SULT1C4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.90614264
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29636731
3lymphangiogenesis (GO:0001946)3.78067984
4epithelial cilium movement (GO:0003351)3.75140738
5presynaptic membrane assembly (GO:0097105)3.70507543
6platelet dense granule organization (GO:0060155)3.67042093
7somite development (GO:0061053)3.66314961
8limb bud formation (GO:0060174)3.64654132
9detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.52040451
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.51544527
11postsynaptic membrane organization (GO:0001941)3.51357800
12neuronal stem cell maintenance (GO:0097150)3.41320493
13negative regulation of transcription regulatory region DNA binding (GO:2000678)3.34426699
14heart valve formation (GO:0003188)3.30018399
15nonmotile primary cilium assembly (GO:0035058)3.27735604
16nephron tubule morphogenesis (GO:0072078)3.22137327
17nephron epithelium morphogenesis (GO:0072088)3.22137327
18cilium movement (GO:0003341)3.16915505
19gamma-aminobutyric acid transport (GO:0015812)3.14700310
20negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13482991
21presynaptic membrane organization (GO:0097090)3.13325076
22behavioral response to ethanol (GO:0048149)3.12722709
23negative regulation of mast cell activation (GO:0033004)3.08386865
24neuron fate determination (GO:0048664)3.04407094
25retinal ganglion cell axon guidance (GO:0031290)3.01892047
26cilium or flagellum-dependent cell motility (GO:0001539)2.99247163
27kidney morphogenesis (GO:0060993)2.94156702
28protein import into peroxisome matrix (GO:0016558)2.90782942
29Notch signaling involved in heart development (GO:0061314)2.88772252
30renal tubule morphogenesis (GO:0061333)2.87074731
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82931209
32L-fucose catabolic process (GO:0042355)2.81000306
33fucose catabolic process (GO:0019317)2.81000306
34L-fucose metabolic process (GO:0042354)2.81000306
35regulation of non-canonical Wnt signaling pathway (GO:2000050)2.80800386
36transmission of nerve impulse (GO:0019226)2.80799468
37pyrimidine nucleobase catabolic process (GO:0006208)2.79781343
38tryptophan catabolic process (GO:0006569)2.75328720
39indole-containing compound catabolic process (GO:0042436)2.75328720
40indolalkylamine catabolic process (GO:0046218)2.75328720
41regulation of cilium movement (GO:0003352)2.75248971
42intraciliary transport (GO:0042073)2.73915855
43otic vesicle formation (GO:0030916)2.73457063
44synaptic transmission, cholinergic (GO:0007271)2.73118541
45blood vessel maturation (GO:0001955)2.71327464
46regulation of vasculogenesis (GO:2001212)2.70733650
47atrial cardiac muscle cell action potential (GO:0086014)2.70539216
48regulation of timing of cell differentiation (GO:0048505)2.70299799
49negative regulation of telomere maintenance (GO:0032205)2.69328123
50cardiac right ventricle morphogenesis (GO:0003215)2.67961452
51indolalkylamine metabolic process (GO:0006586)2.65264775
52spinal cord development (GO:0021510)2.65194409
53axoneme assembly (GO:0035082)2.64184146
54ATP synthesis coupled proton transport (GO:0015986)2.63230467
55energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63230467
56ventricular trabecula myocardium morphogenesis (GO:0003222)2.62393708
57heart trabecula morphogenesis (GO:0061384)2.61324485
58neuron cell-cell adhesion (GO:0007158)2.60818269
59auditory behavior (GO:0031223)2.59975114
60cilium organization (GO:0044782)2.59781728
61sequestering of actin monomers (GO:0042989)2.59745975
62inner ear receptor stereocilium organization (GO:0060122)2.58984890
63intracellular protein transmembrane import (GO:0044743)2.57135240
64protein-cofactor linkage (GO:0018065)2.55724622
65radial glial cell differentiation (GO:0060019)2.55055634
66negative regulation of oligodendrocyte differentiation (GO:0048715)2.53616417
67regulation of development, heterochronic (GO:0040034)2.53261811
68cilium morphogenesis (GO:0060271)2.53245247
69dendritic spine morphogenesis (GO:0060997)2.51967354
70cilium assembly (GO:0042384)2.51923428
71cochlea development (GO:0090102)2.50797814
72protein polyglutamylation (GO:0018095)2.50401639
73* sulfation (GO:0051923)2.49645968
74head development (GO:0060322)2.48212946
75calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46888795
76response to pheromone (GO:0019236)2.46262247
77neural tube formation (GO:0001841)2.44878086
78DNA deamination (GO:0045006)2.44433425
79endothelial cell differentiation (GO:0045446)2.44020883
80lateral sprouting from an epithelium (GO:0060601)2.43739424
81vascular smooth muscle contraction (GO:0014829)2.42845252
82artery smooth muscle contraction (GO:0014824)2.41695359
83appendage development (GO:0048736)2.41319770
84limb development (GO:0060173)2.41319770
85smoothened signaling pathway (GO:0007224)2.40551351
86axon ensheathment in central nervous system (GO:0032291)2.40503816
87central nervous system myelination (GO:0022010)2.40503816
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.39187730
89tryptophan metabolic process (GO:0006568)2.38741947
90cell differentiation in spinal cord (GO:0021515)2.38415189
91auditory receptor cell stereocilium organization (GO:0060088)2.37944164
92neurotransmitter-gated ion channel clustering (GO:0072578)2.37737765
93protein localization to cilium (GO:0061512)2.34717764
94spinal cord motor neuron differentiation (GO:0021522)2.33776751
95amine catabolic process (GO:0009310)2.33369681
96cellular biogenic amine catabolic process (GO:0042402)2.33369681
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32445673
98serotonin receptor signaling pathway (GO:0007210)2.32426871
99negative regulation of protein oligomerization (GO:0032460)2.31140922
100regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.31127490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.43001592
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25908264
3ZNF274_21170338_ChIP-Seq_K562_Hela3.20199054
4GBX2_23144817_ChIP-Seq_PC3_Human3.18789860
5VDR_22108803_ChIP-Seq_LS180_Human2.95279198
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56157702
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38893877
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.34027159
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28985260
10FUS_26573619_Chip-Seq_HEK293_Human2.19802232
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18509276
12IGF1R_20145208_ChIP-Seq_DFB_Human2.15010063
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.10483098
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08004633
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00478955
16TAF15_26573619_Chip-Seq_HEK293_Human1.98650297
17EWS_26573619_Chip-Seq_HEK293_Human1.98032898
18P300_19829295_ChIP-Seq_ESCs_Human1.97997010
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.97180849
20RNF2_27304074_Chip-Seq_NSC_Mouse1.94319217
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93135038
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89975843
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80186262
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80095079
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79798070
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78954924
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76520194
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76161383
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75588230
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61637638
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60523155
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.55624727
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53324819
34REST_21632747_ChIP-Seq_MESCs_Mouse1.52944347
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51647318
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50829000
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50777452
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.50684700
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50409773
40IRF1_19129219_ChIP-ChIP_H3396_Human1.50205586
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50050449
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47782452
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47632161
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46407477
45SMAD4_21799915_ChIP-Seq_A2780_Human1.46376039
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45669162
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.44755235
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44519741
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44359559
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.43688210
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41933474
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41933474
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41476352
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.41211482
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40777528
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40142141
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38963504
58BCAT_22108803_ChIP-Seq_LS180_Human1.38776144
59AR_25329375_ChIP-Seq_VCAP_Human1.37451893
60CBP_20019798_ChIP-Seq_JUKART_Human1.37395005
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37395005
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30976690
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30043163
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29807760
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29334974
66* TCF4_22108803_ChIP-Seq_LS180_Human1.29056851
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.28580664
68STAT3_23295773_ChIP-Seq_U87_Human1.28279168
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27165420
70ER_23166858_ChIP-Seq_MCF-7_Human1.26360110
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24388314
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20072557
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20072557
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19101831
75* RUNX2_22187159_ChIP-Seq_PCA_Human1.16978597
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15487741
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14754600
78AR_21572438_ChIP-Seq_LNCaP_Human1.14490127
79* NANOG_19829295_ChIP-Seq_ESCs_Human1.14341912
80* SOX2_19829295_ChIP-Seq_ESCs_Human1.14341912
81TP53_22573176_ChIP-Seq_HFKS_Human1.13487722
82TCF4_23295773_ChIP-Seq_U87_Human1.12231420
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09643763
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08982626
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.07128049
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.07118183
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.06899462
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06249175
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05386099
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.05229894
91TAL1_26923725_Chip-Seq_HPCs_Mouse1.04362218
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03723428
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02278193
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01935663
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01809691
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01205920
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.00996274
98SMAD4_21741376_ChIP-Seq_EPCs_Human1.00873860
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00087906
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98360535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.13721520
2MP0002638_abnormal_pupillary_reflex2.85411385
3MP0000566_synostosis2.68723890
4MP0003880_abnormal_central_pattern2.63563996
5MP0004885_abnormal_endolymph2.61676535
6MP0010368_abnormal_lymphatic_system2.54031927
7MP0005167_abnormal_blood-brain_barrier2.42853445
8MP0006292_abnormal_olfactory_placode2.19590882
9MP0006276_abnormal_autonomic_nervous2.15346346
10MP0002938_white_spotting2.14308587
11MP0003011_delayed_dark_adaptation2.13689946
12MP0005551_abnormal_eye_electrophysiolog2.00021046
13MP0001879_abnormal_lymphatic_vessel1.93882762
14MP0002653_abnormal_ependyma_morphology1.91386682
15MP0005187_abnormal_penis_morphology1.89334648
16MP0004147_increased_porphyrin_level1.89115341
17MP0000778_abnormal_nervous_system1.87700257
18MP0001968_abnormal_touch/_nociception1.86400876
19MP0006072_abnormal_retinal_apoptosis1.86366348
20MP0004133_heterotaxia1.83272454
21MP0002102_abnormal_ear_morphology1.80543329
22MP0000631_abnormal_neuroendocrine_gland1.80347102
23MP0005646_abnormal_pituitary_gland1.78161540
24MP0001486_abnormal_startle_reflex1.75905570
25MP0002736_abnormal_nociception_after1.75500251
26MP0005084_abnormal_gallbladder_morpholo1.62467644
27MP0002735_abnormal_chemical_nociception1.60927823
28MP0005253_abnormal_eye_physiology1.60034040
29MP0003122_maternal_imprinting1.58518184
30MP0003787_abnormal_imprinting1.56647195
31MP0009745_abnormal_behavioral_response1.55483407
32MP0003195_calcinosis1.52313952
33MP0004142_abnormal_muscle_tone1.49896361
34MP0000372_irregular_coat_pigmentation1.47257326
35MP0001485_abnormal_pinna_reflex1.46733369
36MP0009046_muscle_twitch1.44977832
37MP0002557_abnormal_social/conspecific_i1.42201261
38MP0000026_abnormal_inner_ear1.41812858
39MP0002234_abnormal_pharynx_morphology1.41788898
40MP0002837_dystrophic_cardiac_calcinosis1.41443992
41MP0000516_abnormal_urinary_system1.39933638
42MP0005367_renal/urinary_system_phenotyp1.39933638
43MP0005171_absent_coat_pigmentation1.39406014
44MP0002572_abnormal_emotion/affect_behav1.38730734
45MP0002272_abnormal_nervous_system1.38722787
46MP0005645_abnormal_hypothalamus_physiol1.30730237
47MP0001984_abnormal_olfaction1.29580339
48MP0001986_abnormal_taste_sensitivity1.24932957
49MP0002928_abnormal_bile_duct1.21890474
50MP0003635_abnormal_synaptic_transmissio1.21775067
51MP0001970_abnormal_pain_threshold1.20208853
52MP0003121_genomic_imprinting1.17379176
53MP0001293_anophthalmia1.17023578
54MP0002282_abnormal_trachea_morphology1.16965133
55MP0002064_seizures1.16847498
56MP0000955_abnormal_spinal_cord1.15017403
57MP0008872_abnormal_physiological_respon1.12187948
58MP0002254_reproductive_system_inflammat1.12168177
59MP0008875_abnormal_xenobiotic_pharmacok1.12141609
60MP0002752_abnormal_somatic_nervous1.11861662
61MP0010030_abnormal_orbit_morphology1.11649154
62MP0005195_abnormal_posterior_eye1.11168725
63MP0004742_abnormal_vestibular_system1.09278839
64MP0002063_abnormal_learning/memory/cond1.06958005
65MP0001963_abnormal_hearing_physiology1.06482039
66MP0002733_abnormal_thermal_nociception1.05255884
67MP0002067_abnormal_sensory_capabilities1.04395101
68MP0002734_abnormal_mechanical_nocicepti1.03815774
69MP0003119_abnormal_digestive_system1.03591920
70MP0001501_abnormal_sleep_pattern1.02639501
71MP0000049_abnormal_middle_ear1.02001913
72MP0001529_abnormal_vocalization0.98132809
73MP0005391_vision/eye_phenotype0.97837201
74MP0001502_abnormal_circadian_rhythm0.96987622
75MP0000230_abnormal_systemic_arterial0.94364353
76MP0000537_abnormal_urethra_morphology0.94276544
77MP0002184_abnormal_innervation0.93616145
78MP0005595_abnormal_vascular_smooth0.92137276
79MP0002138_abnormal_hepatobiliary_system0.90166967
80MP0001324_abnormal_eye_pigmentation0.89537233
81MP0005423_abnormal_somatic_nervous0.88262909
82MP0003937_abnormal_limbs/digits/tail_de0.86168307
83MP0002882_abnormal_neuron_morphology0.85884713
84MP0002751_abnormal_autonomic_nervous0.84257494
85MP0009384_cardiac_valve_regurgitation0.83921064
86MP0002876_abnormal_thyroid_physiology0.83868013
87MP0008877_abnormal_DNA_methylation0.83710359
88MP0000647_abnormal_sebaceous_gland0.83469938
89MP0008789_abnormal_olfactory_epithelium0.82918196
90MP0003938_abnormal_ear_development0.81170238
91MP0001286_abnormal_eye_development0.80235631
92MP0002127_abnormal_cardiovascular_syste0.80180365
93MP0004145_abnormal_muscle_electrophysio0.79238608
94MP0005085_abnormal_gallbladder_physiolo0.78944017
95MP0003283_abnormal_digestive_organ0.78832290
96MP0001905_abnormal_dopamine_level0.77992497
97MP0010386_abnormal_urinary_bladder0.77770465
98MP0004085_abnormal_heartbeat0.77598216
99MP0001346_abnormal_lacrimal_gland0.77220261
100MP0004043_abnormal_pH_regulation0.76938278

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)4.42156297
2Pancreatic fibrosis (HP:0100732)4.22961193
3Pancreatic cysts (HP:0001737)4.18842509
4Hemiparesis (HP:0001269)3.90231175
5Molar tooth sign on MRI (HP:0002419)3.72504412
6Abnormality of midbrain morphology (HP:0002418)3.72504412
7Nephronophthisis (HP:0000090)3.67465449
8Congenital stationary night blindness (HP:0007642)3.49134012
9Abnormality of the renal medulla (HP:0100957)3.26059411
10Type II lissencephaly (HP:0007260)3.23876747
11Polydipsia (HP:0001959)2.97410895
12Abnormal drinking behavior (HP:0030082)2.97410895
13Medial flaring of the eyebrow (HP:0010747)2.91755956
14Cystic liver disease (HP:0006706)2.71737297
15Aplasia/Hypoplasia of the tibia (HP:0005772)2.61857134
16Aplasia/Hypoplasia of the spleen (HP:0010451)2.60204719
17Sclerocornea (HP:0000647)2.60021693
18Polyphagia (HP:0002591)2.59809873
19Gait imbalance (HP:0002141)2.58320787
20Tubular atrophy (HP:0000092)2.57977811
21Abnormality of the renal cortex (HP:0011035)2.56996176
22Bile duct proliferation (HP:0001408)2.56954333
23Abnormal biliary tract physiology (HP:0012439)2.56954333
24Asplenia (HP:0001746)2.56773889
25Chronic hepatic failure (HP:0100626)2.56512080
26Cerebellar dysplasia (HP:0007033)2.55888385
27Polyuria (HP:0000103)2.55501828
28Congenital, generalized hypertrichosis (HP:0004540)2.47169488
29Focal motor seizures (HP:0011153)2.46679691
30Lissencephaly (HP:0001339)2.45692377
31Anencephaly (HP:0002323)2.44895502
32Congenital primary aphakia (HP:0007707)2.44750679
33Short tibia (HP:0005736)2.43896859
34Occipital encephalocele (HP:0002085)2.39464801
35Congenital hepatic fibrosis (HP:0002612)2.38115997
36Genital tract atresia (HP:0001827)2.36718536
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.31464351
38Abnormality of the labia minora (HP:0012880)2.29359020
39Vaginal atresia (HP:0000148)2.28918164
40Supernumerary spleens (HP:0009799)2.27538319
41Anophthalmia (HP:0000528)2.22342425
42Hyperventilation (HP:0002883)2.22087542
43Nephrogenic diabetes insipidus (HP:0009806)2.20361186
44Abnormal urine output (HP:0012590)2.17300868
45Postaxial foot polydactyly (HP:0001830)2.16852088
46Abolished electroretinogram (ERG) (HP:0000550)2.16844628
47Decreased central vision (HP:0007663)2.15729500
48Male pseudohermaphroditism (HP:0000037)2.15613203
49Hypomagnesemia (HP:0002917)2.11802510
50Abnormal rod and cone electroretinograms (HP:0008323)2.11711775
51Septo-optic dysplasia (HP:0100842)2.10072463
52Optic nerve hypoplasia (HP:0000609)2.09177606
53Increased corneal curvature (HP:0100692)2.08353697
54Keratoconus (HP:0000563)2.08353697
55Anterior segment dysgenesis (HP:0007700)2.08212253
56Brushfield spots (HP:0001088)2.02710719
57Atonic seizures (HP:0010819)2.02226314
58Hemiplegia (HP:0002301)2.02131053
59Pachygyria (HP:0001302)2.01187862
60Febrile seizures (HP:0002373)2.01043206
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.99819773
62Abnormal respiratory motile cilium morphology (HP:0005938)1.99677522
63Abnormal respiratory epithelium morphology (HP:0012253)1.99677522
64Attenuation of retinal blood vessels (HP:0007843)1.99605791
65Pendular nystagmus (HP:0012043)1.97201139
66Abnormal ciliary motility (HP:0012262)1.96052369
67Intestinal atresia (HP:0011100)1.95485041
68Postaxial hand polydactyly (HP:0001162)1.94844155
69Thyroid-stimulating hormone excess (HP:0002925)1.91958292
70Specific learning disability (HP:0001328)1.90600221
713-Methylglutaconic aciduria (HP:0003535)1.90310068
72Dyskinesia (HP:0100660)1.89823142
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89544818
74Bilateral microphthalmos (HP:0007633)1.87720487
75Furrowed tongue (HP:0000221)1.85534114
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81976660
77Stenosis of the external auditory canal (HP:0000402)1.79949573
78Retinal dysplasia (HP:0007973)1.79793192
79Abnormal respiratory motile cilium physiology (HP:0012261)1.78169585
80Focal seizures (HP:0007359)1.78000858
81Gastrointestinal atresia (HP:0002589)1.77372651
82Stomach cancer (HP:0012126)1.76696739
83Preaxial hand polydactyly (HP:0001177)1.76552809
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.75779175
85Absent/shortened dynein arms (HP:0200106)1.75779175
86Acute necrotizing encephalopathy (HP:0006965)1.74249825
87Abnormality of renal excretion (HP:0011036)1.73835924
88Chorioretinal atrophy (HP:0000533)1.72280964
89Oligodactyly (hands) (HP:0001180)1.71504044
90Large for gestational age (HP:0001520)1.70630049
91Congenital sensorineural hearing impairment (HP:0008527)1.70247626
92Delayed CNS myelination (HP:0002188)1.70055006
93Mitochondrial inheritance (HP:0001427)1.69457990
94Narrow forehead (HP:0000341)1.68252025
95Dandy-Walker malformation (HP:0001305)1.67575813
96Confusion (HP:0001289)1.67016165
97Abnormal number of erythroid precursors (HP:0012131)1.66906607
98Adactyly (HP:0009776)1.66740417
99Poor coordination (HP:0002370)1.66354192
100Abnormality of the ischium (HP:0003174)1.65027568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.49773864
2PNCK3.41129830
3MAPK153.07437873
4FRK2.82920878
5BMPR1B2.77369518
6WNK32.56428923
7WNK42.44170726
8ADRBK22.41620447
9PINK12.39271488
10TIE12.36180912
11STK392.34944223
12GRK12.10773267
13NTRK21.88137081
14MAPK131.86886995
15MAP4K21.84131959
16MARK11.83614779
17CASK1.75996496
18TNIK1.74449864
19NUAK11.73228708
20EPHA41.62935922
21TLK11.61888602
22WEE11.55492537
23PASK1.54099820
24DYRK21.53815013
25KDR1.53178573
26TSSK61.52231260
27VRK11.51531263
28FGFR21.48535800
29BCKDK1.47957063
30TAOK31.41156097
31ZAK1.36778583
32EPHA31.28773777
33CAMKK21.23864469
34INSRR1.17582815
35OXSR11.17458598
36TGFBR11.09335557
37CSNK1G20.97736738
38MAP3K40.96699775
39NTRK30.96289563
40PRKCG0.95296096
41STK160.95048147
42ADRBK10.91479621
43PRKD30.91204264
44PLK20.89440747
45CSNK1G10.89128314
46CAMKK10.86117466
47BCR0.85068901
48MUSK0.84618355
49PRKCE0.83856226
50CDK30.83776199
51ACVR1B0.77635534
52IRAK10.77108346
53CSNK1G30.75348692
54PAK30.74531291
55MAPKAPK50.74254597
56CSNK1A1L0.68114301
57ITK0.67809696
58MKNK20.66966530
59ERBB30.64938668
60MAP2K70.63242824
61DAPK20.61387793
62FER0.59221347
63PLK30.58516928
64PKN10.57541812
65PIK3CA0.57201102
66CAMK2A0.56793249
67DYRK1A0.56089400
68VRK20.55499605
69MKNK10.54810622
70SIK20.54321665
71STK38L0.54079270
72PTK2B0.53392997
73NLK0.52287690
74CAMK10.49985732
75CCNB10.49866172
76MINK10.49631418
77TEC0.49489607
78PRKCQ0.48689367
79CSNK1A10.48573457
80PHKG20.48045748
81PHKG10.48045748
82PRKACA0.47322032
83RPS6KA50.46703876
84CAMK1D0.44392718
85PRKG10.41927675
86CAMK1G0.39269747
87OBSCN0.38820110
88KIT0.37477858
89FLT30.34911514
90STK110.34896349
91PRKCZ0.34357211
92TRIM280.33595390
93GSK3A0.33576359
94MAP3K70.33024052
95ERBB20.29889976
96AKT30.28886697
97SGK2230.27808172
98SGK4940.27808172
99DYRK1B0.27643321
100NEK90.27571455

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.21203565
2Oxidative phosphorylation_Homo sapiens_hsa001902.61362920
3Phototransduction_Homo sapiens_hsa047442.61269206
4Nicotine addiction_Homo sapiens_hsa050332.52633179
5Nitrogen metabolism_Homo sapiens_hsa009102.40491699
6Parkinsons disease_Homo sapiens_hsa050122.34563177
7Linoleic acid metabolism_Homo sapiens_hsa005912.23041416
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21026509
9Butanoate metabolism_Homo sapiens_hsa006502.17219719
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14997188
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.94691703
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88639208
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86402470
14Cardiac muscle contraction_Homo sapiens_hsa042601.84164482
15Protein export_Homo sapiens_hsa030601.73809384
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62184906
17Taste transduction_Homo sapiens_hsa047421.61310496
18Ribosome_Homo sapiens_hsa030101.59552626
19Alzheimers disease_Homo sapiens_hsa050101.58324917
20Huntingtons disease_Homo sapiens_hsa050161.57373141
21Tryptophan metabolism_Homo sapiens_hsa003801.56564732
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54906522
23GABAergic synapse_Homo sapiens_hsa047271.53590227
24Basal cell carcinoma_Homo sapiens_hsa052171.52736368
25Morphine addiction_Homo sapiens_hsa050321.48125705
26Fanconi anemia pathway_Homo sapiens_hsa034601.47166006
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43724027
28Peroxisome_Homo sapiens_hsa041461.36045156
29Insulin secretion_Homo sapiens_hsa049111.34726234
30Steroid biosynthesis_Homo sapiens_hsa001001.34602059
31Glutamatergic synapse_Homo sapiens_hsa047241.34490576
32Ovarian steroidogenesis_Homo sapiens_hsa049131.33844679
33Circadian entrainment_Homo sapiens_hsa047131.26214274
34Homologous recombination_Homo sapiens_hsa034401.22782093
35Olfactory transduction_Homo sapiens_hsa047401.19349029
36Caffeine metabolism_Homo sapiens_hsa002321.18786236
37Ether lipid metabolism_Homo sapiens_hsa005651.18182522
38Basal transcription factors_Homo sapiens_hsa030221.18122025
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14927929
40Chemical carcinogenesis_Homo sapiens_hsa052041.14113885
41RNA polymerase_Homo sapiens_hsa030201.13768204
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.11680378
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10583542
44Hedgehog signaling pathway_Homo sapiens_hsa043401.10278696
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.09200742
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08976003
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08789431
48Arachidonic acid metabolism_Homo sapiens_hsa005901.04255942
49Propanoate metabolism_Homo sapiens_hsa006401.04070445
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03530194
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01001567
52Serotonergic synapse_Homo sapiens_hsa047260.98441687
53Axon guidance_Homo sapiens_hsa043600.97460084
54ABC transporters_Homo sapiens_hsa020100.94815142
55Salivary secretion_Homo sapiens_hsa049700.94783809
56Retinol metabolism_Homo sapiens_hsa008300.92938656
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90249895
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90162010
59Cocaine addiction_Homo sapiens_hsa050300.88668894
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87531654
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86372976
62Bile secretion_Homo sapiens_hsa049760.85944609
63Dorso-ventral axis formation_Homo sapiens_hsa043200.82288884
64RNA degradation_Homo sapiens_hsa030180.80893529
65Regulation of autophagy_Homo sapiens_hsa041400.77216067
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74536549
67Glycerolipid metabolism_Homo sapiens_hsa005610.72417774
68Fatty acid elongation_Homo sapiens_hsa000620.70506062
69Calcium signaling pathway_Homo sapiens_hsa040200.70481119
70cAMP signaling pathway_Homo sapiens_hsa040240.64527932
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64220374
72Purine metabolism_Homo sapiens_hsa002300.63485167
73Fat digestion and absorption_Homo sapiens_hsa049750.62862911
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62057832
75Amphetamine addiction_Homo sapiens_hsa050310.61161655
76Sulfur relay system_Homo sapiens_hsa041220.56324408
77Oxytocin signaling pathway_Homo sapiens_hsa049210.53596519
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.52759837
79Selenocompound metabolism_Homo sapiens_hsa004500.52223667
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50776615
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49446855
82Metabolic pathways_Homo sapiens_hsa011000.48656291
83Mineral absorption_Homo sapiens_hsa049780.47588952
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47237207
85Dopaminergic synapse_Homo sapiens_hsa047280.47008110
86beta-Alanine metabolism_Homo sapiens_hsa004100.46411650
87Hippo signaling pathway_Homo sapiens_hsa043900.45146111
88Wnt signaling pathway_Homo sapiens_hsa043100.44484906
89Gastric acid secretion_Homo sapiens_hsa049710.43514799
90Renin secretion_Homo sapiens_hsa049240.43305997
91Long-term depression_Homo sapiens_hsa047300.42737650
92Cholinergic synapse_Homo sapiens_hsa047250.41912147
93Vitamin digestion and absorption_Homo sapiens_hsa049770.41103182
94Collecting duct acid secretion_Homo sapiens_hsa049660.40969907
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39720142
96One carbon pool by folate_Homo sapiens_hsa006700.39602843
97Fatty acid degradation_Homo sapiens_hsa000710.37086708
98Thyroid hormone synthesis_Homo sapiens_hsa049180.36918260
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36745070
100Fatty acid metabolism_Homo sapiens_hsa012120.34023683

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