ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	5.10052490
2	negative regulation of multicellular organism growth (GO:0040015)	4.89298828
3	L-fucose catabolic process (GO:0042355)	4.58037425
4	fucose catabolic process (GO:0019317)	4.58037425
5	L-fucose metabolic process (GO:0042354)	4.58037425
6	tryptophan catabolic process (GO:0006569)	4.38059188
7	indole-containing compound catabolic process (GO:0042436)	4.38059188
8	indolalkylamine catabolic process (GO:0046218)	4.38059188
9	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.28905355
10	tryptophan metabolic process (GO:0006568)	4.27865755
11	indolalkylamine metabolic process (GO:0006586)	4.01845073
12	kynurenine metabolic process (GO:0070189)	3.81508766
13	sulfation (GO:0051923)	3.72336156
14	amino acid salvage (GO:0043102)	3.69728720
15	L-methionine salvage (GO:0071267)	3.69728720
16	L-methionine biosynthetic process (GO:0071265)	3.69728720
17	regulation of MHC class I biosynthetic process (GO:0045343)	3.67382714
18	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.62817095
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.55921871
20	sex differentiation (GO:0007548)	3.55491880
21	cellular ketone body metabolic process (GO:0046950)	3.54715276
22	regulation of establishment of cell polarity (GO:2000114)	3.54268704
23	response to pheromone (GO:0019236)	3.53760560
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.48043505
25	platelet dense granule organization (GO:0060155)	3.43928739
26	behavioral response to nicotine (GO:0035095)	3.43262797
27	DNA deamination (GO:0045006)	3.42853744
28	cytoplasmic mRNA processing body assembly (GO:0033962)	3.37160692
29	piRNA metabolic process (GO:0034587)	3.27900064
30	S-adenosylmethionine metabolic process (GO:0046500)	3.24071899
31	regulation of cilium movement (GO:0003352)	3.21368283
32	detection of light stimulus involved in sensory perception (GO:0050962)	3.15945237
33	detection of light stimulus involved in visual perception (GO:0050908)	3.15945237
34	ketone body metabolic process (GO:1902224)	3.14605549
35	respiratory chain complex IV assembly (GO:0008535)	3.12674349
36	axoneme assembly (GO:0035082)	3.11866979
37	regulation of action potential (GO:0098900)	3.10859743
38	protein localization to cilium (GO:0061512)	3.08052121
39	positive regulation of vasculogenesis (GO:2001214)	3.07816898
40	water-soluble vitamin biosynthetic process (GO:0042364)	3.03623724
41	amine catabolic process (GO:0009310)	3.03370648
42	cellular biogenic amine catabolic process (GO:0042402)	3.03370648
43	peptidyl-histidine modification (GO:0018202)	2.99206809
44	negative regulation of mast cell activation (GO:0033004)	2.98352353
45	branched-chain amino acid catabolic process (GO:0009083)	2.97822629
46	neural tube formation (GO:0001841)	2.97175252
47	regulation of hexokinase activity (GO:1903299)	2.96094796
48	regulation of glucokinase activity (GO:0033131)	2.96094796
49	cytochrome complex assembly (GO:0017004)	2.95239656
50	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.94630200
51	epithelial cilium movement (GO:0003351)	2.93500431
52	adenosine metabolic process (GO:0046085)	2.93338588
53	indole-containing compound metabolic process (GO:0042430)	2.90702127
54	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.90004691
55	methionine biosynthetic process (GO:0009086)	2.89141535
56	protein complex biogenesis (GO:0070271)	2.88113601
57	acrosome assembly (GO:0001675)	2.88069510
58	negative regulation of telomere maintenance (GO:0032205)	2.87273680
59	nucleoside diphosphate catabolic process (GO:0009134)	2.86815448
60	synaptic transmission, cholinergic (GO:0007271)	2.84834410
61	ADP metabolic process (GO:0046031)	2.80441748
62	cholesterol catabolic process (GO:0006707)	2.80057706
63	sterol catabolic process (GO:0016127)	2.80057706
64	mitochondrial respiratory chain complex assembly (GO:0033108)	2.74501747
65	gamma-aminobutyric acid transport (GO:0015812)	2.74291932
66	aromatic amino acid family catabolic process (GO:0009074)	2.71522652
67	dopamine transport (GO:0015872)	2.66171638
68	auditory receptor cell stereocilium organization (GO:0060088)	2.66000137
69	NAD biosynthetic process (GO:0009435)	2.64931296
70	multicellular organism reproduction (GO:0032504)	2.63052302
71	protein polyglutamylation (GO:0018095)	2.62909380
72	protein neddylation (GO:0045116)	2.62855857
