SULF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.09621106
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.83272307
3protein heterotrimerization (GO:0070208)4.35205922
4ear development (GO:0043583)4.33648058
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.18196592
6paraxial mesoderm development (GO:0048339)4.16922774
7dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.06997427
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.00270765
9desmosome organization (GO:0002934)3.99986101
10neuron projection extension involved in neuron projection guidance (GO:1902284)3.93444819
11axon extension involved in axon guidance (GO:0048846)3.93444819
12positive regulation of keratinocyte differentiation (GO:0045618)3.90058759
13epithelial cell differentiation involved in prostate gland development (GO:0060742)3.81916557
14bone trabecula formation (GO:0060346)3.80024824
15positive regulation of Cdc42 GTPase activity (GO:0043089)3.78425089
16hippo signaling (GO:0035329)3.77464642
17polarized epithelial cell differentiation (GO:0030859)3.76303620
18lateral sprouting from an epithelium (GO:0060601)3.66226576
19chondrocyte proliferation (GO:0035988)3.53232459
20negative regulation of catenin import into nucleus (GO:0035414)3.47549756
21collagen fibril organization (GO:0030199)3.43840497
22negative regulation of chondrocyte differentiation (GO:0032331)3.38562085
23cell proliferation involved in metanephros development (GO:0072203)3.34971106
24cell-substrate junction assembly (GO:0007044)3.34395913
25gonadal mesoderm development (GO:0007506)3.29230397
26embryonic eye morphogenesis (GO:0048048)3.26936962
27vagina development (GO:0060068)3.26500425
28branching involved in mammary gland duct morphogenesis (GO:0060444)3.25656972
29establishment of apical/basal cell polarity (GO:0035089)3.24978510
30craniofacial suture morphogenesis (GO:0097094)3.18492073
31hepatocyte apoptotic process (GO:0097284)3.17598284
32embryonic camera-type eye morphogenesis (GO:0048596)3.16729707
33peptidyl-tyrosine autophosphorylation (GO:0038083)3.16048968
34negative regulation of cartilage development (GO:0061037)3.12028474
35maternal placenta development (GO:0001893)3.11092729
36basement membrane organization (GO:0071711)3.08379884
37amyloid precursor protein catabolic process (GO:0042987)3.08218447
38Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.06393839
39outer ear morphogenesis (GO:0042473)3.05147660
40regulation of fatty acid beta-oxidation (GO:0031998)3.04669594
41dermatan sulfate biosynthetic process (GO:0030208)3.01572315
42positive regulation of epidermal cell differentiation (GO:0045606)3.00865883
43regulation of establishment of planar polarity (GO:0090175)3.00343455
44negative regulation of axon extension involved in axon guidance (GO:0048843)2.99605045
45establishment of nucleus localization (GO:0040023)2.99063766
46convergent extension (GO:0060026)2.98402002
47camera-type eye morphogenesis (GO:0048593)2.96341876
48cochlea morphogenesis (GO:0090103)2.93809202
49skeletal muscle adaptation (GO:0043501)2.92509891
50sequestering of extracellular ligand from receptor (GO:0035581)2.86486342
51non-canonical Wnt signaling pathway (GO:0035567)2.86221468
52establishment or maintenance of monopolar cell polarity (GO:0061339)2.86064928
53establishment of monopolar cell polarity (GO:0061162)2.86064928
54regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.85984701
55regulation of catenin import into nucleus (GO:0035412)2.84177444
56insulin-like growth factor receptor signaling pathway (GO:0048009)2.84177378
57negative regulation of axon guidance (GO:1902668)2.83722277
58adherens junction assembly (GO:0034333)2.83613255
59focal adhesion assembly (GO:0048041)2.80490865
60cell-substrate adherens junction assembly (GO:0007045)2.80490865
61endothelial cell chemotaxis (GO:0035767)2.80332439
62anterior/posterior axis specification, embryo (GO:0008595)2.79684874
63G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.79562394
64striated muscle atrophy (GO:0014891)2.77047918
65positive regulation of receptor recycling (GO:0001921)2.76234133
66anatomical structure regression (GO:0060033)2.74416146
67regulation of cell proliferation involved in kidney development (GO:1901722)2.74294295
68endodermal cell differentiation (GO:0035987)2.73657991
69negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.73222013
70regulation of water loss via skin (GO:0033561)2.72145118
71dermatan sulfate metabolic process (GO:0030205)2.71787083
72vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71696725
73regulation of axon extension involved in axon guidance (GO:0048841)2.71350954
74endocardial cushion development (GO:0003197)2.70174411
75positive regulation of SMAD protein import into nucleus (GO:0060391)2.70022510
76regulation of SMAD protein import into nucleus (GO:0060390)2.69862765
77embryonic retina morphogenesis in camera-type eye (GO:0060059)2.68380277
78gastrulation with mouth forming second (GO:0001702)2.66609527
79protein localization to endosome (GO:0036010)2.66580907
80notochord development (GO:0030903)2.66313002
81cytoskeletal anchoring at plasma membrane (GO:0007016)2.64966634
82regulation of axon guidance (GO:1902667)2.64397879
83cardiac myofibril assembly (GO:0055003)2.64074558
84positive regulation of fatty acid beta-oxidation (GO:0032000)2.63947797
85collagen metabolic process (GO:0032963)2.63483798
86regulation of endothelial cell chemotaxis (GO:2001026)2.63320575
87body morphogenesis (GO:0010171)2.62062516
88mesenchymal cell proliferation (GO:0010463)2.62001337
89apoptotic cell clearance (GO:0043277)2.61608303
90* chondrocyte development (GO:0002063)2.61473466
91vascular endothelial growth factor signaling pathway (GO:0038084)2.61104729
92apical protein localization (GO:0045176)2.60657470
93mesenchyme development (GO:0060485)2.60404158
94lung-associated mesenchyme development (GO:0060484)2.60001977
