SUCLA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)7.36151189
2regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.34665227
3NADH metabolic process (GO:0006734)6.11119515
4regulation of acyl-CoA biosynthetic process (GO:0050812)6.10899925
5regulation of coenzyme metabolic process (GO:0051196)5.67498604
6regulation of cofactor metabolic process (GO:0051193)5.67498604
7carnitine shuttle (GO:0006853)5.35284458
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.26239951
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.10623620
10respiratory electron transport chain (GO:0022904)5.05905169
11fatty acid transmembrane transport (GO:1902001)5.00458021
12electron transport chain (GO:0022900)4.94684847
13lysine catabolic process (GO:0006554)4.84086405
14lysine metabolic process (GO:0006553)4.84086405
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63001018
16ATP synthesis coupled proton transport (GO:0015986)4.63001018
17regulation of sulfur metabolic process (GO:0042762)4.59369643
18regulation of sequestering of triglyceride (GO:0010889)4.50980293
19fatty acid beta-oxidation (GO:0006635)4.49488191
20* succinate metabolic process (GO:0006105)4.46985993
21carnitine transmembrane transport (GO:1902603)4.46078527
22aspartate family amino acid catabolic process (GO:0009068)4.38247152
23oxidative phosphorylation (GO:0006119)4.33779562
24carnitine transport (GO:0015879)4.32338073
25amino-acid betaine transport (GO:0015838)4.32338073
26oxaloacetate metabolic process (GO:0006107)4.16828410
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.16790142
28branched-chain amino acid catabolic process (GO:0009083)4.12547978
292-oxoglutarate metabolic process (GO:0006103)4.11308871
30fatty acid catabolic process (GO:0009062)4.03247124
31cellular ketone body metabolic process (GO:0046950)3.94875812
32acetyl-CoA metabolic process (GO:0006084)3.94208128
33fatty acid oxidation (GO:0019395)3.93431032
34regulation of fatty acid oxidation (GO:0046320)3.89647083
35negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.89597807
36lipid oxidation (GO:0034440)3.85937930
37DNA double-strand break processing (GO:0000729)3.81182270
38cullin deneddylation (GO:0010388)3.75938183
39regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.75704248
40short-chain fatty acid metabolic process (GO:0046459)3.66711981
41branched-chain amino acid metabolic process (GO:0009081)3.61727895
42regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.59633766
43biotin metabolic process (GO:0006768)3.58549754
44monocarboxylic acid catabolic process (GO:0072329)3.47312202
45IMP biosynthetic process (GO:0006188)3.44759426
46ATP biosynthetic process (GO:0006754)3.44624961
47quaternary ammonium group transport (GO:0015697)3.41599329
48protein deneddylation (GO:0000338)3.40806575
49carnitine metabolic process (GO:0009437)3.39666879
50sarcomere organization (GO:0045214)3.38911711
51tricarboxylic acid metabolic process (GO:0072350)3.38768962
52IMP metabolic process (GO:0046040)3.38653398
53ketone body metabolic process (GO:1902224)3.38129722
54regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.35993178
55proteasome assembly (GO:0043248)3.35834325
56sarcoplasmic reticulum calcium ion transport (GO:0070296)3.33972099
57negative regulation of potassium ion transmembrane transport (GO:1901380)3.31589279
58regulation of cell communication by electrical coupling (GO:0010649)3.29951036
59positive regulation of fatty acid oxidation (GO:0046321)3.28573666
60actin-myosin filament sliding (GO:0033275)3.28286801
61muscle filament sliding (GO:0030049)3.28286801
62regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.27213931
63amino-acid betaine metabolic process (GO:0006577)3.26486327
64inner mitochondrial membrane organization (GO:0007007)3.17827256
65respiratory chain complex IV assembly (GO:0008535)3.16863547
66establishment of integrated proviral latency (GO:0075713)3.16171948
67valine metabolic process (GO:0006573)3.14366468
68cardiac myofibril assembly (GO:0055003)3.12243565
69quinone biosynthetic process (GO:1901663)3.11591185
70ubiquinone biosynthetic process (GO:0006744)3.11591185
71gluconeogenesis (GO:0006094)3.04366398
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03758542
73cardiac muscle contraction (GO:0060048)3.00707197
74acyl-CoA biosynthetic process (GO:0071616)2.98336047
75thioester biosynthetic process (GO:0035384)2.98336047
76chromatin remodeling at centromere (GO:0031055)2.98324626
77regulation of triglyceride catabolic process (GO:0010896)2.97731914
78L-phenylalanine metabolic process (GO:0006558)2.95962232
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.95962232
80CENP-A containing nucleosome assembly (GO:0034080)2.95094586
81chaperone-mediated protein transport (GO:0072321)2.93556026
82hexose biosynthetic process (GO:0019319)2.93407978
83protein neddylation (GO:0045116)2.92282904
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91687427
85L-phenylalanine catabolic process (GO:0006559)2.91687427
86myofibril assembly (GO:0030239)2.91044756
87regulation of helicase activity (GO:0051095)2.89716045
88ribosome assembly (GO:0042255)2.89528729
89negative regulation of DNA recombination (GO:0045910)2.88939612
90glyoxylate metabolic process (GO:0046487)2.88687272
91regulation of skeletal muscle contraction (GO:0014819)2.86886781
92somatic hypermutation of immunoglobulin genes (GO:0016446)2.86361726
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86361726
94purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85891608
95negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85734164
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85560882
97fatty acid homeostasis (GO:0055089)2.84887921
98aerobic respiration (GO:0009060)2.84767985
99NAD metabolic process (GO:0019674)2.83407813
100pyruvate metabolic process (GO:0006090)2.83385379
101purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.83309136
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.82852260
103regulation of relaxation of muscle (GO:1901077)2.81666656
104maturation of 5.8S rRNA (GO:0000460)2.77429351
105negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76729314
106regulation of oxidative phosphorylation (GO:0002082)2.76002712
107protein complex biogenesis (GO:0070271)2.75395655
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.74415877
109organic acid catabolic process (GO:0016054)2.74124026
110carboxylic acid catabolic process (GO:0046395)2.74124026
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73592891
112* acyl-CoA metabolic process (GO:0006637)2.73369454
113* thioester metabolic process (GO:0035383)2.73369454
114lipid particle organization (GO:0034389)2.73347701
115hydrogen ion transmembrane transport (GO:1902600)2.72898931
116ventricular cardiac muscle cell action potential (GO:0086005)2.72280261
117mitochondrial respiratory chain complex assembly (GO:0033108)2.71996822
118regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.71630579
119ubiquinone metabolic process (GO:0006743)2.70367637
120regulation of fatty acid metabolic process (GO:0019217)2.69939301
121generation of precursor metabolites and energy (GO:0006091)2.68794907
122establishment of protein localization to mitochondrial membrane (GO:0090151)2.68062098
123DNA damage response, detection of DNA damage (GO:0042769)2.67723596
124actin-mediated cell contraction (GO:0070252)2.67020410
125DNA ligation (GO:0006266)2.66915489
126glycogen catabolic process (GO:0005980)2.66401647
127cytochrome complex assembly (GO:0017004)2.65852820
128neuronal action potential propagation (GO:0019227)2.65756996
129C4-dicarboxylate transport (GO:0015740)2.65618045
130regulation of membrane repolarization (GO:0060306)2.65437583
131histone exchange (GO:0043486)2.65157989
132peptidyl-cysteine modification (GO:0018198)2.64306926
133attachment of spindle microtubules to kinetochore (GO:0008608)2.64228938
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62445485
135regulation of mitochondrial translation (GO:0070129)2.60517888
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.59071532
137NADH dehydrogenase complex assembly (GO:0010257)2.59071532
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59071532
139L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57659946
140non-recombinational repair (GO:0000726)2.57557000
141double-strand break repair via nonhomologous end joining (GO:0006303)2.57557000
142negative regulation of ligase activity (GO:0051352)2.55873308
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55873308
144regulation of actin filament-based movement (GO:1903115)2.53480002
145regulation of mitotic spindle checkpoint (GO:1903504)2.53451031
146regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53451031
147establishment of viral latency (GO:0019043)2.52113481
148cardiac muscle cell development (GO:0055013)2.51915582
149purine nucleobase biosynthetic process (GO:0009113)2.50972944
150heart contraction (GO:0060047)2.49417560
151heart process (GO:0003015)2.49417560
152DNA catabolic process, exonucleolytic (GO:0000738)2.46908496
153positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.43682134
154histone H2A acetylation (GO:0043968)2.43136993
155regulation of cellular amino acid metabolic process (GO:0006521)2.43034773
156lactate metabolic process (GO:0006089)2.41846336
157cellular respiration (GO:0045333)2.41211395
158mitotic spindle checkpoint (GO:0071174)2.39900896
159protein K6-linked ubiquitination (GO:0085020)2.39254356
160positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.39173444
161spindle checkpoint (GO:0031577)2.39106122
162regulation of glucokinase activity (GO:0033131)2.38348174
163regulation of hexokinase activity (GO:1903299)2.38348174
164DNA replication checkpoint (GO:0000076)2.34569599
165mitotic metaphase plate congression (GO:0007080)2.34223906
166water-soluble vitamin biosynthetic process (GO:0042364)2.33268652
167regulation of meiosis I (GO:0060631)2.33098140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.87732571
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.02698396
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.28318740
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.88789736
5* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.70293195
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.13538658
7EZH2_22144423_ChIP-Seq_EOC_Human2.96791265
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.80422294
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.76413721
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.61929005
11IGF1R_20145208_ChIP-Seq_DFB_Human2.58759089
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.55777710
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.52533972
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.50124979
15E2F7_22180533_ChIP-Seq_HELA_Human2.40403564
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.28948829
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24434717
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23787486
