SUGCT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.40379600
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.40379600
3L-phenylalanine metabolic process (GO:0006558)7.11589793
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.11589793
5aromatic amino acid family catabolic process (GO:0009074)6.88849094
6indole-containing compound catabolic process (GO:0042436)6.38390811
7indolalkylamine catabolic process (GO:0046218)6.38390811
8tryptophan catabolic process (GO:0006569)6.38390811
9glyoxylate metabolic process (GO:0046487)6.27699142
10cysteine metabolic process (GO:0006534)6.14519793
11kynurenine metabolic process (GO:0070189)6.07888543
12tryptophan metabolic process (GO:0006568)6.03216765
13lysine metabolic process (GO:0006553)5.82905122
14lysine catabolic process (GO:0006554)5.82905122
15bile acid biosynthetic process (GO:0006699)5.71999905
16alpha-linolenic acid metabolic process (GO:0036109)5.40465522
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.38867164
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.38450335
19sulfur amino acid catabolic process (GO:0000098)5.34892247
20serine family amino acid catabolic process (GO:0009071)5.27638314
21homocysteine metabolic process (GO:0050667)5.10032002
22urate metabolic process (GO:0046415)5.05606462
23urea cycle (GO:0000050)5.04062353
24urea metabolic process (GO:0019627)5.04062353
25aromatic amino acid family metabolic process (GO:0009072)5.01309405
26drug transmembrane transport (GO:0006855)5.00259316
27amino-acid betaine metabolic process (GO:0006577)4.97582449
28bile acid metabolic process (GO:0008206)4.86829304
29alpha-amino acid catabolic process (GO:1901606)4.73236549
30nitrogen cycle metabolic process (GO:0071941)4.67941098
31cellular ketone body metabolic process (GO:0046950)4.63888394
32regulation of meiosis I (GO:0060631)4.63413292
33high-density lipoprotein particle remodeling (GO:0034375)4.61673401
34drug catabolic process (GO:0042737)4.61480179
35negative regulation of fibrinolysis (GO:0051918)4.61398185
36peptidyl-glutamic acid carboxylation (GO:0017187)4.55810836
37protein carboxylation (GO:0018214)4.55810836
38tyrosine metabolic process (GO:0006570)4.53968657
39indolalkylamine metabolic process (GO:0006586)4.52523920
40serine family amino acid metabolic process (GO:0009069)4.52483832
41complement activation, alternative pathway (GO:0006957)4.52326631
42cellular amino acid catabolic process (GO:0009063)4.45801590
43regulation of protein activation cascade (GO:2000257)4.43070629
44short-chain fatty acid metabolic process (GO:0046459)4.41259548
45cellular modified amino acid catabolic process (GO:0042219)4.41171882
46regulation of fibrinolysis (GO:0051917)4.40871867
47glutamate metabolic process (GO:0006536)4.40476259
48amine catabolic process (GO:0009310)4.40003250
49cellular biogenic amine catabolic process (GO:0042402)4.40003250
50benzene-containing compound metabolic process (GO:0042537)4.25514717
51drug transport (GO:0015893)4.22505876
52coenzyme catabolic process (GO:0009109)4.21027102
53ethanol oxidation (GO:0006069)4.19873228
54exogenous drug catabolic process (GO:0042738)4.18953943
55serine family amino acid biosynthetic process (GO:0009070)4.17862334
56glycine metabolic process (GO:0006544)4.17742434
57cellular glucuronidation (GO:0052695)4.17281667
58regulation of complement activation (GO:0030449)4.16360508
59aspartate family amino acid catabolic process (GO:0009068)4.16318567
60negative regulation of cholesterol transport (GO:0032375)4.15530909
61negative regulation of sterol transport (GO:0032372)4.15530909
62regulation of triglyceride catabolic process (GO:0010896)4.12178722
63bile acid and bile salt transport (GO:0015721)4.10384152
64acetyl-CoA metabolic process (GO:0006084)4.09506290
65regulation of cholesterol esterification (GO:0010872)4.06468392
66aldehyde catabolic process (GO:0046185)4.05583734
67reverse cholesterol transport (GO:0043691)4.05082792
68plasma lipoprotein particle remodeling (GO:0034369)4.04617221
69protein-lipid complex remodeling (GO:0034368)4.04617221
70macromolecular complex remodeling (GO:0034367)4.04617221
71ketone body metabolic process (GO:1902224)4.01166244
72acylglycerol homeostasis (GO:0055090)4.00647368
73triglyceride homeostasis (GO:0070328)4.00647368
742-oxoglutarate metabolic process (GO:0006103)3.99572729
75organic acid catabolic process (GO:0016054)3.98957151
76carboxylic acid catabolic process (GO:0046395)3.98957151
77fatty acid beta-oxidation (GO:0006635)3.98544691
78dicarboxylic acid biosynthetic process (GO:0043650)3.93925934
79fatty acid oxidation (GO:0019395)3.92016653
80lipid oxidation (GO:0034440)3.84869099
81carnitine metabolic process (GO:0009437)3.84706746
82valine metabolic process (GO:0006573)3.81351807
83uronic acid metabolic process (GO:0006063)3.81118987
84glucuronate metabolic process (GO:0019585)3.81118987
85monocarboxylic acid catabolic process (GO:0072329)3.80462570
86fatty acid catabolic process (GO:0009062)3.74304609
87arginine metabolic process (GO:0006525)3.73450690
88phospholipid efflux (GO:0033700)3.72404471
89imidazole-containing compound metabolic process (GO:0052803)3.71374398
90proteasome assembly (GO:0043248)3.67668503
91low-density lipoprotein particle remodeling (GO:0034374)3.65484590
92plasma lipoprotein particle clearance (GO:0034381)3.65115174
93response to mercury ion (GO:0046689)3.62854983
94regulation of cholesterol homeostasis (GO:2000188)3.60380425
95mitotic metaphase plate congression (GO:0007080)3.59932423
96regulation of bile acid biosynthetic process (GO:0070857)3.53145246
97drug metabolic process (GO:0017144)3.51781800
98branched-chain amino acid metabolic process (GO:0009081)3.50079937
99branched-chain amino acid catabolic process (GO:0009083)3.49775089
100negative regulation of lipase activity (GO:0060192)3.48667137
101response to nitrosative stress (GO:0051409)3.46854258
102cofactor catabolic process (GO:0051187)3.45169697
103very long-chain fatty acid metabolic process (GO:0000038)3.42728595
104nicotinamide nucleotide biosynthetic process (GO:0019359)3.41663634
105cullin deneddylation (GO:0010388)3.25396613
