SUFU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.52326342
2lymph vessel development (GO:0001945)4.09432739
3regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.80289926
4cell-cell junction maintenance (GO:0045217)3.75391056
5heterochromatin organization (GO:0070828)3.70481745
6negative regulation of erythrocyte differentiation (GO:0045647)3.66822568
7nucleosome disassembly (GO:0006337)3.54040627
8protein-DNA complex disassembly (GO:0032986)3.54040627
9semaphorin-plexin signaling pathway (GO:0071526)3.52113489
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.49940520
11protein localization to kinetochore (GO:0034501)3.49872603
12mitotic sister chromatid cohesion (GO:0007064)3.43243058
13adherens junction assembly (GO:0034333)3.43040950
143-UTR-mediated mRNA stabilization (GO:0070935)3.42990222
15protein localization to chromosome, centromeric region (GO:0071459)3.40633291
16protein localization to endosome (GO:0036010)3.37234824
17pre-miRNA processing (GO:0031054)3.36137085
18mRNA stabilization (GO:0048255)3.34664192
19RNA stabilization (GO:0043489)3.34664192
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31805148
21stress fiber assembly (GO:0043149)3.31623469
22chromosome condensation (GO:0030261)3.25093191
23negative regulation of RNA splicing (GO:0033119)3.24571479
24mitotic nuclear envelope disassembly (GO:0007077)3.16050464
25cochlea morphogenesis (GO:0090103)3.15588035
26nuclear pore complex assembly (GO:0051292)3.13487740
27negative regulation of histone methylation (GO:0031061)3.12905838
28apoptotic process involved in morphogenesis (GO:0060561)3.12358214
29barbed-end actin filament capping (GO:0051016)3.11036950
30epithelial cell differentiation involved in prostate gland development (GO:0060742)3.10990132
31response to laminar fluid shear stress (GO:0034616)3.07922698
32positive regulation of histone deacetylation (GO:0031065)3.05458900
33regulation of early endosome to late endosome transport (GO:2000641)3.00962095
34endothelial tube morphogenesis (GO:0061154)3.00653394
35morphogenesis of an endothelium (GO:0003159)3.00653394
36regulation of NFAT protein import into nucleus (GO:0051532)2.99969427
37regulation of histone H3-K9 methylation (GO:0051570)2.97643363
38positive regulation of gamma-delta T cell activation (GO:0046645)2.97577703
39focal adhesion assembly (GO:0048041)2.96960687
40cell-substrate adherens junction assembly (GO:0007045)2.96960687
41response to muramyl dipeptide (GO:0032495)2.92562044
42skin morphogenesis (GO:0043589)2.92551166
43basement membrane organization (GO:0071711)2.92460377
44membrane disassembly (GO:0030397)2.91717569
45nuclear envelope disassembly (GO:0051081)2.91717569
46DNA packaging (GO:0006323)2.91601140
47protein retention in ER lumen (GO:0006621)2.91343108
48regulation of mammary gland epithelial cell proliferation (GO:0033599)2.91136446
49nuclear pore organization (GO:0006999)2.90520714
50monoubiquitinated protein deubiquitination (GO:0035520)2.89626038
51DNA duplex unwinding (GO:0032508)2.89198153
52modulation by virus of host morphology or physiology (GO:0019048)2.86314003
53negative regulation of mRNA processing (GO:0050686)2.84562191
54glucocorticoid receptor signaling pathway (GO:0042921)2.84503294
55negative regulation of glial cell proliferation (GO:0060253)2.84496939
56vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.84118707
57sister chromatid segregation (GO:0000819)2.83894807
58DNA geometric change (GO:0032392)2.82938028
59alternative mRNA splicing, via spliceosome (GO:0000380)2.82177764
60regulation of translational fidelity (GO:0006450)2.81141242
61mitotic chromosome condensation (GO:0007076)2.81026000
62negative regulation of homotypic cell-cell adhesion (GO:0034111)2.79178168
63axon extension involved in axon guidance (GO:0048846)2.78958541
64neuron projection extension involved in neuron projection guidance (GO:1902284)2.78958541
65regulation of stem cell maintenance (GO:2000036)2.78563712
66DNA strand elongation involved in DNA replication (GO:0006271)2.76612904
67regulation of gamma-delta T cell differentiation (GO:0045586)2.75776456
68negative regulation of gene expression, epigenetic (GO:0045814)2.75725887
69chromatin assembly (GO:0031497)2.75442449
70DNA conformation change (GO:0071103)2.74932494
71mitotic sister chromatid segregation (GO:0000070)2.73392848
72SMAD protein complex assembly (GO:0007183)2.70980545
73maternal placenta development (GO:0001893)2.70531774
74cell junction maintenance (GO:0034331)2.69045104
75regulation of mRNA stability (GO:0043488)2.68742101
76mannose metabolic process (GO:0006013)2.68509166
77negative regulation of mRNA metabolic process (GO:1903312)2.68059375
78cell migration in hindbrain (GO:0021535)2.67833604
79Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66716540
80dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65269693
81sperm-egg recognition (GO:0035036)2.64690157
82DNA strand elongation (GO:0022616)2.63290116
83cell-substrate junction assembly (GO:0007044)2.62997479
84translesion synthesis (GO:0019985)2.62546826
85regulation of establishment of planar polarity (GO:0090175)2.62498961
86intracellular estrogen receptor signaling pathway (GO:0030520)2.62293891
87DNA replication-dependent nucleosome organization (GO:0034723)2.62119332
88DNA replication-dependent nucleosome assembly (GO:0006335)2.62119332
89cortical actin cytoskeleton organization (GO:0030866)2.62011990
90protein localization to chromosome (GO:0034502)2.61510348
91regulation of sister chromatid cohesion (GO:0007063)2.61455620
92Golgi transport vesicle coating (GO:0048200)2.61372037
93COPI coating of Golgi vesicle (GO:0048205)2.61372037
94dosage compensation (GO:0007549)2.60544130
95binding of sperm to zona pellucida (GO:0007339)2.60237501
96cardiac muscle cell proliferation (GO:0060038)2.60063532
97atrioventricular valve morphogenesis (GO:0003181)2.58404012
98regulation of RNA stability (GO:0043487)2.57096652
99maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57012029
