ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	indole-containing compound catabolic process (GO:0042436)	4.46325272
2	indolalkylamine catabolic process (GO:0046218)	4.46325272
3	tryptophan catabolic process (GO:0006569)	4.46325272
4	kynurenine metabolic process (GO:0070189)	4.29780367
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.25152282
6	indolalkylamine metabolic process (GO:0006586)	4.24164183
7	tachykinin receptor signaling pathway (GO:0007217)	4.18245959
8	regulation of hippo signaling (GO:0035330)	4.16042776
9	detection of light stimulus involved in sensory perception (GO:0050962)	3.99486189
10	detection of light stimulus involved in visual perception (GO:0050908)	3.99486189
11	behavioral response to ethanol (GO:0048149)	3.96202564
12	fucose catabolic process (GO:0019317)	3.88619189
13	L-fucose metabolic process (GO:0042354)	3.88619189
14	L-fucose catabolic process (GO:0042355)	3.88619189
15	photoreceptor cell maintenance (GO:0045494)	3.84732725
16	cellular ketone body metabolic process (GO:0046950)	3.83412290
17	neural tube formation (GO:0001841)	3.82596277
18	response to pheromone (GO:0019236)	3.77423380
19	signal peptide processing (GO:0006465)	3.75803245
20	benzene-containing compound metabolic process (GO:0042537)	3.71290200
21	ketone body metabolic process (GO:1902224)	3.69482168
22	behavioral response to nicotine (GO:0035095)	3.66846050
23	tryptophan metabolic process (GO:0006568)	3.58914662
24	retinal cone cell development (GO:0046549)	3.55310156
25	protein localization to cilium (GO:0061512)	3.54385021
26	acrosome assembly (GO:0001675)	3.43469349
27	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.37605359
28	cilium or flagellum-dependent cell motility (GO:0001539)	3.37046611
29	axoneme assembly (GO:0035082)	3.30961263
30	reflex (GO:0060004)	3.30629078
31	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.26987349
32	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.23962901
33	prenylation (GO:0097354)	3.23955676
34	protein prenylation (GO:0018342)	3.23955676
35	auditory receptor cell stereocilium organization (GO:0060088)	3.21915524
36	establishment of protein localization to Golgi (GO:0072600)	3.14341090
37	amine catabolic process (GO:0009310)	3.11540102
38	cellular biogenic amine catabolic process (GO:0042402)	3.11540102
39	neuronal action potential (GO:0019228)	3.09014133
40	positive regulation of developmental pigmentation (GO:0048087)	3.07200370
41	indole-containing compound metabolic process (GO:0042430)	3.07180154
42	piRNA metabolic process (GO:0034587)	3.04898408
43	DNA double-strand break processing (GO:0000729)	3.03203414
44	cilium morphogenesis (GO:0060271)	2.98045277
45	gamma-aminobutyric acid transport (GO:0015812)	2.96930964
46	inner ear receptor stereocilium organization (GO:0060122)	2.94196139
47	regulation of gene silencing by RNA (GO:0060966)	2.86858286
48	regulation of posttranscriptional gene silencing (GO:0060147)	2.86858286
49	regulation of gene silencing by miRNA (GO:0060964)	2.86858286
50	regulation of pigment cell differentiation (GO:0050932)	2.86188426
51	sphingoid metabolic process (GO:0046519)	2.85625514
52	regulation of cilium movement (GO:0003352)	2.84938706
53	regulation of protein glycosylation (GO:0060049)	2.84175827
54	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.81677400
55	regulation of meiosis I (GO:0060631)	2.80652864
56	NAD biosynthetic process (GO:0009435)	2.79709714
57	double-strand break repair via homologous recombination (GO:0000724)	2.78187886
58	recombinational repair (GO:0000725)	2.77064169
59	oxidative demethylation (GO:0070989)	2.76677568
60	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.76326003
61	replication fork processing (GO:0031297)	2.76104921
62	nonmotile primary cilium assembly (GO:0035058)	2.75883392
63	aromatic amino acid family catabolic process (GO:0009074)	2.75360972
64	protein K11-linked deubiquitination (GO:0035871)	2.73791736
65	mannosylation (GO:0097502)	2.73773372
66	negative regulation of mast cell activation (GO:0033004)	2.72290579
67	reciprocal DNA recombination (GO:0035825)	2.71973324
68	reciprocal meiotic recombination (GO:0007131)	2.71973324
69	righting reflex (GO:0060013)	2.71380116
70	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.71151256
71	cilium organization (GO:0044782)	2.70588356