19ELK1_19687146_ChIP-ChIP_HELA_Human2.19992733
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16209399
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13869045
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08554345
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08132532
24GBX2_23144817_ChIP-Seq_PC3_Human2.02588121
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97311274
26EWS_26573619_Chip-Seq_HEK293_Human1.97197945
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95720496
28* EP300_21415370_ChIP-Seq_HL-1_Mouse1.94267312
29TAF15_26573619_Chip-Seq_HEK293_Human1.93143647
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87024651
31ZNF263_19887448_ChIP-Seq_K562_Human1.76029986
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75127481
33VDR_22108803_ChIP-Seq_LS180_Human1.72705452
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68329605
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.67524416
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62662625
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57144228
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.55042420
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53945581
40VDR_23849224_ChIP-Seq_CD4+_Human1.53639885
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50105767
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49528406
43* ZNF274_21170338_ChIP-Seq_K562_Hela1.48822390
44AR_21909140_ChIP-Seq_LNCAP_Human1.40875867
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40303382
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38471412
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38401592
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32771214
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31856846
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30802528
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30378358
52FOXP3_21729870_ChIP-Seq_TREG_Human1.28517599
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.28462495
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27062647
55BCAT_22108803_ChIP-Seq_LS180_Human1.26086480
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25782483
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.25771334
58* REST_21632747_ChIP-Seq_MESCs_Mouse1.24930310
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24874180
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.24496720
61CBP_20019798_ChIP-Seq_JUKART_Human1.23640643
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23640643
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23132187
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22097783
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21572693
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21537901
67HTT_18923047_ChIP-ChIP_STHdh_Human1.21265510
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20097987
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19684183
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19285612
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19199837
72* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19028753
73SMAD4_21799915_ChIP-Seq_A2780_Human1.18245003
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17874533
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17381562
76DCP1A_22483619_ChIP-Seq_HELA_Human1.17115175
77MYC_18940864_ChIP-ChIP_HL60_Human1.16897130
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.15468452
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13916810
80* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13811737
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13469614
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.13190056
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.13190056
84* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12526821
85* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11508489
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09370103
87CLOCK_20551151_ChIP-Seq_293T_Human1.08643577
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08565495
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07732216
90ER_23166858_ChIP-Seq_MCF-7_Human1.07526641
91AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07353410
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.05947633
93* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05576116
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05507507
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05028765
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04396041
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.04079631
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04003749
99SOX2_16153702_ChIP-ChIP_HESCs_Human1.02946946
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.02601093
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.02443619
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01965957
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00874556
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00319142
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99818916
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99062587
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98900870
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98331931
109MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98289178
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98159209
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98151328
112P53_22387025_ChIP-Seq_ESCs_Mouse0.97631775
