SULF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon extension involved in axon guidance (GO:0048846)7.66380370
2neuron projection extension involved in neuron projection guidance (GO:1902284)7.66380370
3lung epithelium development (GO:0060428)6.31978188
4negative regulation of axon guidance (GO:1902668)5.23857399
5cell proliferation involved in metanephros development (GO:0072203)5.21074334
6establishment of apical/basal cell polarity (GO:0035089)5.19211607
7glomerular epithelial cell development (GO:0072310)5.10548445
8G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.95377792
9establishment of tissue polarity (GO:0007164)4.80670558
10establishment of planar polarity (GO:0001736)4.80670558
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.76954863
12establishment or maintenance of monopolar cell polarity (GO:0061339)4.70890066
13establishment of monopolar cell polarity (GO:0061162)4.70890066
14regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.56997706
15dopaminergic neuron differentiation (GO:0071542)4.53905368
16paraxial mesoderm development (GO:0048339)4.52905061
17regulation of chemokine-mediated signaling pathway (GO:0070099)4.51197483
18positive regulation of tolerance induction (GO:0002645)4.49360636
19epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.47496317
20branching involved in salivary gland morphogenesis (GO:0060445)4.45957301
21negative chemotaxis (GO:0050919)4.41676344
22type B pancreatic cell proliferation (GO:0044342)4.40644295
23cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.40344018
24establishment of nucleus localization (GO:0040023)4.32102874
25retinal ganglion cell axon guidance (GO:0031290)4.25389015
26skin morphogenesis (GO:0043589)4.23247663
27endodermal cell differentiation (GO:0035987)4.21204182
28lateral sprouting from an epithelium (GO:0060601)4.20101178
29positive regulation of astrocyte differentiation (GO:0048711)4.18396004
30mesenchymal cell proliferation (GO:0010463)4.08349540
31collagen fibril organization (GO:0030199)4.02728808
32extracellular matrix assembly (GO:0085029)3.95365765
33dermatan sulfate biosynthetic process (GO:0030208)3.94574392
34negative regulation of humoral immune response (GO:0002921)3.93707627
35regulation of mesenchymal cell apoptotic process (GO:2001053)3.92820028
36cell proliferation involved in kidney development (GO:0072111)3.89727944
37negative regulation of axon extension involved in axon guidance (GO:0048843)3.85549047
38bone trabecula formation (GO:0060346)3.85376336
39regulation of axon guidance (GO:1902667)3.81923588
40collagen metabolic process (GO:0032963)3.76621995
41dermatan sulfate metabolic process (GO:0030205)3.73124649
42metanephric mesenchyme development (GO:0072075)3.73111398
43regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.73007779
44regulation of tolerance induction (GO:0002643)3.70647035
45collagen catabolic process (GO:0030574)3.69760070
46lung-associated mesenchyme development (GO:0060484)3.69576710
47negative regulation of T cell differentiation in thymus (GO:0033085)3.65886981
48kidney mesenchyme development (GO:0072074)3.65665542
49radial glial cell differentiation (GO:0060019)3.65435718
50negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.62633687
51negative regulation of leukocyte chemotaxis (GO:0002689)3.61870072
52artery development (GO:0060840)3.61596540
53mesenchyme morphogenesis (GO:0072132)3.61017743
54embryonic foregut morphogenesis (GO:0048617)3.60490789
55regulation of secondary heart field cardioblast proliferation (GO:0003266)3.60008753
56regulation of cardioblast proliferation (GO:0003264)3.60008753
57keratan sulfate catabolic process (GO:0042340)3.59193256
58lung lobe morphogenesis (GO:0060463)3.57940898
59positive regulation of gastrulation (GO:2000543)3.53583085
60multicellular organismal macromolecule metabolic process (GO:0044259)3.50794299
61* glomerular basement membrane development (GO:0032836)3.48049606
62negative regulation of B cell mediated immunity (GO:0002713)3.46435907
63negative regulation of immunoglobulin mediated immune response (GO:0002890)3.46435907
64regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.46182413
65negative regulation of chondrocyte differentiation (GO:0032331)3.44117031
66midbrain development (GO:0030901)3.44072286
67hippo signaling (GO:0035329)3.43281906
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.42789177
69endocardial cushion morphogenesis (GO:0003203)3.42421327
70peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.41775332
71cochlea morphogenesis (GO:0090103)3.40526769
72multicellular organismal catabolic process (GO:0044243)3.39749897
73regulation of establishment of planar polarity (GO:0090175)3.36474633
74ventricular septum development (GO:0003281)3.36144479
75camera-type eye morphogenesis (GO:0048593)3.35073310
76regulation of axon extension involved in axon guidance (GO:0048841)3.34646417
77* negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.32734080
78multicellular organismal metabolic process (GO:0044236)3.32708660
79neuronal stem cell maintenance (GO:0097150)3.32134996
80extracellular regulation of signal transduction (GO:1900115)3.28608682
81extracellular negative regulation of signal transduction (GO:1900116)3.28608682
