SUGP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.48507582
2sperm motility (GO:0030317)5.36594925
3piRNA metabolic process (GO:0034587)5.20728294
4acrosome reaction (GO:0007340)5.08891004
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.95821115
6fusion of sperm to egg plasma membrane (GO:0007342)4.75578149
7acrosome assembly (GO:0001675)4.71250730
8axonemal dynein complex assembly (GO:0070286)4.68825313
9synaptic vesicle maturation (GO:0016188)4.51534691
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.48535324
11locomotory exploration behavior (GO:0035641)4.43401954
12motile cilium assembly (GO:0044458)4.42067500
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.36190025
14histone H3-K36 demethylation (GO:0070544)4.30204697
15male meiosis (GO:0007140)4.29732999
16epithelial cilium movement (GO:0003351)4.25642604
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20102030
18regulation of NFAT protein import into nucleus (GO:0051532)4.15807702
19synaptonemal complex organization (GO:0070193)4.12211275
20plasma membrane fusion (GO:0045026)4.08934377
21spermatid development (GO:0007286)4.06401612
22sperm-egg recognition (GO:0035036)4.03573702
23histone H3-K9 demethylation (GO:0033169)3.96263647
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.94875972
25vocalization behavior (GO:0071625)3.92873075
26negative regulation of erythrocyte differentiation (GO:0045647)3.90177338
27positive regulation of synapse maturation (GO:0090129)3.89225167
28synaptonemal complex assembly (GO:0007130)3.89013908
29regulation of cilium movement (GO:0003352)3.88388141
30cilium movement (GO:0003341)3.88273708
31regulation of glutamate receptor signaling pathway (GO:1900449)3.83951812
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.81403648
33glucocorticoid receptor signaling pathway (GO:0042921)3.79836021
34protein localization to synapse (GO:0035418)3.73980447
35calcium ion-dependent exocytosis (GO:0017156)3.73175137
36cell-cell recognition (GO:0009988)3.72080815
37synaptic vesicle exocytosis (GO:0016079)3.68689791
38DNA synthesis involved in DNA repair (GO:0000731)3.67740100
39binding of sperm to zona pellucida (GO:0007339)3.67382912
40histone H3-K4 trimethylation (GO:0080182)3.67255412
41negative regulation of histone methylation (GO:0031061)3.66611685
42multicellular organism reproduction (GO:0032504)3.65494206
43regulation of histone H3-K27 methylation (GO:0061085)3.61530093
44layer formation in cerebral cortex (GO:0021819)3.59582611
45DNA methylation involved in gamete generation (GO:0043046)3.54324530
46mitotic chromosome condensation (GO:0007076)3.51372500
47cell migration in hindbrain (GO:0021535)3.50795055
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.50687080
49membrane depolarization during action potential (GO:0086010)3.50174571
50response to pheromone (GO:0019236)3.46299196
51cerebellar granule cell differentiation (GO:0021707)3.45192197
52histone lysine demethylation (GO:0070076)3.43265763
53regulation of synapse structural plasticity (GO:0051823)3.42480546
54regulation of synaptic vesicle exocytosis (GO:2000300)3.39595773
55nuclear pore complex assembly (GO:0051292)3.39543879
56negative regulation of inclusion body assembly (GO:0090084)3.35671536
57exploration behavior (GO:0035640)3.35096688
58synaptic transmission, glutamatergic (GO:0035249)3.34322704
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.30585323
60regulation of neuronal synaptic plasticity (GO:0048168)3.29979964
61glutamate secretion (GO:0014047)3.28911809
62mannose metabolic process (GO:0006013)3.28654343
63regulation of long-term neuronal synaptic plasticity (GO:0048169)3.27343642
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26889526
65regulation of synaptic vesicle transport (GO:1902803)3.26534351
66ventricular system development (GO:0021591)3.24728179
67neurotransmitter secretion (GO:0007269)3.22961096
68histone demethylation (GO:0016577)3.22766283
69positive regulation of gene expression, epigenetic (GO:0045815)3.22285022
70regulation of RNA export from nucleus (GO:0046831)3.18499903
71nucleosome disassembly (GO:0006337)3.17183209
72protein-DNA complex disassembly (GO:0032986)3.17183209
73regulation of synapse maturation (GO:0090128)3.14150873
74glutamate receptor signaling pathway (GO:0007215)3.12136464
75cell wall macromolecule metabolic process (GO:0044036)3.11682994
76cell wall macromolecule catabolic process (GO:0016998)3.11682994
77dendritic spine morphogenesis (GO:0060997)3.09151821
78DNA unwinding involved in DNA replication (GO:0006268)3.08732989
79cerebellar Purkinje cell differentiation (GO:0021702)3.08359716
80histone deubiquitination (GO:0016578)3.07249777
81histone lysine methylation (GO:0034968)3.06512623
82negative regulation of organelle assembly (GO:1902116)3.06089251
83positive regulation of CREB transcription factor activity (GO:0032793)3.05675769
84histone H3-K9 modification (GO:0061647)3.03721962
85histone H4 deacetylation (GO:0070933)3.03545987
86regulation of nucleobase-containing compound transport (GO:0032239)3.03139268
87synaptic vesicle endocytosis (GO:0048488)3.02613080
88histone H3-K9 methylation (GO:0051567)3.02569835
89DNA topological change (GO:0006265)3.02219301
90mitochondrion transport along microtubule (GO:0047497)3.00536695
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00536695
92protein localization to cilium (GO:0061512)2.98369084
93corticosteroid receptor signaling pathway (GO:0031958)2.96781064