72	rhodopsin mediated signaling pathway (GO:0016056)	2.69075439
73	cilium assembly (GO:0042384)	2.68924993
74	platelet dense granule organization (GO:0060155)	2.68400262
75	drug catabolic process (GO:0042737)	2.67688397
76	C4-dicarboxylate transport (GO:0015740)	2.67341793
77	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.65896346
78	response to nitrosative stress (GO:0051409)	2.65212904
79	dopamine transport (GO:0015872)	2.63817674
80	DNA methylation involved in gamete generation (GO:0043046)	2.62693064
81	transmission of nerve impulse (GO:0019226)	2.62477293
82	serotonin metabolic process (GO:0042428)	2.57757316
83	photoreceptor cell development (GO:0042461)	2.57305811
84	cellular response to sterol (GO:0036315)	2.56688636
85	sulfation (GO:0051923)	2.52477669
86	cAMP catabolic process (GO:0006198)	2.52234685
87	membrane depolarization during action potential (GO:0086010)	2.52167139
88	protein polyglutamylation (GO:0018095)	2.50641868
89	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.49643184
90	L-methionine salvage (GO:0071267)	2.48468127
91	L-methionine biosynthetic process (GO:0071265)	2.48468127
92	amino acid salvage (GO:0043102)	2.48468127
93	regulation of uterine smooth muscle contraction (GO:0070472)	2.48285559
94	DNA deamination (GO:0045006)	2.47311485
95	aromatic amino acid family metabolic process (GO:0009072)	2.45351558
96	multicellular organism reproduction (GO:0032504)	2.43981218
97	protein targeting to Golgi (GO:0000042)	2.43582989
98	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.43110336
99	visual perception (GO:0007601)	2.41780901
100	cyclic nucleotide catabolic process (GO:0009214)	2.41354384

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.67730937
2	VDR_22108803_ChIP-Seq_LS180_Human	3.33433440
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.15156927
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.02724166
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.81745855
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77753849
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.41589722
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.39174097
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.33947520
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31642894
11	P300_19829295_ChIP-Seq_ESCs_Human	2.25521564
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.20837661
13	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.17368734
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.13978495
15	FUS_26573619_Chip-Seq_HEK293_Human	2.07962397
16	ER_23166858_ChIP-Seq_MCF-7_Human	2.06744593
17	EWS_26573619_Chip-Seq_HEK293_Human	2.06272738
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.05019348
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.01707811
20	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.98128631
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.91184998
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.90498337
23	STAT3_23295773_ChIP-Seq_U87_Human	1.88709188
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.87039319
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.81970437
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76569533
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.74772505
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.73256752
29	TCF4_23295773_ChIP-Seq_U87_Human	1.69104553
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67289506
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.67289506
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.56921349
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.56848422
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.54618736
35	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54558093
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53961926
37	AR_25329375_ChIP-Seq_VCAP_Human	1.53798796
38	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.50598346
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50530787
40	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48398639
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44475267
42	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44475267
43	TCF4_22108803_ChIP-Seq_LS180_Human	1.44287917
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42399935
45	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.42000380
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41909401
47	AR_21572438_ChIP-Seq_LNCaP_Human	1.41834529
48	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41757763
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.41757763
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41346427
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40868235
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39148724
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37809296
54	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.36485001
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.36068871
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35576464
57	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.35269000
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34417038
59	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.33851189
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32001339
61	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30496824
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27285776
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.27056651
64	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25863175
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.25532362
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.25438008
67	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.25206246
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21879717
69	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.19980588
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18539847
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18463311
72	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.16910532
73	TP53_16413492_ChIP-PET_HCT116_Human	1.16460312
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15653345
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13054362
76	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12186307
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11743249
78	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.11314341
79	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.10617786
80	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10240358
81	P300_18555785_Chip-Seq_ESCs_Mouse	1.09358586
82	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.08838760
83	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08353376
84	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.08191080
85	KDM2B_26808549_Chip-Seq_REH_Human	1.07913670
86	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07360097
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05901738
88	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.05154945
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04499483
90	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.04174540
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03950905
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03950905
93	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03266719
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02401623
95	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01463522
96	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00654856
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.00322511
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99159162
99	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.98890174
100	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.97655087

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.25893433
2	MP0003195_calcinosis	3.15384681
3	MP0005551_abnormal_eye_electrophysiolog	3.03271952
4	MP0003646_muscle_fatigue	2.93942386
5	MP0001501_abnormal_sleep_pattern	2.56165280
6	MP0002102_abnormal_ear_morphology	2.55790852
7	MP0008877_abnormal_DNA_methylation	2.47853619
8	MP0001968_abnormal_touch/_nociception	2.38146032
9	MP0003136_yellow_coat_color	2.32214818
10	MP0000372_irregular_coat_pigmentation	2.27859339
11	MP0004043_abnormal_pH_regulation	2.26507933
12	MP0002736_abnormal_nociception_after	2.24913176
13	MP0009046_muscle_twitch	2.18456822
14	MP0000427_abnormal_hair_cycle	2.10532904
15	MP0006054_spinal_hemorrhage	2.09030452
16	MP0001984_abnormal_olfaction	2.08888066
17	MP0005253_abnormal_eye_physiology	1.92411117
18	MP0003880_abnormal_central_pattern	1.90692085
19	MP0006276_abnormal_autonomic_nervous	1.88869440
20	MP0001486_abnormal_startle_reflex	1.80212958
21	MP0009745_abnormal_behavioral_response	1.79500267
22	MP0002837_dystrophic_cardiac_calcinosis	1.79231535
23	MP0008057_abnormal_DNA_replication	1.74675668
24	MP0002876_abnormal_thyroid_physiology	1.74371109
25	MP0001485_abnormal_pinna_reflex	1.74323056
26	MP0005646_abnormal_pituitary_gland	1.72036939
27	MP0004147_increased_porphyrin_level	1.70117863
28	MP0005085_abnormal_gallbladder_physiolo	1.68976374
29	MP0008872_abnormal_physiological_respon	1.67452659
30	MP0010386_abnormal_urinary_bladder	1.66404110
31	MP0005310_abnormal_salivary_gland	1.53468900
32	MP0002272_abnormal_nervous_system	1.49933621
33	MP0003950_abnormal_plasma_membrane	1.47798760
34	MP0002938_white_spotting	1.43564908
35	MP0006072_abnormal_retinal_apoptosis	1.40854638
36	MP0005670_abnormal_white_adipose	1.40301589
37	MP0002638_abnormal_pupillary_reflex	1.40010990
38	MP0000383_abnormal_hair_follicle	1.36785753
39	MP0003045_fibrosis	1.34850644
40	MP0005174_abnormal_tail_pigmentation	1.31859729
41	MP0005645_abnormal_hypothalamus_physiol	1.31180339
42	MP0005171_absent_coat_pigmentation	1.27292866
43	MP0004215_abnormal_myocardial_fiber	1.27290815
44	MP0001529_abnormal_vocalization	1.26352790
45	MP0005410_abnormal_fertilization	1.26268927
46	MP0001986_abnormal_taste_sensitivity	1.25544575
47	MP0004142_abnormal_muscle_tone	1.24870054
48	MP0002138_abnormal_hepatobiliary_system	1.22799089
49	MP0002653_abnormal_ependyma_morphology	1.22527107
50	MP0002735_abnormal_chemical_nociception	1.20949171
51	MP0002572_abnormal_emotion/affect_behav	1.20558879
52	MP0005386_behavior/neurological_phenoty	1.20296169
53	MP0004924_abnormal_behavior	1.20296169
54	MP0002928_abnormal_bile_duct	1.19772615
55	MP0003252_abnormal_bile_duct	1.18959301
56	MP0003787_abnormal_imprinting	1.17900888
57	MP0001970_abnormal_pain_threshold	1.16190436
58	MP0000230_abnormal_systemic_arterial	1.13995795
59	MP0008875_abnormal_xenobiotic_pharmacok	1.12113310
60	MP0001764_abnormal_homeostasis	1.10802628
61	MP0005075_abnormal_melanosome_morpholog	1.08520548
62	MP0002557_abnormal_social/conspecific_i	1.07602460
63	MP0002064_seizures	1.07558765
64	MP0002067_abnormal_sensory_capabilities	1.07444642
65	MP0000631_abnormal_neuroendocrine_gland	1.02755386
66	MP0005195_abnormal_posterior_eye	1.00866915
67	MP0002733_abnormal_thermal_nociception	0.98360204
68	MP0003635_abnormal_synaptic_transmissio	0.98263076
69	MP0002090_abnormal_vision	0.98103639
70	MP0002229_neurodegeneration	0.97164369
71	MP0004885_abnormal_endolymph	0.96947146
72	MP0002751_abnormal_autonomic_nervous	0.95651175
73	MP0002168_other_aberrant_phenotype	0.91872251
74	MP0005377_hearing/vestibular/ear_phenot	0.91477793
75	MP0003878_abnormal_ear_physiology	0.91477793
76	MP0003943_abnormal_hepatobiliary_system	0.91313033
77	MP0004133_heterotaxia	0.90355083
78	MP0003698_abnormal_male_reproductive	0.89282265
79	MP0001324_abnormal_eye_pigmentation	0.89103738
80	MP0008058_abnormal_DNA_repair	0.88780819
81	MP0002095_abnormal_skin_pigmentation	0.88565686
82	MP0008775_abnormal_heart_ventricle	0.88268894
83	MP0003633_abnormal_nervous_system	0.88175064
84	MP0004085_abnormal_heartbeat	0.88038751
85	MP0002734_abnormal_mechanical_nocicepti	0.87259553
86	MP0003718_maternal_effect	0.84901303
87	MP0005167_abnormal_blood-brain_barrier	0.84440067
88	MP0002063_abnormal_learning/memory/cond	0.84201668
89	MP0005084_abnormal_gallbladder_morpholo	0.83452606
90	MP0009697_abnormal_copulation	0.83360621
91	MP0002752_abnormal_somatic_nervous	0.83268808
92	MP0000538_abnormal_urinary_bladder	0.81971081
93	MP0006292_abnormal_olfactory_placode	0.81859203
94	MP0002160_abnormal_reproductive_system	0.81726812
95	MP0005389_reproductive_system_phenotype	0.81565316
96	MP0009780_abnormal_chondrocyte_physiolo	0.79689131
97	MP0004145_abnormal_muscle_electrophysio	0.78387742
98	MP0004484_altered_response_of	0.77762058
99	MP0000015_abnormal_ear_pigmentation	0.77712396
100	MP0001929_abnormal_gametogenesis	0.75640219

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.56657343
2	Pancreatic fibrosis (HP:0100732)	4.11814779
3	True hermaphroditism (HP:0010459)	3.94090597
4	Gaze-evoked nystagmus (HP:0000640)	3.77773921
5	Molar tooth sign on MRI (HP:0002419)	3.62034943
6	Abnormality of midbrain morphology (HP:0002418)	3.62034943
7	Medial flaring of the eyebrow (HP:0010747)	3.53756795
8	Attenuation of retinal blood vessels (HP:0007843)	3.50697313
9	Congenital stationary night blindness (HP:0007642)	3.43750839
10	Abnormality of the renal cortex (HP:0011035)	3.41452779
11	Progressive inability to walk (HP:0002505)	3.34926556
12	Nephronophthisis (HP:0000090)	3.34153299
13	Chronic hepatic failure (HP:0100626)	3.29113572
14	Type II lissencephaly (HP:0007260)	3.23334968
15	Abnormality of the renal medulla (HP:0100957)	3.22954085
16	Hyperventilation (HP:0002883)	3.21106316
17	Gait imbalance (HP:0002141)	3.11549499
18	Abolished electroretinogram (ERG) (HP:0000550)	3.05506186
19	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.05350661
20	Congenital primary aphakia (HP:0007707)	3.01529040
21	Renal cortical cysts (HP:0000803)	3.00857203
22	Febrile seizures (HP:0002373)	2.87356651
23	Cystic liver disease (HP:0006706)	2.87110116
24	Nephrogenic diabetes insipidus (HP:0009806)	2.75503864
25	Genital tract atresia (HP:0001827)	2.69740605
26	Inability to walk (HP:0002540)	2.69426187
27	Congenital sensorineural hearing impairment (HP:0008527)	2.66655183
28	Keratoconus (HP:0000563)	2.64102989
29	Increased corneal curvature (HP:0100692)	2.64102989
30	Bony spicule pigmentary retinopathy (HP:0007737)	2.63154839
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.61684614
32	Abnormality of macular pigmentation (HP:0008002)	2.60115951
33	Cerebellar dysplasia (HP:0007033)	2.58279601
34	Stomach cancer (HP:0012126)	2.55609878
35	Chorioretinal atrophy (HP:0000533)	2.45927132
36	Vaginal atresia (HP:0000148)	2.45516045
37	Genetic anticipation (HP:0003743)	2.43521284
38	Hypothermia (HP:0002045)	2.42343951
39	Progressive cerebellar ataxia (HP:0002073)	2.41853338
40	Decreased central vision (HP:0007663)	2.41814489
41	Absent speech (HP:0001344)	2.39431331
42	Central scotoma (HP:0000603)	2.35907553
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.33920928
44	Abnormality of alanine metabolism (HP:0010916)	2.33920928
45	Hyperalaninemia (HP:0003348)	2.33920928
46	Broad-based gait (HP:0002136)	2.30354519
47	Fair hair (HP:0002286)	2.28432780
48	Sclerocornea (HP:0000647)	2.22492030
49	Congenital hepatic fibrosis (HP:0002612)	2.20873036
50	Pendular nystagmus (HP:0012043)	2.13226777
51	Poor coordination (HP:0002370)	2.12589627
52	Scotoma (HP:0000575)	2.12253903
53	Abnormal protein glycosylation (HP:0012346)	2.09759312
54	Abnormal glycosylation (HP:0012345)	2.09759312
55	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.09759312
56	Abnormal protein N-linked glycosylation (HP:0012347)	2.09759312
57	Tubular atrophy (HP:0000092)	2.09458915
58	Thyroiditis (HP:0100646)	2.08435040
59	Abnormal drinking behavior (HP:0030082)	2.07889150
60	Polydipsia (HP:0001959)	2.07889150
61	Type I transferrin isoform profile (HP:0003642)	2.04603961
62	Retinal dysplasia (HP:0007973)	2.03629208
63	Intestinal atresia (HP:0011100)	2.02683772
64	Postaxial foot polydactyly (HP:0001830)	2.01894335
65	Furrowed tongue (HP:0000221)	1.99629881
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.99575213
67	Facial diplegia (HP:0001349)	1.99036911
68	Astigmatism (HP:0000483)	1.98517840
69	Focal seizures (HP:0007359)	1.98287581
70	Clumsiness (HP:0002312)	1.98044144
71	Short tibia (HP:0005736)	1.97388366
72	Retinitis pigmentosa (HP:0000510)	1.96013709
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.95932208
74	Amelogenesis imperfecta (HP:0000705)	1.93859567
75	Protruding tongue (HP:0010808)	1.93421576
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.93415363
77	Decreased circulating renin level (HP:0003351)	1.93179033
78	Lissencephaly (HP:0001339)	1.92839069
79	Constricted visual fields (HP:0001133)	1.92597799
80	Large for gestational age (HP:0001520)	1.89876732
81	Hemiparesis (HP:0001269)	1.88087376
82	Male pseudohermaphroditism (HP:0000037)	1.84621161
83	3-Methylglutaconic aciduria (HP:0003535)	1.80224378
84	Anencephaly (HP:0002323)	1.79928584
85	Short foot (HP:0001773)	1.78999782
86	Postaxial hand polydactyly (HP:0001162)	1.78138567
87	Polyuria (HP:0000103)	1.77778416
88	Methylmalonic acidemia (HP:0002912)	1.76965491
89	Generalized hypopigmentation of hair (HP:0011358)	1.76726001
90	Tubulointerstitial nephritis (HP:0001970)	1.76284609
91	Focal motor seizures (HP:0011153)	1.75097896
92	Prostate neoplasm (HP:0100787)	1.74764780
93	Small hand (HP:0200055)	1.74436122
94	Severe visual impairment (HP:0001141)	1.70924709
95	Dialeptic seizures (HP:0011146)	1.70429073
96	Absent/shortened dynein arms (HP:0200106)	1.70415216
97	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.70415216
98	Metaphyseal dysplasia (HP:0100255)	1.69767236
99	Occipital encephalocele (HP:0002085)	1.67736396
100	Hypoproteinemia (HP:0003075)	1.66397204

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.83371091
2	BMPR1B	3.09380948
3	ACVR1B	2.59973662
4	MAP4K2	2.57492358
5	ADRBK2	2.56952133
6	NUAK1	2.36240427
7	LATS1	2.36061337
8	ZAK	2.11898279
9	STK38L	2.05073483
10	CASK	2.02976217
11	WNK3	2.02576304
12	MAPK13	1.99871909
13	INSRR	1.96765818
14	PINK1	1.84188585
15	TNIK	1.84188277
16	TAOK3	1.84090478
17	TRIM28	1.74086925
18	OXSR1	1.72617449
19	STK39	1.72487702
20	MAP3K4	1.64388646
21	PIK3CG	1.59850600
22	GRK1	1.58257276
23	MKNK2	1.56951910
24	TAF1	1.49268003
25	BCR	1.43378189
26	EIF2AK3	1.17632055
27	NTRK3	1.16951611
28	ERBB3	1.11223737
29	STK3	1.10492765
30	MARK1	1.09342095
31	TEC	1.07244342
32	PRKCE	1.02263197
33	ADRBK1	0.99849674
34	PAK3	0.98803490
35	PIK3CA	0.96735167
36	MST4	0.96041963
37	PDK2	0.95672101
38	PTK2B	0.93032988
39	TLK1	0.92356107
40	PLK2	0.87536262
41	TGFBR1	0.86701370
42	FER	0.85804378
43	TXK	0.85139150
44	SIK3	0.83453093
45	MKNK1	0.80075963
46	TNK2	0.79994536
47	EPHA4	0.77819189
48	MAP2K7	0.76454600
49	PRKCG	0.75051263
50	NTRK2	0.74913875
51	DAPK2	0.72833615
52	BCKDK	0.64826889
53	MUSK	0.64773824
54	CSNK1G1	0.63686159
55	WNK4	0.61566284
56	MAP3K12	0.61415290
57	IRAK1	0.61323781
58	CSNK1A1L	0.59734402
59	BRSK2	0.59651345
60	TIE1	0.57393360
61	CAMK2A	0.55763061
62	AKT3	0.55749340
63	PKN1	0.55578901
64	NLK	0.54200735
65	CSNK1G2	0.53677129
66	NEK1	0.52159894
67	PRKAA2	0.46583029
68	CSNK1G3	0.45712072
69	FGFR2	0.44977575
70	PHKG2	0.43726518
71	PHKG1	0.43726518
72	MARK3	0.41872442
73	PRKCQ	0.41806566
74	CSNK1D	0.40412772
75	ITK	0.38458346
76	PLK3	0.37992111
77	PRKACA	0.37126745
78	CAMKK2	0.36930748
79	ABL1	0.36438401
80	PLK4	0.35699303
81	VRK1	0.34485932
82	GRK5	0.34467232
83	OBSCN	0.34185574
84	PRKACB	0.33140420
85	PRKAA1	0.32999932
86	STK38	0.32808056
87	MINK1	0.32347053
88	IKBKB	0.31317255
89	CSNK1A1	0.30697440
90	MYLK	0.30687385
91	DYRK1A	0.30063026
92	PRKG1	0.30032447
93	DYRK2	0.29605008
94	MAP2K1	0.29006763
95	ATM	0.28687841
96	PRKCA	0.28678067
97	STK11	0.26526020
98	TRPM7	0.26514335
99	IGF1R	0.26381537
100	PRKCB	0.24447021

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.29152957
2	Phototransduction_Homo sapiens_hsa04744	2.99465893
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.38212979
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.36960077
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34834165
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.32533318
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.29258637
8	ABC transporters_Homo sapiens_hsa02010	2.21602823
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.21587620
10	Nicotine addiction_Homo sapiens_hsa05033	2.17090256
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.06383911
12	Tryptophan metabolism_Homo sapiens_hsa00380	2.02771254
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.98902587
14	Homologous recombination_Homo sapiens_hsa03440	1.98625060
15	Taste transduction_Homo sapiens_hsa04742	1.95431607
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.90046785
17	Olfactory transduction_Homo sapiens_hsa04740	1.83918126
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.82881005
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.79887798
20	Propanoate metabolism_Homo sapiens_hsa00640	1.79297392
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78550209
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.77472023
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73586743
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.70805823
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.66972925
26	Basal transcription factors_Homo sapiens_hsa03022	1.60303644
27	Morphine addiction_Homo sapiens_hsa05032	1.49987751
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.49477893
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.43844771
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.33860390
31	Retinol metabolism_Homo sapiens_hsa00830	1.32257434
32	Histidine metabolism_Homo sapiens_hsa00340	1.28530789
33	Circadian entrainment_Homo sapiens_hsa04713	1.27578045
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.27159660
35	Caffeine metabolism_Homo sapiens_hsa00232	1.26764158
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.24847490
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.24200663
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.24094430
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.23866844
40	Serotonergic synapse_Homo sapiens_hsa04726	1.22726607
41	Sphingolipid metabolism_Homo sapiens_hsa00600	1.16768325
42	Peroxisome_Homo sapiens_hsa04146	1.16231842
43	GABAergic synapse_Homo sapiens_hsa04727	1.14087133
44	Salivary secretion_Homo sapiens_hsa04970	1.09376557
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.09206783
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.04708224
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.04641999
48	Calcium signaling pathway_Homo sapiens_hsa04020	0.99542092
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.99230500
50	Protein export_Homo sapiens_hsa03060	0.95513816
51	Glycerolipid metabolism_Homo sapiens_hsa00561	0.95351049
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94400331
53	Insulin secretion_Homo sapiens_hsa04911	0.86645850
54	Fatty acid degradation_Homo sapiens_hsa00071	0.84417325
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84060557
56	Circadian rhythm_Homo sapiens_hsa04710	0.82197192
57	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81371867
58	RNA polymerase_Homo sapiens_hsa03020	0.79583512
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78839047
60	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.77256889
61	Lysine degradation_Homo sapiens_hsa00310	0.75464502
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75320373
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.74764648
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74293348
65	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.72201339
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71694397
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.69972435
68	Long-term depression_Homo sapiens_hsa04730	0.66136285
69	Purine metabolism_Homo sapiens_hsa00230	0.65547043
70	RNA degradation_Homo sapiens_hsa03018	0.65510145
71	Regulation of autophagy_Homo sapiens_hsa04140	0.62512266
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60676415
73	Renin secretion_Homo sapiens_hsa04924	0.58999867
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.57072653
75	Sulfur metabolism_Homo sapiens_hsa00920	0.55025041
76	Metabolic pathways_Homo sapiens_hsa01100	0.54396614
77	One carbon pool by folate_Homo sapiens_hsa00670	0.54338312
78	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.53248829
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49827125
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.45231578
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44285424
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42312763
83	Cholinergic synapse_Homo sapiens_hsa04725	0.41740946
84	Pancreatic secretion_Homo sapiens_hsa04972	0.39830104
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39685733
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39458618
87	Glutathione metabolism_Homo sapiens_hsa00480	0.38286640
88	Gastric acid secretion_Homo sapiens_hsa04971	0.37939595
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.37476925
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.34922864
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31936460
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30594936
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30382013
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.30102006
95	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.29491694
96	Mineral absorption_Homo sapiens_hsa04978	0.27090421
97	PPAR signaling pathway_Homo sapiens_hsa03320	0.24801451
98	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.24399901
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.24033386
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.24006114

SULT1C2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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