SULT1A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)5.69518564
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.21593148
3plasma lipoprotein particle assembly (GO:0034377)4.54417396
4very-low-density lipoprotein particle assembly (GO:0034379)4.47482576
5intestinal absorption (GO:0050892)4.40495866
6lipoprotein transport (GO:0042953)4.31145818
7antigen processing and presentation of endogenous antigen (GO:0019883)4.27722627
8diacylglycerol metabolic process (GO:0046339)4.13269401
9fat-soluble vitamin biosynthetic process (GO:0042362)4.11660920
10protein-lipid complex assembly (GO:0065005)4.11196660
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06015657
12regulation of cellular extravasation (GO:0002691)4.01984069
13regulation of cholesterol esterification (GO:0010872)3.99753549
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.94694527
15regulation of bile acid biosynthetic process (GO:0070857)3.86144302
16regulation of guanylate cyclase activity (GO:0031282)3.76666823
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.71233524
18negative regulation of cell killing (GO:0031342)3.56624297
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56624297
20neutrophil activation involved in immune response (GO:0002283)3.56458319
21detection of bacterium (GO:0016045)3.53400721
22phospholipid efflux (GO:0033700)3.52638284
23NADH metabolic process (GO:0006734)3.52328226
24detection of other organism (GO:0098543)3.47235748
25immunoglobulin mediated immune response (GO:0016064)3.46341356
26low-density lipoprotein particle remodeling (GO:0034374)3.46268580
27epoxygenase P450 pathway (GO:0019373)3.30107818
28positive regulation of lipoprotein lipase activity (GO:0051006)3.28121298
29positive regulation of triglyceride lipase activity (GO:0061365)3.28121298
30plasma lipoprotein particle organization (GO:0071827)3.24717890
31positive regulation by symbiont of host defense response (GO:0052509)3.23302018
32modulation by symbiont of host defense response (GO:0052031)3.23302018
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.23302018
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.23302018
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.23302018
36modulation by symbiont of host immune response (GO:0052553)3.23302018
37regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.21530491
38endocrine process (GO:0050886)3.21530491
39regulation of systemic arterial blood pressure by hormone (GO:0001990)3.21530491
40plasma lipoprotein particle remodeling (GO:0034369)3.19521066
41protein-lipid complex remodeling (GO:0034368)3.19521066
42macromolecular complex remodeling (GO:0034367)3.19521066
43positive regulation of gamma-delta T cell activation (GO:0046645)3.17828806
44positive regulation of respiratory burst (GO:0060267)3.13678538
45peptide catabolic process (GO:0043171)3.10497378
46protein-lipid complex subunit organization (GO:0071825)3.09003519
47regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08365130
48glycosphingolipid catabolic process (GO:0046479)3.04707512
49high-density lipoprotein particle remodeling (GO:0034375)3.03538671
50lipoprotein metabolic process (GO:0042157)3.01285158
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.01213173
52cholesterol efflux (GO:0033344)3.01189633
53regulation of triglyceride catabolic process (GO:0010896)2.99699867
54positive regulation of Cdc42 GTPase activity (GO:0043089)2.94340272
55hormone catabolic process (GO:0042447)2.92877087
56maintenance of gastrointestinal epithelium (GO:0030277)2.91171709
57positive regulation of antigen processing and presentation (GO:0002579)2.87448882
58glycolipid catabolic process (GO:0019377)2.87336451
59response to peptidoglycan (GO:0032494)2.86579551
60positive regulation of guanylate cyclase activity (GO:0031284)2.83316561
61fructose metabolic process (GO:0006000)2.82093385
62regulation of systemic arterial blood pressure (GO:0003073)2.79911492
63GDP-mannose metabolic process (GO:0019673)2.76428220
64bile acid and bile salt transport (GO:0015721)2.73797174
65regulation of mast cell degranulation (GO:0043304)2.69591534
66leukotriene metabolic process (GO:0006691)2.66650691
67regulation of cytokine secretion involved in immune response (GO:0002739)2.66428063
68regulation of gamma-delta T cell activation (GO:0046643)2.66190090
69detection of external biotic stimulus (GO:0098581)2.65359122
70B cell mediated immunity (GO:0019724)2.64775320
71macrophage activation involved in immune response (GO:0002281)2.63238980
72regulation of antigen processing and presentation (GO:0002577)2.62758484
73urea cycle (GO:0000050)2.61554911
74regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60538734
75negative regulation of interleukin-12 production (GO:0032695)2.58718694
76drug transport (GO:0015893)2.58011035
77neutrophil activation (GO:0042119)2.57136710
78positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.57070366
79reverse cholesterol transport (GO:0043691)2.56328102
80antigen processing and presentation via MHC class Ib (GO:0002475)2.55688949
81respiratory burst (GO:0045730)2.55352997
82interferon-gamma-mediated signaling pathway (GO:0060333)2.55126491
83flavonoid metabolic process (GO:0009812)2.54250594
84regulation of cholesterol homeostasis (GO:2000188)2.53531546
85regulation of superoxide anion generation (GO:0032928)2.52503054
86positive regulation of fatty acid biosynthetic process (GO:0045723)2.50673090
87uronic acid metabolic process (GO:0006063)2.50109394
88glucuronate metabolic process (GO:0019585)2.50109394
89cholesterol homeostasis (GO:0042632)2.48015374
90cellular glucuronidation (GO:0052695)2.47077612
91regulation of vitamin metabolic process (GO:0030656)2.47063997
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.46143594
93ceramide catabolic process (GO:0046514)2.45987017
94plasma lipoprotein particle clearance (GO:0034381)2.44672627
95negative regulation of cytokine production involved in immune response (GO:0002719)2.44549912
96regulation of interferon-beta biosynthetic process (GO:0045357)2.43503854
97sterol homeostasis (GO:0055092)2.43005021
98urea metabolic process (GO:0019627)2.42940760
99drug metabolic process (GO:0017144)2.40930026
100low-density lipoprotein particle clearance (GO:0034383)2.39739511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.94763577
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.84575599
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.75170767
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.43210081
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.05527789
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.76806365
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.47463908
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.44876543
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25557793
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.23766321
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18623285
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15724038
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13041192
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.05193451
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02501720
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94514660
17LXR_22292898_ChIP-Seq_THP-1_Human1.93645836
18EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88018142
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87219775
20SPI1_23547873_ChIP-Seq_NB4_Human1.86827260
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86682554
22VDR_21846776_ChIP-Seq_THP-1_Human1.85795743
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83679383
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.80276186
25VDR_24763502_ChIP-Seq_THP-1_Human1.79919636
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75878238
27BCL6_27268052_Chip-Seq_Bcells_Human1.73760753
28CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73731163
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72971592
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66454618
31BCOR_27268052_Chip-Seq_Bcells_Human1.63523279
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63460607
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63411036
34CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61579031
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57873867
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57084301
37SPI1_23127762_ChIP-Seq_K562_Human1.56714147
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.51394220
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.49103395
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47088838
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46098037
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45653172
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44974124
44PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44610967
45GATA4_25053715_ChIP-Seq_YYC3_Human1.43800384
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40809365
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40431929
48CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36190094
49MAF_26560356_Chip-Seq_TH1_Human1.35178346
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34294260
51GATA6_25053715_ChIP-Seq_YYC3_Human1.34169136
52UTX_26944678_Chip-Seq_JUKART_Human1.33206095
53RUNX_20019798_ChIP-Seq_JUKART_Human1.32829104
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31815087
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30296341
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30056632
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29235560
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28464199
59E2F1_20622854_ChIP-Seq_HELA_Human1.28378922
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27455716
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24724229
62GATA1_22025678_ChIP-Seq_K562_Human1.24076280
63SA1_27219007_Chip-Seq_Bcells_Human1.22155473
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.20716812
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20242903
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20113390
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17943851
68GATA1_19941826_ChIP-Seq_K562_Human1.17905172
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17652504
70MYB_26560356_Chip-Seq_TH1_Human1.17514284
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17475989
72MYB_26560356_Chip-Seq_TH2_Human1.16974424
73P68_20966046_ChIP-Seq_HELA_Human1.16899358
74PHF8_20622854_ChIP-Seq_HELA_Human1.16376117
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.16169823
76P300_27268052_Chip-Seq_Bcells_Human1.15607240
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14720646
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14437708
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14386963
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.13446500
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13087863
82STAT1_20625510_ChIP-Seq_HELA_Human1.12779728
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11022196
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10040042
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09147307
86NANOG_20526341_ChIP-Seq_ESCs_Human1.09013164
87RACK7_27058665_Chip-Seq_MCF-7_Human1.08323095
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05270519
89SCL_19346495_ChIP-Seq_HPC-7_Human1.03699629
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03112138
91MAF_26560356_Chip-Seq_TH2_Human1.03056966
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.02705876
93HNF4A_19822575_ChIP-Seq_HepG2_Human1.01848881
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.00887028
95SOX2_20726797_ChIP-Seq_SW620_Human0.99795721
96MYC_22102868_ChIP-Seq_BL_Human0.98984786
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98850169
98VDR_24787735_ChIP-Seq_THP-1_Human0.98497962
99RAC3_21632823_ChIP-Seq_H3396_Human0.98447437
100SPI1_20517297_ChIP-Seq_HL60_Human0.96825443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.36472545
2MP0002139_abnormal_hepatobiliary_system3.77811331
3MP0005365_abnormal_bile_salt3.57159890
4MP0005085_abnormal_gallbladder_physiolo3.22118819
5MP0003724_increased_susceptibility_to3.15853434
6MP0009840_abnormal_foam_cell3.12379097
7MP0003806_abnormal_nucleotide_metabolis3.09625529
8MP0003183_abnormal_peptide_metabolism3.03596813
9MP0001666_abnormal_nutrient_absorption2.89240036
10MP0003436_decreased_susceptibility_to2.70202537
11MP0010155_abnormal_intestine_physiology2.39641395
12MP0001835_abnormal_antigen_presentation2.37489354
13MP0003303_peritoneal_inflammation2.27059491
14MP0009785_altered_susceptibility_to2.19917262
15MP0010329_abnormal_lipoprotein_level2.14408305
16MP0004019_abnormal_vitamin_homeostasis2.13477191
17MP0004264_abnormal_extraembryonic_tissu2.06557021
18MP0005058_abnormal_lysosome_morphology2.05917661
19MP0005025_abnormal_response_to2.04576819
20MP0003191_abnormal_cellular_cholesterol2.01441523
21MP0003866_abnormal_defecation2.01394991
22MP0002419_abnormal_innate_immunity1.89082925
23MP0006082_CNS_inflammation1.87517154
24MP0001800_abnormal_humoral_immune1.84245599
25MP0005671_abnormal_response_to1.83736886
26MP0002148_abnormal_hypersensitivity_rea1.83018714
27MP0001790_abnormal_immune_system1.80878949
28MP0005387_immune_system_phenotype1.80878949
29MP0000685_abnormal_immune_system1.79337122
30MP0005000_abnormal_immune_tolerance1.77477046
31MP0004147_increased_porphyrin_level1.71420249
32MP0005451_abnormal_body_composition1.68873937
33MP0005464_abnormal_platelet_physiology1.68373528
34MP0009764_decreased_sensitivity_to1.64432321
35MP0002723_abnormal_immune_serum1.61666044
36MP0002132_abnormal_respiratory_system1.59852431
37MP0002452_abnormal_antigen_presenting1.56017762
38MP0003172_abnormal_lysosome_physiology1.55273246
39MP0001533_abnormal_skeleton_physiology1.54418091
40MP0008469_abnormal_protein_level1.54275019
41MP0001845_abnormal_inflammatory_respons1.54013030
42MP0001819_abnormal_immune_cell1.46566744
43MP0002420_abnormal_adaptive_immunity1.46142731
44MP0001873_stomach_inflammation1.44999470
45MP0009643_abnormal_urine_homeostasis1.40433443
46MP0003252_abnormal_bile_duct1.40123029
47MP0009333_abnormal_splenocyte_physiolog1.36799269
48MP0005166_decreased_susceptibility_to1.34886557
49MP0000609_abnormal_liver_physiology1.33936609
50MP0001663_abnormal_digestive_system1.31208890
51MP0002138_abnormal_hepatobiliary_system1.30818629
52MP0002118_abnormal_lipid_homeostasis1.24032650
53MP0005332_abnormal_amino_acid1.23595997
54MP0009379_abnormal_foot_pigmentation1.23271891
55MP0008875_abnormal_xenobiotic_pharmacok1.21055742
56MP0005319_abnormal_enzyme/_coenzyme1.20457716
57MP0003300_gastrointestinal_ulcer1.18444094
58MP0001764_abnormal_homeostasis1.18103494
59MP0008260_abnormal_autophagy1.17921131
60MP0000490_abnormal_crypts_of1.16128875
61MP0000465_gastrointestinal_hemorrhage1.15983235
62MP0005636_abnormal_mineral_homeostasis1.14803823
63MP0004947_skin_inflammation1.12320116
64MP0000858_altered_metastatic_potential1.08319306
65MP0005084_abnormal_gallbladder_morpholo1.08008481
66MP0000716_abnormal_immune_system1.05347892
67MP0001664_abnormal_digestion1.04174670
68MP0002405_respiratory_system_inflammati1.03053734
69MP0001765_abnormal_ion_homeostasis1.00309603
70MP0002136_abnormal_kidney_physiology0.96649609
71MP0005670_abnormal_white_adipose0.94417058
72MP0003075_altered_response_to0.90855534
73MP0005584_abnormal_enzyme/coenzyme_acti0.90643386
74MP0002398_abnormal_bone_marrow0.90389795
75MP0008004_abnormal_stomach_pH0.90216304
76MP0000604_amyloidosis0.89295621
77MP0002429_abnormal_blood_cell0.88618897
78MP0003868_abnormal_feces_composition0.88376695
79MP0005381_digestive/alimentary_phenotyp0.87586497
80MP0000477_abnormal_intestine_morphology0.87336818
81MP0003763_abnormal_thymus_physiology0.87252606
82MP0001756_abnormal_urination0.87129550
83MP0003879_abnormal_hair_cell0.86359337
84MP0000689_abnormal_spleen_morphology0.85599137
85MP0005410_abnormal_fertilization0.83645626
86MP0009642_abnormal_blood_homeostasis0.81393605
87MP0009115_abnormal_fat_cell0.81270672
88MP0005409_darkened_coat_color0.81267534
89MP0003011_delayed_dark_adaptation0.79822256
90MP0002876_abnormal_thyroid_physiology0.79696906
91MP0002722_abnormal_immune_system0.78722521
92MP0002166_altered_tumor_susceptibility0.78477252
93MP0002396_abnormal_hematopoietic_system0.77143563
94MP0005448_abnormal_energy_balance0.76487928
95MP0002998_abnormal_bone_remodeling0.74835041
96MP0005535_abnormal_body_temperature0.74102767
97MP0001986_abnormal_taste_sensitivity0.73431367
98MP0000343_altered_response_to0.73012705
99MP0005310_abnormal_salivary_gland0.72422346
100MP0003195_calcinosis0.72035904

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)4.99348246
2Systemic lupus erythematosus (HP:0002725)4.42860940
3Malnutrition (HP:0004395)4.14216890
4Eczematoid dermatitis (HP:0000976)4.04968190
5Hypobetalipoproteinemia (HP:0003563)3.91740634
6Abnormality of macrophages (HP:0004311)3.56559155
7Myositis (HP:0100614)3.50292994
8Recurrent abscess formation (HP:0002722)3.44115242
9Hydroxyprolinuria (HP:0003080)3.43196304
10Abnormality of proline metabolism (HP:0010907)3.43196304
11Elevated erythrocyte sedimentation rate (HP:0003565)3.40049557
12Recurrent bacterial skin infections (HP:0005406)3.37077669
13Hemorrhage of the eye (HP:0011885)3.28847388
14Amyloidosis (HP:0011034)3.27557437
15Orchitis (HP:0100796)3.22734711
16Chronic diarrhea (HP:0002028)3.15633416
17Xanthomatosis (HP:0000991)3.13296429
18Acanthocytosis (HP:0001927)3.11009278
19Glomerulonephritis (HP:0000099)3.06695583
20Widely patent fontanelles and sutures (HP:0004492)3.02416940
21Gastrointestinal infarctions (HP:0005244)2.99285294
22Petechiae (HP:0000967)2.95269920
23Recurrent gram-negative bacterial infections (HP:0005420)2.92473452
24Nausea (HP:0002018)2.84956773
25Optic neuritis (HP:0100653)2.80892807
26Retrobulbar optic neuritis (HP:0100654)2.80892807
27Ileus (HP:0002595)2.78233928
28Stomatitis (HP:0010280)2.73543015
29Chronic obstructive pulmonary disease (HP:0006510)2.70744226
30Obstructive lung disease (HP:0006536)2.70744226
31Fat malabsorption (HP:0002630)2.70131299
32Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68638426
33Pigmentary retinal degeneration (HP:0001146)2.67030885
34Deep venous thrombosis (HP:0002625)2.65982601
35Vasculitis (HP:0002633)2.59438904
36Complement deficiency (HP:0004431)2.54091199
37Vacuolated lymphocytes (HP:0001922)2.51544661
38Encephalitis (HP:0002383)2.50889282
39Pustule (HP:0200039)2.48374106
40Abnormality of complement system (HP:0005339)2.46657225
41Abnormality of the vitamin B12 metabolism (HP:0004341)2.46067294
42Purpura (HP:0000979)2.42282816
43Abnormality of liposaccharide metabolism (HP:0010968)2.40770946
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.40770946
45Abnormality of glycolipid metabolism (HP:0010969)2.40770946
46Dysostosis multiplex (HP:0000943)2.33581046
47Gingival bleeding (HP:0000225)2.33311278
48Increased serum ferritin (HP:0003281)2.31984594
49Alkalosis (HP:0001948)2.30262989
50Recurrent skin infections (HP:0001581)2.29608386
51Prolonged bleeding time (HP:0003010)2.28775595
52Recurrent fungal infections (HP:0002841)2.27384631
53Decreased circulating renin level (HP:0003351)2.26368698
54Abnormality of vitamin B metabolism (HP:0004340)2.25676545
55Meningitis (HP:0001287)2.23939441
56Hypochromic anemia (HP:0001931)2.22625343
57Abnormality of iron homeostasis (HP:0011031)2.21307170
58Urticaria (HP:0001025)2.20712096
59Hypolipoproteinemia (HP:0010981)2.20388446
60Episodic fever (HP:0001954)2.20266821
61Increased cerebral lipofuscin (HP:0011813)2.20183575
62Hyperammonemia (HP:0001987)2.19071053
63Hypophosphatemia (HP:0002148)2.17816673
64Gingivitis (HP:0000230)2.17476733
65Abnormality of pyrimidine metabolism (HP:0004353)2.16617307
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.15399697
67Joint hemorrhage (HP:0005261)2.12598875
68Abnormality of transition element cation homeostasis (HP:0011030)2.11185941
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.09185886
70Urinary glycosaminoglycan excretion (HP:0003541)2.08650373
71Mucopolysacchariduria (HP:0008155)2.08650373
72Abnormality of urine glucose concentration (HP:0011016)2.08604068
73Glycosuria (HP:0003076)2.08604068
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08205280
75Abnormality of polysaccharide metabolism (HP:0011012)2.08205280
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08205280
77Metabolic alkalosis (HP:0200114)2.06978198
78Mediastinal lymphadenopathy (HP:0100721)2.04588742
79Abdominal distention (HP:0003270)2.00153979
80Hyperactive renin-angiotensin system (HP:0000841)2.00042891
81Hemoptysis (HP:0002105)1.96184950
82Skin rash (HP:0000988)1.95893812
83Epistaxis (HP:0000421)1.95759637
84Pulmonary infiltrates (HP:0002113)1.95203412
85Wide cranial sutures (HP:0010537)1.94215345
86Keratoconjunctivitis sicca (HP:0001097)1.93664850
87Inflammation of the large intestine (HP:0002037)1.92002547
88Anorexia (HP:0002039)1.91986338
89Thin bony cortex (HP:0002753)1.91687735
90Keratoconjunctivitis (HP:0001096)1.90367741
91Abnormality of vitamin metabolism (HP:0100508)1.88515815
92Nephritis (HP:0000123)1.86292339
93Posterior subcapsular cataract (HP:0007787)1.85526434
94Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.84757656
95Growth hormone excess (HP:0000845)1.84282799
96Pancreatitis (HP:0001733)1.83890098
97Hyperglycinuria (HP:0003108)1.83853998
98Pulmonary embolism (HP:0002204)1.83390901
99Gastrointestinal inflammation (HP:0004386)1.83118187
100Prolonged partial thromboplastin time (HP:0003645)1.82421297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.02638985
2RIPK43.74941416
3ACVR1B3.17900860
4INSRR3.07954659
5MAP4K12.96749543
6TXK2.85199465
7TYK22.71474183
8GRK62.54172812
9BLK2.14819579
10IRAK42.12133367
11CSK2.08486959
12MAP2K31.98553829
13FES1.91871115
14KDR1.89368375
15PRKG21.88278761
16ZAP701.86511662
17MST1R1.85397769
18MATK1.76419002
19FGFR41.72595149
20TESK21.72026407
21TGFBR21.62587651
22TBK11.60778892
23SYK1.54289078
24MAP2K21.48959770
25BTK1.47424638
26MAP3K141.44155525
27LYN1.41818030
28MAP3K111.40204608
29PDK21.37989357
30MAP3K31.37074846
31MAP3K11.34742981
32PDPK11.34335026
33FGR1.33566692
34CSF1R1.26735231
35PDK11.23094676
36PRPF4B1.21832330
37JAK31.16526248
38TAOK31.09251250
39IKBKE1.08905972
40MARK31.08206730
41NME21.07746829
42IRAK31.06380227
43RIPK11.06354171
44TNK21.03874846
45ITK1.02606084
46IKBKB1.02135005
47LCK1.01380031
48JAK20.97742320
49MAP3K20.95558159
50MAPK110.94619379
51PTK60.93536897
52HCK0.91452336
53KIT0.88221235
54SIK30.86112952
55TEC0.84954377
56OXSR10.83107913
57BMPR20.81621497
58FGFR30.81176216
59MAP2K60.79603130
60CDC42BPA0.78967193
61SIK20.77247899
62MAP3K120.75190394
63TAOK10.74606243
64TRIB30.74559945
65KSR20.73203273
66PIK3CA0.73055421
67WNK40.70882064
68JAK10.70741239
69STK390.66798894
70NME10.66589950
71DYRK1B0.62698008
72PRKAA20.58792746
73EPHA20.58737935
74PRKCQ0.56808513
75EPHB10.56026456
76PINK10.54146788
77FYN0.53279589
78YES10.51799653
79TAOK20.50284600
80LRRK20.49811604
81STK100.48401463
82SMG10.48250366
83GRK70.47479658
84BMX0.47081015
85TLK10.43988701
86PIM20.43738562
87IGF1R0.40457381
88PIM10.38625569
89TESK10.38058503
90PRKACG0.37760322
91ABL20.37736063
92PRKCD0.37377822
93CDK190.37063259
94DAPK10.37010404
95GRK10.34160379
96MUSK0.33973217
97SRC0.33510544
98MAPKAPK20.33506561
99SIK10.33136953
100DDR20.33000731

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.50069029
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.45668315
3Vitamin digestion and absorption_Homo sapiens_hsa049773.38492854
4Staphylococcus aureus infection_Homo sapiens_hsa051502.81529550
5Renin-angiotensin system_Homo sapiens_hsa046142.42577035
6Asthma_Homo sapiens_hsa053102.35240480
7Other glycan degradation_Homo sapiens_hsa005112.22249340
8Allograft rejection_Homo sapiens_hsa053302.21453165
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.16453840
10Graft-versus-host disease_Homo sapiens_hsa053322.06669814
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.04280703
12Autoimmune thyroid disease_Homo sapiens_hsa053201.98045024
13Leishmaniasis_Homo sapiens_hsa051401.89750723
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85331438
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.82781900
16Mineral absorption_Homo sapiens_hsa049781.79526208
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78957460
18PPAR signaling pathway_Homo sapiens_hsa033201.78072252
19Sulfur metabolism_Homo sapiens_hsa009201.77550547
20Starch and sucrose metabolism_Homo sapiens_hsa005001.76571216
21Fructose and mannose metabolism_Homo sapiens_hsa000511.69158779
22Histidine metabolism_Homo sapiens_hsa003401.65029764
23Arginine biosynthesis_Homo sapiens_hsa002201.64384151
24Galactose metabolism_Homo sapiens_hsa000521.60912168
25Type I diabetes mellitus_Homo sapiens_hsa049401.60580618
26* Chemical carcinogenesis_Homo sapiens_hsa052041.55527719
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.51575775
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.33829354
29Antigen processing and presentation_Homo sapiens_hsa046121.32566508
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32013299
31Retinol metabolism_Homo sapiens_hsa008301.31113295
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29737508
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27355712
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25526456
35Caffeine metabolism_Homo sapiens_hsa002321.25125002
36Complement and coagulation cascades_Homo sapiens_hsa046101.24721317
37Fatty acid degradation_Homo sapiens_hsa000711.23564253
38Osteoclast differentiation_Homo sapiens_hsa043801.21107261
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19810915
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17954821
41Glycerolipid metabolism_Homo sapiens_hsa005611.15695710
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.14335802
43Hematopoietic cell lineage_Homo sapiens_hsa046401.13039676
44Arachidonic acid metabolism_Homo sapiens_hsa005901.09701881
45Tuberculosis_Homo sapiens_hsa051521.08320058
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07852398
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.07427834
48Linoleic acid metabolism_Homo sapiens_hsa005911.05508080
49Pertussis_Homo sapiens_hsa051330.98537977
50Bile secretion_Homo sapiens_hsa049760.97710661
51Primary immunodeficiency_Homo sapiens_hsa053400.97526047
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91205966
53Tryptophan metabolism_Homo sapiens_hsa003800.87900244
54Viral myocarditis_Homo sapiens_hsa054160.87805553
55Rheumatoid arthritis_Homo sapiens_hsa053230.86673125
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80540120
57Phenylalanine metabolism_Homo sapiens_hsa003600.80064894
58Protein digestion and absorption_Homo sapiens_hsa049740.79113305
59African trypanosomiasis_Homo sapiens_hsa051430.77426801
60Arginine and proline metabolism_Homo sapiens_hsa003300.77188042
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.76627272
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.74519180
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73880938
64Lysosome_Homo sapiens_hsa041420.73413885
65Toxoplasmosis_Homo sapiens_hsa051450.72740340
66Peroxisome_Homo sapiens_hsa041460.70309278
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69730584
68Influenza A_Homo sapiens_hsa051640.68711285
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64674882
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64267079
71B cell receptor signaling pathway_Homo sapiens_hsa046620.62724650
72Fatty acid metabolism_Homo sapiens_hsa012120.62179164
73Glutathione metabolism_Homo sapiens_hsa004800.59996690
74Phagosome_Homo sapiens_hsa041450.59363351
75Herpes simplex infection_Homo sapiens_hsa051680.59242812
76Sulfur relay system_Homo sapiens_hsa041220.57789624
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.53194721
78Ether lipid metabolism_Homo sapiens_hsa005650.52387704
79Chemokine signaling pathway_Homo sapiens_hsa040620.51136937
80Sphingolipid metabolism_Homo sapiens_hsa006000.50406691
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49180035
82Legionellosis_Homo sapiens_hsa051340.48440318
83Malaria_Homo sapiens_hsa051440.43744478
84Nitrogen metabolism_Homo sapiens_hsa009100.43744055
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42987811
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42930009
87TNF signaling pathway_Homo sapiens_hsa046680.40649042
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40319077
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39226755
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39141251
91Fatty acid elongation_Homo sapiens_hsa000620.39050493
92Fatty acid biosynthesis_Homo sapiens_hsa000610.39018677
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38192339
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37913848
95Pentose phosphate pathway_Homo sapiens_hsa000300.37202229
96Hepatitis C_Homo sapiens_hsa051600.37070179
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.36967197
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.35796625
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35603691
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35128717

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