SUGT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.96234253
2ribosome assembly (GO:0042255)5.61636813
3nucleobase biosynthetic process (GO:0046112)5.26731959
4mitotic metaphase plate congression (GO:0007080)5.26460604
5proteasome assembly (GO:0043248)5.17123758
6transcription elongation from RNA polymerase III promoter (GO:0006385)4.80920021
7termination of RNA polymerase III transcription (GO:0006386)4.80920021
8DNA double-strand break processing (GO:0000729)4.79830614
9anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.62980780
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.61149241
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.58043897
12regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.55712417
13ribosome biogenesis (GO:0042254)4.54574838
147-methylguanosine mRNA capping (GO:0006370)4.52545417
15rRNA modification (GO:0000154)4.51583935
16formation of translation preinitiation complex (GO:0001731)4.44631795
17transcription elongation from RNA polymerase I promoter (GO:0006362)4.43416553
18RNA capping (GO:0036260)4.41679173
197-methylguanosine RNA capping (GO:0009452)4.41679173
20DNA replication checkpoint (GO:0000076)4.40314923
21termination of RNA polymerase I transcription (GO:0006363)4.36601740
22maturation of SSU-rRNA (GO:0030490)4.28601108
23transcription from RNA polymerase I promoter (GO:0006360)4.19638275
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.19349984
25positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.18115826
26presynaptic membrane assembly (GO:0097105)4.11791573
27negative regulation of ligase activity (GO:0051352)4.11449679
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.11449679
29regulation of spindle organization (GO:0090224)4.09828171
30metaphase plate congression (GO:0051310)4.06054974
31ribonucleoprotein complex biogenesis (GO:0022613)4.01758597
32replication fork processing (GO:0031297)4.01339649
33ribosomal large subunit biogenesis (GO:0042273)3.98841233
34positive regulation of ligase activity (GO:0051351)3.93796723
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.93419352
36regulation of cellular amino acid metabolic process (GO:0006521)3.88718109
37transcription initiation from RNA polymerase I promoter (GO:0006361)3.85458538
38spliceosomal snRNP assembly (GO:0000387)3.81135523
39response to pheromone (GO:0019236)3.80720310
40negative regulation of DNA-dependent DNA replication (GO:2000104)3.79835997
41rRNA processing (GO:0006364)3.75836763
42CENP-A containing nucleosome assembly (GO:0034080)3.75531950
43folic acid metabolic process (GO:0046655)3.74573503
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.72544584
45regulation of meiosis I (GO:0060631)3.68891751
46blastocyst development (GO:0001824)3.68043771
47regulation of ubiquitin-protein transferase activity (GO:0051438)3.67258817
48rRNA metabolic process (GO:0016072)3.63699773
49maturation of 5.8S rRNA (GO:0000460)3.62199277
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.61973684
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59508407
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59508407
53signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59508407
54presynaptic membrane organization (GO:0097090)3.58059356
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.57792187
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.57792187
57positive regulation of chromosome segregation (GO:0051984)3.54994297
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54982887
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54982887
60chromatin remodeling at centromere (GO:0031055)3.54321457
61spindle checkpoint (GO:0031577)3.52658243
62signal transduction involved in cell cycle checkpoint (GO:0072395)3.51994430
63guanosine-containing compound biosynthetic process (GO:1901070)3.50195055
64transcription elongation from RNA polymerase II promoter (GO:0006368)3.49991957
65DNA deamination (GO:0045006)3.49695448
66regulation of ligase activity (GO:0051340)3.49009438
67DNA-templated transcription, elongation (GO:0006354)3.47278547
68folic acid transport (GO:0015884)3.45625032
69amino acid salvage (GO:0043102)3.44110218
70L-methionine salvage (GO:0071267)3.44110218
71L-methionine biosynthetic process (GO:0071265)3.44110218
72mitotic spindle checkpoint (GO:0071174)3.41512816
73cell cycle G1/S phase transition (GO:0044843)3.39551678
74G1/S transition of mitotic cell cycle (GO:0000082)3.39551678
75DNA replication initiation (GO:0006270)3.38100156
76transcription-coupled nucleotide-excision repair (GO:0006283)3.37276510
77cullin deneddylation (GO:0010388)3.37147552
78rRNA methylation (GO:0031167)3.35895725
79establishment of chromosome localization (GO:0051303)3.33731458
80regulation of mitotic spindle organization (GO:0060236)3.33624506
81limb bud formation (GO:0060174)3.32302400
82histone exchange (GO:0043486)3.32041785
83positive regulation of viral transcription (GO:0050434)3.30732593
84regulation of translation in response to stress (GO:0043555)3.29800494
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.29082654
86negative regulation of sister chromatid segregation (GO:0033046)3.29082654
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.29082654
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.29082654
89negative regulation of chromosome segregation (GO:0051985)3.27685467
90cellular component biogenesis (GO:0044085)3.27124353
91positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.26370701
92DNA replication-independent nucleosome organization (GO:0034724)3.25824878
93DNA replication-independent nucleosome assembly (GO:0006336)3.25824878
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.25343506
95intraciliary transport (GO:0042073)3.24508495
96mitotic spindle assembly checkpoint (GO:0007094)3.24208539
97attachment of spindle microtubules to kinetochore (GO:0008608)3.22557557
98negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22506565
99protein deneddylation (GO:0000338)3.22183943
100kinetochore assembly (GO:0051382)3.19965085
101regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19263451
102regulation of mitotic spindle checkpoint (GO:1903504)3.19263451
103neural tube formation (GO:0001841)3.18957869
104regulation of chromosome segregation (GO:0051983)3.18148197
