SUB1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of response to tumor cell (GO:0002834)8.55972632
2positive regulation of response to tumor cell (GO:0002836)8.55972632
3positive regulation of immune response to tumor cell (GO:0002839)8.55972632
4regulation of immune response to tumor cell (GO:0002837)8.55972632
5negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)8.11968527
6proline metabolic process (GO:0006560)7.48401404
7lymphoid progenitor cell differentiation (GO:0002320)6.00376092
8positive regulation by host of viral transcription (GO:0043923)5.90102273
9neuronal action potential propagation (GO:0019227)5.87027740
10negative regulation of interleukin-17 production (GO:0032700)5.43887143
11regulation of clathrin-mediated endocytosis (GO:2000369)5.43247695
12mitochondrial genome maintenance (GO:0000002)5.11581652
13negative regulation by host of viral transcription (GO:0043922)5.11474892
14defense response to protozoan (GO:0042832)5.11427709
15positive regulation of muscle cell apoptotic process (GO:0010661)4.67237851
16necroptotic process (GO:0070266)4.61705291
17positive regulation of microtubule polymerization (GO:0031116)4.54149853
18glutamine family amino acid biosynthetic process (GO:0009084)4.47794522
19ribosomal small subunit assembly (GO:0000028)4.35505945
20regulation of smooth muscle cell apoptotic process (GO:0034391)4.30827964
21response to protozoan (GO:0001562)4.22220897
22response to gravity (GO:0009629)4.09799369
23poly(A)+ mRNA export from nucleus (GO:0016973)4.04891758
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.04084400
25neutrophil mediated immunity (GO:0002446)4.01387491
26positive regulation of granulocyte differentiation (GO:0030854)4.00132200
27ncRNA 3-end processing (GO:0043628)3.99716194
28modulation by host of viral transcription (GO:0043921)3.95233974
29modulation by host of symbiont transcription (GO:0052472)3.95233974
30modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.85901197
31negative regulation of telomere maintenance (GO:0032205)3.83423986
32maintenance of protein location in nucleus (GO:0051457)3.81913289
33programmed necrotic cell death (GO:0097300)3.75258074
34positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.74919871
35positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.72526454
36necrotic cell death (GO:0070265)3.72234730
37regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.70011087
38spliceosomal complex assembly (GO:0000245)3.69273688
39rRNA catabolic process (GO:0016075)3.65977665
40regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.62117783
41negative regulation of telomerase activity (GO:0051974)3.58570151
42primitive streak formation (GO:0090009)3.58356302
43short-term memory (GO:0007614)3.57112325
44positive regulation of natural killer cell activation (GO:0032816)3.51981028
45proteasome assembly (GO:0043248)3.50046368
46acrosome assembly (GO:0001675)3.46552403
47positive regulation of natural killer cell mediated immunity (GO:0002717)3.42906675
48endothelial cell morphogenesis (GO:0001886)3.42889183
49chaperone-mediated protein transport (GO:0072321)3.39051084
50uterus development (GO:0060065)3.38404372
51interkinetic nuclear migration (GO:0022027)3.32041998
52cellular response to dsRNA (GO:0071359)3.30500635
53histone H3-K9 methylation (GO:0051567)3.30280845
54regulation of natural killer cell activation (GO:0032814)3.28870358
55response to UV-B (GO:0010224)3.28004153
56single strand break repair (GO:0000012)3.27841494
57positive regulation of translational initiation (GO:0045948)3.26195874
58ovulation cycle (GO:0042698)3.25325478
59neural tube formation (GO:0001841)3.21719484
60tachykinin receptor signaling pathway (GO:0007217)3.16917410
61positive regulation of defense response to virus by host (GO:0002230)3.14579771
62positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10539230
63regulation of interleukin-17 production (GO:0032660)3.07589500
64fusion of sperm to egg plasma membrane (GO:0007342)3.07042063
65head development (GO:0060322)3.01415409
66endosome to lysosome transport (GO:0008333)3.01222977
67forebrain neuron differentiation (GO:0021879)2.99982284
