ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	6.92174032
2	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	5.15720979
3	indolalkylamine catabolic process (GO:0046218)	4.36440177
4	tryptophan catabolic process (GO:0006569)	4.36440177
5	indole-containing compound catabolic process (GO:0042436)	4.36440177
6	indolalkylamine metabolic process (GO:0006586)	4.29339727
7	neural tube formation (GO:0001841)	4.26665566
8	reflex (GO:0060004)	4.10184819
9	protein K63-linked deubiquitination (GO:0070536)	4.05939108
10	serotonin receptor signaling pathway (GO:0007210)	4.01330262
11	photoreceptor cell maintenance (GO:0045494)	3.98347621
12	signal peptide processing (GO:0006465)	3.90895702
13	tryptophan metabolic process (GO:0006568)	3.90833044
14	DNA double-strand break processing (GO:0000729)	3.89241835
15	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.85625012
16	tachykinin receptor signaling pathway (GO:0007217)	3.80091138
17	retinal cone cell development (GO:0046549)	3.78789071
18	auditory receptor cell stereocilium organization (GO:0060088)	3.78319600
19	cellular ketone body metabolic process (GO:0046950)	3.77037831
20	thyroid hormone metabolic process (GO:0042403)	3.76263201
21	righting reflex (GO:0060013)	3.72055052
22	detection of light stimulus involved in visual perception (GO:0050908)	3.59800680
23	detection of light stimulus involved in sensory perception (GO:0050962)	3.59800680
24	cilium or flagellum-dependent cell motility (GO:0001539)	3.58493317
25	response to pheromone (GO:0019236)	3.56628458
26	kynurenine metabolic process (GO:0070189)	3.54791482
27	sulfation (GO:0051923)	3.54143248
28	ketone body metabolic process (GO:1902224)	3.46254061
29	startle response (GO:0001964)	3.42179296
30	protein K48-linked deubiquitination (GO:0071108)	3.37423286
31	regulation of sarcomere organization (GO:0060297)	3.30952419
32	replication fork processing (GO:0031297)	3.29235056
33	piRNA metabolic process (GO:0034587)	3.21017487
34	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.20829597
35	inner ear receptor stereocilium organization (GO:0060122)	3.19549698
36	fucose catabolic process (GO:0019317)	3.15075160
37	L-fucose metabolic process (GO:0042354)	3.15075160
38	L-fucose catabolic process (GO:0042355)	3.15075160
39	behavioral response to nicotine (GO:0035095)	3.14903626
40	indole-containing compound metabolic process (GO:0042430)	3.14109940
41	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.11214145
42	gamma-aminobutyric acid transport (GO:0015812)	3.10258917
43	regulation of hippo signaling (GO:0035330)	3.09665053
44	regulation of establishment of cell polarity (GO:2000114)	3.07375778
45	sex differentiation (GO:0007548)	3.07239801
46	lipid translocation (GO:0034204)	2.98774402
47	phospholipid translocation (GO:0045332)	2.98774402
48	regulation of collateral sprouting (GO:0048670)	2.98563700
49	negative regulation of mast cell activation (GO:0033004)	2.98249506
50	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.94312862
51	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.94213213
52	DNA methylation involved in gamete generation (GO:0043046)	2.93168379
53	amine catabolic process (GO:0009310)	2.91086592
54	cellular biogenic amine catabolic process (GO:0042402)	2.91086592
55	flavonoid metabolic process (GO:0009812)	2.90606444
56	establishment of protein localization to Golgi (GO:0072600)	2.88359754
57	regulation of meiosis I (GO:0060631)	2.85525952
58	positive regulation of vasculogenesis (GO:2001214)	2.85110031
59	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.83792586
60	dicarboxylic acid catabolic process (GO:0043649)	2.83067104
61	glycerophospholipid catabolic process (GO:0046475)	2.82784428
62	aromatic amino acid family catabolic process (GO:0009074)	2.82514914
63	killing of cells of other organism (GO:0031640)	2.81547241
64	disruption of cells of other organism (GO:0044364)	2.81547241
65	serotonin metabolic process (GO:0042428)	2.79928162
66	dopamine transport (GO:0015872)	2.79907717
67	cilium morphogenesis (GO:0060271)	2.77718822
68	nonmotile primary cilium assembly (GO:0035058)	2.76699235
69	behavioral response to ethanol (GO:0048149)	2.74018597
70	sphingoid metabolic process (GO:0046519)	2.73408219
71	recombinational repair (GO:0000725)	2.72453906
72	cellular response to sterol (GO:0036315)	2.72424667
73	activated T cell proliferation (GO:0050798)	2.71962009
74	synapsis (GO:0007129)	2.70612814
75	double-strand break repair via homologous recombination (GO:0000724)	2.69135238
76	regulation of appetite (GO:0032098)	2.69022166
77	NAD biosynthetic process (GO:0009435)	2.67984246
78	regulation of action potential (GO:0098900)	2.67841700
79	photoreceptor cell development (GO:0042461)	2.67202869
80	axoneme assembly (GO:0035082)	2.66201140
81	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.64637830
82	monoubiquitinated protein deubiquitination (GO:0035520)	2.64246743
83	adaptation of signaling pathway (GO:0023058)	2.63557291
84	aspartate family amino acid catabolic process (GO:0009068)	2.63542555
85	aromatic amino acid family metabolic process (GO:0009072)	2.60537083
86	primary amino compound metabolic process (GO:1901160)	2.59973883
87	benzene-containing compound metabolic process (GO:0042537)	2.59675040
88	interferon-gamma production (GO:0032609)	2.58742336
89	prenylation (GO:0097354)	2.58436557
90	protein prenylation (GO:0018342)	2.58436557
91	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.58076875
92	peptidyl-histidine modification (GO:0018202)	2.58018050
93	proline transport (GO:0015824)	2.56826731
94	cilium organization (GO:0044782)	2.55491273
95	thyroid hormone generation (GO:0006590)	2.53390700
96	protein K6-linked ubiquitination (GO:0085020)	2.52602988
97	cilium assembly (GO:0042384)	2.52279948
98	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.50091978
99	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.49622889
100	regulation of hexokinase activity (GO:1903299)	2.49277695

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.03970887
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.39865848
3	VDR_22108803_ChIP-Seq_LS180_Human	3.10601283
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00046439
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.91135084
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.81555498
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.79146609
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76268070
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.53563599
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.49834668
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.43016182
12	P300_19829295_ChIP-Seq_ESCs_Human	2.28021352
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.21768031
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15375452
15	EWS_26573619_Chip-Seq_HEK293_Human	2.12479102
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.08322384
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.05821873
18	FUS_26573619_Chip-Seq_HEK293_Human	2.05297751
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04891500
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.95394804
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.91243033
22	STAT3_23295773_ChIP-Seq_U87_Human	1.88768707
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.80916739
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.80572119
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.76301685
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.76255885
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.73541175
28	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.71959566
29	TCF4_23295773_ChIP-Seq_U87_Human	1.71659350
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71222643
31	AR_25329375_ChIP-Seq_VCAP_Human	1.70848012
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.68485517
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68485517
34	AR_21572438_ChIP-Seq_LNCaP_Human	1.63816237
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.63130959
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.58211000
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.55413314
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53237848
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51764400
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50359538
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47462133
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.46863828
43	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.43445270
44	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.43065268
45	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39895513
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.38299518
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37425784
48	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.36274430
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35150593
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34865375
51	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.34790141
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34307842
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.33002546
54	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.32172377
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.31525259
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30800867
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30684882
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30060820
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29629251
60	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.28705029
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.27464392
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.25853389
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25484568
64	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.24593159
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24395418
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22939008
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22186386
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22186386
69	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.20237447
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20143915
71	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20143915
72	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18680482
73	TP53_16413492_ChIP-PET_HCT116_Human	1.16817234
74	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.16435439
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14634207
76	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.11839341
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11686876
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11483506
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11290411
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11290411
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10390535
82	DROSHA_22980978_ChIP-Seq_HELA_Human	1.09684125
83	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.08255647
84	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06965290
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06869396
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.06556590
87	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.06479946
88	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05849468
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05593923
90	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03524146
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03029512
92	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02941948
93	JUN_21703547_ChIP-Seq_K562_Human	1.01464996
94	NCOR_22424771_ChIP-Seq_293T_Human	1.00354841
95	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.00157547
96	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99567691
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99078128
98	TBL1_22424771_ChIP-Seq_293T_Human	0.99024417
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97257917
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.97044867

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.77172321
2	MP0003195_calcinosis	3.30440774
3	MP0008057_abnormal_DNA_replication	3.00407180
4	MP0005551_abnormal_eye_electrophysiolog	2.64374717
5	MP0002837_dystrophic_cardiac_calcinosis	2.56696744
6	MP0002736_abnormal_nociception_after	2.49368205
7	MP0008877_abnormal_DNA_methylation	2.48888244
8	MP0001968_abnormal_touch/_nociception	2.47902876
9	MP0002102_abnormal_ear_morphology	2.42829884
10	MP0009046_muscle_twitch	2.32913403
11	MP0004043_abnormal_pH_regulation	2.23332529
12	MP0002138_abnormal_hepatobiliary_system	2.22890351
13	MP0003183_abnormal_peptide_metabolism	2.16899686
14	MP0000372_irregular_coat_pigmentation	2.16375205
15	MP0001501_abnormal_sleep_pattern	2.15366168
16	MP0003646_muscle_fatigue	2.06873720
17	MP0005171_absent_coat_pigmentation	2.04721919
18	MP0006276_abnormal_autonomic_nervous	1.97875603
19	MP0000427_abnormal_hair_cycle	1.96214797
20	MP0005253_abnormal_eye_physiology	1.94976426
21	MP0005670_abnormal_white_adipose	1.93003454
22	MP0005310_abnormal_salivary_gland	1.92840575
23	MP0001984_abnormal_olfaction	1.92056158
24	MP0005646_abnormal_pituitary_gland	1.90640814
25	MP0009745_abnormal_behavioral_response	1.89133235
26	MP0001486_abnormal_startle_reflex	1.84257241
27	MP0003880_abnormal_central_pattern	1.78388427
28	MP0004147_increased_porphyrin_level	1.71916898
29	MP0003136_yellow_coat_color	1.68373574
30	MP0002272_abnormal_nervous_system	1.62953607
31	MP0002938_white_spotting	1.58566308
32	MP0002876_abnormal_thyroid_physiology	1.56488247
33	MP0002234_abnormal_pharynx_morphology	1.55881098
34	MP0003787_abnormal_imprinting	1.47626160
35	MP0005174_abnormal_tail_pigmentation	1.46760895
36	MP0001986_abnormal_taste_sensitivity	1.46586699
37	MP0006292_abnormal_olfactory_placode	1.46361890
38	MP0002064_seizures	1.39484152
39	MP0000383_abnormal_hair_follicle	1.36935847
40	MP0010386_abnormal_urinary_bladder	1.36837056
41	MP0008872_abnormal_physiological_respon	1.34860052
42	MP0008875_abnormal_xenobiotic_pharmacok	1.31590601
43	MP0002163_abnormal_gland_morphology	1.31312226
44	MP0005647_abnormal_sex_gland	1.31081130
45	MP0001970_abnormal_pain_threshold	1.28740590
46	MP0002254_reproductive_system_inflammat	1.26079673
47	MP0000631_abnormal_neuroendocrine_gland	1.23428669
48	MP0006072_abnormal_retinal_apoptosis	1.21510609
49	MP0002735_abnormal_chemical_nociception	1.21340926
50	MP0003252_abnormal_bile_duct	1.19990049
51	MP0001485_abnormal_pinna_reflex	1.17871647
52	MP0002572_abnormal_emotion/affect_behav	1.16407256
53	MP0004924_abnormal_behavior	1.14109046
54	MP0005386_behavior/neurological_phenoty	1.14109046
55	MP0003718_maternal_effect	1.11358477
56	MP0001764_abnormal_homeostasis	1.11131729
57	MP0005645_abnormal_hypothalamus_physiol	1.08307118
58	MP0000371_diluted_coat_color	1.07301305
59	MP0002095_abnormal_skin_pigmentation	1.05612799
60	MP0004142_abnormal_muscle_tone	1.05473215
61	MP0008058_abnormal_DNA_repair	1.05284594
62	MP0002733_abnormal_thermal_nociception	1.04275305
63	MP0005085_abnormal_gallbladder_physiolo	1.04168130
64	MP0002653_abnormal_ependyma_morphology	1.02310215
65	MP0005075_abnormal_melanosome_morpholog	1.01745689
66	MP0002067_abnormal_sensory_capabilities	1.01100955
67	MP0005379_endocrine/exocrine_gland_phen	0.99409354
68	MP0009697_abnormal_copulation	0.98760904
69	MP0005084_abnormal_gallbladder_morpholo	0.98667666
70	MP0004215_abnormal_myocardial_fiber	0.94104376
71	MP0002229_neurodegeneration	0.93145713
72	MP0005389_reproductive_system_phenotype	0.92967113
73	MP0003635_abnormal_synaptic_transmissio	0.91538602
74	MP0003698_abnormal_male_reproductive	0.90646540
75	MP0001529_abnormal_vocalization	0.88864846
76	MP0002928_abnormal_bile_duct	0.88581539
77	MP0002090_abnormal_vision	0.88324768
78	MP0002638_abnormal_pupillary_reflex	0.88265928
79	MP0005410_abnormal_fertilization	0.87194725
80	MP0000230_abnormal_systemic_arterial	0.85300198
81	MP0002557_abnormal_social/conspecific_i	0.85123957
82	MP0001919_abnormal_reproductive_system	0.83915834
83	MP0000015_abnormal_ear_pigmentation	0.82957365
84	MP0003045_fibrosis	0.82378007
85	MP0002139_abnormal_hepatobiliary_system	0.82176835
86	MP0002751_abnormal_autonomic_nervous	0.81783806
87	MP0002063_abnormal_learning/memory/cond	0.81254925
88	MP0005408_hypopigmentation	0.80950505
89	MP0004742_abnormal_vestibular_system	0.80823838
90	MP0003806_abnormal_nucleotide_metabolis	0.80454011
91	MP0005266_abnormal_metabolism	0.80075202
92	MP0001324_abnormal_eye_pigmentation	0.79998768
93	MP0005195_abnormal_posterior_eye	0.78967460
94	MP0005167_abnormal_blood-brain_barrier	0.77612681
95	MP0003137_abnormal_impulse_conducting	0.75991803
96	MP0001929_abnormal_gametogenesis	0.73849275
97	MP0001963_abnormal_hearing_physiology	0.73320281
98	MP0002734_abnormal_mechanical_nocicepti	0.73090211
99	MP0002752_abnormal_somatic_nervous	0.73049442
100	MP0005395_other_phenotype	0.72331216

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.75035616
2	Pancreatic cysts (HP:0001737)	4.71146091
3	True hermaphroditism (HP:0010459)	4.24825445
4	Pancreatic fibrosis (HP:0100732)	4.20020301
5	Congenital stationary night blindness (HP:0007642)	3.80836435
6	Gaze-evoked nystagmus (HP:0000640)	3.75405782
7	Attenuation of retinal blood vessels (HP:0007843)	3.72125231
8	Abnormality of midbrain morphology (HP:0002418)	3.45627756
9	Molar tooth sign on MRI (HP:0002419)	3.45627756
10	Absent speech (HP:0001344)	3.35961091
11	Congenital sensorineural hearing impairment (HP:0008527)	3.32716598
12	Genetic anticipation (HP:0003743)	3.28181347
13	Chronic hepatic failure (HP:0100626)	3.25382848
14	Progressive cerebellar ataxia (HP:0002073)	3.17789542
15	Abolished electroretinogram (ERG) (HP:0000550)	3.11301978
16	Nephronophthisis (HP:0000090)	3.10592807
17	Cystic liver disease (HP:0006706)	2.93633193
18	Bony spicule pigmentary retinopathy (HP:0007737)	2.92030397
19	Abnormality of the renal medulla (HP:0100957)	2.89398438
20	Abnormality of the renal cortex (HP:0011035)	2.88984338
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.82645591
22	Medial flaring of the eyebrow (HP:0010747)	2.77712426
23	Intestinal atresia (HP:0011100)	2.71002647
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.66627420
25	Decreased central vision (HP:0007663)	2.64374580
26	Pendular nystagmus (HP:0012043)	2.45878368
27	Fair hair (HP:0002286)	2.43282067
28	Febrile seizures (HP:0002373)	2.42809588
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.41957759
30	Cerebellar dysplasia (HP:0007033)	2.40035574
31	Sclerocornea (HP:0000647)	2.34552357
32	Focal motor seizures (HP:0011153)	2.30315185
33	Gait imbalance (HP:0002141)	2.29582796
34	Clumsiness (HP:0002312)	2.28972047
35	Congenital primary aphakia (HP:0007707)	2.28267902
36	Male pseudohermaphroditism (HP:0000037)	2.28135404
37	Large for gestational age (HP:0001520)	2.27348683
38	Abnormal drinking behavior (HP:0030082)	2.27020422
39	Polydipsia (HP:0001959)	2.27020422
40	Protruding tongue (HP:0010808)	2.26469408
41	Congenital hepatic fibrosis (HP:0002612)	2.25505702
42	Focal seizures (HP:0007359)	2.18423083
43	Genital tract atresia (HP:0001827)	2.18346324
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18234080
45	Type II lissencephaly (HP:0007260)	2.17869267
46	Progressive inability to walk (HP:0002505)	2.14253264
47	Furrowed tongue (HP:0000221)	2.14036695
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.13977984
49	Postaxial foot polydactyly (HP:0001830)	2.12302589
50	Widely spaced teeth (HP:0000687)	2.12039128
51	Dialeptic seizures (HP:0011146)	2.11648737
52	Retinitis pigmentosa (HP:0000510)	2.10999235
53	Anencephaly (HP:0002323)	2.08513499
54	Keratoconus (HP:0000563)	2.07659618
55	Increased corneal curvature (HP:0100692)	2.07659618
56	Bile duct proliferation (HP:0001408)	2.06216385
57	Abnormal biliary tract physiology (HP:0012439)	2.06216385
58	Ketoacidosis (HP:0001993)	2.04875569
59	Decreased circulating renin level (HP:0003351)	2.01130228
60	Inability to walk (HP:0002540)	2.00364077
61	Astigmatism (HP:0000483)	2.00069978
62	Hyperglycinuria (HP:0003108)	1.99472297
63	Vaginal atresia (HP:0000148)	1.99216218
64	Nephrogenic diabetes insipidus (HP:0009806)	1.98871163
65	Small hand (HP:0200055)	1.98110887
66	Generalized hypopigmentation of hair (HP:0011358)	1.97012025
67	Broad-based gait (HP:0002136)	1.92145029
68	Constricted visual fields (HP:0001133)	1.91930351
69	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.91156143
70	Abnormality of alanine metabolism (HP:0010916)	1.89799038
71	Hyperalaninemia (HP:0003348)	1.89799038
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.89799038
73	Amelogenesis imperfecta (HP:0000705)	1.89531257
74	Methylmalonic aciduria (HP:0012120)	1.89429338
75	Tubular atrophy (HP:0000092)	1.88845305
76	Tented upper lip vermilion (HP:0010804)	1.87310462
77	Preaxial hand polydactyly (HP:0001177)	1.87049678
78	Drooling (HP:0002307)	1.85711903
79	Short foot (HP:0001773)	1.85391801
80	Occipital encephalocele (HP:0002085)	1.85179917
81	Abnormality of macular pigmentation (HP:0008002)	1.83355851
82	Polyuria (HP:0000103)	1.83229793
83	Volvulus (HP:0002580)	1.83218406
84	Central scotoma (HP:0000603)	1.81317475
85	Thyroid-stimulating hormone excess (HP:0002925)	1.80964349
86	Stomach cancer (HP:0012126)	1.80752479
87	Retinal dysplasia (HP:0007973)	1.77833414
88	Facial diplegia (HP:0001349)	1.75929899
89	3-Methylglutaconic aciduria (HP:0003535)	1.73101512
90	Poikiloderma (HP:0001029)	1.73062928
91	Severe visual impairment (HP:0001141)	1.72441456
92	Optic nerve hypoplasia (HP:0000609)	1.72044247
93	Sloping forehead (HP:0000340)	1.69818352
94	Absent/shortened dynein arms (HP:0200106)	1.68517471
95	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.68517471
96	Chorioretinal atrophy (HP:0000533)	1.68395510
97	Poor coordination (HP:0002370)	1.68351283
98	Ketosis (HP:0001946)	1.67286561
99	Delayed puberty (HP:0000823)	1.66817738
100	Dandy-Walker malformation (HP:0001305)	1.64438841

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.98265319
2	WNK3	3.37215123
3	ADRBK2	2.59027603
4	MAP4K2	2.58942568
5	BMPR1B	2.37637036
6	ACVR1B	2.23401221
7	PINK1	2.12715737
8	MAPK13	2.07621495
9	ZAK	1.94187526
10	TRIM28	1.91801223
11	INSRR	1.88758386
12	BCR	1.85953368
13	CASK	1.79195791
14	GRK1	1.77293980
15	STK38L	1.77191931
16	NTRK3	1.69797371
17	FER	1.59345429
18	OXSR1	1.59319517
19	NUAK1	1.42086274
20	MAP3K4	1.40025242
21	PRKD3	1.39592063
22	MKNK2	1.35342182
23	TXK	1.30241342
24	TAOK3	1.28513255
25	LATS1	1.22489972
26	MARK1	1.22009376
27	ERBB3	1.16266991
28	STK39	1.16208511
29	STK3	1.09495528
30	EIF2AK3	1.08050568
31	PAK3	1.06262239
32	EPHA4	1.00852745
33	BRSK2	1.00535458
34	PRKCE	0.96677135
35	ADRBK1	0.96365424
36	PTK2B	0.93204088
37	TNIK	0.87767284
38	PDK2	0.87135837
39	AKT3	0.82899514
40	TEC	0.79969549
41	WNK4	0.75158585
42	MKNK1	0.73553886
43	CSNK1A1L	0.73001719
44	CSNK1G1	0.69570605
45	PLK2	0.67698474
46	MARK3	0.67275355
47	PLK4	0.67205902
48	TGFBR1	0.65078397
49	CSNK1G3	0.64830141
50	PIK3CA	0.64757321
51	IRAK1	0.64581874
52	CSNK1G2	0.63995183
53	YES1	0.63289584
54	TNK2	0.63035865
55	MST4	0.59233099
56	PLK3	0.58505302
57	PRKCG	0.55764785
58	DAPK2	0.54451949
59	FGFR2	0.54076331
60	MAP2K7	0.49936904
61	PIK3CG	0.49602586
62	PRKCZ	0.49201855
63	DYRK2	0.47493555
64	CAMK2A	0.47341626
65	GRK5	0.47256607
66	WEE1	0.46337174
67	PKN1	0.44021048
68	SGK2	0.41875477
69	PRKAA2	0.41443516
70	MAPKAPK5	0.41270759
71	STK38	0.40741144
72	CSNK1A1	0.39638666
73	CDK3	0.39240051
74	TRPM7	0.39148869
75	CSNK1D	0.38662790
76	CHEK2	0.38595143
77	PRKACA	0.37462190
78	PRKG1	0.37440705
79	TAF1	0.36943748
80	MAPKAPK3	0.35667368
81	EIF2AK2	0.35475937
82	CDK19	0.35171207
83	MAP3K7	0.34263016
84	CCNB1	0.33676010
85	PRKCH	0.33292336
86	CAMKK2	0.32199896
87	DYRK3	0.32073841
88	OBSCN	0.31767434
89	FLT3	0.30282609
90	BCKDK	0.29428163
91	BLK	0.29192521
92	IKBKB	0.28773521
93	VRK1	0.28690687
94	NEK6	0.28405796
95	ATR	0.27815275
96	ATM	0.26988231
97	RPS6KA5	0.26449905
98	PRKCB	0.26282244
99	GRK7	0.26135754
100	ABL1	0.25774564

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.18714364
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.04845869
3	Phototransduction_Homo sapiens_hsa04744	2.80068327
4	Propanoate metabolism_Homo sapiens_hsa00640	2.61636708
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.35887899
6	Nicotine addiction_Homo sapiens_hsa05033	2.24064105
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.16171166
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.15413872
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.15032689
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.12122311
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.09758276
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.05706674
13	Tryptophan metabolism_Homo sapiens_hsa00380	2.05191192
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.04643200
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.91726213
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.90449220
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.87271655
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79575271
19	Homologous recombination_Homo sapiens_hsa03440	1.77282925
20	ABC transporters_Homo sapiens_hsa02010	1.70254942
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69921333
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.67597563
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.66060514
24	Taste transduction_Homo sapiens_hsa04742	1.62884721
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53490551
26	Olfactory transduction_Homo sapiens_hsa04740	1.48762604
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.48482651
28	Morphine addiction_Homo sapiens_hsa05032	1.40799843
29	Glycerolipid metabolism_Homo sapiens_hsa00561	1.38377526
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.36470208
31	Histidine metabolism_Homo sapiens_hsa00340	1.32847949
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.29593587
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19037058
34	Serotonergic synapse_Homo sapiens_hsa04726	1.17975235
35	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.13600399
36	Salivary secretion_Homo sapiens_hsa04970	1.13306571
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.12595592
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12525943
39	GABAergic synapse_Homo sapiens_hsa04727	1.09454126
40	RNA polymerase_Homo sapiens_hsa03020	1.08846207
41	Peroxisome_Homo sapiens_hsa04146	1.08160465
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.07980663
43	Fatty acid metabolism_Homo sapiens_hsa01212	1.07404405
44	Calcium signaling pathway_Homo sapiens_hsa04020	1.07149990
45	Fat digestion and absorption_Homo sapiens_hsa04975	1.06223280
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05394631
47	Retinol metabolism_Homo sapiens_hsa00830	1.05069295
48	Fatty acid degradation_Homo sapiens_hsa00071	1.03804689
49	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.01195316
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99859492
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.99576278
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.98655499
53	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.95728928
54	Circadian entrainment_Homo sapiens_hsa04713	0.92602850
55	Basal transcription factors_Homo sapiens_hsa03022	0.92044367
56	Caffeine metabolism_Homo sapiens_hsa00232	0.88003751
57	Insulin secretion_Homo sapiens_hsa04911	0.84868145
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84643715
59	Lysine degradation_Homo sapiens_hsa00310	0.84636623
60	Pancreatic secretion_Homo sapiens_hsa04972	0.80615529
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76460065
62	Protein export_Homo sapiens_hsa03060	0.74179704
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73392207
64	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73212172
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.70707041
66	Fatty acid elongation_Homo sapiens_hsa00062	0.68852504
67	One carbon pool by folate_Homo sapiens_hsa00670	0.67985705
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62460832
69	Metabolic pathways_Homo sapiens_hsa01100	0.60573478
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.60301332
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.60014847
72	RNA degradation_Homo sapiens_hsa03018	0.59806263
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57714982
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56011715
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55749928
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.55621971
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.54940024
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54108246
79	Purine metabolism_Homo sapiens_hsa00230	0.53581793
80	Cholinergic synapse_Homo sapiens_hsa04725	0.52477774
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51120702
82	Regulation of autophagy_Homo sapiens_hsa04140	0.49626583
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.48706851
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47300322
85	Glutathione metabolism_Homo sapiens_hsa00480	0.46309368
86	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45129141
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44996581
88	Long-term depression_Homo sapiens_hsa04730	0.44335895
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39942633
90	Proteasome_Homo sapiens_hsa03050	0.39915103
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39151330
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37759817
93	Gastric acid secretion_Homo sapiens_hsa04971	0.35825084
94	Circadian rhythm_Homo sapiens_hsa04710	0.30629772
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.28733021
96	Renin secretion_Homo sapiens_hsa04924	0.27464541
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.26775825
98	Cocaine addiction_Homo sapiens_hsa05030	0.24745017
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.24491578
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.24288518

SUCLG2P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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