105pseudouridine synthesis (GO:0001522)3.17166993
106lung-associated mesenchyme development (GO:0060484)3.17090282
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15925543
108spindle assembly checkpoint (GO:0071173)3.15544160
109regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14111508
110protein localization to kinetochore (GO:0034501)3.13922573
111negative regulation of translation, ncRNA-mediated (GO:0040033)3.13630830
112regulation of translation, ncRNA-mediated (GO:0045974)3.13630830
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.13630830
114regulation of DNA endoreduplication (GO:0032875)3.10024102
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09370238
116antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08971081
117protein K6-linked ubiquitination (GO:0085020)3.08766189
118water-soluble vitamin biosynthetic process (GO:0042364)3.05689517
119pyrimidine nucleobase catabolic process (GO:0006208)3.05245064
120DNA damage response, detection of DNA damage (GO:0042769)3.00349693
121DNA replication-dependent nucleosome assembly (GO:0006335)2.93890672
122DNA replication-dependent nucleosome organization (GO:0034723)2.93890672
123resolution of meiotic recombination intermediates (GO:0000712)2.91900151
124somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91672379
125somatic hypermutation of immunoglobulin genes (GO:0016446)2.91672379
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.89735661
127respiratory chain complex IV assembly (GO:0008535)2.85687213
128synapsis (GO:0007129)2.84191809
129RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80899944
130protein prenylation (GO:0018342)2.79930673
131prenylation (GO:0097354)2.79930673
132platelet dense granule organization (GO:0060155)2.78122033
133detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74960638
134nonmotile primary cilium assembly (GO:0035058)2.74096969
135L-fucose catabolic process (GO:0042355)2.67746868
136fucose catabolic process (GO:0019317)2.67746868
137L-fucose metabolic process (GO:0042354)2.67746868
138negative regulation of DNA recombination (GO:0045910)2.66712102
139cilium morphogenesis (GO:0060271)2.65722848
140histone H2A acetylation (GO:0043968)2.65213314
141protein localization to cilium (GO:0061512)2.65172225
142exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64812760
143nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64789561
144regulation of hexokinase activity (GO:1903299)2.64722576
145regulation of glucokinase activity (GO:0033131)2.64722576
146recombinational repair (GO:0000725)2.64665777
147kidney morphogenesis (GO:0060993)2.63604863
148double-strand break repair via homologous recombination (GO:0000724)2.62770800
149retinal cone cell development (GO:0046549)2.62616863
150postreplication repair (GO:0006301)2.58195544
151mitotic sister chromatid cohesion (GO:0007064)2.57318305
152nucleobase catabolic process (GO:0046113)2.54064302
153DNA integration (GO:0015074)2.52038500
154protein neddylation (GO:0045116)2.51598940
155keratinocyte development (GO:0003334)2.51255210
156cilium organization (GO:0044782)2.50604210
157cilium assembly (GO:0042384)2.48620065
158DNA catabolic process, exonucleolytic (GO:0000738)2.48574915
159regulation of telomere maintenance (GO:0032204)2.46801143
160regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.46325191
161negative regulation of dendrite development (GO:2000171)2.46110885
162somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.45209123
163somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.45209123
164isotype switching (GO:0045190)2.45209123
165photoreceptor cell maintenance (GO:0045494)2.44673383
166protein K11-linked deubiquitination (GO:0035871)2.43476546
167cerebral cortex radially oriented cell migration (GO:0021799)2.42847039
168cytochrome complex assembly (GO:0017004)2.40136395
169lactate metabolic process (GO:0006089)2.36559456
170behavioral response to nicotine (GO:0035095)2.36358132
171histone mRNA metabolic process (GO:0008334)2.36056436
172neuron cell-cell adhesion (GO:0007158)2.35345413
173olfactory bulb development (GO:0021772)2.35052162
174axoneme assembly (GO:0035082)2.32519440
175peptidyl-histidine modification (GO:0018202)2.32452837
176retinal ganglion cell axon guidance (GO:0031290)2.31556291
177regulation of helicase activity (GO:0051095)2.31359525
178microtubule anchoring (GO:0034453)2.30866303
179somite development (GO:0061053)2.29658256
180regulation of timing of cell differentiation (GO:0048505)2.29600488
181epithelial cilium movement (GO:0003351)2.29218552
182centriole replication (GO:0007099)2.27510920
183sympathetic nervous system development (GO:0048485)2.26312968
184negative regulation of transcription regulatory region DNA binding (GO:2000678)2.26142874
185atrial cardiac muscle cell action potential (GO:0086014)2.25202536
186neurotransmitter-gated ion channel clustering (GO:0072578)2.24952124
187protein complex biogenesis (GO:0070271)2.24877886
188C4-dicarboxylate transport (GO:0015740)2.24589636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.34502491
2E2F7_22180533_ChIP-Seq_HELA_Human5.01789613
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.40078380
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.18034247
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.95031229
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.93573802
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.80538620
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.80192980
9* EST1_17652178_ChIP-ChIP_JURKAT_Human3.71407503
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13943880
11ZNF274_21170338_ChIP-Seq_K562_Hela3.07061188
12GBX2_23144817_ChIP-Seq_PC3_Human3.02106175
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98870649
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98601153
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.97692859
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95448503
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95272397
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90357073
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.85752650
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.82391191
21VDR_22108803_ChIP-Seq_LS180_Human2.76149242
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72424131
23* VDR_23849224_ChIP-Seq_CD4+_Human2.69214407
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65859676
25* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64593009
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61088387
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58510425
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52167162
29IGF1R_20145208_ChIP-Seq_DFB_Human2.48855898
30EWS_26573619_Chip-Seq_HEK293_Human2.47916686
31FUS_26573619_Chip-Seq_HEK293_Human2.46655952
32TAF15_26573619_Chip-Seq_HEK293_Human2.39913580
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36384083
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34815577
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30681672
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26179807
37XRN2_22483619_ChIP-Seq_HELA_Human2.25270129
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23832138
39* P300_19829295_ChIP-Seq_ESCs_Human2.21801402
40AR_21909140_ChIP-Seq_LNCAP_Human2.20046663
41DCP1A_22483619_ChIP-Seq_HELA_Human2.19902404
42E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16671044
43GABP_19822575_ChIP-Seq_HepG2_Human2.15513684
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12709885
45NANOG_18555785_ChIP-Seq_MESCs_Mouse2.08402331
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07071940
47FLI1_27457419_Chip-Seq_LIVER_Mouse2.05047123
48CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04818730
49FOXP3_21729870_ChIP-Seq_TREG_Human2.02406304
50YY1_21170310_ChIP-Seq_MESCs_Mouse2.02045166
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93821584
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90115753
53ELK1_19687146_ChIP-ChIP_HELA_Human1.89386314
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89105168
55TTF2_22483619_ChIP-Seq_HELA_Human1.85812946
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85574446
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84133817
58* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81879804
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77463815
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74399543
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.73996388
62* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67842951
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66958244
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66324157
65SMAD4_21799915_ChIP-Seq_A2780_Human1.60955914
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60460123
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60240485
68* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59551939
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57135413
70ER_23166858_ChIP-Seq_MCF-7_Human1.56211378
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55125475
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54371999
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53463111
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.53365316
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.53151813
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51374068
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50486587
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.46232869
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45863195
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44834106
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44747316
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.44110975
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43119648
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42823285
85BCAT_22108803_ChIP-Seq_LS180_Human1.41628107
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.41326118
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40859526
88CBP_20019798_ChIP-Seq_JUKART_Human1.40859526
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39695669
90* KDM5A_27292631_Chip-Seq_BREAST_Human1.39423016
91AR_25329375_ChIP-Seq_VCAP_Human1.39146213
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38612749
93STAT3_23295773_ChIP-Seq_U87_Human1.37588034
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36597874
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.34598492
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34234970
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32373782
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32078338
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31034717
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30004770
101* E2F1_21310950_ChIP-Seq_MCF-7_Human1.28955694
102EZH2_22144423_ChIP-Seq_EOC_Human1.28290950
103TCF4_23295773_ChIP-Seq_U87_Human1.26548622
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26038242
105* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25535780
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25437389
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25437389
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24407230
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24226405
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23958324
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23336918
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.23260022
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22632563
114TCF4_22108803_ChIP-Seq_LS180_Human1.22480028
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22477805
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22242232
117KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21577528
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20905474
119ZNF263_19887448_ChIP-Seq_K562_Human1.20784118
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20306214
121ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20300745
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19163905
123P53_22387025_ChIP-Seq_ESCs_Mouse1.17779984
124IRF1_19129219_ChIP-ChIP_H3396_Human1.17155463
125CBX2_27304074_Chip-Seq_ESCs_Mouse1.16538904
126SOX2_19829295_ChIP-Seq_ESCs_Human1.16292091
127NANOG_19829295_ChIP-Seq_ESCs_Human1.16292091
128RUNX2_22187159_ChIP-Seq_PCA_Human1.15671904
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14364929
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13033203
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12191556
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.11363600
133KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11185455
134RNF2_27304074_Chip-Seq_NSC_Mouse1.10193621
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10028464
136CRX_20693478_ChIP-Seq_RETINA_Mouse1.09425853
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.06762531
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06389348
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06389348
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06389348
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06158918
142TP53_22573176_ChIP-Seq_HFKS_Human1.06103988
143SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05764847
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05437932
145* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05233668
146CMYC_18555785_Chip-Seq_ESCs_Mouse1.04144738
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04093439
148P300_18555785_Chip-Seq_ESCs_Mouse1.03854031
149SMAD4_21741376_ChIP-Seq_EPCs_Human1.03072456
150TP63_19390658_ChIP-ChIP_HaCaT_Human1.01576509
151SOX9_26525672_Chip-Seq_HEART_Mouse1.01299110
152SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00996495
153CIITA_25753668_ChIP-Seq_RAJI_Human1.00793654
154NANOG_21062744_ChIP-ChIP_HESCs_Human1.00749365
155TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00321321
156CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00225576
157JUN_21703547_ChIP-Seq_K562_Human1.00185779
158STAT3_18555785_Chip-Seq_ESCs_Mouse0.99404290
159BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99226008
160RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97567778
161SOX17_20123909_ChIP-Seq_XEN_Mouse0.97522788
162KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96999742
163* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94292528
164POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92316418
165OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91940909
166TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91333373
167* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89667710
168SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89271582
169E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88973129
170NOTCH1_21737748_ChIP-Seq_TLL_Human0.88713672
171MYC_18940864_ChIP-ChIP_HL60_Human0.88289537
172TFEB_21752829_ChIP-Seq_HELA_Human0.88183122
173TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85921913
174* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85155486
175CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84690754
176* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84376176
177* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84191592
178* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84082885
179ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82496676
180DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82300044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.73696965
2MP0004957_abnormal_blastocyst_morpholog4.79869757
3MP0003111_abnormal_nucleus_morphology4.73062187
4MP0003718_maternal_effect4.47958373
5MP0010094_abnormal_chromosome_stability3.89215671
6MP0003077_abnormal_cell_cycle3.77672080
7MP0008260_abnormal_autophagy3.66328794
8MP0008058_abnormal_DNA_repair3.28198850
9MP0008057_abnormal_DNA_replication3.23977907
10MP0003123_paternal_imprinting3.11011478
11MP0008932_abnormal_embryonic_tissue3.06862678
12MP0003880_abnormal_central_pattern2.89031330
13MP0003786_premature_aging2.74555878
14MP0008007_abnormal_cellular_replicative2.41992416
15MP0002736_abnormal_nociception_after2.36658372
16MP0001730_embryonic_growth_arrest2.33180551
17MP0003787_abnormal_imprinting2.26486812
18MP0008877_abnormal_DNA_methylation2.07757721
19MP0006072_abnormal_retinal_apoptosis2.01226641
20MP0001984_abnormal_olfaction1.99299640
21MP0001968_abnormal_touch/_nociception1.96723560
22MP0001542_abnormal_bone_strength1.90106118
23MP0003315_abnormal_perineum_morphology1.89314049
24MP0000350_abnormal_cell_proliferation1.88269572
25MP0003195_calcinosis1.84745583
26MP0003941_abnormal_skin_development1.83219696
27MP0009046_muscle_twitch1.80218972
28MP0005551_abnormal_eye_electrophysiolog1.76386779
29MP0000569_abnormal_digit_pigmentation1.74696113
30MP0002837_dystrophic_cardiac_calcinosis1.74378703
31MP0003136_yellow_coat_color1.72685767
32MP0009333_abnormal_splenocyte_physiolog1.71645837
33MP0003122_maternal_imprinting1.68678700
34MP0001672_abnormal_embryogenesis/_devel1.68655067
35MP0005380_embryogenesis_phenotype1.68655067
36MP0002751_abnormal_autonomic_nervous1.61978247
37MP0005253_abnormal_eye_physiology1.61517126
38MP0003890_abnormal_embryonic-extraembry1.59743010
39MP0005395_other_phenotype1.59476421
40MP0005451_abnormal_body_composition1.55637362
41MP0001661_extended_life_span1.53360756
42MP0002163_abnormal_gland_morphology1.52003297
43MP0001486_abnormal_startle_reflex1.50285190
44MP0005377_hearing/vestibular/ear_phenot1.49213696
45MP0003878_abnormal_ear_physiology1.49213696
46MP0002210_abnormal_sex_determination1.48761567
47MP0001697_abnormal_embryo_size1.47694242
48MP0000778_abnormal_nervous_system1.46731348
49MP0000631_abnormal_neuroendocrine_gland1.46585524
50MP0004133_heterotaxia1.46295419
51MP0002938_white_spotting1.44535043
52MP0002080_prenatal_lethality1.41525719
53MP0004215_abnormal_myocardial_fiber1.41474736
54MP0004270_analgesia1.40279204
55MP0008789_abnormal_olfactory_epithelium1.40159349
56MP0004147_increased_porphyrin_level1.39294527
57MP0003938_abnormal_ear_development1.39001794
58MP0003984_embryonic_growth_retardation1.38968772
59MP0009745_abnormal_behavioral_response1.38953996
60MP0002088_abnormal_embryonic_growth/wei1.36062167
61MP0003567_abnormal_fetal_cardiomyocyte1.35937864
62MP0003221_abnormal_cardiomyocyte_apopto1.32995999
63MP0002272_abnormal_nervous_system1.31412810
64MP0010307_abnormal_tumor_latency1.28706247
65MP0006035_abnormal_mitochondrial_morpho1.28088754
66MP0001145_abnormal_male_reproductive1.28007293
67MP0001929_abnormal_gametogenesis1.27993364
68MP0005187_abnormal_penis_morphology1.24175261
69MP0002160_abnormal_reproductive_system1.23870209
70MP0002085_abnormal_embryonic_tissue1.23180512
71MP0002734_abnormal_mechanical_nocicepti1.21259751
72MP0009840_abnormal_foam_cell1.19966281
73MP0006276_abnormal_autonomic_nervous1.19789530
74MP0001188_hyperpigmentation1.19785126
75MP0000750_abnormal_muscle_regeneration1.19231607
76MP0002638_abnormal_pupillary_reflex1.18353734
77MP0005389_reproductive_system_phenotype1.16656962
78MP0000653_abnormal_sex_gland1.15887849
79MP0002735_abnormal_chemical_nociception1.15591843
80MP0002132_abnormal_respiratory_system1.15183368
81MP0005646_abnormal_pituitary_gland1.13899175
82MP0005645_abnormal_hypothalamus_physiol1.13225717
83MP0000427_abnormal_hair_cycle1.13214710
84MP0005499_abnormal_olfactory_system1.11777061
85MP0005394_taste/olfaction_phenotype1.11777061
86MP0002234_abnormal_pharynx_morphology1.10835671
87MP0006292_abnormal_olfactory_placode1.10824583
88MP0002102_abnormal_ear_morphology1.09739629
89MP0000313_abnormal_cell_death1.08939818
90MP0001177_atelectasis1.07127273
91MP0001529_abnormal_vocalization1.06874371
92MP0003186_abnormal_redox_activity1.06726962
93MP0000358_abnormal_cell_content/1.06636556
94MP0002233_abnormal_nose_morphology1.06465783
95MP0002653_abnormal_ependyma_morphology1.06142139
96MP0004084_abnormal_cardiac_muscle1.05847224
97MP0003635_abnormal_synaptic_transmissio1.04462037
98MP0004924_abnormal_behavior1.02559097
99MP0005386_behavior/neurological_phenoty1.02559097
100MP0008872_abnormal_physiological_respon1.02269485
101MP0001905_abnormal_dopamine_level1.02045561
102MP0002557_abnormal_social/conspecific_i1.01875853
103MP0002184_abnormal_innervation1.01591266
104MP0004043_abnormal_pH_regulation1.01501333
105MP0002084_abnormal_developmental_patter1.00447828
106MP0002064_seizures0.98368285
107MP0001727_abnormal_embryo_implantation0.96327098
108MP0006036_abnormal_mitochondrial_physio0.96100769
109MP0002086_abnormal_extraembryonic_tissu0.95793776
110MP0002067_abnormal_sensory_capabilities0.95748413
111MP0002572_abnormal_emotion/affect_behav0.95621012
112MP0000372_irregular_coat_pigmentation0.94750423
113MP0003137_abnormal_impulse_conducting0.93410029
114MP0003937_abnormal_limbs/digits/tail_de0.91673190
115MP0002396_abnormal_hematopoietic_system0.91132246
116MP0002063_abnormal_learning/memory/cond0.89374405
117MP0003806_abnormal_nucleotide_metabolis0.87734983
118MP0003121_genomic_imprinting0.87605898
119MP0008995_early_reproductive_senescence0.87267239
120MP0002752_abnormal_somatic_nervous0.86859723
121MP0002277_abnormal_respiratory_mucosa0.84056674
122MP0005174_abnormal_tail_pigmentation0.83770571
123MP0005195_abnormal_posterior_eye0.83532693
124MP0004142_abnormal_muscle_tone0.83454182
125MP0000627_abnormal_mammary_gland0.82721147
126MP0002254_reproductive_system_inflammat0.82071092
127MP0005391_vision/eye_phenotype0.81851314
128MP0002090_abnormal_vision0.81635465
129MP0010386_abnormal_urinary_bladder0.80600126
130MP0003698_abnormal_male_reproductive0.80307289
131MP0005384_cellular_phenotype0.80145225
132MP0005379_endocrine/exocrine_gland_phen0.79474195
133MP0001970_abnormal_pain_threshold0.79302794
134MP0001119_abnormal_female_reproductive0.78446576
135MP0003646_muscle_fatigue0.76861057
136MP0003119_abnormal_digestive_system0.76390976
137MP0002019_abnormal_tumor_incidence0.75526611
138MP0005621_abnormal_cell_physiology0.74800732
139MP0002127_abnormal_cardiovascular_syste0.74680912
140MP0002161_abnormal_fertility/fecundity0.72960964
141MP0003936_abnormal_reproductive_system0.72857133
142MP0001919_abnormal_reproductive_system0.71748011
143MP0001545_abnormal_hematopoietic_system0.68775223
144MP0005397_hematopoietic_system_phenotyp0.68775223
145MP0001293_anophthalmia0.65896404
146MP0001485_abnormal_pinna_reflex0.64030471
147MP0003699_abnormal_female_reproductive0.63092475
148MP0009672_abnormal_birth_weight0.60366888
149MP0001440_abnormal_grooming_behavior0.60060637
150MP0001756_abnormal_urination0.59948522
151MP0000490_abnormal_crypts_of0.58883920
152MP0000428_abnormal_craniofacial_morphol0.58347275
153MP0005367_renal/urinary_system_phenotyp0.57978897
154MP0000516_abnormal_urinary_system0.57978897
155MP0001764_abnormal_homeostasis0.57933524
156MP0004197_abnormal_fetal_growth/weight/0.57531969
157MP0000647_abnormal_sebaceous_gland0.55694406
158MP0009697_abnormal_copulation0.53120239
159MP0003879_abnormal_hair_cell0.50620550
160MP0000747_muscle_weakness0.49485728
161MP0009703_decreased_birth_body0.47559067
162MP0001286_abnormal_eye_development0.47035945
163MP0002111_abnormal_tail_morphology0.46613127
164MP0003755_abnormal_palate_morphology0.43487455

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.99292933
2Breast hypoplasia (HP:0003187)5.75466578
3Cerebral hypomyelination (HP:0006808)4.93769108
4Carpal bone hypoplasia (HP:0001498)4.34310042
5Impulsivity (HP:0100710)4.12161573
6Rough bone trabeculation (HP:0100670)4.10089651
7Hyperglycinemia (HP:0002154)3.87492188
8Patellar aplasia (HP:0006443)3.72106387
9Aplasia/Hypoplasia of the patella (HP:0006498)3.66619404
10Abnormality of the umbilical cord (HP:0010881)3.60840799
11Ureteral duplication (HP:0000073)3.39010924
12Abnormality of the labia minora (HP:0012880)3.38770751
13Secondary amenorrhea (HP:0000869)3.16766538
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.15599692
15Abnormal trabecular bone morphology (HP:0100671)3.10866595
16True hermaphroditism (HP:0010459)3.10830790
17Absent radius (HP:0003974)3.09294108
18CNS hypomyelination (HP:0003429)3.07028762
19Volvulus (HP:0002580)3.04611026
20Abnormality of the anterior horn cell (HP:0006802)3.02368811
21Degeneration of anterior horn cells (HP:0002398)3.02368811
22Medial flaring of the eyebrow (HP:0010747)2.97397970
23Abnormality of midbrain morphology (HP:0002418)2.96177588
24Molar tooth sign on MRI (HP:0002419)2.96177588
25Premature ovarian failure (HP:0008209)2.93366368
26Aplasia involving forearm bones (HP:0009822)2.92304719
27Absent forearm bone (HP:0003953)2.92304719
28Multiple enchondromatosis (HP:0005701)2.89750703
29Hyperglycinuria (HP:0003108)2.86695219
30Hyperventilation (HP:0002883)2.82190973
31Intestinal atresia (HP:0011100)2.72778680
32Methylmalonic acidemia (HP:0002912)2.65967796
33Oral leukoplakia (HP:0002745)2.63668197
34Gait imbalance (HP:0002141)2.60693316
35Delusions (HP:0000746)2.59606399
36Aplasia/Hypoplasia involving the musculature (HP:0001460)2.58313640
37Colon cancer (HP:0003003)2.56978166
38Congenital primary aphakia (HP:0007707)2.56129178
39Entropion (HP:0000621)2.53557765
40Abnormality of glycolysis (HP:0004366)2.53316144
41Increased serum pyruvate (HP:0003542)2.53316144
42Nephronophthisis (HP:0000090)2.52411150
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.51298728
44Macrocytic anemia (HP:0001972)2.49238548
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48600171
46Abnormality of alanine metabolism (HP:0010916)2.48600171
47Hyperalaninemia (HP:0003348)2.48600171
48Patent foramen ovale (HP:0001655)2.47642453
49Genital tract atresia (HP:0001827)2.46838325
50Horseshoe kidney (HP:0000085)2.46699196
51Abnormality of chromosome stability (HP:0003220)2.45777253
52Broad-based gait (HP:0002136)2.44562756
53Supernumerary spleens (HP:0009799)2.43882988
54Sparse eyelashes (HP:0000653)2.43512662
55Pancreatic fibrosis (HP:0100732)2.43196974
56Areflexia of lower limbs (HP:0002522)2.43190925
57Abnormal spermatogenesis (HP:0008669)2.42890074
58Ependymoma (HP:0002888)2.41628416
59Death in infancy (HP:0001522)2.40236948
60Abnormalities of placenta or umbilical cord (HP:0001194)2.40120701
61Postnatal microcephaly (HP:0005484)2.38750580
62Cleft eyelid (HP:0000625)2.38366741
63Personality changes (HP:0000751)2.37286107
64Abnormality of the fetal cardiovascular system (HP:0010948)2.36471589
65Abnormal umbilical cord blood vessels (HP:0011403)2.36471589
66Single umbilical artery (HP:0001195)2.36471589
673-Methylglutaconic aciduria (HP:0003535)2.36188520
68Vaginal atresia (HP:0000148)2.35988345
69Congenital, generalized hypertrichosis (HP:0004540)2.35868091
70Microretrognathia (HP:0000308)2.35794164
71Abnormality of the astrocytes (HP:0100707)2.33061893
72Astrocytoma (HP:0009592)2.33061893
73Abnormality of glycine metabolism (HP:0010895)2.32470132
74Abnormality of serine family amino acid metabolism (HP:0010894)2.32470132
75Prolonged neonatal jaundice (HP:0006579)2.31366428
76Nephrogenic diabetes insipidus (HP:0009806)2.31290105
77Abnormality of serum amino acid levels (HP:0003112)2.29679654
78Glioma (HP:0009733)2.28107307
79Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.27529447
80Trismus (HP:0000211)2.25637126
81Abnormality of cells of the erythroid lineage (HP:0012130)2.24455416
82Progressive muscle weakness (HP:0003323)2.24046412
83Meckel diverticulum (HP:0002245)2.23795621
84Megaloblastic anemia (HP:0001889)2.22665033
85Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21912756
86Oligodactyly (hands) (HP:0001180)2.21702927
87Type II lissencephaly (HP:0007260)2.20740418
88Progressive inability to walk (HP:0002505)2.19409903
89Absent speech (HP:0001344)2.18118837
90Adrenal hypoplasia (HP:0000835)2.15903629
91Abnormality of the renal medulla (HP:0100957)2.15835812
92Irregular epiphyses (HP:0010582)2.15472300
93Abnormality of the preputium (HP:0100587)2.14468187
94Breast aplasia (HP:0100783)2.13531160
95Abnormality of the renal cortex (HP:0011035)2.12488337
96Dysautonomia (HP:0002459)2.12092334
97CNS demyelination (HP:0007305)2.11740717
98Postaxial hand polydactyly (HP:0001162)2.10314502
99Short nail (HP:0001799)2.09967003
100Progressive macrocephaly (HP:0004481)2.08989131
101Chronic hepatic failure (HP:0100626)2.08760918
102Small hand (HP:0200055)2.08666431
103Aplasia/Hypoplasia of the tongue (HP:0010295)2.08357075
104Abolished electroretinogram (ERG) (HP:0000550)2.08005598
105Oligodactyly (HP:0012165)2.07734826
106Inability to walk (HP:0002540)2.07151508
107Aplasia/Hypoplasia of the breasts (HP:0010311)2.05887158
108Glossoptosis (HP:0000162)2.03612766
109Abnormality of the ileum (HP:0001549)2.03486973
110Hypothermia (HP:0002045)2.02904725
111Abnormal lung lobation (HP:0002101)2.02867486
112Stenosis of the external auditory canal (HP:0000402)2.02370385
113Drooling (HP:0002307)2.02089440
114Shoulder girdle muscle weakness (HP:0003547)2.00543097
115Methylmalonic aciduria (HP:0012120)1.99694871
116Premature graying of hair (HP:0002216)1.99541109
117Sloping forehead (HP:0000340)1.99501875
118Abnormal number of erythroid precursors (HP:0012131)1.99414597
119Increased hepatocellular lipid droplets (HP:0006565)1.98957755
120Pancreatic cysts (HP:0001737)1.98022415
121Renal cortical cysts (HP:0000803)1.97412322
122Acute necrotizing encephalopathy (HP:0006965)1.96612221
123Reticulocytopenia (HP:0001896)1.96159887
124Postaxial foot polydactyly (HP:0001830)1.96049205
125Brittle hair (HP:0002299)1.95991745
126Pendular nystagmus (HP:0012043)1.93972957
127Tubulointerstitial nephritis (HP:0001970)1.93943972
128Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93736224
129Muscle fiber splitting (HP:0003555)1.93476582
130Neoplasm of the adrenal cortex (HP:0100641)1.92861225
131Double outlet right ventricle (HP:0001719)1.92790705
132Congenital malformation of the right heart (HP:0011723)1.92790705
133Increased serum lactate (HP:0002151)1.90321910
134Unsteady gait (HP:0002317)1.90316360
135Focal motor seizures (HP:0011153)1.90184609
136Stillbirth (HP:0003826)1.89817430
137Absent hand (HP:0004050)1.89480624
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.87986969
139Gout (HP:0001997)1.87758720
140Cellular immunodeficiency (HP:0005374)1.87276774
141Astigmatism (HP:0000483)1.87035830
142Male pseudohermaphroditism (HP:0000037)1.86898612
143Cystic liver disease (HP:0006706)1.86695390
144Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86682155
145Aplasia/hypoplasia of the uterus (HP:0008684)1.86069832
146Lissencephaly (HP:0001339)1.86064974
147Absent thumb (HP:0009777)1.85961191
148Poor coordination (HP:0002370)1.85783901
149Bone marrow hypocellularity (HP:0005528)1.85735358
150Duodenal stenosis (HP:0100867)1.85580041
151Small intestinal stenosis (HP:0012848)1.85580041
152Abnormality of the distal phalanges of the toes (HP:0010182)1.85076787
153Gaze-evoked nystagmus (HP:0000640)1.83986805
154Split foot (HP:0001839)1.83221410
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.82181909
156Congenital stationary night blindness (HP:0007642)1.82054378
157Bifid tongue (HP:0010297)1.81520401
158Dandy-Walker malformation (HP:0001305)1.81228546
159Abnormality of the duodenum (HP:0002246)1.80498728
160Acute encephalopathy (HP:0006846)1.80337015
161Sclerocornea (HP:0000647)1.79868607
162Abnormality of vitamin B metabolism (HP:0004340)1.79797000
163Febrile seizures (HP:0002373)1.79221558
164Rhabdomyosarcoma (HP:0002859)1.78620171
165Anencephaly (HP:0002323)1.78543466
166Gastrointestinal atresia (HP:0002589)1.78377700
167Aqueductal stenosis (HP:0002410)1.77366799
168Fair hair (HP:0002286)1.76547420
169Preaxial hand polydactyly (HP:0001177)1.75074232
170Excessive salivation (HP:0003781)1.74985263
171Increased CSF lactate (HP:0002490)1.74879683
172Optic nerve hypoplasia (HP:0000609)1.74272211
173Narrow forehead (HP:0000341)1.73917095
174Renal hypoplasia (HP:0000089)1.72991411
175Abnormality of the vitamin B12 metabolism (HP:0004341)1.72878732
176Median cleft lip (HP:0000161)1.72713606
177Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70627194
178Abnormal hair whorl (HP:0010721)1.70426690
179Furrowed tongue (HP:0000221)1.69657506
180Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68169030
181Protruding tongue (HP:0010808)1.67595127
182Focal seizures (HP:0007359)1.66954830
183Abnormality of the metopic suture (HP:0005556)1.66627753
184Congenital hepatic fibrosis (HP:0002612)1.66392718
185Cupped ear (HP:0000378)1.64974751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.17973980
2WEE15.18136556
3FRK4.32333048
4EIF2AK13.56030731
5TSSK63.23491924
6PLK43.06304991
7TNIK2.97691782
8TRIM282.81926021
9STK162.74655913
10SRPK12.71963327
11NME22.70992589
12PNCK2.69618568
13BRSK22.48050499
14BMPR1B2.45753619
15EPHA22.44065868
16AKT32.43436430
17CASK2.28363981
18MAP4K22.20408655
19EIF2AK32.12618732
20MAP3K42.12171264
21PLK32.08201243
22NEK22.07653218
23MAPK132.06456945
24MKNK21.94268438
25MARK11.94034590
26TTK1.90432584
27ERBB31.78994465
28MKNK11.73352262
29* PLK11.73329391
30ARAF1.72434647
31ACVR1B1.65102692
32ZAK1.62603065
33DYRK31.57654812
34NEK11.56128192
35BRSK11.51438509
36BRAF1.48035962
37CDC71.40425953
38CCNB11.38076688
39GRK11.36654013
40EPHA41.36079512
41MAP2K71.34845999
42PDK41.33718012
43PDK31.33718012
44NME11.26917852
45AURKA1.24779687
46STK391.22877952
47FGFR21.21399280
48STK38L1.20837801
49AURKB1.20293158
50TESK21.19165384
51PDK21.18359402
52VRK11.18081015
53PIM21.17610372
54ADRBK21.13211467
55CHEK21.10490993
56EIF2AK21.01066971
57LATS20.98135125
58INSRR0.97143281
59DYRK20.94911777
60PAK30.93870744
61MST40.92294200
62PBK0.90712403
63PRKCE0.85805010
64TLK10.85317575
65TGFBR10.82441835
66MINK10.82401607
67CSNK1G30.79209853
68BCR0.78772775
69PINK10.76490786
70CDK70.75412625
71PRKCI0.72493923
72MAP3K80.72137580
73STK30.70124503
74PAK10.69607346
75CHEK10.68494146
76WNK40.68206037
77STK240.66816728
78CSNK2A10.65772995
79FER0.65718143
80NUAK10.65429594
81CSNK1G10.65324404
82RPS6KA40.62875501
83LATS10.61586636
84CSNK2A20.61261932
85TIE10.59999367
86YES10.59916192
87ATR0.59491409
88IRAK30.58211698
89ALK0.56491609
90CDK40.53828793
91NTRK20.53544528
92PKN10.50012749
93CDK20.48394108
94CSNK1E0.46555871
95ABL20.45307005
96RPS6KA50.45189617
97NTRK30.44366208
98CSNK1A1L0.43900221
99RPS6KB20.43877676
100PHKG20.43587109
101PHKG10.43587109
102ADRBK10.43194282
103PIM10.43061958
104TAF10.42672212
105CSNK1G20.42414748
106SGK20.42262112
107BRD40.41332125
108CAMK2A0.40561000
109CSNK1D0.40451177
110MELK0.39960770
111STK40.39020736
112STK110.37781151
113BCKDK0.37607525
114CDK10.37209789
115PRKD30.36354155
116PLK20.36277402
117UHMK10.35230481
118NEK60.34543221
119FGFR10.32488147
120ATM0.30788043
121PRKCG0.30585866
122ROCK10.30504243
123PRKG10.30433636
124LIMK10.30405498
125MUSK0.30404900
126MAP2K40.29430896
127CSNK1A10.29343042
128CAMK2D0.28531814
129CDK30.28424533
130CDK80.26197942
131BMPR20.24809367
132CAMKK20.23627993
133PAK40.23235094
134MAP2K20.21397626
135RAF10.20695580
136MARK30.20335813
137GRK50.19263175
138OBSCN0.15396335
139WNK30.15216429
140NLK0.11244679
141AKT20.10581953
142CDK140.10053595
143STK100.09409377
144NEK90.08575530
145OXSR10.08489475
146MAP3K50.07863224
147IKBKB0.07832899

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.24130347
2RNA polymerase_Homo sapiens_hsa030205.00737802
3Vitamin B6 metabolism_Homo sapiens_hsa007504.77135234
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.40463647
5RNA transport_Homo sapiens_hsa030133.33126940
6Ribosome_Homo sapiens_hsa030103.16744600
7DNA replication_Homo sapiens_hsa030302.95174583
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.92244524
9Spliceosome_Homo sapiens_hsa030402.86033241
10Pyrimidine metabolism_Homo sapiens_hsa002402.76028288
11Mismatch repair_Homo sapiens_hsa034302.65784427
12Propanoate metabolism_Homo sapiens_hsa006402.50298948
13Basal transcription factors_Homo sapiens_hsa030222.47306741
14Cell cycle_Homo sapiens_hsa041102.34732036
15Nucleotide excision repair_Homo sapiens_hsa034202.34189782
16Homologous recombination_Homo sapiens_hsa034402.28831225
17Butanoate metabolism_Homo sapiens_hsa006502.13916778
18Regulation of autophagy_Homo sapiens_hsa041402.02808316
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94288920
20Base excision repair_Homo sapiens_hsa034101.93761901
21Phototransduction_Homo sapiens_hsa047441.88704657
22Nicotine addiction_Homo sapiens_hsa050331.80526800
23Purine metabolism_Homo sapiens_hsa002301.79167045
24Fanconi anemia pathway_Homo sapiens_hsa034601.59292575
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49773796
26p53 signaling pathway_Homo sapiens_hsa041151.46676847
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46517891
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45828468
29RNA degradation_Homo sapiens_hsa030181.43717890
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.43158651
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41220567
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40649513
33Epstein-Barr virus infection_Homo sapiens_hsa051691.40467605
34Folate biosynthesis_Homo sapiens_hsa007901.38621454
35Oxidative phosphorylation_Homo sapiens_hsa001901.36152378
36Oocyte meiosis_Homo sapiens_hsa041141.30235511
37Huntingtons disease_Homo sapiens_hsa050161.29535710
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25602685
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25553551
40Pentose phosphate pathway_Homo sapiens_hsa000301.21007229
41mRNA surveillance pathway_Homo sapiens_hsa030151.20955479
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20305407
