SUCLA2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.23348953
2proteasome assembly (GO:0043248)5.14610636
3DNA double-strand break processing (GO:0000729)4.86265341
4protein deneddylation (GO:0000338)4.76615674
5cullin deneddylation (GO:0010388)4.63753278
6protein neddylation (GO:0045116)4.55567666
7respiratory chain complex IV assembly (GO:0008535)4.40824206
8maturation of 5.8S rRNA (GO:0000460)4.32425105
9protein complex biogenesis (GO:0070271)4.23330377
10nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.09908144
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.04818048
12mitochondrial respiratory chain complex assembly (GO:0033108)4.02168429
13cytochrome complex assembly (GO:0017004)4.01553744
14DNA catabolic process, exonucleolytic (GO:0000738)3.69865177
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69766103
16DNA ligation (GO:0006266)3.60679154
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.60521835
18NADH dehydrogenase complex assembly (GO:0010257)3.60521835
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60521835
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.55990863
21succinate metabolic process (GO:0006105)3.55074520
22regulation of cellular amino acid metabolic process (GO:0006521)3.54484749
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51401263
24histone H2A acetylation (GO:0043968)3.48949371
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48507200
26cellular ketone body metabolic process (GO:0046950)3.48072786
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45229732
28regulation of mitochondrial translation (GO:0070129)3.42175083
29chaperone-mediated protein transport (GO:0072321)3.38009789
30platelet dense granule organization (GO:0060155)3.37340953
31regulation of mitotic spindle checkpoint (GO:1903504)3.36663143
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36663143
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31087600
34negative regulation of ligase activity (GO:0051352)3.31087600
35cytidine deamination (GO:0009972)3.29309437
36cytidine metabolic process (GO:0046087)3.29309437
37cytidine catabolic process (GO:0006216)3.29309437
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23059846
39DNA damage response, detection of DNA damage (GO:0042769)3.22877667
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20523911
41ketone body metabolic process (GO:1902224)3.19714326
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18153836
43water-soluble vitamin biosynthetic process (GO:0042364)3.17989031
44rRNA modification (GO:0000154)3.16702826
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15695654
46mannosylation (GO:0097502)3.15110417
47ATP synthesis coupled proton transport (GO:0015986)3.13205102
48energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13205102
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.13020275
50branched-chain amino acid catabolic process (GO:0009083)3.11182648
51protein-cofactor linkage (GO:0018065)3.09837483
52peptidyl-cysteine modification (GO:0018198)3.09478373
53signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08603437
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08603437
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08603437
56L-methionine salvage (GO:0071267)3.07051181
57L-methionine biosynthetic process (GO:0071265)3.07051181
58amino acid salvage (GO:0043102)3.07051181
59tricarboxylic acid cycle (GO:0006099)3.06139334
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05548807
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05548807
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05505601
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05505601
64somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.05286882
65isotype switching (GO:0045190)3.05286882
66somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.05286882
67iron-sulfur cluster assembly (GO:0016226)3.05137226
68metallo-sulfur cluster assembly (GO:0031163)3.05137226
69respiratory electron transport chain (GO:0022904)3.04614568
70negative regulation of DNA recombination (GO:0045910)3.01428036
71electron transport chain (GO:0022900)2.99553154