68serotonin metabolic process (GO:0042428)2.98622285
69regulation of gene expression by genetic imprinting (GO:0006349)2.96863121
70mast cell activation involved in immune response (GO:0002279)2.94928873
71mast cell degranulation (GO:0043303)2.94928873
72forebrain morphogenesis (GO:0048853)2.94392204
73somite development (GO:0061053)2.93935975
74cornea development in camera-type eye (GO:0061303)2.90163977
75regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.89950285
76myeloid leukocyte mediated immunity (GO:0002444)2.86596910
77signal transduction involved in regulation of gene expression (GO:0023019)2.84351004
78microtubule nucleation (GO:0007020)2.79796319
79detection of temperature stimulus (GO:0016048)2.79504499
80bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79317002
81negative regulation of astrocyte differentiation (GO:0048712)2.78658098
82cell proliferation in forebrain (GO:0021846)2.78121287
83cranial nerve development (GO:0021545)2.77040343
84histone H3-K9 modification (GO:0061647)2.76685041
85sulfation (GO:0051923)2.73324180
86negative regulation of mast cell activation (GO:0033004)2.72265706
87kynurenine metabolic process (GO:0070189)2.70550336
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70299656
89primary amino compound metabolic process (GO:1901160)2.69953367
90termination of RNA polymerase III transcription (GO:0006386)2.69539917
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.69539917
92CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.68761379
93magnesium ion transport (GO:0015693)2.67808349
94neuronal action potential (GO:0019228)2.67671517
95regulation of telomerase activity (GO:0051972)2.65029452
96osteoblast development (GO:0002076)2.63711747
97left/right axis specification (GO:0070986)2.63423772
98axoneme assembly (GO:0035082)2.62138199
99mast cell activation (GO:0045576)2.59708417
100proline biosynthetic process (GO:0006561)10.7452378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.65999553
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.07007314
3VDR_22108803_ChIP-Seq_LS180_Human4.27402465
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.28566560
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.26183612
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10984626
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.04520971
8ZNF274_21170338_ChIP-Seq_K562_Hela2.65411852
9IGF1R_20145208_ChIP-Seq_DFB_Human2.45691082
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16760187
11EZH2_22144423_ChIP-Seq_EOC_Human2.16474703
12MYC_18940864_ChIP-ChIP_HL60_Human2.13876871
13ER_23166858_ChIP-Seq_MCF-7_Human1.96292087
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88508175
15TOP2B_26459242_ChIP-Seq_MCF-7_Human1.82517745
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77056691
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71294466
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67323950
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66881321
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.59948843
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.59793213
22GBX2_23144817_ChIP-Seq_PC3_Human1.54783588
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50101641
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48819352
25FOXA1_21572438_ChIP-Seq_LNCaP_Human1.48322460
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.47998046
27P300_19829295_ChIP-Seq_ESCs_Human1.47639985
28FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46107048
29FOXA1_25329375_ChIP-Seq_VCAP_Human1.46107048
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.45333035
31TAF15_26573619_Chip-Seq_HEK293_Human1.44608764
32PRDM14_20953172_ChIP-Seq_ESCs_Human1.43176985
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42781998
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39615208
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39188323
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38503527
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.37970116
38EWS_26573619_Chip-Seq_HEK293_Human1.33916119
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29289196
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.27806818