113NANOG_19829295_ChIP-Seq_ESCs_Human0.96941861
114SOX2_19829295_ChIP-Seq_ESCs_Human0.96941861
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96688485
116* P300_19829295_ChIP-Seq_ESCs_Human0.96429027
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95937617
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95860915
119AR_25329375_ChIP-Seq_VCAP_Human0.95855999
120RARB_27405468_Chip-Seq_BRAIN_Mouse0.94676520
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94478394
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94150760
123MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93941775
124SOX2_21211035_ChIP-Seq_LN229_Gbm0.93619453
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93367066
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.92842472
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92301280
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92198689
129TP53_22573176_ChIP-Seq_HFKS_Human0.92099923
130P300_18555785_Chip-Seq_ESCs_Mouse0.90786266
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90712691
132PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90252747
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89447543
134MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88185663
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86284146
136MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86133652
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85930354
138RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85487357
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84185968
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82823352
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82067528
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82067528
143FUS_26573619_Chip-Seq_HEK293_Human0.81586347
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.81562892
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.79811108
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77914242
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77838303
148SMAD3_21741376_ChIP-Seq_EPCs_Human0.77829669
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76875208
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75535017
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.74881734
152EZH2_18974828_ChIP-Seq_MESCs_Mouse0.74797785
153RNF2_18974828_ChIP-Seq_MESCs_Mouse0.74797785
154SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.74465911
155FOXH1_21741376_ChIP-Seq_ESCs_Human0.74463674
156* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.73744217
157REST_19997604_ChIP-ChIP_NEURONS_Mouse0.73733862
158SRF_21415370_ChIP-Seq_HL-1_Mouse0.73136747
159TCF4_22108803_ChIP-Seq_LS180_Human0.72956502
160CBP_21632823_ChIP-Seq_H3396_Human0.72914011
161* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72813503

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.81811739
2MP0003646_muscle_fatigue4.65855152
3MP0000751_myopathy3.50292058
4MP0004215_abnormal_myocardial_fiber3.04148750
5MP0004130_abnormal_muscle_cell3.03794759
6MP0004084_abnormal_cardiac_muscle3.02627537
7MP0006036_abnormal_mitochondrial_physio2.95899279
8MP0000749_muscle_degeneration2.91294482
9MP0004036_abnormal_muscle_relaxation2.90623700
10MP0005360_urolithiasis2.83592857
11MP0002139_abnormal_hepatobiliary_system2.82949020
12MP0005085_abnormal_gallbladder_physiolo2.68120009
13MP0005330_cardiomyopathy2.59255314
14MP0008877_abnormal_DNA_methylation2.34692396
15MP0005670_abnormal_white_adipose2.29668205
16MP0008058_abnormal_DNA_repair2.29622231
17MP0005365_abnormal_bile_salt2.24620491
18MP0004145_abnormal_muscle_electrophysio2.19564103
19MP0003806_abnormal_nucleotide_metabolis2.07649856
20MP0010094_abnormal_chromosome_stability2.07537323
21MP0005620_abnormal_muscle_contractility2.04769304
22MP0006035_abnormal_mitochondrial_morpho1.99229065
23MP0004087_abnormal_muscle_fiber1.97763533
24MP0005332_abnormal_amino_acid1.96322686
25MP0003941_abnormal_skin_development1.95863118
26MP0008875_abnormal_xenobiotic_pharmacok1.94640627
27MP0004484_altered_response_of1.91369218
28MP0002972_abnormal_cardiac_muscle1.89917749
29MP0002269_muscular_atrophy1.86901465
30MP0002822_catalepsy1.86691542
31MP0002102_abnormal_ear_morphology1.83944358
32MP0005666_abnormal_adipose_tissue1.83324949
33MP0000747_muscle_weakness1.77650915
34MP0003195_calcinosis1.74221398
35MP0008775_abnormal_heart_ventricle1.72856744
36MP0002332_abnormal_exercise_endurance1.70434290
37MP0000013_abnormal_adipose_tissue1.69933781
38MP0002106_abnormal_muscle_physiology1.68236034
39MP0005535_abnormal_body_temperature1.67989569
40MP0004957_abnormal_blastocyst_morpholog1.67948450
41MP0003693_abnormal_embryo_hatching1.66642246
42MP0004233_abnormal_muscle_weight1.65330420
43MP0010329_abnormal_lipoprotein_level1.65051826
44MP0002971_abnormal_brown_adipose1.64677372
45MP0006072_abnormal_retinal_apoptosis1.62465256
46MP0004043_abnormal_pH_regulation1.60780605
47MP0003137_abnormal_impulse_conducting1.59708276
48MP0002638_abnormal_pupillary_reflex1.58132723
49MP0006138_congestive_heart_failure1.57893609
50MP0001544_abnormal_cardiovascular_syste1.57502855
51MP0005385_cardiovascular_system_phenoty1.57502855
52MP0001984_abnormal_olfaction1.56855481
53MP0005410_abnormal_fertilization1.53211767
54MP0003221_abnormal_cardiomyocyte_apopto1.52752400
55MP0003890_abnormal_embryonic-extraembry1.51652996
56MP0008057_abnormal_DNA_replication1.49067022
57MP0004085_abnormal_heartbeat1.46772692
58MP0000759_abnormal_skeletal_muscle1.44186869