72negative regulation of membrane potential (GO:0045837)2.99173482
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99130663
74ubiquinone biosynthetic process (GO:0006744)2.98858245
75histone mRNA metabolic process (GO:0008334)2.94057448
76signal transduction involved in cell cycle checkpoint (GO:0072395)2.93608826
77amino acid activation (GO:0043038)2.92392699
78tRNA aminoacylation (GO:0043039)2.92392699
79signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91011270
80signal transduction involved in DNA damage checkpoint (GO:0072422)2.91011270
81ribonucleoprotein complex disassembly (GO:0032988)2.89549131
82positive regulation of ligase activity (GO:0051351)2.89147891
83tRNA aminoacylation for protein translation (GO:0006418)2.87814985
84ubiquinone metabolic process (GO:0006743)2.82412077
85ribosome assembly (GO:0042255)2.81927091
86protein refolding (GO:0042026)2.81379052
87rRNA methylation (GO:0031167)2.79864168
88tRNA metabolic process (GO:0006399)2.78558743
89pyrimidine ribonucleoside catabolic process (GO:0046133)2.77701169
90spliceosomal snRNP assembly (GO:0000387)2.77387147
91organelle disassembly (GO:1903008)2.77196051
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.76149861
93termination of RNA polymerase III transcription (GO:0006386)2.76149861
94regulation of helicase activity (GO:0051095)2.75254963
95establishment of integrated proviral latency (GO:0075713)2.72720366
96tRNA processing (GO:0008033)2.72444535
97preassembly of GPI anchor in ER membrane (GO:0016254)2.72404467
98inner mitochondrial membrane organization (GO:0007007)2.72363870
99replication fork processing (GO:0031297)2.72211298
100positive regulation of mitochondrial fission (GO:0090141)2.71888824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.65239670
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42963233
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.13080669
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.29666808
5ZNF274_21170338_ChIP-Seq_K562_Hela3.03748075
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92893722
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.88971535
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81367793
9VDR_23849224_ChIP-Seq_CD4+_Human2.62278545
10ELK1_19687146_ChIP-ChIP_HELA_Human2.54264554
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42950550
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42817818
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.40825434
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.36691886
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.33092023
16VDR_22108803_ChIP-Seq_LS180_Human2.33008580
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28823391
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23274463
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17531381
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12245019
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02308754
22FOXP3_21729870_ChIP-Seq_TREG_Human2.01395426
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97807018
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95736549
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91958626
26IGF1R_20145208_ChIP-Seq_DFB_Human1.87223256
27EWS_26573619_Chip-Seq_HEK293_Human1.84055789
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.77562603
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76105875
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74865622
31FUS_26573619_Chip-Seq_HEK293_Human1.69266025
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69053580
33P300_19829295_ChIP-Seq_ESCs_Human1.68544172
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68538715
35GBX2_23144817_ChIP-Seq_PC3_Human1.65657363
36MYC_18940864_ChIP-ChIP_HL60_Human1.65086109
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52000312
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51102090
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.46039891
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45131017
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44453707
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39873912
43GABP_19822575_ChIP-Seq_HepG2_Human1.39823443
44TAF15_26573619_Chip-Seq_HEK293_Human1.39246554
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38316158
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.38107526
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30487414
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.29276816
49DCP1A_22483619_ChIP-Seq_HELA_Human1.28547881
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28041140
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27118156
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.24200344
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23289309
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.20971015
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20862188
56TP53_22573176_ChIP-Seq_HFKS_Human1.20707104
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19595078
58TTF2_22483619_ChIP-Seq_HELA_Human1.18432308
59E2F7_22180533_ChIP-Seq_HELA_Human1.16817788
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15995616
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15065775
62SOX2_19829295_ChIP-Seq_ESCs_Human1.14836959
63NANOG_19829295_ChIP-Seq_ESCs_Human1.14836959
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14085009
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12929032
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12715251
67CBP_20019798_ChIP-Seq_JUKART_Human1.12607740
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12607740
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12392252
70ER_23166858_ChIP-Seq_MCF-7_Human1.11483428
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11007841
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.09593266
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08948035
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08890196
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08763940
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.08763940
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.08093118
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06400296
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05185226
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.04478412
81HTT_18923047_ChIP-ChIP_STHdh_Human1.04368695
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03716751
83TCF4_22108803_ChIP-Seq_LS180_Human0.98523085
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98226974
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95666935
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.94922096
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94810001
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93995333
89THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93605607
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.93418228
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93286854
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.89850314
93IRF1_19129219_ChIP-ChIP_H3396_Human0.89711255
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89501962
95CDX2_22108803_ChIP-Seq_LS180_Human0.88746456
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88712505
97MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88575153
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86744997
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86741053
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86450418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.16106865
2MP0002822_catalepsy3.09666467
3MP0006072_abnormal_retinal_apoptosis3.01713478
4MP0008058_abnormal_DNA_repair2.99608297
5MP0003693_abnormal_embryo_hatching2.57176015
6MP0003880_abnormal_central_pattern2.50575419
7MP0001529_abnormal_vocalization2.50035122
8MP0002102_abnormal_ear_morphology2.48904952
9MP0004147_increased_porphyrin_level2.41569283
10MP0002837_dystrophic_cardiac_calcinosis2.40430916
11MP0010094_abnormal_chromosome_stability2.35949423
12MP0006035_abnormal_mitochondrial_morpho2.23292502
13MP0003195_calcinosis2.14603496
14MP0006036_abnormal_mitochondrial_physio2.13126571
15MP0002638_abnormal_pupillary_reflex2.06530409
16MP0005551_abnormal_eye_electrophysiolog1.96212795
17MP0006276_abnormal_autonomic_nervous1.92840825
