SULT1B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.97859049
2intestinal cholesterol absorption (GO:0030299)6.82214346
3intestinal absorption (GO:0050892)6.62039395
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.89618192
5L-phenylalanine catabolic process (GO:0006559)5.89618192
6regulation of cholesterol esterification (GO:0010872)5.73857475
7L-phenylalanine metabolic process (GO:0006558)5.73439322
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.73439322
9regulation of triglyceride catabolic process (GO:0010896)5.71152267
10phospholipid efflux (GO:0033700)5.58433153
11high-density lipoprotein particle remodeling (GO:0034375)5.55386164
12urea cycle (GO:0000050)5.39458188
13urea metabolic process (GO:0019627)5.39458188
14aromatic amino acid family catabolic process (GO:0009074)5.34699522
15drug catabolic process (GO:0042737)5.14962756
16reverse cholesterol transport (GO:0043691)5.12838201
17negative regulation of sterol transport (GO:0032372)4.98674627
18negative regulation of cholesterol transport (GO:0032375)4.98674627
19plasma lipoprotein particle assembly (GO:0034377)4.92353145
20nitrogen cycle metabolic process (GO:0071941)4.92271990
21positive regulation of lipoprotein lipase activity (GO:0051006)4.91109301
22positive regulation of triglyceride lipase activity (GO:0061365)4.91109301
23cholesterol efflux (GO:0033344)4.90796260
24tryptophan catabolic process (GO:0006569)4.89697537
25indole-containing compound catabolic process (GO:0042436)4.89697537
26indolalkylamine catabolic process (GO:0046218)4.89697537
27protein-lipid complex remodeling (GO:0034368)4.83178456
28macromolecular complex remodeling (GO:0034367)4.83178456
29plasma lipoprotein particle remodeling (GO:0034369)4.83178456
30sulfur amino acid catabolic process (GO:0000098)4.82566272
31kynurenine metabolic process (GO:0070189)4.77688445
32regulation of bile acid biosynthetic process (GO:0070857)4.76857254
33cysteine metabolic process (GO:0006534)4.75424448
34bile acid biosynthetic process (GO:0006699)4.72521027
35bile acid and bile salt transport (GO:0015721)4.72455951
36cellular glucuronidation (GO:0052695)4.67699318
37homocysteine metabolic process (GO:0050667)4.66416022
38regulation of pigment cell differentiation (GO:0050932)4.62182637
39tryptophan metabolic process (GO:0006568)4.59405550
40alpha-linolenic acid metabolic process (GO:0036109)4.59391232
41very-low-density lipoprotein particle assembly (GO:0034379)4.57295487
42glyoxylate metabolic process (GO:0046487)4.52419626
43protein-lipid complex assembly (GO:0065005)4.49905738
44bile acid metabolic process (GO:0008206)4.44400366
45triglyceride homeostasis (GO:0070328)4.40954959
46acylglycerol homeostasis (GO:0055090)4.40954959
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36155118
48angiotensin maturation (GO:0002003)4.34243195
49cholesterol homeostasis (GO:0042632)4.32228872
50lipoprotein metabolic process (GO:0042157)4.27510407
51sterol homeostasis (GO:0055092)4.25934404
52lipid translocation (GO:0034204)4.21605910
53phospholipid translocation (GO:0045332)4.21605910
54glucuronate metabolic process (GO:0019585)4.21492678
55uronic acid metabolic process (GO:0006063)4.21492678
56amino-acid betaine metabolic process (GO:0006577)4.06898825
57negative regulation of fibrinolysis (GO:0051918)4.02534875
58regulation of cholesterol homeostasis (GO:2000188)4.02397249
59plasma lipoprotein particle clearance (GO:0034381)4.02067676
60lysine metabolic process (GO:0006553)4.00504318
61lysine catabolic process (GO:0006554)4.00504318
62establishment of protein localization to Golgi (GO:0072600)3.98759970
63positive regulation of lipid catabolic process (GO:0050996)3.98044922
64peptidyl-glutamic acid carboxylation (GO:0017187)3.96977744
65protein carboxylation (GO:0018214)3.96977744
66complement activation, alternative pathway (GO:0006957)3.96136485
67regulation of establishment of cell polarity (GO:2000114)3.94338736
68plasma lipoprotein particle organization (GO:0071827)3.93208591
69regulation of protein activation cascade (GO:2000257)3.92853821
70serine family amino acid catabolic process (GO:0009071)3.92011480
71regulation of fibrinolysis (GO:0051917)3.90881703
72exogenous drug catabolic process (GO:0042738)3.88864318
73aromatic amino acid family metabolic process (GO:0009072)3.87694988
74protein K11-linked deubiquitination (GO:0035871)3.86222504
75phospholipid homeostasis (GO:0055091)3.83491029
76cellular ketone body metabolic process (GO:0046950)3.79779975
77positive regulation of developmental pigmentation (GO:0048087)3.78633978
78protein K48-linked deubiquitination (GO:0071108)3.76508601
79drug metabolic process (GO:0017144)3.76402958
80protein-lipid complex subunit organization (GO:0071825)3.74958133
81sterol transport (GO:0015918)3.68687611
82cholesterol transport (GO:0030301)3.68687611
83regulation of complement activation (GO:0030449)3.67485879
84response to nitrosative stress (GO:0051409)3.67333800
85positive regulation of fatty acid biosynthetic process (GO:0045723)3.65494284
86* flavonoid metabolic process (GO:0009812)3.64997234
87neural tube formation (GO:0001841)3.64996741
88benzene-containing compound metabolic process (GO:0042537)3.62700250
89interkinetic nuclear migration (GO:0022027)3.62495823
90drug transmembrane transport (GO:0006855)3.61722265
91alpha-amino acid catabolic process (GO:1901606)3.61201424
92positive regulation of triglyceride metabolic process (GO:0090208)3.60832912
93tyrosine metabolic process (GO:0006570)3.58849193
94arginine metabolic process (GO:0006525)3.58539032
95glutamate metabolic process (GO:0006536)3.56990248
96L-fucose catabolic process (GO:0042355)3.53549242
97fucose catabolic process (GO:0019317)3.53549242
98L-fucose metabolic process (GO:0042354)3.53549242
99epoxygenase P450 pathway (GO:0019373)3.52425074
100regulation of establishment or maintenance of cell polarity (GO:0032878)3.51976435
101ethanol oxidation (GO:0006069)3.50019385
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.47913346
103indolalkylamine metabolic process (GO:0006586)3.45184831
104monoubiquitinated protein deubiquitination (GO:0035520)3.43639721
105hormone catabolic process (GO:0042447)3.43515204
106low-density lipoprotein particle remodeling (GO:0034374)3.43156168
107cellular amino acid catabolic process (GO:0009063)3.41400001
108cellular modified amino acid catabolic process (GO:0042219)3.38717728
109coenzyme catabolic process (GO:0009109)3.37622360
110xenobiotic catabolic process (GO:0042178)3.37618581
111lipid homeostasis (GO:0055088)3.37500962
112amine catabolic process (GO:0009310)3.34956550
113cellular biogenic amine catabolic process (GO:0042402)3.34956550
114negative regulation of lipase activity (GO:0060192)3.32770693
115drug transport (GO:0015893)3.31840827
116alkaloid metabolic process (GO:0009820)3.29893838
117signal peptide processing (GO:0006465)3.27563524
118cellular response to ethanol (GO:0071361)3.25282407
119negative regulation of sodium ion transport (GO:0010766)3.22604971
120oxidative demethylation (GO:0070989)3.21309311
121snRNA transcription (GO:0009301)3.15008815
122protein targeting to vacuole (GO:0006623)3.10705330
123protein targeting to lysosome (GO:0006622)3.10705330
124establishment of protein localization to vacuole (GO:0072666)3.10705330
125NAD biosynthetic process (GO:0009435)3.08849232
126negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.07113953
127negative regulation of translation, ncRNA-mediated (GO:0040033)3.07113953
128regulation of translation, ncRNA-mediated (GO:0045974)3.07113953
129protein K63-linked deubiquitination (GO:0070536)3.05563450
130striated muscle atrophy (GO:0014891)3.04047553
131behavioral response to nicotine (GO:0035095)2.94463731
132cilium or flagellum-dependent cell motility (GO:0001539)2.92420246
133regulation of hippo signaling (GO:0035330)2.90700165
134killing of cells of other organism (GO:0031640)2.88563682
135disruption of cells of other organism (GO:0044364)2.88563682
136endosome to melanosome transport (GO:0035646)2.85899081
137endosome to pigment granule transport (GO:0043485)2.85899081
138negative regulation of protein localization to cell surface (GO:2000009)2.84746778
139cytoplasmic mRNA processing body assembly (GO:0033962)2.84656414
140regulation of guanylate cyclase activity (GO:0031282)2.84052901
141sulfate transmembrane transport (GO:1902358)2.82151408
142regulation of B cell receptor signaling pathway (GO:0050855)2.80162748
143serotonin metabolic process (GO:0042428)2.76138298
144indole-containing compound metabolic process (GO:0042430)2.74704355
145regulation of interleukin-12 biosynthetic process (GO:0045075)2.74434141
146skeletal muscle adaptation (GO:0043501)2.71950220
147proline transport (GO:0015824)2.69250796
148regulation of membrane lipid distribution (GO:0097035)2.69237295
149cardiovascular system development (GO:0072358)2.68358958
150positive regulation of fatty acid beta-oxidation (GO:0032000)2.67429524
151regulation of developmental pigmentation (GO:0048070)2.65282057
152primary amino compound metabolic process (GO:1901160)2.62356125
153detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61678214
154activated T cell proliferation (GO:0050798)2.58288847
155phosphatidylinositol acyl-chain remodeling (GO:0036149)2.58093025
156detection of light stimulus involved in visual perception (GO:0050908)2.57448922
157detection of light stimulus involved in sensory perception (GO:0050962)2.57448922
158regulation of sarcomere organization (GO:0060297)2.56802501
159positive regulation of fatty acid oxidation (GO:0046321)2.56031316
160phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.55712722
161protein targeting to Golgi (GO:0000042)2.55510351
162UDP-N-acetylglucosamine metabolic process (GO:0006047)2.54288756
163reflex (GO:0060004)2.53927580
164negative regulation of systemic arterial blood pressure (GO:0003085)2.53506791
165defense response to fungus (GO:0050832)2.49015300
166negative regulation of mast cell activation (GO:0033004)2.47481517
167retrograde transport, vesicle recycling within Golgi (GO:0000301)2.44384725
168nicotinamide nucleotide biosynthetic process (GO:0019359)2.43301826
169pyridine nucleotide biosynthetic process (GO:0019363)2.43301826
170macroautophagy (GO:0016236)2.42258120
171regulation of gene silencing by RNA (GO:0060966)2.41514126
172regulation of posttranscriptional gene silencing (GO:0060147)2.41514126
173regulation of gene silencing by miRNA (GO:0060964)2.41514126
174endocardial cushion development (GO:0003197)2.40514889
175positive regulation of guanylate cyclase activity (GO:0031284)2.38480071
176pericardium development (GO:0060039)2.38006776
177sulfate transport (GO:0008272)2.36015182
178synaptic vesicle docking involved in exocytosis (GO:0016081)2.35531974
179photoreceptor cell maintenance (GO:0045494)2.34831405
180negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.33375334
181rRNA catabolic process (GO:0016075)2.31794029
182muscle atrophy (GO:0014889)2.31577817
183gamma-aminobutyric acid transport (GO:0015812)2.30296349
184kidney morphogenesis (GO:0060993)2.27212166
185neuronal action potential (GO:0019228)2.26406871
186regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.26171932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.20300352
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.46941871
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.01847659
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.87481408
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.39696610
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.21426740
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.15395668
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.58152968
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.52681809
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.00960645
11GBX2_23144817_ChIP-Seq_PC3_Human2.81069021
12* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.80623416
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.68540111
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62694264
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.38208665
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31119984
17VDR_22108803_ChIP-Seq_LS180_Human2.31042636
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27221087
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15474473
20EZH2_22144423_ChIP-Seq_EOC_Human2.14873794
21* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06805779
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04749311
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03852015
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.03092992
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1437111
