ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	7.87763118
2	behavioral response to nicotine (GO:0035095)	7.24786167
3	dendritic spine morphogenesis (GO:0060997)	7.20263744
4	nucleobase catabolic process (GO:0046113)	6.50401532
5	mitochondrion transport along microtubule (GO:0047497)	5.62446896
6	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	5.62446896
7	axonal fasciculation (GO:0007413)	5.50426755
8	establishment of mitochondrion localization (GO:0051654)	5.37069370
9	cell migration in hindbrain (GO:0021535)	5.30218471
10	positive regulation of dendritic spine morphogenesis (GO:0061003)	5.22827530
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.96168464
12	neuron recognition (GO:0008038)	4.95739600
13	positive regulation of CREB transcription factor activity (GO:0032793)	4.34279034
14	dendritic spine organization (GO:0097061)	4.32721702
15	chaperone-mediated protein transport (GO:0072321)	4.24318341
16	cerebellar Purkinje cell differentiation (GO:0021702)	4.14765834
17	startle response (GO:0001964)	3.94046268
18	cellular anion homeostasis (GO:0030002)	3.93207458
19	autophagic vacuole fusion (GO:0000046)	3.90178529
20	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.88052041
21	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.85319795
22	neuronal ion channel clustering (GO:0045161)	3.80347463
23	N-glycan processing (GO:0006491)	3.75677297
24	retinal ganglion cell axon guidance (GO:0031290)	3.71687467
25	cranial nerve morphogenesis (GO:0021602)	3.69573376
26	termination of RNA polymerase III transcription (GO:0006386)	3.65584600
27	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.65584600
28	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.60941467
29	regulation of mitotic spindle checkpoint (GO:1903504)	3.60941467
30	layer formation in cerebral cortex (GO:0021819)	3.56608688
31	urogenital system development (GO:0001655)	3.54865150
32	trivalent inorganic anion homeostasis (GO:0072506)	3.47719875
33	phosphate ion homeostasis (GO:0055062)	3.47719875
34	transmission of nerve impulse (GO:0019226)	3.46013539
35	neuron remodeling (GO:0016322)	3.43886731
36	auditory behavior (GO:0031223)	3.40731123
37	GTP biosynthetic process (GO:0006183)	3.40273151
38	protein polyglutamylation (GO:0018095)	3.34467026
39	synaptic transmission, cholinergic (GO:0007271)	3.30237925
40	positive regulation of cell cycle checkpoint (GO:1901978)	3.24615426
41	UTP biosynthetic process (GO:0006228)	3.16464810
42	cerebral cortex radially oriented cell migration (GO:0021799)	3.14513617
43	collecting duct development (GO:0072044)	3.13902955
44	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.13420926
45	neuromuscular process controlling posture (GO:0050884)	3.12966030
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.10756044
47	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.10356901
48	UTP metabolic process (GO:0046051)	3.06575613
49	synaptic transmission, glutamatergic (GO:0035249)	3.04893906
50	synaptic vesicle endocytosis (GO:0048488)	3.03323424
51	negative regulation of neurotransmitter secretion (GO:0046929)	3.02759663
52	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.02404275
53	dendrite morphogenesis (GO:0048813)	3.01962278
54	regulation of microtubule-based movement (GO:0060632)	3.00715205
55	positive regulation of mitochondrial fission (GO:0090141)	2.94698185
56	cellular response to cholesterol (GO:0071397)	2.94478750
57	postsynaptic membrane organization (GO:0001941)	2.93465718
58	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.92914694
59	ATP synthesis coupled proton transport (GO:0015986)	2.92914694
60	epithelial cilium movement (GO:0003351)	2.92855708
61	cellular ketone body metabolic process (GO:0046950)	2.89249827
62	artery development (GO:0060840)	2.88087719
63	camera-type eye morphogenesis (GO:0048593)	2.84652858
64	central nervous system projection neuron axonogenesis (GO:0021952)	2.84571424
65	potassium ion homeostasis (GO:0055075)	2.84025611
66	glycosphingolipid biosynthetic process (GO:0006688)	2.82743444
67	attachment of spindle microtubules to kinetochore (GO:0008608)	2.81732654
68	cell proliferation in forebrain (GO:0021846)	2.80386478
69	negative regulation of macroautophagy (GO:0016242)	2.78188815
70	organelle membrane fusion (GO:0090174)	2.77266363
71	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.76208241