43Tryptophan metabolism_Homo sapiens_hsa003801.16984464
44Parkinsons disease_Homo sapiens_hsa050121.15779601
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11856037
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10468910
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09280317
48Taste transduction_Homo sapiens_hsa047421.07058290
49Nitrogen metabolism_Homo sapiens_hsa009101.06282638
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.04591757
51One carbon pool by folate_Homo sapiens_hsa006701.01929180
52Fatty acid elongation_Homo sapiens_hsa000621.00406257
53Caffeine metabolism_Homo sapiens_hsa002320.98462522
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98312671
55GABAergic synapse_Homo sapiens_hsa047270.97510221
56Peroxisome_Homo sapiens_hsa041460.96972558
57Olfactory transduction_Homo sapiens_hsa047400.96024796
58Circadian entrainment_Homo sapiens_hsa047130.95129393
59Protein export_Homo sapiens_hsa030600.93279084
60Non-homologous end-joining_Homo sapiens_hsa034500.91084564
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.90703693
62beta-Alanine metabolism_Homo sapiens_hsa004100.88050464
63Dopaminergic synapse_Homo sapiens_hsa047280.85203415
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84404218
65Pyruvate metabolism_Homo sapiens_hsa006200.83928621
66Glutamatergic synapse_Homo sapiens_hsa047240.83879053
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82198997
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81208986
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80585211
70Morphine addiction_Homo sapiens_hsa050320.79757551
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78090637
72Fructose and mannose metabolism_Homo sapiens_hsa000510.76833698
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.73560049
74Amphetamine addiction_Homo sapiens_hsa050310.72435747
75Fatty acid metabolism_Homo sapiens_hsa012120.71266264
76Collecting duct acid secretion_Homo sapiens_hsa049660.67801394
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67621627
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66135239
79Insulin secretion_Homo sapiens_hsa049110.64503049
80Serotonergic synapse_Homo sapiens_hsa047260.63981763
81Retinol metabolism_Homo sapiens_hsa008300.63021910
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.62274913
83Vitamin digestion and absorption_Homo sapiens_hsa049770.61610804
84Biosynthesis of amino acids_Homo sapiens_hsa012300.61300930
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61227612
86Antigen processing and presentation_Homo sapiens_hsa046120.60945819
87Fatty acid degradation_Homo sapiens_hsa000710.60797955
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60056982
89Sulfur relay system_Homo sapiens_hsa041220.60025292
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.59136415
91Glutathione metabolism_Homo sapiens_hsa004800.58859482
92Chemical carcinogenesis_Homo sapiens_hsa052040.53980587
93Alzheimers disease_Homo sapiens_hsa050100.53780751
94Wnt signaling pathway_Homo sapiens_hsa043100.53638188
95Metabolic pathways_Homo sapiens_hsa011000.52713258
96Arachidonic acid metabolism_Homo sapiens_hsa005900.50884633
97Basal cell carcinoma_Homo sapiens_hsa052170.50802151
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50604461
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47078142
100ABC transporters_Homo sapiens_hsa020100.45196770
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43401916
102Carbon metabolism_Homo sapiens_hsa012000.40453987
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39374435
104Long-term depression_Homo sapiens_hsa047300.39043131
105Rheumatoid arthritis_Homo sapiens_hsa053230.36150774
106Viral carcinogenesis_Homo sapiens_hsa052030.35019094
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34064293
108Herpes simplex infection_Homo sapiens_hsa051680.33937747
109Circadian rhythm_Homo sapiens_hsa047100.30391862
110Sphingolipid metabolism_Homo sapiens_hsa006000.29749966
111Linoleic acid metabolism_Homo sapiens_hsa005910.28299546
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.27455447
113Systemic lupus erythematosus_Homo sapiens_hsa053220.26503773
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24595068
115Arginine and proline metabolism_Homo sapiens_hsa003300.24085883
116Graft-versus-host disease_Homo sapiens_hsa053320.23337840
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21486573
118Allograft rejection_Homo sapiens_hsa053300.20418380
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19871321
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19081169
121Autoimmune thyroid disease_Homo sapiens_hsa053200.18579329
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18024536
123Cardiac muscle contraction_Homo sapiens_hsa042600.18024338
124Ether lipid metabolism_Homo sapiens_hsa005650.17805180
125Hippo signaling pathway_Homo sapiens_hsa043900.17683411
126HTLV-I infection_Homo sapiens_hsa051660.17554756
127Legionellosis_Homo sapiens_hsa051340.16193434
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.14065684
129Renin-angiotensin system_Homo sapiens_hsa046140.13431063
130Tight junction_Homo sapiens_hsa045300.12738963
131FoxO signaling pathway_Homo sapiens_hsa040680.12147598
132Steroid biosynthesis_Homo sapiens_hsa001000.11116857
133Mineral absorption_Homo sapiens_hsa049780.09548463
134HIF-1 signaling pathway_Homo sapiens_hsa040660.07704492
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07238551
136Vibrio cholerae infection_Homo sapiens_hsa051100.05582324
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05161771
138Hedgehog signaling pathway_Homo sapiens_hsa043400.04760523
139Lysosome_Homo sapiens_hsa041420.04378278
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03439268
141Selenocompound metabolism_Homo sapiens_hsa004500.02536113
142Galactose metabolism_Homo sapiens_hsa000520.02156850
143Apoptosis_Homo sapiens_hsa042100.01898854
144Asthma_Homo sapiens_hsa053100.00550040
145mTOR signaling pathway_Homo sapiens_hsa04150-0.0142679
146TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0132211
147MicroRNAs in cancer_Homo sapiens_hsa05206-0.0099506
148Thyroid cancer_Homo sapiens_hsa05216-0.0074587

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