26ZNF274_21170338_ChIP-Seq_K562_Hela1.99590688
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97190201
28GATA4_25053715_ChIP-Seq_YYC3_Human1.96563902
29TAF15_26573619_Chip-Seq_HEK293_Human1.91190809
30TP53_16413492_ChIP-PET_HCT116_Human1.83011732
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77493905
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77341823
33ER_23166858_ChIP-Seq_MCF-7_Human1.76218681
34* STAT3_23295773_ChIP-Seq_U87_Human1.74419758
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73043121
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.73036158
37* PIAS1_25552417_ChIP-Seq_VCAP_Human1.72821606
38DROSHA_22980978_ChIP-Seq_HELA_Human1.69451980
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68704337
40P300_19829295_ChIP-Seq_ESCs_Human1.68697239
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.62382376
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.59505813
43SMAD4_21799915_ChIP-Seq_A2780_Human1.59407803
44IGF1R_20145208_ChIP-Seq_DFB_Human1.57974306
45* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55643580
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53684019
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53335311
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52947943
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52628279
50TCF4_23295773_ChIP-Seq_U87_Human1.51112589
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47963385
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47425815
53CLOCK_20551151_ChIP-Seq_293T_Human1.46812032
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45474308
55SOX2_20726797_ChIP-Seq_SW620_Human1.42348391
56GATA6_25053715_ChIP-Seq_YYC3_Human1.41775531
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.39217236
58AR_25329375_ChIP-Seq_VCAP_Human1.39206598
59AR_21572438_ChIP-Seq_LNCaP_Human1.38801007
60AHR_22903824_ChIP-Seq_MCF-7_Human1.38295650
61EWS_26573619_Chip-Seq_HEK293_Human1.36017939
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35208518
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.34975312
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33421412
65HTT_18923047_ChIP-ChIP_STHdh_Human1.32981128
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32477641
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32016253
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32016253
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.31970916
70FUS_26573619_Chip-Seq_HEK293_Human1.31691294
71GATA1_22025678_ChIP-Seq_K562_Human1.30858551
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30321403
73CBP_20019798_ChIP-Seq_JUKART_Human1.28068985
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28068985
75RXR_22108803_ChIP-Seq_LS180_Human1.25192118
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23858187
77TCF4_22108803_ChIP-Seq_LS180_Human1.23791473
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22755805
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22613961
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.22391200
81RUNX2_22187159_ChIP-Seq_PCA_Human1.19281340
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18062516
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.17774076
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17560760
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.16480500
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16459596
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.14795567
88VDR_24787735_ChIP-Seq_THP-1_Human1.13047460
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.11735614
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11697341
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11322654
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10859574
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.09519458
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09273658
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08585447
96* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08063230
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07884695
98CJUN_26792858_Chip-Seq_BT549_Human1.06349900
99* KDM2B_26808549_Chip-Seq_REH_Human1.06060438
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05936948
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.04119664
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03953775
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.03093703
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.02311925
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02191238
106OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01756911
107* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01711860
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00946602
109RUNX_20019798_ChIP-Seq_JUKART_Human1.00737571
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00331723
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00302645
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.99598675
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97736702
114* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97406602
115CRX_20693478_ChIP-Seq_RETINA_Mouse0.97361336
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.96971036
117P53_22387025_ChIP-Seq_ESCs_Mouse0.96820710
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95312317
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94848970
120KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93882603
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93251160
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.92566554
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91721115
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.89183211
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88553693
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.88154958
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87139359
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87012363
129EGR1_19032775_ChIP-ChIP_M12_Human0.86868171
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86857048
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86336882
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83564305
133RARA_24833708_ChIP-Seq_LIVER_Mouse0.78330049
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.78011870
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77965818
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77739427
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.76402998
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76277315
139GATA2_19941826_ChIP-Seq_K562_Human0.75419149
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75099588
141ZNF263_19887448_ChIP-Seq_K562_Human0.73260502
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72479016
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.72081984
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71681575
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70467227
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68419830
147ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68157632
148BCAT_22108803_ChIP-Seq_LS180_Human0.68140904
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67795962
150NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67795962
151SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67143693
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.65649146
153TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.64780393
154CEBPB_22108803_ChIP-Seq_LS180_Human0.64564766
155STAT1_17558387_ChIP-Seq_HELA_Human0.64559831
156RACK7_27058665_Chip-Seq_MCF-7_Human0.63594859
157ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.63305662
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63285229
159AUTS2_25519132_ChIP-Seq_293T-REX_Human0.62363080
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.61137443
161CDX2_22108803_ChIP-Seq_LS180_Human0.60832726
162AR_20517297_ChIP-Seq_VCAP_Human0.59682920
163KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.59669871
164MYC_19915707_ChIP-ChIP_AK7_Human0.59651565
165ZNF217_24962896_ChIP-Seq_MCF-7_Human0.59086462
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.58908814
167CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.57687517
168RUNX1_27514584_Chip-Seq_MCF-7_Human0.57677942
169TCF4_18268006_ChIP-ChIP_LS174T_Human0.57260530
170FOXM1_26456572_ChIP-Seq_MCF-7_Human0.56908282
171KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.56666521
172MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.56568654
173FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56451560
174LXR_22292898_ChIP-Seq_THP-1_Human0.53638112
175NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.52708972
176CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.51971385
177TP63_23658742_ChIP-Seq_EP156T_Human0.50371177
178KLF5_25053715_ChIP-Seq_YYC3_Human0.49813159
179RARB_24833708_ChIP-Seq_LIVER_Mouse0.49791862
180STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49142583
181CREB1_26743006_Chip-Seq_LNCaP_Human0.48830659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.87529210
2MP0002139_abnormal_hepatobiliary_system7.19378000
3MP0005085_abnormal_gallbladder_physiolo5.98203449
4MP0000569_abnormal_digit_pigmentation5.28343642
5MP0005365_abnormal_bile_salt5.24000702
6MP0008875_abnormal_xenobiotic_pharmacok5.06367609
7MP0001666_abnormal_nutrient_absorption4.31924696
8MP0003252_abnormal_bile_duct4.09006899
9MP0009840_abnormal_foam_cell3.86776665
10MP0003806_abnormal_nucleotide_metabolis3.66199758
11MP0010329_abnormal_lipoprotein_level3.50885771
12MP0008057_abnormal_DNA_replication2.62730787
13MP0001501_abnormal_sleep_pattern2.52727319
14MP0003646_muscle_fatigue2.44005061
15MP0004019_abnormal_vitamin_homeostasis2.35562264
16MP0005332_abnormal_amino_acid2.33224798
17MP0003724_increased_susceptibility_to2.23145543
18MP0005083_abnormal_biliary_tract2.14784969
19MP0000427_abnormal_hair_cycle2.12040053
20MP0005174_abnormal_tail_pigmentation2.08944020
21MP0005310_abnormal_salivary_gland2.04095957
22MP0003191_abnormal_cellular_cholesterol2.03863186
23MP0003045_fibrosis1.99497678
24MP0009697_abnormal_copulation1.91411412
25MP0000609_abnormal_liver_physiology1.84201551
26MP0002118_abnormal_lipid_homeostasis1.83255215
27MP0008961_abnormal_basal_metabolism1.80388086
28MP0004130_abnormal_muscle_cell1.73926313
29MP0002009_preneoplasia1.71093578
30MP0003868_abnormal_feces_composition1.66521221
31MP0010234_abnormal_vibrissa_follicle1.64356025
32MP0003195_calcinosis1.59689700
33MP0005551_abnormal_eye_electrophysiolog1.58742129
34MP0005319_abnormal_enzyme/_coenzyme1.57290229
35MP0005670_abnormal_white_adipose1.56160170
36MP0004264_abnormal_extraembryonic_tissu1.54407490
37MP0009046_muscle_twitch1.49243276
38MP0001764_abnormal_homeostasis1.48246080
39MP0002822_catalepsy1.43334183
40MP0000383_abnormal_hair_follicle1.42383601
41MP0001485_abnormal_pinna_reflex1.35620644
42MP0002138_abnormal_hepatobiliary_system1.32249412
43MP0001968_abnormal_touch/_nociception1.30291361
44MP0001800_abnormal_humoral_immune1.29706223
45MP0009643_abnormal_urine_homeostasis1.27430313
46MP0000462_abnormal_digestive_system1.26427660
47MP0005084_abnormal_gallbladder_morpholo1.25858185
48MP0005584_abnormal_enzyme/coenzyme_acti1.24959655
49MP0005451_abnormal_body_composition1.24012359
50MP0009745_abnormal_behavioral_response1.23814081
51MP0002254_reproductive_system_inflammat1.23664855
52MP0003183_abnormal_peptide_metabolism1.22059144
53MP0010386_abnormal_urinary_bladder1.22008514
54MP0004142_abnormal_muscle_tone1.20304126
55MP0003705_abnormal_hypodermis_morpholog1.19622507
56MP0001986_abnormal_taste_sensitivity1.17990570
57MP0002928_abnormal_bile_duct1.15354970
58MP0000015_abnormal_ear_pigmentation1.12600973
59MP0005386_behavior/neurological_phenoty1.12295891
60MP0004924_abnormal_behavior1.12295891
61MP0001486_abnormal_startle_reflex1.07452205
62MP0004484_altered_response_of1.05266181
63MP0002168_other_aberrant_phenotype1.04604177
64MP0000470_abnormal_stomach_morphology1.02776176
65MP0002064_seizures1.00568966
66MP0005671_abnormal_response_to0.98555022
67MP0002733_abnormal_thermal_nociception0.98325266
68MP0005636_abnormal_mineral_homeostasis0.97034330
69MP0001663_abnormal_digestive_system0.96730776
70MP0003787_abnormal_imprinting0.96069167
71MP0005645_abnormal_hypothalamus_physiol0.96015585
72MP0002876_abnormal_thyroid_physiology0.95656113
73MP0004043_abnormal_pH_regulation0.94462309
74MP0004147_increased_porphyrin_level0.93495563
75MP0001835_abnormal_antigen_presentation0.92621561
76MP0005381_digestive/alimentary_phenotyp0.91849974
77MP0003890_abnormal_embryonic-extraembry0.91213504
78MP0000685_abnormal_immune_system0.90841062
79MP0003656_abnormal_erythrocyte_physiolo0.89331804
80MP0003866_abnormal_defecation0.88179400
81MP0000598_abnormal_liver_morphology0.88155030
82MP0008004_abnormal_stomach_pH0.88129904
83MP0001970_abnormal_pain_threshold0.87829433
84MP0005448_abnormal_energy_balance0.87608026
85MP0002736_abnormal_nociception_after0.87274033
86MP0001790_abnormal_immune_system0.86705887
87MP0005387_immune_system_phenotype0.86705887
88MP0002067_abnormal_sensory_capabilities0.85895934
89MP0003186_abnormal_redox_activity0.85427736
90MP0001664_abnormal_digestion0.85052478
91MP0010678_abnormal_skin_adnexa0.84673594
92MP0002735_abnormal_chemical_nociception0.83793475
93MP0000538_abnormal_urinary_bladder0.83462230
94MP0009764_decreased_sensitivity_to0.83124814
95MP0010155_abnormal_intestine_physiology0.82876496
96MP0002272_abnormal_nervous_system0.82611443
97MP0005266_abnormal_metabolism0.82357235
98MP0001873_stomach_inflammation0.82346670
99MP0009379_abnormal_foot_pigmentation0.81544747
100MP0006082_CNS_inflammation0.81518090
101MP0009053_abnormal_anal_canal0.81344838
102MP0009642_abnormal_blood_homeostasis0.81285053
103MP0003879_abnormal_hair_cell0.81093568
104MP0000371_diluted_coat_color0.80047226
105MP0000604_amyloidosis0.79195057
106MP0008877_abnormal_DNA_methylation0.78826598
107MP0005376_homeostasis/metabolism_phenot0.76847444
108MP0002723_abnormal_immune_serum0.75751477
109MP0008872_abnormal_physiological_respon0.75004017
110MP0004145_abnormal_muscle_electrophysio0.74366458
111MP0003300_gastrointestinal_ulcer0.73418130
112MP0003718_maternal_effect0.73357352
113MP0006054_spinal_hemorrhage0.72069549
114MP0002796_impaired_skin_barrier0.71954345
115MP0002452_abnormal_antigen_presenting0.71824221
116MP0008469_abnormal_protein_level0.71759985
117MP0002572_abnormal_emotion/affect_behav0.71687605
118MP0005408_hypopigmentation0.71215573
119MP0002396_abnormal_hematopoietic_system0.71093353
120MP0009765_abnormal_xenobiotic_induced0.69370583
121MP0003633_abnormal_nervous_system0.68562899
122MP0009763_increased_sensitivity_to0.68462133
123MP0002638_abnormal_pupillary_reflex0.67323234
124MP0000477_abnormal_intestine_morphology0.66737805
125MP0003011_delayed_dark_adaptation0.66607676
126MP0004215_abnormal_myocardial_fiber0.65458222
127MP0002078_abnormal_glucose_homeostasis0.62801614
128MP0005647_abnormal_sex_gland0.59418509
129MP0005166_decreased_susceptibility_to0.56817215
130MP0002136_abnormal_kidney_physiology0.56239101
131MP0005334_abnormal_fat_pad0.55896878
132MP0005167_abnormal_blood-brain_barrier0.55835581
133MP0002971_abnormal_brown_adipose0.55800256
134MP0001756_abnormal_urination0.54612808
135MP0009384_cardiac_valve_regurgitation0.53006851
136MP0002132_abnormal_respiratory_system0.52668443
137MP0006036_abnormal_mitochondrial_physio0.50815488
138MP0003638_abnormal_response/metabolism_0.49092179
139MP0008873_increased_physiological_sensi0.46145383
140MP0005377_hearing/vestibular/ear_phenot0.45531660
141MP0003878_abnormal_ear_physiology0.45531660
142MP0004947_skin_inflammation0.45077424
143MP0000467_abnormal_esophagus_morphology0.43893057
144MP0001765_abnormal_ion_homeostasis0.43457758
145MP0005535_abnormal_body_temperature0.42023160
146MP0003953_abnormal_hormone_level0.41720924
147MP0005464_abnormal_platelet_physiology0.41310972
148MP0005220_abnormal_exocrine_pancreas0.40998430
149MP0003453_abnormal_keratinocyte_physiol0.40538327
150MP0010368_abnormal_lymphatic_system0.39093477
151MP0004782_abnormal_surfactant_physiolog0.38887108
152MP0009115_abnormal_fat_cell0.37112830
153MP0000537_abnormal_urethra_morphology0.37056141
154MP0000230_abnormal_systemic_arterial0.36898199
155MP0000579_abnormal_nail_morphology0.35775848
156MP0002098_abnormal_vibrissa_morphology0.35501580
157MP0005248_abnormal_Harderian_gland0.34721779
158MP0005395_other_phenotype0.33895710
159MP0001845_abnormal_inflammatory_respons0.32358737
160MP0001881_abnormal_mammary_gland0.31748715

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)7.46164030
2Intrahepatic cholestasis (HP:0001406)6.76122101
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.26692998
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.87864168
5Xanthomatosis (HP:0000991)5.87102132
6Abnormality of glutamine family amino acid metabolism (HP:0010902)5.85657894
7Deep venous thrombosis (HP:0002625)5.62350719
8Genetic anticipation (HP:0003743)5.44047377
9Conjugated hyperbilirubinemia (HP:0002908)5.17855955
10Hyperventilation (HP:0002883)5.15367293
11Hypolipoproteinemia (HP:0010981)5.09030028
12Prolonged partial thromboplastin time (HP:0003645)5.02522223
13Fat malabsorption (HP:0002630)4.91291529
14Acanthocytosis (HP:0001927)4.55144302
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42638642
16Epidermoid cyst (HP:0200040)4.33619656
17Ileus (HP:0002595)4.31307445
18Hyperglycinuria (HP:0003108)4.30909826
19Hyperammonemia (HP:0001987)4.25492731
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18006049
21Decreased circulating renin level (HP:0003351)4.16247355
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.09964790
23Hyperlipoproteinemia (HP:0010980)4.05417568
24Complement deficiency (HP:0004431)3.95087699
25Progressive cerebellar ataxia (HP:0002073)3.94830279
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.91146457
27Malnutrition (HP:0004395)3.88256492
28Abnormality of glycine metabolism (HP:0010895)3.86066639
29Abnormality of serine family amino acid metabolism (HP:0010894)3.86066639
30Pancreatic cysts (HP:0001737)3.81857327
31Protruding tongue (HP:0010808)3.76631330
32Hypercholesterolemia (HP:0003124)3.72706462
33Gaze-evoked nystagmus (HP:0000640)3.70152261
34Clumsiness (HP:0002312)3.67807822
35Hypoalphalipoproteinemia (HP:0003233)3.58817101
36Ketosis (HP:0001946)3.50621101
37Hypoglycemic coma (HP:0001325)3.50077478
38Congenital sensorineural hearing impairment (HP:0008527)3.43191044
39Hydroxyprolinuria (HP:0003080)3.43158074
40Abnormality of proline metabolism (HP:0010907)3.43158074
41Hyperglycinemia (HP:0002154)3.41366900
42Abnormality of the common coagulation pathway (HP:0010990)3.41342324
43Abnormality of pyrimidine metabolism (HP:0004353)3.34226189
44Hyperbilirubinemia (HP:0002904)3.31293580
45Joint hemorrhage (HP:0005261)3.31255628
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27572659
47Abnormality of methionine metabolism (HP:0010901)3.23371855
48Pancreatic fibrosis (HP:0100732)3.17606426
49Increased neuronal autofluorescent lipopigment (HP:0002074)3.14689583
50True hermaphroditism (HP:0010459)3.14612909
51Fair hair (HP:0002286)3.08607561
52Abnormality of fatty-acid metabolism (HP:0004359)3.07765471
53Abnormality of nucleobase metabolism (HP:0010932)3.06600274
54Metabolic acidosis (HP:0001942)3.02383460
55Poikilocytosis (HP:0004447)2.98822932
56Steatorrhea (HP:0002570)2.98090258
57Abnormality of the intrinsic pathway (HP:0010989)2.96781053
58Abnormality of purine metabolism (HP:0004352)2.92787316
59Abnormality of complement system (HP:0005339)2.90869176
60Abnormality of the renal cortex (HP:0011035)2.90851326
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.85162668
62Ketoacidosis (HP:0001993)2.80028535
63Abnormality of renin-angiotensin system (HP:0000847)2.77687444
64Right ventricular cardiomyopathy (HP:0011663)2.75586123
65Congenital stationary night blindness (HP:0007642)2.75083352
66Metabolic alkalosis (HP:0200114)2.70832891
67Febrile seizures (HP:0002373)2.69370711
68Stomach cancer (HP:0012126)2.69173508
69Attenuation of retinal blood vessels (HP:0007843)2.69095801
70Generalized hypopigmentation of hair (HP:0011358)2.68764618
71Autoimmune thrombocytopenia (HP:0001973)2.60914465
72Chronic hepatic failure (HP:0100626)2.57964640
73Abnormality of urine glucose concentration (HP:0011016)2.56972299
74Glycosuria (HP:0003076)2.56972299
75Chronic diarrhea (HP:0002028)2.56295492
76Skin nodule (HP:0200036)2.52104956
77Hepatocellular carcinoma (HP:0001402)2.50320772
78Cystic liver disease (HP:0006706)2.49941114
79Tubular atrophy (HP:0000092)2.49636040
80Vascular calcification (HP:0004934)2.49427204
81Pigmentary retinal degeneration (HP:0001146)2.46968813
82Dicarboxylic aciduria (HP:0003215)2.46823294
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46823294
84Hyperactive renin-angiotensin system (HP:0000841)2.46108868
85Lethargy (HP:0001254)2.41960576
86Abnormality of vitamin metabolism (HP:0100508)2.41425421
87Delayed CNS myelination (HP:0002188)2.40683569
88Dysmetric saccades (HP:0000641)2.40660891
89Cholecystitis (HP:0001082)2.40649122
90Abnormal gallbladder physiology (HP:0012438)2.40649122
91Increased cerebral lipofuscin (HP:0011813)2.40502883
92Molar tooth sign on MRI (HP:0002419)2.39211353
93Abnormality of midbrain morphology (HP:0002418)2.39211353
94Spontaneous abortion (HP:0005268)2.35064179
95Abnormality of serum amino acid levels (HP:0003112)2.31241046
96Inability to walk (HP:0002540)2.30530125
97Pancreatitis (HP:0001733)2.30211370
98Systemic lupus erythematosus (HP:0002725)2.28166654
99Abnormality of the renal medulla (HP:0100957)2.27810052
100Myocardial infarction (HP:0001658)2.27402526
101Optic neuritis (HP:0100653)2.26886857
102Retrobulbar optic neuritis (HP:0100654)2.26886857
103Abnormal gallbladder morphology (HP:0012437)2.26277590
104Absent speech (HP:0001344)2.25081784
105Hyperkalemia (HP:0002153)2.23418741
106Sensorimotor neuropathy (HP:0007141)2.23302263
107Cholelithiasis (HP:0001081)2.21533277
108Hypoglycemic seizures (HP:0002173)2.21024693
109Abdominal distention (HP:0003270)2.19740944
110Nephronophthisis (HP:0000090)2.19348062
111Cardiovascular calcification (HP:0011915)2.19071458
112Widely spaced teeth (HP:0000687)2.17108172
113Abolished electroretinogram (ERG) (HP:0000550)2.16776113
114Furrowed tongue (HP:0000221)2.15640941
115Late onset (HP:0003584)2.13565331
116Hypoplastic ischia (HP:0003175)2.13561398
117Irritability (HP:0000737)2.13411318
118Reticulocytosis (HP:0001923)2.13367696
119Orchitis (HP:0100796)2.12798200
120Progressive inability to walk (HP:0002505)2.11972284
121Large for gestational age (HP:0001520)2.11601648
122Amyloidosis (HP:0011034)2.11064875
123Cupped ribs (HP:0000887)2.10886232
124Increased mean platelet volume (HP:0011877)2.10687008
125Hypochromic microcytic anemia (HP:0004840)2.07264381
126Spastic diplegia (HP:0001264)2.07181981
127Esophageal varix (HP:0002040)2.07070769
128Abnormal cartilage morphology (HP:0002763)2.05328653
129Broad-based gait (HP:0002136)2.04243766
130Gout (HP:0001997)2.01831619
131Abnormality of potassium homeostasis (HP:0011042)2.01539716
132Abnormality of the ischium (HP:0003174)2.01438290
133Vomiting (HP:0002013)2.01391230
134Nephrolithiasis (HP:0000787)2.00646369
135Patellar aplasia (HP:0006443)1.99449470
136Proximal tubulopathy (HP:0000114)1.96626609
137Cerebral edema (HP:0002181)1.95751865
138Symptomatic seizures (HP:0011145)1.95345044
139Generalized aminoaciduria (HP:0002909)1.93781217
140Facial diplegia (HP:0001349)1.93741238
141Alkalosis (HP:0001948)1.93008379
142Abnormality of the gallbladder (HP:0005264)1.92920321
143Widely patent fontanelles and sutures (HP:0004492)1.91802417
144Chorioretinal atrophy (HP:0000533)1.91765779
145Abnormal delayed hypersensitivity skin test (HP:0002963)1.90144928
146Potter facies (HP:0002009)1.89805773
147Facial shape deformation (HP:0011334)1.89805773
148Medial flaring of the eyebrow (HP:0010747)1.89010940
149Hypoplastic labia majora (HP:0000059)1.88443415
150Nausea (HP:0002018)1.88348932
151Hematochezia (HP:0002573)1.88266626
152Glomerulonephritis (HP:0000099)1.88240911
153Abnormality of alanine metabolism (HP:0010916)1.87965928
154Hyperalaninemia (HP:0003348)1.87965928
155Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87965928
156Abnormality of chloride homeostasis (HP:0011422)1.87717772
157Abnormal tarsal ossification (HP:0008369)1.87243317
158Hyperaldosteronism (HP:0000859)1.85396044
159Rickets (HP:0002748)1.84848417
160Polycythemia (HP:0001901)1.84826714
161Abnormality of transition element cation homeostasis (HP:0011030)1.83437213
162Urinary bladder sphincter dysfunction (HP:0002839)1.82473323
163Bony spicule pigmentary retinopathy (HP:0007737)1.81739284
164Abnormality of the nasal septum (HP:0000419)1.80671119
165Myositis (HP:0100614)1.80026932
166Abnormal biliary tract morphology (HP:0012440)1.78639647
167Congenital hepatic fibrosis (HP:0002612)1.78435148
168Abnormality of the labia majora (HP:0012881)1.76548650
169Preaxial foot polydactyly (HP:0001841)1.75659507
170Dialeptic seizures (HP:0011146)1.75470032
171Hypokalemia (HP:0002900)1.75388603
172Aplasia/Hypoplasia of the patella (HP:0006498)1.75340019
173Postural instability (HP:0002172)1.75330218
174Abnormality of T cell number (HP:0011839)1.74249803
175Poor coordination (HP:0002370)1.74043578
176Keratoconjunctivitis (HP:0001096)1.72696096
177Polydipsia (HP:0001959)1.72497292
178Abnormal drinking behavior (HP:0030082)1.72497292
179Abnormality of binocular vision (HP:0011514)1.71637566
180Diplopia (HP:0000651)1.71637566
181Macroglossia (HP:0000158)1.70363252
182Amelogenesis imperfecta (HP:0000705)1.69743748
183Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69247928
184Absence seizures (HP:0002121)1.69084653
185Hemiplegia (HP:0002301)1.67935823
186Abnormality of the vitamin B12 metabolism (HP:0004341)1.67108588
187Abnormality of the axillary hair (HP:0100134)1.66232515
188Abnormality of secondary sexual hair (HP:0009888)1.66232515
189Decreased central vision (HP:0007663)1.65457602
190Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64698870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.71686323
2ACVR1B5.43481131
3MST1R4.65963539
4LMTK24.06144559
5BCKDK3.70953875
6MST43.26453681
7ERN13.16171023
8ERBB42.77090732
9BMPR1B2.76426942
10GRK62.61397284
11FGFR42.44068218
12PRKG22.39236234
13SIK12.28334848
14TAOK32.13746161
15PTK62.01707617
16NME11.95977138
17RIPK11.92454702
18INSRR1.88497107
19MAP3K21.85196519
20ADRBK21.83914056
21OXSR11.82543631
22MAP2K21.78393858
23MAP3K101.77017329
24EPHA21.71875927
25AKT31.68551502
26NUAK11.66796591
27MET1.56545365
28MAPK111.51982284
29MAP2K61.50780036
30LATS11.47179741
31TXK1.41829631
32EPHB21.39208287
33STK391.37537755
34PKN21.29485234
35ADRBK11.27961129
36BLK1.27309198
37MAP3K31.26928083
38TBK11.24696836
39ERBB21.22751325
40TEC1.20404500
41PRKAA21.19565918
42WNK31.19325300
43MAP2K41.17168301
44CASK1.17114273
45TYK21.16488592
46NLK1.16230539
47MAP3K71.13944665
48PBK1.13662322
49IRAK11.13472217
50MYLK1.11445576
51TNIK1.09642482
52PIK3CG1.07181066
53MAPK131.06707049
54MKNK21.04974442
55SGK21.00852763
56TGFBR10.97970129
57PIK3CA0.97319092
58TRPM70.95552274
59PTK2B0.95316148
60WNK40.93541448
61NTRK30.93213901
62CAMKK20.90511537
63IRAK30.89644882
64WNK10.86935999
65MAP2K10.86363079
66MAP3K110.84948072
67MELK0.82059814
68MAP3K40.80382877
69CAMK1D0.79774958
70PTK20.79477082
71FLT30.77705224
72PINK10.75945916
73ITK0.75273387
74CAMK1G0.72798544
75EPHB10.70704880
76NEK90.70429234
77ABL20.69308814
78STK380.69069469
79BTK0.68640338
80PRKAA10.68153338
81STK240.66968895
82RIPK40.66954049
83STK110.66740711
84DAPK20.65230445
85MAP3K140.64531456
86GRK10.64526371
87JAK20.64514430
88BMX0.64319400
89TNK20.64182587
90MAP2K30.63701955
91IKBKE0.63563645
92CDK120.63497227
93KIT0.62158968
94PDPK10.61370568
95SYK0.61345877
96ZAK0.59873470
97CAMK2G0.59522213
98CDK60.59250785
99TESK10.58797016
100MAP4K10.58237545
101MAPK40.58112462
102PRKACG0.57910837
103SGK2230.57713907
104SGK4940.57713907
105STK100.56677247
106YES10.53280320
107CSK0.52711540
108PRKCE0.52581477
109PRKCZ0.51228565
110CHUK0.50437189
111SIK20.49470452
112BRD40.49377434
113TLK10.48646547
114TAOK10.47907373
115FER0.47352676
116KDR0.46330390
117SGK10.45882706
118MAPK150.45162451
119DYRK1B0.44959790
120CAMK40.44336067
121STK38L0.44247704
122MATK0.43967914
123IRAK40.43060355
124PRKCI0.42718453
125LCK0.42610209
126KSR20.42284624
127MAP3K10.42143682
128LYN0.41645719
129TIE10.40974140
130PDK20.40687358
131PRKCA0.40057513
132GSK3A0.39881412
133MAP4K20.39192884
134MAPKAPK30.39121769
135PAK30.38715087
136JAK10.38089500
137IKBKB0.37958165
138RPS6KA60.37951108
139MAP3K80.37682854
140HCK0.37193500
141PRKCQ0.36979682
142SGK30.36115290
143CDK190.35463182
144FGFR20.34961871
145PDGFRB0.33354883
146CAMK10.33346048
147PDK10.33213457
148MAPK70.33203839
149BRSK20.32996459
150RET0.32783840
151TRIB30.32295614
152ICK0.32143054
153PDK30.25222969
154PDK40.25222969
155STK30.24754688
156IGF1R0.24124438
157DDR20.23922216
158TESK20.23601549
159TTK0.21940256
160EPHA30.21627186
161FGFR30.18121312
162PRKCD0.14570122
163SRC0.14076758
164CSNK1A10.13803709
165PRKCB0.12675250
166EGFR0.11028040

Predicted pathways (KEGG)

RankGene SetZ-score
1African trypanosomiasis_Homo sapiens_hsa051435.51295363
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.53065781
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47491323
4Nitrogen metabolism_Homo sapiens_hsa009103.05206535
5Fat digestion and absorption_Homo sapiens_hsa049752.98679152
6Arginine biosynthesis_Homo sapiens_hsa002202.73783353
7Caffeine metabolism_Homo sapiens_hsa002322.54625125
8Tryptophan metabolism_Homo sapiens_hsa003802.52557454
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39638283
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36754004
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.33419863
12Fatty acid degradation_Homo sapiens_hsa000712.28233652
13Sulfur metabolism_Homo sapiens_hsa009202.22525154
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12979835
15Vitamin digestion and absorption_Homo sapiens_hsa049772.11407197
16Histidine metabolism_Homo sapiens_hsa003402.10988279
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05695317
18Starch and sucrose metabolism_Homo sapiens_hsa005001.98805659
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98377901
20Chemical carcinogenesis_Homo sapiens_hsa052041.97682548
21Bile secretion_Homo sapiens_hsa049761.95665577
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94600375
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89480767
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88135714
25PPAR signaling pathway_Homo sapiens_hsa033201.87774871
26Complement and coagulation cascades_Homo sapiens_hsa046101.86934276
27Butanoate metabolism_Homo sapiens_hsa006501.82438573
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.81142348
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.77087737
30Folate biosynthesis_Homo sapiens_hsa007901.76702862
31Peroxisome_Homo sapiens_hsa041461.76492670
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71179724
33Retinol metabolism_Homo sapiens_hsa008301.67254978
34Dorso-ventral axis formation_Homo sapiens_hsa043201.57117239
35beta-Alanine metabolism_Homo sapiens_hsa004101.52837304
36Propanoate metabolism_Homo sapiens_hsa006401.52095243
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.49623600
38Nicotine addiction_Homo sapiens_hsa050331.49444410
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48621684
40Fatty acid metabolism_Homo sapiens_hsa012121.46321621
41Mineral absorption_Homo sapiens_hsa049781.38875435
42Renin-angiotensin system_Homo sapiens_hsa046141.32531884
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30489492
44Selenocompound metabolism_Homo sapiens_hsa004501.29729962
45Phenylalanine metabolism_Homo sapiens_hsa003601.28684842
46ABC transporters_Homo sapiens_hsa020101.28595926
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28047732
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.26980799
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26720028
50Pyruvate metabolism_Homo sapiens_hsa006201.26618918
51Galactose metabolism_Homo sapiens_hsa000521.21496936
52Graft-versus-host disease_Homo sapiens_hsa053321.20759808
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20725172
54Taste transduction_Homo sapiens_hsa047421.17806633
55Serotonergic synapse_Homo sapiens_hsa047261.16148366
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15036775
57Glutathione metabolism_Homo sapiens_hsa004801.14781043
58Tyrosine metabolism_Homo sapiens_hsa003501.08538846
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08282453
60Carbon metabolism_Homo sapiens_hsa012001.07952390
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07603747
62Staphylococcus aureus infection_Homo sapiens_hsa051501.05753263
63Phototransduction_Homo sapiens_hsa047441.05748194
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04807036
65Arginine and proline metabolism_Homo sapiens_hsa003301.04686363
66Vascular smooth muscle contraction_Homo sapiens_hsa042701.03125756
67Steroid biosynthesis_Homo sapiens_hsa001001.03087511
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01723720
69Morphine addiction_Homo sapiens_hsa050321.00478319
70Biosynthesis of amino acids_Homo sapiens_hsa012300.98887145
71Salivary secretion_Homo sapiens_hsa049700.98593950
72Glycerolipid metabolism_Homo sapiens_hsa005610.97724222
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97377947
74Asthma_Homo sapiens_hsa053100.94736453
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.94240905
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93044034
77Fatty acid elongation_Homo sapiens_hsa000620.92815429
78Renin secretion_Homo sapiens_hsa049240.88001009
79Calcium signaling pathway_Homo sapiens_hsa040200.86724402
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86334858
81Circadian entrainment_Homo sapiens_hsa047130.85801959
82Fructose and mannose metabolism_Homo sapiens_hsa000510.85592429
83Glutamatergic synapse_Homo sapiens_hsa047240.84855679
84Long-term depression_Homo sapiens_hsa047300.84703481
85Cholinergic synapse_Homo sapiens_hsa047250.81932418
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80446540
87Insulin secretion_Homo sapiens_hsa049110.79743528
88Allograft rejection_Homo sapiens_hsa053300.77208111
89Platelet activation_Homo sapiens_hsa046110.76855663
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75303776
91Autoimmune thyroid disease_Homo sapiens_hsa053200.74707774
92Gastric acid secretion_Homo sapiens_hsa049710.72872553
93Olfactory transduction_Homo sapiens_hsa047400.72488245
94Sulfur relay system_Homo sapiens_hsa041220.72185474
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71719007
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71449897
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70890133
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69225347
99Pentose phosphate pathway_Homo sapiens_hsa000300.65390337
100cAMP signaling pathway_Homo sapiens_hsa040240.63557686
101Lysine degradation_Homo sapiens_hsa003100.63520388
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61845107
103FoxO signaling pathway_Homo sapiens_hsa040680.57726973
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56740585
105Protein digestion and absorption_Homo sapiens_hsa049740.55809839
106Type I diabetes mellitus_Homo sapiens_hsa049400.55625793
107Leishmaniasis_Homo sapiens_hsa051400.54871470
108Oxytocin signaling pathway_Homo sapiens_hsa049210.53718494
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.52875397
110GABAergic synapse_Homo sapiens_hsa047270.52859890
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50792268
112Dopaminergic synapse_Homo sapiens_hsa047280.50479932
113Choline metabolism in cancer_Homo sapiens_hsa052310.50164051
114TNF signaling pathway_Homo sapiens_hsa046680.49650897
115Metabolic pathways_Homo sapiens_hsa011000.48223839
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47358814
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46944706
118Fatty acid biosynthesis_Homo sapiens_hsa000610.46092733
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43327199
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42334958
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42191189
122Chemokine signaling pathway_Homo sapiens_hsa040620.41985396
123T cell receptor signaling pathway_Homo sapiens_hsa046600.41904660
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.41867431
125Cocaine addiction_Homo sapiens_hsa050300.41777616
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41322978
127Linoleic acid metabolism_Homo sapiens_hsa005910.40450804
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39889186
129Tuberculosis_Homo sapiens_hsa051520.39463375
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.35632467
131Vitamin B6 metabolism_Homo sapiens_hsa007500.31054415
132One carbon pool by folate_Homo sapiens_hsa006700.26938200
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21515099
134Insulin resistance_Homo sapiens_hsa049310.13609915
135Thyroid hormone synthesis_Homo sapiens_hsa049180.12187516
136Arachidonic acid metabolism_Homo sapiens_hsa005900.08933775
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.04241708
138Prion diseases_Homo sapiens_hsa050200.03199932
139Pertussis_Homo sapiens_hsa05133-0.1795997
140Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1747584
141Bladder cancer_Homo sapiens_hsa05219-0.1386020
142Pancreatic secretion_Homo sapiens_hsa04972-0.1369798
143Type II diabetes mellitus_Homo sapiens_hsa04930-0.1310097
144Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1306919
145Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1243610
146Glucagon signaling pathway_Homo sapiens_hsa04922-0.0945195
147AMPK signaling pathway_Homo sapiens_hsa04152-0.0705556
148Ether lipid metabolism_Homo sapiens_hsa00565-0.0666279
149Hepatitis C_Homo sapiens_hsa05160-0.0287205
150Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0274769
151Sphingolipid metabolism_Homo sapiens_hsa00600-0.0113613
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0110816

Most similar genes based on co-expression Upload to Enrichr

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