SUGT1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of action potential (GO:0045760)5.29756535
2behavioral response to nicotine (GO:0035095)4.79973234
3fusion of sperm to egg plasma membrane (GO:0007342)4.59963630
4gamma-aminobutyric acid transport (GO:0015812)4.22008388
5CENP-A containing nucleosome assembly (GO:0034080)4.16477038
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.07940288
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.07940288
8NADH dehydrogenase complex assembly (GO:0010257)4.07940288
9neuronal action potential propagation (GO:0019227)4.04485091
10chromatin remodeling at centromere (GO:0031055)4.04151301
11positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.01979811
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.00884886
13meiotic chromosome segregation (GO:0045132)3.99057794
14kinetochore assembly (GO:0051382)3.97831982
15centriole replication (GO:0007099)3.96690102
16regulation of acrosome reaction (GO:0060046)3.92953995
17protein-cofactor linkage (GO:0018065)3.84733174
18neuronal action potential (GO:0019228)3.84448695
19histone exchange (GO:0043486)3.75739247
20protein complex biogenesis (GO:0070271)3.74884012
21regulation of mitotic spindle checkpoint (GO:1903504)3.73093374
22regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.73093374
23regulation of cell communication by electrical coupling (GO:0010649)3.72817537
24histone H4-K12 acetylation (GO:0043983)3.72415431
25kinetochore organization (GO:0051383)3.70420335
26detection of light stimulus involved in sensory perception (GO:0050962)3.51119388
27detection of light stimulus involved in visual perception (GO:0050908)3.51119388
28synapsis (GO:0007129)3.47209959
29histone H3-K9 methylation (GO:0051567)3.43108272
30mitochondrial respiratory chain complex assembly (GO:0033108)3.40721587
31serotonin metabolic process (GO:0042428)3.39256041
32negative regulation of transcription regulatory region DNA binding (GO:2000678)3.32065785
33negative regulation of translation, ncRNA-mediated (GO:0040033)3.30680857
34regulation of translation, ncRNA-mediated (GO:0045974)3.30680857
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30680857
36plasma membrane fusion (GO:0045026)3.28555179
37primary amino compound metabolic process (GO:1901160)3.28312583
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28033622
39protein K11-linked deubiquitination (GO:0035871)3.26363629
40behavioral response to ethanol (GO:0048149)3.15447373
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12571437
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11941372
43negative regulation of heart rate (GO:0010459)3.07570461
44cellular ketone body metabolic process (GO:0046950)3.06502327
45positive regulation of sodium ion transmembrane transport (GO:1902307)3.06473583
46double-strand break repair via homologous recombination (GO:0000724)3.03623611
47vitamin transmembrane transport (GO:0035461)3.03410218
48regulation of cilium movement (GO:0003352)3.02448929
49recombinational repair (GO:0000725)3.01780481
50mitochondrial calcium ion transport (GO:0006851)3.01731558
51regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.01510920
52positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.01510920
53resolution of meiotic recombination intermediates (GO:0000712)2.99466182
54negative regulation of DNA-dependent DNA replication (GO:2000104)2.99119486
55neural tube formation (GO:0001841)2.98970803
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98035925
57replication fork processing (GO:0031297)2.97784870
58DNA replication checkpoint (GO:0000076)2.96539447
59regulation of action potential (GO:0098900)2.90195745
60positive regulation of mRNA 3-end processing (GO:0031442)2.84222337
61ketone body metabolic process (GO:1902224)2.81531392
62DNA replication-independent nucleosome assembly (GO:0006336)2.79159760
63DNA replication-independent nucleosome organization (GO:0034724)2.79159760
64positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.78848446
65regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.78848446
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78744849
67respiratory chain complex IV assembly (GO:0008535)2.78682678
68oxidative demethylation (GO:0070989)2.78136040
69monoubiquitinated protein deubiquitination (GO:0035520)2.76905010
70energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76139851
71ATP synthesis coupled proton transport (GO:0015986)2.76139851
72positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.73715972
73positive regulation of mRNA processing (GO:0050685)2.73526684
74protein prenylation (GO:0018342)2.72660203
75prenylation (GO:0097354)2.72660203
76phosphatidylinositol acyl-chain remodeling (GO:0036149)2.71959103
77histone H3-K9 modification (GO:0061647)2.71542801
78Peyers patch development (GO:0048541)2.71157479
79mucosal-associated lymphoid tissue development (GO:0048537)2.71157479
80histone-serine phosphorylation (GO:0035404)2.71064976
81phosphatidylserine acyl-chain remodeling (GO:0036150)2.70263246
82arginine catabolic process (GO:0006527)2.69591828
83positive regulation of protein targeting to membrane (GO:0090314)2.68985912
84centrosome organization (GO:0051297)2.68191239
85protein localization to kinetochore (GO:0034501)2.67609936
86mitochondrial RNA metabolic process (GO:0000959)2.66194690
87L-fucose catabolic process (GO:0042355)2.66151688
88fucose catabolic process (GO:0019317)2.66151688
89L-fucose metabolic process (GO:0042354)2.66151688
90regulation of memory T cell differentiation (GO:0043380)2.66085585
91positive regulation of T-helper 1 type immune response (GO:0002827)2.65492510
92attachment of spindle microtubules to kinetochore (GO:0008608)2.65303155
93microtubule organizing center organization (GO:0031023)2.63869285
94DNA deamination (GO:0045006)2.62382412
95male meiosis I (GO:0007141)2.61915804
96regulation of mRNA 3-end processing (GO:0031440)2.59424396
97piRNA metabolic process (GO:0034587)2.58543174
98seminiferous tubule development (GO:0072520)2.58406434
99positive regulation of mRNA catabolic process (GO:0061014)2.57511595
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55638696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.37208691
2VDR_22108803_ChIP-Seq_LS180_Human4.11067002
3ZNF274_21170338_ChIP-Seq_K562_Hela3.32880596
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.99678804
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76613634
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65013850
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64501914
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.62380067
9EWS_26573619_Chip-Seq_HEK293_Human2.57547439
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40257190
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39103927
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21153873
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18838523
14GBX2_23144817_ChIP-Seq_PC3_Human2.18216608
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.17899188
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.10944531
17FUS_26573619_Chip-Seq_HEK293_Human2.05458504
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98635742
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98196381
20FOXM1_23109430_ChIP-Seq_U2OS_Human1.91014766
21TAF15_26573619_Chip-Seq_HEK293_Human1.90256738
22ER_23166858_ChIP-Seq_MCF-7_Human1.84706164
23P300_19829295_ChIP-Seq_ESCs_Human1.80732718
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.80440310
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.77700088
26MYC_18940864_ChIP-ChIP_HL60_Human1.77458757
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74409588
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73745203
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65302919
30ELK1_19687146_ChIP-ChIP_HELA_Human1.63787977
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.63366994
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58661570
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57305838
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55768815
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55163543
36IGF1R_20145208_ChIP-Seq_DFB_Human1.54027778
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53849678
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.50635969
39VDR_23849224_ChIP-Seq_CD4+_Human1.48288808
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47591756
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46143836
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.44823006
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40032079
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36654203
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36654203
46BCAT_22108803_ChIP-Seq_LS180_Human1.33021857
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.32070287
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31127794
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30675837
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29996436
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29896766
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28835143
53RNF2_27304074_Chip-Seq_NSC_Mouse1.28720805
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27248354
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.27248354
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26794850
57TP53_22573176_ChIP-Seq_HFKS_Human1.26451990
58RUNX2_22187159_ChIP-Seq_PCA_Human1.26175506
59IRF1_19129219_ChIP-ChIP_H3396_Human1.23939955
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.23104749
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.22215472
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21776461
63ETV1_20927104_ChIP-Seq_GIST48_Human1.19720833
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19659972
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19618803
66STAT3_23295773_ChIP-Seq_U87_Human1.19281553
67TCF4_23295773_ChIP-Seq_U87_Human1.19106434
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17720777
69E2F7_22180533_ChIP-Seq_HELA_Human1.16280866
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15655524
71CBP_20019798_ChIP-Seq_JUKART_Human1.15655524
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15449037
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14366623
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.14277286
75AR_25329375_ChIP-Seq_VCAP_Human1.13890886
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13193745
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10562881
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.10379645
79P53_22387025_ChIP-Seq_ESCs_Mouse1.09775036
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08983865
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08763914
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08186008
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07170130
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06739480
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06504788
86REST_21632747_ChIP-Seq_MESCs_Mouse1.05818988
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03737232
88RBPJ_21746931_ChIP-Seq_IB4_Human1.03166590
89CBX2_22325352_ChIP-Seq_293T-Rex_Human1.02789626
90PHF8_20622853_ChIP-Seq_HELA_Human1.02360332
91PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02106803
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.01907730
93SMAD4_21799915_ChIP-Seq_A2780_Human1.01667333
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99938448
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99207143
96SMAD4_21741376_ChIP-Seq_EPCs_Human0.98500626
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98379194
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97999172
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.96643817
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96533023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.17700121
2MP0003787_abnormal_imprinting3.17260866
3MP0006292_abnormal_olfactory_placode2.69681626
4MP0002102_abnormal_ear_morphology2.54218209
5MP0000569_abnormal_digit_pigmentation2.46749130
6MP0004885_abnormal_endolymph2.40545685
7MP0003880_abnormal_central_pattern2.25660777
8MP0005174_abnormal_tail_pigmentation2.22455506
9MP0002234_abnormal_pharynx_morphology2.07088248
10MP0002938_white_spotting2.05578414
11MP0002736_abnormal_nociception_after2.01486983
12MP0003283_abnormal_digestive_organ1.87664194
13MP0004147_increased_porphyrin_level1.86207378
14MP0008872_abnormal_physiological_respon1.84669363
15MP0005551_abnormal_eye_electrophysiolog1.83282051
16MP0004133_heterotaxia1.83113454
17MP0009745_abnormal_behavioral_response1.73158347
18MP0010094_abnormal_chromosome_stability1.71242629
19MP0000427_abnormal_hair_cycle1.71040818
20MP0001293_anophthalmia1.70587973
21MP0008995_early_reproductive_senescence1.68193394
22MP0001968_abnormal_touch/_nociception1.67355766
23MP0008789_abnormal_olfactory_epithelium1.66413341
24MP0009046_muscle_twitch1.66318197
25MP0004142_abnormal_muscle_tone1.64710991
26MP0006072_abnormal_retinal_apoptosis1.57686143
27MP0008057_abnormal_DNA_replication1.56386015
28MP0003646_muscle_fatigue1.56156195
29MP0002272_abnormal_nervous_system1.56011842
30MP0001485_abnormal_pinna_reflex1.55908269
31MP0001529_abnormal_vocalization1.54517816
32MP0003195_calcinosis1.53027311
33MP0008058_abnormal_DNA_repair1.52092234
34MP0003121_genomic_imprinting1.50097622
35MP0005253_abnormal_eye_physiology1.49176679
36MP0002837_dystrophic_cardiac_calcinosis1.46759153
37MP0003718_maternal_effect1.45747104
38MP0000631_abnormal_neuroendocrine_gland1.42734862
39MP0005389_reproductive_system_phenotype1.41879160
40MP0002160_abnormal_reproductive_system1.38685049
41MP0003693_abnormal_embryo_hatching1.37107596
42MP0005645_abnormal_hypothalamus_physiol1.36601505
43MP0002064_seizures1.36138025
44MP0002095_abnormal_skin_pigmentation1.35989443
45MP0008875_abnormal_xenobiotic_pharmacok1.35268846
46MP0001919_abnormal_reproductive_system1.34283398
47MP0001486_abnormal_startle_reflex1.31220243
48MP0005075_abnormal_melanosome_morpholog1.28615305
49MP0009697_abnormal_copulation1.27956338
50MP0003878_abnormal_ear_physiology1.26803519
51MP0005377_hearing/vestibular/ear_phenot1.26803519
52MP0005394_taste/olfaction_phenotype1.26445201
53MP0005499_abnormal_olfactory_system1.26445201
54MP0000372_irregular_coat_pigmentation1.24859771
55MP0002653_abnormal_ependyma_morphology1.24560672
56MP0000015_abnormal_ear_pigmentation1.24305846
57MP0000778_abnormal_nervous_system1.23824103
58MP0005423_abnormal_somatic_nervous1.22722927
59MP0001188_hyperpigmentation1.20781557
60MP0005671_abnormal_response_to1.19758578
61MP0005408_hypopigmentation1.19485280
62MP0001873_stomach_inflammation1.16597851
63MP0001986_abnormal_taste_sensitivity1.11618091
64MP0003111_abnormal_nucleus_morphology1.10356230
65MP0005386_behavior/neurological_phenoty1.08202073
66MP0004924_abnormal_behavior1.08202073
67MP0001929_abnormal_gametogenesis1.05466301
68MP0009379_abnormal_foot_pigmentation1.05110892
69MP0004043_abnormal_pH_regulation1.04525075
70MP0002210_abnormal_sex_determination1.01734928
71MP0001501_abnormal_sleep_pattern1.01656135
72MP0003698_abnormal_male_reproductive1.01523057
73MP0006276_abnormal_autonomic_nervous1.01377131
74MP0004742_abnormal_vestibular_system1.00160095
75MP0006036_abnormal_mitochondrial_physio0.97129803
76MP0002009_preneoplasia0.96616170
77MP0005083_abnormal_biliary_tract0.96270534
78MP0003786_premature_aging0.95877917
79MP0002572_abnormal_emotion/affect_behav0.94439323
80MP0000653_abnormal_sex_gland0.92363773
81MP0005646_abnormal_pituitary_gland0.91512314
82MP0002067_abnormal_sensory_capabilities0.89301220
83MP0003635_abnormal_synaptic_transmissio0.89192901
84MP0005084_abnormal_gallbladder_morpholo0.85070471
85MP0005410_abnormal_fertilization0.84522133
86MP0005636_abnormal_mineral_homeostasis0.84393146
87MP0001145_abnormal_male_reproductive0.83844698
88MP0002735_abnormal_chemical_nociception0.83471506
89MP0000955_abnormal_spinal_cord0.81227389
90MP0000647_abnormal_sebaceous_gland0.78196391
91MP0002638_abnormal_pupillary_reflex0.76486823
92MP0003937_abnormal_limbs/digits/tail_de0.76259918
93MP0002557_abnormal_social/conspecific_i0.74927810
94MP0003122_maternal_imprinting0.74809034
95MP0003119_abnormal_digestive_system0.72619360
96MP0005195_abnormal_posterior_eye0.72211262
97MP0005187_abnormal_penis_morphology0.70967554
98MP0005391_vision/eye_phenotype0.70614536
99MP0002229_neurodegeneration0.70260928
100MP0001119_abnormal_female_reproductive0.69532615

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.11559789
2Protruding tongue (HP:0010808)3.67000742
3Abnormality of midbrain morphology (HP:0002418)3.49902433
4Molar tooth sign on MRI (HP:0002419)3.49902433
5Hyperventilation (HP:0002883)3.36886723
6Pancreatic fibrosis (HP:0100732)3.25635315
7Nephronophthisis (HP:0000090)3.21379170
8Acute necrotizing encephalopathy (HP:0006965)2.94073244
9Mitochondrial inheritance (HP:0001427)2.80932768
10Abnormality of alanine metabolism (HP:0010916)2.76538619
11Hyperalaninemia (HP:0003348)2.76538619
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.76538619
13Abnormality of the renal medulla (HP:0100957)2.74934039
14Short middle phalanx of the 5th finger (HP:0004220)2.73837919
15Acute encephalopathy (HP:0006846)2.67524587
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67162084
17Increased CSF lactate (HP:0002490)2.66974780
18Gaze-evoked nystagmus (HP:0000640)2.57229311
19Aplasia/Hypoplasia of the uvula (HP:0010293)2.56019729
20Broad-based gait (HP:0002136)2.53435359
21Sclerocornea (HP:0000647)2.53068242
22Meckel diverticulum (HP:0002245)2.47053365
23Supernumerary spleens (HP:0009799)2.46134816
24Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.44168343
25Chromsome breakage (HP:0040012)2.43421018
26Abnormal mitochondria in muscle tissue (HP:0008316)2.43267626
27Abnormal biliary tract physiology (HP:0012439)2.43174772
28Bile duct proliferation (HP:0001408)2.43174772
29Tubular atrophy (HP:0000092)2.42493613
30Congenital, generalized hypertrichosis (HP:0004540)2.42150292
31True hermaphroditism (HP:0010459)2.41310207
32Fair hair (HP:0002286)2.40933757
33Small intestinal stenosis (HP:0012848)2.39914290
34Duodenal stenosis (HP:0100867)2.39914290
35Abnormality of the ileum (HP:0001549)2.39497197
36Increased hepatocellular lipid droplets (HP:0006565)2.37504616
37Chronic hepatic failure (HP:0100626)2.37439759
38Acanthocytosis (HP:0001927)2.35914704
39Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.35756900
40Medial flaring of the eyebrow (HP:0010747)2.35745690
41Progressive macrocephaly (HP:0004481)2.35464641
42Inability to walk (HP:0002540)2.34855502
43Rib fusion (HP:0000902)2.33437702
44Duplicated collecting system (HP:0000081)2.33426505
45Absent/shortened dynein arms (HP:0200106)2.33024747
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.33024747
47Concave nail (HP:0001598)2.32902627
48Birth length less than 3rd percentile (HP:0003561)2.27996934
49Febrile seizures (HP:0002373)2.26741007
50Abnormality of the phalanges of the 5th finger (HP:0004213)2.23983709
513-Methylglutaconic aciduria (HP:0003535)2.21246471
52Abnormal lung lobation (HP:0002101)2.20993581
53Lipid accumulation in hepatocytes (HP:0006561)2.19322022
54Cerebral edema (HP:0002181)2.13899172
55Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.12909113
56Abnormality of the renal collecting system (HP:0004742)2.11707388
57Hypoplastic iliac wings (HP:0002866)2.10757982
58Type II lissencephaly (HP:0007260)2.09880002
59Abnormality of chromosome stability (HP:0003220)2.09576587
60Hepatocellular necrosis (HP:0001404)2.09576243
61Tinnitus (HP:0000360)2.09339986
62Abnormality of the renal cortex (HP:0011035)2.08154656
63Pendular nystagmus (HP:0012043)2.07804325
64Homocystinuria (HP:0002156)2.05678151
65Abnormality of homocysteine metabolism (HP:0010919)2.05678151
66Abnormality of the labia minora (HP:0012880)2.02877121
67Drooling (HP:0002307)2.02454775
68Abnormal drinking behavior (HP:0030082)2.01999676
69Polydipsia (HP:0001959)2.01999676
70Small hand (HP:0200055)2.00469430
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.99640688
72Abnormality of the carotid arteries (HP:0005344)1.97133760
73Gait imbalance (HP:0002141)1.95441864
74Patellar aplasia (HP:0006443)1.95341648
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94009416
76Clumsiness (HP:0002312)1.93365459
77Abnormality of the duodenum (HP:0002246)1.90843872
78Abnormality of the preputium (HP:0100587)1.90296959
79Absent thumb (HP:0009777)1.90139323
80Aganglionic megacolon (HP:0002251)1.88027017
81Male pseudohermaphroditism (HP:0000037)1.87353027
82Genital tract atresia (HP:0001827)1.85468558
83Attenuation of retinal blood vessels (HP:0007843)1.83892052
84Congenital primary aphakia (HP:0007707)1.82886339
85Vaginal atresia (HP:0000148)1.82160681
86Aplasia/Hypoplasia of the patella (HP:0006498)1.80852992
87Complete atrioventricular canal defect (HP:0001674)1.79864594
88Volvulus (HP:0002580)1.79791333
89Excessive salivation (HP:0003781)1.79612797
90Sloping forehead (HP:0000340)1.79214776
91Abnormality of DNA repair (HP:0003254)1.78905042
92Bilateral sensorineural hearing impairment (HP:0008619)1.77453567
93Ectopic kidney (HP:0000086)1.75922252
94Optic disc pallor (HP:0000543)1.75774233
95Dandy-Walker malformation (HP:0001305)1.75727156
96Exotropia (HP:0000577)1.75480237
97Clubbing of toes (HP:0100760)1.75359928
98Cystic liver disease (HP:0006706)1.75313836
99Severe combined immunodeficiency (HP:0004430)1.73984762
100Progressive microcephaly (HP:0000253)1.73432280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.65983511
2SIK23.35045341
3MAP4K23.06180305
4ZAK2.87954614
5PLK42.76303724
6FRK2.63607442
7WEE12.45685010
8TLK12.42260243
9VRK22.37151784
10BUB12.14742906
11MKNK22.10586045
12MAPK131.99318836
13ADRBK21.99217598
14NTRK31.92203967
15TRIM281.83293224
16WNK31.82730379
17EIF2AK31.76153567
18NTRK21.67414278
19NEK21.66873410
20CASK1.64726854
21MAP3K41.60595984
22STK161.59296620
23ACVR1B1.52449882
24CCNB11.47311642
25VRK11.42676413
26PINK11.37761126
27GRK11.36360186
28WNK41.33491169
29BMPR1B1.32740954
30CHEK21.32420329
31TNIK1.30477124
32EIF2AK21.27288276
33BCR1.26242443
34BRSK21.21884296
35PLK11.20432131
36MAP3K91.17210331
37TTK1.17197756
38MARK11.15650391
39PASK1.14369033
40PLK21.14144422
41MKNK11.12576467
42PLK31.08056848
43CDC71.05273917
44RAF11.02475773
45MUSK0.99103060
46STK30.94373213
47ATR0.93521246
48ERBB30.90021000
49DYRK20.88589377
50ADRBK10.87477841
51TYRO30.87325951
52PDK20.86212349
53MAP2K70.85794913
54DMPK0.83712383
55PRKCG0.78689287
56OXSR10.78368310
57TAF10.76807420
58PIK3CA0.75038900
59GRK60.73685558
60PTK2B0.70296783
61BCKDK0.67636979
62PNCK0.67452355
63INSRR0.66815534
64MST40.64103046
65ATM0.63092051
66MARK30.62195195
67TAOK30.56977499
68TXK0.55064042
69YES10.54788967
70CDK10.53673723
71SRPK10.52485520
72NEK90.50451667
73STK390.48143630
74PHKG20.46458159
75PHKG10.46458159
76PKN10.44785464
77CSNK1G20.44665870
78EIF2AK10.43152988
79CAMKK20.43041302
80CSNK1G30.42274269
81CSNK1D0.42236556
82PRKCQ0.40810458
83PRKAA10.40752655
84PAK30.39375013
85DYRK30.38276407
86RPS6KA50.38194769
87AURKB0.37593325
88CSNK1E0.37263263
89TEC0.36623752
90NME10.35425367
91SYK0.35218622
92CSNK1G10.34581650
93MAP2K20.33166239
94CAMK2A0.32246112
95PRKACA0.30247652
96PRKDC0.29824020
97PRKG10.29794279
98CHEK10.29554208
99PIK3CG0.27379888
100ALK0.27258842

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.64167624
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.15888876
3Protein export_Homo sapiens_hsa030603.01806372
4Oxidative phosphorylation_Homo sapiens_hsa001902.78533916
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73570491
6Selenocompound metabolism_Homo sapiens_hsa004502.61512575
7Fanconi anemia pathway_Homo sapiens_hsa034602.59652703
8Basal transcription factors_Homo sapiens_hsa030222.48587280
9Linoleic acid metabolism_Homo sapiens_hsa005912.44905157
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15201398
11Parkinsons disease_Homo sapiens_hsa050122.09537962
12RNA degradation_Homo sapiens_hsa030182.04601884
13Non-homologous end-joining_Homo sapiens_hsa034502.02998259
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99819723
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95587640
16Butanoate metabolism_Homo sapiens_hsa006501.94968364
17RNA polymerase_Homo sapiens_hsa030201.91903270
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91567271
19Nicotine addiction_Homo sapiens_hsa050331.88290377
20One carbon pool by folate_Homo sapiens_hsa006701.75618371
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72814787
22Caffeine metabolism_Homo sapiens_hsa002321.64209877
23Cardiac muscle contraction_Homo sapiens_hsa042601.61721030
24Huntingtons disease_Homo sapiens_hsa050161.60289240
25Olfactory transduction_Homo sapiens_hsa047401.58007089
26Ether lipid metabolism_Homo sapiens_hsa005651.54328982
27Mismatch repair_Homo sapiens_hsa034301.53012430
28Alzheimers disease_Homo sapiens_hsa050101.50413231
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48346270
30Taste transduction_Homo sapiens_hsa047421.48131672
31RNA transport_Homo sapiens_hsa030131.41500672
32Tryptophan metabolism_Homo sapiens_hsa003801.39120876
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36827293
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31337836
35DNA replication_Homo sapiens_hsa030301.26399195
36Proteasome_Homo sapiens_hsa030501.20334121
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18144742
38Steroid biosynthesis_Homo sapiens_hsa001001.16067968
39Phototransduction_Homo sapiens_hsa047441.14261591
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12133968
41Nucleotide excision repair_Homo sapiens_hsa034201.03390231
42Nitrogen metabolism_Homo sapiens_hsa009100.95096242
43Propanoate metabolism_Homo sapiens_hsa006400.92371787
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88488973
45Purine metabolism_Homo sapiens_hsa002300.83250368
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.81259873
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81259832
48Fat digestion and absorption_Homo sapiens_hsa049750.80697630
49Spliceosome_Homo sapiens_hsa030400.80678612
50Arachidonic acid metabolism_Homo sapiens_hsa005900.79723862
51Morphine addiction_Homo sapiens_hsa050320.79426813
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.77598941
53Serotonergic synapse_Homo sapiens_hsa047260.76424102
54Retinol metabolism_Homo sapiens_hsa008300.76053324
55Pyrimidine metabolism_Homo sapiens_hsa002400.76051250
56Ribosome_Homo sapiens_hsa030100.72884824
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.72128282
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.71873031
59Vitamin digestion and absorption_Homo sapiens_hsa049770.69539645
60Chemical carcinogenesis_Homo sapiens_hsa052040.69144225
61p53 signaling pathway_Homo sapiens_hsa041150.68626202
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66564262
63Metabolic pathways_Homo sapiens_hsa011000.64375879
64Circadian entrainment_Homo sapiens_hsa047130.63489757
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63317996
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62641030
67Sulfur relay system_Homo sapiens_hsa041220.61646839
68Glutamatergic synapse_Homo sapiens_hsa047240.60325266
69Base excision repair_Homo sapiens_hsa034100.59305104
70Dopaminergic synapse_Homo sapiens_hsa047280.59055694
71Cell cycle_Homo sapiens_hsa041100.58386494
72GABAergic synapse_Homo sapiens_hsa047270.54847762
73Lysine degradation_Homo sapiens_hsa003100.53376757
74ABC transporters_Homo sapiens_hsa020100.52785085
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49792856
76Insulin secretion_Homo sapiens_hsa049110.48617003
77Glycerolipid metabolism_Homo sapiens_hsa005610.46202874
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45778952
79Asthma_Homo sapiens_hsa053100.44387832
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41765961
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41565334
82Sulfur metabolism_Homo sapiens_hsa009200.41394048
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.41152434
84Histidine metabolism_Homo sapiens_hsa003400.39402010
85Tyrosine metabolism_Homo sapiens_hsa003500.37485125
86Oocyte meiosis_Homo sapiens_hsa041140.36724489
87Collecting duct acid secretion_Homo sapiens_hsa049660.35220002
88mRNA surveillance pathway_Homo sapiens_hsa030150.34275868
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34014697
90Ovarian steroidogenesis_Homo sapiens_hsa049130.32947508
91Circadian rhythm_Homo sapiens_hsa047100.32695789
92Amphetamine addiction_Homo sapiens_hsa050310.30584049
93Fatty acid metabolism_Homo sapiens_hsa012120.29204193
94Basal cell carcinoma_Homo sapiens_hsa052170.28308907
95Cocaine addiction_Homo sapiens_hsa050300.27583828
96Hedgehog signaling pathway_Homo sapiens_hsa043400.27323125
97Sphingolipid metabolism_Homo sapiens_hsa006000.27240973
98beta-Alanine metabolism_Homo sapiens_hsa004100.25968439
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25474932
100Peroxisome_Homo sapiens_hsa041460.24460301

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