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25951199
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.21522222
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20484252
44SMAD4_21799915_ChIP-Seq_A2780_Human1.20117930
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18641837
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17689690
47RUNX2_22187159_ChIP-Seq_PCA_Human1.17293917
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.15543634
49IRF1_19129219_ChIP-ChIP_H3396_Human1.15384903
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15100231
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14761709
52JUN_21703547_ChIP-Seq_K562_Human1.14746384
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.13194868
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12188468
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11882265
56RNF2_27304074_Chip-Seq_NSC_Mouse1.11342501
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10971243
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10515189
59BCAT_22108803_ChIP-Seq_LS180_Human1.08396377
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07921816
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04735195
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.04537023
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.03366553
64AR_25329375_ChIP-Seq_VCAP_Human1.03224884
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02381186
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02062799
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02027562
68RUNX_20019798_ChIP-Seq_JUKART_Human1.01652168
69HOXB7_26014856_ChIP-Seq_BT474_Human0.98566778
70SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98343143
71EZH2_27294783_Chip-Seq_NPCs_Mouse0.97134356
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96944667
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96723446
74SMAD3_21741376_ChIP-Seq_EPCs_Human0.96304469
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96255217
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96059315
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95200685
78TP53_22573176_ChIP-Seq_HFKS_Human0.94358095
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94186588
80RBPJ_21746931_ChIP-Seq_IB4_Human0.94007299
81TCF4_23295773_ChIP-Seq_U87_Human0.93997908
82GATA3_21867929_ChIP-Seq_TH1_Mouse0.93972554
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92856150
84VDR_23849224_ChIP-Seq_CD4+_Human0.92661342
85GATA3_26560356_Chip-Seq_TH1_Human0.91819567
86HNFA_21074721_ChIP-Seq_CACO-2_Human0.91804522
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91049991
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90708037
89AR_20517297_ChIP-Seq_VCAP_Human0.90506152
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90156088
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90156088
92TCF4_18268006_ChIP-ChIP_LS174T_Human0.90068536
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89581926
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.89437373
95P53_22387025_ChIP-Seq_ESCs_Mouse0.89270040
96P300_18555785_Chip-Seq_ESCs_Mouse0.89260929
97SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89148708
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86981212
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86420828
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.86085793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio4.66077299
2MP0006292_abnormal_olfactory_placode4.57355752
3MP0002102_abnormal_ear_morphology3.37751558
4MP0003315_abnormal_perineum_morphology3.08584709
5MP0002736_abnormal_nociception_after3.03587352
6MP0004147_increased_porphyrin_level2.62350150
7MP0003787_abnormal_imprinting2.47991717
8MP0004885_abnormal_endolymph2.32779256
9MP0002163_abnormal_gland_morphology2.20835174
10MP0001968_abnormal_touch/_nociception2.19227435
11MP0005645_abnormal_hypothalamus_physiol2.11760292
12MP0000569_abnormal_digit_pigmentation2.09933413
13MP0001188_hyperpigmentation1.96547777
14MP0002876_abnormal_thyroid_physiology1.95818953
15MP0002160_abnormal_reproductive_system1.95053477
16MP0004133_heterotaxia1.93352080
17MP0002233_abnormal_nose_morphology1.91813305