59MP0000750_abnormal_muscle_regeneration1.44117201
60MP0003880_abnormal_central_pattern1.41374288
61MP0005369_muscle_phenotype1.38813512
62MP0009046_muscle_twitch1.35394845
63MP0002118_abnormal_lipid_homeostasis1.35033331
64MP0008932_abnormal_embryonic_tissue1.33888283
65MP0003718_maternal_effect1.32791218
66MP0005584_abnormal_enzyme/coenzyme_acti1.32549267
67MP0004859_abnormal_synaptic_plasticity1.27109052
68MP0003121_genomic_imprinting1.26387643
69MP0003122_maternal_imprinting1.21936093
70MP0005266_abnormal_metabolism1.18656699
71MP0003186_abnormal_redox_activity1.17934281
72MP0004147_increased_porphyrin_level1.17337400
73MP0003787_abnormal_imprinting1.17188673
74MP0004270_analgesia1.17003512
75MP0003111_abnormal_nucleus_morphology1.14615116
76MP0003329_amyloid_beta_deposits1.13619261
77MP0010630_abnormal_cardiac_muscle1.13593281
78MP0009745_abnormal_behavioral_response1.13127944
79MP0002735_abnormal_chemical_nociception1.11646451
80MP0005253_abnormal_eye_physiology1.11581396
81MP0003567_abnormal_fetal_cardiomyocyte1.11440382
82MP0005375_adipose_tissue_phenotype1.10360263
83MP0002078_abnormal_glucose_homeostasis1.10276250
84MP0005319_abnormal_enzyme/_coenzyme1.10057020
85MP0001486_abnormal_startle_reflex1.09677612
86MP0003635_abnormal_synaptic_transmissio1.06855780
87MP0000230_abnormal_systemic_arterial1.04122344
88MP0006276_abnormal_autonomic_nervous1.04108766
89MP0001177_atelectasis1.02108734
90MP0005551_abnormal_eye_electrophysiolog1.01576378
91MP0004185_abnormal_adipocyte_glucose1.01106656
92MP0005423_abnormal_somatic_nervous1.01013490
93MP0004924_abnormal_behavior1.00815230
94MP0005386_behavior/neurological_phenoty1.00815230
95MP0001968_abnormal_touch/_nociception0.99970903
96MP0003252_abnormal_bile_duct0.99810358
97MP0002876_abnormal_thyroid_physiology0.99412563
98MP0001440_abnormal_grooming_behavior0.97063656
99MP0003077_abnormal_cell_cycle0.96340469
100MP0008007_abnormal_cellular_replicative0.96073978
101MP0002736_abnormal_nociception_after0.95706318
102MP0002064_seizures0.95700031
103MP0002909_abnormal_adrenal_gland0.93892829
104MP0002938_white_spotting0.93707601
105MP0005083_abnormal_biliary_tract0.91581296
106MP0001299_abnormal_eye_distance/0.91382945
107MP0002272_abnormal_nervous_system0.90621250
108MP0003937_abnormal_limbs/digits/tail_de0.90253874
109MP0002234_abnormal_pharynx_morphology0.89723637
110MP0001529_abnormal_vocalization0.89597154
111MP0001293_anophthalmia0.89385279
112MP0002090_abnormal_vision0.89049729
113MP0002063_abnormal_learning/memory/cond0.85872641
114MP0003119_abnormal_digestive_system0.84304935
115MP0005187_abnormal_penis_morphology0.82957090
116MP0001764_abnormal_homeostasis0.81825030
117MP0005448_abnormal_energy_balance0.80430892
118MP0004142_abnormal_muscle_tone0.79932707
119MP0002067_abnormal_sensory_capabilities0.79593882
120MP0009697_abnormal_copulation0.79020091
121MP0000609_abnormal_liver_physiology0.78345404
122MP0003786_premature_aging0.77556466
123MP0004019_abnormal_vitamin_homeostasis0.76989702
124MP0002127_abnormal_cardiovascular_syste0.76580346
125MP0002751_abnormal_autonomic_nervous0.76161350
126MP0005334_abnormal_fat_pad0.75947769
127MP0002233_abnormal_nose_morphology0.75472653
128MP0008789_abnormal_olfactory_epithelium0.74701446
129MP0001730_embryonic_growth_arrest0.74418016
130MP0001661_extended_life_span0.74359864
131MP0002734_abnormal_mechanical_nocicepti0.74084970
132MP0003950_abnormal_plasma_membrane0.73677230
133MP0000003_abnormal_adipose_tissue0.73008390
134MP0006292_abnormal_olfactory_placode0.72973187
135MP0005367_renal/urinary_system_phenotyp0.72920822
136MP0000516_abnormal_urinary_system0.72920822
137MP0009780_abnormal_chondrocyte_physiolo0.72868496
138MP0005646_abnormal_pituitary_gland0.72267561
139MP0001666_abnormal_nutrient_absorption0.72213610
140MP0009672_abnormal_birth_weight0.71896067
141MP0001485_abnormal_pinna_reflex0.70669182
142MP0009643_abnormal_urine_homeostasis0.70527905
143MP0005451_abnormal_body_composition0.70385355
144MP0002572_abnormal_emotion/affect_behav0.70313075
145MP0001501_abnormal_sleep_pattern0.69142137
146MP0005636_abnormal_mineral_homeostasis0.68731515
147MP0001188_hyperpigmentation0.68445594
148MP0009840_abnormal_foam_cell0.68225807

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.94068351
2Myoglobinuria (HP:0002913)4.92807660
3Abnormal mitochondria in muscle tissue (HP:0008316)4.59399578
4Acute necrotizing encephalopathy (HP:0006965)4.55185040
5Hepatic necrosis (HP:0002605)4.52529954
6Acute encephalopathy (HP:0006846)4.40262774
7Exercise-induced muscle cramps (HP:0003710)4.08400345
8Cerebral edema (HP:0002181)4.04545632
9Rhabdomyolysis (HP:0003201)4.00881238
10Hepatocellular necrosis (HP:0001404)3.93822046
11Progressive macrocephaly (HP:0004481)3.89870936
12Hypoglycemic coma (HP:0001325)3.88164628
13Sudden death (HP:0001699)3.86677998
14Abnormality of fatty-acid metabolism (HP:0004359)3.86215183
15Mitochondrial inheritance (HP:0001427)3.71008088
16Hyperglycinuria (HP:0003108)3.68431383
17Increased CSF lactate (HP:0002490)3.67132995
18Increased serum pyruvate (HP:0003542)3.65699834
19Abnormality of glycolysis (HP:0004366)3.65699834
20Calf muscle hypertrophy (HP:0008981)3.55446373
21Abnormality of alanine metabolism (HP:0010916)3.54433544
22Hyperalaninemia (HP:0003348)3.54433544
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.54433544
24Ketoacidosis (HP:0001993)3.50336550
25Muscle hypertrophy of the lower extremities (HP:0008968)3.49602441
26Increased muscle lipid content (HP:0009058)3.45468699
27Pheochromocytoma (HP:0002666)3.43256231