18MP0005253_abnormal_eye_physiology1.92601188
19MP0003786_premature_aging1.88592996
20MP0001984_abnormal_olfaction1.87544254
21MP0003806_abnormal_nucleotide_metabolis1.85160703
22MP0004957_abnormal_blastocyst_morpholog1.76444866
23MP0004215_abnormal_myocardial_fiber1.73294549
24MP0005075_abnormal_melanosome_morpholog1.72755727
25MP0003718_maternal_effect1.62829893
26MP0003011_delayed_dark_adaptation1.59779339
27MP0001188_hyperpigmentation1.58116320
28MP0001485_abnormal_pinna_reflex1.56881755
29MP0009046_muscle_twitch1.55062882
30MP0006054_spinal_hemorrhage1.53813004
31MP0000372_irregular_coat_pigmentation1.49372644
32MP0003787_abnormal_imprinting1.46190081
33MP0001293_anophthalmia1.45337778
34MP0002751_abnormal_autonomic_nervous1.44721930
35MP0000427_abnormal_hair_cycle1.44669956
36MP0005645_abnormal_hypothalamus_physiol1.43218274
37MP0001486_abnormal_startle_reflex1.37341013
38MP0005367_renal/urinary_system_phenotyp1.33887663
39MP0000516_abnormal_urinary_system1.33887663
40MP0005084_abnormal_gallbladder_morpholo1.31395917
41MP0002163_abnormal_gland_morphology1.30782347
42MP0008932_abnormal_embryonic_tissue1.28854110
43MP0008789_abnormal_olfactory_epithelium1.28539112
44MP0002095_abnormal_skin_pigmentation1.26475938
45MP0002736_abnormal_nociception_after1.25610997
46MP0003186_abnormal_redox_activity1.24857993
47MP0008995_early_reproductive_senescence1.24161544
48MP0001764_abnormal_homeostasis1.22807569
49MP0004145_abnormal_muscle_electrophysio1.21173711
50MP0000358_abnormal_cell_content/1.20704693
51MP0002735_abnormal_chemical_nociception1.20168164
52MP0009745_abnormal_behavioral_response1.18051736
53MP0001905_abnormal_dopamine_level1.13560587
54MP0005394_taste/olfaction_phenotype1.13455957
55MP0005499_abnormal_olfactory_system1.13455957
56MP0008775_abnormal_heart_ventricle1.13304037
57MP0003111_abnormal_nucleus_morphology1.12202584
58MP0002876_abnormal_thyroid_physiology1.11877868
59MP0001324_abnormal_eye_pigmentation1.09883354
60MP0008007_abnormal_cellular_replicative1.08779357
61MP0000749_muscle_degeneration1.07791150
62MP0002272_abnormal_nervous_system1.05479970
63MP0008875_abnormal_xenobiotic_pharmacok1.05355931
64MP0002909_abnormal_adrenal_gland1.01951120
65MP0002160_abnormal_reproductive_system1.00579121
66MP0000647_abnormal_sebaceous_gland1.00236721
67MP0001929_abnormal_gametogenesis0.99107217
68MP0005671_abnormal_response_to0.98207612
69MP0003121_genomic_imprinting0.97368077
70MP0005379_endocrine/exocrine_gland_phen0.97109636
71MP0001501_abnormal_sleep_pattern0.96865161
72MP0003878_abnormal_ear_physiology0.95464724
73MP0005377_hearing/vestibular/ear_phenot0.95464724
74MP0003122_maternal_imprinting0.93356292
75MP0000569_abnormal_digit_pigmentation0.92627597
76MP0006292_abnormal_olfactory_placode0.92361330
77MP0003890_abnormal_embryonic-extraembry0.92000980
78MP0002090_abnormal_vision0.91087246
79MP0003937_abnormal_limbs/digits/tail_de0.90070920
80MP0005389_reproductive_system_phenotype0.89005890
81MP0008057_abnormal_DNA_replication0.88546095
82MP0001968_abnormal_touch/_nociception0.88091198
83MP0005646_abnormal_pituitary_gland0.86319023
84MP0004885_abnormal_endolymph0.85510286
85MP0000015_abnormal_ear_pigmentation0.84649033
86MP0002277_abnormal_respiratory_mucosa0.84564461
87MP0009765_abnormal_xenobiotic_induced0.83248945
88MP0005332_abnormal_amino_acid0.82265057
89MP0004142_abnormal_muscle_tone0.82103197
90MP0002210_abnormal_sex_determination0.82071486
91MP0003567_abnormal_fetal_cardiomyocyte0.81952615
92MP0003137_abnormal_impulse_conducting0.81175243
93MP0003077_abnormal_cell_cycle0.80686575
94MP0003119_abnormal_digestive_system0.79920753
95MP0001986_abnormal_taste_sensitivity0.78721688
96MP0002752_abnormal_somatic_nervous0.77471736
97MP0000653_abnormal_sex_gland0.76981637
98MP0009785_altered_susceptibility_to0.74871529
99MP0000049_abnormal_middle_ear0.73765842
100MP0005195_abnormal_posterior_eye0.73596174

Predicted human phenotypes

RankGene SetZ-score
1Abnormal activity of mitochondrial respiratory chain (HP:0011922)5.05946468
2Decreased activity of mitochondrial respiratory chain (HP:0008972)5.05946468
3Methylmalonic acidemia (HP:0002912)4.67661674
4Methylmalonic aciduria (HP:0012120)3.99909985
5Acute necrotizing encephalopathy (HP:0006965)3.58553567
6Progressive inability to walk (HP:0002505)3.50006161
7Hepatic necrosis (HP:0002605)3.47349716
8Increased CSF lactate (HP:0002490)3.46197274
9Generalized aminoaciduria (HP:0002909)3.37172402
10Mitochondrial inheritance (HP:0001427)3.30724197
113-Methylglutaconic aciduria (HP:0003535)3.28496130
12Facial diplegia (HP:0001349)3.27736153
13Hepatocellular necrosis (HP:0001404)3.24348407
14Abnormal mitochondria in muscle tissue (HP:0008316)3.22650181
15Acute encephalopathy (HP:0006846)3.21771209
16Pancreatic cysts (HP:0001737)3.12094910
17Progressive macrocephaly (HP:0004481)3.08248982
18Abnormality of the labia minora (HP:0012880)2.98622573
19Abnormality of vitamin B metabolism (HP:0004340)2.98226571
20Increased serum lactate (HP:0002151)2.97613466
21Renal cortical cysts (HP:0000803)2.95068231
22Abnormality of the vitamin B12 metabolism (HP:0004341)2.93619428
23Increased hepatocellular lipid droplets (HP:0006565)2.82866667
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.72526276
25Abnormality of alanine metabolism (HP:0010916)2.72526276
26Hyperalaninemia (HP:0003348)2.72526276
27Lactic acidosis (HP:0003128)2.68922817
28Cerebral edema (HP:0002181)2.64445027
29Increased intramyocellular lipid droplets (HP:0012240)2.60909570
30True hermaphroditism (HP:0010459)2.60769361
31Type I transferrin isoform profile (HP:0003642)2.60320760
32Nephronophthisis (HP:0000090)2.53889129
33Lipid accumulation in hepatocytes (HP:0006561)2.53181703
34Medial flaring of the eyebrow (HP:0010747)2.50403075
35Hypothermia (HP:0002045)2.48899270
36Pancreatic fibrosis (HP:0100732)2.45719717
37Bile duct proliferation (HP:0001408)2.44643163
38Abnormal biliary tract physiology (HP:0012439)2.44643163
39Hypoglycemic coma (HP:0001325)2.42892536
40Increased serum pyruvate (HP:0003542)2.41536343
41Delayed gross motor development (HP:0002194)2.38117461
42Dicarboxylic aciduria (HP:0003215)2.37729644
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37729644
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35759582
45Abnormality of the renal cortex (HP:0011035)2.35133610
46Abnormality of glycolysis (HP:0004366)2.25790387
47Inability to walk (HP:0002540)2.24412847
48Keratoconus (HP:0000563)2.21353077
49Increased corneal curvature (HP:0100692)2.21353077
50Gaze-evoked nystagmus (HP:0000640)2.20982168
51Abnormality of midbrain morphology (HP:0002418)2.18562842
52Molar tooth sign on MRI (HP:0002419)2.18562842
53Glycosuria (HP:0003076)2.18550820
54Abnormality of urine glucose concentration (HP:0011016)2.18550820
55Palpitations (HP:0001962)2.12632345
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12240259
57Abnormal protein N-linked glycosylation (HP:0012347)2.12240259
58Abnormal protein glycosylation (HP:0012346)2.12240259
59Abnormal glycosylation (HP:0012345)2.12240259
60Colon cancer (HP:0003003)2.11907965
61Pendular nystagmus (HP:0012043)2.10843884
62Congenital stationary night blindness (HP:0007642)2.09892082
63Aplasia/hypoplasia of the uterus (HP:0008684)2.09696733
64Tongue fasciculations (HP:0001308)2.09600738
65Proximal tubulopathy (HP:0000114)2.08023738
66Optic disc pallor (HP:0000543)2.05311057
67Posterior subcapsular cataract (HP:0007787)2.03971758
68Abnormality of the ileum (HP:0001549)2.03303977
69Meckel diverticulum (HP:0002245)2.03196656
70Exercise intolerance (HP:0003546)2.02573353
71Poor suck (HP:0002033)2.01100787
72Carpal bone hypoplasia (HP:0001498)2.00205155
73Abnormality of the renal medulla (HP:0100957)1.99919000
74Gonadotropin excess (HP:0000837)1.99829508
75Increased muscle lipid content (HP:0009058)1.98708947
76Abnormality of vitamin metabolism (HP:0100508)1.97540485
77Nausea (HP:0002018)1.95220549
78Exertional dyspnea (HP:0002875)1.93521723
79Abnormality of the anterior horn cell (HP:0006802)1.93236590
80Degeneration of anterior horn cells (HP:0002398)1.93236590
81Renal Fanconi syndrome (HP:0001994)1.89566782
82Respiratory failure (HP:0002878)1.87457915
83Abolished electroretinogram (ERG) (HP:0000550)1.85811870
84Type 2 muscle fiber atrophy (HP:0003554)1.84948628
85Abnormality of serum amino acid levels (HP:0003112)1.84039222