94male meiosis I (GO:0007141)2.96736369
95regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.96152096
96reproduction (GO:0000003)2.95945982
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93907351
98positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.93395558
99regulation of ARF GTPase activity (GO:0032312)2.92840543
100establishment of mitochondrion localization (GO:0051654)2.92359259
101postsynaptic membrane organization (GO:0001941)2.91504199
102histone H3-K4 methylation (GO:0051568)2.89720149
103neuromuscular process controlling balance (GO:0050885)2.89679694
104positive regulation of membrane potential (GO:0045838)2.88860323
105dosage compensation (GO:0007549)2.88189831
106regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88165786
107cellular potassium ion homeostasis (GO:0030007)2.87883352
108sister chromatid segregation (GO:0000819)2.87786534
109long-term memory (GO:0007616)2.85821188
110neuron-neuron synaptic transmission (GO:0007270)2.85375689
111protein demethylation (GO:0006482)2.85231732
112protein dealkylation (GO:0008214)2.85231732
113neuron cell-cell adhesion (GO:0007158)2.85152477
114establishment of nucleus localization (GO:0040023)2.83572979
115regulation of ARF protein signal transduction (GO:0032012)2.83357416
116histone H4-K16 acetylation (GO:0043984)2.83272014
117prepulse inhibition (GO:0060134)2.83182502
118neuronal ion channel clustering (GO:0045161)2.80330623
119positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.78864528
120sodium ion export (GO:0071436)2.78694110
121left/right pattern formation (GO:0060972)2.78578083
122mitotic sister chromatid cohesion (GO:0007064)2.78199021
123spermatogenesis (GO:0007283)2.77510811
124male gamete generation (GO:0048232)2.76713665
125regulation of postsynaptic membrane potential (GO:0060078)2.76382757
126membrane depolarization (GO:0051899)2.75008356
127regulation of microtubule-based movement (GO:0060632)2.74084818
128L-amino acid import (GO:0043092)2.73966213
129peptidyl-lysine dimethylation (GO:0018027)2.73711065
130negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.72785828
131chromosome organization involved in meiosis (GO:0070192)2.72353806
132stress granule assembly (GO:0034063)2.70942743
133cell communication by electrical coupling (GO:0010644)2.70893525
134spliceosomal tri-snRNP complex assembly (GO:0000244)2.69992511
135neuronal action potential propagation (GO:0019227)2.69110258
136histone H3 deacetylation (GO:0070932)2.69040802
137negative regulation of cell killing (GO:0031342)2.68947198
138negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68947198
139dendrite morphogenesis (GO:0048813)2.68294412
140peptidyl-threonine phosphorylation (GO:0018107)2.67564163
141establishment of spindle orientation (GO:0051294)2.66980952
142positive regulation of synaptic transmission, GABAergic (GO:0032230)2.66940504
143mitotic sister chromatid segregation (GO:0000070)2.66908108
144nuclear pore organization (GO:0006999)2.66788475
145neurotransmitter-gated ion channel clustering (GO:0072578)2.66528492
146regulation of histone methylation (GO:0031060)2.66272854
147intracellular estrogen receptor signaling pathway (GO:0030520)2.66180076
148central nervous system projection neuron axonogenesis (GO:0021952)2.63914208
149histone methylation (GO:0016571)2.63708275
150cell recognition (GO:0008037)2.62804457
151sperm capacitation (GO:0048240)2.62238641
152regulation of histone H3-K9 methylation (GO:0051570)2.61576457
153neural tube development (GO:0021915)2.60235635
154G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60167576
155regulation of mitotic spindle organization (GO:0060236)2.58524329
156axon ensheathment in central nervous system (GO:0032291)2.58442953
157central nervous system myelination (GO:0022010)2.58442953
158positive regulation of dendritic spine morphogenesis (GO:0061003)2.58060855
159striatum development (GO:0021756)2.57920151
160peptidyl-lysine methylation (GO:0018022)2.57595743
161gamma-aminobutyric acid transport (GO:0015812)2.57239751
162cell differentiation in hindbrain (GO:0021533)2.56910244
163visual behavior (GO:0007632)2.56597649
164negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55562923
165germ cell development (GO:0007281)2.55453773
166peptidyl-lysine trimethylation (GO:0018023)2.55220437
167DNA alkylation (GO:0006305)2.53931189
168DNA methylation (GO:0006306)2.53931189
169chromosome condensation (GO:0030261)2.53352932
170establishment of spindle localization (GO:0051293)2.53186861
171single fertilization (GO:0007338)2.52901604
172meiotic nuclear division (GO:0007126)2.52824116
173negative regulation of gene expression, epigenetic (GO:0045814)2.52530497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.26105279
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.69133191
3E2F7_22180533_ChIP-Seq_HELA_Human3.59470561
4MYC_22102868_ChIP-Seq_BL_Human3.52893157
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.51162056
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.19169556
7VDR_21846776_ChIP-Seq_THP-1_Human3.04099846
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.86051887
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.85713575
10DROSHA_22980978_ChIP-Seq_HELA_Human2.83430870
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68895059
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.68794644
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56604583
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.55005466
15GBX2_23144817_ChIP-Seq_PC3_Human2.53789177
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.50217442
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39624939
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.38757691
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.24640148
20LXR_22292898_ChIP-Seq_THP-1_Human2.19325269
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13037166
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.06115135
23KDM2B_26808549_Chip-Seq_JURKAT_Human2.04565102
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96460142
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92807113
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88113377
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.87715790
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.83562287
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.82059964
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81943425
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81906261
32ZNF274_21170338_ChIP-Seq_K562_Hela1.80607649
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76770454
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75987594
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75890502
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.75832369
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.68913655
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67194861
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.63972228
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.61435081
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60469560
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58077476
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.57217280
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56562119
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55704975
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55704975
47CREB1_26743006_Chip-Seq_LNCaP_Human1.54425736
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54374217
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53820429
50PKCTHETA_26484144_Chip-Seq_BREAST_Human1.53760052
51P68_20966046_ChIP-Seq_HELA_Human1.52395140
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.51189322
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46625542
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46083314
55CIITA_25753668_ChIP-Seq_RAJI_Human1.45746357
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45353142
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43954276
58WDR5_24793694_ChIP-Seq_LNCAP_Human1.34833542
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.34666336
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33132135
61VDR_24763502_ChIP-Seq_THP-1_Human1.32226492
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28939878
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28616762
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28013336
65MAF_26560356_Chip-Seq_TH2_Human1.27630793
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27085364
67ELK4_26923725_Chip-Seq_MESODERM_Mouse1.26328110
68UTX_26944678_Chip-Seq_JUKART_Human1.23810190
69MAF_26560356_Chip-Seq_TH1_Human1.23646754
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.22130948
71SMAD4_21799915_ChIP-Seq_A2780_Human1.22092899
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20565287
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18524956
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17749149
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17662655
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17453201
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17192025
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16824452
79NCOR1_26117541_ChIP-Seq_K562_Human1.16423354
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15707802
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15707802
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15414998
83RNF2_27304074_Chip-Seq_NSC_Mouse1.14812557
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13322348
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.13303924
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12723954
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12386688
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11047494
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10716891
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.09700586
91TCF4_23295773_ChIP-Seq_U87_Human1.09438245
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.09325736
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08313471
94RACK7_27058665_Chip-Seq_MCF-7_Human1.06860132
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06334041
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05480335
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03185480
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02024509
99SMAD3_21741376_ChIP-Seq_ESCs_Human1.01426050
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01171164
101* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01123807
102SCL_19346495_ChIP-Seq_HPC-7_Human1.01037085
103TET1_21490601_ChIP-Seq_MESCs_Mouse1.00420270
104KDM2B_26808549_Chip-Seq_K562_Human0.99718073
105ELF1_20517297_ChIP-Seq_JURKAT_Human0.98939802
106RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98014718
107CTCF_27219007_Chip-Seq_Bcells_Human0.97934586
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97376419
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.96729621
110AR_19668381_ChIP-Seq_PC3_Human0.96206004
111TET1_21451524_ChIP-Seq_MESCs_Mouse0.95986803
112RUNX1_27514584_Chip-Seq_MCF-7_Human0.95415107
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94686760
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94120993
115OCT4_19829295_ChIP-Seq_ESCs_Human0.93685240
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93370736
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93224125
118TP53_23651856_ChIP-Seq_MEFs_Mouse0.93005348
119STAT3_23295773_ChIP-Seq_U87_Human0.92417383
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91258774
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90855681
122TCF7_22412390_ChIP-Seq_EML_Mouse0.90767208
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90528260
124CBP_20019798_ChIP-Seq_JUKART_Human0.90528260
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90514458
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.90402450
127HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89615798
128SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89341708
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88665861
130KDM2B_26808549_Chip-Seq_DND41_Human0.87093581
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87072042
132AR_21572438_ChIP-Seq_LNCaP_Human0.86077676
133SMC4_20622854_ChIP-Seq_HELA_Human0.85883221
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85858079
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85845668
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85627749
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85332000
138KLF4_19829295_ChIP-Seq_ESCs_Human0.85042889
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85028182
140WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84909055
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.84032448
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83116729
143AR_25329375_ChIP-Seq_VCAP_Human0.82977555
144TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82428896
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81645871
146CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79720314
147PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77256465
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77239299
149FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77116749
150KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76855542
151TAF15_26573619_Chip-Seq_HEK293_Human0.76272415
152STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76226105
153SMAD3_21741376_ChIP-Seq_EPCs_Human0.75763741
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74775171
155KDM2B_26808549_Chip-Seq_REH_Human0.74375999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.14724106
2MP0005410_abnormal_fertilization4.90180480
3MP0003880_abnormal_central_pattern4.65099306
4MP0005423_abnormal_somatic_nervous4.37182682
5MP0003635_abnormal_synaptic_transmissio3.18160806
6MP0000569_abnormal_digit_pigmentation3.05592696
7MP0008877_abnormal_DNA_methylation2.63884437
8MP0009046_muscle_twitch2.62682303
9MP0002063_abnormal_learning/memory/cond2.55117593
10MP0004270_analgesia2.53625328
11MP0003698_abnormal_male_reproductive2.47294344
12MP0009745_abnormal_behavioral_response2.41642019
13MP0005076_abnormal_cell_differentiation2.30347595
14MP0008057_abnormal_DNA_replication2.24328827
15MP0009780_abnormal_chondrocyte_physiolo2.20098332
16MP0002064_seizures2.15361457
17MP0002396_abnormal_hematopoietic_system2.09150398
18MP0009278_abnormal_bone_marrow2.05793007
19MP0003123_paternal_imprinting2.05309481
20MP0002572_abnormal_emotion/affect_behav2.02933572
21MP0001929_abnormal_gametogenesis1.98725093
22MP0003705_abnormal_hypodermis_morpholog1.95091717
23MP0001968_abnormal_touch/_nociception1.94194783
24MP0001486_abnormal_startle_reflex1.92265943
25MP0001984_abnormal_olfaction1.91882813
26MP0002009_preneoplasia1.90872334
27MP0008569_lethality_at_weaning1.84415211
28MP0002272_abnormal_nervous_system1.79912666
29MP0002249_abnormal_larynx_morphology1.78191182
30MP0004811_abnormal_neuron_physiology1.77254500
31MP0002734_abnormal_mechanical_nocicepti1.75440531
32MP0005645_abnormal_hypothalamus_physiol1.73129547
33MP0003111_abnormal_nucleus_morphology1.72955144
34MP0000778_abnormal_nervous_system1.70047732
35MP0002822_catalepsy1.62134238
36MP0001348_abnormal_lacrimal_gland1.61189794
37MP0004185_abnormal_adipocyte_glucose1.58693931
38MP0003787_abnormal_imprinting1.57465924
39MP0009672_abnormal_birth_weight1.55333255
40MP0006276_abnormal_autonomic_nervous1.54904804
41MP0002067_abnormal_sensory_capabilities1.52771966
42MP0002184_abnormal_innervation1.47305175
43MP0002735_abnormal_chemical_nociception1.45373893
44MP0002557_abnormal_social/conspecific_i1.44190654
45MP0002909_abnormal_adrenal_gland1.43662612
46MP0001440_abnormal_grooming_behavior1.43405099
47MP0002210_abnormal_sex_determination1.42846359
48MP0000955_abnormal_spinal_cord1.41122199
49MP0004924_abnormal_behavior1.38524935
50MP0005386_behavior/neurological_phenoty1.38524935
51MP0003690_abnormal_glial_cell1.34121319
52MP0004130_abnormal_muscle_cell1.33074651
53MP0002653_abnormal_ependyma_morphology1.33018109
54MP0008995_early_reproductive_senescence1.32133307
55MP0010094_abnormal_chromosome_stability1.30886024
56MP0003122_maternal_imprinting1.30632777
57MP0008961_abnormal_basal_metabolism1.29874543
58MP0004145_abnormal_muscle_electrophysio1.29191948
59MP0002161_abnormal_fertility/fecundity1.26681088
60MP0001188_hyperpigmentation1.25360034
61MP0002733_abnormal_thermal_nociception1.24759830
62MP0002882_abnormal_neuron_morphology1.24140036
63MP0001501_abnormal_sleep_pattern1.22313317
64MP0003115_abnormal_respiratory_system1.22186793
65MP0005646_abnormal_pituitary_gland1.21522435
66MP0002736_abnormal_nociception_after1.21255575
67MP0003879_abnormal_hair_cell1.20473724
68MP0001970_abnormal_pain_threshold1.18579823
69MP0001502_abnormal_circadian_rhythm1.17364182
70MP0003646_muscle_fatigue1.16747438
71MP0003077_abnormal_cell_cycle1.13869283
72MP0002152_abnormal_brain_morphology1.12530630
73MP0003634_abnormal_glial_cell1.12491310
74MP0005551_abnormal_eye_electrophysiolog1.11371069
75MP0001145_abnormal_male_reproductive1.11127757
76MP0000751_myopathy1.08345163
77MP0002066_abnormal_motor_capabilities/c1.05530906
78MP0006292_abnormal_olfactory_placode1.05320287
79MP0000566_synostosis1.04661859
80MP0009703_decreased_birth_body1.03317694
81MP0008007_abnormal_cellular_replicative1.00492625
82MP0003938_abnormal_ear_development1.00237540
83MP0000350_abnormal_cell_proliferation0.98454970
84MP0001730_embryonic_growth_arrest0.98426310
85MP0003890_abnormal_embryonic-extraembry0.97941758
86MP0004233_abnormal_muscle_weight0.95855459
87MP0003763_abnormal_thymus_physiology0.95332884
88MP0000015_abnormal_ear_pigmentation0.95117312
89MP0002234_abnormal_pharynx_morphology0.95007587
90MP0000653_abnormal_sex_gland0.94396056
91MP0005666_abnormal_adipose_tissue0.92671669
92MP0005409_darkened_coat_color0.91430518
93MP0003633_abnormal_nervous_system0.90552424
94MP0003121_genomic_imprinting0.90091016
95MP0002081_perinatal_lethality0.90031366
96MP0000703_abnormal_thymus_morphology0.88551306
97MP0005174_abnormal_tail_pigmentation0.88370071
98MP0002089_abnormal_postnatal_growth/wei0.88358571
99MP0003329_amyloid_beta_deposits0.88252287
100MP0004885_abnormal_endolymph0.88092406
101MP0001346_abnormal_lacrimal_gland0.87960039
102MP0006072_abnormal_retinal_apoptosis0.86550172
103MP0010770_preweaning_lethality0.86476936
104MP0002082_postnatal_lethality0.86476936
105MP0001943_abnormal_respiration0.86285869
106MP0002102_abnormal_ear_morphology0.86032596
107MP0004808_abnormal_hematopoietic_stem0.85482018
108MP0010768_mortality/aging0.85478646
109MP0002114_abnormal_axial_skeleton0.85131556
110MP0001177_atelectasis0.85098614
111MP0000631_abnormal_neuroendocrine_gland0.83543758
112MP0000733_abnormal_muscle_development0.83378642
113MP0002229_neurodegeneration0.83316719
114MP0004197_abnormal_fetal_growth/weight/0.83115756
115MP0000428_abnormal_craniofacial_morphol0.82208969
116MP0008872_abnormal_physiological_respon0.81462250
117MP0003385_abnormal_body_wall0.81454160
118MP0002116_abnormal_craniofacial_bone0.81125629
119MP0003632_abnormal_nervous_system0.81113661
120MP0003948_abnormal_gas_homeostasis0.79828844
121MP0003984_embryonic_growth_retardation0.79419586
122MP0003861_abnormal_nervous_system0.78490360
123MP0003172_abnormal_lysosome_physiology0.78039057
124MP0004134_abnormal_chest_morphology0.77600676
125MP0005380_embryogenesis_phenotype0.76471724
126MP0001672_abnormal_embryogenesis/_devel0.76471724
127MP0010307_abnormal_tumor_latency0.76461051
128MP0010630_abnormal_cardiac_muscle0.76197324
129MP0005253_abnormal_eye_physiology0.75785994
130MP0003631_nervous_system_phenotype0.75727912
131MP0004858_abnormal_nervous_system0.73896368
132MP0001299_abnormal_eye_distance/0.72754827
133MP0004142_abnormal_muscle_tone0.72231394
134MP0005499_abnormal_olfactory_system0.71782438
135MP0005394_taste/olfaction_phenotype0.71782438
136MP0002638_abnormal_pupillary_reflex0.69702489
137MP0004742_abnormal_vestibular_system0.68380597
138MP0003183_abnormal_peptide_metabolism0.68371733
139MP0001986_abnormal_taste_sensitivity0.67924048
140MP0002160_abnormal_reproductive_system0.67274992
141MP0002752_abnormal_somatic_nervous0.67199332
142MP0003283_abnormal_digestive_organ0.66429890
143MP0002069_abnormal_eating/drinking_beha0.65584717
144MP0001905_abnormal_dopamine_level0.57121678
145MP0001529_abnormal_vocalization0.56299386
146MP0010769_abnormal_survival0.55844739
147MP0008058_abnormal_DNA_repair0.55788185

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.80760095
2Absent/shortened dynein arms (HP:0200106)6.80760095
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.64653678
4Abnormal respiratory epithelium morphology (HP:0012253)4.56810234
5Abnormal respiratory motile cilium morphology (HP:0005938)4.56810234
6Abnormal respiratory motile cilium physiology (HP:0012261)4.49250368
7Abnormality of the lower motor neuron (HP:0002366)3.93490243
8Focal motor seizures (HP:0011153)3.86933030
9Abnormal ciliary motility (HP:0012262)3.80667641
10Rhinitis (HP:0012384)3.65360259
11Myokymia (HP:0002411)3.60534841
12Focal seizures (HP:0007359)3.41326698
13Abnormality of the fingertips (HP:0001211)3.41201283
14Amyotrophic lateral sclerosis (HP:0007354)3.40970709
15Obstructive sleep apnea (HP:0002870)3.20132919
16Progressive cerebellar ataxia (HP:0002073)3.15807655
17Infertility (HP:0000789)3.15542438
18Visual hallucinations (HP:0002367)3.11818522
19Nasal polyposis (HP:0100582)3.08974006
20Heterotopia (HP:0002282)2.93827491
21Hyperacusis (HP:0010780)2.93812428
22Gaze-evoked nystagmus (HP:0000640)2.87614778
2311 pairs of ribs (HP:0000878)2.85972199
24Supranuclear gaze palsy (HP:0000605)2.74940797
25Epileptic encephalopathy (HP:0200134)2.73458776
26Nephronophthisis (HP:0000090)2.73280015
27Febrile seizures (HP:0002373)2.72723350
28Turricephaly (HP:0000262)2.56518532
29Macroorchidism (HP:0000053)2.51635256
30Ankle clonus (HP:0011448)2.51425096
31Deep palmar crease (HP:0006191)2.49724880
32Insomnia (HP:0100785)2.49337650
33Annular pancreas (HP:0001734)2.49177416
34Chronic bronchitis (HP:0004469)2.48180292
35Abnormality of ocular smooth pursuit (HP:0000617)2.46820013
36Trigonocephaly (HP:0000243)2.40949324
37Abnormality of the nasal mucosa (HP:0000433)2.39684807
38Metaphyseal cupping (HP:0003021)2.39022305
39Broad palm (HP:0001169)2.35236648
40Abnormality of cochlea (HP:0000375)2.34438626
41Papilledema (HP:0001085)2.33402617
42Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.32698030
43Elfin facies (HP:0004428)2.32362188
44Bronchomalacia (HP:0002780)2.31265747
45Broad-based gait (HP:0002136)2.29402871
46Bowel incontinence (HP:0002607)2.28503408
47Impaired smooth pursuit (HP:0007772)2.26018369
48Postural instability (HP:0002172)2.25508490
49Hemiparesis (HP:0001269)2.24556432
50Broad distal phalanx of finger (HP:0009836)2.22912705
51Morphological abnormality of the inner ear (HP:0011390)2.22126457
52Shallow orbits (HP:0000586)2.20811009
53Long eyelashes (HP:0000527)2.20606187
54Bronchiectasis (HP:0002110)2.18586583
55Genetic anticipation (HP:0003743)2.17679190
56Depression (HP:0000716)2.15435719
57Renovascular hypertension (HP:0100817)2.14887017
58Poor eye contact (HP:0000817)2.14267402
59Mutism (HP:0002300)2.14035397
60Abnormality of chromosome segregation (HP:0002916)2.12941308
61Broad face (HP:0000283)2.11434489
62Urinary urgency (HP:0000012)2.10259876
63Vertebral arch anomaly (HP:0008438)2.08677717
64Recurrent otitis media (HP:0000403)2.08561117
65Pointed chin (HP:0000307)2.07963042
66Disproportionate tall stature (HP:0001519)2.07765152
67Abnormality of the calcaneus (HP:0008364)2.06335025
68Truncal ataxia (HP:0002078)2.05911934
69Polyphagia (HP:0002591)2.05729115
70Impaired vibration sensation in the lower limbs (HP:0002166)2.05686674
71Missing ribs (HP:0000921)2.03390107
72Truncal obesity (HP:0001956)2.02987382
73Abnormal large intestine physiology (HP:0012700)2.02243539
74Urinary bladder sphincter dysfunction (HP:0002839)2.01143273
75Abnormal eating behavior (HP:0100738)2.00488851
76Thin ribs (HP:0000883)1.99773934
77Hypoplasia of the brainstem (HP:0002365)1.98909027
78Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98909027
79Precocious puberty (HP:0000826)1.97493118
80Absent frontal sinuses (HP:0002688)1.95751225
81Peripheral hypomyelination (HP:0007182)1.95737586
82Attention deficit hyperactivity disorder (HP:0007018)1.95731291
83High anterior hairline (HP:0009890)1.95219652
84Dislocated radial head (HP:0003083)1.95008624
85Acute lymphatic leukemia (HP:0006721)1.94883224
86Bronchitis (HP:0012387)1.90010970
87Diplopia (HP:0000651)1.89819091
88Abnormality of binocular vision (HP:0011514)1.89819091
89Abnormality of the renal medulla (HP:0100957)1.88804201
90Action tremor (HP:0002345)1.87307789
91Abnormality of the thoracic spine (HP:0100711)1.86412129
92Cerebral aneurysm (HP:0004944)1.86024076
93Tracheomalacia (HP:0002779)1.85277901
94Neuronal loss in central nervous system (HP:0002529)1.84611948
95Sandal gap (HP:0001852)1.84452821
96Inappropriate behavior (HP:0000719)1.84397612
97Abnormal social behavior (HP:0012433)1.84335173
98Impaired social interactions (HP:0000735)1.84335173
99Lissencephaly (HP:0001339)1.84246669
100Protruding tongue (HP:0010808)1.83795364
101Bradykinesia (HP:0002067)1.83735296
102Scanning speech (HP:0002168)1.83590341
103Neurofibrillary tangles (HP:0002185)1.83552380
104Megalencephaly (HP:0001355)1.81707318
105Medial flaring of the eyebrow (HP:0010747)1.81345788
106Dysmetric saccades (HP:0000641)1.80710379
107Increased nuchal translucency (HP:0010880)1.80535173
108Bundle branch block (HP:0011710)1.80473488
109Overriding aorta (HP:0002623)1.80139004
110Progressive inability to walk (HP:0002505)1.79015731
111Absent speech (HP:0001344)1.78946282
112Abnormality of the radial head (HP:0003995)1.78307897
113Megalocornea (HP:0000485)1.78028117
114Deeply set eye (HP:0000490)1.76531016
115Dysdiadochokinesis (HP:0002075)1.76292176
116Neonatal hypoglycemia (HP:0001998)1.76270652
117Tented upper lip vermilion (HP:0010804)1.75236306
118Ankyloglossia (HP:0010296)1.75141659
119Drooling (HP:0002307)1.75093946
120Excessive salivation (HP:0003781)1.75093946
121Truncus arteriosus (HP:0001660)1.75041142
122Patellar dislocation (HP:0002999)1.74885696
123Spina bifida occulta (HP:0003298)1.73998400
124Cerebral inclusion bodies (HP:0100314)1.73980370
125Central scotoma (HP:0000603)1.73730106
126Sporadic (HP:0003745)1.73638658
127Spastic gait (HP:0002064)1.73346080
128Slow saccadic eye movements (HP:0000514)1.71766892
129Intellectual disability, profound (HP:0002187)1.71635385
130Large eyes (HP:0001090)1.70896440
131Sacral dimple (HP:0000960)1.70811597
132Pseudobulbar signs (HP:0002200)1.70251236
133Broad finger (HP:0001500)1.69701215
134Facial hemangioma (HP:0000329)1.69504778
135Narrow palate (HP:0000189)1.69174511
136Gait imbalance (HP:0002141)1.69022369
137Cortical dysplasia (HP:0002539)1.68971595
138Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68748717
139Broad phalanges of the hand (HP:0009768)1.68514000
140Impaired vibratory sensation (HP:0002495)1.68432413
141Inability to walk (HP:0002540)1.67966204
142Abnormality of the aortic arch (HP:0012303)1.67683621
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.67552777
144Status epilepticus (HP:0002133)1.65988344
145Autism (HP:0000717)1.65245570
146Obsessive-compulsive behavior (HP:0000722)1.64749585
147Renal duplication (HP:0000075)1.63589957
148Flat cornea (HP:0007720)1.63317118
149Hammertoe (HP:0001765)1.63148617
150Absence seizures (HP:0002121)1.62858337
151Gonadotropin excess (HP:0000837)1.62697303
152Supernumerary ribs (HP:0005815)1.62492686
153Pachygyria (HP:0001302)1.61941318
154Relative macrocephaly (HP:0004482)1.61686171
155Stereotypic behavior (HP:0000733)1.61014386
156Limb ataxia (HP:0002070)1.60336237
157Acute myeloid leukemia (HP:0004808)1.59407879
158Clonus (HP:0002169)1.58681166
159Neoplasm of the heart (HP:0100544)1.55080396
160Choroideremia (HP:0001139)1.54840267
161Spinal canal stenosis (HP:0003416)1.54687088
162Dyschromatopsia (HP:0007641)1.53843041
163Lower limb muscle weakness (HP:0007340)1.53697243
164Atonic seizures (HP:0010819)1.52998446
165Abnormality of saccadic eye movements (HP:0000570)1.52238129
166Hemiplegia (HP:0002301)1.51908226
167Generalized tonic-clonic seizures (HP:0002069)1.51874901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.11761294
2PDK44.11761294
3TRIB33.87834792
4MARK13.80689203
5PRKD33.48478267
6NTRK32.94474883
7MAP3K92.36643451
8MAP3K42.27486924
9ICK2.25905542
10PDK22.24052067
11PNCK2.23036697
12NTRK22.20932413
13EPHA42.19851129
14SIK22.12048019
15CAMKK12.03290772
16MINK12.02698321
17PAK61.99033260
18STK381.93097960
19TNIK1.86525493
20MAP2K71.85837642
21SMG11.84827377
22DAPK21.70564361
23CAMK1G1.66627942
24TESK11.61513550
25FGFR41.52947744
26PTK2B1.43700340
27MAP2K61.40873530
28RIPK41.37838669
29FGFR21.32781962
30MARK21.28089275
31KSR11.27569349
32UHMK11.26089780
33PHKG21.23173196
34PHKG11.23173196
35PKN21.23142753
36CCNB11.23084722
37CDK51.20751120
38RET1.20588958
39CAMK11.20553104
40MTOR1.20105538
41CAMKK21.19251689
42DAPK11.18796946
43NEK21.16329275
44FES1.15896681
45MAPK131.14343607
46CDK191.13942829
47PDGFRA1.11464765
48MAP2K41.07430742
49TYRO30.99888144
50SIK10.89034673
51PDK10.89009991
52SRPK10.88823327
53CDK40.86224156
54LATS20.84883324
55PINK10.84404672
56MAP3K70.83636111
57PRKCG0.82281030
58MAPK120.79399003
59FGFR30.79314814
60RIPK10.75387672
61WNK10.75147596
62DYRK1A0.74496495
63TAOK10.74425380
64MAPK110.73342189
65HIPK20.72865897
66CDK180.72703663
67STK110.72364976
68SCYL20.71787726
69CDC70.71550328
70BMX0.70939169
71TNK20.70869151
72CDK150.70650469
73SGK30.70389582
74MAP3K100.68021395
75MUSK0.67663577
76NEK60.65656953
77CAMK1D0.64810137
78CDK11A0.64022835
79EEF2K0.63362707
80CDK20.61736551
81PDGFRB0.61035483
82ALK0.60956670
83PDPK10.60515091
84SGK20.60453867
85MAP3K120.59870463
86RPS6KA20.59640910
87CDK30.58245491
88SGK10.58219942
89MAPK100.57599128
90CDK60.56278398
91CDK10.56252612
92CDK120.55756102
93BRSK10.54652123
94ERBB30.53961747
95SIK30.53503363
96CAMK40.52918847
97PRKCZ0.52811702
98IRAK20.51483491
99* ATR0.50336226
100CASK0.49779033
101MAP3K60.49686935
102TTN0.49468632
103LMTK20.48000204
104SGK2230.47369158
105SGK4940.47369158
106PRKAA10.47308249
107BRD40.46219774
108CDK140.45811307
109RPS6KA30.45445853
110MAPK150.45356039
111MAP3K130.44309656
112ERN10.44266528
113MAP4K10.43876606
114MAP2K20.42870239
115NTRK10.42824666
116SYK0.42751786
117BUB10.41990431
118MAPK140.41840387
119MAPK80.41474569
120PASK0.40153388
121GSK3B0.40036979
122PRKD20.39927739
123CDC42BPA0.39233317
124BTK0.39171738
125TTK0.38965505
126CHEK10.38053830
127RPS6KB10.37772004
128PRKCH0.37363367
129KSR20.37019750
130PRPF4B0.33860245
131FYN0.32831768
132MAPK90.32774991
133PRKCB0.32658190
134PRKDC0.31524429
135CAMK2A0.31057691

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.11087232
2Synaptic vesicle cycle_Homo sapiens_hsa047212.57125065
3Olfactory transduction_Homo sapiens_hsa047402.53734451
4Circadian entrainment_Homo sapiens_hsa047132.46132180
5Long-term potentiation_Homo sapiens_hsa047202.33334201
6Glutamatergic synapse_Homo sapiens_hsa047242.21264681
7Amphetamine addiction_Homo sapiens_hsa050312.15945013
8Morphine addiction_Homo sapiens_hsa050322.06993332
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02146688
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88585902
11GABAergic synapse_Homo sapiens_hsa047271.87318734
12Chronic myeloid leukemia_Homo sapiens_hsa052201.85103208
13Dopaminergic synapse_Homo sapiens_hsa047281.82640255
14Lysine degradation_Homo sapiens_hsa003101.77736026
15Salivary secretion_Homo sapiens_hsa049701.76022473
16Renin secretion_Homo sapiens_hsa049241.67623178
17Dorso-ventral axis formation_Homo sapiens_hsa043201.67344501
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64811792
19Phototransduction_Homo sapiens_hsa047441.62679692
20Insulin secretion_Homo sapiens_hsa049111.62386223
21Acute myeloid leukemia_Homo sapiens_hsa052211.60026540
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58594819
23Oxytocin signaling pathway_Homo sapiens_hsa049211.57687021
24Calcium signaling pathway_Homo sapiens_hsa040201.57256289
25Cholinergic synapse_Homo sapiens_hsa047251.55461408
26Gastric acid secretion_Homo sapiens_hsa049711.54517797
27Taste transduction_Homo sapiens_hsa047421.50557051
28Oocyte meiosis_Homo sapiens_hsa041141.44179243
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42594388
30Type II diabetes mellitus_Homo sapiens_hsa049301.28335622
31Pancreatic cancer_Homo sapiens_hsa052121.25614850
32Cocaine addiction_Homo sapiens_hsa050301.23982141
33cAMP signaling pathway_Homo sapiens_hsa040241.23669256
34Renal cell carcinoma_Homo sapiens_hsa052111.17224336
35Long-term depression_Homo sapiens_hsa047301.16228680
36Glucagon signaling pathway_Homo sapiens_hsa049221.15962403
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14379307
38Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10998402
39Other glycan degradation_Homo sapiens_hsa005111.10544579
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10416716
41Estrogen signaling pathway_Homo sapiens_hsa049151.10128004
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09774448
43Gap junction_Homo sapiens_hsa045401.09161371
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06261560
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05867908
46mRNA surveillance pathway_Homo sapiens_hsa030151.04820766
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04490174
48GnRH signaling pathway_Homo sapiens_hsa049121.03968877
49Axon guidance_Homo sapiens_hsa043601.03927121
50MicroRNAs in cancer_Homo sapiens_hsa052061.03365656
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02526491
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01521051
53Serotonergic synapse_Homo sapiens_hsa047260.98090386
54Prostate cancer_Homo sapiens_hsa052150.97739768
55Cell cycle_Homo sapiens_hsa041100.96630682
56Alcoholism_Homo sapiens_hsa050340.96467793
57Prion diseases_Homo sapiens_hsa050200.95561240
58VEGF signaling pathway_Homo sapiens_hsa043700.93522952
59Glioma_Homo sapiens_hsa052140.91944676
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.91913512
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90452273
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86681062
63ErbB signaling pathway_Homo sapiens_hsa040120.86517258
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.82684094
65B cell receptor signaling pathway_Homo sapiens_hsa046620.82472026
66MAPK signaling pathway_Homo sapiens_hsa040100.81808972
67Cardiac muscle contraction_Homo sapiens_hsa042600.80814794
68AMPK signaling pathway_Homo sapiens_hsa041520.80701532
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78437561
70Melanogenesis_Homo sapiens_hsa049160.77277937
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.76957826
72T cell receptor signaling pathway_Homo sapiens_hsa046600.76308817
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75765720
74Hepatitis B_Homo sapiens_hsa051610.75496870
75Fanconi anemia pathway_Homo sapiens_hsa034600.74586888
76Inositol phosphate metabolism_Homo sapiens_hsa005620.74543549
77Notch signaling pathway_Homo sapiens_hsa043300.72222963
78FoxO signaling pathway_Homo sapiens_hsa040680.71280893
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71043635
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70929001
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70089761
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.68342258
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66831044
84Wnt signaling pathway_Homo sapiens_hsa043100.66659528
85Small cell lung cancer_Homo sapiens_hsa052220.66402287
86Endocytosis_Homo sapiens_hsa041440.66063456
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65770412
88Choline metabolism in cancer_Homo sapiens_hsa052310.65566080
89Dilated cardiomyopathy_Homo sapiens_hsa054140.65530482
90Colorectal cancer_Homo sapiens_hsa052100.63323805
91Bladder cancer_Homo sapiens_hsa052190.62596833
92Circadian rhythm_Homo sapiens_hsa047100.61903168
93HIF-1 signaling pathway_Homo sapiens_hsa040660.61595583
94mTOR signaling pathway_Homo sapiens_hsa041500.59480368
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59222676
96Thyroid cancer_Homo sapiens_hsa052160.58940554
97Insulin signaling pathway_Homo sapiens_hsa049100.57750942
98Adherens junction_Homo sapiens_hsa045200.57209567
99HTLV-I infection_Homo sapiens_hsa051660.56139446
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56118180
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55641190
102Non-small cell lung cancer_Homo sapiens_hsa052230.54084529
103Endometrial cancer_Homo sapiens_hsa052130.53932738
104Focal adhesion_Homo sapiens_hsa045100.53451823
105Pancreatic secretion_Homo sapiens_hsa049720.52985084
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52798851
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.51107973
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50680048
109Pathways in cancer_Homo sapiens_hsa052000.50451260
110Fatty acid biosynthesis_Homo sapiens_hsa000610.49734196
111Rap1 signaling pathway_Homo sapiens_hsa040150.49316831
112Melanoma_Homo sapiens_hsa052180.47979803
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46998874
114Proteoglycans in cancer_Homo sapiens_hsa052050.46546621
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.46368614
116Prolactin signaling pathway_Homo sapiens_hsa049170.45636358
117Basal cell carcinoma_Homo sapiens_hsa052170.45370552
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.45246834
119Chemokine signaling pathway_Homo sapiens_hsa040620.43490753
120Hedgehog signaling pathway_Homo sapiens_hsa043400.43202164
121Platelet activation_Homo sapiens_hsa046110.42916684
122Primary immunodeficiency_Homo sapiens_hsa053400.42177928
123Ras signaling pathway_Homo sapiens_hsa040140.41964005
124Thyroid hormone synthesis_Homo sapiens_hsa049180.41367246
125N-Glycan biosynthesis_Homo sapiens_hsa005100.40953415
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39643970
127Collecting duct acid secretion_Homo sapiens_hsa049660.39186717

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