18MP0003890_abnormal_embryonic-extraembry1.90036909
19MP0008877_abnormal_DNA_methylation1.72952733
20MP0010386_abnormal_urinary_bladder1.72864599
21MP0000681_abnormal_thyroid_gland1.64113919
22MP0000427_abnormal_hair_cycle1.61179994
23MP0005646_abnormal_pituitary_gland1.59554175
24MP0001293_anophthalmia1.56917123
25MP0005174_abnormal_tail_pigmentation1.52743680
26MP0004036_abnormal_muscle_relaxation1.50658967
27MP0003943_abnormal_hepatobiliary_system1.50511211
28MP0001873_stomach_inflammation1.48194103
29MP0008872_abnormal_physiological_respon1.46980445
30MP0005257_abnormal_intraocular_pressure1.46885615
31MP0002148_abnormal_hypersensitivity_rea1.44700586
32MP0002272_abnormal_nervous_system1.42983902
33MP0003136_yellow_coat_color1.42628429
34MP0004134_abnormal_chest_morphology1.42415688
35MP0000631_abnormal_neuroendocrine_gland1.41922018
36MP0004742_abnormal_vestibular_system1.40522202
37MP0008995_early_reproductive_senescence1.40516071
38MP0009765_abnormal_xenobiotic_induced1.36978534
39MP0005084_abnormal_gallbladder_morpholo1.35118562
40MP0003252_abnormal_bile_duct1.24472954
41MP0001485_abnormal_pinna_reflex1.24343554
42MP0002733_abnormal_thermal_nociception1.24138344
43MP0002928_abnormal_bile_duct1.23283274
44MP0002177_abnormal_outer_ear1.21046901
45MP0003937_abnormal_limbs/digits/tail_de1.19592709
46MP0005075_abnormal_melanosome_morpholog1.18304458
47MP0003646_muscle_fatigue1.16796483
48MP0005671_abnormal_response_to1.16128926
49MP0001542_abnormal_bone_strength1.15308862
50MP0005379_endocrine/exocrine_gland_phen1.14787847
51MP0005377_hearing/vestibular/ear_phenot1.13818042
52MP0003878_abnormal_ear_physiology1.13818042
53MP0009053_abnormal_anal_canal1.12226639
54MP0003567_abnormal_fetal_cardiomyocyte1.11377347
55MP0003880_abnormal_central_pattern1.09566594
56MP0001664_abnormal_digestion1.09268628
57MP0002735_abnormal_chemical_nociception1.06516398
58MP0000049_abnormal_middle_ear1.05817099
59MP0005000_abnormal_immune_tolerance1.03755468
60MP0004883_abnormal_blood_vessel1.03583914
61MP0002067_abnormal_sensory_capabilities1.01163382
62MP0001486_abnormal_startle_reflex0.96386581
63MP0002837_dystrophic_cardiac_calcinosis0.96342454
64MP0003866_abnormal_defecation0.90278649
65MP0009250_abnormal_appendicular_skeleto0.89695406
66MP0000372_irregular_coat_pigmentation0.89122268
67MP0008789_abnormal_olfactory_epithelium0.88225719
68MP0005389_reproductive_system_phenotype0.87619429
69MP0004142_abnormal_muscle_tone0.86954622
70MP0001663_abnormal_digestive_system0.86913339
71MP0009745_abnormal_behavioral_response0.85983897
72MP0002405_respiratory_system_inflammati0.85762797
73MP0010368_abnormal_lymphatic_system0.85222645
74MP0001346_abnormal_lacrimal_gland0.84429785
75MP0005423_abnormal_somatic_nervous0.83657362
76MP0003698_abnormal_male_reproductive0.82267207
77MP0005187_abnormal_penis_morphology0.81996330
78MP0002210_abnormal_sex_determination0.79578669
79MP0005551_abnormal_eye_electrophysiolog0.77843828
80MP0003938_abnormal_ear_development0.74955679
81MP0001905_abnormal_dopamine_level0.74865161
82MP0001970_abnormal_pain_threshold0.73950924
83MP0005085_abnormal_gallbladder_physiolo0.73809177
84MP0005220_abnormal_exocrine_pancreas0.73092855
85MP0002998_abnormal_bone_remodeling0.72501801
86MP0002063_abnormal_learning/memory/cond0.71091796
87MP0002572_abnormal_emotion/affect_behav0.70535735
88MP0001963_abnormal_hearing_physiology0.68999408
89MP0005386_behavior/neurological_phenoty0.65092686
90MP0004924_abnormal_behavior0.65092686
91MP0002114_abnormal_axial_skeleton0.64667098
92MP0000778_abnormal_nervous_system0.64205897
93MP0001800_abnormal_humoral_immune0.63753775
94MP0002229_neurodegeneration0.63580757
95MP0001286_abnormal_eye_development0.63492078
96MP0002249_abnormal_larynx_morphology0.62722106
97MP0002557_abnormal_social/conspecific_i0.62569825
98MP0001119_abnormal_female_reproductive0.62142197
99MP0005499_abnormal_olfactory_system0.61065915
100MP0005394_taste/olfaction_phenotype0.61065915

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)7.81330651
2Progressive cerebellar ataxia (HP:0002073)5.89078979
3Scanning speech (HP:0002168)4.99540296
4Constricted visual fields (HP:0001133)4.76360754
