SULT1E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1uronic acid metabolic process (GO:0006063)9.72999317
2glucuronate metabolic process (GO:0019585)9.72999317
3cellular glucuronidation (GO:0052695)9.68290848
4glutathione derivative biosynthetic process (GO:1901687)5.84093093
5glutathione derivative metabolic process (GO:1901685)5.84093093
6benzene-containing compound metabolic process (GO:0042537)5.74741777
7receptor recycling (GO:0001881)5.64843601
8regulation of cholesterol esterification (GO:0010872)5.52507621
9epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.51867572
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.43200926
11cardiac right ventricle morphogenesis (GO:0003215)5.42442885
12one-carbon compound transport (GO:0019755)5.34875596
13renal absorption (GO:0070293)5.33301345
14regulation of cholesterol biosynthetic process (GO:0045540)5.10676581
15glutathione metabolic process (GO:0006749)4.94050808
16high-density lipoprotein particle remodeling (GO:0034375)4.92673252
17cardiac epithelial to mesenchymal transition (GO:0060317)4.59530963
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.48433021
19keratinocyte development (GO:0003334)4.46770041
20negative regulation of transcription regulatory region DNA binding (GO:2000678)4.39206713
21L-phenylalanine catabolic process (GO:0006559)4.37104858
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.37104858
23mesenchymal cell proliferation (GO:0010463)4.37030964
24phospholipid efflux (GO:0033700)4.33666673
25doxorubicin metabolic process (GO:0044598)4.33558368
26daunorubicin metabolic process (GO:0044597)4.33558368
27polyketide metabolic process (GO:0030638)4.33558368
28reverse cholesterol transport (GO:0043691)4.30550229
29sulfur amino acid catabolic process (GO:0000098)4.27576446
30negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.22537397
31low-density lipoprotein particle remodeling (GO:0034374)4.22404020
32L-ascorbic acid metabolic process (GO:0019852)4.14802668
33regulation of skeletal muscle contraction (GO:0014819)4.13926213
34hormone catabolic process (GO:0042447)4.12353580
35limb bud formation (GO:0060174)4.10997600
36phospholipid homeostasis (GO:0055091)4.07752150
37regulation of superoxide anion generation (GO:0032928)4.07294779
38positive regulation of steroid biosynthetic process (GO:0010893)4.04507986
39cartilage morphogenesis (GO:0060536)4.00900604
40protein localization to cilium (GO:0061512)4.00616169
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.99712487
42L-phenylalanine metabolic process (GO:0006558)3.99712487
43regulation of mesenchymal cell apoptotic process (GO:2001053)3.99330287
44gland morphogenesis (GO:0022612)3.98854674
45interferon-gamma secretion (GO:0072643)3.96695634
46positive regulation of steroid metabolic process (GO:0045940)3.94921638
47regulation of transforming growth factor beta2 production (GO:0032909)3.92015667
48thrombin receptor signaling pathway (GO:0070493)3.91756730
49negative regulation of lipase activity (GO:0060192)3.91640183
50cGMP metabolic process (GO:0046068)3.88559435
51lung lobe morphogenesis (GO:0060463)3.85678280
52regulation of chemokine secretion (GO:0090196)3.80928021
53polyol transport (GO:0015791)3.74497984
54prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.74482837
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69664232
56cGMP biosynthetic process (GO:0006182)3.69473268
57cellular response to nicotine (GO:0071316)3.68010591
58sequestering of actin monomers (GO:0042989)3.66878978
59plasma lipoprotein particle remodeling (GO:0034369)3.64437603
60protein-lipid complex remodeling (GO:0034368)3.64437603
61macromolecular complex remodeling (GO:0034367)3.64437603
62regulation of bile acid biosynthetic process (GO:0070857)3.61107761
63positive regulation of actin filament depolymerization (GO:0030836)3.56255784
64otic vesicle formation (GO:0030916)3.56183960
65nucleotide transmembrane transport (GO:1901679)3.52433505
66embryonic retina morphogenesis in camera-type eye (GO:0060059)3.52206233
67regulation of cholesterol metabolic process (GO:0090181)3.52083775
68axonemal dynein complex assembly (GO:0070286)3.51390308
69glyoxylate metabolic process (GO:0046487)3.50700326
70regulation of cardioblast differentiation (GO:0051890)3.47982186
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.47662901
72platelet dense granule organization (GO:0060155)3.43797469
73omega-hydroxylase P450 pathway (GO:0097267)3.42319546
74dopamine biosynthetic process (GO:0042416)3.42013109
75regulation of cardioblast proliferation (GO:0003264)3.38652185
76regulation of secondary heart field cardioblast proliferation (GO:0003266)3.38652185
77aromatic amino acid family catabolic process (GO:0009074)3.38643133
78artery smooth muscle contraction (GO:0014824)3.38480859
79regulation of cytokine secretion involved in immune response (GO:0002739)3.37654601
80positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.36745391
81flavonoid metabolic process (GO:0009812)3.36366883
82pharyngeal system development (GO:0060037)3.33077127
83negative regulation of lipid storage (GO:0010888)3.31882610
84lateral sprouting from an epithelium (GO:0060601)3.29690905
85toxin transport (GO:1901998)3.27605768
86midbrain development (GO:0030901)3.26859046
87removal of superoxide radicals (GO:0019430)3.26791176
88cellular response to superoxide (GO:0071451)3.26791176
89cellular response to oxygen radical (GO:0071450)3.26791176
90prostaglandin metabolic process (GO:0006693)3.25643297
91prostanoid metabolic process (GO:0006692)3.25643297
92generation of neurons (GO:0048699)3.24246139
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.18366008
94positive regulation of sterol transport (GO:0032373)3.16940448
95positive regulation of cholesterol transport (GO:0032376)3.16940448
96ATP synthesis coupled proton transport (GO:0015986)3.16774243
97energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16774243
98regulation of cholesterol homeostasis (GO:2000188)3.16523009
99regulation of alkaline phosphatase activity (GO:0010692)3.15738254
100somatic stem cell division (GO:0048103)3.14743166
101bile acid biosynthetic process (GO:0006699)3.12739370
102negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.12458858
103cysteine metabolic process (GO:0006534)3.11984190
104negative regulation of chemokine production (GO:0032682)3.11792345