95endocardial cushion morphogenesis (GO:0003203)2.59156456
96positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.58312975
97embryonic cranial skeleton morphogenesis (GO:0048701)2.58225036
98activation of Rac GTPase activity (GO:0032863)2.57553705
99hindlimb morphogenesis (GO:0035137)2.57160543
100collagen catabolic process (GO:0030574)2.56133919
101heart morphogenesis (GO:0003007)2.55849605
102head development (GO:0060322)2.55313541
103surfactant homeostasis (GO:0043129)2.55002663
104multicellular organismal macromolecule metabolic process (GO:0044259)2.54971081
105collecting duct development (GO:0072044)2.54560771
106mesenchyme morphogenesis (GO:0072132)2.54059522
107regulation of glucose import in response to insulin stimulus (GO:2001273)2.53343113
108modulation by virus of host morphology or physiology (GO:0019048)2.52650398
109regulation of cartilage development (GO:0061035)2.51902181
110myelination in peripheral nervous system (GO:0022011)2.51788069
111peripheral nervous system axon ensheathment (GO:0032292)2.51788069
112negative regulation of embryonic development (GO:0045992)2.50877564
113branching involved in salivary gland morphogenesis (GO:0060445)2.49887223
114epithelial cell-cell adhesion (GO:0090136)2.49785395
115wound healing, spreading of cells (GO:0044319)2.48943454
116cell surface receptor signaling pathway involved in heart development (GO:0061311)2.48315480
117regulation of transforming growth factor beta2 production (GO:0032909)2.47986272
118positive regulation of catenin import into nucleus (GO:0035413)2.47830129
119cardiac muscle cell proliferation (GO:0060038)2.47452758
120positive regulation of mesenchymal cell proliferation (GO:0002053)2.47131248
121eye morphogenesis (GO:0048592)2.47042048
122negative chemotaxis (GO:0050919)2.46724169
123regulation of hippo signaling (GO:0035330)2.45816972
124regulation of extracellular matrix disassembly (GO:0010715)2.45336243
125intestinal epithelial cell development (GO:0060576)2.44896526
126response to water (GO:0009415)2.44891628
127mesonephros development (GO:0001823)2.44668036
128embryonic hindlimb morphogenesis (GO:0035116)2.43720932
129proximal/distal pattern formation (GO:0009954)2.42318600
130regulation of chondrocyte differentiation (GO:0032330)2.42136659
131establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.41931135
132regulation of mesenchymal cell proliferation (GO:0010464)2.41890346
133regulation of Cdc42 GTPase activity (GO:0043088)2.41481335
134positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41322707
135semaphorin-plexin signaling pathway (GO:0071526)2.39798564
136metanephric mesenchyme development (GO:0072075)2.39635322
137establishment of planar polarity (GO:0001736)2.39192741
138establishment of tissue polarity (GO:0007164)2.39192741
139multicellular organismal metabolic process (GO:0044236)2.38425693
140glucose 6-phosphate metabolic process (GO:0051156)2.38144866
141amyloid precursor protein metabolic process (GO:0042982)2.38031005
142cranial suture morphogenesis (GO:0060363)2.37696207
143COPI coating of Golgi vesicle (GO:0048205)2.37664376
144Golgi transport vesicle coating (GO:0048200)2.37664376
145mannose metabolic process (GO:0006013)2.37328017
146mesenchymal-epithelial cell signaling (GO:0060638)2.37206402
147multicellular organismal catabolic process (GO:0044243)2.36501638
148negative regulation of cell size (GO:0045792)2.36237537
149glial cell migration (GO:0008347)2.35841267
150bone morphogenesis (GO:0060349)2.35587992
151kidney mesenchyme development (GO:0072074)2.35481636
152embryonic skeletal joint morphogenesis (GO:0060272)2.35383828
153stress fiber assembly (GO:0043149)2.34934449
154regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.34744909
155negative regulation of fatty acid transport (GO:2000192)2.34320247
156female genitalia development (GO:0030540)2.34157580
157cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.33548598
158epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.32533541
159mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.32116116
160plasma membrane repair (GO:0001778)2.31733453
161apoptotic process involved in morphogenesis (GO:0060561)2.31535041
162cell proliferation involved in kidney development (GO:0072111)2.30334326
163cardiac right ventricle morphogenesis (GO:0003215)2.30046057
164bundle of His cell to Purkinje myocyte communication (GO:0086069)2.28801424
165positive regulation of epidermis development (GO:0045684)2.27797048
166negative regulation of glial cell proliferation (GO:0060253)2.27385569
167regulation of establishment or maintenance of cell polarity (GO:0032878)2.25078703
168negative regulation of Ras GTPase activity (GO:0034261)2.22745355
169modulation by symbiont of host defense response (GO:0052031)2.22390604
170modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22390604
171modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.22390604
172positive regulation by organism of defense response of other organism involved in symbiotic interact2.22390604
173modulation by symbiont of host immune response (GO:0052553)2.22390604
174positive regulation by symbiont of host defense response (GO:0052509)2.22390604
175skin morphogenesis (GO:0043589)2.21906355
176intracellular estrogen receptor signaling pathway (GO:0030520)2.21839944
177cell adhesion mediated by integrin (GO:0033627)2.20592850
178interferon-gamma secretion (GO:0072643)2.20216766
179face development (GO:0060324)2.19330445
180negative regulation of cell junction assembly (GO:1901889)2.17876688
181negative regulation of adherens junction organization (GO:1903392)2.17876688

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.81821382
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.43577224
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.19244364
4* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.54523675
5* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.51145316
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38450057
7RACK7_27058665_Chip-Seq_MCF-7_Human2.36602482
8* RUNX1_27514584_Chip-Seq_MCF-7_Human2.26157866
9* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.25478254
10* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.23696127
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16908231
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16908231
13* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11738531
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.02228477
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.02228477
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.02228477
17* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.01289422
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97503409
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97415715
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.95866763
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.93492683
22ZNF263_19887448_ChIP-Seq_K562_Human1.93370647
23* TP53_20018659_ChIP-ChIP_R1E_Mouse1.92955847
24LXR_22292898_ChIP-Seq_THP-1_Human1.91693508
25* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90880710
26* ELK3_25401928_ChIP-Seq_HUVEC_Human1.90204699
27CLOCK_20551151_ChIP-Seq_293T_Human1.85198092
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84648354
29* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78124834
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77844417
31* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.77532300
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77331066
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76997061
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74834727
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74502902
36TCF7_22412390_ChIP-Seq_EML_Mouse1.73521520
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.67875614
38* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.67568076
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66491861
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66224072
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64787368
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64274957
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.64205596
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62732371
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61787858
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.60594566
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59864054
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58639629
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58312815
50* RING1B_27294783_Chip-Seq_NPCs_Mouse1.56743737
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55740466
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53002314
53* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52552163
54* EP300_21415370_ChIP-Seq_HL-1_Mouse1.52002447
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51575094
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50735252
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.48623640
58KDM2B_26808549_Chip-Seq_K562_Human1.48540002
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46863976
60VDR_21846776_ChIP-Seq_THP-1_Human1.43815942
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43647746
62DROSHA_22980978_ChIP-Seq_HELA_Human1.43354133
63* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42632599
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42212387
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.41503809
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.40723296
67* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.39417448
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.38928039
69* AR_21572438_ChIP-Seq_LNCaP_Human1.37999669
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36987822
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36262496
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30734646
73* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30014602
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29736339
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.29132899
76EZH2_22144423_ChIP-Seq_EOC_Human1.28462506
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.27298342
78* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27157900
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25778064
80* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23948759
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23433942
82* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23336126
83* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22039938
84* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19523326
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19046810
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18936414
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18446614
88* GATA3_24758297_ChIP-Seq_MCF-7_Human1.16366502
89* CJUN_26792858_Chip-Seq_BT549_Human1.15433731
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.12947118
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12749674
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.11916050
93* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11824203
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10838200
95* AHR_22903824_ChIP-Seq_MCF-7_Human1.10199576
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09787111
97KDM2B_26808549_Chip-Seq_DND41_Human1.09753091
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09642220
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08669985
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08518618
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08058466
102KLF5_25053715_ChIP-Seq_YYC3_Human1.08024989
