ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule catabolic process (GO:0016998)	5.48284025
2	positive regulation of mitochondrial fission (GO:0090141)	4.98954989
3	neural tube formation (GO:0001841)	4.91388381
4	limb bud formation (GO:0060174)	4.73828510
5	cell wall macromolecule metabolic process (GO:0044036)	4.50824045
6	cornea development in camera-type eye (GO:0061303)	4.15065785
7	regulation of timing of cell differentiation (GO:0048505)	4.09229912
8	replication fork processing (GO:0031297)	4.04160568
9	striated muscle atrophy (GO:0014891)	3.85660020
10	monoubiquitinated protein deubiquitination (GO:0035520)	3.77925927
11	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.76407366
12	skeletal muscle adaptation (GO:0043501)	3.75304845
13	negative regulation of mast cell activation (GO:0033004)	3.61024592
14	somite development (GO:0061053)	3.54295707
15	negative chemotaxis (GO:0050919)	3.53097365
16	regulation of development, heterochronic (GO:0040034)	3.51869084
17	dorsal/ventral axis specification (GO:0009950)	3.47916198
18	presynaptic membrane assembly (GO:0097105)	3.38161095
19	muscle atrophy (GO:0014889)	3.38037565
20	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.37725570
21	regulation of mitochondrial fission (GO:0090140)	3.37505994
22	auditory receptor cell differentiation (GO:0042491)	3.33512889
23	protein polyglutamylation (GO:0018095)	3.25650413
24	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.23333572
25	intraciliary transport (GO:0042073)	3.19915092
26	sympathetic nervous system development (GO:0048485)	3.17524122
27	resolution of meiotic recombination intermediates (GO:0000712)	3.17314218
28	peroxisome fission (GO:0016559)	3.11672252
29	detection of light stimulus involved in sensory perception (GO:0050962)	3.09443684
30	detection of light stimulus involved in visual perception (GO:0050908)	3.09443684
31	histone H2A acetylation (GO:0043968)	3.09118894
32	regulation of DNA endoreduplication (GO:0032875)	3.05129129
33	central nervous system projection neuron axonogenesis (GO:0021952)	3.00363150
34	DNA double-strand break processing (GO:0000729)	2.99834258
35	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.98921421
36	presynaptic membrane organization (GO:0097090)	2.96947753
37	interkinetic nuclear migration (GO:0022027)	2.96819397
38	epithelial cilium movement (GO:0003351)	2.94586067
39	serine family amino acid catabolic process (GO:0009071)	2.93138672
40	multicellular organism reproduction (GO:0032504)	2.91971118
41	acrosome reaction (GO:0007340)	2.91436506
42	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.90422117
43	epithelial cell fate commitment (GO:0072148)	2.90274007
44	axoneme assembly (GO:0035082)	2.90155036
45	neuronal action potential (GO:0019228)	2.89305862
46	anterograde synaptic vesicle transport (GO:0048490)	2.88749896
47	central nervous system neuron axonogenesis (GO:0021955)	2.88468353
48	glial cell proliferation (GO:0014009)	2.85450157
49	otic vesicle formation (GO:0030916)	2.84037910
50	righting reflex (GO:0060013)	2.84010543
51	response to gravity (GO:0009629)	2.83228681
52	photoreceptor cell maintenance (GO:0045494)	2.82998135
53	retinal ganglion cell axon guidance (GO:0031290)	2.80261794
54	kynurenine metabolic process (GO:0070189)	2.78438798
55	DNA integration (GO:0015074)	2.78292535
56	heart field specification (GO:0003128)	2.77569418
57	secondary heart field specification (GO:0003139)	2.77569418
58	regulation of axon guidance (GO:1902667)	2.73585643
59	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.72314975
60	proline transport (GO:0015824)	2.71940451
61	postreplication repair (GO:0006301)	2.68897138
62	DNA demethylation (GO:0080111)	2.64973607
63	cilium morphogenesis (GO:0060271)	2.64371292
64	sialylation (GO:0097503)	2.62797066
65	outer ear morphogenesis (GO:0042473)	2.62746056
66	mitochondrial fission (GO:0000266)	2.62052062
67	tachykinin receptor signaling pathway (GO:0007217)	2.61613697
68	cardiac left ventricle morphogenesis (GO:0003214)	2.60554540
69	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.58819135
70	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.57882000
71	adaptation of signaling pathway (GO:0023058)	2.56184182
72	regulation of dendritic spine development (GO:0060998)	2.55722405
73	tryptophan catabolic process (GO:0006569)	2.55553419
74	indole-containing compound catabolic process (GO:0042436)	2.55553419
75	indolalkylamine catabolic process (GO:0046218)	2.55553419
76	embryonic epithelial tube formation (GO:0001838)	2.54630803
77	appendage development (GO:0048736)	2.53227821
78	limb development (GO:0060173)	2.53227821
79	translesion synthesis (GO:0019985)	2.52985442
80	cilium assembly (GO:0042384)	2.52608207
81	cilium organization (GO:0044782)	2.51223343
82	indolalkylamine metabolic process (GO:0006586)	2.50411820
83	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.47935552
84	regulation of dendritic spine morphogenesis (GO:0061001)	2.47556062
85	behavioral response to nicotine (GO:0035095)	2.46308525
86	negative regulation of axon guidance (GO:1902668)	2.45702622
87	morphogenesis of an endothelium (GO:0003159)	2.45441848
88	endothelial tube morphogenesis (GO:0061154)	2.45441848
89	DNA replication-dependent nucleosome assembly (GO:0006335)	2.43711413
90	DNA replication-dependent nucleosome organization (GO:0034723)	2.43711413
91	olfactory bulb development (GO:0021772)	2.43644219
92	cilium movement (GO:0003341)	2.42871003
93	positive regulation of cell fate commitment (GO:0010455)	2.42585855
94	reflex (GO:0060004)	2.42548505
95	epithelial tube formation (GO:0072175)	2.41368435
96	regulation of axon extension involved in axon guidance (GO:0048841)	2.40694794
97	negative regulation of cell aging (GO:0090344)	2.40625346
98	cellular ketone body metabolic process (GO:0046950)	2.40260897
99	pituitary gland development (GO:0021983)	2.40238302
100	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.39810496

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.36070035
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.70957477
3	VDR_22108803_ChIP-Seq_LS180_Human	3.56689708
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.29963829
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.23221673
6	TAF15_26573619_Chip-Seq_HEK293_Human	3.19675179
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.03713863
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.84566034
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.80898409
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.68788939
11	FUS_26573619_Chip-Seq_HEK293_Human	2.53134330
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.51837619
13	P300_19829295_ChIP-Seq_ESCs_Human	2.49463815
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26559597
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.20398383
16	EWS_26573619_Chip-Seq_HEK293_Human	2.19009108
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05866271
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.98476579
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.97470926
20	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.95652355
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.89936021
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87293641
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.84942542
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.82305870
25	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.82001268
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.78039680
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75514165
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.74707720
29	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.67587628
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64459280
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62939373
32	STAT3_23295773_ChIP-Seq_U87_Human	1.61833096
33	AR_21572438_ChIP-Seq_LNCaP_Human	1.59452414
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56930586
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56771297
36	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.55528253
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53201757
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53201757
39	TCF4_23295773_ChIP-Seq_U87_Human	1.51749904
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50346702
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49310562
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.48227817
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.48227817
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48190770
45	AR_25329375_ChIP-Seq_VCAP_Human	1.47285556
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44347941
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39209773
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38777748
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.37967402
50	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.34952244
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34486536
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.32193599
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32193599
54	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.31532318
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.31360849
56	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.31206125
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29187575
58	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.28599335
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.25017374
60	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24183733
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.22915162
62	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.20826630
63	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20277655
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19582046
65	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18386768
66	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.18289613
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17544163
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15939693
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15704974
70	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.14954491
71	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.14114918
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12658169
73	JUN_21703547_ChIP-Seq_K562_Human	1.12196333
74	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.10957583
75	ELK1_19687146_ChIP-ChIP_HELA_Human	1.10938990
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10043832
77	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.08833506
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07677983
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.07626322
80	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.07125981
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06963930
82	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.06157076
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06127290
84	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04915700
85	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04513938
86	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.03441603
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01430833
88	TP53_22573176_ChIP-Seq_HFKS_Human	1.01327170
89	SOX9_26525672_Chip-Seq_HEART_Mouse	1.01311982
90	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01183016
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01177206
92	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.00850816
93	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.00265592
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.99875605
95	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99703278
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99210556
97	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99122678
98	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98845288
99	KDM2B_26808549_Chip-Seq_REH_Human	0.98617177
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.98349304

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.52619208
2	MP0003880_abnormal_central_pattern	4.36003659
3	MP0002837_dystrophic_cardiac_calcinosis	3.81010378
4	MP0003787_abnormal_imprinting	3.12358948
5	MP0006072_abnormal_retinal_apoptosis	2.72965891
6	MP0006054_spinal_hemorrhage	2.60303761
7	MP0005551_abnormal_eye_electrophysiolog	2.30060349
8	MP0005423_abnormal_somatic_nervous	2.27912952
9	MP0003890_abnormal_embryonic-extraembry	2.22121718
10	MP0008877_abnormal_DNA_methylation	2.19900326
11	MP0002938_white_spotting	2.15592811
12	MP0003567_abnormal_fetal_cardiomyocyte	2.08371933
13	MP0001529_abnormal_vocalization	2.04391623
14	MP0003121_genomic_imprinting	2.03129534
15	MP0001986_abnormal_taste_sensitivity	1.85912156
16	MP0000372_irregular_coat_pigmentation	1.81599865
17	MP0005253_abnormal_eye_physiology	1.80066046
18	MP0004885_abnormal_endolymph	1.75928613
19	MP0005174_abnormal_tail_pigmentation	1.75133632
20	MP0001485_abnormal_pinna_reflex	1.74477733
21	MP0001486_abnormal_startle_reflex	1.69351369
22	MP0000778_abnormal_nervous_system	1.66205531
23	MP0003937_abnormal_limbs/digits/tail_de	1.64106283
24	MP0004270_analgesia	1.52288857
25	MP0002735_abnormal_chemical_nociception	1.47627549
26	MP0004133_heterotaxia	1.46959235
27	MP0004084_abnormal_cardiac_muscle	1.45447007
28	MP0003718_maternal_effect	1.43224678
29	MP0003941_abnormal_skin_development	1.42750655
30	MP0006292_abnormal_olfactory_placode	1.39834925
31	MP0009046_muscle_twitch	1.38901180
32	MP0005386_behavior/neurological_phenoty	1.38377914
33	MP0004924_abnormal_behavior	1.38377914
34	MP0005248_abnormal_Harderian_gland	1.37821005
35	MP0001346_abnormal_lacrimal_gland	1.37258967
36	MP0002095_abnormal_skin_pigmentation	1.37044408
37	MP0002751_abnormal_autonomic_nervous	1.31952770
38	MP0001968_abnormal_touch/_nociception	1.31803907
39	MP0004215_abnormal_myocardial_fiber	1.31464419
40	MP0002168_other_aberrant_phenotype	1.31038951
41	MP0002736_abnormal_nociception_after	1.30639670
42	MP0002090_abnormal_vision	1.30582014
43	MP0004145_abnormal_muscle_electrophysio	1.30315623
44	MP0000049_abnormal_middle_ear	1.29416257
45	MP0000631_abnormal_neuroendocrine_gland	1.29394534
46	MP0003943_abnormal_hepatobiliary_system	1.28801064
47	MP0005395_other_phenotype	1.27329297
48	MP0009745_abnormal_behavioral_response	1.27151212
49	MP0004147_increased_porphyrin_level	1.25493799
50	MP0006276_abnormal_autonomic_nervous	1.21555956
51	MP0000647_abnormal_sebaceous_gland	1.21149209
52	MP0004036_abnormal_muscle_relaxation	1.20146834
53	MP0003755_abnormal_palate_morphology	1.15812495
54	MP0009780_abnormal_chondrocyte_physiolo	1.15511676
55	MP0008775_abnormal_heart_ventricle	1.15087018
56	MP0003136_yellow_coat_color	1.12295984
57	MP0000371_diluted_coat_color	1.09789709
58	MP0006035_abnormal_mitochondrial_morpho	1.07005965
59	MP0002272_abnormal_nervous_system	1.06884735
60	MP0001293_anophthalmia	1.04559001
61	MP0005195_abnormal_posterior_eye	1.02009215
62	MP0000427_abnormal_hair_cycle	1.01251045
63	MP0002067_abnormal_sensory_capabilities	0.99731013
64	MP0005367_renal/urinary_system_phenotyp	0.92285872
65	MP0000516_abnormal_urinary_system	0.92285872
66	MP0010094_abnormal_chromosome_stability	0.91512327
67	MP0003861_abnormal_nervous_system	0.90872438
68	MP0002572_abnormal_emotion/affect_behav	0.88396267
69	MP0001984_abnormal_olfaction	0.84892091
70	MP0005646_abnormal_pituitary_gland	0.84885470
71	MP0003122_maternal_imprinting	0.84413149
72	MP0005391_vision/eye_phenotype	0.84105009
73	MP0002734_abnormal_mechanical_nocicepti	0.83097500
74	MP0002752_abnormal_somatic_nervous	0.82402241
75	MP0005410_abnormal_fertilization	0.81660449
76	MP0002177_abnormal_outer_ear	0.81566638
77	MP0002557_abnormal_social/conspecific_i	0.80748261
78	MP0003938_abnormal_ear_development	0.80112807
79	MP0004043_abnormal_pH_regulation	0.79627608
80	MP0008058_abnormal_DNA_repair	0.79240540
81	MP0002233_abnormal_nose_morphology	0.78799314
82	MP0002063_abnormal_learning/memory/cond	0.78773174
83	MP0001963_abnormal_hearing_physiology	0.77621480
84	MP0002069_abnormal_eating/drinking_beha	0.77485678
85	MP0003635_abnormal_synaptic_transmissio	0.73842763
86	MP0002876_abnormal_thyroid_physiology	0.73217499
87	MP0000566_synostosis	0.72689209
88	MP0005187_abnormal_penis_morphology	0.72664045
89	MP0009703_decreased_birth_body	0.71478298
90	MP0002116_abnormal_craniofacial_bone	0.70987165
91	MP0002882_abnormal_neuron_morphology	0.70152180
92	MP0006138_congestive_heart_failure	0.70131946
93	MP0005620_abnormal_muscle_contractility	0.68503311
94	MP0002152_abnormal_brain_morphology	0.67331199
95	MP0009250_abnormal_appendicular_skeleto	0.65946677
96	MP0000749_muscle_degeneration	0.65057004
97	MP0003119_abnormal_digestive_system	0.64785602
98	MP0005171_absent_coat_pigmentation	0.63789615
99	MP0004085_abnormal_heartbeat	0.63768597
100	MP0002109_abnormal_limb_morphology	0.63339093

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal hair whorl (HP:0010721)	4.29253096
2	Volvulus (HP:0002580)	4.17861501
3	True hermaphroditism (HP:0010459)	3.89614830
4	Pancreatic fibrosis (HP:0100732)	3.74680218
5	Intestinal atresia (HP:0011100)	3.66197051
6	Rectal fistula (HP:0100590)	3.50889021
7	Rectovaginal fistula (HP:0000143)	3.50889021
8	Pancreatic cysts (HP:0001737)	3.36246739
9	Adactyly (HP:0009776)	3.33886209
10	Abnormality of midbrain morphology (HP:0002418)	3.33222356
11	Molar tooth sign on MRI (HP:0002419)	3.33222356
12	Fair hair (HP:0002286)	3.19009514
13	Gaze-evoked nystagmus (HP:0000640)	3.18802036
14	Congenital stationary night blindness (HP:0007642)	3.14029591
15	Hyperglycinemia (HP:0002154)	3.02740420
16	Skull defect (HP:0001362)	2.97962346
17	Hypoproteinemia (HP:0003075)	2.93828872
18	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.93275610
19	Progressive cerebellar ataxia (HP:0002073)	2.90985093
20	Intestinal fistula (HP:0100819)	2.87118889
21	Genital tract atresia (HP:0001827)	2.86696597
22	Nephronophthisis (HP:0000090)	2.85906609
23	Vaginal fistula (HP:0004320)	2.85173751
24	Chronic hepatic failure (HP:0100626)	2.81657501
25	Oligodactyly (hands) (HP:0001180)	2.78944752
26	Hyperventilation (HP:0002883)	2.77816793
27	Long nose (HP:0003189)	2.77505472
28	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.76063803
29	Septate vagina (HP:0001153)	2.67992445
30	Vaginal atresia (HP:0000148)	2.66987684
31	Abnormality of the renal medulla (HP:0100957)	2.66649299
32	Horizontal nystagmus (HP:0000666)	2.60501496
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.55943440
34	Abnormality of alanine metabolism (HP:0010916)	2.55943440
35	Hyperalaninemia (HP:0003348)	2.55943440
36	Broad-based gait (HP:0002136)	2.52728443
37	Hypochromic microcytic anemia (HP:0004840)	2.49113442
38	Hyperlipoproteinemia (HP:0010980)	2.45849875
39	Medial flaring of the eyebrow (HP:0010747)	2.43288309
40	Congenital hepatic fibrosis (HP:0002612)	2.43074195
41	Gait imbalance (HP:0002141)	2.40233767
42	Generalized hypopigmentation of hair (HP:0011358)	2.38734638
43	2-3 toe syndactyly (HP:0004691)	2.38086804
44	Congenital primary aphakia (HP:0007707)	2.36895810
45	Renal hypoplasia (HP:0000089)	2.36352814
46	Progressive inability to walk (HP:0002505)	2.35605932
47	Gastrointestinal atresia (HP:0002589)	2.32098015
48	Hypoplasia of the pons (HP:0012110)	2.31519306
49	Colon cancer (HP:0003003)	2.30611776
50	Renal cortical cysts (HP:0000803)	2.29454611
51	Methylmalonic acidemia (HP:0002912)	2.28905085
52	Gastroesophageal reflux (HP:0002020)	2.26397119
53	Cystic liver disease (HP:0006706)	2.26379752
54	Abnormality of the renal cortex (HP:0011035)	2.21603397
55	Glioma (HP:0009733)	2.21006194
56	Bifid tongue (HP:0010297)	2.20131919
57	Hyperglycinuria (HP:0003108)	2.19854706
58	Preaxial hand polydactyly (HP:0001177)	2.19393201
59	Anteriorly placed anus (HP:0001545)	2.18705710
60	Supernumerary spleens (HP:0009799)	2.17476846
61	Abnormality of serum amino acid levels (HP:0003112)	2.13045469
62	Preaxial foot polydactyly (HP:0001841)	2.12892883
63	Absent hand (HP:0004050)	2.12743771
64	Postaxial foot polydactyly (HP:0001830)	2.12324552
65	Clitoromegaly (HP:0000057)	2.11112225
66	Focal motor seizures (HP:0011153)	2.08435405
67	Astrocytoma (HP:0009592)	2.05353341
68	Abnormality of the astrocytes (HP:0100707)	2.05353341
69	Male pseudohermaphroditism (HP:0000037)	2.05315044
70	Abnormality of the pons (HP:0007361)	2.04708547
71	Abnormality of the labia minora (HP:0012880)	2.01875359
72	Ependymoma (HP:0002888)	2.01800564
73	Cupped ear (HP:0000378)	2.00909250
74	Postaxial hand polydactyly (HP:0001162)	1.99937094
75	Nephrogenic diabetes insipidus (HP:0009806)	1.98677500
76	Short tibia (HP:0005736)	1.96737692
77	Pendular nystagmus (HP:0012043)	1.96686870
78	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.92908153
79	Narrow forehead (HP:0000341)	1.92630468
80	Widely spaced teeth (HP:0000687)	1.91509402
81	Sclerocornea (HP:0000647)	1.91506998
82	Anal atresia (HP:0002023)	1.90190999
83	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.84654304
84	Aplasia cutis congenita (HP:0001057)	1.84505227
85	Palpebral edema (HP:0100540)	1.83676921
86	Inability to walk (HP:0002540)	1.82509407
87	Focal seizures (HP:0007359)	1.82004818
88	Conical tooth (HP:0000698)	1.81000392
89	Abnormality of glycine metabolism (HP:0010895)	1.80476554
90	Abnormality of serine family amino acid metabolism (HP:0010894)	1.80476554
91	Absent speech (HP:0001344)	1.80083558
92	Abnormal lung lobation (HP:0002101)	1.79279717
93	Methylmalonic aciduria (HP:0012120)	1.78471109
94	Furrowed tongue (HP:0000221)	1.77649126
95	Chorioretinal atrophy (HP:0000533)	1.75670881
96	Patellar aplasia (HP:0006443)	1.73671359
97	Occipital encephalocele (HP:0002085)	1.73097235
98	Hypoplastic nipples (HP:0002557)	1.72783729
99	Median cleft lip (HP:0000161)	1.72571697
100	Abnormality of the nasolacrimal system (HP:0000614)	1.72282735

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.95300639
2	WNK3	3.90171969
3	BMPR1B	2.85868019
4	NUAK1	2.68054222
5	PIK3CA	2.67594346
6	MAPK13	2.67070711
7	ACVR1B	2.65770263
8	PKN1	2.32427793
9	TRIM28	2.29947509
10	BCR	2.26109096
11	MKNK2	2.16009770
12	BUB1	2.06395130
13	EPHA3	2.03216182
14	CASK	1.96449678
15	MAP3K4	1.96373222
16	ADRBK2	1.77452650
17	PAK3	1.75448194
18	MKNK1	1.73371630
19	MARK1	1.69383763
20	MAP2K7	1.59604191
21	MAP4K2	1.47496213
22	TNIK	1.46965135
23	CSNK1G1	1.46310234
24	CSNK1G2	1.43811227
25	EIF2AK3	1.39474641
26	PINK1	1.39119070
27	BRSK2	1.35992308
28	GRK1	1.30826368
29	CSNK1G3	1.28468536
30	ERBB3	1.26753287
31	AKT3	1.22864924
32	FGFR2	1.17392475
33	EPHA4	1.16586376
34	STK3	1.15474491
35	TGFBR1	1.11438155
36	PLK3	1.10364049
37	CSNK1A1L	1.09539784
38	WEE1	1.09515048
39	FER	1.08442012
40	PLK4	0.96493431
41	IRAK1	0.96235631
42	PRKCE	0.94247457
43	PDK2	0.93914757
44	CAMKK2	0.92542213
45	VRK1	0.91098234
46	STK16	0.88131515
47	OXSR1	0.87944860
48	PLK2	0.86075545
49	CDK19	0.85782244
50	ERBB2	0.82029939
51	ZAK	0.81745388
52	TIE1	0.80733175
53	DYRK2	0.78978357
54	PNCK	0.77604997
55	ADRBK1	0.77302374
56	DYRK3	0.76295501
57	MINK1	0.75413097
58	CDK3	0.74813137
59	PHKG1	0.71628811
60	PHKG2	0.71628811
61	PRKCG	0.69843760
62	OBSCN	0.69047928
63	ROCK1	0.68819611
64	MAP2K4	0.63848695
65	TAOK3	0.63801296
66	NEK6	0.62034696
67	CAMK2A	0.61108029
68	SGK2	0.60880881
69	CAMK1	0.58343298
70	CSNK1D	0.55926654
71	MST4	0.55026459
72	PLK1	0.53574477
73	FGFR1	0.53488256
74	MAP3K7	0.53349396
75	CDK5	0.49553710
76	STK39	0.49552782
77	YES1	0.46793848
78	VRK2	0.46611802
79	CHEK2	0.46159866
80	RPS6KA4	0.44254942
81	CSNK1A1	0.43765472
82	PRKACA	0.42899818
83	DAPK2	0.41092231
84	SRPK1	0.40711251
85	PRKAA2	0.40698078
86	FGR	0.39246131
87	NTRK3	0.35822882
88	GRK5	0.35281886
89	NEK1	0.34713213
90	CDK1	0.34041856
91	EGFR	0.33581204
92	SGK223	0.33398857
93	SGK494	0.33398857
94	GSK3B	0.33347574
95	EIF2AK2	0.32970504
96	PRKACG	0.32562117
97	ATM	0.32106860
98	CDC7	0.32039462
99	PRKG1	0.31679771
100	ATR	0.30691535

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.23270678
2	Phototransduction_Homo sapiens_hsa04744	3.19729325
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.90563411
4	Propanoate metabolism_Homo sapiens_hsa00640	2.42615030
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.39579779
6	Caffeine metabolism_Homo sapiens_hsa00232	2.28781275
7	Nicotine addiction_Homo sapiens_hsa05033	2.19697805
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.16479970
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.14180490
10	Butanoate metabolism_Homo sapiens_hsa00650	2.02948681
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90361275
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.88467652
13	Non-homologous end-joining_Homo sapiens_hsa03450	1.87257154
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79182015
15	Olfactory transduction_Homo sapiens_hsa04740	1.73801944
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.69731785
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.69297518
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64024365
19	Homologous recombination_Homo sapiens_hsa03440	1.55846430
20	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.55719465
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55488984
22	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.53625024
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.47508247
24	Protein export_Homo sapiens_hsa03060	1.46158812
25	RNA degradation_Homo sapiens_hsa03018	1.45480996
26	Basal transcription factors_Homo sapiens_hsa03022	1.43950128
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.35873574
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.32374352
29	ABC transporters_Homo sapiens_hsa02010	1.31518303
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.31028500
31	Regulation of autophagy_Homo sapiens_hsa04140	1.30257324
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.29078205
33	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.25371973
34	Oocyte meiosis_Homo sapiens_hsa04114	1.25114880
35	Taste transduction_Homo sapiens_hsa04742	1.23611268
36	Morphine addiction_Homo sapiens_hsa05032	1.22902760
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.12724523
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.11100578
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10978629
40	Lysine degradation_Homo sapiens_hsa00310	1.07486488
41	RNA polymerase_Homo sapiens_hsa03020	0.98808973
42	Fat digestion and absorption_Homo sapiens_hsa04975	0.98731081
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98337584
44	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.97968241
45	Circadian rhythm_Homo sapiens_hsa04710	0.97126586
46	Cell cycle_Homo sapiens_hsa04110	0.95807350
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95737181
48	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.95415985
49	Cocaine addiction_Homo sapiens_hsa05030	0.94591860
50	GABAergic synapse_Homo sapiens_hsa04727	0.92763206
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92726260
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91421961
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90991707
54	Peroxisome_Homo sapiens_hsa04146	0.90773838
55	Basal cell carcinoma_Homo sapiens_hsa05217	0.90404360
56	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.88912660
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.86619417
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.86417448
59	One carbon pool by folate_Homo sapiens_hsa00670	0.84494182
60	Tight junction_Homo sapiens_hsa04530	0.82563124
61	RNA transport_Homo sapiens_hsa03013	0.81538070
62	Circadian entrainment_Homo sapiens_hsa04713	0.80749179
63	Hippo signaling pathway_Homo sapiens_hsa04390	0.77041852
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76319549
65	Amphetamine addiction_Homo sapiens_hsa05031	0.75930621
66	Wnt signaling pathway_Homo sapiens_hsa04310	0.75870449
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.75758119
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74375671
69	Serotonergic synapse_Homo sapiens_hsa04726	0.74187932
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.74038706
71	Purine metabolism_Homo sapiens_hsa00230	0.73355765
72	p53 signaling pathway_Homo sapiens_hsa04115	0.71245145
73	Long-term depression_Homo sapiens_hsa04730	0.68849656
74	Retinol metabolism_Homo sapiens_hsa00830	0.68533353
75	Fatty acid elongation_Homo sapiens_hsa00062	0.66084113
76	Proteasome_Homo sapiens_hsa03050	0.61950899
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59216539
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58544714
79	Mismatch repair_Homo sapiens_hsa03430	0.56722106
80	Axon guidance_Homo sapiens_hsa04360	0.56645802
81	Glutathione metabolism_Homo sapiens_hsa00480	0.56557601
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.55057438
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.53741483
84	Insulin secretion_Homo sapiens_hsa04911	0.53465779
85	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.53317801
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.53184710
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.51213099
88	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.50874203
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47297963
90	Parkinsons disease_Homo sapiens_hsa05012	0.46561703
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45718291
92	Metabolic pathways_Homo sapiens_hsa01100	0.44787958
93	Oxidative phosphorylation_Homo sapiens_hsa00190	0.44548124
94	Huntingtons disease_Homo sapiens_hsa05016	0.42496376
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41874887
96	PPAR signaling pathway_Homo sapiens_hsa03320	0.41707783
97	Gastric acid secretion_Homo sapiens_hsa04971	0.41213053
98	mRNA surveillance pathway_Homo sapiens_hsa03015	0.40844160
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40390144
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.39595518

SUCLA2P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »