ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to gravity (GO:0009629)	6.38657013
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.44147848
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.44147848
4	adenosine metabolic process (GO:0046085)	5.38102019
5	platelet dense granule organization (GO:0060155)	5.33359792
6	regulation of memory T cell differentiation (GO:0043380)	5.17480716
7	regulation of plasminogen activation (GO:0010755)	5.11873008
8	muscle atrophy (GO:0014889)	5.05771208
9	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.93455034
10	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	4.90575670
11	negative regulation of cell killing (GO:0031342)	4.90575670
12	negative regulation of Ras GTPase activity (GO:0034261)	4.88128047
13	homocysteine metabolic process (GO:0050667)	4.86546766
14	artery smooth muscle contraction (GO:0014824)	4.74422357
15	white fat cell differentiation (GO:0050872)	4.74126370
16	adult feeding behavior (GO:0008343)	4.71460284
17	alternative mRNA splicing, via spliceosome (GO:0000380)	4.69989260
18	cellular response to interleukin-15 (GO:0071350)	4.51099056
19	adaptation of signaling pathway (GO:0023058)	4.50990088
20	striated muscle atrophy (GO:0014891)	4.43656596
21	folic acid-containing compound biosynthetic process (GO:0009396)	4.34195820
22	skeletal muscle adaptation (GO:0043501)	4.31185683
23	negative regulation of interleukin-1 beta production (GO:0032691)	4.28265941
24	regulation of T cell mediated cytotoxicity (GO:0001914)	4.18251722
25	cysteine metabolic process (GO:0006534)	4.07843416
26	purine nucleotide salvage (GO:0032261)	4.07386991
27	sulfur amino acid catabolic process (GO:0000098)	4.06197425
28	regulation of activation of Janus kinase activity (GO:0010533)	3.99998072
29	tonic smooth muscle contraction (GO:0014820)	3.98466773
30	desmosome organization (GO:0002934)	3.97155088
31	positive regulation of endothelial cell differentiation (GO:0045603)	3.92409492
32	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.84312575
33	interleukin-6-mediated signaling pathway (GO:0070102)	3.83797001
34	regulation of sequestering of triglyceride (GO:0010889)	3.80627009
35	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.69445698
36	negative regulation of interleukin-1 production (GO:0032692)	3.60658343
37	microtubule nucleation (GO:0007020)	3.55463594
38	positive regulation of glycolytic process (GO:0045821)	3.53256672
39	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.43964209
40	response to muscle activity (GO:0014850)	3.43597251
41	negative regulation of DNA biosynthetic process (GO:2000279)	3.40656151
42	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.29511997
43	skeletal muscle tissue regeneration (GO:0043403)	3.29428589
44	negative regulation of acute inflammatory response (GO:0002674)	3.28537431
45	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.26433404
46	T-helper cell differentiation (GO:0042093)	3.25209506
47	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	3.25209506
48	negative regulation of lipid storage (GO:0010888)	3.23066698
49	hair cycle (GO:0042633)	3.21362115
50	molting cycle (GO:0042303)	3.21362115
51	negative regulation of T cell mediated immunity (GO:0002710)	3.21064424
52	phenylpropanoid metabolic process (GO:0009698)	3.20792359
53	endocrine pancreas development (GO:0031018)	3.17990502
54	response to interleukin-15 (GO:0070672)	3.13546533
55	primary amino compound metabolic process (GO:1901160)	3.09013640
56	kynurenine metabolic process (GO:0070189)	3.08370798
57	regulation of endothelial cell differentiation (GO:0045601)	3.03016794
58	inner ear receptor cell development (GO:0060119)	3.02789507
59	vascular smooth muscle contraction (GO:0014829)	2.99242379
60	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.98823892
61	negative regulation of NF-kappaB import into nucleus (GO:0042347)	2.96153234
62	regulation of vitamin D biosynthetic process (GO:0060556)	2.96148173
63	regulation of germinal center formation (GO:0002634)	2.93192577
64	response to lipoprotein particle (GO:0055094)	2.93038198
65	protein-chromophore linkage (GO:0018298)	2.91619181
66	positive regulation of histone acetylation (GO:0035066)	2.90863833
67	positive regulation of defense response to virus by host (GO:0002230)	2.90645854
68	energy homeostasis (GO:0097009)	2.89740869
69	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.87576503
70	cytidine deamination (GO:0009972)	2.82796728
71	cytidine metabolic process (GO:0046087)	2.82796728
72	cytidine catabolic process (GO:0006216)	2.82796728
73	organic cation transport (GO:0015695)	2.82248489
74	positive regulation of T cell differentiation in thymus (GO:0033089)	2.81701282
75	pteridine-containing compound biosynthetic process (GO:0042559)	2.80998618
76	regulation of gonadotropin secretion (GO:0032276)	2.80449810
77	galactose metabolic process (GO:0006012)	2.80253706
78	galactose catabolic process (GO:0019388)	2.77003749
79	T cell differentiation involved in immune response (GO:0002292)	2.76791514
80	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.76791514
81	alpha-beta T cell activation involved in immune response (GO:0002287)	2.76791514
82	inositol phosphate-mediated signaling (GO:0048016)	2.72779916
83	ceramide catabolic process (GO:0046514)	2.72745428
84	negative regulation of muscle hypertrophy (GO:0014741)	2.68529181
85	mitochondrial RNA metabolic process (GO:0000959)	2.67289039
86	nucleoside transmembrane transport (GO:1901642)	2.61786588
87	neutrophil activation (GO:0042119)	2.59384869
88	regulation of tight junction assembly (GO:2000810)	2.59303465
89	positive regulation of protein acetylation (GO:1901985)	2.58173722
90	positive regulation of peptidyl-lysine acetylation (GO:2000758)	2.58173722
91	negative regulation of skeletal muscle tissue development (GO:0048642)	2.57825651
92	reciprocal DNA recombination (GO:0035825)	2.57284074
93	reciprocal meiotic recombination (GO:0007131)	2.57284074
94	positive regulation of heat generation (GO:0031652)	2.57094879
95	COPII vesicle coating (GO:0048208)	2.56496956
96	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.56291024
97	cellular response to leptin stimulus (GO:0044320)	2.53847810
98	cellular ketone body metabolic process (GO:0046950)	2.52079844
99	preassembly of GPI anchor in ER membrane (GO:0016254)	2.51728122
100	positive regulation of cell fate commitment (GO:0010455)	2.49597619

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.44884891
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.61029207
3	VDR_22108803_ChIP-Seq_LS180_Human	4.55995183
4	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.08378088
5	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.76897830
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.55297462
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.38616165
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.36749981
9	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.25322000
10	ER_23166858_ChIP-Seq_MCF-7_Human	2.23112427
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22172321
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.09449972
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00279880
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.88362214
15	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85458885
16	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.84625380
17	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.84397901
18	TP53_22573176_ChIP-Seq_HFKS_Human	1.75334016
19	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.73358028
20	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.68972179
21	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.67900348
22	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.65313585
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.59747678
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.56068535
25	RUNX_20019798_ChIP-Seq_JUKART_Human	1.54965579
26	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53683194
27	FUS_26573619_Chip-Seq_HEK293_Human	1.52684747
28	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.47586575
29	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.47304389
30	CDX2_22108803_ChIP-Seq_LS180_Human	1.45913512
31	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.44156468
32	ZNF274_21170338_ChIP-Seq_K562_Hela	1.43383233
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39288789
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.35332702
35	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.32060022
36	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.29956813
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.29767477
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.29426090
39	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.26408280
40	STAT3_23295773_ChIP-Seq_U87_Human	1.24101892
41	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.22614212
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.22132685
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.20406032
44	NCOR_22424771_ChIP-Seq_293T_Human	1.19999664
45	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.18502653
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18353385
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.17978144
48	P300_19829295_ChIP-Seq_ESCs_Human	1.13782819
49	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.13202511
50	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12874478
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12781736
52	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.12434808
53	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.11437491
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.11363490
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11363490
56	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.10655199
57	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.10532516
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09131461
59	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07322335
60	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.06887127
61	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.06307906
62	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.05625663
63	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04303783
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03805527
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03805527
66	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03482644
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03242252
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03242252
69	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02676525
70	STAT1_20625510_ChIP-Seq_HELA_Human	1.02670318
71	GATA3_26560356_Chip-Seq_TH2_Human	1.02296512
72	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02135195
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00861750
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99863574
75	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.99226150
76	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.98475314
77	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98158389
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97144056
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97125189
80	VDR_24787735_ChIP-Seq_THP-1_Human	0.95516018
81	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.95504998
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94380250
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93671120
84	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.93644731
85	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.92767903
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.91779020
87	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.91497610
88	PHF8_20622853_ChIP-Seq_HELA_Human	0.91188269
89	AR_20517297_ChIP-Seq_VCAP_Human	0.90049466
90	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.89291728
91	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.89155019
92	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.89134724
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.88741361
94	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.88133964
95	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.86867839
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.85934730
97	TBL1_22424771_ChIP-Seq_293T_Human	0.85797094
98	HTT_18923047_ChIP-ChIP_STHdh_Human	0.84751714
99	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.84199737
100	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.83320216

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003724_increased_susceptibility_to	4.69688277
2	MP0005670_abnormal_white_adipose	4.49341817
3	MP0000013_abnormal_adipose_tissue	3.40425888
4	MP0008995_early_reproductive_senescence	2.73426695
5	MP0002736_abnormal_nociception_after	2.69038696
6	MP0005360_urolithiasis	2.44995097
7	MP0004885_abnormal_endolymph	2.44061434
8	MP0003787_abnormal_imprinting	2.39779805
9	MP0005646_abnormal_pituitary_gland	2.36542745
10	MP0008877_abnormal_DNA_methylation	2.23389772
11	MP0008872_abnormal_physiological_respon	2.22276781
12	MP0003011_delayed_dark_adaptation	2.09038641
13	MP0004147_increased_porphyrin_level	2.02982827
14	MP0003195_calcinosis	1.97977401
15	MP0002822_catalepsy	1.97397569
16	MP0002837_dystrophic_cardiac_calcinosis	1.88987249
17	MP0001968_abnormal_touch/_nociception	1.88195721
18	MP0001986_abnormal_taste_sensitivity	1.82670082
19	MP0004043_abnormal_pH_regulation	1.80731658
20	MP0001661_extended_life_span	1.80138156
21	MP0006072_abnormal_retinal_apoptosis	1.68382951
22	MP0002396_abnormal_hematopoietic_system	1.61278642
23	MP0000516_abnormal_urinary_system	1.59203085
24	MP0005367_renal/urinary_system_phenotyp	1.59203085
25	MP0003183_abnormal_peptide_metabolism	1.53358547
26	MP0001533_abnormal_skeleton_physiology	1.49713543
27	MP0005551_abnormal_eye_electrophysiolog	1.48269610
28	MP0005645_abnormal_hypothalamus_physiol	1.48170747
29	MP0002938_white_spotting	1.47686615
30	MP0000427_abnormal_hair_cycle	1.46451470
31	MP0005332_abnormal_amino_acid	1.45595599
32	MP0005253_abnormal_eye_physiology	1.44092745
33	MP0003705_abnormal_hypodermis_morpholog	1.43014548
34	MP0002139_abnormal_hepatobiliary_system	1.42184093
35	MP0001270_distended_abdomen	1.41487242
36	MP0002254_reproductive_system_inflammat	1.40526693
37	MP0005085_abnormal_gallbladder_physiolo	1.39550909
38	MP0003646_muscle_fatigue	1.36180442
39	MP0002009_preneoplasia	1.34139318
40	MP0002693_abnormal_pancreas_physiology	1.33742049
41	MP0002876_abnormal_thyroid_physiology	1.32388817
42	MP0002735_abnormal_chemical_nociception	1.27377968
43	MP0000465_gastrointestinal_hemorrhage	1.27177204
44	MP0003252_abnormal_bile_duct	1.25694909
45	MP0001944_abnormal_pancreas_morphology	1.23103793
46	MP0004145_abnormal_muscle_electrophysio	1.22482007
47	MP0000383_abnormal_hair_follicle	1.21912449
48	MP0000003_abnormal_adipose_tissue	1.20276688
49	MP0000747_muscle_weakness	1.18773112
50	MP0010329_abnormal_lipoprotein_level	1.17936534
51	MP0003638_abnormal_response/metabolism_	1.15714921
52	MP0002332_abnormal_exercise_endurance	1.15066533
53	MP0010678_abnormal_skin_adnexa	1.14164627
54	MP0005448_abnormal_energy_balance	1.13860728
55	MP0002078_abnormal_glucose_homeostasis	1.13409389
56	MP0002933_joint_inflammation	1.12635023
57	MP0001851_eye_inflammation	1.12267685
58	MP0004019_abnormal_vitamin_homeostasis	1.11892181
59	MP0009765_abnormal_xenobiotic_induced	1.11518558
60	MP0008961_abnormal_basal_metabolism	1.10902740
61	MP0004036_abnormal_muscle_relaxation	1.09728931
62	MP0003786_premature_aging	1.08861453
63	MP0001765_abnormal_ion_homeostasis	1.07613091
64	MP0005377_hearing/vestibular/ear_phenot	1.05826780
65	MP0003878_abnormal_ear_physiology	1.05826780
66	MP0001486_abnormal_startle_reflex	1.05725597
67	MP0002971_abnormal_brown_adipose	1.02881636
68	MP0003436_decreased_susceptibility_to	1.02831838
69	MP0004133_heterotaxia	1.01713939
70	MP0009780_abnormal_chondrocyte_physiolo	1.00411177
71	MP0004130_abnormal_muscle_cell	0.99698363
72	MP0002269_muscular_atrophy	0.98470835
73	MP0003045_fibrosis	0.97964966
74	MP0005535_abnormal_body_temperature	0.97893896
75	MP0002638_abnormal_pupillary_reflex	0.95989908
76	MP0008775_abnormal_heart_ventricle	0.92997354
77	MP0001502_abnormal_circadian_rhythm	0.90841228
78	MP0005671_abnormal_response_to	0.88274467
79	MP0000371_diluted_coat_color	0.86684016
80	MP0005167_abnormal_blood-brain_barrier	0.86083181
81	MP0002069_abnormal_eating/drinking_beha	0.84935876
82	MP0001501_abnormal_sleep_pattern	0.84161162
83	MP0008004_abnormal_stomach_pH	0.84091434
84	MP0005386_behavior/neurological_phenoty	0.80496678
85	MP0004924_abnormal_behavior	0.80496678
86	MP0009764_decreased_sensitivity_to	0.80192852
87	MP0003953_abnormal_hormone_level	0.79824314
88	MP0000230_abnormal_systemic_arterial	0.79356583
89	MP0005636_abnormal_mineral_homeostasis	0.78958076
90	MP0002118_abnormal_lipid_homeostasis	0.78423525
91	MP0005000_abnormal_immune_tolerance	0.77938535
92	MP0009115_abnormal_fat_cell	0.77573253
93	MP0000631_abnormal_neuroendocrine_gland	0.76388148
94	MP0001919_abnormal_reproductive_system	0.76222934
95	MP0002138_abnormal_hepatobiliary_system	0.76160236
96	MP0005334_abnormal_fat_pad	0.72722930
97	MP0005164_abnormal_response_to	0.70978794
98	MP0001529_abnormal_vocalization	0.69450086
99	MP0005620_abnormal_muscle_contractility	0.68976516
100	MP0000749_muscle_degeneration	0.68811627

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	5.68860829
2	Abnormality of alanine metabolism (HP:0010916)	5.68860829
3	Hyperalaninemia (HP:0003348)	5.68860829
4	Congenital sensorineural hearing impairment (HP:0008527)	4.41172817
5	Myositis (HP:0100614)	4.19201090
6	Optic neuritis (HP:0100653)	3.97906799
7	Retrobulbar optic neuritis (HP:0100654)	3.97906799
8	White forelock (HP:0002211)	3.80667455
9	Constricted visual fields (HP:0001133)	3.69839709
10	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.67715146
11	Orchitis (HP:0100796)	3.59131310
12	Spontaneous hematomas (HP:0007420)	3.51080486
13	Anorexia (HP:0002039)	3.50528754
14	Myopathic facies (HP:0002058)	3.36689313
15	Action tremor (HP:0002345)	3.33843649
16	Hyperglycemia (HP:0003074)	3.30174971
17	Patchy hypopigmentation of hair (HP:0011365)	3.26452252
18	Esophageal varix (HP:0002040)	3.19251896
19	Short tibia (HP:0005736)	3.13215966
20	Delayed CNS myelination (HP:0002188)	3.09549687
21	Pulmonary embolism (HP:0002204)	3.06540569
22	Abnormality of homocysteine metabolism (HP:0010919)	3.03898917
23	Homocystinuria (HP:0002156)	3.03898917
24	Myocardial infarction (HP:0001658)	2.97280050
25	Severe combined immunodeficiency (HP:0004430)	2.91885955
26	Hypoalphalipoproteinemia (HP:0003233)	2.90434332
27	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.86118998
28	Intestinal atresia (HP:0011100)	2.72601276
29	Hyperlipoproteinemia (HP:0010980)	2.71520799
30	Thyroiditis (HP:0100646)	2.70238331
31	Pigmentary retinal degeneration (HP:0001146)	2.54290333
32	Stomatitis (HP:0010280)	2.46800796
33	Chronic hepatic failure (HP:0100626)	2.46782475
34	Poor speech (HP:0002465)	2.45339479
35	Hematochezia (HP:0002573)	2.44007510
36	Keratoconjunctivitis (HP:0001096)	2.42922464
37	Oligomenorrhea (HP:0000876)	2.41847197
38	Keratoconjunctivitis sicca (HP:0001097)	2.41472320
39	Elevated erythrocyte sedimentation rate (HP:0003565)	2.39319347
40	Hemoptysis (HP:0002105)	2.38206914
41	Arterial thrombosis (HP:0004420)	2.31958142
42	Abnormality of the fetal cardiovascular system (HP:0010948)	2.31269402
43	Abnormal umbilical cord blood vessels (HP:0011403)	2.31269402
44	Single umbilical artery (HP:0001195)	2.31269402
45	Fibular hypoplasia (HP:0003038)	2.30829074
46	Ketoacidosis (HP:0001993)	2.29282798
47	Insulin-resistant diabetes mellitus (HP:0000831)	2.28397074
48	Abnormal pupillary function (HP:0007686)	2.27167200
49	Abolished electroretinogram (ERG) (HP:0000550)	2.25304945
50	Brittle hair (HP:0002299)	2.24052353
51	Neoplasm of the heart (HP:0100544)	2.23351846
52	Generalized aminoaciduria (HP:0002909)	2.18515931
53	Combined immunodeficiency (HP:0005387)	2.16725022
54	Pendular nystagmus (HP:0012043)	2.16034516
55	Abnormality of eosinophils (HP:0001879)	2.08828701
56	Conjugated hyperbilirubinemia (HP:0002908)	2.08654533
57	Maternal diabetes (HP:0009800)	2.08216691
58	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.06852972
59	Anteriorly placed anus (HP:0001545)	2.06271229
60	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.05277553
61	Granulocytopenia (HP:0001913)	2.01591303
62	Tubulointerstitial nephritis (HP:0001970)	2.00046449
63	Hyperphosphatemia (HP:0002905)	1.98907509
64	Agitation (HP:0000713)	1.98424201
65	Metaphyseal dysplasia (HP:0100255)	1.97452708
66	Chorioretinal atrophy (HP:0000533)	1.96711204
67	Heterochromia iridis (HP:0001100)	1.95479852
68	Gingival bleeding (HP:0000225)	1.93962620
69	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.91273986
70	Congenital stationary night blindness (HP:0007642)	1.90902653
71	Abnormality of the parietal bone (HP:0002696)	1.89962491
72	Pancreatic fibrosis (HP:0100732)	1.87173256
73	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.86867814
74	True hermaphroditism (HP:0010459)	1.84027754
75	Pancreatitis (HP:0001733)	1.83046272
76	Attenuation of retinal blood vessels (HP:0007843)	1.82447791
77	Pancreatic cysts (HP:0001737)	1.81777471
78	Epidermoid cyst (HP:0200040)	1.81348627
79	T lymphocytopenia (HP:0005403)	1.80654784
80	Palpebral edema (HP:0100540)	1.77510392
81	Abnormality of serum amino acid levels (HP:0003112)	1.77134362
82	Prolonged QT interval (HP:0001657)	1.73804919
83	Portal hypertension (HP:0001409)	1.73535004
84	Episodic fever (HP:0001954)	1.73371840
85	Severe visual impairment (HP:0001141)	1.71558857
86	Conjunctival telangiectasia (HP:0000524)	1.71196420
87	Nemaline bodies (HP:0003798)	1.70200473
88	Conical tooth (HP:0000698)	1.70110414
89	Metabolic acidosis (HP:0001942)	1.69355771
90	Petechiae (HP:0000967)	1.68049927
91	Hyperphosphaturia (HP:0003109)	1.67019628
92	Pustule (HP:0200039)	1.66355596
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.66275988
94	Vascular calcification (HP:0004934)	1.65739139
95	Albinism (HP:0001022)	1.63954868
96	Disproportionate short-trunk short stature (HP:0003521)	1.63383207
97	Chronic otitis media (HP:0000389)	1.62809773
98	Hypolipoproteinemia (HP:0010981)	1.62315741
99	Abnormality of lateral ventricle (HP:0030047)	1.61798306
100	Hyperkalemia (HP:0002153)	1.61444834

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K3	3.50222286
2	MAP4K2	3.38823124
3	FRK	3.17879967
4	MAP2K3	3.17538588
5	TLK1	2.59141024
6	JAK3	2.56056216
7	TAOK3	2.49019162
8	MAP3K14	2.42184132
9	TXK	2.39691516
10	ACVR1B	2.18295384
11	NUAK1	2.16621109
12	PHKG2	2.15666502
13	PHKG1	2.15666502
14	ZAK	1.93556210
15	FES	1.85184250
16	IRAK1	1.84591657
17	GRK6	1.82810075
18	IKBKE	1.82036759
19	INSRR	1.81597891
20	BMPR1B	1.56319298
21	LATS1	1.51129293
22	DAPK2	1.50882624
23	IKBKB	1.45517347
24	OBSCN	1.42918417
25	SGK223	1.38380368
26	SGK494	1.38380368
27	GRK1	1.35645726
28	SGK2	1.32834521
29	MET	1.31796851
30	MAP2K2	1.23699839
31	FGFR2	1.21583437
32	MAP4K1	1.21425417
33	FGR	1.20651912
34	JAK1	1.16975885
35	TBK1	1.13488332
36	MAP3K9	1.06955806
37	PAK3	1.02261449
38	STK3	0.99582643
39	NEK6	0.98774613
40	EPHA3	0.95252246
41	MAP2K1	0.94216995
42	TIE1	0.93277009
43	PTK2B	0.92634443
44	SGK3	0.92338418
45	KDR	0.91795850
46	FER	0.90958870
47	RIPK4	0.89920570
48	MATK	0.89658440
49	CDK9	0.84166468
50	CHUK	0.79695506
51	MST4	0.79183067
52	NTRK2	0.79145007
53	PINK1	0.77576177
54	MAP2K6	0.77373738
55	PRKCE	0.74449538
56	IRAK4	0.74404990
57	WNK1	0.72863213
58	ADRBK2	0.72075912
59	MAP3K1	0.71111864
60	FGFR3	0.70225384
61	PIK3CA	0.69778937
62	MKNK2	0.68434066
63	TNK2	0.64051521
64	MAPK7	0.62710390
65	ADRBK1	0.62530272
66	EPHB1	0.62356075
67	NLK	0.62226719
68	MAPK13	0.61539955
69	SYK	0.57404640
70	OXSR1	0.56782869
71	SIK3	0.56469610
72	TNIK	0.56434928
73	YES1	0.54435435
74	ERN1	0.53603193
75	EIF2AK2	0.52045925
76	SGK1	0.51375228
77	SIK1	0.50864192
78	AURKA	0.50800677
79	IRAK2	0.48236572
80	CSNK1A1	0.46881686
81	HCK	0.44239224
82	TEC	0.43645187
83	CAMK1	0.42541859
84	PRKG2	0.40448978
85	LYN	0.37846270
86	PRKCA	0.35772055
87	PRKAA2	0.35732155
88	CSF1R	0.35379058
89	LCK	0.34648958
90	JAK2	0.34319789
91	PIM1	0.32832942
92	STK38	0.32421830
93	PKN1	0.31590953
94	CSNK1D	0.31539376
95	KIT	0.31376910
96	RPS6KA1	0.31330736
97	STK4	0.31162981
98	MARK3	0.30988579
99	CCNB1	0.29911287
100	EGFR	0.29822495

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	5.67809673
2	Arginine biosynthesis_Homo sapiens_hsa00220	3.26456139
3	Collecting duct acid secretion_Homo sapiens_hsa04966	3.25839672
4	Sulfur metabolism_Homo sapiens_hsa00920	3.21301521
5	One carbon pool by folate_Homo sapiens_hsa00670	2.35486318
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.21997500
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.14743987
8	Morphine addiction_Homo sapiens_hsa05032	2.09902809
9	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.04524421
10	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.86988358
11	GABAergic synapse_Homo sapiens_hsa04727	1.86042190
12	Retinol metabolism_Homo sapiens_hsa00830	1.66053200
13	Regulation of autophagy_Homo sapiens_hsa04140	1.61977118
14	Circadian rhythm_Homo sapiens_hsa04710	1.57059709
15	Circadian entrainment_Homo sapiens_hsa04713	1.46655536
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.45619137
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.41903659
18	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.40958189
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38836576
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38200636
21	Caffeine metabolism_Homo sapiens_hsa00232	1.37998176
22	Renin secretion_Homo sapiens_hsa04924	1.33812987
23	Butanoate metabolism_Homo sapiens_hsa00650	1.33653720
24	ABC transporters_Homo sapiens_hsa02010	1.32865787
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.30495257
26	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.26852162
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.25128759
28	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.20518051
29	Dopaminergic synapse_Homo sapiens_hsa04728	1.20484226
30	Olfactory transduction_Homo sapiens_hsa04740	1.15012921
31	Serotonergic synapse_Homo sapiens_hsa04726	1.14223239
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.13883870
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12703364
34	Galactose metabolism_Homo sapiens_hsa00052	1.12514164
35	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.11948532
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10747034
37	Peroxisome_Homo sapiens_hsa04146	1.09159034
38	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.07609182
39	Sphingolipid metabolism_Homo sapiens_hsa00600	1.07362157
40	Nicotine addiction_Homo sapiens_hsa05033	1.03533852
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.03152668
42	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.02036556
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.01570833
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.01550518
45	Homologous recombination_Homo sapiens_hsa03440	1.01320789
46	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.00861233
47	Insulin secretion_Homo sapiens_hsa04911	1.00424587
48	Linoleic acid metabolism_Homo sapiens_hsa00591	1.00319700
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96450634
50	Alcoholism_Homo sapiens_hsa05034	0.92790539
51	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.92057232
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91438193
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.90967776
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.90725545
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.88072817
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.87346265
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.86988623
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83193479
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82920952
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.82039042
61	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.81268552
62	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.80484851
63	Fatty acid elongation_Homo sapiens_hsa00062	0.75699607
64	Oxidative phosphorylation_Homo sapiens_hsa00190	0.71981865
65	Tight junction_Homo sapiens_hsa04530	0.69775162
66	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.69155913
67	Amphetamine addiction_Homo sapiens_hsa05031	0.68339681
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.68261272
69	Cholinergic synapse_Homo sapiens_hsa04725	0.67425957
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.66725434
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66538005
72	Protein export_Homo sapiens_hsa03060	0.66224412
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.64461776
74	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.62907767
75	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.62561175
76	Gastric acid secretion_Homo sapiens_hsa04971	0.62399947
77	Complement and coagulation cascades_Homo sapiens_hsa04610	0.61475574
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.61125241
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.60716862
80	Type I diabetes mellitus_Homo sapiens_hsa04940	0.56628489
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.52729079
82	Folate biosynthesis_Homo sapiens_hsa00790	0.51500758
83	Other glycan degradation_Homo sapiens_hsa00511	0.49590198
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.48100376
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45405116
86	Vibrio cholerae infection_Homo sapiens_hsa05110	0.43925527
87	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.42242941
88	Mineral absorption_Homo sapiens_hsa04978	0.40691895
89	Pertussis_Homo sapiens_hsa05133	0.39154993
90	Taste transduction_Homo sapiens_hsa04742	0.37607303
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37400217
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.36243156
93	Chemokine signaling pathway_Homo sapiens_hsa04062	0.33379699
94	Salivary secretion_Homo sapiens_hsa04970	0.32472060
95	Osteoclast differentiation_Homo sapiens_hsa04380	0.30619391
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29276863
97	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.28153315
98	Phenylalanine metabolism_Homo sapiens_hsa00360	0.27091131
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26881548
100	Renin-angiotensin system_Homo sapiens_hsa04614	0.26504628

SUCLG2P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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