72	membrane depolarization during action potential (GO:0086010)	2.74287361
73	cytokine biosynthetic process (GO:0042089)	2.73952795
74	somite development (GO:0061053)	2.73089192
75	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.72348708
76	positive regulation of dendritic spine development (GO:0060999)	2.69295568
77	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.67502596
78	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.67465281
79	behavioral response to ethanol (GO:0048149)	2.66890017
80	positive regulation of synapse assembly (GO:0051965)	2.65447388
81	regulation of action potential (GO:0098900)	2.65390214
82	magnesium ion transport (GO:0015693)	2.65034384
83	neuron cell-cell adhesion (GO:0007158)	2.64299529
84	arginine catabolic process (GO:0006527)	2.63923100
85	prenylation (GO:0097354)	2.63549973
86	protein prenylation (GO:0018342)	2.63549973
87	retina layer formation (GO:0010842)	2.58893910
88	mechanosensory behavior (GO:0007638)	2.58251810
89	presynaptic membrane organization (GO:0097090)	2.56778846
90	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.56439959
91	axon extension (GO:0048675)	2.55741720
92	ketone body metabolic process (GO:1902224)	2.53515933
93	atrial cardiac muscle cell action potential (GO:0086014)	2.53043196
94	sialylation (GO:0097503)	2.52079704
95	substrate-independent telencephalic tangential migration (GO:0021826)	2.51153989
96	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.51153989
97	cellular response to sterol (GO:0036315)	2.50084701
98	neuromuscular synaptic transmission (GO:0007274)	2.49638708
99	positive regulation of dendrite morphogenesis (GO:0050775)	2.48912938
100	negative regulation of catenin import into nucleus (GO:0035414)	2.47903322

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.57050252
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.22241157
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.98568233
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.63893652
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.63842588
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.54197811
7	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	2.48078180
8	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.44950163
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.35356628
10	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.32966756
11	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.32543261
12	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.24386467
13	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.20686028
14	REST_21632747_ChIP-Seq_MESCs_Mouse	2.14935300
15	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.12119380
16	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.10415260
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.07254281
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.04473317
19	DROSHA_22980978_ChIP-Seq_HELA_Human	2.02402254
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.01260260
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.01132942
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.95250455
23	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.91659647
24	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.88423571
25	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.87245353
26	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.83972369
27	VDR_22108803_ChIP-Seq_LS180_Human	1.80040967
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.79188117
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.71660993
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.70439378
31	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.69126117
32	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.64131414
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.63156135
34	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.63156135
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61315335
36	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.60655002
37	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.53732361
38	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52908915
39	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.52804436
40	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.50456842
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46750125