82chondrocyte proliferation (GO:0035988)3.27999676
83cell surface receptor signaling pathway involved in heart development (GO:0061311)3.26733352
84blood vessel maturation (GO:0001955)3.26060935
85convergent extension (GO:0060026)3.24417627
86* chondrocyte development (GO:0002063)3.23817998
87sequestering of extracellular ligand from receptor (GO:0035581)3.23456973
88* regulation of organ formation (GO:0003156)3.23271518
89cell adhesion mediated by integrin (GO:0033627)3.22230527
90negative regulation of smooth muscle cell migration (GO:0014912)3.21573578
91neural crest cell development (GO:0014032)3.20111542
92primitive streak formation (GO:0090009)3.19646115
93extracellular matrix disassembly (GO:0022617)3.13918928
94dendritic spine morphogenesis (GO:0060997)3.12828613
95positive regulation of embryonic development (GO:0040019)3.12371576
96regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.11580947
97left/right pattern formation (GO:0060972)3.11135449
98axonal fasciculation (GO:0007413)3.10013814
99positive regulation of epithelial to mesenchymal transition (GO:0010718)3.09486917
100virion attachment to host cell (GO:0019062)3.08840084
101adhesion of symbiont to host cell (GO:0044650)3.08840084
102outer ear morphogenesis (GO:0042473)3.07717225
103cell migration involved in sprouting angiogenesis (GO:0002042)3.07711821
104regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.06479314
105mesenchymal-epithelial cell signaling (GO:0060638)3.06328990
106somite development (GO:0061053)3.05057094
107protein heterotrimerization (GO:0070208)3.04917000
108neuron fate determination (GO:0048664)3.04308437
109wound healing, spreading of epidermal cells (GO:0035313)3.03379619
110astrocyte differentiation (GO:0048708)3.03067877
111Notch signaling involved in heart development (GO:0061314)3.02507532
112embryonic hindlimb morphogenesis (GO:0035116)3.01593881
113cell migration involved in heart development (GO:0060973)3.01012488
114regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.98701678
115positive regulation of smoothened signaling pathway (GO:0045880)2.98253961
116smooth muscle tissue development (GO:0048745)2.98189207
117substrate-dependent cell migration (GO:0006929)2.97624595
118notochord development (GO:0030903)2.97305378
119vascular endothelial growth factor signaling pathway (GO:0038084)2.97173307
120non-canonical Wnt signaling pathway (GO:0035567)2.97095161
121negative regulation of axon extension (GO:0030517)2.96491115
122limb bud formation (GO:0060174)2.94246471
123fibril organization (GO:0097435)2.93085511
124* extracellular matrix organization (GO:0030198)2.92285514
125striated muscle cell proliferation (GO:0014855)2.92084165
126hindlimb morphogenesis (GO:0035137)2.91776826
127* extracellular structure organization (GO:0043062)2.91540703
128* positive regulation of BMP signaling pathway (GO:0030513)2.91373073
129pericardium development (GO:0060039)2.90661286
130endocardial cushion development (GO:0003197)2.90117682
131craniofacial suture morphogenesis (GO:0097094)2.89261445
132* negative regulation of embryonic development (GO:0045992)2.88284766
133epithelial cell differentiation involved in prostate gland development (GO:0060742)2.87810388
134negative regulation of osteoblast proliferation (GO:0033689)2.87789903
135regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.87373568
136* glomerular filtration (GO:0003094)2.84182305
137endothelial cell morphogenesis (GO:0001886)2.83253483
138positive regulation of mesenchymal cell proliferation (GO:0002053)2.82736120
139regulation of mesoderm development (GO:2000380)2.82549072
140face development (GO:0060324)2.82115982
141extracellular fibril organization (GO:0043206)2.81750360
142establishment or maintenance of bipolar cell polarity (GO:0061245)2.81631160
143establishment or maintenance of apical/basal cell polarity (GO:0035088)2.81631160
144nucleus localization (GO:0051647)2.80734488
145renal system development (GO:0072001)2.80611890
146negative regulation of BMP signaling pathway (GO:0030514)2.78986775
147chondroitin sulfate biosynthetic process (GO:0030206)2.78842079
148artery morphogenesis (GO:0048844)2.78160217
149regulation of chondrocyte differentiation (GO:0032330)2.77808096
150cartilage condensation (GO:0001502)2.75595653
151cell aggregation (GO:0098743)2.75595653
152regulation of cartilage development (GO:0061035)2.72233862
153negative regulation of cartilage development (GO:0061037)2.69926658
154substrate adhesion-dependent cell spreading (GO:0034446)2.67547520
155regulation of timing of cell differentiation (GO:0048505)2.66415352
156venous blood vessel morphogenesis (GO:0048845)2.66179803
157lymphangiogenesis (GO:0001946)2.64896538
158cardiac septum development (GO:0003279)2.64275914
159axon extension (GO:0048675)2.63834633
160positive regulation of cartilage development (GO:0061036)2.61107542
161cell-cell signaling involved in cell fate commitment (GO:0045168)2.59169649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.05111209
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.48125191
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.40338591
4EED_16625203_ChIP-ChIP_MESCs_Mouse3.02058853
5* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.99974705
6PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.83639434
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.78496447
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.66569888
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.49371118
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.40201495
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36648627
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36648627
13RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.36032118
14* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35402142
15TP53_20018659_ChIP-ChIP_R1E_Mouse2.34937191
16E2F7_22180533_ChIP-Seq_HELA_Human2.28362592
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.26653306
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24805792
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.24791060
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19003496
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17527200
22EZH2_22144423_ChIP-Seq_EOC_Human2.13958390
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.13224451
24* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.03011678
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.01812566
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.99424435
27* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.93349704
28* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.93349704
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89093888
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85793580
31* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.84002441
32CLOCK_20551151_ChIP-Seq_293T_Human1.83581085
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81329283
34GBX2_23144817_ChIP-Seq_PC3_Human1.80606589
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78459824
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73084281
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72549938
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.71601644
39* ISL1_27105846_Chip-Seq_CPCs_Mouse1.69596192
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68962505
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67296544
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67281424
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65852498
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65611195
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65157115
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63703861
47ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59172761
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58421118
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58304875
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57136923
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56962875
52CJUN_26792858_Chip-Seq_BT549_Human1.55859264
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52951233
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52696796
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51359797
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.50661655
57* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49982624
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.45930574
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45585693
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44315649
61* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.44291237
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43768291
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42669985
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.40831530
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.39711720
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.39470970
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.39350897
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36151532
69* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36082002
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36075864
71* BRD4_25478319_ChIP-Seq_HGPS_Human1.34657469
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.34133058
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32724908
74TP53_16413492_ChIP-PET_HCT116_Human1.31961823
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.29752773
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29709122
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29155436
78* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.27492622
79* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26374275
80* SOX2_16153702_ChIP-ChIP_HESCs_Human1.24596057
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21355225
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18416410
83SA1_22415368_ChIP-Seq_MEFs_Mouse1.18215049
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17832521
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17180231
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.15052004
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14766609
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13727850
89TP53_18474530_ChIP-ChIP_U2OS_Human1.13192530
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12824795
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12262331
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12233020
93* NANOG_16153702_ChIP-ChIP_HESCs_Human1.11083601
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.10973960
95TP53_23651856_ChIP-Seq_MEFs_Mouse1.10173145
96* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09649755
97SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09628479
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.09246817
99AR_21909140_ChIP-Seq_LNCAP_Human1.09043415
100* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07980516
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07756459
102AHR_22903824_ChIP-Seq_MCF-7_Human1.07740075
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.06921787
104* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06882699
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06520432
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05782283
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05782283
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05782283
109* PIAS1_25552417_ChIP-Seq_VCAP_Human1.05284452
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.03657745
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02688218
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02295099
113MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01326349
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01241855
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00268239
116SMAD4_21799915_ChIP-Seq_A2780_Human1.00205155
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00046296
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99656369
119FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99251439
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98548264
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.98177057
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97853937
123* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97170347
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93782312
125SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93123097
126* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92137616
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91746794
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90833330
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90612089
130* KDM2B_26808549_Chip-Seq_REH_Human0.90611449
131BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90012149
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87941221
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86698619
134* P300_19829295_ChIP-Seq_ESCs_Human0.86550695
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.86276536
136* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85834324
137BCAT_22108803_ChIP-Seq_LS180_Human0.85612603
138* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84978632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.55398993
2MP0003283_abnormal_digestive_organ3.98892937
3MP0005503_abnormal_tendon_morphology3.65709614
4MP0000537_abnormal_urethra_morphology3.51403644
5MP0010030_abnormal_orbit_morphology3.49650899
6MP0009053_abnormal_anal_canal3.40001211
7MP0005275_abnormal_skin_tensile2.78284876
8MP0000566_synostosis2.66296485
9MP0003942_abnormal_urinary_system2.53323961
10MP0002282_abnormal_trachea_morphology2.52626774
11MP0002234_abnormal_pharynx_morphology2.49679641
12MP0004133_heterotaxia2.48594514
13MP0004272_abnormal_basement_membrane2.36853576
14MP0003122_maternal_imprinting2.34995987
15MP0001542_abnormal_bone_strength2.30538326
16MP0005623_abnormal_meninges_morphology2.04926917
17MP0002249_abnormal_larynx_morphology2.03257812
18MP0000534_abnormal_ureter_morphology1.95843657
19MP0003279_aneurysm1.92336917
20MP0000049_abnormal_middle_ear1.91857453
21MP0003705_abnormal_hypodermis_morpholog1.91255641
22MP0003385_abnormal_body_wall1.83356129
23MP0001293_anophthalmia1.82953395
24MP0003937_abnormal_limbs/digits/tail_de1.82169421
25MP0003115_abnormal_respiratory_system1.81689020
26MP0000428_abnormal_craniofacial_morphol1.80679602
27MP0009250_abnormal_appendicular_skeleto1.79364933
28MP0009384_cardiac_valve_regurgitation1.77963706
29MP0005076_abnormal_cell_differentiation1.75301016
30MP0002938_white_spotting1.73891149
31* MP0005508_abnormal_skeleton_morphology1.72475016
32MP0003950_abnormal_plasma_membrane1.72303608
33MP0001958_emphysema1.70354900
34* MP0002932_abnormal_joint_morphology1.68437019
35MP0001299_abnormal_eye_distance/1.63214253
36MP0003136_yellow_coat_color1.62999006
37MP0002102_abnormal_ear_morphology1.55301369
38MP0002108_abnormal_muscle_morphology1.53670156
39MP0003755_abnormal_palate_morphology1.45051598
40MP0000733_abnormal_muscle_development1.43935773
41MP0002233_abnormal_nose_morphology1.43846331
42MP0000013_abnormal_adipose_tissue1.40750934
43MP0003938_abnormal_ear_development1.36576858
44* MP0002116_abnormal_craniofacial_bone1.36482524
45MP0003941_abnormal_skin_development1.36267183
46MP0003315_abnormal_perineum_morphology1.33682131
47MP0006054_spinal_hemorrhage1.33530646
48MP0000462_abnormal_digestive_system1.33276803
49MP0003935_abnormal_craniofacial_develop1.32630045
50MP0001243_abnormal_dermal_layer1.31098215
51MP0002092_abnormal_eye_morphology1.30778168
52MP0002653_abnormal_ependyma_morphology1.30370341
53MP0004233_abnormal_muscle_weight1.28009232
54MP0003119_abnormal_digestive_system1.25127196
55MP0003091_abnormal_cell_migration1.24007743
56MP0000569_abnormal_digit_pigmentation1.23539107
57MP0010386_abnormal_urinary_bladder1.23222661
58MP0005257_abnormal_intraocular_pressure1.22813810
59* MP0000467_abnormal_esophagus_morphology1.22792544
60MP0000778_abnormal_nervous_system1.19939755
61MP0002697_abnormal_eye_size1.19864723
62MP0005595_abnormal_vascular_smooth1.19128391
63MP0003121_genomic_imprinting1.18462158
64* MP0000163_abnormal_cartilage_morphology1.16875814
65* MP0005390_skeleton_phenotype1.16356971
66MP0005023_abnormal_wound_healing1.13732262
67MP0002084_abnormal_developmental_patter1.13571959
68MP0004084_abnormal_cardiac_muscle1.13466985
69MP0001879_abnormal_lymphatic_vessel1.09189014
70MP0004858_abnormal_nervous_system1.08837962
71MP0002085_abnormal_embryonic_tissue1.08693726
72* MP0002111_abnormal_tail_morphology1.04491486
73MP0005084_abnormal_gallbladder_morpholo1.04327488
74* MP0000432_abnormal_head_morphology1.03771967
75MP0002896_abnormal_bone_mineralization1.01301405
76MP0000762_abnormal_tongue_morphology1.01251400
77MP0004197_abnormal_fetal_growth/weight/1.01057627
78MP0010352_gastrointestinal_tract_polyps1.00706010
79MP0005248_abnormal_Harderian_gland0.99798539
80* MP0002109_abnormal_limb_morphology0.99003559
81MP0000767_abnormal_smooth_muscle0.98847671
82MP0001348_abnormal_lacrimal_gland0.98651793
83MP0001286_abnormal_eye_development0.96703990
84MP0003861_abnormal_nervous_system0.96112763
85MP0003566_abnormal_cell_adhesion0.95938846
86MP0002177_abnormal_outer_ear0.95737412
87MP0002295_abnormal_pulmonary_circulatio0.95386239
88MP0003890_abnormal_embryonic-extraembry0.92814222
89MP0000383_abnormal_hair_follicle0.92736393
90* MP0002113_abnormal_skeleton_development0.90178137
91* MP0002115_abnormal_skeleton_extremities0.87025051
92MP0002133_abnormal_respiratory_system0.86690541
93MP0005388_respiratory_system_phenotype0.86690541
94MP0000751_myopathy0.86340016
95MP0002168_other_aberrant_phenotype0.86127696
96MP0004134_abnormal_chest_morphology0.85702573
97* MP0002114_abnormal_axial_skeleton0.84232401
98MP0005197_abnormal_uvea_morphology0.84177019
99MP0000749_muscle_degeneration0.80677291
100MP0000538_abnormal_urinary_bladder0.78226709
101MP0002089_abnormal_postnatal_growth/wei0.77984829
102MP0010368_abnormal_lymphatic_system0.77783407
103MP0000026_abnormal_inner_ear0.76719958
104MP0002928_abnormal_bile_duct0.75188564
105MP0000750_abnormal_muscle_regeneration0.72674433
106MP0002925_abnormal_cardiovascular_devel0.72273160
107MP0009780_abnormal_chondrocyte_physiolo0.72038443
108MP0001346_abnormal_lacrimal_gland0.71857530
109MP0002933_joint_inflammation0.71835145
110MP0008932_abnormal_embryonic_tissue0.70173937
111MP0003123_paternal_imprinting0.69617711
112MP0002128_abnormal_blood_circulation0.67897911
113* MP0002751_abnormal_autonomic_nervous0.66613418
114MP0005164_abnormal_response_to0.65821768
115MP0001340_abnormal_eyelid_morphology0.64525340
116MP0000647_abnormal_sebaceous_gland0.64278405
117MP0002060_abnormal_skin_morphology0.62896898
118MP0001175_abnormal_lung_morphology0.62664310
119MP0005171_absent_coat_pigmentation0.62545328
120MP0003137_abnormal_impulse_conducting0.62006774
121MP0002998_abnormal_bone_remodeling0.60978593
122MP0000266_abnormal_heart_morphology0.60926261
123MP0005193_abnormal_anterior_eye0.60611689
124MP0001614_abnormal_blood_vessel0.60594742
125MP0000759_abnormal_skeletal_muscle0.60058912
126* MP0003795_abnormal_bone_structure0.53349678
127MP0001177_atelectasis0.51620108
128MP0001270_distended_abdomen0.50700377
129MP0003448_altered_tumor_morphology0.50396149
130MP0000003_abnormal_adipose_tissue0.49385447
131MP0003300_gastrointestinal_ulcer0.49141804
132MP0000613_abnormal_salivary_gland0.47796757

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.56340847
2Premature rupture of membranes (HP:0001788)4.98698193
3Shallow orbits (HP:0000586)4.56785915
4Aortic dissection (HP:0002647)3.76830208
5Aortic aneurysm (HP:0004942)3.65525130
6Ankle contracture (HP:0006466)3.51999312
7Broad metatarsal (HP:0001783)3.48290123
8Follicular hyperkeratosis (HP:0007502)3.39298410
9Short 4th metacarpal (HP:0010044)3.33803888
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.33803888
11Type 1 muscle fiber predominance (HP:0003803)3.18414622
12Aortic regurgitation (HP:0001659)3.06068487
13Soft skin (HP:0000977)3.02260241
14Bilateral microphthalmos (HP:0007633)2.99618098
15Abnormality of the 4th metacarpal (HP:0010012)2.91676565
16Mesomelia (HP:0003027)2.91656747
17Wrist flexion contracture (HP:0001239)2.90811192
18Cerebral aneurysm (HP:0004944)2.88930987
19Blue sclerae (HP:0000592)2.87136195
20Bladder diverticulum (HP:0000015)2.80128822
21Dilatation of the ascending aorta (HP:0005111)2.79793313
22Abnormality of dentin (HP:0010299)2.75467624
23Abnormal number of incisors (HP:0011064)2.72344971
24Mitral valve prolapse (HP:0001634)2.71620259
25Peritonitis (HP:0002586)2.63300663
26Vascular tortuosity (HP:0004948)2.61907232
27Aortic valve stenosis (HP:0001650)2.58269641
28Atrophic scars (HP:0001075)2.57896463
29Neonatal short-limb short stature (HP:0008921)2.56102535
30Maternal diabetes (HP:0009800)2.54127145
31Arterial tortuosity (HP:0005116)2.52795706
32Anophthalmia (HP:0000528)2.51087841
33Mitral regurgitation (HP:0001653)2.50807832
34Absent frontal sinuses (HP:0002688)2.48905236
35Morphological abnormality of the middle ear (HP:0008609)2.46823064
36Renal duplication (HP:0000075)2.46174710
37Genu recurvatum (HP:0002816)2.45036552
38Deviation of the hallux (HP:0010051)2.43848485
39Wide anterior fontanel (HP:0000260)2.39582901
40Slender build (HP:0001533)2.36994180
41Coronal craniosynostosis (HP:0004440)2.34855559
42Wormian bones (HP:0002645)2.31978908
43Fragile skin (HP:0001030)2.29993045
44Hallux valgus (HP:0001822)2.29748744
45Broad thumb (HP:0011304)2.25641922
46Vertebral compression fractures (HP:0002953)2.25602040
47Broad long bones (HP:0005622)2.24164328
48Abnormal delivery (HP:0001787)2.23354808
49Increased corneal curvature (HP:0100692)2.23345563
50Keratoconus (HP:0000563)2.23345563
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22362675
52Bowel diverticulosis (HP:0005222)2.19532073
53Narrow nasal bridge (HP:0000446)2.17854900
54Short middle phalanx of the 5th finger (HP:0004220)2.15903065
55Broad phalanges of the hand (HP:0009768)2.13777575
56Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.13155023
57Femoral bowing (HP:0002980)2.11165576
58Broad ribs (HP:0000885)2.10999038
59Broad finger (HP:0001500)2.10176403
60Pulmonary artery stenosis (HP:0004415)2.10100440
61Abnormality of incisor morphology (HP:0011063)2.09776313
62Joint stiffness (HP:0001387)2.09137343
63Infantile muscular hypotonia (HP:0008947)2.09097655
64Round ear (HP:0100830)2.08623993
65Broad phalanx (HP:0006009)2.07856820
66Hypoventilation (HP:0002791)2.07181852
67Cervical subluxation (HP:0003308)2.07136144
68Preaxial foot polydactyly (HP:0001841)2.05733735
69Mitral stenosis (HP:0001718)2.04908173
70Limited hip movement (HP:0008800)2.03464205
71Exostoses (HP:0100777)2.03050597
72Hypoplastic ischia (HP:0003175)2.02871155
73Hypoplasia of the iris (HP:0007676)2.02785230
74Broad toe (HP:0001837)2.02407742
75Ulnar bowing (HP:0003031)2.00821610
76Tibial bowing (HP:0002982)2.00632054
77Midline defect of the nose (HP:0004122)1.98191911
78Bell-shaped thorax (HP:0001591)1.97894839
79Joint laxity (HP:0001388)1.97156420
80Abnormality of the labia minora (HP:0012880)1.96218791
81Short 5th finger (HP:0009237)1.93629416
82Abnormality of the right ventricle (HP:0001707)1.92233408
83Flat cornea (HP:0007720)1.91910453
84Delayed closure of the anterior fontanelle (HP:0001476)1.91853263
85Osteolytic defects of the phalanges of the hand (HP:0009771)1.91566973
86Osteolytic defects of the hand bones (HP:0009699)1.91566973
87Flared iliac wings (HP:0002869)1.91292136
88Syringomyelia (HP:0003396)1.91252954
89Spinal cord lesions (HP:0100561)1.91252954
90Breech presentation (HP:0001623)1.89592074
91Bronchomalacia (HP:0002780)1.89078036
92Abnormality of skull ossification (HP:0002703)1.88908781
93Mesangial abnormality (HP:0001966)1.88260230
94* Synostosis involving bones of the lower limbs (HP:0009138)1.88254961
95* Synostosis involving bones of the feet (HP:0009140)1.88254961
96Abnormality of the parietal bone (HP:0002696)1.87612166
97Decreased skull ossification (HP:0004331)1.87086195
98Down-sloping shoulders (HP:0200021)1.86849017
99Biconcave vertebral bodies (HP:0004586)1.86764767
100Spondylolisthesis (HP:0003302)1.85924458
101Inguinal hernia (HP:0000023)1.85418576
102Increased variability in muscle fiber diameter (HP:0003557)1.83854827
103Partial duplication of the phalanx of hand (HP:0009999)1.83386937
104Mildly elevated creatine phosphokinase (HP:0008180)1.83184289
105Nonimmune hydrops fetalis (HP:0001790)1.83070518
106Diaphragmatic weakness (HP:0009113)1.82909550
107Flexion contracture of toe (HP:0005830)1.81166261
108Joint contractures involving the joints of the feet (HP:0100492)1.81166261
109Ovoid vertebral bodies (HP:0003300)1.81026904
110Concave nail (HP:0001598)1.80950283
111Hyperextensible skin (HP:0000974)1.79691171
112Redundant skin (HP:0001582)1.78248341
113Striae distensae (HP:0001065)1.78048063
114Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77784369
115Knee flexion contracture (HP:0006380)1.77704813
116Abnormality of the ischium (HP:0003174)1.77617705
117Short nail (HP:0001799)1.77572089
118Thin ribs (HP:0000883)1.76284363
119Elbow flexion contracture (HP:0002987)1.75776100
120Delayed cranial suture closure (HP:0000270)1.75089419
121Cupped ribs (HP:0000887)1.75071993
122Hypoplastic labia majora (HP:0000059)1.74974966
123Overgrowth (HP:0001548)1.74604952
124Abnormality of the acetabulum (HP:0003170)1.72818259
125Thin bony cortex (HP:0002753)1.72170147
126Aneurysm (HP:0002617)1.72111455
127Mild short stature (HP:0003502)1.71498266
128Buphthalmos (HP:0000557)1.70513078
129Absent phalangeal crease (HP:0006109)1.69974054
130Abnormality of the radial head (HP:0003995)1.69938149
131Selective tooth agenesis (HP:0001592)1.69532741
132Hepatoblastoma (HP:0002884)1.67308776
133Narrow palate (HP:0000189)1.66100472
134Aqueductal stenosis (HP:0002410)1.65702972
135Camptodactyly of toe (HP:0001836)1.63740767
136Hip contracture (HP:0003273)1.62972210
137* Tarsal synostosis (HP:0008368)1.62592371
138Osteoarthritis (HP:0002758)1.62031675
139Broad distal phalanx of finger (HP:0009836)1.61476257
140Ectopia lentis (HP:0001083)1.61365663
141Pterygium (HP:0001059)1.60929199
142Trigonocephaly (HP:0000243)1.60476368
143Septo-optic dysplasia (HP:0100842)1.59259071
144Abnormality of the labia majora (HP:0012881)1.59017085