28* Dicarboxylic aciduria (HP:0003215)3.36384653
29* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.36384653
30* Lactic acidosis (HP:0003128)3.35420639
31Ketosis (HP:0001946)3.32717548
32Hyperammonemia (HP:0001987)3.28085775
33Palpitations (HP:0001962)3.25603222
34Abnormality of glycine metabolism (HP:0010895)3.22199108
35Abnormality of serine family amino acid metabolism (HP:0010894)3.22199108
36Neuroendocrine neoplasm (HP:0100634)3.15573117
37Generalized aminoaciduria (HP:0002909)3.07623827
38Increased intramyocellular lipid droplets (HP:0012240)2.97977106
39Lethargy (HP:0001254)2.96772568
40Muscle fiber splitting (HP:0003555)2.94620604
41Hyperglycinemia (HP:0002154)2.92048788
42Abnormality of the labia minora (HP:0012880)2.89908765
43Muscle stiffness (HP:0003552)2.86718357
44Colon cancer (HP:0003003)2.86301982
45Abnormality of the calf musculature (HP:0001430)2.78832877
46Rimmed vacuoles (HP:0003805)2.78533995
47Exercise intolerance (HP:0003546)2.78483703
48Respiratory failure (HP:0002878)2.77912052
49Hyporeflexia of lower limbs (HP:0002600)2.77203753
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.76069325
51Type 1 muscle fiber predominance (HP:0003803)2.70601314
52Ventricular tachycardia (HP:0004756)2.64836820
53Proximal tubulopathy (HP:0000114)2.61951474
54Conjunctival hamartoma (HP:0100780)2.58933126
55Atrial fibrillation (HP:0005110)2.57103771
56Ragged-red muscle fibers (HP:0003200)2.56521886
57Metabolic acidosis (HP:0001942)2.55518712
58Bundle branch block (HP:0011710)2.54056173
59Muscle fiber inclusion bodies (HP:0100299)2.53958425
60Difficulty running (HP:0009046)2.53815730
61Syncope (HP:0001279)2.52021807
62Distal arthrogryposis (HP:0005684)2.48729311
63Oligomenorrhea (HP:0000876)2.48035627
64Lipid accumulation in hepatocytes (HP:0006561)2.44793293
65Abnormality of serum amino acid levels (HP:0003112)2.44482364
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.44456656
67Myotonia (HP:0002486)2.43724273
68Increased serum lactate (HP:0002151)2.41002712
69Lipoatrophy (HP:0100578)2.40234753
70Primary atrial arrhythmia (HP:0001692)2.35746361
71Vomiting (HP:0002013)2.33045327
72EMG: myopathic abnormalities (HP:0003458)2.29802282
73Hypoalphalipoproteinemia (HP:0003233)2.27523603
74Renal cortical cysts (HP:0000803)2.27462519
75Hyperventilation (HP:0002883)2.26652418
76Supraventricular tachycardia (HP:0004755)2.26037434
77Nemaline bodies (HP:0003798)2.25390214
78Nausea (HP:0002018)2.24502484
79Ventricular fibrillation (HP:0001663)2.23382118
80Dilated cardiomyopathy (HP:0001644)2.22584022
81CNS demyelination (HP:0007305)2.21923488
82Optic disc pallor (HP:0000543)2.21197468
83Supraventricular arrhythmia (HP:0005115)2.19919393
84Ependymoma (HP:0002888)2.19770333
85Asymmetric septal hypertrophy (HP:0001670)2.18797459
86Neck muscle weakness (HP:0000467)2.18263811
87Gout (HP:0001997)2.14696187
88Increased connective tissue (HP:0009025)2.13341190
89Leukodystrophy (HP:0002415)2.10108600
90Prolonged QT interval (HP:0001657)2.08863623
91Focal motor seizures (HP:0011153)2.06870702
92Ventricular arrhythmia (HP:0004308)2.06511510
93Hyperinsulinemic hypoglycemia (HP:0000825)2.06337567
94Right ventricular cardiomyopathy (HP:0011663)2.06326283
95Type I transferrin isoform profile (HP:0003642)2.05960213
96Heart block (HP:0012722)2.05618950
97Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03573856
98Glycosuria (HP:0003076)2.03217544
99Abnormality of urine glucose concentration (HP:0011016)2.03217544
100Hypolipoproteinemia (HP:0010981)2.02773519
101Cholelithiasis (HP:0001081)1.98285377
102Hyperuricemia (HP:0002149)1.96577343
103Increased purine levels (HP:0004368)1.96577343
104Cerebral hemorrhage (HP:0001342)1.96287094
105Neoplasm of the adrenal gland (HP:0100631)1.93402172
106Atrioventricular block (HP:0001678)1.93267370
107Areflexia of lower limbs (HP:0002522)1.92844296
108Neoplasm of head and neck (HP:0012288)1.92576261
109Esophageal neoplasm (HP:0100751)1.92576261
110Increased hepatocellular lipid droplets (HP:0006565)1.92322260
111Hypoglycemic seizures (HP:0002173)1.87920512
112Cerebral hypomyelination (HP:0006808)1.87762854
113Medial flaring of the eyebrow (HP:0010747)1.86418374
114Abnormality of the hip-girdle musculature (HP:0001445)1.83732634
115Abnormality of the musculature of the pelvis (HP:0001469)1.83732634
116Agnosia (HP:0010524)1.83109479
117Myopathic facies (HP:0002058)1.82490392
118Reduced antithrombin III activity (HP:0001976)1.78344467
119Atonic seizures (HP:0010819)1.78318778
120Abnormality of methionine metabolism (HP:0010901)1.77937743
121Gonadotropin excess (HP:0000837)1.75361032
122Shoulder girdle muscle weakness (HP:0003547)1.75286893
123Absent phalangeal crease (HP:0006109)1.74973050
124Pancreatic islet-cell hyperplasia (HP:0004510)1.73118425
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72972017
126Abnormality of the astrocytes (HP:0100707)1.72967220
127Astrocytoma (HP:0009592)1.72967220
128Medulloblastoma (HP:0002885)1.72544728
129Abnormality of the left ventricular outflow tract (HP:0011103)1.72026503
130Subaortic stenosis (HP:0001682)1.72026503
131Glioma (HP:0009733)1.70300334
132Impaired vibration sensation in the lower limbs (HP:0002166)1.69327753
133Meckel diverticulum (HP:0002245)1.69107087
134Volvulus (HP:0002580)1.66389331
135Round ear (HP:0100830)1.65345854
136Neoplasm of the small intestine (HP:0100833)1.65336887
137Rhabdomyosarcoma (HP:0002859)1.65238687
138Gait imbalance (HP:0002141)1.64799628
139Abnormality of chromosome stability (HP:0003220)1.63725554
140Abnormal finger flexion creases (HP:0006143)1.62507727
141Abnormal protein glycosylation (HP:0012346)1.62395369
142Abnormal glycosylation (HP:0012345)1.62395369
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62395369
144Abnormal protein N-linked glycosylation (HP:0012347)1.62395369
145Congenital primary aphakia (HP:0007707)1.62388087
146Calcaneovalgus deformity (HP:0001848)1.61790923
147Proximal amyotrophy (HP:0007126)1.61428231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.41577827
2PDK36.41577827
3PDK23.98779174
4BCKDK3.82321132
5OBSCN3.24793399
6BUB12.70253008
7PINK12.57371818
8PHKG12.51190410
9PHKG22.51190410
10TRIM282.46254324
11NEK12.36547037
12TTN2.33077781
13LMTK22.26716535
14MKNK12.10971530
15EIF2AK32.08580932
16MKNK22.08548517
17MYLK2.06886502
18SRPK11.99098843
19PBK1.94406988
20MAP2K41.92592965
21PLK31.87378212
22MAP4K21.85469428
23MAP3K41.80071506
24MST41.75151269
25PLK41.72850277
26ERBB31.72355216
27TTK1.72095310
28WNK41.69320325
29NTRK31.52292424
30TNIK1.52274352
31CASK1.50588998
32NME11.49587605
33MAP3K121.44222883
34ZAK1.39717203
35MAP2K71.36851567
36NUAK11.36549742
37CDC71.34728606
38VRK21.34571889
39STK161.31389300
40CSNK1G21.25102879
41STK38L1.23593322
42ACVR1B1.21939661
43STK391.18908744
44CSNK1G11.18783859
45MINK11.14470502
46CSNK1G31.13812809
47WEE11.13191455
48STK241.09541148
49BMPR1B1.06958789
50EPHA41.06850127
51AKT31.06230324
52PLK11.05587579
53PTK2B1.04211704
54ARAF1.03379520
55MAPK130.98290057
56PIK3CA0.97999702
57GRK70.97021533
58TRIB30.96549497
59TIE10.96324008
60MUSK0.96015325
61DAPK20.94524045
62INSRR0.94422271
63VRK10.94070079
64PLK20.92425292
65CSNK1A1L0.91046493
66MAP3K90.91002150
67TAF10.88888783
68BRSK20.88043548
69CAMK2D0.87937598
70CCNB10.87631694
71PRKD30.85737949
72GRK50.84262520
73OXSR10.83376657
74CAMK2G0.82950504
75KSR20.82562240
76GRK10.80971207
77STK380.78087463
78CAMK2A0.76754929
79MAP2K10.72559940
80MAPK120.70655161
81PRKAA10.68947682
82PAK30.68794278
83NEK90.67928850
84EIF2AK20.67362777
85PRKAA20.66345368
86PDK10.65444951
87NEK20.65409434
88PRKCG0.64794628
89PDPK10.64381959
90CDK190.63453404
91PKN20.62217728
92BCR0.61653976
93MAP2K60.61152727
94KSR10.60962261
95SGK2230.60228060
96SGK4940.60228060
97SGK20.59021715
98BRSK10.58553968
99MAPKAPK50.58518267
100PNCK0.57672162
101WNK10.56861288
102LATS20.54576175
103PIK3CG0.54114663
104AURKB0.51760500
105BRAF0.51754206
106WNK30.51528215
107PRKACA0.50082110
108UHMK10.50003202
109FRK0.48929045
110PRKACG0.48866096
111MAP3K50.48439615
112DYRK20.48281064
113DAPK10.47957510
114CAMK2B0.45914314
115ATM0.45571321
116ATR0.44944490
117FGFR10.44666379
118MAP3K70.44546487
119MAPKAPK30.44375921
120CAMKK20.42479279
121PAK60.41797940
122PRKCE0.41668129
123FER0.40801939
124DYRK30.40450539
125CDK180.39789935
126SGK30.39744799
127PRPF4B0.39047842
128ROCK20.38934533
129CSNK1E0.38801427
130STK30.38226217
131CSNK1A10.38111700
132CDK50.37992971
133CDK140.37345241
134PRKACB0.36112158
135CAMK10.35944486
136ILK0.35576624
137FGFR20.34921844
138ALK0.34097457
139MARK10.34092568
140CHEK20.33636289
141ERBB40.32675986
142ROCK10.32640802
143DMPK0.31592079
144DAPK30.31275182
145NTRK10.28772385
146EIF2AK10.28727553
147MAP2K30.28521107
148ADRBK10.25376165
149TSSK60.25282367
150LIMK10.24834267
151SGK10.23994376
152PKN10.23801304
153RPS6KA30.22428698

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.21215349
2* Propanoate metabolism_Homo sapiens_hsa006403.76978833
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.54659060
4Fatty acid degradation_Homo sapiens_hsa000713.08670344
5Oxidative phosphorylation_Homo sapiens_hsa001903.01373029
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.95005513
7Pyruvate metabolism_Homo sapiens_hsa006202.87532446
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78957887
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.76831578
10Parkinsons disease_Homo sapiens_hsa050122.72867120
11Fatty acid metabolism_Homo sapiens_hsa012122.60400298
12* Carbon metabolism_Homo sapiens_hsa012002.48266736
13Protein export_Homo sapiens_hsa030602.30040292
14Mismatch repair_Homo sapiens_hsa034302.26580007
15Butanoate metabolism_Homo sapiens_hsa006502.24416291
16Cardiac muscle contraction_Homo sapiens_hsa042602.18697578
17Non-homologous end-joining_Homo sapiens_hsa034502.11524237
18Alzheimers disease_Homo sapiens_hsa050102.04552888
19Huntingtons disease_Homo sapiens_hsa050161.84861920
20Fatty acid elongation_Homo sapiens_hsa000621.84263903
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82026446
22PPAR signaling pathway_Homo sapiens_hsa033201.76952566
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74255257
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74065834
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72701993
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68710379
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62300735
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61457613
29DNA replication_Homo sapiens_hsa030301.57403040
30Tryptophan metabolism_Homo sapiens_hsa003801.49681664
31RNA polymerase_Homo sapiens_hsa030201.48560049
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.48366314
33Peroxisome_Homo sapiens_hsa041461.43730041
34Homologous recombination_Homo sapiens_hsa034401.42184826
35Arginine biosynthesis_Homo sapiens_hsa002201.40949147
36Basal transcription factors_Homo sapiens_hsa030221.40434812
37Fanconi anemia pathway_Homo sapiens_hsa034601.38975476
38Biosynthesis of amino acids_Homo sapiens_hsa012301.38938271
39beta-Alanine metabolism_Homo sapiens_hsa004101.35799091