5Muscle hypertrophy of the lower extremities (HP:0008968)4.58547005
6Dysmetric saccades (HP:0000641)4.47053448
7Absent rod-and cone-mediated responses on ERG (HP:0007688)4.33139971
8Megalencephaly (HP:0001355)4.17739275
9Gaze-evoked nystagmus (HP:0000640)3.97087056
10Progressive hearing impairment (HP:0001730)3.83650501
11Tubular atrophy (HP:0000092)3.72483930
12Urinary bladder sphincter dysfunction (HP:0002839)3.65240110
13Optic disc pallor (HP:0000543)3.62184188
14Molar tooth sign on MRI (HP:0002419)3.46705614
15Abnormality of midbrain morphology (HP:0002418)3.46705614
16Myotonia (HP:0002486)3.42715150
17Premature ovarian failure (HP:0008209)3.42677259
18Tubulointerstitial fibrosis (HP:0005576)3.10635614
19Chronic hepatic failure (HP:0100626)3.04639958
20Abnormality of the renal cortex (HP:0011035)3.01787758
21Abnormality of macular pigmentation (HP:0008002)2.90593149
22Abnormal rod and cone electroretinograms (HP:0008323)2.81834307
23Abnormality of the phalanges of the 2nd finger (HP:0009541)2.80460774
24Severe combined immunodeficiency (HP:0004430)2.78374142
25Oral leukoplakia (HP:0002745)2.74354113
26Short middle phalanx of the 5th finger (HP:0004220)2.66980976
27Metaphyseal dysplasia (HP:0100255)2.66036799
28Intestinal atresia (HP:0011100)2.64503929
29Abnormality of eosinophils (HP:0001879)2.64384622
30Slow saccadic eye movements (HP:0000514)2.60070139
31Thyroiditis (HP:0100646)2.59106735
32Abnormality of alanine metabolism (HP:0010916)2.54786848
33Hyperalaninemia (HP:0003348)2.54786848
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54786848
35Sparse lateral eyebrow (HP:0005338)2.52808864
36Dysdiadochokinesis (HP:0002075)2.52447614
37Cupped ear (HP:0000378)2.52184838
38Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.51287265
39Abnormality of the renal medulla (HP:0100957)2.47703210
40Abnormality of B cell number (HP:0010975)2.40689030
41Secondary amenorrhea (HP:0000869)2.38616846
42Polydipsia (HP:0001959)2.37791451
43Abnormal drinking behavior (HP:0030082)2.37791451
44Attenuation of retinal blood vessels (HP:0007843)2.36623082
45Thin bony cortex (HP:0002753)2.35998597
46Abnormality of the phalanges of the 5th finger (HP:0004213)2.35052534
47Asplenia (HP:0001746)2.34453823
48Tubulointerstitial abnormality (HP:0001969)2.33726276
49Urethral obstruction (HP:0000796)2.30296471
50Cutis marmorata (HP:0000965)2.28110928
51Renal cortical cysts (HP:0000803)2.27491766
52Abnormal biliary tract physiology (HP:0012439)2.26396368
53Bile duct proliferation (HP:0001408)2.26396368
54Nephronophthisis (HP:0000090)2.25676165
55Bulbar palsy (HP:0001283)2.23913292
56Truncal ataxia (HP:0002078)2.22517225
57Nonprogressive disorder (HP:0003680)2.21999466
58Delayed epiphyseal ossification (HP:0002663)2.20673737
59Enlarged epiphyses (HP:0010580)2.17716361
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.15653892
61Abnormality of the pubic bones (HP:0003172)2.15215533
62Oculomotor apraxia (HP:0000657)2.14762420
63Combined immunodeficiency (HP:0005387)2.14376132
64Spondylolisthesis (HP:0003302)2.14036951
65Impaired vibratory sensation (HP:0002495)2.12233463
66Volvulus (HP:0002580)2.10003645
67Pancreatic fibrosis (HP:0100732)2.09651533
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.08040663
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08040663
70Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.05034444
71Neonatal respiratory distress (HP:0002643)2.04165848
72Morphological abnormality of the middle ear (HP:0008609)2.02860263
73Impaired smooth pursuit (HP:0007772)2.00534053
74Decreased circulating renin level (HP:0003351)1.99958298
75Abolished electroretinogram (ERG) (HP:0000550)1.97733366
76Progressive inability to walk (HP:0002505)1.95655030
77Osteomalacia (HP:0002749)1.94884768
78Abnormality of the preputium (HP:0100587)1.94477786
79Supernumerary spleens (HP:0009799)1.91544013
80Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.89948327
81Congenital hepatic fibrosis (HP:0002612)1.89434054
82Abnormality of the nasal septum (HP:0000419)1.89077078
83Potter facies (HP:0002009)1.85792466
84Facial shape deformation (HP:0011334)1.85792466
85Acute lymphatic leukemia (HP:0006721)1.80910807