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.55335268
101apoptotic process involved in development (GO:1902742)2.55320675
102modulation by virus of host process (GO:0019054)2.55189795
103NLS-bearing protein import into nucleus (GO:0006607)2.54671954
104chondrocyte proliferation (GO:0035988)2.53966002
105histone H2A acetylation (GO:0043968)2.53771489
106membrane protein ectodomain proteolysis (GO:0006509)2.53744468
107craniofacial suture morphogenesis (GO:0097094)2.53666209
108cell-cell recognition (GO:0009988)2.53254074
109substrate-dependent cell migration (GO:0006929)2.53194067
110cellular extravasation (GO:0045123)2.53149786
111gene silencing by RNA (GO:0031047)2.52851786
112antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52162912
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52162912
114formation of translation preinitiation complex (GO:0001731)2.51275269
115hypotonic response (GO:0006971)2.51100586
116gene silencing (GO:0016458)2.50955660
117negative regulation of chondrocyte differentiation (GO:0032331)2.50674353
118paraxial mesoderm development (GO:0048339)2.50586467
119lens morphogenesis in camera-type eye (GO:0002089)2.49606904
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.49416312
121positive regulation of protein deacetylation (GO:0090312)2.48855607
122vascular endothelial growth factor signaling pathway (GO:0038084)2.48740079
123chromatin silencing (GO:0006342)2.47612218
124cortical cytoskeleton organization (GO:0030865)2.46950692
125positive regulation of extracellular matrix organization (GO:1903055)2.46710937
126negative regulation of stress fiber assembly (GO:0051497)2.46424128
127positive regulation of myotube differentiation (GO:0010831)2.46117486
128cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.45449982
129fusion of sperm to egg plasma membrane (GO:0007342)2.45415519
130cell migration involved in heart development (GO:0060973)2.44616934
131modulation by symbiont of host cellular process (GO:0044068)2.44363331
132DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.44032449
133peptidyl-lysine dimethylation (GO:0018027)2.43993534
134regulation of gamma-delta T cell activation (GO:0046643)2.43341632
135regulation of extracellular matrix disassembly (GO:0010715)2.42954101
136cranial suture morphogenesis (GO:0060363)2.42476093
137amyloid precursor protein catabolic process (GO:0042987)2.42114652
138DNA replication initiation (GO:0006270)2.41692454
139regulation of RNA export from nucleus (GO:0046831)2.40698022
140DNA topological change (GO:0006265)2.40101974
141cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.38902124
142mesodermal cell differentiation (GO:0048333)2.38691359
143Notch signaling involved in heart development (GO:0061314)2.38428201
144antigen processing and presentation of endogenous antigen (GO:0019883)2.38157174
145embryonic process involved in female pregnancy (GO:0060136)2.37491808
146DNA damage response, signal transduction resulting in transcription (GO:0042772)2.37332498
147corticosteroid receptor signaling pathway (GO:0031958)2.36526773
148regulation of spindle organization (GO:0090224)2.36251757
149regulation of chromatin binding (GO:0035561)2.36157638
150chromatin assembly or disassembly (GO:0006333)2.35568054
151positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.34842155
152pinocytosis (GO:0006907)2.34524476
153nuclear envelope organization (GO:0006998)2.33409335
154base-excision repair (GO:0006284)2.32892827
155negative regulation of cell size (GO:0045792)2.32849619
156RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.32514360
157mRNA splicing, via spliceosome (GO:0000398)2.32514360
158endothelial cell chemotaxis (GO:0035767)2.30972598
159negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.30163450
160regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.29913442
161positive regulation of gene expression, epigenetic (GO:0045815)2.29368701
162positive regulation of receptor recycling (GO:0001921)2.29295872
163regulation of leukocyte degranulation (GO:0043300)2.29227714
164striated muscle cell proliferation (GO:0014855)2.28896529
165aorta morphogenesis (GO:0035909)2.28518565
166planar cell polarity pathway involved in neural tube closure (GO:0090179)2.28385994
167regulation of somitogenesis (GO:0014807)2.27467629
168ATP-dependent chromatin remodeling (GO:0043044)2.27113316
169outflow tract septum morphogenesis (GO:0003148)2.26586914
170peptidyl-arginine omega-N-methylation (GO:0035247)2.26581508
171RNA splicing, via transesterification reactions (GO:0000375)2.26391683
172angiogenesis involved in wound healing (GO:0060055)2.25900048
173histone H2A monoubiquitination (GO:0035518)2.25867831
174endochondral ossification (GO:0001958)2.25807591
175replacement ossification (GO:0036075)2.25807591
176positive regulation by organism of defense response of other organism involved in symbiotic interact2.25571842
177modulation by symbiont of host immune response (GO:0052553)2.25571842
178positive regulation by symbiont of host defense response (GO:0052509)2.25571842
179modulation by symbiont of host defense response (GO:0052031)2.25571842
180modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.25571842
181modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.25571842
182bone trabecula formation (GO:0060346)2.25482220
183positive regulation of chromosome segregation (GO:0051984)2.25258914
184cell wall macromolecule catabolic process (GO:0016998)2.25005014
185cell wall macromolecule metabolic process (GO:0044036)2.25005014
186negative regulation of phagocytosis (GO:0050765)2.24500431
187positive regulation of epithelial to mesenchymal transition (GO:0010718)2.24078081
188kidney mesenchyme development (GO:0072074)2.23649477
189positive regulation of blood vessel endothelial cell migration (GO:0043536)2.23455350
190embryonic viscerocranium morphogenesis (GO:0048703)2.23280066
191IMP biosynthetic process (GO:0006188)2.22402628
192positive regulation of SMAD protein import into nucleus (GO:0060391)2.21685072
193spliceosomal tri-snRNP complex assembly (GO:0000244)2.21151352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.78424870
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.61910785
3MYC_22102868_ChIP-Seq_BL_Human4.01333724
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.21199288
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.01488498
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93164057
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.89876728
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75954590
9VDR_21846776_ChIP-Seq_THP-1_Human2.75906860
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66849260
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66441421
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64423324
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.40904025
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.35557385
15TCF7_22412390_ChIP-Seq_EML_Mouse2.31165529
16KDM2B_26808549_Chip-Seq_K562_Human2.20323708
17CIITA_25753668_ChIP-Seq_RAJI_Human2.14219458
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04373316
19* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00545497
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99796582
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.99462641
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.90540432
23* SCL_19346495_ChIP-Seq_HPC-7_Human1.89738491
24* KDM2B_26808549_Chip-Seq_DND41_Human1.88240267
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87028174
26UTX_26944678_Chip-Seq_JUKART_Human1.86059525
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83802258
28MAF_26560356_Chip-Seq_TH1_Human1.79779544
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79257303
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75458487
31AR_21909140_ChIP-Seq_LNCAP_Human1.73532949
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65613372
33XRN2_22483619_ChIP-Seq_HELA_Human1.63253218
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62020906
35VDR_24763502_ChIP-Seq_THP-1_Human1.60839368
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60294099
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.60067135
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57705204
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57647599
40* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57440475
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54700274
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54342850
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53656961
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53186538
45* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51691122
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.45863779
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.45633611
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45029874
49* MYB_26560356_Chip-Seq_TH2_Human1.44761994
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.43485501
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41964122
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40879944
53* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40610791
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40456380
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.39900605
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39297152
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38042912
58MYB_26560356_Chip-Seq_TH1_Human1.37436143
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35242439
60CLOCK_20551151_ChIP-Seq_293T_Human1.33798444
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32486154
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32293970
63* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30946615
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.29475669
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28552026
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27818966
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27067609
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26599469
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26534185
70* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25979792
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.24771554
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24734516
73SMC4_20622854_ChIP-Seq_HELA_Human1.24549915
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.24538002
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22845664
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21765574
77NCOR1_26117541_ChIP-Seq_K562_Human1.21407749
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19995187
79MAF_26560356_Chip-Seq_TH2_Human1.19877207
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.19791220
81* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19236203
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19077539
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18351040
84* GATA1_19941827_ChIP-Seq_MEL_Mouse1.18192502
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.17255160
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.16521405
87CREB1_26743006_Chip-Seq_LNCaP_Human1.16364457
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.15724007
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15211766
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14434573
91LXR_22292898_ChIP-Seq_THP-1_Human1.14376435
92ZNF263_19887448_ChIP-Seq_K562_Human1.13542562
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13011617
94* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12372642
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11691864
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11643789
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.10652567
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10473800
99* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09485254
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09458049