40RNA degradation_Homo sapiens_hsa030181.31531925
41Nucleotide excision repair_Homo sapiens_hsa034201.27132113
42RNA transport_Homo sapiens_hsa030131.26099692
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18082797
44Oocyte meiosis_Homo sapiens_hsa041141.17036422
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16214434
46One carbon pool by folate_Homo sapiens_hsa006701.13763798
47Base excision repair_Homo sapiens_hsa034101.13073385
48Fatty acid biosynthesis_Homo sapiens_hsa000611.09141642
49Steroid biosynthesis_Homo sapiens_hsa001001.05993799
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04194508
51Purine metabolism_Homo sapiens_hsa002301.03951466
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02616159
53Nitrogen metabolism_Homo sapiens_hsa009101.02468434
54Glucagon signaling pathway_Homo sapiens_hsa049221.02404653
55Sulfur metabolism_Homo sapiens_hsa009201.02013696
56Circadian rhythm_Homo sapiens_hsa047101.01694813
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01245379
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.97843144
59Starch and sucrose metabolism_Homo sapiens_hsa005000.96560679
60Phenylalanine metabolism_Homo sapiens_hsa003600.94611335
61Vitamin B6 metabolism_Homo sapiens_hsa007500.90190732
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86076384
63Dilated cardiomyopathy_Homo sapiens_hsa054140.86075793
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84413688
65Cell cycle_Homo sapiens_hsa041100.83019745
66Glycerolipid metabolism_Homo sapiens_hsa005610.82565636
67Collecting duct acid secretion_Homo sapiens_hsa049660.81926845
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81751794
69Spliceosome_Homo sapiens_hsa030400.81361393
70Pyrimidine metabolism_Homo sapiens_hsa002400.76673472
71Fructose and mannose metabolism_Homo sapiens_hsa000510.76242988
72Tyrosine metabolism_Homo sapiens_hsa003500.75897876
73Synaptic vesicle cycle_Homo sapiens_hsa047210.73387447
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70533190
75Bile secretion_Homo sapiens_hsa049760.70198143
76Phototransduction_Homo sapiens_hsa047440.69847996
77Fat digestion and absorption_Homo sapiens_hsa049750.67289915
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65556753
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64884057
80* Metabolic pathways_Homo sapiens_hsa011000.63107329
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62844544
82Pentose phosphate pathway_Homo sapiens_hsa000300.61216407
83Nicotine addiction_Homo sapiens_hsa050330.57772531
84Arginine and proline metabolism_Homo sapiens_hsa003300.56329079
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56009701
86mRNA surveillance pathway_Homo sapiens_hsa030150.54481735
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.53698225
88Renin secretion_Homo sapiens_hsa049240.52595437
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52166460
90Calcium signaling pathway_Homo sapiens_hsa040200.52093031
91Insulin signaling pathway_Homo sapiens_hsa049100.51413518
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48879451
93Chemical carcinogenesis_Homo sapiens_hsa052040.46834812
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46014755
95AMPK signaling pathway_Homo sapiens_hsa041520.44218772
96Tight junction_Homo sapiens_hsa045300.43836377
97Regulation of autophagy_Homo sapiens_hsa041400.43678388
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43642124
99Proteasome_Homo sapiens_hsa030500.43389685
100Circadian entrainment_Homo sapiens_hsa047130.42307899
101Galactose metabolism_Homo sapiens_hsa000520.41501676
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40712568
103Histidine metabolism_Homo sapiens_hsa003400.40282553
104GABAergic synapse_Homo sapiens_hsa047270.39945014
105Complement and coagulation cascades_Homo sapiens_hsa046100.39709987
106Amphetamine addiction_Homo sapiens_hsa050310.38995952
107Insulin resistance_Homo sapiens_hsa049310.38912851
108Insulin secretion_Homo sapiens_hsa049110.37666801
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37553895
110Long-term potentiation_Homo sapiens_hsa047200.36571441
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.35760842
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35481871
113Oxytocin signaling pathway_Homo sapiens_hsa049210.34574060
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.34448438
115Selenocompound metabolism_Homo sapiens_hsa004500.34121859
116Glutamatergic synapse_Homo sapiens_hsa047240.33649833
117Retinol metabolism_Homo sapiens_hsa008300.33226340
118Olfactory transduction_Homo sapiens_hsa047400.33141756
119Gastric acid secretion_Homo sapiens_hsa049710.32974115
120Taste transduction_Homo sapiens_hsa047420.31777657
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.31451884
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31162684
123Glutathione metabolism_Homo sapiens_hsa004800.31122966
124Salivary secretion_Homo sapiens_hsa049700.28961444
125Dopaminergic synapse_Homo sapiens_hsa047280.27360537
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26940014
127Vibrio cholerae infection_Homo sapiens_hsa051100.26066454
128ABC transporters_Homo sapiens_hsa020100.24697838
129Morphine addiction_Homo sapiens_hsa050320.23871892
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23475000
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.22727967
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.21403288
133Folate biosynthesis_Homo sapiens_hsa007900.21230144

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