73	aspartate family amino acid catabolic process (GO:0009068)	2.62718843
74	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.61499383
75	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.61499383
76	NADH dehydrogenase complex assembly (GO:0010257)	2.61499383
77	photoreceptor cell maintenance (GO:0045494)	2.60896806
78	DNA methylation involved in gamete generation (GO:0043046)	2.59527250
79	seminiferous tubule development (GO:0072520)	2.59487884
80	neuronal action potential propagation (GO:0019227)	2.58883432
81	bile acid biosynthetic process (GO:0006699)	2.56888613
82	lipid particle organization (GO:0034389)	2.56526497
83	estrogen biosynthetic process (GO:0006703)	2.56379168
84	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.55942286
85	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.55942286
86	ubiquinone biosynthetic process (GO:0006744)	2.53422838
87	preassembly of GPI anchor in ER membrane (GO:0016254)	2.53307386
88	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.51417276
89	regulation of vasculogenesis (GO:2001212)	2.51231783
90	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.50839349
91	termination of RNA polymerase III transcription (GO:0006386)	2.50839349
92	DNA demethylation (GO:0080111)	2.48857978
93	DNA double-strand break processing (GO:0000729)	2.48674219
94	cilium morphogenesis (GO:0060271)	2.48534105
95	benzene-containing compound metabolic process (GO:0042537)	2.47987197
96	kidney morphogenesis (GO:0060993)	2.47710657
97	rRNA catabolic process (GO:0016075)	2.45330554
98	male meiosis I (GO:0007141)	2.45328771
99	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.44930783
100	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.44930783

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.58735370
2	VDR_22108803_ChIP-Seq_LS180_Human	3.36470551
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.26552732
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.13579232
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.73516211
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.69130081
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.63603821
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61318148
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.56885606
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46871592
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38123615
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.34340083
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30782343
14	FUS_26573619_Chip-Seq_HEK293_Human	2.27860066
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.22071500
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.18834050
17	EWS_26573619_Chip-Seq_HEK293_Human	2.04313146
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99873681
19	BCAT_22108803_ChIP-Seq_LS180_Human	1.94983591
20	P300_19829295_ChIP-Seq_ESCs_Human	1.91658281
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91630616
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.87451896
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76771440
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.74447832
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.68712916
26	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.65607374
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64678825
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.64191641
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60756505
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59190985
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57609180
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57452744
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.57452744
34	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50975417
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49947239
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48974396
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.47415713
38	AR_25329375_ChIP-Seq_VCAP_Human	1.46375666
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43346771
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43346771
41	STAT3_23295773_ChIP-Seq_U87_Human	1.42924153
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42915914
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.42256296
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.39599277
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38984126
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38984126
47	TCF4_23295773_ChIP-Seq_U87_Human	1.38652302
48	EZH2_22144423_ChIP-Seq_EOC_Human	1.37940602
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.37845149
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.36435096
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.34629945
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.32462512
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32000985
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30832516
55	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.29819105
56	CDX2_22108803_ChIP-Seq_LS180_Human	1.28156625
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26641353
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25761382
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25272525
60	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.24264343
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24221311
62	AR_20517297_ChIP-Seq_VCAP_Human	1.24200180
63	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22842922
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22695351
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22185168
66	NCOR_22424771_ChIP-Seq_293T_Human	1.19384383
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.19233260
68	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.19225532
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19154923
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18506776
71	VDR_23849224_ChIP-Seq_CD4+_Human	1.18264348
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18225150
73	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.17782229
74	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.17418633
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17155253
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16719908
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16646612
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16235446
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14586944
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13796916
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11713969
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10752906
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10559333
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.10172290
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09138489
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08493411
87	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05447109
88	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.04271839
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.03546351
90	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03295580
91	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03295580
92	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02305775
93	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.01791602
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01755907
95	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01276624
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99850916
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99145521
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99049878
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97122186
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95561909

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.90862460
2	MP0008877_abnormal_DNA_methylation	2.93923631
3	MP0006072_abnormal_retinal_apoptosis	2.80328055
4	MP0003011_delayed_dark_adaptation	2.79784235
5	MP0001968_abnormal_touch/_nociception	2.76625246
6	MP0003252_abnormal_bile_duct	2.68850330
7	MP0001986_abnormal_taste_sensitivity	2.59390115
8	MP0000569_abnormal_digit_pigmentation	2.58878254
9	MP0002837_dystrophic_cardiac_calcinosis	2.46078727
10	MP0005646_abnormal_pituitary_gland	2.44278706
11	MP0002736_abnormal_nociception_after	2.37615802
12	MP0005253_abnormal_eye_physiology	2.33781156
13	MP0005551_abnormal_eye_electrophysiolog	2.32583538
14	MP0002138_abnormal_hepatobiliary_system	2.15074172
15	MP0002876_abnormal_thyroid_physiology	2.11332204
16	MP0002102_abnormal_ear_morphology	2.02432013
17	MP0009046_muscle_twitch	1.94065290