106regulation of DNA methylation (GO:0044030)3.24667010
107protein localization to kinetochore (GO:0034501)3.18736497
108protein localization to chromosome, centromeric region (GO:0071459)3.16301606
109regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.00784775
110regulation of plasminogen activation (GO:0010755)3.00687755
111metaphase plate congression (GO:0051310)2.96028338
112protein deneddylation (GO:0000338)2.95908602
113response to redox state (GO:0051775)2.87703997
114collagen fibril organization (GO:0030199)2.87577621
115piRNA metabolic process (GO:0034587)2.86078292
116nucleotide-sugar biosynthetic process (GO:0009226)2.78398696
117regulation of female gonad development (GO:2000194)2.77765986
118ventricular cardiac muscle cell development (GO:0055015)2.71959189
119meiotic cell cycle (GO:0051321)2.70994726
120establishment of chromosome localization (GO:0051303)2.66911228
121endodermal cell differentiation (GO:0035987)2.58409308
122transcription elongation from RNA polymerase I promoter (GO:0006362)2.57834517
123mesenchymal-epithelial cell signaling (GO:0060638)2.57291081
124positive regulation of male gonad development (GO:2000020)2.56489886
125COPII vesicle coating (GO:0048208)2.55942893
126fibrinolysis (GO:0042730)2.54383308
127anterior/posterior axis specification, embryo (GO:0008595)2.53710316
128chaperone-mediated protein transport (GO:0072321)2.49653219
129female gamete generation (GO:0007292)2.46874596
130peptidyl-proline hydroxylation (GO:0019511)2.45180097
131CENP-A containing nucleosome assembly (GO:0034080)2.43536937
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42210384
133ribosomal large subunit biogenesis (GO:0042273)2.41534973
134attachment of spindle microtubules to kinetochore (GO:0008608)2.41138016
135positive regulation of cellular amine metabolic process (GO:0033240)2.38908893
136regulation of acrosome reaction (GO:0060046)2.38722540
137regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.37661676
138paraxial mesoderm development (GO:0048339)2.33657643
139mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.33537938
140termination of RNA polymerase I transcription (GO:0006363)2.25892266
141mitotic chromosome condensation (GO:0007076)2.25550817
142retinal cone cell development (GO:0046549)2.24000086
143chondrocyte proliferation (GO:0035988)2.22928000
144oocyte development (GO:0048599)2.22791177
145cholesterol efflux (GO:0033344)2.22301882
146positive regulation of gastrulation (GO:2000543)2.21674705
147cell migration involved in heart development (GO:0060973)2.21018102
148tricarboxylic acid cycle (GO:0006099)2.20703763
149regulation of spindle organization (GO:0090224)2.20479061
150ribosome assembly (GO:0042255)2.20196340
151hemidesmosome assembly (GO:0031581)2.19501391
152nucleotide transmembrane transport (GO:1901679)2.17203173
153chromatin remodeling at centromere (GO:0031055)2.15272579
154regulation of cell maturation (GO:1903429)2.14961797
155plasma lipoprotein particle assembly (GO:0034377)2.14705341
156type B pancreatic cell proliferation (GO:0044342)2.13435952
157positive regulation of mitotic sister chromatid separation (GO:1901970)2.13334707
158positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.13334707
159positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.13334707
160negative regulation of chondrocyte differentiation (GO:0032331)2.13294052
161negative regulation of reproductive process (GO:2000242)2.12875751
162female gonad development (GO:0008585)2.12816617
163oxidative demethylation (GO:0070989)2.11472355
1647-methylguanosine mRNA capping (GO:0006370)2.10772049
165negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.10574494
166regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.07398100
167regulation of meiosis (GO:0040020)2.06712750
168histone exchange (GO:0043486)2.06038624
169regulation of retinoic acid receptor signaling pathway (GO:0048385)2.05199947
170binding of sperm to zona pellucida (GO:0007339)2.04698382
171synapsis (GO:0007129)2.03995400
172doxorubicin metabolic process (GO:0044598)2.03942854
173daunorubicin metabolic process (GO:0044597)2.03942854
174polyketide metabolic process (GO:0030638)2.03942854
1757-methylguanosine RNA capping (GO:0009452)2.03450801
176RNA capping (GO:0036260)2.03450801
177positive regulation of meiosis (GO:0045836)2.03228556
178primitive streak formation (GO:0090009)2.02243535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.16060792
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.99786915
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.50628376
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.25674231
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.10169606
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.84558715
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.58459855
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.80864373
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.74663566
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49258636
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.40983349
12TRIM28_21343339_ChIP-Seq_HEK293_Human3.25466776
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63677274
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.53110302
15EZH2_22144423_ChIP-Seq_EOC_Human2.42764855
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32598697
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.32434984
18AR_21909140_ChIP-Seq_LNCAP_Human2.28986787
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18539185
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10066211
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05984499
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4594675
23ELK1_19687146_ChIP-ChIP_HELA_Human1.98298824
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.95627049
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.90264130
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85074286
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.84158550
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84128313
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80837549
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.77387392