103* SMC4_20622854_ChIP-Seq_HELA_Human1.08019461
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07723498
105* TP53_23651856_ChIP-Seq_MEFs_Mouse1.07685146
106VDR_24763502_ChIP-Seq_THP-1_Human1.07606738
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07453791
108MYC_22102868_ChIP-Seq_BL_Human1.07066376
109* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06970441
110* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06965203
111SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06829546
112TP53_16413492_ChIP-PET_HCT116_Human1.06500790
113* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05682778
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05199048
115* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04004277
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02740536
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.02018139
118* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01269473
119EGR1_19374776_ChIP-ChIP_THP-1_Human1.00205352
120BRD4_25478319_ChIP-Seq_HGPS_Human0.99919655
121* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98790045
122* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98790045
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.98608626
124* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98373900
125* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98236509
126* UBF1/2_26484160_Chip-Seq_HMECs_Human0.97995128
127* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97895915
128* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97873335
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97618504
130* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97244195
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.96236252
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.96236252
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96144361
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95685311
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95298998
136* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95157252
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95030910
138STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94451070
139* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93464230
140CREB1_26743006_Chip-Seq_LNCaP_Human0.93416518
141* ARNT_22903824_ChIP-Seq_MCF-7_Human0.93404265
142* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93248413
143AR_19668381_ChIP-Seq_PC3_Human0.93124819
144ATF3_27146783_Chip-Seq_COLON_Human0.92420654
145* RXR_22158963_ChIP-Seq_LIVER_Mouse0.89964268
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.89316800
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88580619
148TP53_22127205_ChIP-Seq_IMR90_Human0.88401135
149TP63_22573176_ChIP-Seq_HFKS_Human0.87712750
150SA1_27219007_Chip-Seq_ERYTHROID_Human0.87368078
151CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85914951
152* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85521337
153SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85124932
154PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84896016
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83789735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.04730995
2MP0000579_abnormal_nail_morphology3.98152018
3MP0005275_abnormal_skin_tensile3.25874590
4MP0005623_abnormal_meninges_morphology3.25039080
5MP0005503_abnormal_tendon_morphology3.22362317
6MP0005409_darkened_coat_color3.20090045
7MP0003705_abnormal_hypodermis_morpholog3.00256489
8MP0004381_abnormal_hair_follicle2.76186475
9MP0004272_abnormal_basement_membrane2.63246925
10MP0002796_impaired_skin_barrier2.62349399
11MP0004264_abnormal_extraembryonic_tissu2.61506363
12MP0003385_abnormal_body_wall2.56855848
13MP0010030_abnormal_orbit_morphology2.55330431
14MP0010234_abnormal_vibrissa_follicle2.48458275
15MP0009053_abnormal_anal_canal2.38336368
16MP0008260_abnormal_autophagy2.30351994
17MP0000383_abnormal_hair_follicle2.25429403
18MP0000537_abnormal_urethra_morphology2.18253492
19MP0002098_abnormal_vibrissa_morphology2.12278025
20MP0010678_abnormal_skin_adnexa2.07521431
21MP0005058_abnormal_lysosome_morphology2.05475572
22MP0009250_abnormal_appendicular_skeleto2.00656749
23MP0000534_abnormal_ureter_morphology1.95477834
24MP0000566_synostosis1.93536938
25MP0002282_abnormal_trachea_morphology1.92329566
26MP0001958_emphysema1.91383942
27MP0003191_abnormal_cellular_cholesterol1.90800536
28MP0003122_maternal_imprinting1.90791720
29MP0003453_abnormal_keratinocyte_physiol1.88404824
30MP0003941_abnormal_skin_development1.85892074
31MP0005451_abnormal_body_composition1.81691769
32MP0005076_abnormal_cell_differentiation1.79236932
33MP0002249_abnormal_larynx_morphology1.79190897
34MP0003283_abnormal_digestive_organ1.79074911
35MP0000733_abnormal_muscle_development1.79036713
36MP0003942_abnormal_urinary_system1.78727982
37MP0005508_abnormal_skeleton_morphology1.77542607
38MP0003878_abnormal_ear_physiology1.73296643
39MP0005377_hearing/vestibular/ear_phenot1.73296643
40MP0000428_abnormal_craniofacial_morphol1.72189877
41MP0004858_abnormal_nervous_system1.71300000
42MP0005248_abnormal_Harderian_gland1.67161144
43MP0004233_abnormal_muscle_weight1.65767143
44MP0002108_abnormal_muscle_morphology1.62149115
45MP0003279_aneurysm1.61713477
46MP0003937_abnormal_limbs/digits/tail_de1.59027026
47MP0003329_amyloid_beta_deposits1.56043237
48MP0003755_abnormal_palate_morphology1.53887278
49MP0000377_abnormal_hair_follicle1.51440164
50MP0002653_abnormal_ependyma_morphology1.51391883
51MP0000049_abnormal_middle_ear1.50727811
52MP0005501_abnormal_skin_physiology1.50619475
53* MP0003115_abnormal_respiratory_system1.43433005
54MP0004782_abnormal_surfactant_physiolog1.42605665
55MP0003935_abnormal_craniofacial_develop1.39914730
56MP0009384_cardiac_valve_regurgitation1.37848214
57* MP0002932_abnormal_joint_morphology1.37702998
58MP0005367_renal/urinary_system_phenotyp1.36916073
59MP0000516_abnormal_urinary_system1.36916073
60MP0005257_abnormal_intraocular_pressure1.36144427
61MP0003183_abnormal_peptide_metabolism1.32418732
62MP0004134_abnormal_chest_morphology1.31526527
63MP0000762_abnormal_tongue_morphology1.30517622
64MP0003119_abnormal_digestive_system1.30492311
65MP0002116_abnormal_craniofacial_bone1.29255786
66MP0003566_abnormal_cell_adhesion1.27468225
67MP0001216_abnormal_epidermal_layer1.27285972
68MP0001299_abnormal_eye_distance/1.26835625
69MP0004084_abnormal_cardiac_muscle1.22874527
70MP0003172_abnormal_lysosome_physiology1.21150364
71MP0003091_abnormal_cell_migration1.21139342
72MP0003123_paternal_imprinting1.20355082
73MP0000432_abnormal_head_morphology1.20242508
74MP0001849_ear_inflammation1.19830259
75MP0000538_abnormal_urinary_bladder1.19345520
76MP0000778_abnormal_nervous_system1.19236665
77MP0003950_abnormal_plasma_membrane1.18730983
78MP0000751_myopathy1.17058263
79MP0002233_abnormal_nose_morphology1.16598804
80MP0004185_abnormal_adipocyte_glucose1.15443696
81MP0003828_pulmonary_edema1.14761901
82MP0000163_abnormal_cartilage_morphology1.14200075
83MP0003300_gastrointestinal_ulcer1.13720339
84MP0000627_abnormal_mammary_gland1.11566588
85MP0004133_heterotaxia1.11384875
86MP0002896_abnormal_bone_mineralization1.10556752
87MP0002697_abnormal_eye_size1.08904616
88MP0010771_integument_phenotype1.07180501
89MP0002111_abnormal_tail_morphology1.06578728
90MP0003567_abnormal_fetal_cardiomyocyte1.02536157
91MP0004197_abnormal_fetal_growth/weight/1.02478036
92MP0000427_abnormal_hair_cycle1.01789166
93MP0009840_abnormal_foam_cell1.01102427
94MP0005171_absent_coat_pigmentation1.01032865
95MP0002084_abnormal_developmental_patter1.00165230
96MP0005666_abnormal_adipose_tissue0.99393519
97MP0001293_anophthalmia0.98672223
98MP0002115_abnormal_skeleton_extremities0.98657133
99MP0000462_abnormal_digestive_system0.97522712
100MP0002109_abnormal_limb_morphology0.97209216
101MP0006138_congestive_heart_failure0.96821516
102MP0005375_adipose_tissue_phenotype0.96530925
103MP0003861_abnormal_nervous_system0.96216475
104MP0003121_genomic_imprinting0.96111461
105MP0000470_abnormal_stomach_morphology0.94465993
106MP0009931_abnormal_skin_appearance0.93237834
107MP0004947_skin_inflammation0.93200261
108MP0002085_abnormal_embryonic_tissue0.92491369
109* MP0002114_abnormal_axial_skeleton0.92487025
110MP0002089_abnormal_postnatal_growth/wei0.92387596
111MP0005390_skeleton_phenotype0.89221594
112MP0002925_abnormal_cardiovascular_devel0.88186599
113MP0010352_gastrointestinal_tract_polyps0.88089791
114MP0004087_abnormal_muscle_fiber0.87223600
115MP0000678_abnormal_parathyroid_gland0.87138566
116MP0001533_abnormal_skeleton_physiology0.85988472
117MP0000767_abnormal_smooth_muscle0.85432535
118MP0009780_abnormal_chondrocyte_physiolo0.85344732
119MP0003938_abnormal_ear_development0.84466862
120MP0002092_abnormal_eye_morphology0.83759488
121MP0002877_abnormal_melanocyte_morpholog0.83452519
122MP0005023_abnormal_wound_healing0.83063066
123MP0005670_abnormal_white_adipose0.82310451
124MP0002909_abnormal_adrenal_gland0.82255748
125MP0000003_abnormal_adipose_tissue0.81923840
126MP0002113_abnormal_skeleton_development0.80690067
127MP0010630_abnormal_cardiac_muscle0.80481153
128MP0002060_abnormal_skin_morphology0.80448087
129MP0003436_decreased_susceptibility_to0.80300420
130MP0003634_abnormal_glial_cell0.80080266
131MP0001340_abnormal_eyelid_morphology0.79493987
132MP0004885_abnormal_endolymph0.78394322
133MP0002295_abnormal_pulmonary_circulatio0.77977073
134MP0000858_altered_metastatic_potential0.77547261
135MP0010368_abnormal_lymphatic_system0.77520511
136MP0004883_abnormal_blood_vessel0.76036105
137* MP0000467_abnormal_esophagus_morphology0.75896003
138MP0002938_white_spotting0.75382184
139MP0001286_abnormal_eye_development0.75089644
140MP0001348_abnormal_lacrimal_gland0.74703190
141MP0003303_peritoneal_inflammation0.73741735
142MP0002998_abnormal_bone_remodeling0.73366862
143MP0003866_abnormal_defecation0.73012084
144MP0006054_spinal_hemorrhage0.72985965
145MP0004145_abnormal_muscle_electrophysio0.72098108
146MP0000569_abnormal_digit_pigmentation0.71668021
147MP0003137_abnormal_impulse_conducting0.71542659
148MP0001614_abnormal_blood_vessel0.71176712
149MP0003638_abnormal_response/metabolism_0.65636320
150MP0003724_increased_susceptibility_to0.63906665
151MP0001727_abnormal_embryo_implantation0.63075042
152MP0003936_abnormal_reproductive_system0.61350266
153MP0001851_eye_inflammation0.59661674

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.92870405
2Shallow orbits (HP:0000586)4.70373292
3Premature rupture of membranes (HP:0001788)4.65922738
4J-shaped sella turcica (HP:0002680)4.29760704
5Absent frontal sinuses (HP:0002688)3.78774761
6Broad metatarsal (HP:0001783)3.61470399
7Ankle contracture (HP:0006466)3.52341127
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.41894587
9Short 4th metacarpal (HP:0010044)3.41894587
10Broad face (HP:0000283)3.38342816
11Abnormality of the 4th metacarpal (HP:0010012)3.37127998
12Milia (HP:0001056)3.31189405
13Deformed sella turcica (HP:0002681)3.15090955
14Cerebral aneurysm (HP:0004944)3.08141304
15Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.06218936
16Bladder diverticulum (HP:0000015)3.04478586
17Coronal craniosynostosis (HP:0004440)3.03194394
18Esophageal varix (HP:0002040)2.96462217
19Aortic dissection (HP:0002647)2.89908915
20Micronodular cirrhosis (HP:0001413)2.77749760
21Fragile nails (HP:0001808)2.76117745
22Renal duplication (HP:0000075)2.73327167
23Deep venous thrombosis (HP:0002625)2.69616784
24Flat acetabular roof (HP:0003180)2.67117678
25Thin bony cortex (HP:0002753)2.64804208
26Abnormality of nail color (HP:0100643)2.57486554
27Right ventricular cardiomyopathy (HP:0011663)2.57296835
28Soft skin (HP:0000977)2.52931275
29Atrophic scars (HP:0001075)2.52894123
30Wide anterior fontanel (HP:0000260)2.51815436
31Genu recurvatum (HP:0002816)2.50628031
32Abnormality of the frontal sinuses (HP:0002687)2.50549713
33Mitral valve prolapse (HP:0001634)2.49547264
34Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.48865657
35Microglossia (HP:0000171)2.44002715
36Buphthalmos (HP:0000557)2.40221097
37Blue sclerae (HP:0000592)2.36847856
38Pterygium (HP:0001059)2.35655559
39Deviation of the hallux (HP:0010051)2.34789109
40Germ cell neoplasia (HP:0100728)2.34313864
41Distal lower limb muscle weakness (HP:0009053)2.34165094
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.30203601
43Abnormality of dentin (HP:0010299)2.29771049
44Abnormality of the sella turcica (HP:0002679)2.29179556
45Ridged nail (HP:0001807)2.28504740
46Aplasia cutis congenita (HP:0001057)2.27532969
47Turricephaly (HP:0000262)2.27365640
48Aortic aneurysm (HP:0004942)2.26727059
49Fragile skin (HP:0001030)2.25352689
50Neurofibrillary tangles (HP:0002185)2.23038043
51Septate vagina (HP:0001153)2.16788130
52Plantar hyperkeratosis (HP:0007556)2.16416638
53Hallux valgus (HP:0001822)2.16310304
54Alopecia of scalp (HP:0002293)2.14805192
55Follicular hyperkeratosis (HP:0007502)2.13974596
56Neonatal short-limb short stature (HP:0008921)2.13733541
57Hyperextensible skin (HP:0000974)2.11776278
58Macroorchidism (HP:0000053)2.11005126
59Hypoplasia of dental enamel (HP:0006297)2.10881602
60Thick nail (HP:0001805)2.10347526
61Onycholysis (HP:0001806)2.09700172
62Broad thumb (HP:0011304)2.09080799
63Hepatoblastoma (HP:0002884)2.08427529
64Wrist flexion contracture (HP:0001239)2.08283071
65Cerebral inclusion bodies (HP:0100314)2.08007840
66Syringomyelia (HP:0003396)2.06908840
67Spinal cord lesions (HP:0100561)2.06908840
68Vertebral hypoplasia (HP:0008417)2.06796428
69Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.06796428
70Bronchomalacia (HP:0002780)2.06613984
71Abdominal distention (HP:0003270)2.06532035
72Spinal rigidity (HP:0003306)2.06302876
73Dilatation of the ascending aorta (HP:0005111)2.05272962
74Hyperparathyroidism (HP:0000843)2.03727917
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03552665
76Back pain (HP:0003418)2.03435549
77Peritonitis (HP:0002586)2.03092734
78Flat cornea (HP:0007720)2.02195753
79Concave nail (HP:0001598)2.01891867
80Lymphangioma (HP:0100764)2.01853003
81Vascular tortuosity (HP:0004948)2.01655239
82Wormian bones (HP:0002645)2.01616663
83Arterial tortuosity (HP:0005116)1.99490005
84Nail dystrophy (HP:0008404)1.98546700
85Broad toe (HP:0001837)1.98480333
86Increased cerebral lipofuscin (HP:0011813)1.97357733
87Type 1 muscle fiber predominance (HP:0003803)1.95300262
88Joint laxity (HP:0001388)1.94917125
89Amyloidosis (HP:0011034)1.94439010
90Broad long bones (HP:0005622)1.93339464
91Hyporeflexia of lower limbs (HP:0002600)1.93149284
92Abnormal vertebral ossification (HP:0100569)1.92357236
93Arnold-Chiari malformation (HP:0002308)1.91878032
94Increased variability in muscle fiber diameter (HP:0003557)1.90731848
95Overgrowth (HP:0001548)1.90501606
96Increased connective tissue (HP:0009025)1.89686104
97Polygenic inheritance (HP:0010982)1.89575357
98Mesomelia (HP:0003027)1.88438571
99Asymmetry of the thorax (HP:0001555)1.88353207
100Supernumerary ribs (HP:0005815)1.86554959
101Bowel diverticulosis (HP:0005222)1.86220942
102Obstructive sleep apnea (HP:0002870)1.85753622
103Hypotrichosis (HP:0001006)1.84769690
104Short hallux (HP:0010109)1.84225355
105Broad ribs (HP:0000885)1.83180583
106Abnormality of the 2nd finger (HP:0004100)1.81497902
107Inguinal hernia (HP:0000023)1.81420688
108Advanced eruption of teeth (HP:0006288)1.80935252
109Testicular neoplasm (HP:0010788)1.80894766
110Long toe (HP:0010511)1.80713463
111Spinal cord compression (HP:0002176)1.78378802
112Broad phalanx (HP:0006009)1.77766987
113Renovascular hypertension (HP:0100817)1.77691217
114Preaxial foot polydactyly (HP:0001841)1.77150943
115Mildly elevated creatine phosphokinase (HP:0008180)1.77090384
116Hypoplastic ischia (HP:0003175)1.76570324
117Cervical subluxation (HP:0003308)1.75854258
118Hemorrhage of the eye (HP:0011885)1.75316236
119Hypercortisolism (HP:0001578)1.75060441
120Disproportionate tall stature (HP:0001519)1.75057446
121Broad finger (HP:0001500)1.74979816
122Broad phalanges of the hand (HP:0009768)1.74878702
123Mucopolysacchariduria (HP:0008155)1.74568728
124Urinary glycosaminoglycan excretion (HP:0003541)1.74568728
125Glomerulonephritis (HP:0000099)1.73745838
126Short nail (HP:0001799)1.73471083
127Scapular winging (HP:0003691)1.72709276
128Hyperacusis (HP:0010780)1.72612937
129Aneurysm (HP:0002617)1.72440261
130Narrow palate (HP:0000189)1.70878701
131Aplasia/Hypoplasia of the hallux (HP:0008362)1.70010101
132Ankyloglossia (HP:0010296)1.69706963
133Subacute progressive viral hepatitis (HP:0006572)1.68249771
134Tarsal synostosis (HP:0008368)1.68063854
135Spondylolisthesis (HP:0003302)1.67929198
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.67893081
137Abnormality of incisor morphology (HP:0011063)1.67280601
138Short phalanx of the thumb (HP:0009660)1.67209875
139Bell-shaped thorax (HP:0001591)1.67134404
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.66885181
141Patellar dislocation (HP:0002999)1.66674835
142Metaphyseal cupping (HP:0003021)1.66513160
143Narrow nasal bridge (HP:0000446)1.65699199
144Hypoplasia of the iris (HP:0007676)1.64852746
145Dysostosis multiplex (HP:0000943)1.64500129
146Vertebral compression fractures (HP:0002953)1.63927382
147Mitral regurgitation (HP:0001653)1.63189540
148Craniofacial hyperostosis (HP:0004493)1.62838050
149Protruding ear (HP:0000411)1.62673523
150Abnormality of the middle phalanges of the toes (HP:0010183)1.62413936
151Morphological abnormality of the middle ear (HP:0008609)1.62296723
152Cutaneous finger syndactyly (HP:0010554)1.62101701
153Overriding aorta (HP:0002623)1.61972855
154Selective tooth agenesis (HP:0001592)1.60643877
155Broad hallux (HP:0010055)1.60512881
156Abnormality of oral frenula (HP:0000190)1.60441083
157Abnormality of macrophages (HP:0004311)1.60146751
158Amelogenesis imperfecta (HP:0000705)1.59154007
159Abnormality of mucopolysaccharide metabolism (HP:0011020)1.58354300
160Abnormality of polysaccharide metabolism (HP:0011012)1.58354300
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.58354300
162Short 1st metacarpal (HP:0010034)1.58342661
163Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.58342661
164Exostoses (HP:0100777)1.57859928
165Astrocytoma (HP:0009592)1.57682888
166Abnormality of the astrocytes (HP:0100707)1.57682888
167Ulnar bowing (HP:0003031)1.57657999
168Supernumerary bones of the axial skeleton (HP:0009144)1.57512184
169Trigonocephaly (HP:0000243)1.57244227
170Esophageal atresia (HP:0002032)1.56844014
171Abnormality of the radial head (HP:0003995)1.56152008
172Synostosis involving bones of the lower limbs (HP:0009138)1.55771155
173Synostosis involving bones of the feet (HP:0009140)1.55771155
174Congenital glaucoma (HP:0001087)1.55626159
175Anophthalmia (HP:0000528)1.55105766
176Short humerus (HP:0005792)1.54167082
177Enlarged penis (HP:0000040)1.53348003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR23.73056429
2PDGFRA3.24044358
3TRIB33.04604739
4LATS12.88629354
5TYRO32.74045831
6LATS22.66477759
7ICK2.58046614
8EPHB22.55079060
9SMG12.36206481
10RIPK12.18164057
11SIK12.16725598
12TTN2.11089926
13CDK122.09604760
14FGFR42.04869532
15PKN22.03017244
16DMPK1.97573280
17SCYL21.93578544
18CAMK1D1.90049070
19CAMK1G1.88220504
20BMX1.80684299
21NEK61.77973591
22RPS6KB21.77521866
23PAK61.69190029
24MAPKAPK31.62756314
25FER1.61921517
26MAP2K21.55157418
27MAP3K21.41264259
28PAK31.38491582
29PAK21.37177959
30IRAK31.37101630
31CSF1R1.36979766
32FGFR11.34890525
33RPS6KA21.33405399
34PDGFRB1.32528571
35EPHB11.32252621
36FGFR21.30742048
37MAP3K31.29138499
38MUSK1.28394819
39MET1.26832372
40EPHA31.26410690
41PTK21.25778609
42NTRK11.25274283
43PRKD31.24821261
44PAK41.24464147
45MTOR1.22928989
46MST1R1.22051311
47GRK61.20252123
48CHUK1.19043264
49KSR11.18414096
50PHKG21.13962752
51PHKG11.13962752
52LMTK21.13033634
53ROCK21.09915185
54PTK61.08996827
55CDC42BPA1.08920536
56PDPK11.07961259
57IRAK41.03583250
58FGR1.01867710
59ROCK10.99132851
60LIMK10.97136769
61MAPK150.93329887
62DYRK1B0.92969571
63NEK10.92907165
64ERBB20.92289015
65SIK30.92126460
66MAP3K100.92093878
67IRAK20.88061206
68ARAF0.86065941
69CSK0.85965887
70BLK0.85246249
71LRRK20.84922818
72MAP2K10.83773171
73CDK60.83595223
74UHMK10.83252850
75TYK20.82922997
76MAP3K10.82135527
77PRKD20.81834587
78EPHA20.81242395
79NTRK20.80987971
80MARK10.80134765
81WNK10.78651344
82MAP2K30.77418421
83MARK20.74151624
84RET0.73379321
85STK30.72562401
86RIPK40.71918497
87ILK0.71264083
88RPS6KL10.69808183
89RPS6KC10.69808183
90CDK140.69431516
91RPS6KB10.69088373
92GSK3A0.68727366
93KSR20.68325542
94TESK20.68310773
95ALK0.68221519
96TAOK10.67680316
97FGFR30.67171180
98JAK10.66161136
99PDK10.65160444
100BCR0.64160211
101FES0.63709355
102DYRK20.63613404
103SGK30.61763897
104BRD40.60911514
105PRKD10.59521461
106MAPKAPK20.58952884
107TNK20.58738495
108STK380.58056583
109CSNK1A1L0.57579205
110MAP3K120.56916756
111CDK150.56575903
112PLK20.56001711
113YES10.55357313
114PTK2B0.53876663
115PKN10.53821604
116SRC0.53464262
117CDK180.52212843
118PRPF4B0.52192305
119INSR0.52070332
120RPS6KA60.52042823
121NME20.50793385
122ERBB40.50603546
123DAPK30.50452886
124RPS6KA10.50088559
125MAP3K90.49535974
126CAMK2B0.47890446
127CDK11A0.47784849
128TBK10.47232352
129IRAK10.46884382
130STK38L0.46564863
131PNCK0.44795444
132CDK70.44719540
133TGFBR20.44691763
134NEK90.44227051
135CAMK2G0.44092989
136MAP3K130.43177452
137MAP3K60.43074463
138PIK3CA0.42692408
139IKBKE0.42570174
140CDK90.40476419
141TIE10.39695800
142ERBB30.38748526
143MAPK10.36938406
144MINK10.36628070
145MAPK100.36048911
146PAK10.35961816
147EEF2K0.35395978
148CSNK1D0.35184690
149MELK0.35142305
150TESK10.34783702
151PRKCZ0.34409851
152FYN0.33570112
153CSNK1G10.32918291
154PRKCE0.32234925
155CAMK2D0.31071339
156ERN10.30883055

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.81302815
2ECM-receptor interaction_Homo sapiens_hsa045122.62986168
3Hedgehog signaling pathway_Homo sapiens_hsa043402.52158316
4Hippo signaling pathway_Homo sapiens_hsa043902.45974171
5Axon guidance_Homo sapiens_hsa043602.12444505
6Focal adhesion_Homo sapiens_hsa045102.11270161
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.09641444
8Adherens junction_Homo sapiens_hsa045202.07893657
9Dilated cardiomyopathy_Homo sapiens_hsa054141.92722174
10Proteoglycans in cancer_Homo sapiens_hsa052051.88643175
11Acute myeloid leukemia_Homo sapiens_hsa052211.82686135
12TGF-beta signaling pathway_Homo sapiens_hsa043501.80366162
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.69303258
14Viral myocarditis_Homo sapiens_hsa054161.68362677
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67921069
16MicroRNAs in cancer_Homo sapiens_hsa052061.65867073
17Tight junction_Homo sapiens_hsa045301.62968486
18Thyroid cancer_Homo sapiens_hsa052161.61906922
19Notch signaling pathway_Homo sapiens_hsa043301.61800120
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.61171819
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.61125569
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59674186
23Wnt signaling pathway_Homo sapiens_hsa043101.58967557
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.57664516
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55514725
26Other glycan degradation_Homo sapiens_hsa005111.54707619
27Melanogenesis_Homo sapiens_hsa049161.42218634
28Protein digestion and absorption_Homo sapiens_hsa049741.36977835
29Glioma_Homo sapiens_hsa052141.36405127
30Renal cell carcinoma_Homo sapiens_hsa052111.35784061
31Bladder cancer_Homo sapiens_hsa052191.34594490
32Amoebiasis_Homo sapiens_hsa051461.29223375
33Melanoma_Homo sapiens_hsa052181.26754626
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26420475
35Gap junction_Homo sapiens_hsa045401.25355135
36Small cell lung cancer_Homo sapiens_hsa052221.25276045
37Colorectal cancer_Homo sapiens_hsa052101.22591269
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.19884381
39Endometrial cancer_Homo sapiens_hsa052131.17390699
40Fatty acid biosynthesis_Homo sapiens_hsa000611.17358350
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16935757
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.16493024
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15242214
44Pathways in cancer_Homo sapiens_hsa052001.14363733
45Chronic myeloid leukemia_Homo sapiens_hsa052201.13556025
46B cell receptor signaling pathway_Homo sapiens_hsa046621.13530827
47Prolactin signaling pathway_Homo sapiens_hsa049171.13182501
48Hepatitis C_Homo sapiens_hsa051601.09083381
49Osteoclast differentiation_Homo sapiens_hsa043801.08905945
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.08379612
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06615799
52Inositol phosphate metabolism_Homo sapiens_hsa005621.05911008
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04891961
54mTOR signaling pathway_Homo sapiens_hsa041501.04216743
55AMPK signaling pathway_Homo sapiens_hsa041521.04074440
56Toxoplasmosis_Homo sapiens_hsa051451.03247024
57Dorso-ventral axis formation_Homo sapiens_hsa043201.00238143
58Lysosome_Homo sapiens_hsa041421.00127433
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99238430
60Estrogen signaling pathway_Homo sapiens_hsa049150.98990228
61Leishmaniasis_Homo sapiens_hsa051400.98517002
62Rap1 signaling pathway_Homo sapiens_hsa040150.97574981
63Renin secretion_Homo sapiens_hsa049240.93310023
64Lysine degradation_Homo sapiens_hsa003100.93135877
65ErbB signaling pathway_Homo sapiens_hsa040120.92646618
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90411290
67Pancreatic cancer_Homo sapiens_hsa052120.89841770
68Prostate cancer_Homo sapiens_hsa052150.88547699
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.88069701
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84673138
71Nitrogen metabolism_Homo sapiens_hsa009100.83931715
72GnRH signaling pathway_Homo sapiens_hsa049120.83410060
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83318123
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82133561
75Tuberculosis_Homo sapiens_hsa051520.81950553
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81826088
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81586959
78Oxytocin signaling pathway_Homo sapiens_hsa049210.81531497
79Ovarian steroidogenesis_Homo sapiens_hsa049130.80895002
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80014137
81Chemokine signaling pathway_Homo sapiens_hsa040620.77770516
82Pentose phosphate pathway_Homo sapiens_hsa000300.76594146
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75516399
84Staphylococcus aureus infection_Homo sapiens_hsa051500.75510304
85Endocytosis_Homo sapiens_hsa041440.73655242
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72970874
87VEGF signaling pathway_Homo sapiens_hsa043700.71731117
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71255618
89Long-term depression_Homo sapiens_hsa047300.70370078
90Prion diseases_Homo sapiens_hsa050200.69931774
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69038757
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68445375
93Bile secretion_Homo sapiens_hsa049760.68318763
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68287616
95Ras signaling pathway_Homo sapiens_hsa040140.68189247
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67642259
97Hepatitis B_Homo sapiens_hsa051610.67325494
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.65924210
99cAMP signaling pathway_Homo sapiens_hsa040240.65819863
100FoxO signaling pathway_Homo sapiens_hsa040680.64700954
101GABAergic synapse_Homo sapiens_hsa047270.64247571
102Insulin signaling pathway_Homo sapiens_hsa049100.64085447
103Choline metabolism in cancer_Homo sapiens_hsa052310.64001960
104Vibrio cholerae infection_Homo sapiens_hsa051100.63053655
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.62778729
106HTLV-I infection_Homo sapiens_hsa051660.61958690
107HIF-1 signaling pathway_Homo sapiens_hsa040660.61736237
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.61030289
109Influenza A_Homo sapiens_hsa051640.60945928
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60505754
111Fatty acid metabolism_Homo sapiens_hsa012120.60366338
112Circadian entrainment_Homo sapiens_hsa047130.60183198
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.59611588
114Non-small cell lung cancer_Homo sapiens_hsa052230.59259827
115Malaria_Homo sapiens_hsa051440.59091327
116Oocyte meiosis_Homo sapiens_hsa041140.57711385
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57544979
118Gastric acid secretion_Homo sapiens_hsa049710.56956533
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55742095
120Cholinergic synapse_Homo sapiens_hsa047250.55448980
121MAPK signaling pathway_Homo sapiens_hsa040100.55182447
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.54340040
123T cell receptor signaling pathway_Homo sapiens_hsa046600.53893683
124Type II diabetes mellitus_Homo sapiens_hsa049300.53523916
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51399225
126Apoptosis_Homo sapiens_hsa042100.51079312
127Galactose metabolism_Homo sapiens_hsa000520.50084559
128Phagosome_Homo sapiens_hsa041450.49894619
129Insulin resistance_Homo sapiens_hsa049310.49882244
130PPAR signaling pathway_Homo sapiens_hsa033200.49622384
131Dopaminergic synapse_Homo sapiens_hsa047280.47706867
132Salivary secretion_Homo sapiens_hsa049700.47228938
133Platelet activation_Homo sapiens_hsa046110.43346338
134Glutamatergic synapse_Homo sapiens_hsa047240.42431881

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