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.46563839
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41970720
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.39470469
45	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.36873899
46	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.36248533
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31777386
48	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.31555065
49	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.26771390
50	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.25395558
51	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.24931644
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21412798
53	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21312958
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21312958
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19454295
56	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.17386649
57	FUS_26573619_Chip-Seq_HEK293_Human	1.17089076
58	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16768729
59	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16627864
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14073605
61	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.13047516
62	CTCF_27219007_Chip-Seq_Bcells_Human	1.12259834
63	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.09954033
64	SMAD4_21799915_ChIP-Seq_A2780_Human	1.08376316
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06472709
66	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01791417
67	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00915238
68	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98155195
69	P300_19829295_ChIP-Seq_ESCs_Human	0.96731004
70	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.94971448
71	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.94608464
72	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.94550958
73	BCAT_22108803_ChIP-Seq_LS180_Human	0.93662699
74	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.92005623
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90724811
76	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89832770
77	ER_23166858_ChIP-Seq_MCF-7_Human	0.89410034
78	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89350766
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89140583
80	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.89078724
81	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88546841
82	TAF2_19829295_ChIP-Seq_ESCs_Human	0.88543615
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.88312251
84	AR_25329375_ChIP-Seq_VCAP_Human	0.88052668
85	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87879748
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.85150217
87	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.85149488
88	EWS_26573619_Chip-Seq_HEK293_Human	0.85038544
89	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.84579209
90	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.83334616
91	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.82991200
92	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.82252400
93	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.81957460
94	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.81951207
95	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.80791577
96	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.79527773
97	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.79336252
98	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.78027092
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.78009497
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.77643043

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	4.46053410
2	MP0004859_abnormal_synaptic_plasticity	4.15694825
3	MP0003880_abnormal_central_pattern	3.38029589
4	MP0005083_abnormal_biliary_tract	2.92049439
5	MP0009379_abnormal_foot_pigmentation	2.86160069
6	MP0000778_abnormal_nervous_system	2.69336736
7	MP0005645_abnormal_hypothalamus_physiol	2.57992714
8	MP0004142_abnormal_muscle_tone	2.55933771
9	MP0002735_abnormal_chemical_nociception	2.52124661
10	MP0003635_abnormal_synaptic_transmissio	2.41294743
11	MP0006276_abnormal_autonomic_nervous	2.31502955
12	MP0006292_abnormal_olfactory_placode	2.28454170
13	MP0008995_early_reproductive_senescence	2.22734294
14	MP0002063_abnormal_learning/memory/cond	2.16868352
15	MP0009745_abnormal_behavioral_response	2.12702601
16	MP0004742_abnormal_vestibular_system	2.10386074
17	MP0002733_abnormal_thermal_nociception	2.07449440
18	MP0002184_abnormal_innervation	1.98249799
19	MP0003646_muscle_fatigue	1.82752765
20	MP0001970_abnormal_pain_threshold	1.81444033
21	MP0005084_abnormal_gallbladder_morpholo	1.80986923
22	MP0010030_abnormal_orbit_morphology	1.79803737
23	MP0003136_yellow_coat_color	1.78057348
24	MP0002272_abnormal_nervous_system	1.72583180
25	MP0002572_abnormal_emotion/affect_behav	1.72527222
26	MP0002064_seizures	1.71529255
27	MP0008789_abnormal_olfactory_epithelium	1.70392315
28	MP0002734_abnormal_mechanical_nocicepti	1.66884915
29	MP0002160_abnormal_reproductive_system	1.63263864
30	MP0003195_calcinosis	1.62073109
31	MP0005499_abnormal_olfactory_system	1.61679008
32	MP0005394_taste/olfaction_phenotype	1.61679008
33	MP0000955_abnormal_spinal_cord	1.60230165
34	MP0002638_abnormal_pupillary_reflex	1.57549689
35	MP0001968_abnormal_touch/_nociception	1.56339496
36	MP0004270_analgesia	1.53991328
37	MP0004133_heterotaxia	1.53836202
38	MP0010386_abnormal_urinary_bladder	1.53644915
39	MP0002557_abnormal_social/conspecific_i	1.52629968
40	MP0003011_delayed_dark_adaptation	1.52153535
41	MP0003122_maternal_imprinting	1.51998573
42	MP0002909_abnormal_adrenal_gland	1.51586750
43	MP0002938_white_spotting	1.48289948
44	MP0003787_abnormal_imprinting	1.43488317
45	MP0009046_muscle_twitch	1.42745588
46	MP0001905_abnormal_dopamine_level	1.39145171
47	MP0005551_abnormal_eye_electrophysiolog	1.38864307
48	MP0002822_catalepsy	1.37321065
49	MP0005389_reproductive_system_phenotype	1.36941286
50	MP0002067_abnormal_sensory_capabilities	1.36844659
51	MP0001919_abnormal_reproductive_system	1.35940744
52	MP0008877_abnormal_DNA_methylation	1.33945477
53	MP0000537_abnormal_urethra_morphology	1.33912104
54	MP0003315_abnormal_perineum_morphology	1.30070328
55	MP0002882_abnormal_neuron_morphology	1.29726464
56	MP0001440_abnormal_grooming_behavior	1.26254816
57	MP0002736_abnormal_nociception_after	1.25364666
58	MP0001486_abnormal_startle_reflex	1.24082631
59	MP0008872_abnormal_physiological_respon	1.23593756
60	MP0003121_genomic_imprinting	1.22117490
61	MP0002837_dystrophic_cardiac_calcinosis	1.18472317
62	MP0000569_abnormal_digit_pigmentation	1.16511720
63	MP0000566_synostosis	1.16479250
64	MP0003283_abnormal_digestive_organ	1.15931214
65	MP0002752_abnormal_somatic_nervous	1.12426448
66	MP0000631_abnormal_neuroendocrine_gland	1.12184555
67	MP0002152_abnormal_brain_morphology	1.10053566
68	MP0004043_abnormal_pH_regulation	1.08254085
69	MP0005451_abnormal_body_composition	1.06662669
70	MP0004811_abnormal_neuron_physiology	1.04883688
71	MP0002229_neurodegeneration	1.03566341
72	MP0008569_lethality_at_weaning	1.02123082
73	MP0000015_abnormal_ear_pigmentation	1.01799902
74	MP0002066_abnormal_motor_capabilities/c	0.98383131
75	MP0000372_irregular_coat_pigmentation	0.98310668
76	MP0003137_abnormal_impulse_conducting	0.95996535
77	MP0005195_abnormal_posterior_eye	0.94972774
78	MP0001293_anophthalmia	0.93018697
79	MP0001663_abnormal_digestive_system	0.92959380
80	MP0002089_abnormal_postnatal_growth/wei	0.90994582
81	MP0001324_abnormal_eye_pigmentation	0.88424955
82	MP0004147_increased_porphyrin_level	0.87980268
83	MP0004924_abnormal_behavior	0.85780200
84	MP0005386_behavior/neurological_phenoty	0.85780200
85	MP0003861_abnormal_nervous_system	0.85326908
86	MP0001986_abnormal_taste_sensitivity	0.84544647
87	MP0000026_abnormal_inner_ear	0.83798681
88	MP0004885_abnormal_endolymph	0.83585709
89	MP0000049_abnormal_middle_ear	0.81751731
90	MP0002095_abnormal_skin_pigmentation	0.80494064
91	MP0005646_abnormal_pituitary_gland	0.79378791
92	MP0001485_abnormal_pinna_reflex	0.77988768
93	MP0003938_abnormal_ear_development	0.77540462
94	MP0001502_abnormal_circadian_rhythm	0.75262354
95	MP0003698_abnormal_male_reproductive	0.74949561
96	MP0003890_abnormal_embryonic-extraembry	0.73922234
97	MP0001542_abnormal_bone_strength	0.73472552
98	MP0002163_abnormal_gland_morphology	0.71499624
99	MP0002210_abnormal_sex_determination	0.70736639
100	MP0004145_abnormal_muscle_electrophysio	0.70479437

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	5.12317492
2	Multiple enchondromatosis (HP:0005701)	4.01155347
3	Retinal dysplasia (HP:0007973)	3.63665363
4	Chronic hepatic failure (HP:0100626)	3.52228338
5	Molar tooth sign on MRI (HP:0002419)	3.50076871
6	Abnormality of midbrain morphology (HP:0002418)	3.50076871
7	Ulnar claw (HP:0001178)	3.30964712
8	Agitation (HP:0000713)	3.26417645
9	Focal seizures (HP:0007359)	3.24995827
10	Short nail (HP:0001799)	3.23146538
11	Concave nail (HP:0001598)	3.13340993
12	Genetic anticipation (HP:0003743)	3.09340440
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.08558772
14	Nephronophthisis (HP:0000090)	3.00994310
15	Ectopic kidney (HP:0000086)	2.99222054
16	Atonic seizures (HP:0010819)	2.95114067
17	Broad-based gait (HP:0002136)	2.93170955
18	Facial cleft (HP:0002006)	2.92646956
19	Pachygyria (HP:0001302)	2.90705040
20	Pancreatic fibrosis (HP:0100732)	2.86558788
21	Radial bowing (HP:0002986)	2.75504244
22	Thyroid-stimulating hormone excess (HP:0002925)	2.75148982
23	Progressive cerebellar ataxia (HP:0002073)	2.67648205
24	Prolonged QT interval (HP:0001657)	2.66654531
25	Pancreatic cysts (HP:0001737)	2.65642824
26	Parakeratosis (HP:0001036)	2.62481123
27	Constricted visual fields (HP:0001133)	2.59699077
28	Polyphagia (HP:0002591)	2.54709620
29	Flat capital femoral epiphysis (HP:0003370)	2.50725780
30	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.49710977
31	Protruding tongue (HP:0010808)	2.48592493
32	Rib fusion (HP:0000902)	2.47096636
33	Broad metatarsal (HP:0001783)	2.45346751
34	Peripheral hypomyelination (HP:0007182)	2.45073407
35	Abnormal number of incisors (HP:0011064)	2.43923561
36	Optic nerve coloboma (HP:0000588)	2.42857221
37	Abnormality of the aortic arch (HP:0012303)	2.39465865
38	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.36940041
39	Dialeptic seizures (HP:0011146)	2.34747639
40	Status epilepticus (HP:0002133)	2.34508978
41	Limb dystonia (HP:0002451)	2.33604015
42	Amblyopia (HP:0000646)	2.33343069
43	Choroideremia (HP:0001139)	2.31808992
44	Mesomelia (HP:0003027)	2.30984618
45	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.29944856
46	Patellar aplasia (HP:0006443)	2.29374581
47	Type II lissencephaly (HP:0007260)	2.25869772
48	Abnormality of the renal medulla (HP:0100957)	2.25592403
49	Abnormality of the labia minora (HP:0012880)	2.24558836
50	Abnormality of the corticospinal tract (HP:0002492)	2.24478633
51	Lissencephaly (HP:0001339)	2.22062828
52	Absence seizures (HP:0002121)	2.21130854
53	Aplasia/Hypoplasia of the patella (HP:0006498)	2.20480593
54	Delayed CNS myelination (HP:0002188)	2.16018833
55	Congenital stationary night blindness (HP:0007642)	2.12141001
56	Gaze-evoked nystagmus (HP:0000640)	2.11814369
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.10389128
58	Infantile muscular hypotonia (HP:0008947)	2.10159842
59	Broad alveolar ridges (HP:0000187)	2.08627343
60	Absent/shortened dynein arms (HP:0200106)	2.05503075
61	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.05503075
62	Hypoplasia of the brainstem (HP:0002365)	2.03799865
63	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.03799865
64	True hermaphroditism (HP:0010459)	2.02539416
65	Inability to walk (HP:0002540)	2.01567682
66	Esotropia (HP:0000565)	1.98583569
67	Abnormality of the 4th metacarpal (HP:0010012)	1.97838090
68	Short 4th metacarpal (HP:0010044)	1.97778261
69	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.97778261
70	Partial agenesis of the corpus callosum (HP:0001338)	1.95459620
71	Short femoral neck (HP:0100864)	1.90106044
72	Osteomalacia (HP:0002749)	1.89417229
73	Drooling (HP:0002307)	1.87228041
74	Hypoplasia of the radius (HP:0002984)	1.86399094
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84566090
76	Abnormal EKG (HP:0003115)	1.84239912
77	Cystic liver disease (HP:0006706)	1.82139403
78	Febrile seizures (HP:0002373)	1.82069714
79	Oligodactyly (hands) (HP:0001180)	1.80924052
80	Impaired smooth pursuit (HP:0007772)	1.80261200
81	Optic nerve hypoplasia (HP:0000609)	1.80027184
82	Epileptiform EEG discharges (HP:0011182)	1.79730320
83	Abolished electroretinogram (ERG) (HP:0000550)	1.79203149
84	Aqueductal stenosis (HP:0002410)	1.78467917
85	Hypsarrhythmia (HP:0002521)	1.77129177
86	Restlessness (HP:0000711)	1.77053079
87	Septo-optic dysplasia (HP:0100842)	1.76531200
88	Anophthalmia (HP:0000528)	1.76416211
89	Slow-growing hair (HP:0002217)	1.76201786
90	Abnormality of hair growth rate (HP:0011363)	1.76201786
91	Thoracic kyphosis (HP:0002942)	1.76134665
92	EEG with generalized epileptiform discharges (HP:0011198)	1.73520316
93	Glossoptosis (HP:0000162)	1.73074561
94	Acute necrotizing encephalopathy (HP:0006965)	1.72697076
95	Anomalous pulmonary venous return (HP:0010772)	1.71796359
96	Visual hallucinations (HP:0002367)	1.71284136
97	Vertebral arch anomaly (HP:0008438)	1.70867253
98	Broad distal phalanx of finger (HP:0009836)	1.70620344
99	Anencephaly (HP:0002323)	1.70036412
100	11 pairs of ribs (HP:0000878)	1.69098394

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHB2	4.66911571
2	CASK	4.50005269
3	MARK1	3.79087862
4	MAP3K12	3.77951020
5	NTRK2	3.31067478
6	PINK1	3.11968809
7	MAP3K11	3.05711789
8	NTRK3	2.43289095
9	DYRK2	2.32984375
10	SIK2	2.19087651
11	PAK3	2.16011612
12	PRKD3	2.11945909
13	MAP2K4	2.03597117
14	CAMK1D	1.97945144
15	PNCK	1.88521069
16	MAPK13	1.76963654
17	WNK3	1.71397507
18	MAP3K4	1.70493364
19	CAMKK1	1.56338264
20	FRK	1.55279150
21	CCNB1	1.52049242
22	MAP2K7	1.49763853
23	CAMKK2	1.47832643
24	ZAK	1.39172163
25	CAMK1G	1.35060466
26	CDC7	1.34247532
27	EPHA4	1.33345113
28	WNK4	1.25745039
29	RPS6KA2	1.22174218
30	PHKG1	1.21882535
31	PHKG2	1.21882535
32	TLK1	1.20338780
33	UHMK1	1.18594289
34	PRKCG	1.15112906
35	INSRR	1.10348313
36	KSR1	1.08724939
37	MINK1	1.06538848
38	ADRBK2	1.05183813
39	CAMK1	1.01179253
40	TNIK	0.96419309
41	NTRK1	0.95278654
42	MAP2K6	0.90720736
43	TYRO3	0.89489129
44	CDK5	0.86609785
45	ERBB2	0.82966759
46	GRK7	0.82372299
47	ABL2	0.79833782
48	MAP3K5	0.76532741
49	ADRBK1	0.71075394
50	DYRK3	0.70341948
51	TXK	0.69151340
52	CDC42BPA	0.67757638
53	CAMK4	0.64864100
54	OXSR1	0.64221394
55	PTK6	0.62598879
56	PKN1	0.62107511
57	RPS6KA1	0.59304965
58	TIE1	0.58827520
59	NME1	0.58230902
60	CSNK1E	0.56727377
61	PAK6	0.56563116
62	GRK1	0.56458752
63	PRKACA	0.56026434
64	SGK1	0.54694375
65	RPS6KA6	0.54185119
66	CDK19	0.53996335
67	PRKG1	0.52602886
68	PRKCZ	0.51407771
69	STK11	0.49333218
70	BRSK1	0.48715524
71	DYRK1A	0.47820372
72	TAOK1	0.46837749
73	TAOK3	0.46813579
74	MAPK15	0.45254290
75	RPS6KA3	0.43718605
76	PIK3CA	0.43363689
77	SGK494	0.43020371
78	SGK223	0.43020371
79	PRKACB	0.41656230
80	TSSK6	0.40185586
81	MARK2	0.39678469
82	MAP3K6	0.39626702
83	AKT1	0.39301414
84	CAMK2A	0.39092314
85	RPS6KL1	0.38656872
86	RPS6KC1	0.38656872
87	PRKACG	0.32543175
88	PRKCQ	0.32392597
89	PRKAA1	0.32125289
90	AURKA	0.30275195
91	WNK1	0.28568026
92	CDK15	0.27430881
93	ATR	0.27350090
94	BCKDK	0.27280422
95	MAPK9	0.26919085
96	FES	0.26805374
97	DMPK	0.26704550
98	FYN	0.26167245
99	NUAK1	0.25217722
100	DYRK1B	0.24958084

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.41150206
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.49790576
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.77080015
4	Parkinsons disease_Homo sapiens_hsa05012	2.45462158
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.42728982
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.16860889
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.04679533
8	Axon guidance_Homo sapiens_hsa04360	1.93434849
9	Ribosome_Homo sapiens_hsa03010	1.93284260
10	RNA polymerase_Homo sapiens_hsa03020	1.92409551
11	Insulin secretion_Homo sapiens_hsa04911	1.88553047
12	Cocaine addiction_Homo sapiens_hsa05030	1.85296380
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.85207281
14	Morphine addiction_Homo sapiens_hsa05032	1.82665044
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.82579060
16	GABAergic synapse_Homo sapiens_hsa04727	1.82560527
17	Regulation of autophagy_Homo sapiens_hsa04140	1.79343942
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.73695776
19	Circadian entrainment_Homo sapiens_hsa04713	1.72048788
20	Alzheimers disease_Homo sapiens_hsa05010	1.69082623
21	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.64883301
22	Homologous recombination_Homo sapiens_hsa03440	1.63008091
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.61370695
24	Butanoate metabolism_Homo sapiens_hsa00650	1.56477868
25	Glutamatergic synapse_Homo sapiens_hsa04724	1.55708783
26	Amphetamine addiction_Homo sapiens_hsa05031	1.52995874
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48085111
28	Taste transduction_Homo sapiens_hsa04742	1.45313859
29	Huntingtons disease_Homo sapiens_hsa05016	1.45114538
30	Cholinergic synapse_Homo sapiens_hsa04725	1.43864035
31	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.41950033
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.37495092
33	Phototransduction_Homo sapiens_hsa04744	1.34342925
34	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.31722939
35	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.28542787
36	Caffeine metabolism_Homo sapiens_hsa00232	1.25579947
37	Sulfur relay system_Homo sapiens_hsa04122	1.20453705
38	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.19701079
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18565476
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.10859394
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10842136
42	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.10158962
43	Dopaminergic synapse_Homo sapiens_hsa04728	1.08493457
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07586746
45	cAMP signaling pathway_Homo sapiens_hsa04024	1.06786957
46	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.04374350
47	Gastric acid secretion_Homo sapiens_hsa04971	0.99271406
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97639324
49	Selenocompound metabolism_Homo sapiens_hsa00450	0.92611375
50	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.90508068
51	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.90244925
52	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.89035428
53	Serotonergic synapse_Homo sapiens_hsa04726	0.88268282
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85902754
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.84470624
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.83381714
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82867914
58	Long-term potentiation_Homo sapiens_hsa04720	0.82597612
59	Alcoholism_Homo sapiens_hsa05034	0.82551591
60	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.81210094
61	Salivary secretion_Homo sapiens_hsa04970	0.78525245
62	Peroxisome_Homo sapiens_hsa04146	0.76421676
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76396187
64	One carbon pool by folate_Homo sapiens_hsa00670	0.74466796
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.70783643
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68430840
67	Olfactory transduction_Homo sapiens_hsa04740	0.67960922
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.67569716
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62991857
70	Purine metabolism_Homo sapiens_hsa00230	0.62583554
71	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.61453814
72	Protein export_Homo sapiens_hsa03060	0.58971433
73	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.58138834
74	Ras signaling pathway_Homo sapiens_hsa04014	0.57944635
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.57680791
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57428631
77	Estrogen signaling pathway_Homo sapiens_hsa04915	0.57344373
78	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.54994727
79	Propanoate metabolism_Homo sapiens_hsa00640	0.54235052
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53534853
81	Renin secretion_Homo sapiens_hsa04924	0.51010006
82	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.50455243
83	Type II diabetes mellitus_Homo sapiens_hsa04930	0.49929713
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49740730
85	Pancreatic secretion_Homo sapiens_hsa04972	0.48954124
86	Retinol metabolism_Homo sapiens_hsa00830	0.47671684
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.46200055
88	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.46034292
89	MAPK signaling pathway_Homo sapiens_hsa04010	0.45502661
90	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.45346357
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.44916789
92	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.43742146
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42623451
94	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.41620180
95	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.41616150
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39031281
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38819749
98	Basal transcription factors_Homo sapiens_hsa03022	0.36553683
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32929150
100	Melanogenesis_Homo sapiens_hsa04916	0.31840700

SUDS3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »