SULT1A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)3.59346446
2diacylglycerol metabolic process (GO:0046339)3.39993212
3sulfation (GO:0051923)3.28774961
4fucose catabolic process (GO:0019317)3.25170482
5L-fucose metabolic process (GO:0042354)3.25170482
6L-fucose catabolic process (GO:0042355)3.25170482
7female mating behavior (GO:0060180)3.14177143
8alkaloid metabolic process (GO:0009820)3.05653979
9negative regulation of macrophage differentiation (GO:0045650)3.04475916
10regulation of guanylate cyclase activity (GO:0031282)3.04047874
11cell wall macromolecule metabolic process (GO:0044036)2.99875821
12DNA deamination (GO:0045006)2.99141024
13response to interferon-beta (GO:0035456)2.98731983
14regulation of autophagic vacuole assembly (GO:2000785)2.97768253
15mast cell activation involved in immune response (GO:0002279)2.94600016
16mast cell degranulation (GO:0043303)2.94600016
17positive regulation of antigen processing and presentation (GO:0002579)2.84514146
18negative regulation of granulocyte differentiation (GO:0030853)2.79190138
19respiratory chain complex IV assembly (GO:0008535)2.78780957
20tryptophan catabolic process (GO:0006569)2.78599464
21indole-containing compound catabolic process (GO:0042436)2.78599464
22indolalkylamine catabolic process (GO:0046218)2.78599464
23protein complex biogenesis (GO:0070271)2.78410461
24GDP-mannose metabolic process (GO:0019673)2.76894916
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76573643
26cytochrome complex assembly (GO:0017004)2.76005390
27regulation of triglyceride catabolic process (GO:0010896)2.75937337
28mitochondrial respiratory chain complex I assembly (GO:0032981)2.75641026
29NADH dehydrogenase complex assembly (GO:0010257)2.75641026
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.75641026
31mast cell activation (GO:0045576)2.74176570
32regulation of hydrogen peroxide metabolic process (GO:0010310)2.72885406
33antigen processing and presentation of endogenous antigen (GO:0019883)2.69105776
34quinone biosynthetic process (GO:1901663)2.68625608
35multicellular organism reproduction (GO:0032504)2.67932040
36glutathione biosynthetic process (GO:0006750)2.66387428
37positive regulation of guanylate cyclase activity (GO:0031284)2.65568638
38indolalkylamine metabolic process (GO:0006586)2.64895315
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64827591
40regulation of granulocyte differentiation (GO:0030852)2.64612840
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.64041285
42regulation of female receptivity (GO:0045924)2.63542039
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.62453164
44negative regulation of cell killing (GO:0031342)2.62453164
45positive regulation of gamma-delta T cell activation (GO:0046645)2.61151272
46fucosylation (GO:0036065)2.59483050
47nonribosomal peptide biosynthetic process (GO:0019184)2.56354551
48behavioral response to nicotine (GO:0035095)2.56345850
49coenzyme catabolic process (GO:0009109)2.56242682
50phosphatidylethanolamine biosynthetic process (GO:0006646)2.55767827
513-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.54623195
52purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.54623195
53regulation of cellular extravasation (GO:0002691)2.53242631
54negative regulation of telomere maintenance (GO:0032205)2.52893921
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52074725
56immunoglobulin mediated immune response (GO:0016064)2.51597385
57regulation of respiratory burst (GO:0060263)2.49934854
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.49555596
59regulation of ARF GTPase activity (GO:0032312)2.48564687
60cellular response to interferon-beta (GO:0035458)2.48474795
61cellular response to exogenous dsRNA (GO:0071360)2.47759334
62ATP synthesis coupled proton transport (GO:0015986)2.47150327
63energy coupled proton transport, down electrochemical gradient (GO:0015985)2.47150327
64amine catabolic process (GO:0009310)2.44811493
65cellular biogenic amine catabolic process (GO:0042402)2.44811493
66pyrimidine nucleotide catabolic process (GO:0006244)2.44611717
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43804859
68regulation of vacuole organization (GO:0044088)2.43794677
69deoxyribonucleotide catabolic process (GO:0009264)2.43363033
70positive regulation of respiratory burst (GO:0060267)2.43156454
71rRNA methylation (GO:0031167)2.41292424
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.40398912
73mitochondrial respiratory chain complex assembly (GO:0033108)2.39346455
74rRNA modification (GO:0000154)2.38178588
75regulation of antigen processing and presentation (GO:0002577)2.37214291
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35512157
77modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35512157
78positive regulation by organism of defense response of other organism involved in symbiotic interact2.35512157
79modulation by symbiont of host immune response (GO:0052553)2.35512157
80positive regulation by symbiont of host defense response (GO:0052509)2.35512157
81modulation by symbiont of host defense response (GO:0052031)2.35512157
82cofactor catabolic process (GO:0051187)2.35452892
83positive regulation of B cell differentiation (GO:0045579)2.35419781
84NAD biosynthetic process (GO:0009435)2.32273783
85arginine metabolic process (GO:0006525)2.30447642
86mannose metabolic process (GO:0006013)2.30059762
87base-excision repair, AP site formation (GO:0006285)2.29639594
88response to acidic pH (GO:0010447)2.29456441
89sulfate transmembrane transport (GO:1902358)2.29233522
90positive regulation of T cell mediated cytotoxicity (GO:0001916)2.29178733
91positive regulation of granulocyte differentiation (GO:0030854)2.28663897
92positive regulation of protein homooligomerization (GO:0032464)2.28091280
93purinergic nucleotide receptor signaling pathway (GO:0035590)2.27520265
94high-density lipoprotein particle remodeling (GO:0034375)2.27373867
95cytidine deamination (GO:0009972)2.27356437
96cytidine metabolic process (GO:0046087)2.27356437
97cytidine catabolic process (GO:0006216)2.27356437
98deoxyribose phosphate catabolic process (GO:0046386)2.25946585
99phosphatidylethanolamine metabolic process (GO:0046337)2.24960367
100tryptophan metabolic process (GO:0006568)2.24822993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.52270746
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.07620956
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.42907984
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67079887
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.51328005
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49586152
7BCL6_27268052_Chip-Seq_Bcells_Human2.24434123
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.24206444
9EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.04010381
10BCOR_27268052_Chip-Seq_Bcells_Human1.96560914
11ERA_21632823_ChIP-Seq_H3396_Human1.96196406
12E2F1_20622854_ChIP-Seq_HELA_Human1.94201896
13VDR_22108803_ChIP-Seq_LS180_Human1.92519931
14IRF8_21731497_ChIP-ChIP_J774_Mouse1.88094069
15P68_20966046_ChIP-Seq_HELA_Human1.82871076
16PHF8_20622854_ChIP-Seq_HELA_Human1.82019258
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80530612
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.76415513
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.75001812
20ELF1_20517297_ChIP-Seq_JURKAT_Human1.74542361
21SCL_19346495_ChIP-Seq_HPC-7_Human1.71454069
22CTCF_20526341_ChIP-Seq_ESCs_Human1.68903987
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66102244
24NANOG_20526341_ChIP-Seq_ESCs_Human1.65257164
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63937149
26RAC3_21632823_ChIP-Seq_H3396_Human1.62702821
27VDR_21846776_ChIP-Seq_THP-1_Human1.62146540
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61733636
29ZNF274_21170338_ChIP-Seq_K562_Hela1.61683641
30SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.61559576
31P300_27268052_Chip-Seq_Bcells_Human1.60794662
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59395474
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59053870
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58514503
35ETV2_25802403_ChIP-Seq_MESCs_Mouse1.58236465
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57993847
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54238597
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53142613
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.53055410
40STAT1_20625510_ChIP-Seq_HELA_Human1.48911326
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.48742789
42SA1_27219007_Chip-Seq_Bcells_Human1.47932598
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46667334
44LXR_22292898_ChIP-Seq_THP-1_Human1.44494638
45* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.44255793
46CTCF_27219007_Chip-Seq_Bcells_Human1.41776227
47OCT4_20526341_ChIP-Seq_ESCs_Human1.39479789
48* MAF_26560356_Chip-Seq_TH2_Human1.37671352
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35181164
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34953944
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28814519
52MYC_19829295_ChIP-Seq_ESCs_Human1.27033659
53DROSHA_22980978_ChIP-Seq_HELA_Human1.26651824
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.26592237
55OCT4_19829295_ChIP-Seq_ESCs_Human1.25523858
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24960460
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.23649104
58TAF2_19829295_ChIP-Seq_ESCs_Human1.23245696
59SMC4_20622854_ChIP-Seq_HELA_Human1.21400764
60EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20992393
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20643875
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20220940
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19975252
64GATA3_26560356_Chip-Seq_TH2_Human1.19524313
65CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19340169
66RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18078682
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17699405
68RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17570322
69CTCF_26484167_Chip-Seq_Bcells_Mouse1.17398184
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.17154868
71* FOXP1_21924763_ChIP-Seq_HESCs_Human1.15525415
72UTX_26944678_Chip-Seq_JUKART_Human1.15089429
73CIITA_25753668_ChIP-Seq_RAJI_Human1.14934359
74SPI1_23547873_ChIP-Seq_NB4_Human1.14750893
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12800816
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12558424
77NCOR_22424771_ChIP-Seq_293T_Human1.11574294
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09748079
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.08749620
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08532613
81VDR_24763502_ChIP-Seq_THP-1_Human1.07976019
82P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07727391
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.07036341
84P53_21459846_ChIP-Seq_SAOS-2_Human1.06881965
85SPI1_20517297_ChIP-Seq_HL60_Human1.06852022
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06491609
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06427988
88RARB_24833708_ChIP-Seq_LIVER_Mouse1.06245781
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05548034
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05076419
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04341613
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03622642
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02006339
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01532613
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01450898
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01231126
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00703142
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99787704
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.99547151
100EZH2_22144423_ChIP-Seq_EOC_Human0.97268435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.73018090
2MP0005360_urolithiasis3.37439300
3MP0002132_abnormal_respiratory_system2.54277912
4MP0003136_yellow_coat_color2.47921618
5MP0003724_increased_susceptibility_to2.13345760
6MP0008875_abnormal_xenobiotic_pharmacok2.10898060
7MP0001835_abnormal_antigen_presentation1.96484619
8MP0003436_decreased_susceptibility_to1.94782132
9MP0005671_abnormal_response_to1.92779530
10MP0001986_abnormal_taste_sensitivity1.89486343
11MP0003787_abnormal_imprinting1.83607644
12MP0004381_abnormal_hair_follicle1.81934887
13MP0003878_abnormal_ear_physiology1.79877361
14MP0005377_hearing/vestibular/ear_phenot1.79877361
15MP0001800_abnormal_humoral_immune1.77058033
16MP0003172_abnormal_lysosome_physiology1.70956947
17MP0005410_abnormal_fertilization1.69274319
18MP0005365_abnormal_bile_salt1.68086257
19MP0008872_abnormal_physiological_respon1.65718858
20MP0002138_abnormal_hepatobiliary_system1.65271818
21MP0006036_abnormal_mitochondrial_physio1.62273034
22MP0000015_abnormal_ear_pigmentation1.60364960
23MP0005085_abnormal_gallbladder_physiolo1.58997800
24MP0005084_abnormal_gallbladder_morpholo1.55687733
25MP0002876_abnormal_thyroid_physiology1.52984038
26MP0005025_abnormal_response_to1.52481647
27MP0005387_immune_system_phenotype1.52299927
28MP0001790_abnormal_immune_system1.52299927
29MP0003866_abnormal_defecation1.49778256
30MP0002148_abnormal_hypersensitivity_rea1.49444892
31MP0001485_abnormal_pinna_reflex1.48881761
32MP0005174_abnormal_tail_pigmentation1.48733455
33MP0004019_abnormal_vitamin_homeostasis1.47544372
34MP0000685_abnormal_immune_system1.47050839
35MP0009764_decreased_sensitivity_to1.46592990
36MP0009785_altered_susceptibility_to1.46584264
37MP0002139_abnormal_hepatobiliary_system1.46568649
38MP0003879_abnormal_hair_cell1.46129696
39MP0009840_abnormal_foam_cell1.45972383
40MP0001666_abnormal_nutrient_absorption1.45874138
41MP0002723_abnormal_immune_serum1.45107196
42MP0005551_abnormal_eye_electrophysiolog1.43292023
43MP0005000_abnormal_immune_tolerance1.38882282
44MP0005075_abnormal_melanosome_morpholog1.38138631
45MP0002420_abnormal_adaptive_immunity1.37609644
46MP0001819_abnormal_immune_cell1.37493969
47MP0002419_abnormal_innate_immunity1.37206086
48MP0001873_stomach_inflammation1.36230671
49MP0010155_abnormal_intestine_physiology1.35812344
50MP0002452_abnormal_antigen_presenting1.34278929
51MP0006035_abnormal_mitochondrial_morpho1.32443417
52MP0005058_abnormal_lysosome_morphology1.31649115
53MP0005464_abnormal_platelet_physiology1.28884640
54MP0010329_abnormal_lipoprotein_level1.28582267
55MP0001764_abnormal_homeostasis1.26195324
56MP0003195_calcinosis1.25297988
57MP0000372_irregular_coat_pigmentation1.23689889
58MP0002277_abnormal_respiratory_mucosa1.15457130
59MP0008877_abnormal_DNA_methylation1.14029092
60MP0004147_increased_porphyrin_level1.10774476
61MP0005646_abnormal_pituitary_gland1.09392812
62MP0001968_abnormal_touch/_nociception1.05792662
63MP0001501_abnormal_sleep_pattern1.05174831
64MP0001845_abnormal_inflammatory_respons1.02920341
65MP0002822_catalepsy1.02322251
66MP0006082_CNS_inflammation1.01277527
67MP0004133_heterotaxia0.98208886
68MP0000716_abnormal_immune_system0.97123852
69MP0004043_abnormal_pH_regulation0.96970875
70MP0002837_dystrophic_cardiac_calcinosis0.95703896
71MP0003763_abnormal_thymus_physiology0.95630561
72MP0005636_abnormal_mineral_homeostasis0.95201780
73MP0001663_abnormal_digestive_system0.93535047
74MP0005083_abnormal_biliary_tract0.93469981
75MP0001664_abnormal_digestion0.93374341
76MP0004742_abnormal_vestibular_system0.92952638
77MP0008469_abnormal_protein_level0.92105007
78MP0003252_abnormal_bile_duct0.91772563
79MP0003183_abnormal_peptide_metabolism0.90729014
80MP0002653_abnormal_ependyma_morphology0.89339219
81MP0002160_abnormal_reproductive_system0.89332878
82MP0001756_abnormal_urination0.86328770
83MP0000689_abnormal_spleen_morphology0.85633116
84MP0001533_abnormal_skeleton_physiology0.84366996
85MP0002398_abnormal_bone_marrow0.83885947
86MP0001765_abnormal_ion_homeostasis0.83654153
87MP0000230_abnormal_systemic_arterial0.83215276
88MP0002272_abnormal_nervous_system0.83155228
89MP0006292_abnormal_olfactory_placode0.82436832
90MP0006276_abnormal_autonomic_nervous0.81971061
91MP0005319_abnormal_enzyme/_coenzyme0.81812573
92MP0001905_abnormal_dopamine_level0.81229593
93MP0005332_abnormal_amino_acid0.81229550
94MP0000465_gastrointestinal_hemorrhage0.81182518
95MP0008004_abnormal_stomach_pH0.81113864
96MP0001486_abnormal_startle_reflex0.80735914
97MP0009643_abnormal_urine_homeostasis0.80015906
98MP0002405_respiratory_system_inflammati0.79571465
99MP0008260_abnormal_autophagy0.74904093
100MP0002429_abnormal_blood_cell0.74138058

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)3.47274539
2Elevated erythrocyte sedimentation rate (HP:0003565)3.32151372
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.30834702
4Bile duct proliferation (HP:0001408)3.05503186
5Abnormal biliary tract physiology (HP:0012439)3.05503186
6Congenital stationary night blindness (HP:0007642)3.05132506
7Abnormality of midbrain morphology (HP:0002418)2.97672456
8Molar tooth sign on MRI (HP:0002419)2.97672456
9Hepatocellular necrosis (HP:0001404)2.90371379
10Myositis (HP:0100614)2.75728256
11Pancreatic cysts (HP:0001737)2.73104415
12Mitochondrial inheritance (HP:0001427)2.73060674
13Panhypogammaglobulinemia (HP:0003139)2.68530819
14Severe visual impairment (HP:0001141)2.64004797
15Stomatitis (HP:0010280)2.58253851
16Increased CSF lactate (HP:0002490)2.47913307
17Hepatic necrosis (HP:0002605)2.47286022
18Pustule (HP:0200039)2.42411453
19Nephronophthisis (HP:0000090)2.39010453
20Clumsiness (HP:0002312)2.37354468
21Attenuation of retinal blood vessels (HP:0007843)2.35795520
22Pancreatic fibrosis (HP:0100732)2.35011346
23True hermaphroditism (HP:0010459)2.34667262
24Chronic hepatic failure (HP:0100626)2.32415368
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30856417
26Type II lissencephaly (HP:0007260)2.30467790
27Acute necrotizing encephalopathy (HP:0006965)2.24299180
28Petechiae (HP:0000967)2.23647880
29Cystic liver disease (HP:0006706)2.17924755
30Acute encephalopathy (HP:0006846)2.15488975
31Abnormality of DNA repair (HP:0003254)2.13581472
32Abnormal mitochondria in muscle tissue (HP:0008316)2.12654679
33Congenital sensorineural hearing impairment (HP:0008527)2.12527747
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12452433
35Hypochromic anemia (HP:0001931)2.11129390
36Recurrent fungal infections (HP:0002841)2.10434483
37Aplasia/Hypoplasia of the spleen (HP:0010451)2.09331681
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.07690879
39Obstructive lung disease (HP:0006536)2.07493971
40Chronic obstructive pulmonary disease (HP:0006510)2.07493971
41Abnormality of pyrimidine metabolism (HP:0004353)2.06001951
42Orchitis (HP:0100796)2.05477098
43Recurrent abscess formation (HP:0002722)2.05377728
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05354857
45Abolished electroretinogram (ERG) (HP:0000550)2.05108784
46Recurrent bacterial skin infections (HP:0005406)2.04797373
47Asplenia (HP:0001746)2.04678164
48Ketosis (HP:0001946)2.04403539
49Optic neuritis (HP:0100653)2.04086565
50Retrobulbar optic neuritis (HP:0100654)2.04086565
51Decreased central vision (HP:0007663)2.01797697
52Abnormality of the renal medulla (HP:0100957)2.00716422
53Prolonged bleeding time (HP:0003010)1.99823950
54Pigmentary retinal degeneration (HP:0001146)1.99694618
55Encephalitis (HP:0002383)1.99354068
56Abnormality of dental color (HP:0011073)1.98770536
57Optic disc pallor (HP:0000543)1.96974075
58Abnormal number of erythroid precursors (HP:0012131)1.96691240
59Granulocytopenia (HP:0001913)1.94515261
60Absent thumb (HP:0009777)1.91319345
61Hyperglycinuria (HP:0003108)1.90779522
62Systemic lupus erythematosus (HP:0002725)1.90660506
63Abnormality of transition element cation homeostasis (HP:0011030)1.90218350
64Abnormality of urine glucose concentration (HP:0011016)1.89288847
65Glycosuria (HP:0003076)1.89288847
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89026652
67Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89026652
68Eosinophilia (HP:0001880)1.88511112
69Keratoconjunctivitis (HP:0001096)1.87754655
70Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87187318
71Dicarboxylic aciduria (HP:0003215)1.87187318
72Chronic mucocutaneous candidiasis (HP:0002728)1.85706754
73Recurrent cutaneous fungal infections (HP:0011370)1.85706754
74Methylmalonic aciduria (HP:0012120)1.85501228
75Lipid accumulation in hepatocytes (HP:0006561)1.85329128
76Cerebral palsy (HP:0100021)1.85281702
77Concave nail (HP:0001598)1.84808936
78Malnutrition (HP:0004395)1.84394143
79Increased serum ferritin (HP:0003281)1.84287890
80IgG deficiency (HP:0004315)1.78164974
813-Methylglutaconic aciduria (HP:0003535)1.77913853
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76674268
83Absent/shortened dynein arms (HP:0200106)1.74840574
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.74840574
85Increased neuronal autofluorescent lipopigment (HP:0002074)1.73456459
86Hyperglycinemia (HP:0002154)1.73372648
87Increased muscle lipid content (HP:0009058)1.73126027
88Lactic acidosis (HP:0003128)1.73114827
89Abnormality of serine family amino acid metabolism (HP:0010894)1.73090941
90Abnormality of glycine metabolism (HP:0010895)1.73090941
91Tetany (HP:0001281)1.72034702
92Vasculitis (HP:0002633)1.70714803
93Progressive macrocephaly (HP:0004481)1.70233775
94Abnormality of the heme biosynthetic pathway (HP:0010472)1.70017894
95Rib fusion (HP:0000902)1.69553762
96Abnormality of iron homeostasis (HP:0011031)1.68647913
97Leukocytosis (HP:0001974)1.65903951
98Male pseudohermaphroditism (HP:0000037)1.65399484
99Increased serum lactate (HP:0002151)1.65104969
100Lethargy (HP:0001254)1.64621104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.96134025
2TLK13.20705929
3MAP4K12.75745995
4TXK2.65121725
5WNK42.54987905
6TNK22.45925210
7SIK22.37210190
8GRK62.35258247
9NME12.18095159
10FRK2.17116607
11MAP4K22.16333938
12MARK32.13475195
13RIPK41.93211435
14INSRR1.88183224
15NME21.83511124
16ADRBK21.71939085
17GRK11.70660277
18MAP2K61.70558618
19SYK1.65217510
20BTK1.61096614
21BLK1.60842951
22FES1.58268959
23TYK21.57157545
24BMPR1B1.56865356
25TAOK31.55620878
26ACVR1B1.50184228
27ERN11.41925046
28ZAK1.38675188
29MAPK151.38561763
30OXSR11.25045593
31TNIK1.22031263
32PRKCQ1.21273727
33KIT1.19309550
34ZAP701.18487533
35TEC1.16337542
36BCKDK1.11515866
37ITK1.11420020
38IKBKB1.05807363
39LYN1.02224013
40MAP3K110.96057163
41MAP2K20.95626220
42NUAK10.94637673
43IRAK40.90873971
44IKBKE0.90804503
45MUSK0.90684921
46PRKG20.90470637
47DYRK20.89678777
48CDK190.87843928
49MAPKAPK30.86398852
50MAP2K30.86070431
51MAPK130.85613719
52PDK20.85059908
53TBK10.82773028
54STK390.80932093
55DAPK20.80745981
56NEK20.79169866
57CSF1R0.78014992
58MAP2K70.77040782
59LCK0.73541428
60HCK0.72843037
61MAP3K10.70374283
62MST1R0.68093142
63MATK0.67739618
64CSK0.66356219
65VRK20.66353205
66WNK30.64780378
67PDK10.64487051
68PDPK10.60095455
69MAPK120.59293347
70ADRBK10.57621883
71PRKCI0.55394306
72RPS6KA60.54578075
73PTK2B0.54255153
74CSNK1G30.54151892
75GRK50.52611086
76FGR0.51167404
77DAPK10.49378957
78STK380.49201105
79JAK30.46640887
80PRKCZ0.45752298
81NTRK30.45248832
82TAOK10.45164852
83PIM20.43098667
84MAPK110.43018523
85GRK70.42759983
86RPS6KA20.42567972
87FGFR20.41448217
88RPS6KA50.41017214
89RPS6KL10.40951685
90RPS6KC10.40951685
91PAK30.40763326
92NTRK20.40248110
93CDK30.38127460
94PRKCG0.37600064
95KDR0.36298644
96MAP3K30.35837703
97CDC42BPA0.35764581
98SIK10.35717344
99PRKCD0.35070876
100ABL20.35053048

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046722.81913821
2Asthma_Homo sapiens_hsa053102.73028414
3Allograft rejection_Homo sapiens_hsa053302.38904435
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.24737696
5Primary immunodeficiency_Homo sapiens_hsa053402.23695214
6Staphylococcus aureus infection_Homo sapiens_hsa051502.23220358
7Oxidative phosphorylation_Homo sapiens_hsa001902.20980579
8Sulfur relay system_Homo sapiens_hsa041222.19064762
9Autoimmune thyroid disease_Homo sapiens_hsa053202.15379228
10Graft-versus-host disease_Homo sapiens_hsa053322.12497152
11* Chemical carcinogenesis_Homo sapiens_hsa052042.02956103
12Fat digestion and absorption_Homo sapiens_hsa049751.98777821
13Vitamin digestion and absorption_Homo sapiens_hsa049771.98629149
14Linoleic acid metabolism_Homo sapiens_hsa005911.85052233
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80355573
16Phototransduction_Homo sapiens_hsa047441.78355133
17Parkinsons disease_Homo sapiens_hsa050121.73085978
18Type I diabetes mellitus_Homo sapiens_hsa049401.71738866
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.68181519
20Other glycan degradation_Homo sapiens_hsa005111.62609030
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.62110323
22Regulation of autophagy_Homo sapiens_hsa041401.58223799
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51843141
24Caffeine metabolism_Homo sapiens_hsa002321.49354129
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46608631
26Olfactory transduction_Homo sapiens_hsa047401.45515583
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38866290
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36441720
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.35512538
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34208022
31Arachidonic acid metabolism_Homo sapiens_hsa005901.33106045
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.31141545
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30129633
34Fanconi anemia pathway_Homo sapiens_hsa034601.25119810
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.21687539
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21669750
37Tryptophan metabolism_Homo sapiens_hsa003801.16009287
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.14295390
39RNA polymerase_Homo sapiens_hsa030201.13407056
40Antigen processing and presentation_Homo sapiens_hsa046121.13015026
41Nitrogen metabolism_Homo sapiens_hsa009101.11797794
42Leishmaniasis_Homo sapiens_hsa051401.11328737
43Peroxisome_Homo sapiens_hsa041461.10386904
44Hematopoietic cell lineage_Homo sapiens_hsa046401.09492752
45Glycerolipid metabolism_Homo sapiens_hsa005611.08038586
46Ribosome_Homo sapiens_hsa030101.06748266
47Retinol metabolism_Homo sapiens_hsa008301.06613066
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03926376
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01630524
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.01343129
51Mineral absorption_Homo sapiens_hsa049780.96512737
52Butanoate metabolism_Homo sapiens_hsa006500.96117049
53ABC transporters_Homo sapiens_hsa020100.96063617
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93413422
55Alzheimers disease_Homo sapiens_hsa050100.92884772
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92815633
57Ether lipid metabolism_Homo sapiens_hsa005650.91123272
58Collecting duct acid secretion_Homo sapiens_hsa049660.90629713
59Rheumatoid arthritis_Homo sapiens_hsa053230.89770137
60Huntingtons disease_Homo sapiens_hsa050160.84275814
61Histidine metabolism_Homo sapiens_hsa003400.81880439
62Homologous recombination_Homo sapiens_hsa034400.81177884
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79509526
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78980228
65Proteasome_Homo sapiens_hsa030500.77078123
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74788166
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71199368
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70988578
69Pyrimidine metabolism_Homo sapiens_hsa002400.70578985
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69866735
71Tuberculosis_Homo sapiens_hsa051520.68118080
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66244642
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63478176
74Glutathione metabolism_Homo sapiens_hsa004800.63285596
75Arginine biosynthesis_Homo sapiens_hsa002200.62481240
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.62201989
77Metabolic pathways_Homo sapiens_hsa011000.59331484
78Fructose and mannose metabolism_Homo sapiens_hsa000510.58433459
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58108037
80Osteoclast differentiation_Homo sapiens_hsa043800.57327837
81Salivary secretion_Homo sapiens_hsa049700.57260213
82Herpes simplex infection_Homo sapiens_hsa051680.57044709
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56545160
84Starch and sucrose metabolism_Homo sapiens_hsa005000.55190214
85African trypanosomiasis_Homo sapiens_hsa051430.51793823
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51695647
87B cell receptor signaling pathway_Homo sapiens_hsa046620.50754565
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50068246
89Taste transduction_Homo sapiens_hsa047420.45733475
90Complement and coagulation cascades_Homo sapiens_hsa046100.43133828
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42579134
92Fatty acid degradation_Homo sapiens_hsa000710.42142694
93Pertussis_Homo sapiens_hsa051330.41791455
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40022445
95T cell receptor signaling pathway_Homo sapiens_hsa046600.39858176
96PPAR signaling pathway_Homo sapiens_hsa033200.38898243
97Sulfur metabolism_Homo sapiens_hsa009200.38323658
98Lysosome_Homo sapiens_hsa041420.36614242
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.36423046
100Purine metabolism_Homo sapiens_hsa002300.36080737

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