO:0017004)2.42322495
100protein polyglutamylation (GO:0018095)2.42099545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.64267244
2VDR_22108803_ChIP-Seq_LS180_Human2.90805173
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89613030
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.89552231
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.87443622
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.85393950
7TAF15_26573619_Chip-Seq_HEK293_Human2.82660742
8ZNF274_21170338_ChIP-Seq_K562_Hela2.64582527
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54249729
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.41471809
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32020903
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27443105
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12702222
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11982600
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09682543
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09633624
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07302690
18IGF1R_20145208_ChIP-Seq_DFB_Human2.03730670
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96174770
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94041906
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90825595
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89037548
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85014250
24GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.78299299
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77678047
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76854274
27EWS_26573619_Chip-Seq_HEK293_Human1.74509391
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70992082
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67190573
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66931799
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66040412
32ER_23166858_ChIP-Seq_MCF-7_Human1.63467810
33VDR_23849224_ChIP-Seq_CD4+_Human1.63430891
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62744048
35GBX2_23144817_ChIP-Seq_PC3_Human1.59934775
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58297910
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58204449
38P300_19829295_ChIP-Seq_ESCs_Human1.53435045
39ELK1_19687146_ChIP-ChIP_HELA_Human1.51926653
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50710077
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.50710077
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.48852495
43SOX2_19829295_ChIP-Seq_ESCs_Human1.46067693
44NANOG_19829295_ChIP-Seq_ESCs_Human1.46067693
45AR_21572438_ChIP-Seq_LNCaP_Human1.42062901
46FUS_26573619_Chip-Seq_HEK293_Human1.38667490
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37512360
48PRDM14_20953172_ChIP-Seq_ESCs_Human1.37417120
49AR_25329375_ChIP-Seq_VCAP_Human1.33769397
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31106391
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29089106
52GATA3_26560356_Chip-Seq_TH2_Human1.27495653
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.23732328
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.23207345
55AR_20517297_ChIP-Seq_VCAP_Human1.23086984
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22976970
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.22878589
58TP53_22573176_ChIP-Seq_HFKS_Human1.21981209
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.21499180
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19298892
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18906247
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.18357477
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.17791315
64REST_21632747_ChIP-Seq_MESCs_Mouse1.15256947
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12571648
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.10037883
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09764210
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08768918
69P53_22387025_ChIP-Seq_ESCs_Mouse1.07366025
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06901826
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.05969557
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05077233
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04019275
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03114323
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.02881626
76ERG_20517297_ChIP-Seq_VCAP_Human1.02396714
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.02025256
78CTCF_18555785_Chip-Seq_ESCs_Mouse1.01824808
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01759960
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99662744
81P300_18555785_Chip-Seq_ESCs_Mouse0.99165013
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98786178
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98553796
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97567168
85EZH2_27304074_Chip-Seq_ESCs_Mouse0.96934564
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96630425
87IRF8_22096565_ChIP-ChIP_GC-B_Human0.96489563
88RNF2_27304074_Chip-Seq_NSC_Mouse0.95335920
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.94316747
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94106070
91RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94096235
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93948491
93JUN_21703547_ChIP-Seq_K562_Human0.93826648
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93646504
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93646504
96SOX2_18555785_Chip-Seq_ESCs_Mouse0.93443009
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.93023332
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92455494
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92196070
100NCOR_22424771_ChIP-Seq_293T_Human0.92175875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern9.39742017
2MP0005671_abnormal_response_to2.78857761
3MP0002102_abnormal_ear_morphology2.76679515
4MP0001835_abnormal_antigen_presentation2.75457875
5MP0008995_early_reproductive_senescence2.74179019
6MP0003136_yellow_coat_color2.67233837
7MP0009379_abnormal_foot_pigmentation2.26247304
8MP0002653_abnormal_ependyma_morphology2.24805460
9MP0005084_abnormal_gallbladder_morpholo2.13768178
10MP0003938_abnormal_ear_development2.00491471
11MP0004145_abnormal_muscle_electrophysio1.99853077
12MP0006072_abnormal_retinal_apoptosis1.92837162
13MP0004142_abnormal_muscle_tone1.84038624
14MP0006292_abnormal_olfactory_placode1.78896912
15MP0003183_abnormal_peptide_metabolism1.58347848
16MP0005551_abnormal_eye_electrophysiolog1.57990983
17MP0002822_catalepsy1.57755763
18MP0009046_muscle_twitch1.56675026
19MP0003786_premature_aging1.48569037
20MP0002234_abnormal_pharynx_morphology1.48127358
21MP0001986_abnormal_taste_sensitivity1.48110381
22MP0001485_abnormal_pinna_reflex1.45326820
23MP0005253_abnormal_eye_physiology1.44810085
24MP0002163_abnormal_gland_morphology1.43555408
25MP0002277_abnormal_respiratory_mucosa1.41035264
26MP0002638_abnormal_pupillary_reflex1.38045386
27MP0001800_abnormal_humoral_immune1.37694021
28MP0000026_abnormal_inner_ear1.37304231
29MP0008877_abnormal_DNA_methylation1.36691501
30MP0003283_abnormal_digestive_organ1.35224102
31MP0002751_abnormal_autonomic_nervous1.32146236
32MP0003646_muscle_fatigue1.31038335
33MP0003011_delayed_dark_adaptation1.23924932
34MP0002876_abnormal_thyroid_physiology1.23867920
35MP0004147_increased_porphyrin_level1.20798736
36MP0002184_abnormal_innervation1.20606078
37MP0008789_abnormal_olfactory_epithelium1.20523015
38MP0001529_abnormal_vocalization1.17181779
39MP0002166_altered_tumor_susceptibility1.17019473
40MP0002272_abnormal_nervous_system1.14499991
41MP0008872_abnormal_physiological_respon1.14172253
42MP0006036_abnormal_mitochondrial_physio1.12732573
43MP0001790_abnormal_immune_system1.12601450
44MP0005387_immune_system_phenotype1.12601450
45MP0009333_abnormal_splenocyte_physiolog1.11576979
46MP0000631_abnormal_neuroendocrine_gland1.08682000
47MP0005645_abnormal_hypothalamus_physiol1.08111979
48MP0000685_abnormal_immune_system1.06495541
49MP0009785_altered_susceptibility_to1.05666571
50MP0003950_abnormal_plasma_membrane1.05383043
51MP0008961_abnormal_basal_metabolism1.02354602
52MP0001764_abnormal_homeostasis1.02157296
53MP0000778_abnormal_nervous_system0.95933992
54MP0001188_hyperpigmentation0.95679336
55MP0001905_abnormal_dopamine_level0.93558354
56MP0002282_abnormal_trachea_morphology0.93086516
57MP0005000_abnormal_immune_tolerance0.93006096
58MP0000955_abnormal_spinal_cord0.92628047
59MP0002095_abnormal_skin_pigmentation0.92538829
60MP0005075_abnormal_melanosome_morpholog0.92355555
61MP0000427_abnormal_hair_cycle0.91238501
62MP0002928_abnormal_bile_duct0.90135220
63MP0002006_tumorigenesis0.89546341
64MP0001486_abnormal_startle_reflex0.89339825
65MP0009745_abnormal_behavioral_response0.89300824
66MP0002148_abnormal_hypersensitivity_rea0.87548294
67MP0004133_heterotaxia0.86662587
68MP0005195_abnormal_posterior_eye0.84536218
69MP0004885_abnormal_endolymph0.84029199
70MP0002723_abnormal_immune_serum0.82272006
71MP0001293_anophthalmia0.81292034
72MP0002572_abnormal_emotion/affect_behav0.79179568
73MP0001119_abnormal_female_reproductive0.78852025
74MP0006035_abnormal_mitochondrial_morpho0.78436150
75MP0001346_abnormal_lacrimal_gland0.77667077
76MP0003787_abnormal_imprinting0.76435292
77MP0000383_abnormal_hair_follicle0.75023273
78MP0002420_abnormal_adaptive_immunity0.74579425
79MP0003724_increased_susceptibility_to0.74466982
80MP0002752_abnormal_somatic_nervous0.73812888
81MP0005499_abnormal_olfactory_system0.72212948
82MP0005394_taste/olfaction_phenotype0.72212948
83MP0002452_abnormal_antigen_presenting0.71941279
84MP0002736_abnormal_nociception_after0.71926470
85MP0001970_abnormal_pain_threshold0.71750713
86MP0001819_abnormal_immune_cell0.71444228
87MP0009764_decreased_sensitivity_to0.70787798
88MP0001286_abnormal_eye_development0.69965473
89MP0002064_seizures0.69017099
90MP0003879_abnormal_hair_cell0.68459118
91MP0004215_abnormal_myocardial_fiber0.64306333
92MP0003635_abnormal_synaptic_transmissio0.64018234
93MP0001765_abnormal_ion_homeostasis0.63583339
94MP0006276_abnormal_autonomic_nervous0.63529030
95MP0002735_abnormal_chemical_nociception0.63131062
96MP0009250_abnormal_appendicular_skeleto0.62578634
97MP0005379_endocrine/exocrine_gland_phen0.62180723
98MP0001984_abnormal_olfaction0.61631850
99MP0005025_abnormal_response_to0.60561086
100MP0005646_abnormal_pituitary_gland0.60525287

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)5.93128748
2Fibular aplasia (HP:0002990)5.30064406
3Hypoplastic pelvis (HP:0008839)4.85658694
4Oligodactyly (HP:0012165)4.28373377
5Split foot (HP:0001839)4.08112038
6Synostosis involving the elbow (HP:0003938)3.97892507
7Humeroradial synostosis (HP:0003041)3.97892507
8Aplasia/hypoplasia of the uterus (HP:0008684)3.91855788
9Adactyly (HP:0009776)3.78334096
10Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.69401621
11Mitochondrial inheritance (HP:0001427)3.52293970
12Acute necrotizing encephalopathy (HP:0006965)3.51167571
13Absent/shortened dynein arms (HP:0200106)3.49677176
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.49677176
15Increased CSF lactate (HP:0002490)3.45802192
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.39569031
17Chronic sinusitis (HP:0011109)3.32312762
18Radial bowing (HP:0002986)3.20227918
19Congenital stationary night blindness (HP:0007642)3.08683131
20Progressive macrocephaly (HP:0004481)3.00960560
21Abnormal finger flexion creases (HP:0006143)2.99435316
22Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.95131226
23Acute encephalopathy (HP:0006846)2.89075661
24Symphalangism affecting the phalanges of the hand (HP:0009773)2.87890884
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85942683
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85942683
27Abnormal mitochondria in muscle tissue (HP:0008316)2.85119243
28Abnormal ciliary motility (HP:0012262)2.82994214
29Aplasia/Hypoplasia of the ulna (HP:0006495)2.81398332
30Increased hepatocellular lipid droplets (HP:0006565)2.79679650
31Hepatocellular necrosis (HP:0001404)2.69396929
32Lipid accumulation in hepatocytes (HP:0006561)2.63334276
33Abnormality of midbrain morphology (HP:0002418)2.61392948
34Molar tooth sign on MRI (HP:0002419)2.61392948
35Abnormal respiratory epithelium morphology (HP:0012253)2.56790102
36Abnormal respiratory motile cilium morphology (HP:0005938)2.56790102
37Hypoplastic nipples (HP:0002557)2.48670068
38Supernumerary spleens (HP:0009799)2.48544790
39Myokymia (HP:0002411)2.45432880
40Barrel-shaped chest (HP:0001552)2.40312948
41Hypoplasia of the radius (HP:0002984)2.39742873
42Abnormal respiratory motile cilium physiology (HP:0012261)2.39074230
43Renal Fanconi syndrome (HP:0001994)2.35740032
44Increased IgM level (HP:0003496)2.33328502
45Alveolar cell carcinoma (HP:0006519)2.32192868
46Aplasia/Hypoplasia of the fibula (HP:0006492)2.29870311
47Type II lissencephaly (HP:0007260)2.29250807
48Cerebral edema (HP:0002181)2.27096020
49Large eyes (HP:0001090)2.26307410
50Abnormality of the pubic bones (HP:0003172)2.25112388
51Broad ribs (HP:0000885)2.22165778
52Neoplasm of the tracheobronchial system (HP:0100552)2.20535318
53Hemivertebrae (HP:0002937)2.18701621
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18124116
55Forearm undergrowth (HP:0009821)2.15859162
56Hepatic necrosis (HP:0002605)2.15188314
57Abolished electroretinogram (ERG) (HP:0000550)2.15019607
58Azoospermia (HP:0000027)2.14388729
59Increased serum lactate (HP:0002151)2.13981600
60Aplasia involving forearm bones (HP:0009822)2.12662341
61Absent forearm bone (HP:0003953)2.12662341
62Optic disc pallor (HP:0000543)2.10603912
63IgG deficiency (HP:0004315)2.05729278
64Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.01676415
65Increased intramyocellular lipid droplets (HP:0012240)1.97995044
66Pancreatic cysts (HP:0001737)1.95576604
67Abnormal spermatogenesis (HP:0008669)1.94750504
68Hypoplastic iliac wings (HP:0002866)1.94059237
69Hypothermia (HP:0002045)1.94047072
703-Methylglutaconic aciduria (HP:0003535)1.92043964
71Rib fusion (HP:0000902)1.91956188
72Exertional dyspnea (HP:0002875)1.90979237
73Hypoproteinemia (HP:0003075)1.90436760
74Elevated erythrocyte sedimentation rate (HP:0003565)1.90299023
75B lymphocytopenia (HP:0010976)1.88752368
76Abnormality of B cell number (HP:0010975)1.88327676
77Recurrent bronchitis (HP:0002837)1.86767079
78Decreased circulating renin level (HP:0003351)1.85335850
79Bowing of the arm (HP:0006488)1.83941987
80Bowed forearm bones (HP:0003956)1.83941987
81Bronchitis (HP:0012387)1.83568035
82Patellar aplasia (HP:0006443)1.81102789
83Chronic bronchitis (HP:0004469)1.78914880
84True hermaphroditism (HP:0010459)1.76588923
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76422572
86Aplasia/Hypoplasia of the patella (HP:0006498)1.74980497
87Septo-optic dysplasia (HP:0100842)1.73391611
88Pancreatic fibrosis (HP:0100732)1.73246160
89Inability to walk (HP:0002540)1.73105682
90Abnormal rod and cone electroretinograms (HP:0008323)1.70250998
91Postaxial hand polydactyly (HP:0001162)1.68960983
92Nephronophthisis (HP:0000090)1.68116047
93Lactic acidosis (HP:0003128)1.67705857
94Abnormality of macular pigmentation (HP:0008002)1.66480891
95Abnormality of T cell number (HP:0011839)1.66204181
96Increased muscle lipid content (HP:0009058)1.66202460
97Parakeratosis (HP:0001036)1.63352524
98Congenital, generalized hypertrichosis (HP:0004540)1.63144526
99Cystic liver disease (HP:0006706)1.62910774
100Stomatitis (HP:0010280)1.62890850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR24.65686535
2TAOK34.08683596
3TXK3.74449033
4TNIK3.34068421
5CDK193.23642290
6MAP4K22.44483463
7MAP3K122.38462997
8TLK12.34508873
9WNK42.30665955
10ERBB32.27944673
11MUSK2.07451747
12PINK11.97479385
13SCYL21.88625482
14GRK11.80224846
15WNK31.71436612
16ADRBK21.70429722
17MAP4K11.59723782
18EIF2AK11.51829323
19VRK21.40062350
20STK391.38630042
21RIPK41.37330615
22EIF2AK31.30439270
23MYLK1.29652649
24TSSK61.28881126
25AKT31.28622852
26ZAK1.24322049
27KDR1.23474662
28ILK1.23360098
29STK38L1.14395189
30VRK11.10114915
31BMPR1B1.09601321
32MAP2K71.08583885
33CDK81.07729222
34PKN11.03781935
35CAMKK21.01452921
36SYK1.00740532
37STK161.00241666
38OXSR10.97599351
39MAP2K60.95750544
40IKBKB0.93170858
41DYRK20.91771503
42GRK70.91510258
43MAPK150.91159682
44BCR0.89164929
45TEC0.88374952
46MAP3K40.88333492
47FRK0.83332399
48OBSCN0.79040664
49PIK3CG0.74228229
50CSF1R0.73816824
51ITK0.71064735
52INSRR0.70845082
53MAPK130.70072366
54LYN0.68263891
55TRPM70.67228117
56SRPK10.59988437
57BTK0.59807468
58LCK0.59579193
59EIF2AK20.59078140
60PLK40.56401713
61CCNB10.55935736
62ADRBK10.54425632
63IKBKE0.53521763
64DYRK1B0.53143724
65BCKDK0.53140887
66ERBB20.50115309
67FES0.49845527
68BRSK20.49379701
69PHKG20.49022340
70PHKG10.49022340
71ROCK10.48928646
72CAMK2A0.48724514
73PRKCQ0.48143202
74MST40.47828554
75PRKCG0.46624798
76PRKACA0.45005942
77TIE10.43053449
78HCK0.41117956
79PRKCA0.41024894
80PRKCE0.40153888
81IGF1R0.39223538
82NTRK20.39214127
83CAMK10.39121518
84GRK60.38313181
85PRKG10.38041171
86MARK30.37851720
87CASK0.37299434
88ABL10.36957892
89PRKCB0.36700610
90JAK30.35638784
91MINK10.35269286
92CSNK2A10.34282134
93TRIM280.33614466
94PLK30.33286318
95AURKB0.32988786
96CSK0.31327609
97PLK20.31214350
98CAMK2D0.30314311
99NEK10.29949988
100WNK10.28842587

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.09639796
2Parkinsons disease_Homo sapiens_hsa050123.93528055
3Asthma_Homo sapiens_hsa053103.77106200
4Proteasome_Homo sapiens_hsa030503.43872680
5Autoimmune thyroid disease_Homo sapiens_hsa053203.04320481
6Graft-versus-host disease_Homo sapiens_hsa053322.94828506
7Allograft rejection_Homo sapiens_hsa053302.93464424
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.87840744
9Ribosome_Homo sapiens_hsa030102.64673898
10Type I diabetes mellitus_Homo sapiens_hsa049402.47667692
11Alzheimers disease_Homo sapiens_hsa050102.45378046
12Huntingtons disease_Homo sapiens_hsa050162.24964862
13Cardiac muscle contraction_Homo sapiens_hsa042602.19772529
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17569093
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96294026
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80855295
17Primary immunodeficiency_Homo sapiens_hsa053401.79661104
18Protein export_Homo sapiens_hsa030601.78123027
19Phototransduction_Homo sapiens_hsa047441.77223825
20Rheumatoid arthritis_Homo sapiens_hsa053231.72561102
21RNA polymerase_Homo sapiens_hsa030201.68998279
22Antigen processing and presentation_Homo sapiens_hsa046121.64386301
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50418776
24Viral myocarditis_Homo sapiens_hsa054161.25042926
25Linoleic acid metabolism_Homo sapiens_hsa005911.22932026
26One carbon pool by folate_Homo sapiens_hsa006701.18587003
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14649098
28Basal transcription factors_Homo sapiens_hsa030221.14435172
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14249594
30Morphine addiction_Homo sapiens_hsa050321.13998485
31Nicotine addiction_Homo sapiens_hsa050331.12105507
32Collecting duct acid secretion_Homo sapiens_hsa049661.11649202
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05512834
34Homologous recombination_Homo sapiens_hsa034401.05295309
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.02925502
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98041204
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95891273
38Systemic lupus erythematosus_Homo sapiens_hsa053220.93945354
39Staphylococcus aureus infection_Homo sapiens_hsa051500.93261292
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92726799
41Nucleotide excision repair_Homo sapiens_hsa034200.90951257
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90356983
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88975784
44Olfactory transduction_Homo sapiens_hsa047400.87781483
45Nitrogen metabolism_Homo sapiens_hsa009100.83510683
46RNA degradation_Homo sapiens_hsa030180.79706630
47Hematopoietic cell lineage_Homo sapiens_hsa046400.77530701
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76275927
49Amphetamine addiction_Homo sapiens_hsa050310.76082941
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71277204
51Ether lipid metabolism_Homo sapiens_hsa005650.69871815
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68174321
53Arachidonic acid metabolism_Homo sapiens_hsa005900.66975400
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63009470
55Tryptophan metabolism_Homo sapiens_hsa003800.62366501
56Purine metabolism_Homo sapiens_hsa002300.61516609
57Cocaine addiction_Homo sapiens_hsa050300.61292018
58Taste transduction_Homo sapiens_hsa047420.58992523
59Peroxisome_Homo sapiens_hsa041460.56869796
60Leishmaniasis_Homo sapiens_hsa051400.54329594
61Propanoate metabolism_Homo sapiens_hsa006400.53501679
62GABAergic synapse_Homo sapiens_hsa047270.51356411
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.50367830
64Caffeine metabolism_Homo sapiens_hsa002320.50333797
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46614532
66Basal cell carcinoma_Homo sapiens_hsa052170.44421895
67Butanoate metabolism_Homo sapiens_hsa006500.42229287
68Hedgehog signaling pathway_Homo sapiens_hsa043400.41962673
69Dopaminergic synapse_Homo sapiens_hsa047280.37815756
70T cell receptor signaling pathway_Homo sapiens_hsa046600.37661343
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.37629614
72Selenocompound metabolism_Homo sapiens_hsa004500.37220458
73Metabolic pathways_Homo sapiens_hsa011000.36953231
74Calcium signaling pathway_Homo sapiens_hsa040200.36702988
75Tuberculosis_Homo sapiens_hsa051520.35400652
76Glutamatergic synapse_Homo sapiens_hsa047240.34875670
77Serotonergic synapse_Homo sapiens_hsa047260.34779911
78Chemical carcinogenesis_Homo sapiens_hsa052040.33546097
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33346530
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33156259
81Retinol metabolism_Homo sapiens_hsa008300.32351104
82Circadian entrainment_Homo sapiens_hsa047130.31960380
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30493187
84Axon guidance_Homo sapiens_hsa043600.27394833
85Spliceosome_Homo sapiens_hsa030400.27101323
86Ovarian steroidogenesis_Homo sapiens_hsa049130.26531710
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26399618
88Insulin secretion_Homo sapiens_hsa049110.25134029
89Alcoholism_Homo sapiens_hsa050340.24384009
90Phagosome_Homo sapiens_hsa041450.23268624
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.22826657
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22622403
93Pyrimidine metabolism_Homo sapiens_hsa002400.20743887
94Fanconi anemia pathway_Homo sapiens_hsa034600.20426332
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19929769
96Base excision repair_Homo sapiens_hsa034100.18862171
97Sulfur metabolism_Homo sapiens_hsa009200.17976320
98DNA replication_Homo sapiens_hsa030300.17465554
99Fat digestion and absorption_Homo sapiens_hsa049750.16831320
100Legionellosis_Homo sapiens_hsa051340.16326311

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