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68268366
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66656223
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.62407025
34CLOCK_20551151_ChIP-Seq_293T_Human1.61719619
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.60811890
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.58576832
37DCP1A_22483619_ChIP-Seq_HELA_Human1.55439159
38GBX2_23144817_ChIP-Seq_PC3_Human1.54486844
39TP53_16413492_ChIP-PET_HCT116_Human1.53164350
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51280689
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49973002
42HNF4A_19822575_ChIP-Seq_HepG2_Human1.47922789
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47018736
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46097000
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.45698825
46TP53_18474530_ChIP-ChIP_U2OS_Human1.43110225
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42942394
48BRD4_25478319_ChIP-Seq_HGPS_Human1.42036159
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38619220
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34587653
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34204700
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33839235
53CJUN_26792858_Chip-Seq_BT549_Human1.30897713
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.30004656
55FUS_26573619_Chip-Seq_HEK293_Human1.28914762
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28816016
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28499778
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.27905221
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25753295
60MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.25013358
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23347424
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22908554
63E2F7_22180533_ChIP-Seq_HELA_Human1.22021007
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21982541
65HTT_18923047_ChIP-ChIP_STHdh_Human1.21490237
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20738824
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20583258
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18000827
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17519090
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17368205
71GATA1_22025678_ChIP-Seq_K562_Human1.15877686
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.15811127
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15032479
74SOX17_20123909_ChIP-Seq_XEN_Mouse1.14966369
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12800534
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12786325
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12595852
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10705123
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10356964
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10119439
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08919471
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08768682
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08115390
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07307872
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07163546
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06148938
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.05864786
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04755848
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04755848
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04755848
91FOXP3_21729870_ChIP-Seq_TREG_Human1.03772281
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02483018
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02422470
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00496288
95SALL4_22934838_ChIP-ChIP_CD34+_Human1.00280040
96GATA4_25053715_ChIP-Seq_YYC3_Human0.99165811
97ESR1_21235772_ChIP-Seq_MCF-7_Human0.97613621
98MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97600893
99VDR_23849224_ChIP-Seq_CD4+_Human0.97462869
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97317997
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97101666
102ESR2_21235772_ChIP-Seq_MCF-7_Human0.96335671
103EWS_26573619_Chip-Seq_HEK293_Human0.93534023
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93430958
105CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92540240
106IRF8_22096565_ChIP-ChIP_GC-B_Human0.91333896
107IRF1_19129219_ChIP-ChIP_H3396_Human0.90660066
108NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88712903
109GABP_19822575_ChIP-Seq_HepG2_Human0.87540589
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87506067
111TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87482364
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.87120663
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85568591
114ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84442648
115TTF2_22483619_ChIP-Seq_HELA_Human0.84425281
116EOMES_21245162_ChIP-Seq_HESCs_Human0.83186681
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79640269
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79523107
119KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78257146
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75984265
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74887117
122EGR1_19032775_ChIP-ChIP_M12_Human0.74296176
123AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74102614
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73916435
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73098118
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72559594
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71862881
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71640727
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.71168286
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70616634
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69564448
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69564448
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69249051
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68191093
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67900099
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.66612006
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65797342
138LXR_22292898_ChIP-Seq_THP-1_Human0.64503332
139AR_20517297_ChIP-Seq_VCAP_Human0.64474984
140E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.62724136
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.62125359
142ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61578321
143CEBPB_22108803_ChIP-Seq_LS180_Human0.61166690
144ZNF263_19887448_ChIP-Seq_K562_Human0.59854328
145STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57952545
146MYC_19915707_ChIP-ChIP_AK7_Human0.56720452
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.56226924
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.55928369
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.55095055
150STAT1_17558387_ChIP-Seq_HELA_Human0.54459764
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.53874284
152GATA6_25053715_ChIP-Seq_YYC3_Human0.53806491
153RARB_24833708_ChIP-Seq_LIVER_Mouse0.53534875
154FOXO3_23340844_ChIP-Seq_DLD1_Human0.53334158
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53242461
156PPAR_26484153_Chip-Seq_NCI-H1993_Human0.51359752
157CBP_21632823_ChIP-Seq_H3396_Human0.51068702
158GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.51039947
159PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50955720
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.48900468
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48814505
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48413401
163FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48375291
164SOX2_20726797_ChIP-Seq_SW620_Human0.47368080
165SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.46939196
166TAF2_19829295_ChIP-Seq_ESCs_Human0.46540401
167GATA2_19941826_ChIP-Seq_K562_Human0.46379553
168GATA1_19941827_ChIP-Seq_MEL_Mouse0.46090662
169FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.46053537
170PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45019388
171GATA1_19941826_ChIP-Seq_K562_Human0.44518093
172BCAT_22108803_ChIP-Seq_LS180_Human0.44361080
173P53_21459846_ChIP-Seq_SAOS-2_Human0.44185872
174CDX2_22108803_ChIP-Seq_LS180_Human0.42939319
175SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42844937
176GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.42784882
177P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.42362174
178FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.42096686
179ERG_20517297_ChIP-Seq_VCAP_Human0.41872235
180ERG_21242973_ChIP-ChIP_JURKAT_Human0.41645169
181FOXH1_21741376_ChIP-Seq_EPCs_Human0.38474521
182GATA3_24758297_ChIP-Seq_MCF-7_Human0.38228665
183CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.37997137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.09591914
2MP0005360_urolithiasis7.91798923
3MP0005085_abnormal_gallbladder_physiolo5.94682025
4MP0005365_abnormal_bile_salt5.81898378
5MP0008875_abnormal_xenobiotic_pharmacok5.05770522
6MP0008438_abnormal_cutaneous_collagen4.23513673
7MP0003806_abnormal_nucleotide_metabolis3.98916210
8MP0003252_abnormal_bile_duct3.84544713
9MP0003950_abnormal_plasma_membrane3.43216607
10MP0005332_abnormal_amino_acid3.42550710
11MP0010329_abnormal_lipoprotein_level3.21592604
12MP0003195_calcinosis3.20714015
13MP0004019_abnormal_vitamin_homeostasis2.97843594
14MP0003941_abnormal_skin_development2.90740616
15MP0005503_abnormal_tendon_morphology2.72278351
16MP0009840_abnormal_foam_cell2.68827897
17MP0010030_abnormal_orbit_morphology2.67720131
18MP0005275_abnormal_skin_tensile2.56825095
19MP0004272_abnormal_basement_membrane2.54925415
20MP0005083_abnormal_biliary_tract2.51795626
21MP0002138_abnormal_hepatobiliary_system2.47202830
22MP0001666_abnormal_nutrient_absorption2.41151932
23MP0003191_abnormal_cellular_cholesterol2.00382422
24MP0002118_abnormal_lipid_homeostasis2.00339052
25MP0009780_abnormal_chondrocyte_physiolo1.95572057
26MP0000609_abnormal_liver_physiology1.95176729
27MP0000762_abnormal_tongue_morphology1.94730372
28MP0009643_abnormal_urine_homeostasis1.88564947
29MP0005319_abnormal_enzyme/_coenzyme1.83974305
30MP0008789_abnormal_olfactory_epithelium1.83796339
31MP0001764_abnormal_homeostasis1.76540183
32MP0005584_abnormal_enzyme/coenzyme_acti1.70874691
33MP0003868_abnormal_feces_composition1.70444570
34MP0002234_abnormal_pharynx_morphology1.62993058
35MP0003186_abnormal_redox_activity1.62554831
36MP0000751_myopathy1.60254258
37MP0000749_muscle_degeneration1.58609500
38MP0003011_delayed_dark_adaptation1.56738362
39MP0009250_abnormal_appendicular_skeleto1.56702376
40MP0005451_abnormal_body_composition1.55130357
41MP0006054_spinal_hemorrhage1.55075383
42MP0005023_abnormal_wound_healing1.47689224
43MP0008932_abnormal_embryonic_tissue1.43363096
44MP0004043_abnormal_pH_regulation1.42646969
45MP0005636_abnormal_mineral_homeostasis1.41104167
46MP0006292_abnormal_olfactory_placode1.39527371
47MP0001299_abnormal_eye_distance/1.33181304
48MP0005623_abnormal_meninges_morphology1.32728495
49MP0009697_abnormal_copulation1.28983965
50MP0008058_abnormal_DNA_repair1.26622271
51MP0003077_abnormal_cell_cycle1.23901870
52MP0005508_abnormal_skeleton_morphology1.23325333
53MP0005257_abnormal_intraocular_pressure1.22727330
54MP0002108_abnormal_muscle_morphology1.22724426
55MP0003385_abnormal_body_wall1.21378492
56MP0002233_abnormal_nose_morphology1.21041789
57MP0004957_abnormal_blastocyst_morpholog1.19538383
58MP0003755_abnormal_palate_morphology1.18020824
59MP0000733_abnormal_muscle_development1.17712842
60MP0001756_abnormal_urination1.16082710
61MP0003693_abnormal_embryo_hatching1.15383311
62MP0002160_abnormal_reproductive_system1.15145510
63MP0005171_absent_coat_pigmentation1.14443523
64MP0000598_abnormal_liver_morphology1.11167569
65MP0003656_abnormal_erythrocyte_physiolo1.09406294
66MP0002295_abnormal_pulmonary_circulatio1.09206196
67MP0003279_aneurysm1.08211576
68MP0005670_abnormal_white_adipose1.08077167
69MP0009764_decreased_sensitivity_to1.07817943
70MP0006036_abnormal_mitochondrial_physio1.06783716
71MP0005394_taste/olfaction_phenotype1.02396286
72MP0005499_abnormal_olfactory_system1.02396286
73MP0005084_abnormal_gallbladder_morpholo1.02222690
74MP0001542_abnormal_bone_strength1.01719277
75MP0004084_abnormal_cardiac_muscle0.99611548
76MP0002136_abnormal_kidney_physiology0.99181947
77MP0003566_abnormal_cell_adhesion0.98191764
78MP0005647_abnormal_sex_gland0.97781581
79MP0003879_abnormal_hair_cell0.97252512
80MP0002876_abnormal_thyroid_physiology0.96566914
81MP0001765_abnormal_ion_homeostasis0.94408222
82MP0003937_abnormal_limbs/digits/tail_de0.93608766
83MP0002060_abnormal_skin_morphology0.92977669
84MP0002269_muscular_atrophy0.92263339
85MP0000049_abnormal_middle_ear0.91603323
86MP0002938_white_spotting0.91576799
87MP0001293_anophthalmia0.91521498
88MP0009642_abnormal_blood_homeostasis0.89983381
89MP0000604_amyloidosis0.89937957
90MP0003136_yellow_coat_color0.89252843
91MP0000759_abnormal_skeletal_muscle0.87852725
92MP0010094_abnormal_chromosome_stability0.86935961
93MP0009763_increased_sensitivity_to0.86558854
94MP0005535_abnormal_body_temperature0.86548268
95MP0003111_abnormal_nucleus_morphology0.86249756
96MP0008469_abnormal_protein_level0.86025701
97MP0005410_abnormal_fertilization0.85768509
98MP0003705_abnormal_hypodermis_morpholog0.85613684
99MP0002697_abnormal_eye_size0.81175388
100MP0005408_hypopigmentation0.80767394
101MP0003699_abnormal_female_reproductive0.80189508
102MP0010386_abnormal_urinary_bladder0.79986075
103MP0002078_abnormal_glucose_homeostasis0.79591269
104MP0003935_abnormal_craniofacial_develop0.79100913
105MP0004036_abnormal_muscle_relaxation0.78835510
106MP0004145_abnormal_muscle_electrophysio0.78018902
107MP0004215_abnormal_myocardial_fiber0.76239825
108MP0005220_abnormal_exocrine_pancreas0.75923391
109MP0005187_abnormal_penis_morphology0.75870210
110MP0005376_homeostasis/metabolism_phenot0.75421631
111MP0001929_abnormal_gametogenesis0.73592346
112MP0009765_abnormal_xenobiotic_induced0.72901332
113MP0000750_abnormal_muscle_regeneration0.72824448
114MP0002210_abnormal_sex_determination0.72166776
115MP0002971_abnormal_brown_adipose0.70234362
116MP0002928_abnormal_bile_duct0.70004886
117MP0001730_embryonic_growth_arrest0.69157431
118MP0005666_abnormal_adipose_tissue0.68278635
119MP0003890_abnormal_embryonic-extraembry0.67616109
120MP0005197_abnormal_uvea_morphology0.67311894
121MP0005058_abnormal_lysosome_morphology0.66943683
122MP0000534_abnormal_ureter_morphology0.66551399
123MP0000467_abnormal_esophagus_morphology0.66475405
124MP0003329_amyloid_beta_deposits0.66179183
125MP0001915_intracranial_hemorrhage0.65989153
126MP0000653_abnormal_sex_gland0.65831218
127MP0005334_abnormal_fat_pad0.65776438
128MP0002254_reproductive_system_inflammat0.65251795
129MP0001661_extended_life_span0.65179255
130MP0010368_abnormal_lymphatic_system0.64332930
131MP0004087_abnormal_muscle_fiber0.62844662
132MP0005330_cardiomyopathy0.62806260
133MP0002085_abnormal_embryonic_tissue0.62486550
134MP0004130_abnormal_muscle_cell0.62039912
135MP0006035_abnormal_mitochondrial_morpho0.61870076
136MP0005266_abnormal_metabolism0.57954714
137MP0000230_abnormal_systemic_arterial0.57284033
138MP0003690_abnormal_glial_cell0.57273831
139MP0003638_abnormal_response/metabolism_0.55813933
140MP0002168_other_aberrant_phenotype0.55428591
141MP0005395_other_phenotype0.53274440
142MP0003953_abnormal_hormone_level0.46964230
143MP0000538_abnormal_urinary_bladder0.46795533
144MP0003724_increased_susceptibility_to0.45843213
145MP0005448_abnormal_energy_balance0.43643099
146MP0003075_altered_response_to0.41863058
147MP0000639_abnormal_adrenal_gland0.41096471
148MP0002135_abnormal_kidney_morphology0.40660883
149MP0005166_decreased_susceptibility_to0.40352600
150MP0008874_decreased_physiological_sensi0.40180545
151MP0005464_abnormal_platelet_physiology0.38912025
152MP0008872_abnormal_physiological_respon0.37618305
153MP0002796_impaired_skin_barrier0.37313981
154MP0008961_abnormal_basal_metabolism0.37139991
155MP0004782_abnormal_surfactant_physiolog0.37051885
156MP0009115_abnormal_fat_cell0.35593758
157MP0004147_increased_porphyrin_level0.34817113
158MP0008873_increased_physiological_sensi0.33566442
159MP0003300_gastrointestinal_ulcer0.33444540
160MP0003959_abnormal_lean_body0.33439479
161MP0009053_abnormal_anal_canal0.32249305
162MP0001958_emphysema0.31316402
163MP0009672_abnormal_birth_weight0.30043233
164MP0002970_abnormal_white_adipose0.29671817
165MP0009384_cardiac_valve_regurgitation0.29481208
166MP0004264_abnormal_extraembryonic_tissu0.29417107
167MP0003718_maternal_effect0.29392999
168MP0002837_dystrophic_cardiac_calcinosis0.29294017
169MP0001845_abnormal_inflammatory_respons0.28531788
170MP0001944_abnormal_pancreas_morphology0.27864265
171MP0000249_abnormal_blood_vessel0.26244944
172MP0005595_abnormal_vascular_smooth0.25504670
173MP0001853_heart_inflammation0.24075837

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.69671760
2Intrahepatic cholestasis (HP:0001406)6.37128892
3Deep venous thrombosis (HP:0002625)5.98367576
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.72262889
5Xanthomatosis (HP:0000991)5.57428422
6Prolonged partial thromboplastin time (HP:0003645)5.12806003
7Hypobetalipoproteinemia (HP:0003563)5.12083435
8Hyperglycinuria (HP:0003108)4.90894777
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.76260759
10Ketosis (HP:0001946)4.73327843
11Hyperammonemia (HP:0001987)4.62080288
12Hyperglycinemia (HP:0002154)4.59873781
13Abnormality of glycine metabolism (HP:0010895)4.57989951
14Abnormality of serine family amino acid metabolism (HP:0010894)4.57989951
15Hyperlipoproteinemia (HP:0010980)4.57444166
16Abnormality of aspartate family amino acid metabolism (HP:0010899)4.29660152
17Complement deficiency (HP:0004431)4.25101888
18Premature rupture of membranes (HP:0001788)4.21401162
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.20839833
20Gout (HP:0001997)4.15679817
21Abnormality of fatty-acid metabolism (HP:0004359)4.01032121
22Hypolipoproteinemia (HP:0010981)3.96449870
23Ketoacidosis (HP:0001993)3.93953724
24Joint hemorrhage (HP:0005261)3.91325177
25Hypoglycemic coma (HP:0001325)3.85935281
26Epidermoid cyst (HP:0200040)3.79731808
27Abnormality of purine metabolism (HP:0004352)3.71616548
28Fat malabsorption (HP:0002630)3.71427225
29Abnormality of methionine metabolism (HP:0010901)3.65721150
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.61991399
31Abnormality of nucleobase metabolism (HP:0010932)3.60969212
32Hypoalphalipoproteinemia (HP:0003233)3.57844455
33Abnormality of the common coagulation pathway (HP:0010990)3.55633831
34Protrusio acetabuli (HP:0003179)3.55005683
35Delayed CNS myelination (HP:0002188)3.43528501
36Abnormality of pyrimidine metabolism (HP:0004353)3.39674542
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39410230
38Popliteal pterygium (HP:0009756)3.37071544
39Generalized aminoaciduria (HP:0002909)3.29061260
40Supernumerary spleens (HP:0009799)3.25192506
41Proximal tubulopathy (HP:0000114)3.21712910
42Vascular calcification (HP:0004934)3.17124697
43Hyperuricemia (HP:0002149)3.16068729
44Increased purine levels (HP:0004368)3.16068729
45Metabolic acidosis (HP:0001942)3.13580090
46Conjugated hyperbilirubinemia (HP:0002908)3.12850689
47Abnormality of serum amino acid levels (HP:0003112)3.11452370
48Abnormality of the intrinsic pathway (HP:0010989)3.06108330
49Hyperbilirubinemia (HP:0002904)3.05899502
50Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04300432
51Dicarboxylic aciduria (HP:0003215)3.04300432
52Abnormality of placental membranes (HP:0011409)3.02737911
53Amniotic constriction ring (HP:0009775)3.02737911
54Ankle contracture (HP:0006466)3.02170863
55Abnormality of complement system (HP:0005339)3.01557362
56Lethargy (HP:0001254)2.93782966
57Hypercholesterolemia (HP:0003124)2.93346439
58Alkalosis (HP:0001948)2.90398712
59Osteomalacia (HP:0002749)2.85431285
60Steatorrhea (HP:0002570)2.84015863
61Cardiovascular calcification (HP:0011915)2.82332504
62Follicular hyperkeratosis (HP:0007502)2.77138563
63Hepatocellular carcinoma (HP:0001402)2.71499802
64Aortic dissection (HP:0002647)2.68724408
65Neonatal short-limb short stature (HP:0008921)2.66714504
66Glycosuria (HP:0003076)2.64664963
67Abnormality of urine glucose concentration (HP:0011016)2.64664963
68Soft skin (HP:0000977)2.59084269
69Cerebral edema (HP:0002181)2.52232318
70Malnutrition (HP:0004395)2.51198545
71Vomiting (HP:0002013)2.49190592
72Enlarged kidneys (HP:0000105)2.47937678
73Irritability (HP:0000737)2.44198101
74Type 1 muscle fiber predominance (HP:0003803)2.42971313
75Reduced antithrombin III activity (HP:0001976)2.41765043
76Wrist flexion contracture (HP:0001239)2.41521342
77Atrophic scars (HP:0001075)2.40594600
78Nemaline bodies (HP:0003798)2.40186568
79Spastic diplegia (HP:0001264)2.40017153
80Neonatal onset (HP:0003623)2.38190831
81Rickets (HP:0002748)2.35996203
82Abnormality of proline metabolism (HP:0010907)2.35628434
83Hydroxyprolinuria (HP:0003080)2.35628434
84Myocardial infarction (HP:0001658)2.34903042
85Aortic aneurysm (HP:0004942)2.34790025
86Sensorimotor neuropathy (HP:0007141)2.30080485
87Increased serum pyruvate (HP:0003542)2.27708536
88Hypokalemic alkalosis (HP:0001949)2.26784152
89Vascular tortuosity (HP:0004948)2.26524487
90Aplasia of the musculature (HP:0100854)2.26122588
91Septo-optic dysplasia (HP:0100842)2.25373813
92Late onset (HP:0003584)2.24307822
93Pterygium (HP:0001059)2.24277488
94Skin nodule (HP:0200036)2.23221821
95Systemic lupus erythematosus (HP:0002725)2.22501451
96Hypoglycemic seizures (HP:0002173)2.21744492
97Pancreatitis (HP:0001733)2.18829466
98Abnormal delivery (HP:0001787)2.17000792
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.16531277
100Mitral stenosis (HP:0001718)2.14659760
101Spontaneous abortion (HP:0005268)2.14225177
102Muscle fiber inclusion bodies (HP:0100299)2.13842243
103Increased circulating renin level (HP:0000848)2.12490512
104Abnormality of dentin (HP:0010299)2.11734468
105Hyperactive renin-angiotensin system (HP:0000841)2.10327564
106Abnormal enzyme/coenzyme activity (HP:0012379)2.08187810
107Renal cortical cysts (HP:0000803)2.05984422
108Microglossia (HP:0000171)2.05944137
109Stillbirth (HP:0003826)2.05760454
110Abnormal gallbladder morphology (HP:0012437)2.04659024
111Nephrolithiasis (HP:0000787)2.04249756
112Brushfield spots (HP:0001088)2.03181339
113Hypochromic microcytic anemia (HP:0004840)2.02918386
114Abnormality of glycolysis (HP:0004366)2.02157880
115Cholelithiasis (HP:0001081)2.01502666
116Abnormal urine output (HP:0012590)2.00677682
117Opisthotonus (HP:0002179)1.98824063
118Hypophosphatemic rickets (HP:0004912)1.98466733
119Acanthocytosis (HP:0001927)1.98204530
120Hip contracture (HP:0003273)1.97553124
121Metabolic alkalosis (HP:0200114)1.97353591
122Limited hip movement (HP:0008800)1.96972578
123Natal tooth (HP:0000695)1.96952535
124Short tibia (HP:0005736)1.96668734
125Abnormal gallbladder physiology (HP:0012438)1.96572219
126Cholecystitis (HP:0001082)1.96572219
127Confusion (HP:0001289)1.95578344
128Esophageal varix (HP:0002040)1.94889104
129Hyperphosphaturia (HP:0003109)1.94467365
130Exercise-induced muscle cramps (HP:0003710)1.94131030
131Entropion (HP:0000621)1.92675058
132Abnormality of renal excretion (HP:0011036)1.92092631
133Abnormality of vitamin metabolism (HP:0100508)1.91737172
134Type I transferrin isoform profile (HP:0003642)1.91439995
135Facial cleft (HP:0002006)1.91417123
136Nausea (HP:0002018)1.90417768
137Abnormal cartilage morphology (HP:0002763)1.89252271
138Abnormalities of placenta or umbilical cord (HP:0001194)1.89098692
139Delayed gross motor development (HP:0002194)1.88862506
140Wormian bones (HP:0002645)1.88364336
141Fragile skin (HP:0001030)1.88135053
142Shallow orbits (HP:0000586)1.85994849
143Knee flexion contracture (HP:0006380)1.85342768
144Absent septum pellucidum (HP:0001331)1.85093382
145Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84795935
146Arterial tortuosity (HP:0005116)1.84408234
147Cervical subluxation (HP:0003308)1.84356942
148Abnormality of alkaline phosphatase activity (HP:0004379)1.83688504
149Spondylolisthesis (HP:0003302)1.80864950
150Abnormality of carpal bone ossification (HP:0006257)1.75933911
151Renal tubular dysfunction (HP:0000124)1.75762453
152Coronal craniosynostosis (HP:0004440)1.70137724
153Bladder diverticulum (HP:0000015)1.69481313
154Abnormality of the septum pellucidum (HP:0007375)1.69027596
155Median cleft lip (HP:0000161)1.65616786
156Abnormal protein glycosylation (HP:0012346)1.64371028
157Abnormal glycosylation (HP:0012345)1.64371028
158Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64371028
159Abnormal protein N-linked glycosylation (HP:0012347)1.64371028
160Muscle stiffness (HP:0003552)1.63688689
161Breech presentation (HP:0001623)1.63672334
162Abnormality of the acetabulum (HP:0003170)1.62601816
163Methylmalonic acidemia (HP:0002912)1.62240986
164Abnormal urine phosphate concentration (HP:0012599)1.62070234
165Azoospermia (HP:0000027)1.61585941
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.60561814
167Bifid tongue (HP:0010297)1.58977605
168Neoplasm of head and neck (HP:0012288)1.58597082
169Esophageal neoplasm (HP:0100751)1.58597082
170Sparse eyelashes (HP:0000653)1.57449567
171Elbow flexion contracture (HP:0002987)1.56382979
172Renal Fanconi syndrome (HP:0001994)1.55802222
173Femoral bowing (HP:0002980)1.55098756

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.21352366
2FGFR43.97961060
3WNK33.78202495
4WNK43.62740680
5SIK13.54031924
6ERN13.49025854
7PBK3.19276303
8OXSR13.02321363
9EIF2AK32.80267131
10BUB12.72207797
11INSRR2.65319360
12ARAF2.46558347
13TAOK32.37265170
14STK162.33762369
15TTK2.25417742
16ERBB42.24543498
17MAP3K122.07983930
18MST1R2.02657613
19OBSCN1.93954821
20TNIK1.82704972
21MAP2K41.80165144
22MAPK111.73794165
23PTK61.71795513
24PKN21.70364872
25STK38L1.69296507
26MAP3K91.64010793
27SRPK11.62096470
28TIE11.55106875
29CDK91.54108768
30LIMK11.53739137
31PIK3CG1.53300658
32MST41.49881628
33MUSK1.44676911
34PDGFRA1.43605974
35NEK91.43298549
36STK241.42136459
37MAP3K71.40973345
38TRIB31.40756615
39ABL21.40150557
40EIF2AK11.39580977
41NEK61.38322659
42PINK11.37991751
43MOS1.35855398
44PAK21.35079674
45FRK1.34682437
46LATS21.32604671
47EPHB21.32186327
48BRAF1.29683627
49PAK41.29453023
50FLT31.27553661
51LATS11.27052019
52PLK31.24269264
53CDK81.23278776
54FGFR21.22185185
55NME11.22133322
56STK391.21443873
57NUAK11.16983214
58CDK191.16173085
59TYK21.15826568
60SGK2231.13951941
61SGK4941.13951941
62BMPR1B1.10529725
63DDR21.09472132
64CDC71.09394693
65SGK31.08072739
66STK31.07578753
67ILK1.07032684
68PRKAA21.05987509
69MAPK151.05671314
70ZAK1.04206754
71PLK11.03762443
72PDK41.03698854
73PDK31.03698854
74PIM21.02472765
75RAF11.01553825
76BRSK20.98952053
77JAK20.98111896
78KDR0.97995747
79GRK60.95072937
80MAP4K20.93497151
81CDK70.93168291
82MAP3K130.92121839
83DAPK20.90902784
84TGFBR10.89007766
85MAP2K30.88109907
86TGFBR20.87800396
87AURKA0.87293700
88SGK20.87258618
89DMPK0.85499998
90AKT30.83557408
91PRKCI0.82927604
92IRAK30.82725713
93RIPK10.80774354
94PRKCZ0.80698366
95MAP3K30.79264861
96MAPK40.79094463
97TBK10.78720460
98VRK10.77503710
99EPHB10.76294502
100MAP3K110.75809951
101PRKAA10.75428923
102GSK3A0.75390786
103DYRK1B0.73300143
104MAP3K140.72731999
105NTRK10.70607082
106PDPK10.69754247
107TRIM280.69423738
108AURKB0.69078579
109PHKG10.67029454
110PHKG20.67029454
111STK380.67012826
112MAPK120.65518768
113PRKACG0.64285633
114JAK10.63945082
115PTK20.63700836
116PLK40.63092644
117NEK20.62913802
118LMTK20.61359981
119VRK20.61018390
120ERBB20.60939997
121BRSK10.60541105
122PLK20.58943033
123PNCK0.58885296
124ROCK10.58808568
125LRRK20.57221935
126MAP2K60.56362440
127RPS6KB20.54279835
128NEK10.54056845
129CAMK2G0.52770404
130PDK20.52558113
131PRKCQ0.52530061
132MKNK20.52392189
133MET0.51448060
134PDK10.51180140
135AKT20.51129960
136WEE10.50379187
137CHEK20.49858360
138CHEK10.48677095
139RET0.48582872
140ROCK20.47808514
141CAMK1D0.47773435
142CSK0.47569254
143FER0.46161938
144PRKG10.45677401
145IGF1R0.45493781
146CDK60.45129217
147EPHA20.44754187
148MAP3K50.44265360
149KSR20.43720617
150TTN0.43453949
151DAPK30.43155919
152ERBB30.41940881
153CSNK2A20.41611075
154BCR0.41366038
155CASK0.40884625
156MYLK0.39268947
157FGFR30.37510028
158MAP2K10.36705648
159CSNK1G10.33774874
160KIT0.33772008
161MAPK70.32284567
162EPHA30.31840268
163EPHA40.31572352
164MAP3K100.30927941
165IKBKE0.30496794
166PRKCA0.27749412
167PRKCG0.26877376
168PRKG20.26626185
169CSF1R0.24485842
170MAP3K60.24293573
171FGFR10.22942861
172MTOR0.20985858
173PIK3CA0.20575410
174CAMK40.19764068
175MAP4K10.19717441
176MAP2K20.18891237
177IRAK20.18642867
178PAK30.18397137
179MAP3K10.17661185

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06177605
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.46219929
3Nitrogen metabolism_Homo sapiens_hsa009103.15156780
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01500013
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82116447
6Tryptophan metabolism_Homo sapiens_hsa003802.76257261
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74658561
8Arginine biosynthesis_Homo sapiens_hsa002202.71969616
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70294638
10Fatty acid degradation_Homo sapiens_hsa000712.69819114
11Butanoate metabolism_Homo sapiens_hsa006502.58943818
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.56020352
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49059032
14Propanoate metabolism_Homo sapiens_hsa006402.39658040
15Peroxisome_Homo sapiens_hsa041462.33249551
16Basal transcription factors_Homo sapiens_hsa030222.25350557
17Complement and coagulation cascades_Homo sapiens_hsa046102.18847275
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99444574
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99365031
20Fatty acid metabolism_Homo sapiens_hsa012121.97715285
21Ribosome_Homo sapiens_hsa030101.92179183
22PPAR signaling pathway_Homo sapiens_hsa033201.90084990
23Protein export_Homo sapiens_hsa030601.89648724
24beta-Alanine metabolism_Homo sapiens_hsa004101.87216428
25Proteasome_Homo sapiens_hsa030501.86368947
26Nucleotide excision repair_Homo sapiens_hsa034201.85985440
27Mismatch repair_Homo sapiens_hsa034301.83860604
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80737023
29Chemical carcinogenesis_Homo sapiens_hsa052041.78456924
30Histidine metabolism_Homo sapiens_hsa003401.77490601
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75418543
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.74482301
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65517634
34Pyruvate metabolism_Homo sapiens_hsa006201.63224431
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.61787286
36Retinol metabolism_Homo sapiens_hsa008301.61481846
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58833137
38Bile secretion_Homo sapiens_hsa049761.57864210
39Caffeine metabolism_Homo sapiens_hsa002321.55590356
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54947223
41Selenocompound metabolism_Homo sapiens_hsa004501.49880459
42Sulfur metabolism_Homo sapiens_hsa009201.48551205
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.47043919
44Homologous recombination_Homo sapiens_hsa034401.45911896
45Phenylalanine metabolism_Homo sapiens_hsa003601.42508854
46Fatty acid elongation_Homo sapiens_hsa000621.40638554
47Starch and sucrose metabolism_Homo sapiens_hsa005001.38575360
48Parkinsons disease_Homo sapiens_hsa050121.31908133
49ECM-receptor interaction_Homo sapiens_hsa045121.31436524
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31132188
51Carbon metabolism_Homo sapiens_hsa012001.29390375
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26344529
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.26181232
54Tyrosine metabolism_Homo sapiens_hsa003501.26086525
55Staphylococcus aureus infection_Homo sapiens_hsa051501.25994993
56Cell cycle_Homo sapiens_hsa041101.22716116
57RNA polymerase_Homo sapiens_hsa030201.20033307
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19998638
59Biosynthesis of amino acids_Homo sapiens_hsa012301.19579151
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17128148
61Folate biosynthesis_Homo sapiens_hsa007901.14876715
62Vitamin digestion and absorption_Homo sapiens_hsa049771.14826838
63ABC transporters_Homo sapiens_hsa020101.06581843
64Huntingtons disease_Homo sapiens_hsa050161.06491576
65Arginine and proline metabolism_Homo sapiens_hsa003301.04488226
66RNA degradation_Homo sapiens_hsa030180.99859176
67Steroid biosynthesis_Homo sapiens_hsa001000.97238850
68RNA transport_Homo sapiens_hsa030130.96272659
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.96244334
70Fat digestion and absorption_Homo sapiens_hsa049750.95080346
71p53 signaling pathway_Homo sapiens_hsa041150.94686332
72Lysine degradation_Homo sapiens_hsa003100.93625446
73DNA replication_Homo sapiens_hsa030300.92555707
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91783488
75Base excision repair_Homo sapiens_hsa034100.91711705
76Fanconi anemia pathway_Homo sapiens_hsa034600.90248096
77Glutathione metabolism_Homo sapiens_hsa004800.89225615
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86503369
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83879757
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83682342
81Sulfur relay system_Homo sapiens_hsa041220.82831610
82Glycerolipid metabolism_Homo sapiens_hsa005610.79640356
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77394990
84Alzheimers disease_Homo sapiens_hsa050100.76965405
85Oocyte meiosis_Homo sapiens_hsa041140.76102215
86TGF-beta signaling pathway_Homo sapiens_hsa043500.72567866
87Vitamin B6 metabolism_Homo sapiens_hsa007500.72131883
88Cardiac muscle contraction_Homo sapiens_hsa042600.68539159
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66645380
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66059575
91Circadian rhythm_Homo sapiens_hsa047100.65606306
92Pentose phosphate pathway_Homo sapiens_hsa000300.65010999
93Pyrimidine metabolism_Homo sapiens_hsa002400.60052145
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59377857
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57310086
96One carbon pool by folate_Homo sapiens_hsa006700.56862590
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56654343
98N-Glycan biosynthesis_Homo sapiens_hsa005100.54630703
99Metabolic pathways_Homo sapiens_hsa011000.52027360
100Focal adhesion_Homo sapiens_hsa045100.48817841
101Fatty acid biosynthesis_Homo sapiens_hsa000610.47409797
102Purine metabolism_Homo sapiens_hsa002300.46913053
103Non-homologous end-joining_Homo sapiens_hsa034500.44780893
104Fructose and mannose metabolism_Homo sapiens_hsa000510.39154205
105Galactose metabolism_Homo sapiens_hsa000520.28593069
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26363724
107Insulin resistance_Homo sapiens_hsa049310.23436107
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.20694226
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18617722
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18259367
111Prion diseases_Homo sapiens_hsa050200.16296773
112Linoleic acid metabolism_Homo sapiens_hsa005910.15287767
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.11303689
114Glucagon signaling pathway_Homo sapiens_hsa049220.08241215
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02256573
116AMPK signaling pathway_Homo sapiens_hsa041520.01843825
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.01682570
118Renin-angiotensin system_Homo sapiens_hsa046140.01099978
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.2203529
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2059909
121Oxidative phosphorylation_Homo sapiens_hsa00190-0.1998051
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1977336
123Hepatitis C_Homo sapiens_hsa05160-0.1750795
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1498357
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1337390
126Insulin signaling pathway_Homo sapiens_hsa04910-0.1312119
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1222990
128Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1182134
129Lysosome_Homo sapiens_hsa04142-0.1034786
130Regulation of autophagy_Homo sapiens_hsa04140-0.0863190
131Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0826221
132Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0698038
133Mineral absorption_Homo sapiens_hsa04978-0.0438297
134Other glycan degradation_Homo sapiens_hsa00511-0.0344010
135Protein digestion and absorption_Homo sapiens_hsa04974-0.0218287
136Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0123241

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