18	MP0004147_increased_porphyrin_level	1.91119442
19	MP0010386_abnormal_urinary_bladder	1.89738475
20	MP0004043_abnormal_pH_regulation	1.88568420
21	MP0001501_abnormal_sleep_pattern	1.87451312
22	MP0009745_abnormal_behavioral_response	1.85984556
23	MP0001984_abnormal_olfaction	1.81107157
24	MP0005084_abnormal_gallbladder_morpholo	1.80144262
25	MP0002638_abnormal_pupillary_reflex	1.72098160
26	MP0003787_abnormal_imprinting	1.67289908
27	MP0005075_abnormal_melanosome_morpholog	1.66247734
28	MP0000427_abnormal_hair_cycle	1.56920101
29	MP0003880_abnormal_central_pattern	1.53014034
30	MP0008875_abnormal_xenobiotic_pharmacok	1.47661812
31	MP0002272_abnormal_nervous_system	1.47093302
32	MP0005645_abnormal_hypothalamus_physiol	1.47045262
33	MP0001764_abnormal_homeostasis	1.43182992
34	MP0008058_abnormal_DNA_repair	1.42789937
35	MP0004885_abnormal_endolymph	1.41036812
36	MP0003718_maternal_effect	1.40995648
37	MP0006035_abnormal_mitochondrial_morpho	1.38569753
38	MP0001486_abnormal_startle_reflex	1.38415215
39	MP0006036_abnormal_mitochondrial_physio	1.36573315
40	MP0005410_abnormal_fertilization	1.35382594
41	MP0008872_abnormal_physiological_respon	1.34591074
42	MP0009697_abnormal_copulation	1.28558221
43	MP0005174_abnormal_tail_pigmentation	1.26961973
44	MP0000372_irregular_coat_pigmentation	1.24414553
45	MP0002938_white_spotting	1.22714557
46	MP0000631_abnormal_neuroendocrine_gland	1.21759838
47	MP0002733_abnormal_thermal_nociception	1.20117577
48	MP0003186_abnormal_redox_activity	1.20074564
49	MP0006276_abnormal_autonomic_nervous	1.17912513
50	MP0002160_abnormal_reproductive_system	1.14742200
51	MP0005386_behavior/neurological_phenoty	1.10548007
52	MP0004924_abnormal_behavior	1.10548007
53	MP0002693_abnormal_pancreas_physiology	1.10545864
54	MP0001905_abnormal_dopamine_level	1.10139471
55	MP0002234_abnormal_pharynx_morphology	1.08078998
56	MP0002909_abnormal_adrenal_gland	1.07699621
57	MP0002928_abnormal_bile_duct	1.06973106
58	MP0001970_abnormal_pain_threshold	1.06428920
59	MP0006054_spinal_hemorrhage	1.06089222
60	MP0003646_muscle_fatigue	1.01889818
61	MP0005389_reproductive_system_phenotype	1.01435965
62	MP0002064_seizures	1.00221085
63	MP0004215_abnormal_myocardial_fiber	0.99958067
64	MP0002572_abnormal_emotion/affect_behav	0.99796264
65	MP0004142_abnormal_muscle_tone	0.99788187
66	MP0005332_abnormal_amino_acid	0.99747870
67	MP0005379_endocrine/exocrine_gland_phen	0.97812948
68	MP0008995_early_reproductive_senescence	0.96429526
69	MP0006292_abnormal_olfactory_placode	0.96393568
70	MP0003121_genomic_imprinting	0.94194568
71	MP0000516_abnormal_urinary_system	0.93967751
72	MP0005367_renal/urinary_system_phenotyp	0.93967751
73	MP0005636_abnormal_mineral_homeostasis	0.92403541
74	MP0001485_abnormal_pinna_reflex	0.91388224
75	MP0000653_abnormal_sex_gland	0.89905068
76	MP0005360_urolithiasis	0.89515570
77	MP0003786_premature_aging	0.88680571
78	MP0002735_abnormal_chemical_nociception	0.87367312
79	MP0002067_abnormal_sensory_capabilities	0.86555959
80	MP0005085_abnormal_gallbladder_physiolo	0.85367872
81	MP0005171_absent_coat_pigmentation	0.83189657
82	MP0003137_abnormal_impulse_conducting	0.83087764
83	MP0001756_abnormal_urination	0.83020790
84	MP0008775_abnormal_heart_ventricle	0.82452040
85	MP0002229_neurodegeneration	0.81383027
86	MP0003698_abnormal_male_reproductive	0.81382590
87	MP0000371_diluted_coat_color	0.80700390
88	MP0002557_abnormal_social/conspecific_i	0.79727090
89	MP0008789_abnormal_olfactory_epithelium	0.78975839
90	MP0002751_abnormal_autonomic_nervous	0.78134206
91	MP0003950_abnormal_plasma_membrane	0.77982503
92	MP0005647_abnormal_sex_gland	0.77974073
93	MP0010329_abnormal_lipoprotein_level	0.76162129
94	MP0001324_abnormal_eye_pigmentation	0.74582105
95	MP0000230_abnormal_systemic_arterial	0.73401062
96	MP0005391_vision/eye_phenotype	0.71887453
97	MP0001145_abnormal_male_reproductive	0.71867980
98	MP0005167_abnormal_blood-brain_barrier	0.71050061
99	MP0001929_abnormal_gametogenesis	0.70962713
100	MP0004145_abnormal_muscle_electrophysio	0.70564401

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.75052477
2	Progressive cerebellar ataxia (HP:0002073)	4.16577199
3	Pancreatic cysts (HP:0001737)	4.12677371
4	Gaze-evoked nystagmus (HP:0000640)	3.85179418
5	Pancreatic fibrosis (HP:0100732)	3.51660574
6	True hermaphroditism (HP:0010459)	3.48107368
7	Molar tooth sign on MRI (HP:0002419)	3.37474640
8	Abnormality of midbrain morphology (HP:0002418)	3.37474640
9	Congenital stationary night blindness (HP:0007642)	3.33351617
10	Nephronophthisis (HP:0000090)	3.24537136
11	Abnormality of the renal cortex (HP:0011035)	3.14683846
12	Pendular nystagmus (HP:0012043)	3.14598173
13	Prostate neoplasm (HP:0100787)	3.13471850
14	Medial flaring of the eyebrow (HP:0010747)	3.03261017
15	Abnormality of the renal medulla (HP:0100957)	2.94924189
16	Hypothermia (HP:0002045)	2.90017679
17	Action tremor (HP:0002345)	2.89319524
18	Fair hair (HP:0002286)	2.88627786
19	Abolished electroretinogram (ERG) (HP:0000550)	2.70932796
20	Type II lissencephaly (HP:0007260)	2.67893896
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.66381011
22	Polydipsia (HP:0001959)	2.66103566
23	Abnormal drinking behavior (HP:0030082)	2.66103566
24	Keratoconus (HP:0000563)	2.64372545
25	Increased corneal curvature (HP:0100692)	2.64372545
26	Hypoplasia of the fovea (HP:0007750)	2.64222693
27	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.64222693
28	Attenuation of retinal blood vessels (HP:0007843)	2.61161435
29	Hyperventilation (HP:0002883)	2.48980259
30	Focal motor seizures (HP:0011153)	2.46419665
31	Renal cortical cysts (HP:0000803)	2.46103382
32	Hypoproteinemia (HP:0003075)	2.44896093
33	Abnormality of the prostate (HP:0008775)	2.41765114
34	Tubular atrophy (HP:0000092)	2.40349791
35	Abnormality of macular pigmentation (HP:0008002)	2.39889911
36	Absence seizures (HP:0002121)	2.38482330
37	Dialeptic seizures (HP:0011146)	2.37983604
38	Focal seizures (HP:0007359)	2.37555757
39	Acute necrotizing encephalopathy (HP:0006965)	2.32783571
40	Dysdiadochokinesis (HP:0002075)	2.28231266
41	Chronic hepatic failure (HP:0100626)	2.28136476
42	Progressive macrocephaly (HP:0004481)	2.27443981
43	Cystic liver disease (HP:0006706)	2.25627195
44	Polyuria (HP:0000103)	2.25593388
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.23028385
46	Abnormality of alanine metabolism (HP:0010916)	2.23028385
47	Hyperalaninemia (HP:0003348)	2.23028385
48	Broad-based gait (HP:0002136)	2.22501686
49	Hemiparesis (HP:0001269)	2.19848425
50	Acute encephalopathy (HP:0006846)	2.19172609
51	Abnormality of the fovea (HP:0000493)	2.18920751
52	Mitochondrial inheritance (HP:0001427)	2.18042199
53	Generalized hypopigmentation of hair (HP:0011358)	2.17586354
54	Thyroiditis (HP:0100646)	2.17567100
55	Increased CSF lactate (HP:0002490)	2.16207271
56	Disproportionate short-trunk short stature (HP:0003521)	2.15399244
57	Stomach cancer (HP:0012126)	2.11503061
58	Congenital primary aphakia (HP:0007707)	2.09929684
59	Nephrogenic diabetes insipidus (HP:0009806)	2.09780473
60	Hepatocellular necrosis (HP:0001404)	2.08551935
61	Hepatic necrosis (HP:0002605)	2.07007317
62	Congenital, generalized hypertrichosis (HP:0004540)	2.06903964
63	Concave nail (HP:0001598)	2.05803801
64	Gait imbalance (HP:0002141)	2.05702496
65	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05127916
66	Absent/shortened dynein arms (HP:0200106)	2.01734867
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01734867
68	Protruding tongue (HP:0010808)	2.01593586
69	Abnormality of the hepatic vasculature (HP:0006707)	2.00781537
70	Sclerocornea (HP:0000647)	1.98253588
71	Dysmetric saccades (HP:0000641)	1.97992519
72	Hypoplasia of the uterus (HP:0000013)	1.97718822
73	Febrile seizures (HP:0002373)	1.96953476
74	Large for gestational age (HP:0001520)	1.95261502
75	Optic disc pallor (HP:0000543)	1.94897124
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.94692856
77	Decreased central vision (HP:0007663)	1.94488877
78	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93902475
79	Oculomotor apraxia (HP:0000657)	1.93380266
80	Chorioretinal atrophy (HP:0000533)	1.93253773
81	Bile duct proliferation (HP:0001408)	1.92171917
82	Abnormal biliary tract physiology (HP:0012439)	1.92171917
83	Retinitis pigmentosa (HP:0000510)	1.91908398
84	Lissencephaly (HP:0001339)	1.91885086
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.91646622
86	Intestinal atresia (HP:0011100)	1.91588044
87	Male pseudohermaphroditism (HP:0000037)	1.91370942
88	Congenital hepatic fibrosis (HP:0002612)	1.90416030
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.90216597
90	Abnormal mitochondria in muscle tissue (HP:0008316)	1.87830745
91	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87775578
92	3-Methylglutaconic aciduria (HP:0003535)	1.87003566
93	Absent speech (HP:0001344)	1.86671585
94	Inability to walk (HP:0002540)	1.85282613
95	Hyperglycinemia (HP:0002154)	1.83330000
96	Urinary bladder sphincter dysfunction (HP:0002839)	1.82377819
97	Severe visual impairment (HP:0001141)	1.81724847
98	Furrowed tongue (HP:0000221)	1.79287082
99	Progressive inability to walk (HP:0002505)	1.78515813
100	Widely spaced teeth (HP:0000687)	1.78380383

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.83950221
2	BMPR1B	3.80211935
3	MAP4K2	3.58472601
4	CDK19	3.42980974
5	PINK1	3.37660467
6	ZAK	3.07696737
7	OXSR1	2.88427706
8	NUAK1	2.81987446
9	GRK1	2.61523436
10	ADRBK2	2.11685782
11	ACVR1B	2.07961863
12	BCKDK	2.07051921
13	WNK3	2.05933985
14	TXK	1.72805792
15	MKNK2	1.68075068
16	STK38L	1.63863015
17	TGFBR1	1.50310078
18	FGFR2	1.43941984
19	MKNK1	1.39428979
20	CASK	1.35848984
21	TLK1	1.28694202
22	TRIM28	1.28032893
23	TAOK3	1.25608224
24	PLK2	1.22933677
25	WNK4	1.15741287
26	MST4	1.15542186
27	STK3	1.15382970
28	ERBB3	1.11083237
29	CSNK1G3	1.08921185
30	CSNK1G1	1.06394307
31	INSRR	1.05852701
32	BCR	1.04978225
33	CSNK1G2	1.04053545
34	FLT3	1.03599586
35	TNK2	1.03383823
36	MAPK13	1.02924347
37	KIT	1.02696730
38	CSNK1A1L	1.01656647
39	VRK1	1.00177198
40	PHKG2	0.96282311
41	PHKG1	0.96282311
42	TAF1	0.92549753
43	TNIK	0.90760948
44	TIE1	0.88990689
45	STK39	0.88209994
46	PRKCE	0.83347807
47	MAP3K4	0.83003846
48	CDK8	0.79807461
49	VRK2	0.78306082
50	MAPKAPK5	0.76914333
51	ADRBK1	0.76816198
52	NTRK3	0.74520244
53	PLK3	0.72503820
54	PAK3	0.71818245
55	BRSK2	0.70222756
56	EIF2AK3	0.68940848
57	TEC	0.67852585
58	NLK	0.66597552
59	PRKCG	0.64838614
60	FER	0.63379172
61	CAMKK2	0.62775242
62	MAPKAPK3	0.62184413
63	PIK3CA	0.61995385
64	PRKCQ	0.58149376
65	LATS1	0.57332956
66	EPHA4	0.55360676
67	MAP3K7	0.54286837
68	DAPK2	0.53569142
69	GRK5	0.50348194
70	IKBKB	0.50230693
71	RPS6KA5	0.50127638
72	PIK3CG	0.49010351
73	MAP2K6	0.47266862
74	PTK2B	0.47144756
75	CSNK1A1	0.46228793
76	OBSCN	0.45666855
77	ITK	0.45431333
78	CDK3	0.43487411
79	DYRK2	0.42965172
80	PRKCI	0.42862222
81	AKT3	0.42482400
82	STK11	0.42196435
83	MAP2K7	0.41288892
84	PASK	0.40817767
85	IRAK2	0.36861622
86	PRKG1	0.33655915
87	CAMK2A	0.33226403
88	PLK4	0.31915552
89	PRKACA	0.31576707
90	CHUK	0.30770911
91	CSNK1D	0.29877150
92	ABL1	0.27133177
93	ATM	0.26673380
94	MUSK	0.26585367
95	PRKCA	0.26569386
96	PRKAA1	0.25812217
97	PRKACB	0.22312007
98	CDK9	0.22268154
99	STK38	0.21667582
100	PRKAA2	0.21595436

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.22153911
2	Phototransduction_Homo sapiens_hsa04744	2.65690079
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.43018873
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.41067408
5	Butanoate metabolism_Homo sapiens_hsa00650	2.28305468
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15832646
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.12209536
8	Caffeine metabolism_Homo sapiens_hsa00232	2.12021545
9	RNA polymerase_Homo sapiens_hsa03020	2.09016022
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.02201351
11	Propanoate metabolism_Homo sapiens_hsa00640	2.00881680
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00241997
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.96276251
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95949037
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.84782931
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.83800705
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.81478679
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.80899900
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69271120
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.68893683
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68640132
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.65619603
23	Basal transcription factors_Homo sapiens_hsa03022	1.65145483
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64226369
25	Protein export_Homo sapiens_hsa03060	1.56731682
26	Olfactory transduction_Homo sapiens_hsa04740	1.56076554
27	Peroxisome_Homo sapiens_hsa04146	1.52370084
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.50966073
29	Homologous recombination_Homo sapiens_hsa03440	1.44569463