86Neoplasm of the adrenal cortex (HP:0100641)1.77812534
87Pancreatic cysts (HP:0001737)1.76982499
88Abnormality of the 2nd finger (HP:0004100)1.75547321
89Gastrointestinal atresia (HP:0002589)1.75064560
90Hematochezia (HP:0002573)1.72801937
91Irregular vertebral endplates (HP:0003301)1.71197903
92Short chin (HP:0000331)1.70231919
93Brushfield spots (HP:0001088)1.68722287
94Morphological abnormality of the pyramidal tract (HP:0002062)1.68370791
95Congenital stationary night blindness (HP:0007642)1.68216537
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.67611371
97Enlarged kidneys (HP:0000105)1.67056900
98B lymphocytopenia (HP:0010976)1.66462064
99Fetal akinesia sequence (HP:0001989)1.64141963
100Colon cancer (HP:0003003)1.63093669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRPM77.26373787
2FRK5.58350199
3IRAK13.22451061
4CDK193.13120121
5KIT2.93604586
6ILK2.75773150
7MATK2.07509652
8ADRBK22.07362435
9EIF2AK31.96781298
10TRIM281.96266079
11BRSK21.90341001
12CAMKK21.79882433
13NUAK11.78715283
14OXSR11.73299933
15MKNK21.66060740
16RPS6KA41.62265836
17MAP3K61.55955646
18BMPR1B1.47284171
19MKNK11.43420428
20MAP3K71.39167317
21FLT31.31770527
22CDK81.29380870
23ACVR1B1.25822725
24DMPK1.20924531
25BCR1.18238468
26ZAK1.10289086
27TEC1.09287783
28GRK11.07301479
29IRAK21.02569408
30TNK21.01599617
31PRKCH0.98439542
32MINK10.95748903
33PDK10.93297385
34PRKCG0.87777733
35VRK10.86934168
36TXK0.86783298
37ICK0.86536992
38TLK10.84877458
39CAMKK10.81983987
40PRKCD0.80336060
41CDK30.73461013
42ITK0.72043157
43MAPK150.71352747
44ZAP700.70497024
45NEK20.70306715
46MAP2K40.69230617
47LCK0.68331904
48PDPK10.68135975
49PINK10.67668356
50DAPK20.65832106
51CSF1R0.65817773
52ADRBK10.65808619
53TIE10.62935560
54BTK0.60816518
55STK110.60427419
56WNK30.59837402
57MAP2K60.58453684
58BCKDK0.57083720
59MAPK130.53509154
60GRK50.53352718
61PLK20.52033755
62EPHA30.50618015
63RPS6KA60.50356292
64SIK30.49853490
65KDR0.49442718
66LYN0.48918783
67IGF1R0.48195782
68PRKD30.47683195
69BRSK10.46973556
70CAMK10.46685651
71CSNK1D0.45113974
72DYRK20.42850487
73CSNK1G10.42605958
74PRKCQ0.42570907
75PRKG10.41641796
76TGFBR10.41493973
77EPHA40.40989403
78PRKCZ0.39807720
79GSK3A0.39725983
80MAP2K70.39712006
81INSRR0.39617588
82PRKCA0.38732324
83MARK30.38673773
84RPS6KA50.38073259
85MAP4K20.34912014
86AKT10.34807110
87PNCK0.34795326
88PRKACA0.34536414
89ABL10.33962614
90CAMK2A0.33757603
91HIPK20.32692369
92NEK60.32417266
93SIK20.32292330
94TAF10.31597145
95SGK20.31082196
96PRKACB0.29786406
97SGK4940.29671696
98SGK2230.29671696
99CDK60.29447033
100TAOK30.29440827

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.09219338
2African trypanosomiasis_Homo sapiens_hsa051432.93481906
3Allograft rejection_Homo sapiens_hsa053302.74254074
4RNA polymerase_Homo sapiens_hsa030202.71175700
5Primary immunodeficiency_Homo sapiens_hsa053402.61470849
6Protein export_Homo sapiens_hsa030602.22367712
7Type I diabetes mellitus_Homo sapiens_hsa049402.19749250
8Non-homologous end-joining_Homo sapiens_hsa034502.07527955
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06102301
10Phototransduction_Homo sapiens_hsa047442.05925310
11Linoleic acid metabolism_Homo sapiens_hsa005911.87884464
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83548519
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82061213
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79515209
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70672649
16Oxidative phosphorylation_Homo sapiens_hsa001901.62800523
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62650018
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57094680
19Nitrogen metabolism_Homo sapiens_hsa009101.55020845
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54814360
21Mineral absorption_Homo sapiens_hsa049781.53749267
22Cardiac muscle contraction_Homo sapiens_hsa042601.52625738
23Hematopoietic cell lineage_Homo sapiens_hsa046401.51344631
24Parkinsons disease_Homo sapiens_hsa050121.43607262
25Olfactory transduction_Homo sapiens_hsa047401.40717215
26Nicotine addiction_Homo sapiens_hsa050331.40260448
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.39859239