105nephron epithelium morphogenesis (GO:0072088)3.11100077
106nephron tubule morphogenesis (GO:0072078)3.11100077
107myoblast migration (GO:0051451)3.10186750
108tonic smooth muscle contraction (GO:0014820)3.08229133
109regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.08048058
110cranial suture morphogenesis (GO:0060363)3.07931595
1113-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.07322059
112* purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.07322059
113cell surface receptor signaling pathway involved in heart development (GO:0061311)3.06816810
114positive regulation of cholesterol efflux (GO:0010875)3.05705574
115catechol-containing compound biosynthetic process (GO:0009713)3.04873541
116catecholamine biosynthetic process (GO:0042423)3.04873541
117* xenobiotic metabolic process (GO:0006805)3.03909922
118energy homeostasis (GO:0097009)3.02413926
119cholesterol efflux (GO:0033344)3.01559073
120aldehyde catabolic process (GO:0046185)3.01260620
121androgen biosynthetic process (GO:0006702)3.00206243
122prostate gland growth (GO:0060736)3.00018966
123epoxygenase P450 pathway (GO:0019373)2.98857806
124cardiovascular system development (GO:0072358)2.98299897
125negative regulation of oligodendrocyte differentiation (GO:0048715)2.97249694
126organ growth (GO:0035265)2.97049625
127neuron fate determination (GO:0048664)2.96773920
128drug catabolic process (GO:0042737)2.96035999
129branch elongation of an epithelium (GO:0060602)2.94773480
130acute-phase response (GO:0006953)2.90344012
131sulfate transmembrane transport (GO:1902358)2.87064612
132positive regulation of meiosis (GO:0045836)2.86219263
133positive regulation of meiotic cell cycle (GO:0051446)2.82962379
134smooth muscle tissue development (GO:0048745)2.81619335
135relaxation of cardiac muscle (GO:0055119)2.81311803
136regulation of superoxide metabolic process (GO:0090322)2.81171860
137tyrosine metabolic process (GO:0006570)2.80012980
138epithelial cilium movement (GO:0003351)2.76932563
139positive regulation of blood coagulation (GO:0030194)2.76471432
140positive regulation of hemostasis (GO:1900048)2.76471432
141somite development (GO:0061053)2.76006584
142amyloid precursor protein catabolic process (GO:0042987)2.75926454
143desmosome organization (GO:0002934)2.75893252
144alpha-linolenic acid metabolic process (GO:0036109)2.74657429
145positive regulation of pseudopodium assembly (GO:0031274)2.73574823
146head development (GO:0060322)2.73459611
147cardiac ventricle morphogenesis (GO:0003208)2.72488603
148surfactant homeostasis (GO:0043129)2.71728232
149aminoglycoside antibiotic metabolic process (GO:0030647)2.69704027
150glomerulus development (GO:0032835)2.69643818
151negative regulation of fibrinolysis (GO:0051918)2.68301224
152bile acid metabolic process (GO:0008206)2.67609646
153synaptic transmission, cholinergic (GO:0007271)2.67006365
154kidney morphogenesis (GO:0060993)2.66317704
155tryptophan catabolic process (GO:0006569)2.66100770
156indole-containing compound catabolic process (GO:0042436)2.66100770
157indolalkylamine catabolic process (GO:0046218)2.66100770
158myoblast fusion (GO:0007520)2.65805671
159renal tubule morphogenesis (GO:0061333)2.65474488
160bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65243287
161positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.64744371
162embryonic body morphogenesis (GO:0010172)2.64709584
163collagen fibril organization (GO:0030199)2.62387395
164polyamine biosynthetic process (GO:0006596)2.61260975
165anterograde synaptic vesicle transport (GO:0048490)2.58506004
166organic cation transport (GO:0015695)2.58394175
167positive regulation of canonical Wnt signaling pathway (GO:0090263)2.58356918
168regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.57668200
169face morphogenesis (GO:0060325)2.55461717
170cyclic nucleotide catabolic process (GO:0009214)2.52642656
171embryonic digestive tract morphogenesis (GO:0048557)2.51118299
172retina layer formation (GO:0010842)2.50246134
173cardiac chamber morphogenesis (GO:0003206)2.45703705
174DNA integration (GO:0015074)2.43860471
175intraciliary transport (GO:0042073)2.42779690
176establishment of tissue polarity (GO:0007164)2.41704120
177establishment of planar polarity (GO:0001736)2.41704120
178Notch signaling involved in heart development (GO:0061314)2.40706995
179mesenchymal cell development (GO:0014031)2.39499150
180cell differentiation involved in metanephros development (GO:0072202)2.39062407
181toxin metabolic process (GO:0009404)2.38989786
182pathway-restricted SMAD protein phosphorylation (GO:0060389)2.35707596
183positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.35363278
184signal transduction involved in regulation of gene expression (GO:0023019)2.34236789
185positive regulation of signal transduction by p53 class mediator (GO:1901798)2.33893559
186axis elongation (GO:0003401)2.33700342
187pyrimidine dimer repair (GO:0006290)2.33433598
188sympathetic nervous system development (GO:0048485)2.33385604
189regulation of smooth muscle cell differentiation (GO:0051150)2.33254253
190response to nitrosative stress (GO:0051409)11.7908073
191xenobiotic catabolic process (GO:0042178)11.0017120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.47160888
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.31155989
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.97604626
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.89903069
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.79763821
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.73568402
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.70198834
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.47953328
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.34119721
10CLOCK_20551151_ChIP-Seq_293T_Human3.04221596
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.83389707
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.68322606
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.55109417
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.52668727
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.52418097
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.45830043
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.39938644
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.36712828
19VDR_22108803_ChIP-Seq_LS180_Human2.31455535
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.25883251
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24885087
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.22170226
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19783917
24GBX2_23144817_ChIP-Seq_PC3_Human2.17801416
25ZNF274_21170338_ChIP-Seq_K562_Hela2.02978994
26EWS_26573619_Chip-Seq_HEK293_Human2.02940106
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97745625
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96149052
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89049709
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86799452
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86434407
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86434407
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86097618
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84633580
35P300_19829295_ChIP-Seq_ESCs_Human1.83427275
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82991484
37RNF2_27304074_Chip-Seq_NSC_Mouse1.81021530
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81010175
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78164990
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74391662
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74156212
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74156212
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.72284234
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70046102
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69848720
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69848720
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.69096386
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.67673614
49* AR_25329375_ChIP-Seq_VCAP_Human1.67349934
50ZNF263_19887448_ChIP-Seq_K562_Human1.66095321
51TAF15_26573619_Chip-Seq_HEK293_Human1.63567810
52TP53_16413492_ChIP-PET_HCT116_Human1.63214737
53SMAD4_21799915_ChIP-Seq_A2780_Human1.61063398
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58371503
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55408246
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50906716
57AR_21572438_ChIP-Seq_LNCaP_Human1.49471641
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49317969
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.48092518
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47680578
61TP53_18474530_ChIP-ChIP_U2OS_Human1.44968417
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.44290896
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43278835
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43131938
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41775788
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40616960
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40467604
68ESR1_20079471_ChIP-ChIP_T-47D_Human1.40210108
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38466816
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.36415532
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35792660
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33994110
73EZH2_22144423_ChIP-Seq_EOC_Human1.33887685
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32636805
75SOX2_20726797_ChIP-Seq_SW620_Human1.31626128
76* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29890757
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29859671
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27564973
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27481965
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26869890
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26869890
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.25095781
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.23816683
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23561151
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23031343
86ER_23166858_ChIP-Seq_MCF-7_Human1.22911494
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22731552
88AHR_22903824_ChIP-Seq_MCF-7_Human1.22625350
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22169818
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21810669
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21272675
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21082486
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20869083
94RUNX2_22187159_ChIP-Seq_PCA_Human1.20702841
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20205777
96BCAT_22108803_ChIP-Seq_LS180_Human1.19616466
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19578519
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19500220
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18659351
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18321570
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.17465930
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15495068
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15437850
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15177201
105CJUN_26792858_Chip-Seq_BT549_Human1.13722761
106TCF4_23295773_ChIP-Seq_U87_Human1.12888673
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11707655
108SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11256351
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11206986
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10955517
111AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10385308
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.10094426
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09231179
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08005935
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.07953984
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05941853
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05380294
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05108320
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.03919537
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.02848202
121GATA3_24758297_ChIP-Seq_MCF-7_Human1.02673530
122IGF1R_20145208_ChIP-Seq_DFB_Human1.01284243
123* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99279119
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99005820
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.98456634
126CDX2_22108803_ChIP-Seq_LS180_Human0.98409271
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.97909851
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.97756888
129SALL4_22934838_ChIP-ChIP_CD34+_Human0.97219583