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.42484226
31	Asthma_Homo sapiens_hsa05310	1.37419541
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.35646467
33	Parkinsons disease_Homo sapiens_hsa05012	1.29115196
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.28400745
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28151072
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.25154080
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.24623547
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.24459231
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23312767
40	Retinol metabolism_Homo sapiens_hsa00830	1.22846160
41	RNA degradation_Homo sapiens_hsa03018	1.22517703
42	Taste transduction_Homo sapiens_hsa04742	1.14711288
43	Purine metabolism_Homo sapiens_hsa00230	1.12374285
44	Nicotine addiction_Homo sapiens_hsa05033	1.11605441
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.08463886
46	Regulation of autophagy_Homo sapiens_hsa04140	1.06229538
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.03496887
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.01172677
49	Sulfur metabolism_Homo sapiens_hsa00920	0.99719217
50	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.98259240
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92647650
52	Salivary secretion_Homo sapiens_hsa04970	0.91230097
53	Graft-versus-host disease_Homo sapiens_hsa05332	0.90231310
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.88860017
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88711586
56	Allograft rejection_Homo sapiens_hsa05330	0.88401330
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87054588
58	Fatty acid elongation_Homo sapiens_hsa00062	0.86454116
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.86241571
60	Proteasome_Homo sapiens_hsa03050	0.85476772
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84262623
62	ABC transporters_Homo sapiens_hsa02010	0.81861583
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79514453
64	One carbon pool by folate_Homo sapiens_hsa00670	0.77996738
65	Morphine addiction_Homo sapiens_hsa05032	0.71300427
66	Circadian rhythm_Homo sapiens_hsa04710	0.70406168
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69629337
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68959385
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68909833
70	Metabolic pathways_Homo sapiens_hsa01100	0.67977961
71	Alzheimers disease_Homo sapiens_hsa05010	0.67349224
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.67327832
73	Circadian entrainment_Homo sapiens_hsa04713	0.66502044
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66415004
75	Huntingtons disease_Homo sapiens_hsa05016	0.64652242
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63311561
77	Serotonergic synapse_Homo sapiens_hsa04726	0.62904717
78	Insulin secretion_Homo sapiens_hsa04911	0.62538008
79	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.62414480
80	Fatty acid degradation_Homo sapiens_hsa00071	0.61676181
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58757151
82	GABAergic synapse_Homo sapiens_hsa04727	0.56187320
83	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.55973729
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55702824
85	Mineral absorption_Homo sapiens_hsa04978	0.54972483
86	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52463530
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.51902830
88	Primary immunodeficiency_Homo sapiens_hsa05340	0.50740519
89	Base excision repair_Homo sapiens_hsa03410	0.47557623
90	Renin secretion_Homo sapiens_hsa04924	0.47358499
91	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46007965
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42378132
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42197363
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.42064215
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.41467873
96	Cardiac muscle contraction_Homo sapiens_hsa04260	0.40431159
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37664020
98	Glutathione metabolism_Homo sapiens_hsa00480	0.35046050
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.34011528
100	Long-term depression_Homo sapiens_hsa04730	0.33412827

SUGT1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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