28Basal transcription factors_Homo sapiens_hsa030221.38429212
29Ether lipid metabolism_Homo sapiens_hsa005651.38362311
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37411509
31Measles_Homo sapiens_hsa051621.35748946
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.32735831
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21824686
34T cell receptor signaling pathway_Homo sapiens_hsa046601.21779672
35Malaria_Homo sapiens_hsa051441.19298650
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19179870
37Melanoma_Homo sapiens_hsa052181.12600664
38Taste transduction_Homo sapiens_hsa047421.12390868
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08177188
40Legionellosis_Homo sapiens_hsa051341.07979610
41Steroid biosynthesis_Homo sapiens_hsa001001.05193756
42RNA degradation_Homo sapiens_hsa030180.97937597
43Glutamatergic synapse_Homo sapiens_hsa047240.96207991
44Salivary secretion_Homo sapiens_hsa049700.94944233
45Systemic lupus erythematosus_Homo sapiens_hsa053220.94636890
46Alzheimers disease_Homo sapiens_hsa050100.92257474
47Dopaminergic synapse_Homo sapiens_hsa047280.90386022
48Fat digestion and absorption_Homo sapiens_hsa049750.87245230
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.86466594
50Epstein-Barr virus infection_Homo sapiens_hsa051690.85352248
51Huntingtons disease_Homo sapiens_hsa050160.84718005
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.84134422
53ABC transporters_Homo sapiens_hsa020100.84103731
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79964050
55Graft-versus-host disease_Homo sapiens_hsa053320.79439349
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.77311323
57Serotonergic synapse_Homo sapiens_hsa047260.76636813
58Arginine and proline metabolism_Homo sapiens_hsa003300.76301444
59Morphine addiction_Homo sapiens_hsa050320.76184556
60Platelet activation_Homo sapiens_hsa046110.73905565
61Peroxisome_Homo sapiens_hsa041460.71837228
62MAPK signaling pathway_Homo sapiens_hsa040100.70593348
63Butanoate metabolism_Homo sapiens_hsa006500.69055618
64Ribosome_Homo sapiens_hsa030100.67897286
65Arachidonic acid metabolism_Homo sapiens_hsa005900.67786060
66Circadian entrainment_Homo sapiens_hsa047130.67772184
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66922478
68Caffeine metabolism_Homo sapiens_hsa002320.66837668
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65440817
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64519469
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64412952
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63671209
73Pertussis_Homo sapiens_hsa051330.61827550
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60621784
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60590702
76B cell receptor signaling pathway_Homo sapiens_hsa046620.59790552
77Asthma_Homo sapiens_hsa053100.58203648
78Leishmaniasis_Homo sapiens_hsa051400.56237202
79Ras signaling pathway_Homo sapiens_hsa040140.56229188
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.54683548
81Autoimmune thyroid disease_Homo sapiens_hsa053200.52927532
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52637972
83Chemokine signaling pathway_Homo sapiens_hsa040620.52285119
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.50308392
85Pyrimidine metabolism_Homo sapiens_hsa002400.49611023
86Rheumatoid arthritis_Homo sapiens_hsa053230.48590149
87Insulin resistance_Homo sapiens_hsa049310.47987260
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47461320
89Renin secretion_Homo sapiens_hsa049240.46972399
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46200454
91Influenza A_Homo sapiens_hsa051640.44576823
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42497662
93Toxoplasmosis_Homo sapiens_hsa051450.42077063
94Cholinergic synapse_Homo sapiens_hsa047250.40692347
95Insulin secretion_Homo sapiens_hsa049110.40600041
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38719181
97Calcium signaling pathway_Homo sapiens_hsa040200.36273517
98TNF signaling pathway_Homo sapiens_hsa046680.35393258
99VEGF signaling pathway_Homo sapiens_hsa043700.34731631
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34009438

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