130STAT3_23295773_ChIP-Seq_U87_Human0.97072159
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96718547
132GATA4_25053715_ChIP-Seq_YYC3_Human0.95270686
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93700696
134* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91513454
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.91443633
136KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91286781
137KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91286781
138KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91286781
139SMAD_19615063_ChIP-ChIP_OVARY_Human0.90430759
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89615170
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89319651
142GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87390476
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.86158496
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85026999
145KLF5_25053715_ChIP-Seq_YYC3_Human0.84979975
146RXR_22108803_ChIP-Seq_LS180_Human0.83077491
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82515918
148RUNX_20019798_ChIP-Seq_JUKART_Human0.82077982
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81367128
150TP63_23658742_ChIP-Seq_EP156T_Human0.80942784
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.80842925
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80603582
153GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80548186
154TCF4_22108803_ChIP-Seq_LS180_Human0.80331126
155TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79846089
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79340588
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79128333
158SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78673695
159TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76783857
160* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74613940
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74554317
162SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.71253631
163CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71053387
164CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71033827
165EED_16625203_ChIP-ChIP_MESCs_Mouse0.71022042
166GATA6_25053715_ChIP-Seq_YYC3_Human0.70935608
167RING1B_27294783_Chip-Seq_NPCs_Mouse0.67665910
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67264942
169FUS_26573619_Chip-Seq_HEK293_Human0.66475843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.19234135
2MP0008789_abnormal_olfactory_epithelium5.02884351
3MP0010030_abnormal_orbit_morphology4.92663967
4MP0005171_absent_coat_pigmentation4.74259827
5MP0005394_taste/olfaction_phenotype4.55838702
6MP0005499_abnormal_olfactory_system4.55838702
7MP0005085_abnormal_gallbladder_physiolo4.23487223
8MP0001346_abnormal_lacrimal_gland3.91435961
9MP0005365_abnormal_bile_salt3.89380105
10MP0009840_abnormal_foam_cell3.65717954
11MP0005503_abnormal_tendon_morphology3.56481600
12MP0005083_abnormal_biliary_tract3.34491001
13MP0003806_abnormal_nucleotide_metabolis3.09687358
14MP0002139_abnormal_hepatobiliary_system2.90821822
15MP0002877_abnormal_melanocyte_morpholog2.76325842
16MP0010368_abnormal_lymphatic_system2.71253471
17MP0000579_abnormal_nail_morphology2.55957804
18MP0002254_reproductive_system_inflammat2.55282981
19MP0003191_abnormal_cellular_cholesterol2.44961408
20MP0003279_aneurysm2.38031789
21MP0005360_urolithiasis2.35194600
22MP0002282_abnormal_trachea_morphology2.17925788
23MP0003186_abnormal_redox_activity2.17007564
24MP0000678_abnormal_parathyroid_gland2.10697336
25MP0000762_abnormal_tongue_morphology2.07403795
26MP0000566_synostosis2.01365229
27MP0008438_abnormal_cutaneous_collagen2.00471215
28MP0000631_abnormal_neuroendocrine_gland1.94907536
29MP0010329_abnormal_lipoprotein_level1.86372393
30MP0004272_abnormal_basement_membrane1.82668158
31MP0001984_abnormal_olfaction1.77929750
32MP0002009_preneoplasia1.76756359
33MP0002108_abnormal_muscle_morphology1.69290579
34MP0005646_abnormal_pituitary_gland1.68791151
35MP0004142_abnormal_muscle_tone1.66883016
36MP0002233_abnormal_nose_morphology1.65858593
37MP0009780_abnormal_chondrocyte_physiolo1.64500990
38MP0009379_abnormal_foot_pigmentation1.58854039
39MP0001324_abnormal_eye_pigmentation1.50653091
40MP0002697_abnormal_eye_size1.48530474
41MP0008872_abnormal_physiological_respon1.46378382
42MP0002928_abnormal_bile_duct1.46319074
43MP0008057_abnormal_DNA_replication1.45288899
44MP0004043_abnormal_pH_regulation1.44446176
45MP0004019_abnormal_vitamin_homeostasis1.41676160
46MP0005174_abnormal_tail_pigmentation1.40566553
47MP0001177_atelectasis1.40443180
48MP0000639_abnormal_adrenal_gland1.38593553
49MP0002138_abnormal_hepatobiliary_system1.34980798
50MP0005595_abnormal_vascular_smooth1.33958494
51MP0000372_irregular_coat_pigmentation1.32242142
52MP0009053_abnormal_anal_canal1.31667156
53MP0005275_abnormal_skin_tensile1.30664566
54MP0005248_abnormal_Harderian_gland1.29710238
55MP0005410_abnormal_fertilization1.26039150
56MP0003690_abnormal_glial_cell1.24612937
57MP0005257_abnormal_intraocular_pressure1.22346818
58MP0004134_abnormal_chest_morphology1.21301061
59MP0005645_abnormal_hypothalamus_physiol1.19908561
60MP0000516_abnormal_urinary_system1.18487343
61MP0005367_renal/urinary_system_phenotyp1.18487343
62MP0000613_abnormal_salivary_gland1.17982552
63MP0002938_white_spotting1.17751913
64MP0006054_spinal_hemorrhage1.16509823
65MP0005332_abnormal_amino_acid1.16322725
66MP0003935_abnormal_craniofacial_develop1.15518898
67MP0001286_abnormal_eye_development1.13887486
68MP0000383_abnormal_hair_follicle1.13132140
69MP0005551_abnormal_eye_electrophysiolog1.12744820
70MP0001968_abnormal_touch/_nociception1.12652195
71MP0000049_abnormal_middle_ear1.12405750
72MP0002249_abnormal_larynx_morphology1.12330112
73MP0001299_abnormal_eye_distance/1.12021787
74MP0005508_abnormal_skeleton_morphology1.09630601
75MP0003195_calcinosis1.09042933
76MP0000230_abnormal_systemic_arterial1.06457412
77MP0000462_abnormal_digestive_system1.05885632
78MP0005187_abnormal_penis_morphology1.03563911
79MP0005408_hypopigmentation1.02536281
80MP0002932_abnormal_joint_morphology1.02238985
81MP0002277_abnormal_respiratory_mucosa1.00473989
82MP0000026_abnormal_inner_ear0.99135467
83MP0005423_abnormal_somatic_nervous0.98939560
84MP0002109_abnormal_limb_morphology0.98770282
85MP0002132_abnormal_respiratory_system0.97937988
86MP0003252_abnormal_bile_duct0.96580186
87MP0000467_abnormal_esophagus_morphology0.95675929
88MP0005377_hearing/vestibular/ear_phenot0.95429852
89MP0003878_abnormal_ear_physiology0.95429852
90MP0002135_abnormal_kidney_morphology0.94753693
91MP0005451_abnormal_body_composition0.94112775
92MP0000767_abnormal_smooth_muscle0.93610784
93MP0006292_abnormal_olfactory_placode0.93280110
94MP0001486_abnormal_startle_reflex0.92752779
95MP0000534_abnormal_ureter_morphology0.92434315
96MP0003075_altered_response_to0.92053892
97MP0008995_early_reproductive_senescence0.90727469
98MP0009250_abnormal_appendicular_skeleto0.89349197
99MP0008775_abnormal_heart_ventricle0.89132303
100MP0002396_abnormal_hematopoietic_system0.87860653
101MP0005084_abnormal_gallbladder_morpholo0.87323615
102MP0003941_abnormal_skin_development0.87236065
103MP0002653_abnormal_ependyma_morphology0.86710051
104MP0000015_abnormal_ear_pigmentation0.85872949
105MP0000647_abnormal_sebaceous_gland0.84786862
106MP0002118_abnormal_lipid_homeostasis0.84678770
107MP0001501_abnormal_sleep_pattern0.84460367
108MP0002127_abnormal_cardiovascular_syste0.84285337
109MP0009745_abnormal_behavioral_response0.83244987
110MP0001666_abnormal_nutrient_absorption0.82830689
111MP0001270_distended_abdomen0.82104211
112MP0005195_abnormal_posterior_eye0.81903218
113MP0000427_abnormal_hair_cycle0.81824281
114MP0004782_abnormal_surfactant_physiolog0.81724606
115MP0002098_abnormal_vibrissa_morphology0.81724517
116MP0002116_abnormal_craniofacial_bone0.81153851
117MP0003943_abnormal_hepatobiliary_system0.80939065
118MP0002113_abnormal_skeleton_development0.80241596
119MP0002115_abnormal_skeleton_extremities0.79906369
120MP0001293_anophthalmia0.79403485
121MP0003385_abnormal_body_wall0.79218232
122MP0002295_abnormal_pulmonary_circulatio0.78731856
123MP0003638_abnormal_response/metabolism_0.78332441
124MP0000428_abnormal_craniofacial_morphol0.78262010
125MP0002060_abnormal_skin_morphology0.77817758
126MP0002133_abnormal_respiratory_system0.76745696
127MP0005388_respiratory_system_phenotype0.76745696
128MP0003938_abnormal_ear_development0.76354572
129MP0002751_abnormal_autonomic_nervous0.76100829
130MP0001853_heart_inflammation0.75111808
131MP0002735_abnormal_chemical_nociception0.74427410
132MP0002909_abnormal_adrenal_gland0.73680851
133MP0003705_abnormal_hypodermis_morpholog0.73530181
134MP0003045_fibrosis0.73388054
135MP0004085_abnormal_heartbeat0.71896907
136MP0002177_abnormal_outer_ear0.71694088
137MP0005023_abnormal_wound_healing0.69934596
138MP0003937_abnormal_limbs/digits/tail_de0.69732274
139MP0000432_abnormal_head_morphology0.69426863
140MP0009384_cardiac_valve_regurgitation0.69192816
141MP0010678_abnormal_skin_adnexa0.68951585
142MP0001485_abnormal_pinna_reflex0.68516436
143MP0000609_abnormal_liver_physiology0.68421049
144MP0001756_abnormal_urination0.68400485
145MP0002006_tumorigenesis0.66096844
146MP0005319_abnormal_enzyme/_coenzyme0.65870738
147MP0003755_abnormal_palate_morphology0.65831786
148MP0003453_abnormal_keratinocyte_physiol0.61265410
149MP0004381_abnormal_hair_follicle0.60215490
150MP0001905_abnormal_dopamine_level0.59630618
151MP0005197_abnormal_uvea_morphology0.57933948
152MP0003942_abnormal_urinary_system0.55695741
153MP0009763_increased_sensitivity_to0.54694604
154MP0005164_abnormal_response_to0.54560303
155MP0004883_abnormal_blood_vessel0.54541096
156MP0009643_abnormal_urine_homeostasis0.52081743
157MP0000537_abnormal_urethra_morphology0.50720632
158MP0001879_abnormal_lymphatic_vessel0.46274865
159MP0002234_abnormal_pharynx_morphology0.46095867
160MP0009278_abnormal_bone_marrow0.45554394
161MP0009765_abnormal_xenobiotic_induced0.45509187
162MP0003011_delayed_dark_adaptation0.45015261
163MP0003115_abnormal_respiratory_system0.44420921
164MP0003724_increased_susceptibility_to0.43820075
165MP0005166_decreased_susceptibility_to0.43071405
166MP0000163_abnormal_cartilage_morphology0.40228821
167MP0001533_abnormal_skeleton_physiology0.39538525
168MP0005584_abnormal_enzyme/coenzyme_acti0.38606508

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)7.04916432
2Concave nail (HP:0001598)6.33082191
3Arterial tortuosity (HP:0005116)5.36499732
4Lip pit (HP:0100267)5.35525094
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.28226067
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.25334391
7Vascular tortuosity (HP:0004948)4.71733278
8Keratoconus (HP:0000563)4.39638534
9Increased corneal curvature (HP:0100692)4.39638534
10Abnormal respiratory motile cilium physiology (HP:0012261)4.26978080
11Bifid scrotum (HP:0000048)4.09010089
12Rhinitis (HP:0012384)4.05569658
13Abnormality of the phalanges of the 2nd finger (HP:0009541)4.04233635
14Conjugated hyperbilirubinemia (HP:0002908)3.92612534
15Deep venous thrombosis (HP:0002625)3.68246064
16Intrahepatic cholestasis (HP:0001406)3.59445519
17Prostate neoplasm (HP:0100787)3.59300465
18Turricephaly (HP:0000262)3.58684533
19Renal tubular acidosis (HP:0001947)3.57568011
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56661866
21Aortic dissection (HP:0002647)3.55222135
22Ridged nail (HP:0001807)3.52764542
23Humeroradial synostosis (HP:0003041)3.52742251
24Synostosis involving the elbow (HP:0003938)3.52742251
25Xanthomatosis (HP:0000991)3.51809479
26Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.49090356
27Focal motor seizures (HP:0011153)3.39905489
28Pulmonary artery stenosis (HP:0004415)3.35141994
29Chronic hepatic failure (HP:0100626)3.34237634
30Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.29340329
31Abnormality of the middle phalanges of the toes (HP:0010183)3.27666316
32Aqueductal stenosis (HP:0002410)3.27482233
33Partial duplication of the phalanx of hand (HP:0009999)3.22723676
34Chronic bronchitis (HP:0004469)3.18069099
35Papilledema (HP:0001085)3.14350108
36Fibular aplasia (HP:0002990)3.13003421
37Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.12919250
38Midline defect of the nose (HP:0004122)3.12514391
39Partial duplication of thumb phalanx (HP:0009944)3.09178796
40Right ventricular cardiomyopathy (HP:0011663)2.96472850
41Abnormal ciliary motility (HP:0012262)2.96236765
42Epidermoid cyst (HP:0200040)2.93461315
43Urethral obstruction (HP:0000796)2.89476336
44Short hallux (HP:0010109)2.87001999
45Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.83795851
46Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.79147364
47Short 1st metacarpal (HP:0010034)2.79147364
48Hyperlipoproteinemia (HP:0010980)2.79113383
4911 pairs of ribs (HP:0000878)2.78887573
50Hypophosphatemic rickets (HP:0004912)2.76934808
51Soft skin (HP:0000977)2.75015252
52Fat malabsorption (HP:0002630)2.71399030
53Hypoalphalipoproteinemia (HP:0003233)2.68785172
54Hyperammonemia (HP:0001987)2.64955822
55Recurrent corneal erosions (HP:0000495)2.64655627
56Aplasia/Hypoplasia of the lens (HP:0008063)2.64390506
57Bronchomalacia (HP:0002780)2.64252235
58Vaginal atresia (HP:0000148)2.63262591
59Abnormal hemoglobin (HP:0011902)2.63104021
60Prolonged partial thromboplastin time (HP:0003645)2.63026121
61Genital tract atresia (HP:0001827)2.62836891
62Hyperglycinuria (HP:0003108)2.61329385
63Aplasia involving bones of the upper limbs (HP:0009823)2.61251417
64Aplasia of the phalanges of the hand (HP:0009802)2.61251417
65Aplasia involving bones of the extremities (HP:0009825)2.61251417
66Molar tooth sign on MRI (HP:0002419)2.59978078
67Abnormality of midbrain morphology (HP:0002418)2.59978078
68Rickets (HP:0002748)2.58556508
69Seborrheic dermatitis (HP:0001051)2.57612785
70Aplasia/Hypoplasia of the hallux (HP:0008362)2.57546996
71Abnormality of the phalanges of the 5th finger (HP:0004213)2.57455939
72Stenosis of the external auditory canal (HP:0000402)2.56988630
73Broad distal phalanx of finger (HP:0009836)2.56194457
74Hyperventilation (HP:0002883)2.55300409
75Abnormal respiratory epithelium morphology (HP:0012253)2.53772284
76Abnormal respiratory motile cilium morphology (HP:0005938)2.53772284
77Ketosis (HP:0001946)2.51479885
78Steatorrhea (HP:0002570)2.48705758
79Abnormality of serine family amino acid metabolism (HP:0010894)2.47809068
80Abnormality of glycine metabolism (HP:0010895)2.47809068
81Broad metatarsal (HP:0001783)2.45093577
82Abnormality of the 2nd finger (HP:0004100)2.44688757
83Distal lower limb muscle weakness (HP:0009053)2.42763467
84Hypobetalipoproteinemia (HP:0003563)2.41771597
85Chronic sinusitis (HP:0011109)2.41132557
86Abnormality of the 1st metacarpal (HP:0010009)2.40503102
87Abnormality of sulfur amino acid metabolism (HP:0004339)2.40064073
88Generalized aminoaciduria (HP:0002909)2.38068102
89Hypolipoproteinemia (HP:0010981)2.37889363
90Alopecia of scalp (HP:0002293)2.36628911
91True hermaphroditism (HP:0010459)2.36318990
92Abnormality of methionine metabolism (HP:0010901)2.33892969
93Anencephaly (HP:0002323)2.33533337
94Ketoacidosis (HP:0001993)2.33050717
95Mesomelia (HP:0003027)2.30166276
96Abnormal tarsal ossification (HP:0008369)2.28355135
97Tarsal synostosis (HP:0008368)2.27226258
98Aplasia of the musculature (HP:0100854)2.25049061
99Medial flaring of the eyebrow (HP:0010747)2.24367232
100Abnormality of the proximal phalanges of the hand (HP:0009834)2.22574491
101Complement deficiency (HP:0004431)2.21919314
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20334203
103Degeneration of the lateral corticospinal tracts (HP:0002314)2.20334203
104Hydroureter (HP:0000072)2.19724594
105Abnormality of the renal medulla (HP:0100957)2.18581857
106Posterior subcapsular cataract (HP:0007787)2.18326199
107Focal segmental glomerulosclerosis (HP:0000097)2.17401315
108Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17284930
109Hypoplasia of the ulna (HP:0003022)2.16923184
110Acne (HP:0001061)2.14876664
111Stillbirth (HP:0003826)2.14260069
112Short nail (HP:0001799)2.13965521
113Pancreatic cysts (HP:0001737)2.12996704
114Abnormal foot bone ossification (HP:0010675)2.12713176
115Fibular hypoplasia (HP:0003038)2.11740745
116Pili torti (HP:0003777)2.11026226
117Nephritis (HP:0000123)2.10260413
118Hyperthyroidism (HP:0000836)2.10244039
119Abnormality of the renal cortex (HP:0011035)2.09529067
120Bell-shaped thorax (HP:0001591)2.08998033
121Renal hypoplasia (HP:0000089)2.08107736
122Alveolar cell carcinoma (HP:0006519)2.07947238
123Pancreatic fibrosis (HP:0100732)2.07876627
124Hypercholesterolemia (HP:0003124)2.07746316
125Systemic lupus erythematosus (HP:0002725)2.06829191
126Abnormality of the common coagulation pathway (HP:0010990)2.06611185
127Abnormality of the labia minora (HP:0012880)2.05254046
128Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05201990
129Spondylolisthesis (HP:0003302)2.04383468
130Occipital encephalocele (HP:0002085)2.04359636
131Meningioma (HP:0002858)2.04172390
132Short tibia (HP:0005736)2.03957143
133Buphthalmos (HP:0000557)2.03261697
134Cerebral palsy (HP:0100021)2.01722955
135Synostosis involving bones of the lower limbs (HP:0009138)2.01229640
136Synostosis involving bones of the feet (HP:0009140)2.01229640
137Nephronophthisis (HP:0000090)2.00560379
138Myocardial infarction (HP:0001658)2.00227652
139Down-sloping shoulders (HP:0200021)1.97971934
140Enlarged epiphyses (HP:0010580)1.96945606
141Corneal erosion (HP:0200020)1.96722598
142Prolonged neonatal jaundice (HP:0006579)1.95898608
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.95280556
144Abnormality of the parathyroid morphology (HP:0011766)1.94959202
145Esophageal atresia (HP:0002032)1.94380725
146Stage 5 chronic kidney disease (HP:0003774)1.94293708
147Bowing of the arm (HP:0006488)1.93969609
148Bowed forearm bones (HP:0003956)1.93969609
149Intellectual disability, moderate (HP:0002342)1.93436872
150Femoral bowing (HP:0002980)1.93170782
151Hypoplastic scapulae (HP:0000882)1.92882746
152Aplasia/Hypoplasia of the scapulae (HP:0006713)1.92882746
153Cutaneous finger syndactyly (HP:0010554)1.91484052
154Hyperglycinemia (HP:0002154)1.91337624
155Pancreatitis (HP:0001733)1.90603630
156Sleep apnea (HP:0010535)1.88984442
157Abnormality of cochlea (HP:0000375)1.88703026
158Neoplasm of the tracheobronchial system (HP:0100552)1.88294430
159Abnormality of pyrimidine metabolism (HP:0004353)1.87274330
160Abnormality of the distal phalanges of the toes (HP:0010182)1.86944494
161Preauricular pit (HP:0004467)1.86462731
162Periauricular skin pits (HP:0100277)1.86462731
163Renal tubular dysfunction (HP:0000124)1.85988698
164Congenital primary aphakia (HP:0007707)1.85603468
165Cupped ear (HP:0000378)1.84492972
166Pigmentary retinal degeneration (HP:0001146)1.84151336
167Gait imbalance (HP:0002141)1.82962237
168Abnormality of complement system (HP:0005339)1.82548655
169Sparse lateral eyebrow (HP:0005338)1.82521311
170Mixed hearing impairment (HP:0000410)1.82120257
171Hypoplastic labia majora (HP:0000059)1.81110957
172Abnormality of the nasolacrimal system (HP:0000614)1.77720600
173Sparse scalp hair (HP:0002209)1.76466041
174Glomerulosclerosis (HP:0000096)1.75124585
175Nephrogenic diabetes insipidus (HP:0009806)1.75099172
176Abnormal finger flexion creases (HP:0006143)1.74579893
177Exostoses (HP:0100777)1.72177215
178Absent phalangeal crease (HP:0006109)1.71870961
179Symphalangism affecting the phalanges of the hand (HP:0009773)1.71472479
180Abnormality of the vitreous humor (HP:0004327)1.71119787
181Bilateral microphthalmos (HP:0007633)1.69958372
182Abnormality of the lacrimal duct (HP:0011481)1.69800180
183Nephrotic syndrome (HP:0000100)1.66821819
184Glomerulonephritis (HP:0000099)1.66055743
185Aplasia/Hypoplasia of the ulna (HP:0006495)1.64608139
186Aplasia/Hypoplasia of the patella (HP:0006498)1.64491191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK246.45780345
2RIPK14.48303392
3MAP3K34.09701994
4ZAK3.55940293
5PRPF4B3.21796500
6BCKDK2.88443978
7MAPK152.70768301
8ERN12.70009229
9TAOK22.37413327
10MAP3K22.31031237
11FRK2.31028465
12MAP2K32.12482132
13MAP2K22.10547062
14MST42.05272896
15RPS6KB22.04220094
16LMTK22.00885359
17PAK31.98818629
18TNIK1.78835401
19HIPK21.77447184
20TAOK11.76095952
21DDR21.74095555
22TESK11.74021365
23TGFBR11.73628713
24PBK1.72197830
25EPHB21.72060870
26SIK11.69423572
27EPHB11.63502503
28TIE11.62038011
29PNCK1.52624155
30MAP3K41.49991370
31LRRK21.43667523
32TEC1.41528258
33SGK21.41441755
34WEE11.38729067
35CLK11.38550056
36DYRK31.35768014
37WNK31.32459752
38INSRR1.31941256
39STK38L1.28243695
40MAP2K61.28206619
41MAPKAPK51.23587477
42MAP3K141.21913639
43MAP3K111.21616459
44GRK11.21610387
45IRAK31.20788048
46LATS11.15196152
47NEK61.14785612
48EPHA21.13895467
49NLK1.13034542
50FGFR21.11894445
51RPS6KA41.10957297
52SGK2231.10775668
53SGK4941.10775668
54AKT31.07714501
55MAP2K11.07015652
56VRK11.04667562
57MST1R1.02951233
58PRKG21.02671754
59BMPR1B1.02492422
60YES11.01450594
61FES0.99329984
62PIK3CG0.98856641
63CDK60.96977636
64TYK20.96794935
65SGK30.96598860
66MKNK10.95190321
67GRK70.92878418
68MAPK120.90333552
69OXSR10.87811275
70ERBB40.87418995
71DYRK1B0.87041319
72STK30.86706511
73ILK0.86216074
74TLK10.84605422
75STK390.83741771
76IRAK40.83543410
77NME10.82090268
78FGFR40.81311623
79IRAK20.79255062
80MAPK70.77984996
81CAMK40.77944135
82IRAK10.77916449
83FGFR10.77649589
84PDK20.76477722
85ADRBK10.75652680
86IKBKE0.75383316
87EPHA30.74583241
88PLK30.74449241
89KIT0.73666255
90STK40.71006283
91CHUK0.70049325
92TAF10.69385978
93ERBB20.67621508
94PLK20.67171597
95ITK0.66651983
96MAPK130.65732917
97GSK3A0.65448305
98ERBB30.65395828
99PRKCI0.64301082
100PASK0.62924920
101BRSK20.60110158
102CDK30.59902333
103PRKCE0.59473114
104TYRO30.58811544
105PRKCG0.57332730
106VRK20.57108736
107FER0.56804411
108PIK3CA0.56739706
109MAPK40.55594326
110ADRBK20.55460172
111LIMK10.54091855
112ABL20.52509888
113PDGFRA0.51104893
114MYLK0.50635130
115UHMK10.50609053
116PTK2B0.50261153
117CAMK2G0.50117120
118RPS6KA60.48266685
119MAPKAPK30.47974475
120MAPKAPK20.47716391
121CAMK10.47421795
122MAP4K20.47340579
123DAPK20.47330883
124RPS6KC10.47103210
125RPS6KL10.47103210
126NUAK10.45079922
127MAP3K100.44712275
128TRPM70.42963997
129CAMK2B0.42460668
130PRKCQ0.42411220
131PRKG10.41640548
132BMPR20.41494016
133EIF2AK20.41258692
134CCNB10.40440775
135MAP3K50.36556009
136PINK10.36324513
137IKBKB0.35176237
138WNK40.34557103
139RPS6KA20.34444495
140CAMK2D0.33363453
141CAMK2A0.32167581
142DYRK1A0.31494185
143MAP3K10.30956963
144JAK10.30798916
145PRKACA0.30658767
146TSSK60.30646343
147OBSCN0.30388267
148CASK0.30044285
149MAPK30.29926947
150PRKD10.29886863
151STK380.29100377
152MUSK0.28855221
153MAP2K40.28825670
154ROCK10.28739608
155MAPK10.28628544
156CDK80.28545389
157TTK0.27398973
158MATK0.27326215
159MKNK20.26825123
160CSNK1G10.26391846
161PRKAA10.25248581
162IGF1R0.24998763
163STK100.24487694
164AKT20.23051717
165RPS6KA50.22972787
166PDGFRB0.22579509

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000405.35083799
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000535.22549389
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009825.03761492
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.87411070
5Chemical carcinogenesis_Homo sapiens_hsa052044.40292496
6* Steroid hormone biosynthesis_Homo sapiens_hsa001403.07828866
7Phototransduction_Homo sapiens_hsa047443.05707244
8Sulfur metabolism_Homo sapiens_hsa009202.70689387
9Oxidative phosphorylation_Homo sapiens_hsa001902.69525390
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.59144579
11Glutathione metabolism_Homo sapiens_hsa004802.55000305
12ECM-receptor interaction_Homo sapiens_hsa045122.46428993
13Retinol metabolism_Homo sapiens_hsa008302.32586802
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.27967392
15Parkinsons disease_Homo sapiens_hsa050122.14388010
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10227528
17Starch and sucrose metabolism_Homo sapiens_hsa005002.08112017
18Ribosome_Homo sapiens_hsa030101.93458377
19Protein digestion and absorption_Homo sapiens_hsa049741.92185118
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.91667490
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88786809
22Cardiac muscle contraction_Homo sapiens_hsa042601.82902858
23Butanoate metabolism_Homo sapiens_hsa006501.76075501
24Alzheimers disease_Homo sapiens_hsa050101.66515088
25Linoleic acid metabolism_Homo sapiens_hsa005911.64257244
26Phenylalanine metabolism_Homo sapiens_hsa003601.59931305
27Complement and coagulation cascades_Homo sapiens_hsa046101.48057032
28Renin secretion_Homo sapiens_hsa049241.47028711
29beta-Alanine metabolism_Homo sapiens_hsa004101.38429673
30Fatty acid degradation_Homo sapiens_hsa000711.38107447
31Nitrogen metabolism_Homo sapiens_hsa009101.36297814
32Histidine metabolism_Homo sapiens_hsa003401.36027498
33Peroxisome_Homo sapiens_hsa041461.35500903
34Caffeine metabolism_Homo sapiens_hsa002321.33249402
35Huntingtons disease_Homo sapiens_hsa050161.31867758
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30834661
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30600530
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28550570
39Sulfur relay system_Homo sapiens_hsa041221.27060496
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25155479
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24978075
42Olfactory transduction_Homo sapiens_hsa047401.22769663
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22008014
44Circadian entrainment_Homo sapiens_hsa047131.20519031
45Arginine biosynthesis_Homo sapiens_hsa002201.17841096
46Tryptophan metabolism_Homo sapiens_hsa003801.16823990
47Dilated cardiomyopathy_Homo sapiens_hsa054141.15422004
48Propanoate metabolism_Homo sapiens_hsa006401.14768156
49Tyrosine metabolism_Homo sapiens_hsa003501.14109521
50PPAR signaling pathway_Homo sapiens_hsa033201.13690821
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13558467
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.12827108
53ABC transporters_Homo sapiens_hsa020101.11881993
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11338868
55Salivary secretion_Homo sapiens_hsa049701.09661208
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07439647
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05825938
58Ovarian steroidogenesis_Homo sapiens_hsa049131.04105757
59Galactose metabolism_Homo sapiens_hsa000520.99522118
60TGF-beta signaling pathway_Homo sapiens_hsa043500.99072311
61Bile secretion_Homo sapiens_hsa049760.95658323
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95066519
63Selenocompound metabolism_Homo sapiens_hsa004500.92022981
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87137956
65Amoebiasis_Homo sapiens_hsa051460.87043888
66Basal cell carcinoma_Homo sapiens_hsa052170.86968691
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84733664
68Basal transcription factors_Homo sapiens_hsa030220.82400712
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81559476
70Amphetamine addiction_Homo sapiens_hsa050310.81487889
71Fatty acid metabolism_Homo sapiens_hsa012120.79954129
72Cocaine addiction_Homo sapiens_hsa050300.76884278
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.75233309
74Folate biosynthesis_Homo sapiens_hsa007900.73575721
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71446981
76Staphylococcus aureus infection_Homo sapiens_hsa051500.70791077
77Serotonergic synapse_Homo sapiens_hsa047260.69675984
78Hippo signaling pathway_Homo sapiens_hsa043900.67328693
79Arachidonic acid metabolism_Homo sapiens_hsa005900.64597791
80Small cell lung cancer_Homo sapiens_hsa052220.64363936
81African trypanosomiasis_Homo sapiens_hsa051430.63362827
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60307084
83Sphingolipid metabolism_Homo sapiens_hsa006000.60141491
84Protein export_Homo sapiens_hsa030600.57648956
85Focal adhesion_Homo sapiens_hsa045100.53431188
86Glycerolipid metabolism_Homo sapiens_hsa005610.52143802
87Taste transduction_Homo sapiens_hsa047420.51136355
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50255587
89Ether lipid metabolism_Homo sapiens_hsa005650.49467757
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48836738
91Renin-angiotensin system_Homo sapiens_hsa046140.47397242
92Calcium signaling pathway_Homo sapiens_hsa040200.46366416
93Proteasome_Homo sapiens_hsa030500.46354465
94Prostate cancer_Homo sapiens_hsa052150.46125120
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45980017
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44931749
97Arginine and proline metabolism_Homo sapiens_hsa003300.43142960
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42985375
99Prion diseases_Homo sapiens_hsa050200.42874837
100Vitamin B6 metabolism_Homo sapiens_hsa007500.42832662
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41651879
102Pancreatic secretion_Homo sapiens_hsa049720.40345359
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39822849
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38238951
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37971766
106Melanogenesis_Homo sapiens_hsa049160.37722405
107Steroid biosynthesis_Homo sapiens_hsa001000.36992754
108Fanconi anemia pathway_Homo sapiens_hsa034600.36692985
109Notch signaling pathway_Homo sapiens_hsa043300.35666572
110Wnt signaling pathway_Homo sapiens_hsa043100.34553431
111Morphine addiction_Homo sapiens_hsa050320.34465803
112Circadian rhythm_Homo sapiens_hsa047100.33989732
113Collecting duct acid secretion_Homo sapiens_hsa049660.33364486
114Thyroid hormone synthesis_Homo sapiens_hsa049180.32902118
115Insulin resistance_Homo sapiens_hsa049310.29545006
116Biosynthesis of amino acids_Homo sapiens_hsa012300.29365270
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28998140
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.28692420
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27671571
120Pyruvate metabolism_Homo sapiens_hsa006200.27330191
121Fat digestion and absorption_Homo sapiens_hsa049750.25460402
122Fatty acid biosynthesis_Homo sapiens_hsa000610.24149112
123TNF signaling pathway_Homo sapiens_hsa046680.21685120
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.21387674
125Fatty acid elongation_Homo sapiens_hsa000620.21305934
126Adherens junction_Homo sapiens_hsa045200.19777826
127Carbon metabolism_Homo sapiens_hsa012000.17097256
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16478384
129Metabolic pathways_Homo sapiens_hsa011000.15705840
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.15498642
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.15223292
132Vitamin digestion and absorption_Homo sapiens_hsa049770.14319300
133Pertussis_Homo sapiens_hsa051330.13702804
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12134421
135Toll-like receptor signaling pathway_Homo sapiens_hsa046200.10872810
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10362351
137Lysine degradation_Homo sapiens_hsa003100.09185739
138Fructose and mannose metabolism_Homo sapiens_hsa000510.08488261
139Rheumatoid arthritis_Homo sapiens_hsa053230.08102966
140Thyroid cancer_Homo sapiens_hsa052160.07922593
141Toxoplasmosis_Homo sapiens_hsa051450.06260419
142Pentose phosphate pathway_Homo sapiens_hsa000300.05943762
143Mineral absorption_Homo sapiens_hsa049780.05781809
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.05330452
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.04733021
146Gastric acid secretion_Homo sapiens_hsa049710.02467190
147Hepatitis C_Homo sapiens_hsa051600.02400700
148Leishmaniasis_Homo sapiens_hsa051400.00513093
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00329996
150Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0335137
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0062725
152Prolactin signaling pathway_Homo sapiens_hsa04917-0.0053637
153NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0014516

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