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09443811
102KDM5A_27292631_Chip-Seq_BREAST_Human1.09032310
103* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08788564
104SPI1_23547873_ChIP-Seq_NB4_Human1.08732457
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08401222
106CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04961031
107CTCF_27219007_Chip-Seq_Bcells_Human1.04830550
108SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04407516
109TP63_17297297_ChIP-ChIP_HaCaT_Human1.04159705
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03862817
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03751095
112DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03608103
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03276948
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02679636
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02088422
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.01429060
117TBX20_22328084_ChIP-Seq_HEART_Mouse1.00598116
118TBX20_22080862_ChIP-Seq_HEART_Mouse1.00598116
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00275750
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00190635
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00173036
122* FOXP3_21729870_ChIP-Seq_TREG_Human0.99820917
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99692467
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99670163
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99344038
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98755723
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.97827871
128TTF2_22483619_ChIP-Seq_HELA_Human0.96972016
129STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96203521
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95972591
131OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95735502
132* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95007583
133EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94526928
134RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94526928
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94467248
136NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94255715
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.94232854
138TP53_22127205_ChIP-Seq_IMR90_Human0.94117787
139FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93809924
140IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93387118
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92446680
142* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92145186
143SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91967288
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91471138
145SPI1_23127762_ChIP-Seq_K562_Human0.91326249
146* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89644532
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88449294
148ATF3_27146783_Chip-Seq_COLON_Human0.88342417
149STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88329317
150RACK7_27058665_Chip-Seq_MCF-7_Human0.87999947
151P68_20966046_ChIP-Seq_HELA_Human0.87712506
152CHD1_26751641_Chip-Seq_LNCaP_Human0.87451323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps2.66837391
2MP0005058_abnormal_lysosome_morphology2.61809906
3MP0002396_abnormal_hematopoietic_system2.52049363
4MP0003705_abnormal_hypodermis_morpholog2.44254831
5MP0005409_darkened_coat_color2.44036392
6MP0005257_abnormal_intraocular_pressure2.42993113
7MP0009278_abnormal_bone_marrow2.39200282
8MP0010094_abnormal_chromosome_stability2.31238234
9MP0004808_abnormal_hematopoietic_stem2.30857666
10MP0006054_spinal_hemorrhage2.28231700
11MP0003077_abnormal_cell_cycle2.24355413
12MP0003111_abnormal_nucleus_morphology2.24070191
13MP0004858_abnormal_nervous_system2.21802094
14MP0000566_synostosis2.19414722
15MP0000537_abnormal_urethra_morphology2.19266199
16MP0002822_catalepsy2.10127321
17MP0001346_abnormal_lacrimal_gland2.09737348
18MP0008007_abnormal_cellular_replicative2.08186093
19MP0010030_abnormal_orbit_morphology1.96914790
20MP0005451_abnormal_body_composition1.94760295
21MP0005410_abnormal_fertilization1.82610599
22MP0004957_abnormal_blastocyst_morpholog1.80703099
23MP0003191_abnormal_cellular_cholesterol1.79062724
24MP0010368_abnormal_lymphatic_system1.76369974
25MP0004185_abnormal_adipocyte_glucose1.72863033
26MP0003828_pulmonary_edema1.72168721
27MP0001730_embryonic_growth_arrest1.71999947
28MP0001545_abnormal_hematopoietic_system1.71091177
29MP0005397_hematopoietic_system_phenotyp1.71091177
30MP0008057_abnormal_DNA_replication1.68738323
31MP0005076_abnormal_cell_differentiation1.68124019
32MP0003123_paternal_imprinting1.64522851
33MP0003436_decreased_susceptibility_to1.64522431
34MP0000350_abnormal_cell_proliferation1.64039409
35MP0002653_abnormal_ependyma_morphology1.63147937
36MP0000685_abnormal_immune_system1.62638928
37MP0003693_abnormal_embryo_hatching1.60809668
38MP0005275_abnormal_skin_tensile1.53494187
39* MP0003984_embryonic_growth_retardation1.53110216
40* MP0002088_abnormal_embryonic_growth/wei1.52524214
41MP0001849_ear_inflammation1.51744960
42* MP0001672_abnormal_embryogenesis/_devel1.51712742
43* MP0005380_embryogenesis_phenotype1.51712742
44MP0003763_abnormal_thymus_physiology1.50984665
45MP0000733_abnormal_muscle_development1.50719513
46MP0004197_abnormal_fetal_growth/weight/1.48145396
47MP0001697_abnormal_embryo_size1.47080911
48MP0000703_abnormal_thymus_morphology1.46466781
49MP0008260_abnormal_autophagy1.46302248
50MP0003172_abnormal_lysosome_physiology1.42176543
51MP0004510_myositis1.40387490
52MP0000490_abnormal_crypts_of1.39234323
53MP0002398_abnormal_bone_marrow1.39183908
54MP0000751_myopathy1.39065528
55* MP0002084_abnormal_developmental_patter1.37888737
56* MP0002085_abnormal_embryonic_tissue1.37643956
57MP0002998_abnormal_bone_remodeling1.33665461
58MP0002086_abnormal_extraembryonic_tissu1.30494498
59MP0002932_abnormal_joint_morphology1.29701444
60MP0003300_gastrointestinal_ulcer1.28457926
61MP0003567_abnormal_fetal_cardiomyocyte1.27865127
62MP0001915_intracranial_hemorrhage1.27207178
63MP0008438_abnormal_cutaneous_collagen1.26276208
64MP0003566_abnormal_cell_adhesion1.25564982
65MP0005623_abnormal_meninges_morphology1.24938954
66MP0005503_abnormal_tendon_morphology1.22445424
67* MP0002080_prenatal_lethality1.21867652
68MP0001293_anophthalmia1.21697954
69* MP0002925_abnormal_cardiovascular_devel1.20504502
70MP0003115_abnormal_respiratory_system1.20469801
71MP0002722_abnormal_immune_system1.19841016
72MP0003121_genomic_imprinting1.19766239
73MP0005508_abnormal_skeleton_morphology1.18816371
74MP0009384_cardiac_valve_regurgitation1.18688424
75MP0005023_abnormal_wound_healing1.16607259
76MP0010307_abnormal_tumor_latency1.16200205
77MP0008058_abnormal_DNA_repair1.13692356
78MP0000689_abnormal_spleen_morphology1.13539801
79MP0000428_abnormal_craniofacial_morphol1.13514662
80MP0008961_abnormal_basal_metabolism1.12248021
81MP0003453_abnormal_keratinocyte_physiol1.09197454
82MP0001800_abnormal_humoral_immune1.09076830
83MP0000569_abnormal_digit_pigmentation1.08540721
84MP0002877_abnormal_melanocyte_morpholog1.07702843
85MP0008932_abnormal_embryonic_tissue1.06786361
86* MP0003279_aneurysm1.06751073
87MP0005248_abnormal_Harderian_gland1.06612178
88MP0009333_abnormal_splenocyte_physiolog1.04231339
89MP0001533_abnormal_skeleton_physiology1.02767837
90MP0001929_abnormal_gametogenesis1.02628268
91MP0009250_abnormal_appendicular_skeleto1.01584068
92MP0003935_abnormal_craniofacial_develop1.01569537
93MP0000313_abnormal_cell_death1.00858055
94MP0005390_skeleton_phenotype1.00558657
95MP0002796_impaired_skin_barrier1.00476746
96MP0002429_abnormal_blood_cell1.00382630
97MP0004381_abnormal_hair_follicle1.00180631
98MP0003942_abnormal_urinary_system1.00043514
99MP0003091_abnormal_cell_migration0.99679186
100MP0002089_abnormal_postnatal_growth/wei0.99645526
101MP0000716_abnormal_immune_system0.99013309
102MP0008004_abnormal_stomach_pH0.98942239
103MP0004947_skin_inflammation0.98502707
104MP0000516_abnormal_urinary_system0.98491682
105MP0005367_renal/urinary_system_phenotyp0.98491682
106MP0000767_abnormal_smooth_muscle0.98326116
107* MP0002019_abnormal_tumor_incidence0.98063453
108MP0000465_gastrointestinal_hemorrhage0.96801601
109MP0000858_altered_metastatic_potential0.95947281
110MP0001958_emphysema0.95861425
111MP0002452_abnormal_antigen_presenting0.95091611
112MP0010630_abnormal_cardiac_muscle0.93572549
113MP0004272_abnormal_basement_membrane0.93467863
114MP0005464_abnormal_platelet_physiology0.93445498
115MP0005197_abnormal_uvea_morphology0.93362768
116MP0002092_abnormal_eye_morphology0.93172085
117MP0003385_abnormal_body_wall0.93024525
118MP0000762_abnormal_tongue_morphology0.92289931
119MP0001879_abnormal_lymphatic_vessel0.91088149
120MP0003890_abnormal_embryonic-extraembry0.90825657
121MP0002282_abnormal_trachea_morphology0.90776784
122MP0009672_abnormal_birth_weight0.90178705
123MP0002896_abnormal_bone_mineralization0.90025492
124MP0002697_abnormal_eye_size0.89685714
125MP0001835_abnormal_antigen_presentation0.89398428
126* MP0001614_abnormal_blood_vessel0.87786872
127MP0005387_immune_system_phenotype0.86580181
128MP0001790_abnormal_immune_system0.86580181
129* MP0000266_abnormal_heart_morphology0.86162933
130MP0002420_abnormal_adaptive_immunity0.85989554
131MP0002249_abnormal_larynx_morphology0.85811121
132MP0003136_yellow_coat_color0.85801822
133MP0009840_abnormal_foam_cell0.85709319
134MP0000049_abnormal_middle_ear0.85449903
135MP0004264_abnormal_extraembryonic_tissu0.84864374
136MP0002113_abnormal_skeleton_development0.84823563
137MP0004233_abnormal_muscle_weight0.84776679
138MP0002405_respiratory_system_inflammati0.84588148
139MP0000534_abnormal_ureter_morphology0.84583843
140MP0009053_abnormal_anal_canal0.83762160
141MP0001819_abnormal_immune_cell0.83403506
142MP0002210_abnormal_sex_determination0.83260502
143MP0003943_abnormal_hepatobiliary_system0.83032235
144MP0002116_abnormal_craniofacial_bone0.81587041
145MP0000432_abnormal_head_morphology0.81583758
146MP0003303_peritoneal_inflammation0.81349826
147MP0006138_congestive_heart_failure0.80449286
148MP0001299_abnormal_eye_distance/0.80142422
149MP0000003_abnormal_adipose_tissue0.77412678
150MP0003938_abnormal_ear_development0.76102713
151MP0000747_muscle_weakness0.74674566
152MP0000759_abnormal_skeletal_muscle0.73863580
153MP0002933_joint_inflammation0.71742058
154* MP0005375_adipose_tissue_phenotype0.70270240
155MP0000750_abnormal_muscle_regeneration0.68916852
156MP0002114_abnormal_axial_skeleton0.68730296
157MP0003329_amyloid_beta_deposits0.68663449
158MP0000163_abnormal_cartilage_morphology0.66671857
159MP0005193_abnormal_anterior_eye0.66620855
160MP0000343_altered_response_to0.64235083
161MP0003634_abnormal_glial_cell0.63107106
162MP0002108_abnormal_muscle_morphology0.63075136

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.74435941
2* Short 4th metacarpal (HP:0010044)3.65933794
3* Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.65933794
4Premature rupture of membranes (HP:0001788)3.40945132
5Renal duplication (HP:0000075)3.39786141
6Protrusio acetabuli (HP:0003179)3.20107789
7Obstructive sleep apnea (HP:0002870)3.09345002
8Neonatal short-limb short stature (HP:0008921)3.04286303
9Abnormality of the fingertips (HP:0001211)3.00756067
10Nasal polyposis (HP:0100582)2.87174624
11Disproportionate tall stature (HP:0001519)2.75633854
12* Abnormality of the 4th metacarpal (HP:0010012)2.73131946
13Increased nuchal translucency (HP:0010880)2.70388285
14Shallow orbits (HP:0000586)2.66474515
15Abnormality of the nasal mucosa (HP:0000433)2.65616634
16Elfin facies (HP:0004428)2.60677766
17Vascular tortuosity (HP:0004948)2.60286855
18Cerebral aneurysm (HP:0004944)2.55904881
19Selective tooth agenesis (HP:0001592)2.55258457
20Broad palm (HP:0001169)2.46394800
21High pitched voice (HP:0001620)2.44742911
22Increased density of long bones (HP:0006392)2.44738466
23Ankle contracture (HP:0006466)2.44408057
24Premature skin wrinkling (HP:0100678)2.42689926
25Recurrent bronchitis (HP:0002837)2.39577575
26Broad face (HP:0000283)2.35946358
27Renovascular hypertension (HP:0100817)2.33571764
28Abnormality of the phalanges of the hallux (HP:0010057)2.32747410
29Trigonocephaly (HP:0000243)2.32204869
30Bowel diverticulosis (HP:0005222)2.31547580
31* Skin tags (HP:0010609)2.27084454
32Partial duplication of thumb phalanx (HP:0009944)2.26427030
33Aortic aneurysm (HP:0004942)2.24423932
34Thrombocytosis (HP:0001894)2.22034161
35Bladder diverticulum (HP:0000015)2.20744785
36Partial duplication of the phalanx of hand (HP:0009999)2.19863280
37Flat cornea (HP:0007720)2.19546341
38Long eyelashes (HP:0000527)2.19474672
39Arnold-Chiari malformation (HP:0002308)2.17558100
40Axonal loss (HP:0003447)2.16151546
41Abnormal number of incisors (HP:0011064)2.14592983
42Wide anterior fontanel (HP:0000260)2.14210243
43Ulnar bowing (HP:0003031)2.11777783
44Preauricular skin tag (HP:0000384)2.10794641
45Vertebral compression fractures (HP:0002953)2.10581683
46Cellulitis (HP:0100658)2.10504768
47Spinal rigidity (HP:0003306)2.10258541
48Spontaneous hematomas (HP:0007420)2.09136792
49Increased variability in muscle fiber diameter (HP:0003557)2.08822059
50Syringomyelia (HP:0003396)2.06454598
51Spinal cord lesions (HP:0100561)2.06454598
52Overriding aorta (HP:0002623)2.05527087
53Joint laxity (HP:0001388)2.04751737
54Fragile skin (HP:0001030)2.03732375
55Abnormality of the aortic arch (HP:0012303)2.02902612
56Bicuspid aortic valve (HP:0001647)2.01196252
57Aortic dissection (HP:0002647)1.99819650
58Increased connective tissue (HP:0009025)1.99531975
59Deviation of the thumb (HP:0009603)1.99344630
60Aplasia involving bones of the extremities (HP:0009825)1.99312554
61Aplasia involving bones of the upper limbs (HP:0009823)1.99312554
62Aplasia of the phalanges of the hand (HP:0009802)1.99312554
63Abnormality of the distal phalanges of the toes (HP:0010182)1.97308699
64Vertebral arch anomaly (HP:0008438)1.97091489
65Deviation of the hallux (HP:0010051)1.96642414
66IgM deficiency (HP:0002850)1.94901456
67Proximal placement of thumb (HP:0009623)1.94190026
68Hallux valgus (HP:0001822)1.93765986
69Bronchitis (HP:0012387)1.93152637
70Hyperextensible skin (HP:0000974)1.91853449
71Thin ribs (HP:0000883)1.91479076
72Camptodactyly of toe (HP:0001836)1.88584021
73Blue sclerae (HP:0000592)1.88554955
74Hypoplasia of the iris (HP:0007676)1.87745824
75Abnormality of skeletal muscle fiber size (HP:0012084)1.87304169
76Asymmetric septal hypertrophy (HP:0001670)1.85401406
77Soft skin (HP:0000977)1.84485826
78Aneurysm (HP:0002617)1.84473165
79Gastrointestinal inflammation (HP:0004386)1.84371097
80Broad hallux (HP:0010055)1.84282865
81Thoracic kyphosis (HP:0002942)1.84015879
82Asymmetry of the thorax (HP:0001555)1.83143718
83Abnormality of skull ossification (HP:0002703)1.83094458
84Mitral valve prolapse (HP:0001634)1.82488799
85Peritonitis (HP:0002586)1.80769991
86Wormian bones (HP:0002645)1.80474834
87Overlapping toe (HP:0001845)1.80027432
88Centrally nucleated skeletal muscle fibers (HP:0003687)1.79991585
89Metaphyseal cupping (HP:0003021)1.79534082
90Megalocornea (HP:0000485)1.79276423
91Abnormality of the thoracic spine (HP:0100711)1.78954153
92Broad metatarsal (HP:0001783)1.78549116
93Flat acetabular roof (HP:0003180)1.78337158
94Lymphangioma (HP:0100764)1.78313967
95Atrophic scars (HP:0001075)1.77897154
96Short 5th finger (HP:0009237)1.76654951
97Thin bony cortex (HP:0002753)1.75968576
98Spondylolisthesis (HP:0003302)1.75903009
99Genu recurvatum (HP:0002816)1.74925295
100Myopathic facies (HP:0002058)1.74850810
101Cervical subluxation (HP:0003308)1.73605846
102Broad distal phalanx of finger (HP:0009836)1.73596145
103Dislocated radial head (HP:0003083)1.72683854
104Rectal prolapse (HP:0002035)1.72672975
105Broad thumb (HP:0011304)1.72663231
106Dilatation of the ascending aorta (HP:0005111)1.72215976
107Broad toe (HP:0001837)1.72095920
108Germ cell neoplasia (HP:0100728)1.71944438
109Abnormality of the intervertebral disk (HP:0005108)1.71847635
110Alacrima (HP:0000522)1.71785220
111Cutis marmorata (HP:0000965)1.71754034
112Atresia of the external auditory canal (HP:0000413)1.71728809
113Papilloma (HP:0012740)1.71622367
114Verrucae (HP:0200043)1.71622367
115Panhypogammaglobulinemia (HP:0003139)1.71247456
116Distal lower limb amyotrophy (HP:0008944)1.70943890
117Reticulocytopenia (HP:0001896)1.70749776
118Persistence of primary teeth (HP:0006335)1.70627191
119Abnormal vertebral ossification (HP:0100569)1.70012272
120Distal lower limb muscle weakness (HP:0009053)1.69930445
121Colon cancer (HP:0003003)1.69471515
122Recurrent viral infections (HP:0004429)1.69077412
123Upper motor neuron abnormality (HP:0002127)1.68668729
124Ependymoma (HP:0002888)1.68125033
125Biconcave vertebral bodies (HP:0004586)1.67847821
126Dysostosis multiplex (HP:0000943)1.67691310
127Volvulus (HP:0002580)1.66687778
128* Abnormality of the parietal bone (HP:0002696)1.66685036
129Hematochezia (HP:0002573)1.66232435
130Insomnia (HP:0100785)1.65553799
131Abnormality of the radial head (HP:0003995)1.65422632
132Limited elbow extension (HP:0001377)1.65049962
133Abnormality of liposaccharide metabolism (HP:0010968)1.64666287
134Abnormality of glycosphingolipid metabolism (HP:0004343)1.64666287
135Abnormality of glycolipid metabolism (HP:0010969)1.64666287
136Abnormality of the diencephalon (HP:0010662)1.64398068
137Neonatal death (HP:0003811)1.63522305
138Joint contractures involving the joints of the feet (HP:0100492)1.63442511
139Flexion contracture of toe (HP:0005830)1.63442511
140Long palpebral fissure (HP:0000637)1.63295860
141Inflammation of the large intestine (HP:0002037)1.62877981
142Coronal craniosynostosis (HP:0004440)1.62342094
143Broad phalanges of the hand (HP:0009768)1.62342045
144Agammaglobulinemia (HP:0004432)1.61190406
145Purpura (HP:0000979)1.60832117
146Chronic otitis media (HP:0000389)1.60760030
147Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.60552143
148Short clavicles (HP:0000894)1.60411055
149Recurrent bacterial skin infections (HP:0005406)1.60201422
150Mesomelia (HP:0003027)1.59623378
151Abnormality of the calcaneus (HP:0008364)1.59548982
152Eczematoid dermatitis (HP:0000976)1.58719279
153Enlarged penis (HP:0000040)1.58232047
154Heterotopia (HP:0002282)1.57951333
155Pulmonary artery stenosis (HP:0004415)1.57573058
156Emphysema (HP:0002097)1.56553039
157Subacute progressive viral hepatitis (HP:0006572)1.56438387
158Turricephaly (HP:0000262)1.56138540
159* Abnormality of the distal phalanx of the thumb (HP:0009617)1.56114420
160Abnormality of incisor morphology (HP:0011063)1.56097471
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55324906
162Glossoptosis (HP:0000162)1.55316224
163Abnormality of the carotid arteries (HP:0005344)1.54809247
164Pointed chin (HP:0000307)1.51956184
165Arterial tortuosity (HP:0005116)1.51914956
166Mitral regurgitation (HP:0001653)1.51540913
167Colitis (HP:0002583)1.50821012
168Narrow palate (HP:0000189)1.50346804
169Skull defect (HP:0001362)1.49209289
170Urethral obstruction (HP:0000796)1.48783458
171Broad finger (HP:0001500)1.48714703
172Broad long bones (HP:0005622)1.45816034
173Abnormal delayed hypersensitivity skin test (HP:0002963)1.45749672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.54543345
2EEF2K4.34430692
3CDK123.44752772
4TRIB33.31893944
5PRPF4B3.04404418
6SMG12.92917621
7MAP4K12.73968933
8PKN22.66722019
9NEK22.46343310
10STK102.43310403
11CDC72.21640001
12ICK2.11432929
13ERN12.05301106
14LRRK21.81649269
15TGFBR11.58642851
16MARK21.53939456
17TESK11.52086175
18PAK41.51751007
19PDGFRA1.42531473
20CDK41.41370462
21RPS6KB21.36577975
22PASK1.36245573
23TTN1.34563076
24PTK61.34073018
25GRK61.33242011
26RPS6KA41.31664940
27BTK1.30195328
28JAK31.29102058
29CDC42BPA1.26891858
30MAP3K61.26204727
31TGFBR21.25133524
32CDK71.21821013
33MAP3K81.20072811
34SIK11.19749916
35CLK11.18692381
36PRKD31.18445321
37MTOR1.16192486
38BRD41.15390680
39KDR1.12624179
40NTRK11.12623613
41MAP3K31.12333233
42RPS6KA21.12176766
43DYRK31.07290966
44PAK21.05919438
45CSF1R1.05557718
46LATS11.05454824
47MKNK11.03743398
48NEK91.02689684
49RIPK11.01329042
50TTK1.00559170
51ATR0.99235593
52STK380.98335562
53KSR20.97898708
54LATS20.97082356
55STK30.93706115
56MAP2K30.91093176
57ZAP700.91018179
58PDK40.90498319
59PDK30.90498319
60CDK60.89900286
61BLK0.88966597
62DYRK1B0.88003866
63PIM10.87213041
64TYK20.86777931
65ALK0.85159692
66TAF10.83719555
67TAOK10.83651430
68EPHA20.81970282
69MOS0.80325607
70MAPK70.79622447
71PDPK10.79465454
72RPS6KC10.79130957
73RPS6KL10.79130957
74TESK20.78778497
75TIE10.78307752
76CDK90.78278864
77CHEK10.77309603
78CAMK1D0.77132378
79KSR10.76489845
80CSK0.76428761
81MELK0.76150932
82BMX0.74820276
83BUB10.74214299
84YES10.71410692
85MAP3K10.70343727
86STK40.69382641
87CHUK0.68656392
88KIT0.68497902
89FES0.67956191
90MAPKAPK30.66424817
91WEE10.62845936
92RIPK40.62750751
93NME20.62747003
94CAMK1G0.61265422
95FGFR10.60468355
96PDGFRB0.59784810
97AURKB0.59391568
98FGFR30.58303193
99PLK10.58236450
100TYRO30.58053628
101MAPK120.57953704
102FGFR40.57944000
103RPS6KA60.55929922
104RET0.55196083
105TNK20.54739634
106PNCK0.54601700
107SCYL20.53587958
108CHEK20.53411684
109ILK0.53272447
110PRKD20.52233070
111PINK10.52136490
112CDK20.52057663
113HIPK20.50245050
114ATM0.49518125
115ARAF0.48524093
116HCK0.47736653
117IRAK30.46901402
118MKNK20.45821171
119NLK0.45598610
120FGFR20.44934373
121PTK20.44213582
122PTK2B0.43910060
123TSSK60.43904095
124EPHB20.43636136
125PAK10.43396284
126SIK20.43336665
127DMPK0.43127559
128SIK30.42928305
129ITK0.40959183
130MAP3K130.40382597
131MATK0.39604497
132MARK30.39361218
133DDR20.39240983
134EPHB10.38876040
135MAP2K20.37923129
136MAPKAPK20.37565037
137CDK80.37080359
138PRKD10.36910050
139STK38L0.36850083
140MAP2K40.36770232
141PRKG20.36650200
142MAP3K70.36493141
143CAMK40.36321571
144STK110.35857242
145TAOK20.35800065
146MAP3K110.35116776
147EIF2AK10.34473941

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.11540087
2Base excision repair_Homo sapiens_hsa034102.45560399
3Mismatch repair_Homo sapiens_hsa034302.29299413
4Spliceosome_Homo sapiens_hsa030402.23543811
5Cell cycle_Homo sapiens_hsa041102.16931341
6Other glycan degradation_Homo sapiens_hsa005112.02627079
7RNA transport_Homo sapiens_hsa030131.96521471
8mRNA surveillance pathway_Homo sapiens_hsa030151.79663217
9Chronic myeloid leukemia_Homo sapiens_hsa052201.77594851
10Primary immunodeficiency_Homo sapiens_hsa053401.76422420
11B cell receptor signaling pathway_Homo sapiens_hsa046621.72227137
12Renal cell carcinoma_Homo sapiens_hsa052111.66680884
13Small cell lung cancer_Homo sapiens_hsa052221.59840079
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.59073361
15Notch signaling pathway_Homo sapiens_hsa043301.57980400
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54789805
17MicroRNAs in cancer_Homo sapiens_hsa052061.49722195
18HTLV-I infection_Homo sapiens_hsa051661.48774080
19Homologous recombination_Homo sapiens_hsa034401.42840602
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41507224
21Antigen processing and presentation_Homo sapiens_hsa046121.37908516
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36724636
23Herpes simplex infection_Homo sapiens_hsa051681.33690675
24* Basal cell carcinoma_Homo sapiens_hsa052171.33552934
25Nucleotide excision repair_Homo sapiens_hsa034201.32033631
26Amoebiasis_Homo sapiens_hsa051461.30697446
27ErbB signaling pathway_Homo sapiens_hsa040121.29097097
28Adherens junction_Homo sapiens_hsa045201.28742346
29p53 signaling pathway_Homo sapiens_hsa041151.28707048
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25880097
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.24547599
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24100958
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21631440
34Viral myocarditis_Homo sapiens_hsa054161.20292658
35Axon guidance_Homo sapiens_hsa043601.19041004
36Estrogen signaling pathway_Homo sapiens_hsa049151.18945060
37Colorectal cancer_Homo sapiens_hsa052101.18636881
38RNA degradation_Homo sapiens_hsa030181.17445509
39Lysosome_Homo sapiens_hsa041421.17272886
40Fanconi anemia pathway_Homo sapiens_hsa034601.14920589
41One carbon pool by folate_Homo sapiens_hsa006701.14831508
42Proteoglycans in cancer_Homo sapiens_hsa052051.13951031
43Viral carcinogenesis_Homo sapiens_hsa052031.13320192
44Acute myeloid leukemia_Homo sapiens_hsa052211.12952167
45Pancreatic cancer_Homo sapiens_hsa052121.12186303
46Lysine degradation_Homo sapiens_hsa003101.11475830
47Shigellosis_Homo sapiens_hsa051311.11473328
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10592355
49Measles_Homo sapiens_hsa051621.09677212
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09539559
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.08448789
52Epstein-Barr virus infection_Homo sapiens_hsa051691.08185564
53Prion diseases_Homo sapiens_hsa050201.07883429
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07794866
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.07509126
56Prolactin signaling pathway_Homo sapiens_hsa049171.06599310
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06160745
58Non-small cell lung cancer_Homo sapiens_hsa052231.04800694
59Central carbon metabolism in cancer_Homo sapiens_hsa052301.04674488
60Endocytosis_Homo sapiens_hsa041441.04605915
61Focal adhesion_Homo sapiens_hsa045101.03455726
62Hepatitis B_Homo sapiens_hsa051611.03321092
63Ribosome_Homo sapiens_hsa030101.03015504
64Hippo signaling pathway_Homo sapiens_hsa043901.01232307
65T cell receptor signaling pathway_Homo sapiens_hsa046601.00426525
66Toxoplasmosis_Homo sapiens_hsa051451.00176348
67VEGF signaling pathway_Homo sapiens_hsa043701.00075424
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99657392
69mTOR signaling pathway_Homo sapiens_hsa041500.99244081
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98511408
71* Hedgehog signaling pathway_Homo sapiens_hsa043400.96341960
72Inositol phosphate metabolism_Homo sapiens_hsa005620.96106220
73Insulin signaling pathway_Homo sapiens_hsa049100.95517387
74Gap junction_Homo sapiens_hsa045400.94680889
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94053678
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.93518127
77Choline metabolism in cancer_Homo sapiens_hsa052310.92496166
78Melanogenesis_Homo sapiens_hsa049160.91949813
79Thyroid cancer_Homo sapiens_hsa052160.91403216
80Non-homologous end-joining_Homo sapiens_hsa034500.89980099
81Endometrial cancer_Homo sapiens_hsa052130.89247184
82Leishmaniasis_Homo sapiens_hsa051400.89211742
83* Pathways in cancer_Homo sapiens_hsa052000.89002689
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86954145
85Osteoclast differentiation_Homo sapiens_hsa043800.86574536
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.86545972
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86457578
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86391961
89HIF-1 signaling pathway_Homo sapiens_hsa040660.85998936
90GnRH signaling pathway_Homo sapiens_hsa049120.85782928
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85760748
92Platelet activation_Homo sapiens_hsa046110.85157425
93ECM-receptor interaction_Homo sapiens_hsa045120.84293711
94Tuberculosis_Homo sapiens_hsa051520.83289469
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82780057
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82665829
97Basal transcription factors_Homo sapiens_hsa030220.80595007
98Oocyte meiosis_Homo sapiens_hsa041140.80340468
99Chemokine signaling pathway_Homo sapiens_hsa040620.79874627
100Apoptosis_Homo sapiens_hsa042100.79428433
101Legionellosis_Homo sapiens_hsa051340.78477300
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77989917
103Hepatitis C_Homo sapiens_hsa051600.76652499
104Prostate cancer_Homo sapiens_hsa052150.74165111
105Phagosome_Homo sapiens_hsa041450.73909401
106Malaria_Homo sapiens_hsa051440.72266957
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.71637788
108Bladder cancer_Homo sapiens_hsa052190.70951948
109Influenza A_Homo sapiens_hsa051640.70726223
110Pyrimidine metabolism_Homo sapiens_hsa002400.70593710
111Dilated cardiomyopathy_Homo sapiens_hsa054140.69674394
112TGF-beta signaling pathway_Homo sapiens_hsa043500.69243771
113Hematopoietic cell lineage_Homo sapiens_hsa046400.68503865
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.67966976
115Wnt signaling pathway_Homo sapiens_hsa043100.67087148
116Glioma_Homo sapiens_hsa052140.66688096
117MAPK signaling pathway_Homo sapiens_hsa040100.65817962
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65754847
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64644414
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64572672
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64468806
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61806585
123Dorso-ventral axis formation_Homo sapiens_hsa043200.61218351
124TNF signaling pathway_Homo sapiens_hsa046680.61097601
125Insulin resistance_Homo sapiens_hsa049310.60077509
126Salmonella infection_Homo sapiens_hsa051320.59855458
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59534799
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59529453
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57849605
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57656398
131Ras signaling pathway_Homo sapiens_hsa040140.57634352
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.57147122
133Rap1 signaling pathway_Homo sapiens_hsa040150.55312059
134Staphylococcus aureus infection_Homo sapiens_hsa051500.55013818
135FoxO signaling pathway_Homo sapiens_hsa040680.53913501
136Pentose phosphate pathway_Homo sapiens_hsa000300.53569328
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52707568
138RNA polymerase_Homo sapiens_hsa030200.52596063
139Galactose metabolism_Homo sapiens_hsa000520.52262580
140Sulfur relay system_Homo sapiens_hsa041220.51815927
141AMPK signaling pathway_Homo sapiens_hsa041520.51747237

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