145Short middle phalanx of finger (HP:0005819)1.58234606
146Increased connective tissue (HP:0009025)1.58055058
147Broad hallux (HP:0010055)1.57413856
148Spinal rigidity (HP:0003306)1.57228812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB26.67058857
2KSR15.71873690
3SIK35.22576471
4BCR2.95967421
5DDR22.87815352
6PNCK2.72458429
7MAPK152.71069516
8NTRK12.54903136
9SIK12.47805605
10TTN2.34303512
11LATS12.26816456
12PDGFRA2.19554877
13ERBB22.11448744
14TRIB31.98016089
15LATS21.93559292
16AKT31.73781771
17KIT1.68359533
18PIK3CG1.63876149
19DMPK1.63523828
20MAP3K101.57117738
21TNIK1.53205954
22PAK41.49029662
23MELK1.47132284
24PRKD21.33413560
25FGFR21.33164025
26TGFBR21.31537229
27TESK11.29814091
28FGFR11.25109374
29MUSK1.24671258
30NTRK21.23356411
31ROCK21.22316165
32PAK21.21490808
33PAK31.21445770
34BRSK11.15401888
35PKN21.12001045
36MTOR1.11731809
37CDC42BPA1.11097152
38STK381.08578552
39ICK1.08202146
40CDC71.06817528
41EIF2AK31.06235751
42RIPK11.04138757
43FER1.03060646
44MINK11.01560800
45TIE10.99724881
46MARK10.97970515
47MAP3K60.97645280
48EPHB10.97278619
49PTK20.94157572
50CDK120.93960563
51CAMK1G0.92671480
52CAMK1D0.91858554
53MAPK70.91562099
54PASK0.89267513
55JAK10.88283516
56ROCK10.84843295
57DYRK1B0.83853679
58TGFBR10.81939578
59MAP3K70.81612978
60TRPM70.81278491
61BMX0.80141382
62CDK80.79037722
63PTK60.77047615
64ERBB30.75559206
65CDK180.75392195
66DYRK30.74658854
67NEK10.74502254
68BRD40.73263616
69PTK2B0.73121924
70WNK10.72812159
71STK30.72569263
72PRKCE0.71643670
73ADRBK20.71559416
74GSK3A0.68971579
75FGFR40.68534228
76EPHA30.67677286
77NEK60.66335308
78DAPK30.66254260
79STK38L0.65665559
80GRK10.65152437
81ERN10.64859484
82NLK0.64655433
83MET0.64347582
84MAP2K10.63041019
85RPS6KA20.62825607
86AKT20.62799019
87UHMK10.62455763
88RPS6KA40.62342187
89PRKCH0.62298205
90PLK20.62078250
91ABL20.61272018
92SGK20.60034365
93STK240.60021951
94MAP3K30.59091112
95CHUK0.58208912
96PINK10.57989392
97SRC0.57878524
98TTK0.57335503
99PLK30.55663297
100LRRK20.55092478
101CDK70.55052673
102FLT30.54047106
103PLK10.53985198
104CHEK20.52240981
105GRK70.50704166
106CASK0.49956957
107MKNK10.49540790
108PRKG20.47116590
109TYRO30.46553425
110CDK140.45697689
111ILK0.45161171
112CDK150.44902485
113SGK4940.44707735
114SGK2230.44707735
115FGFR30.44125727
116STK40.43437206
117TEC0.42560974
118ATR0.42145129
119LIMK10.42126867
120PRKD10.40705934
121CDK11A0.39725477
122PDGFRB0.39183903
123SGK30.38947154
124IKBKE0.38766455
125AURKB0.38750300
126PBK0.38631992
127CAMK2G0.37972471
128MAPKAPK20.37730527
129PAK60.37552806
130CAMK10.36617748
131GRK50.36052468
132ERBB40.35855301
133AURKA0.34342086
134BUB10.34309952
135MYLK0.33803624
136NEK90.33622367
137ADRBK10.32915929
138MARK20.32135346
139CHEK10.31741368
140INSR0.31599605
141MAPKAPK30.31531770
142TYK20.31319689
143FYN0.31056793
144PIK3CA0.30208464
145EEF2K0.29074903
146CSNK1A1L0.28277349
147WEE10.28020611
148CDK10.25742258
149MOS0.25525748
150MAP3K80.24952395
151MAPK90.24754405
152BRSK20.24709149
153AKT10.24660523
154CDK60.24637838
155CSNK1E0.24498557

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.77224433
2Hedgehog signaling pathway_Homo sapiens_hsa043403.63867318
3Hippo signaling pathway_Homo sapiens_hsa043903.37748499
4ECM-receptor interaction_Homo sapiens_hsa045123.12282282
5Notch signaling pathway_Homo sapiens_hsa043303.07576519
6TGF-beta signaling pathway_Homo sapiens_hsa043502.46629253
7Axon guidance_Homo sapiens_hsa043602.44557007
8Adherens junction_Homo sapiens_hsa045202.28620336
9Focal adhesion_Homo sapiens_hsa045102.28099033
10Proteoglycans in cancer_Homo sapiens_hsa052052.26133926
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.24435807
12Wnt signaling pathway_Homo sapiens_hsa043102.22352967
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.21662242
14MicroRNAs in cancer_Homo sapiens_hsa052062.19381874
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16827237
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.94381623
17Melanogenesis_Homo sapiens_hsa049161.91382854
18Bladder cancer_Homo sapiens_hsa052191.80670599
19Cell cycle_Homo sapiens_hsa041101.79607027
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75350880
21Dilated cardiomyopathy_Homo sapiens_hsa054141.74578962
22Chronic myeloid leukemia_Homo sapiens_hsa052201.66145541
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64070184
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56218659
25Small cell lung cancer_Homo sapiens_hsa052221.55991423
26Protein digestion and absorption_Homo sapiens_hsa049741.54517010
27Pathways in cancer_Homo sapiens_hsa052001.46798095
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41923280
29Viral myocarditis_Homo sapiens_hsa054161.37654328
30HTLV-I infection_Homo sapiens_hsa051661.34876293
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.29015441
32Amoebiasis_Homo sapiens_hsa051461.28877376
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27600050
34Colorectal cancer_Homo sapiens_hsa052101.27598530
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.25521842
36Melanoma_Homo sapiens_hsa052181.24202229
37Glioma_Homo sapiens_hsa052141.12716869
38Tight junction_Homo sapiens_hsa045301.11159376
39Spliceosome_Homo sapiens_hsa030401.00882737
40Pancreatic cancer_Homo sapiens_hsa052121.00367612
41Prostate cancer_Homo sapiens_hsa052150.99559463
42Complement and coagulation cascades_Homo sapiens_hsa046100.98736702
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.97298946
44Renal cell carcinoma_Homo sapiens_hsa052110.93701108
45Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93515498
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93325754
47Dorso-ventral axis formation_Homo sapiens_hsa043200.90010051
48Endometrial cancer_Homo sapiens_hsa052130.89226644
49p53 signaling pathway_Homo sapiens_hsa041150.88292881
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86583430
51Lysine degradation_Homo sapiens_hsa003100.84909905
52Oocyte meiosis_Homo sapiens_hsa041140.84481299
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84151634
54Rap1 signaling pathway_Homo sapiens_hsa040150.83331579
55Gap junction_Homo sapiens_hsa045400.83234473
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81701366
57N-Glycan biosynthesis_Homo sapiens_hsa005100.81599022
58DNA replication_Homo sapiens_hsa030300.78416226
59Estrogen signaling pathway_Homo sapiens_hsa049150.74067243
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73339067
61mRNA surveillance pathway_Homo sapiens_hsa030150.70845796
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70601964
63ErbB signaling pathway_Homo sapiens_hsa040120.69907450
64cAMP signaling pathway_Homo sapiens_hsa040240.69891967
65mTOR signaling pathway_Homo sapiens_hsa041500.69836547
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.67075196
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65372608
68RNA transport_Homo sapiens_hsa030130.64309425
69Platelet activation_Homo sapiens_hsa046110.61954376
70Calcium signaling pathway_Homo sapiens_hsa040200.61788344
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60963100
72Base excision repair_Homo sapiens_hsa034100.57422640
73Viral carcinogenesis_Homo sapiens_hsa052030.56978534
74Prion diseases_Homo sapiens_hsa050200.56116844
75Pertussis_Homo sapiens_hsa051330.55900896
76Malaria_Homo sapiens_hsa051440.55572342
77Hepatitis B_Homo sapiens_hsa051610.54042110
78HIF-1 signaling pathway_Homo sapiens_hsa040660.52265173
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52113145
80Renin secretion_Homo sapiens_hsa049240.52089792
81Non-small cell lung cancer_Homo sapiens_hsa052230.51423867
82Oxytocin signaling pathway_Homo sapiens_hsa049210.50280055
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48018180
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.47628815
85Insulin secretion_Homo sapiens_hsa049110.47583486
86Taste transduction_Homo sapiens_hsa047420.46515868
87AMPK signaling pathway_Homo sapiens_hsa041520.45245226
88Phagosome_Homo sapiens_hsa041450.44419201
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.44223646
90Cholinergic synapse_Homo sapiens_hsa047250.43912922
91Renin-angiotensin system_Homo sapiens_hsa046140.43742293
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43685230
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43399585
94Shigellosis_Homo sapiens_hsa051310.43093892
95Ras signaling pathway_Homo sapiens_hsa040140.42549121
96Salivary secretion_Homo sapiens_hsa049700.42175639
97Thyroid hormone synthesis_Homo sapiens_hsa049180.42084156
98TNF signaling pathway_Homo sapiens_hsa046680.41963054
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.41927436
100Dopaminergic synapse_Homo sapiens_hsa047280.41865087
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41263746
102Thyroid cancer_Homo sapiens_hsa052160.40834192
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40310176
104Toxoplasmosis_Homo sapiens_hsa051450.39081642
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38632736
106Insulin signaling pathway_Homo sapiens_hsa049100.37256455
107One carbon pool by folate_Homo sapiens_hsa006700.36386935
108Prolactin signaling pathway_Homo sapiens_hsa049170.36099378
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35800217
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35333441
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34824486
112Protein export_Homo sapiens_hsa030600.34570670
113Amphetamine addiction_Homo sapiens_hsa050310.32405349
114Alcoholism_Homo sapiens_hsa050340.31863313
115Endocytosis_Homo sapiens_hsa041440.31741588
116Cocaine addiction_Homo sapiens_hsa050300.30323708
117Mineral absorption_Homo sapiens_hsa049780.30304397
118Lysosome_Homo sapiens_hsa041420.29970677
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29251538
120MAPK signaling pathway_Homo sapiens_hsa040100.29226833
121Glutamatergic synapse_Homo sapiens_hsa047240.29198295
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.28628148
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28194406
124FoxO signaling pathway_Homo sapiens_hsa040680.26548569
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.25928108
126Glucagon signaling pathway_Homo sapiens_hsa049220.25142746
127Choline metabolism in cancer_Homo sapiens_hsa052310.25039897
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24716656
129Epstein-Barr virus infection_Homo sapiens_hsa051690.24541029
130Systemic lupus erythematosus_Homo sapiens_hsa053220.21204216
131GnRH signaling pathway_Homo sapiens_hsa049120.21097235

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