86Congenital primary aphakia (HP:0007707)1.82291363
87Nephrogenic diabetes insipidus (HP:0009806)1.80498632
88Lethargy (HP:0001254)1.78254185
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76688860
90Increased IgM level (HP:0003496)1.75772276
91Ketoacidosis (HP:0001993)1.74066734
92Gait imbalance (HP:0002141)1.73901326
93Abnormality of methionine metabolism (HP:0010901)1.71653580
94IgG deficiency (HP:0004315)1.70679468
95Delayed CNS myelination (HP:0002188)1.70441994
96Cutaneous melanoma (HP:0012056)1.68208201
97Sclerocornea (HP:0000647)1.67845597
98Neoplasm of the adrenal gland (HP:0100631)1.66389354
99Hyperglycinemia (HP:0002154)1.64702160
100Hypoproteinemia (HP:0003075)1.64464369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.76704842
2BCR3.17785078
3MAP4K22.95641781
4TSSK62.94447444
5WNK32.64038513
6NEK12.63330078
7SRPK12.63116894
8EIF2AK32.52140150
9PINK12.42607351
10NUAK12.35068448
11MKNK22.31332412
12MST42.30166513
13BCKDK2.26099202
14BUB12.17191200
15EIF2AK12.04883460
16ZAK1.83793212
17MKNK11.81715303
18TLK11.78435592
19INSRR1.78086001
20ACVR1B1.77726561
21TXK1.76258373
22FRK1.70201288
23CSNK1G31.68891230
24PLK31.63718457
25GRK11.62051780
26CSNK1G11.54267887
27ADRBK21.50411326
28CSNK1G21.45789541
29ERBB31.35942080
30OXSR11.28708763
31MAP3K121.27318211
32CSNK1A1L1.26338973
33CDK191.24755917
34PLK41.21798574
35DAPK21.20074881
36BMPR1B1.18348214
37MAP2K61.09741622
38VRK21.09440195
39PLK21.06035450
40PDK21.05224778
41MAPK131.04996094
42SIK31.04794270
43TTK1.02971137
44WNK41.01657124
45CDC71.00372674
46TAF10.95579759
47MAPKAPK50.94163848
48PLK10.93383437
49NEK20.87665559
50BRSK20.83568585
51TNIK0.80099878
52STK390.79207061
53STK160.78947216
54WEE10.78115523
55PHKG10.77666788
56PHKG20.77666788
57CAMKK20.74798176
58PBK0.74202726
59VRK10.74010232
60PRKCG0.73934592
61SIK20.73877063
62KDR0.69282245
63PAK30.65464559
64EIF2AK20.65197013
65DYRK20.63925819
66LIMK10.60277012
67STK240.59498682
68NME10.58546376
69ALK0.57801890
70PRKCE0.54438503
71ATR0.53523860
72AURKB0.50595857
73BRSK10.48551394
74CSNK1A10.47128428
75MUSK0.44950656
76PNCK0.44524214
77MINK10.43925414
78CSNK2A10.42391120
79CCNB10.41723286
80MAP2K70.41309019
81TIE10.41083198
82OBSCN0.40158524
83GRK70.39586462
84ATM0.39445663
85MAP3K40.39306675
86FER0.38055456
87TGFBR10.38005841
88CDK30.37363903
89ILK0.37343951
90CAMK2A0.36144059
91DAPK10.36055298
92BMPR20.35107973
93RPS6KA50.34589402
94PRKCQ0.32427686
95IGF1R0.31937066
96EGFR0.31184227
97CSNK1D0.29948328
98PRKCI0.29807757
99ADRBK10.27503462
100CSNK2A20.27489903

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.19097541
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.36368225
3Protein export_Homo sapiens_hsa030603.34283649
4Oxidative phosphorylation_Homo sapiens_hsa001902.90036348
5Propanoate metabolism_Homo sapiens_hsa006402.84285331
6Parkinsons disease_Homo sapiens_hsa050122.50386807
7Non-homologous end-joining_Homo sapiens_hsa034502.27034988
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.22436440
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11230365
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07496222
11RNA polymerase_Homo sapiens_hsa030202.06986832
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06523335
13Basal transcription factors_Homo sapiens_hsa030222.03336045
14Mismatch repair_Homo sapiens_hsa034301.86230191
15Homologous recombination_Homo sapiens_hsa034401.86030750
16Butanoate metabolism_Homo sapiens_hsa006501.84770192
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80264842
18Sulfur metabolism_Homo sapiens_hsa009201.79577401
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76878156
20RNA degradation_Homo sapiens_hsa030181.75949531
21Phototransduction_Homo sapiens_hsa047441.73618653
22Huntingtons disease_Homo sapiens_hsa050161.61419056
23Fatty acid elongation_Homo sapiens_hsa000621.54752302
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54573390
25RNA transport_Homo sapiens_hsa030131.52100015
26Alzheimers disease_Homo sapiens_hsa050101.48294766
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44642435
28DNA replication_Homo sapiens_hsa030301.38403891
29Fanconi anemia pathway_Homo sapiens_hsa034601.37447437
30Nucleotide excision repair_Homo sapiens_hsa034201.35585661
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28195384
32Steroid biosynthesis_Homo sapiens_hsa001001.25329193
33Spliceosome_Homo sapiens_hsa030401.22431768
34One carbon pool by folate_Homo sapiens_hsa006701.21077090
35Peroxisome_Homo sapiens_hsa041461.17834405
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17574193
37Purine metabolism_Homo sapiens_hsa002301.17085075
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.15341477
39Base excision repair_Homo sapiens_hsa034101.13614376
40Pyrimidine metabolism_Homo sapiens_hsa002401.12785573
41Antigen processing and presentation_Homo sapiens_hsa046121.09249779
42Pyruvate metabolism_Homo sapiens_hsa006201.05364755
43Graft-versus-host disease_Homo sapiens_hsa053321.04703594
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04244636
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99772243
46Regulation of autophagy_Homo sapiens_hsa041400.99680733
47Nitrogen metabolism_Homo sapiens_hsa009100.98806365
48Selenocompound metabolism_Homo sapiens_hsa004500.98461049
49Caffeine metabolism_Homo sapiens_hsa002320.90796208
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90061179
51Collecting duct acid secretion_Homo sapiens_hsa049660.89480292
52Type I diabetes mellitus_Homo sapiens_hsa049400.84083288
53Cardiac muscle contraction_Homo sapiens_hsa042600.83726479
54Circadian rhythm_Homo sapiens_hsa047100.83652937
55Carbon metabolism_Homo sapiens_hsa012000.79894937
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79094280
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74705399
58Nicotine addiction_Homo sapiens_hsa050330.74101676
59Metabolic pathways_Homo sapiens_hsa011000.72315020
60Linoleic acid metabolism_Homo sapiens_hsa005910.71484700
61Oocyte meiosis_Homo sapiens_hsa041140.68996952
62Ether lipid metabolism_Homo sapiens_hsa005650.65776134
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63907641
64Retinol metabolism_Homo sapiens_hsa008300.63728733
65Fatty acid metabolism_Homo sapiens_hsa012120.61025352
66Tryptophan metabolism_Homo sapiens_hsa003800.59079852
67Rheumatoid arthritis_Homo sapiens_hsa053230.56986535
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56044070
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54368694
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54034254
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50759507
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.50292105
73Chemical carcinogenesis_Homo sapiens_hsa052040.50225556
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50211412
75Fatty acid degradation_Homo sapiens_hsa000710.50122634
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48291056
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.48282955
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47287520
79Autoimmune thyroid disease_Homo sapiens_hsa053200.46845953
80Taste transduction_Homo sapiens_hsa047420.46773872
81Arginine and proline metabolism_Homo sapiens_hsa003300.46172090
82Folate biosynthesis_Homo sapiens_hsa007900.45984583
83Cell cycle_Homo sapiens_hsa041100.45936663
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45719198
85p53 signaling pathway_Homo sapiens_hsa041150.45463786
86GABAergic synapse_Homo sapiens_hsa047270.44422739
87Glutathione metabolism_Homo sapiens_hsa004800.44283857
88Allograft rejection_Homo sapiens_hsa053300.42095713
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41644137
90N-Glycan biosynthesis_Homo sapiens_hsa005100.39411110
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37960018
92beta-Alanine metabolism_Homo sapiens_hsa004100.37280957
93mRNA surveillance pathway_Homo sapiens_hsa030150.37043578
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36511656
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34696644
96Asthma_Homo sapiens_hsa053100.29176069
97Legionellosis_Homo sapiens_hsa051340.28851025
98Ribosome_Homo sapiens_hsa030100.28142893
99Biosynthesis of amino acids_Homo sapiens_hsa012300.28026259
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28024976

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »