SULT2B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.72631949
2keratinization (GO:0031424)7.89638159
3angiotensin maturation (GO:0002003)7.00370400
4establishment of skin barrier (GO:0061436)6.84251685
5intestinal absorption (GO:0050892)6.46637743
6intermediate filament organization (GO:0045109)6.44258383
7regulation of water loss via skin (GO:0033561)6.35814664
8hair cycle (GO:0042633)5.70667929
9molting cycle (GO:0042303)5.70667929
10intestinal cholesterol absorption (GO:0030299)5.59976584
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.25466538
12ectoderm development (GO:0007398)5.22555812
13keratinocyte development (GO:0003334)5.21575678
14linoleic acid metabolic process (GO:0043651)5.00911935
15lipoxygenase pathway (GO:0019372)4.86716100
16vocalization behavior (GO:0071625)4.61002054
17hemidesmosome assembly (GO:0031581)4.56145730
18positive regulation of keratinocyte differentiation (GO:0045618)4.50089318
19intestinal epithelial cell development (GO:0060576)4.46721744
20adhesion of symbiont to host cell (GO:0044650)4.27820974
21virion attachment to host cell (GO:0019062)4.27820974
22multicellular organismal water homeostasis (GO:0050891)4.27429951
23transepithelial transport (GO:0070633)4.22009926
24negative regulation of keratinocyte proliferation (GO:0010839)4.19902820
25gap junction assembly (GO:0016264)4.09506357
26phosphatidylcholine acyl-chain remodeling (GO:0036151)3.98143478
27postsynaptic membrane organization (GO:0001941)3.95456445
28actin filament depolymerization (GO:0030042)3.92950925
29response to histamine (GO:0034776)3.86306076
30keratinocyte proliferation (GO:0043616)3.83090305
31regulation of cell proliferation involved in kidney development (GO:1901722)3.81750547
32negative regulation of interferon-gamma production (GO:0032689)3.76964774
33intermediate filament cytoskeleton organization (GO:0045104)3.69484765
34water homeostasis (GO:0030104)3.69481263
35keratinocyte differentiation (GO:0030216)3.69450648
36establishment of planar polarity (GO:0001736)3.69392135
37establishment of tissue polarity (GO:0007164)3.69392135
38regulation of keratinocyte differentiation (GO:0045616)3.65935671
39fatty acid elongation (GO:0030497)3.65241497
40regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.63535749
41intermediate filament-based process (GO:0045103)3.61512589
42neurotransmitter-gated ion channel clustering (GO:0072578)3.59834110
43vitamin A metabolic process (GO:0006776)3.58697278
44digestive system process (GO:0022600)3.57719089
45transferrin transport (GO:0033572)3.57243705
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.57154016
47ceramide biosynthetic process (GO:0046513)3.54429447
48peptide hormone processing (GO:0016486)3.46658319
49phosphatidylserine metabolic process (GO:0006658)3.45760989
50detection of bacterium (GO:0016045)3.43394288
51presynaptic membrane assembly (GO:0097105)3.43331074
52drinking behavior (GO:0042756)3.39412742
53skin morphogenesis (GO:0043589)3.37669412
54cardiac right ventricle morphogenesis (GO:0003215)3.34347124
55epidermis development (GO:0008544)3.33919645
56energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.31641422
57ATP hydrolysis coupled proton transport (GO:0015991)3.31641422
58NADH metabolic process (GO:0006734)3.31424464
59ferric iron transport (GO:0015682)3.29008329
60trivalent inorganic cation transport (GO:0072512)3.29008329
61norepinephrine metabolic process (GO:0042415)3.26041759
62digestion (GO:0007586)3.25153475
63regulation of bile acid biosynthetic process (GO:0070857)3.23648450
64hair cell differentiation (GO:0035315)3.19640144
65epithelium development (GO:0060429)3.17625106
66epidermal cell differentiation (GO:0009913)3.16870741
67regulation of transforming growth factor beta1 production (GO:0032908)3.16213686
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.14664876
69nucleobase catabolic process (GO:0046113)3.12373617
70regulation of ruffle assembly (GO:1900027)3.11247938
71regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.08988130
72regulation of natural killer cell differentiation (GO:0032823)3.08226688
73sulfate transmembrane transport (GO:1902358)3.08192513
74sphingoid metabolic process (GO:0046519)3.07468028
75phosphatidylserine acyl-chain remodeling (GO:0036150)3.05871223
76GDP-mannose metabolic process (GO:0019673)3.04776671
77synaptic vesicle docking involved in exocytosis (GO:0016081)3.04182546
78polarized epithelial cell differentiation (GO:0030859)3.03737013
79positive regulation of monocyte chemotaxis (GO:0090026)3.03496283
80bicarbonate transport (GO:0015701)3.01073094
81glucosamine-containing compound catabolic process (GO:1901072)3.00377220
82peptide cross-linking (GO:0018149)3.00339175
83positive regulation of epidermis development (GO:0045684)2.98340105
84cardiac conduction (GO:0061337)2.96228780
85phosphatidylinositol acyl-chain remodeling (GO:0036149)2.91636221
86regulation of penile erection (GO:0060405)2.90339447
87presynaptic membrane organization (GO:0097090)2.89643812
88long-chain fatty acid biosynthetic process (GO:0042759)2.88670276
89protein depolymerization (GO:0051261)2.88505329
90primary alcohol catabolic process (GO:0034310)2.88367978
91phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.87420037
92positive regulation of hair follicle development (GO:0051798)2.87306817
93positive regulation of hair cycle (GO:0042635)2.87306817
94regulation of actin nucleation (GO:0051125)2.85002812
95adhesion of symbiont to host (GO:0044406)2.84700389
96ventricular cardiac muscle cell action potential (GO:0086005)2.83939417
97regulation of glutamate receptor signaling pathway (GO:1900449)2.82115052
98regulation of keratinocyte proliferation (GO:0010837)2.81923566
99hepatocyte apoptotic process (GO:0097284)2.81783817
100sphingolipid biosynthetic process (GO:0030148)2.81534855
101detection of other organism (GO:0098543)2.80168464
102regulation of chemokine secretion (GO:0090196)2.80121611
103neuron cell-cell adhesion (GO:0007158)2.79845536
104regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.79275549
105alditol phosphate metabolic process (GO:0052646)2.79009957
106regulation of heart rate by cardiac conduction (GO:0086091)2.78677674
107regulation of epidermal cell differentiation (GO:0045604)2.78498669
108diol metabolic process (GO:0034311)2.77879534
109modified amino acid transport (GO:0072337)2.77622351
110maintenance of gastrointestinal epithelium (GO:0030277)2.77102886
111phospholipid scrambling (GO:0017121)2.76343946
112epithelial cell differentiation (GO:0030855)2.71467717
113glutamate secretion (GO:0014047)2.71100267
114sulfur compound transport (GO:0072348)2.70493812
115eyelid development in camera-type eye (GO:0061029)2.69890527
116oligosaccharide catabolic process (GO:0009313)2.69481024
117one-carbon compound transport (GO:0019755)2.69454935
118epithelial cell maturation (GO:0002070)2.69305801
119sperm capacitation (GO:0048240)2.67623919
120regulation of T cell chemotaxis (GO:0010819)2.63322835
121positive regulation of T cell chemotaxis (GO:0010820)2.63322835
122regulation of epidermis development (GO:0045682)2.62713184
123regulation of synaptic vesicle exocytosis (GO:2000300)2.62096163
124phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.61772098
125phospholipid catabolic process (GO:0009395)2.61555792
126positive regulation of epidermal cell differentiation (GO:0045606)2.61487224
127retinol metabolic process (GO:0042572)2.59654813
128regulation of synaptic vesicle transport (GO:1902803)2.58952102
129synaptic vesicle exocytosis (GO:0016079)2.57756245
130positive regulation of Cdc42 GTPase activity (GO:0043089)2.57693531
131positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.57169483
132membrane lipid biosynthetic process (GO:0046467)2.56223032
133galactose catabolic process (GO:0019388)2.56197404
134oocyte development (GO:0048599)2.55882187
135vitamin transmembrane transport (GO:0035461)2.55204633
136sequestering of metal ion (GO:0051238)2.55151028
137pyrimidine-containing compound transmembrane transport (GO:0072531)2.54561941
138cell communication involved in cardiac conduction (GO:0086065)2.54007093
139phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.52995959
140L-fucose catabolic process (GO:0042355)2.52270101
141fucose catabolic process (GO:0019317)2.52270101
142L-fucose metabolic process (GO:0042354)2.52270101
143UDP-N-acetylglucosamine metabolic process (GO:0006047)2.52134881
144positive regulation of synapse maturation (GO:0090129)2.51098901
145calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.51068779
146glycerol metabolic process (GO:0006071)2.50538957
147phosphate ion homeostasis (GO:0055062)2.50307148
148trivalent inorganic anion homeostasis (GO:0072506)2.50307148
149negative regulation of dendrite morphogenesis (GO:0050774)2.50091385
150response to food (GO:0032094)2.49832588
151sulfate transport (GO:0008272)2.49338834
152defense response to fungus (GO:0050832)2.46403650
153phosphatidylglycerol metabolic process (GO:0046471)2.43496920
154regulation of Cdc42 GTPase activity (GO:0043088)2.41514574
155hair follicle morphogenesis (GO:0031069)2.37618780
156apical protein localization (GO:0045176)2.33316958
157negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.33157931
158face development (GO:0060324)2.32306622
159ear development (GO:0043583)2.31205589
160cell differentiation involved in embryonic placenta development (GO:0060706)2.27642625
161very long-chain fatty acid metabolic process (GO:0000038)2.27569238
162negative regulation of kidney development (GO:0090185)2.27257658
163surfactant homeostasis (GO:0043129)2.24159408
164epithelial cell-cell adhesion (GO:0090136)2.22854609
165axoneme assembly (GO:0035082)2.22053669
166sphingosine metabolic process (GO:0006670)2.22048634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human5.31900439
2EZH2_22144423_ChIP-Seq_EOC_Human3.96620108
3* ESR2_21235772_ChIP-Seq_MCF-7_Human3.90701254
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81362020
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.31767417
6HIF1A_21447827_ChIP-Seq_MCF-7_Human3.24727429
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97532851
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66209668
9GBX2_23144817_ChIP-Seq_PC3_Human2.54279623
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.49097981
11* GATA3_24758297_ChIP-Seq_MCF-7_Human2.23828151
12* RACK7_27058665_Chip-Seq_MCF-7_Human2.10404628
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00957170
14TP63_17297297_ChIP-ChIP_HaCaT_Human10.3426787
15SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99817273
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99154831
17* CDX2_20551321_ChIP-Seq_CACO-2_Human1.96958598
18REST_21632747_ChIP-Seq_MESCs_Mouse1.95351360
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89324903
20E2F1_20622854_ChIP-Seq_HELA_Human1.86984014
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86712258
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.86388011
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81552706
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73685715
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72924879
26VDR_22108803_ChIP-Seq_LS180_Human1.71278189
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67429078
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67280328
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.63703781
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63127134
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63127134
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62600640
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62344935
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.62058882
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60311624
36CTCF_20526341_ChIP-Seq_ESCs_Human1.60285524
37SMC4_20622854_ChIP-Seq_HELA_Human1.57304725
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56656336
39ERA_21632823_ChIP-Seq_H3396_Human1.56475722
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56037384
41P68_20966046_ChIP-Seq_HELA_Human1.50097355
42* ATF3_27146783_Chip-Seq_COLON_Human1.49914381
43ERG_20517297_ChIP-Seq_VCAP_Human1.49656476
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48979420
45BCOR_27268052_Chip-Seq_Bcells_Human1.47071691
46ELF5_23300383_ChIP-Seq_T47D_Human1.45803682
47RNF2_27304074_Chip-Seq_NSC_Mouse1.45219696
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44093588
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42849711
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.42440804
51ZNF263_19887448_ChIP-Seq_K562_Human1.41015650
52* SOX2_20726797_ChIP-Seq_SW620_Human1.40875274
53RAC3_21632823_ChIP-Seq_H3396_Human1.40295619
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39921237
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38439589
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37965811
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36864814
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36864814
59P53_21459846_ChIP-Seq_SAOS-2_Human1.36116444
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.36102805
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.35766073
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.35205506
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34318989
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.32593136
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32514498
66CTCF_27219007_Chip-Seq_Bcells_Human1.32312800
67KLF5_25053715_ChIP-Seq_YYC3_Human1.31480973
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29156915
69BCL6_27268052_Chip-Seq_Bcells_Human1.26763951
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24196827
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23755188
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.23265838
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.23263058
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23242404
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.22504172
76OCT4_20526341_ChIP-Seq_ESCs_Human1.22376858
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22179688
78RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21856663
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.21779586
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21085517
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18317766
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17103787
83DROSHA_22980978_ChIP-Seq_HELA_Human1.16832256
84RXR_22108803_ChIP-Seq_LS180_Human1.16249185
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14304220
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14065066
87AHR_22903824_ChIP-Seq_MCF-7_Human1.13659355
88* HOXB7_26014856_ChIP-Seq_BT474_Human1.12448943
89* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11639031
90P300_27268052_Chip-Seq_Bcells_Human1.11626479
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09953686
92TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09440440
93PHF8_20622854_ChIP-Seq_HELA_Human1.08095131
94FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05173569
95AR_20517297_ChIP-Seq_VCAP_Human1.04287495
96TP63_23658742_ChIP-Seq_EP156T_Human1.03134585
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02101493
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01433566
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.01306901
100* GATA4_25053715_ChIP-Seq_YYC3_Human1.00972324
101AR_25329375_ChIP-Seq_VCAP_Human1.00838170
102GATA6_21074721_ChIP-Seq_CACO-2_Human1.00825542
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00606796
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99667541
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.99278642
106NCOR_22424771_ChIP-Seq_293T_Human0.99178601
107LXR_22292898_ChIP-Seq_THP-1_Human0.98778332
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98033684
109FOXH1_21741376_ChIP-Seq_ESCs_Human0.97012411
110PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96801186
111CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96572431
112GATA3_21878914_ChIP-Seq_MCF-7_Human0.95904948
113SA1_27219007_Chip-Seq_Bcells_Human0.95689617
114AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95303484
115FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94787511
116FOXA1_25329375_ChIP-Seq_VCAP_Human0.94787511
117CREB1_26743006_Chip-Seq_LNCaP_Human0.94750891
118EGR1_19032775_ChIP-ChIP_M12_Human0.94595881
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94428402
120RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94012554
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93831552
122NANOG_20526341_ChIP-Seq_ESCs_Human0.92969510
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92951556
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92202873
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.92191553
126SMAD_19615063_ChIP-ChIP_OVARY_Human0.91950708
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.91945313
128HTT_18923047_ChIP-ChIP_STHdh_Human0.91803313
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90833515
130TP63_22573176_ChIP-Seq_HFKS_Human0.90608306
131ER_23166858_ChIP-Seq_MCF-7_Human0.90110536
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89737037
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.89632112
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88339166
135RARB_24833708_ChIP-Seq_LIVER_Mouse0.88083677
136SMAD4_21799915_ChIP-Seq_A2780_Human0.87342612
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.87062164
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.85672943
139CEBPB_22108803_ChIP-Seq_LS180_Human0.85449943
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.84494022
141EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83879389
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83418088
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.83230933
144NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82747702
145EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82562986
146PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82529003
147GATA1_26923725_Chip-Seq_HPCs_Mouse0.81994792
148TAF2_19829295_ChIP-Seq_ESCs_Human0.81420407
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81204787
150* ZNF274_21170338_ChIP-Seq_K562_Hela0.80724374
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.80243759
152TCF4_22108803_ChIP-Seq_LS180_Human0.79563984
153RBPJ_21746931_ChIP-Seq_IB4_Human0.79213969
154P300_19829295_ChIP-Seq_ESCs_Human0.79096087
155CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78984352
156SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78835296
157* GATA6_25053715_ChIP-Seq_YYC3_Human0.78650454
158JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.78069633
159ETV1_20927104_ChIP-Seq_GIST48_Human0.76793984
160SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76557195
161MYC_19829295_ChIP-Seq_ESCs_Human0.74989464
162YY1_22570637_ChIP-Seq_MALME-3M_Human0.74867699
163BCAT_22108803_ChIP-Seq_LS180_Human0.74229396
164NANOG_18555785_Chip-Seq_ESCs_Mouse0.73229623
165TET1_21490601_ChIP-Seq_MESCs_Mouse0.72982634
166POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71972744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.85632423
2MP0002796_impaired_skin_barrier4.77698843
3MP0003183_abnormal_peptide_metabolism4.16180221
4MP0000579_abnormal_nail_morphology4.08195294
5MP0005501_abnormal_skin_physiology2.89100610
6MP0001188_hyperpigmentation2.88480881
7MP0005360_urolithiasis2.76506501
8MP0001666_abnormal_nutrient_absorption2.73727926
9MP0003879_abnormal_hair_cell2.73610207
10MP0004264_abnormal_extraembryonic_tissu2.72018258
11MP0003880_abnormal_central_pattern2.63453411
12MP0004381_abnormal_hair_follicle2.53411988
13MP0002822_catalepsy2.45765756
14MP0003866_abnormal_defecation2.44393419
15MP0003011_delayed_dark_adaptation2.29214203
16MP0002098_abnormal_vibrissa_morphology2.23577153
17MP0003941_abnormal_skin_development2.15217689
18MP0004859_abnormal_synaptic_plasticity2.12923429
19MP0001501_abnormal_sleep_pattern2.02366478
20MP0001216_abnormal_epidermal_layer1.97182127
21MP0004782_abnormal_surfactant_physiolog1.93434794
22MP0000462_abnormal_digestive_system1.93024434
23MP0003878_abnormal_ear_physiology1.91948804
24MP0005377_hearing/vestibular/ear_phenot1.91948804
25MP0000383_abnormal_hair_follicle1.91667826
26MP0000566_synostosis1.90035342
27MP0000467_abnormal_esophagus_morphology1.88983454
28MP0000427_abnormal_hair_cycle1.87196001
29MP0001664_abnormal_digestion1.82330912
30MP0010678_abnormal_skin_adnexa1.78932705
31MP0004270_analgesia1.77200348
32MP0000538_abnormal_urinary_bladder1.75857591
33MP0002876_abnormal_thyroid_physiology1.75664226
34MP0010771_integument_phenotype1.74785235
35MP0002254_reproductive_system_inflammat1.68531652
36MP0003635_abnormal_synaptic_transmissio1.58546560
37MP0001440_abnormal_grooming_behavior1.57971543
38MP0003453_abnormal_keratinocyte_physiol1.57589519
39MP0005275_abnormal_skin_tensile1.56507186
40MP0005083_abnormal_biliary_tract1.42382892
41MP0009745_abnormal_behavioral_response1.41676493
42MP0002063_abnormal_learning/memory/cond1.38649226
43MP0004947_skin_inflammation1.38178008
44MP0009780_abnormal_chondrocyte_physiolo1.36894877
45MP0008004_abnormal_stomach_pH1.36845761
46MP0000377_abnormal_hair_follicle1.34454361
47MP0004885_abnormal_endolymph1.33827273
48MP0010386_abnormal_urinary_bladder1.31368587
49MP0001873_stomach_inflammation1.28891632
50MP0002572_abnormal_emotion/affect_behav1.28169421
51MP0005409_darkened_coat_color1.24927431
52MP0000762_abnormal_tongue_morphology1.24418491
53MP0009379_abnormal_foot_pigmentation1.22291534
54MP0005499_abnormal_olfactory_system1.22059942
55MP0005394_taste/olfaction_phenotype1.22059942
56MP0000647_abnormal_sebaceous_gland1.20768477
57MP0002060_abnormal_skin_morphology1.20383144
58MP0002095_abnormal_skin_pigmentation1.18760880
59MP0008789_abnormal_olfactory_epithelium1.14924073
60MP0002064_seizures1.14872487
61MP0000537_abnormal_urethra_morphology1.14485889
62MP0005075_abnormal_melanosome_morpholog1.14209573
63MP0001663_abnormal_digestive_system1.11672581
64MP0005381_digestive/alimentary_phenotyp1.10134851
65MP0005367_renal/urinary_system_phenotyp1.09445095
66MP0000516_abnormal_urinary_system1.09445095
67MP0002234_abnormal_pharynx_morphology1.08181501
68MP0002736_abnormal_nociception_after1.08163771
69MP0005084_abnormal_gallbladder_morpholo1.07881861
70MP0003718_maternal_effect1.07637510
71MP0005448_abnormal_energy_balance1.05750254
72MP0003191_abnormal_cellular_cholesterol1.03901144
73MP0002734_abnormal_mechanical_nocicepti1.03259620
74MP0002277_abnormal_respiratory_mucosa1.02734021
75MP0001346_abnormal_lacrimal_gland0.98798447
76MP0001529_abnormal_vocalization0.98638169
77MP0002557_abnormal_social/conspecific_i0.97514227
78MP0000678_abnormal_parathyroid_gland0.96622776
79MP0001968_abnormal_touch/_nociception0.94758250
80MP0000367_abnormal_coat/_hair0.93379165
81MP0005310_abnormal_salivary_gland0.93247051
82MP0004742_abnormal_vestibular_system0.93149222
83MP0000477_abnormal_intestine_morphology0.92795668
84MP0004043_abnormal_pH_regulation0.90907915
85MP0003315_abnormal_perineum_morphology0.90309750
86MP0005646_abnormal_pituitary_gland0.89934858
87MP0003787_abnormal_imprinting0.89774374
88MP0001486_abnormal_startle_reflex0.89700120
89MP0003705_abnormal_hypodermis_morpholog0.89590661
90MP0001485_abnormal_pinna_reflex0.89461550
91MP0001191_abnormal_skin_condition0.89329776
92MP0001243_abnormal_dermal_layer0.88634906
93MP0002909_abnormal_adrenal_gland0.84865493
94MP0002272_abnormal_nervous_system0.82904659
95MP0010155_abnormal_intestine_physiology0.82357759
96MP0000470_abnormal_stomach_morphology0.80557305
97MP0005365_abnormal_bile_salt0.80329454
98MP0008569_lethality_at_weaning0.79428352
99MP0001984_abnormal_olfaction0.78043504
100MP0009931_abnormal_skin_appearance0.77078952
101MP0002733_abnormal_thermal_nociception0.77035117
102MP0003938_abnormal_ear_development0.76843787
103MP0008872_abnormal_physiological_respon0.75290755
104MP0004019_abnormal_vitamin_homeostasis0.72891148
105MP0001849_ear_inflammation0.72498294
106MP0001765_abnormal_ion_homeostasis0.72468827
107MP0006276_abnormal_autonomic_nervous0.70181304
108MP0001970_abnormal_pain_threshold0.69811506
109MP0005451_abnormal_body_composition0.69683686
110MP0008875_abnormal_xenobiotic_pharmacok0.69006772
111MP0005423_abnormal_somatic_nervous0.67653399
112MP0010352_gastrointestinal_tract_polyps0.67134003
113MP0003638_abnormal_response/metabolism_0.66589842
114MP0000490_abnormal_crypts_of0.64829733
115MP0002069_abnormal_eating/drinking_beha0.63255603
116MP0000627_abnormal_mammary_gland0.59478349
117MP0009053_abnormal_anal_canal0.59367328
118MP0001919_abnormal_reproductive_system0.54115240
119MP0000015_abnormal_ear_pigmentation0.53209433
120MP0005174_abnormal_tail_pigmentation0.52472839
121MP0002249_abnormal_larynx_morphology0.46542707
122MP0002282_abnormal_trachea_morphology0.46194355
123MP0001784_abnormal_fluid_regulation0.46000881
124MP0009643_abnormal_urine_homeostasis0.45726543
125MP0001756_abnormal_urination0.45659506
126MP0004185_abnormal_adipocyte_glucose0.45346298
127MP0001502_abnormal_circadian_rhythm0.45213502
128MP0000613_abnormal_salivary_gland0.43659904
129MP0000465_gastrointestinal_hemorrhage0.42554562
130MP0005636_abnormal_mineral_homeostasis0.40639226
131MP0002638_abnormal_pupillary_reflex0.36022302
132MP0002177_abnormal_outer_ear0.35288640
133MP0002111_abnormal_tail_morphology0.34886396
134MP0005551_abnormal_eye_electrophysiolog0.34757358
135MP0001905_abnormal_dopamine_level0.34755863
136MP0000371_diluted_coat_color0.34469049
137MP0002653_abnormal_ependyma_morphology0.34007644
138MP0001340_abnormal_eyelid_morphology0.33005088
139MP0002075_abnormal_coat/hair_pigmentati0.32275768
140MP0001186_pigmentation_phenotype0.30596870
141MP0002160_abnormal_reproductive_system0.30408586
142MP0001764_abnormal_homeostasis0.29272000
143MP0003566_abnormal_cell_adhesion0.29069772
144MP0003936_abnormal_reproductive_system0.27091845
145MP0005389_reproductive_system_phenotype0.26262871
146MP0003755_abnormal_palate_morphology0.26078533
147MP0006072_abnormal_retinal_apoptosis0.25464488
148MP0005085_abnormal_gallbladder_physiolo0.25402697

Predicted human phenotypes

RankGene SetZ-score
1Plantar hyperkeratosis (HP:0007556)5.82541916
2Abnormality of nail color (HP:0100643)5.48403093
3Palmoplantar hyperkeratosis (HP:0000972)5.43378147
4Woolly hair (HP:0002224)5.34229759
5Palmar hyperkeratosis (HP:0010765)5.27910414
6Increased IgE level (HP:0003212)5.27071186
7Fragile nails (HP:0001808)5.24762639
8Right ventricular cardiomyopathy (HP:0011663)5.15222594
9Focal motor seizures (HP:0011153)4.93655152
10Pili torti (HP:0003777)4.57392177
11Onycholysis (HP:0001806)4.49622473
12Ileus (HP:0002595)4.04860270
13Abnormality of secondary sexual hair (HP:0009888)3.95803518
14Abnormality of the axillary hair (HP:0100134)3.95803518
15Hypotrichosis (HP:0001006)3.90250181
16Natal tooth (HP:0000695)3.73932990
17Abnormal blistering of the skin (HP:0008066)3.70271744
18Nail dystrophy (HP:0008404)3.60070176
19Milia (HP:0001056)3.58609396
20Erythema (HP:0010783)3.52367988
21Furrowed tongue (HP:0000221)3.49457428
22Congenital ichthyosiform erythroderma (HP:0007431)3.47598836
23Pustule (HP:0200039)3.38804823
24Gangrene (HP:0100758)3.28037406
25Alopecia of scalp (HP:0002293)3.26517116
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.21402604
27Conjugated hyperbilirubinemia (HP:0002908)3.21207687
28Septate vagina (HP:0001153)3.05789513
29Curly hair (HP:0002212)3.05574542
30Absent eyelashes (HP:0000561)3.01445650
31Dry hair (HP:0011359)2.97054286
32Epileptic encephalopathy (HP:0200134)2.93894300
33Parakeratosis (HP:0001036)2.78021710
34Thick nail (HP:0001805)2.72293214
35Ridged nail (HP:0001807)2.69436324
36Absent hair (HP:0002298)2.66035054
37Myopathic facies (HP:0002058)2.64985336
38Concave nail (HP:0001598)2.64624767
39Lip pit (HP:0100267)2.64170783
40Erythroderma (HP:0001019)2.63978170
41Hyperactive renin-angiotensin system (HP:0000841)2.63791286
42Hamartoma of the eye (HP:0010568)2.62647884
43Advanced eruption of teeth (HP:0006288)2.54738880
44Sparse scalp hair (HP:0002209)2.53843587
45Sparse eyelashes (HP:0000653)2.47316800
46Dehydration (HP:0001944)2.45357384
47Malnutrition (HP:0004395)2.43789987
48Amniotic constriction ring (HP:0009775)2.38363293
49Abnormality of placental membranes (HP:0011409)2.38363293
50Amelogenesis imperfecta (HP:0000705)2.37967002
51Atonic seizures (HP:0010819)2.29108168
52Abnormal hair laboratory examination (HP:0003328)2.27579793
53Brittle hair (HP:0002299)2.26409889
54Syncope (HP:0001279)2.25409360
55Hyperventilation (HP:0002883)2.25088510
56Focal seizures (HP:0007359)2.20957513
57Febrile seizures (HP:0002373)2.20538454
58Abnormal hair whorl (HP:0010721)2.20504600
59Abnormality of the salivary glands (HP:0010286)2.17231570
60Poor suck (HP:0002033)2.16882124
61Abnormality of hair growth rate (HP:0011363)2.16617477
62Slow-growing hair (HP:0002217)2.16617477
63Visual hallucinations (HP:0002367)2.15359650
64Cheilitis (HP:0100825)2.15210864
65Villous atrophy (HP:0011473)2.14744792
66Abnormality of small intestinal villus morphology (HP:0011472)2.14744792
67Cupped ribs (HP:0000887)2.11984216
68Polyphagia (HP:0002591)2.07340316
69Ventricular fibrillation (HP:0001663)2.07065969
70Blepharitis (HP:0000498)2.06572866
71Follicular hyperkeratosis (HP:0007502)2.05626190
72Fatigable weakness (HP:0003473)2.05552149
73Abnormality of the neuromuscular junction (HP:0003398)2.05552149
74Hyperhidrosis (HP:0000975)2.05187837
75Ectropion (HP:0000656)2.04207529
76Abnormality of the gastric mucosa (HP:0004295)2.04159407
77Hypohidrosis (HP:0000966)2.03545050
78Asthma (HP:0002099)2.02084630
79Absence seizures (HP:0002121)2.01193678
80Lack of skin elasticity (HP:0100679)1.97706226
81Hoarse voice (HP:0001609)1.96899987
82Chronic diarrhea (HP:0002028)1.96620857
83Conjunctival hamartoma (HP:0100780)1.96372792
84Aplasia/hypoplasia of the uterus (HP:0008684)1.96268290
85Palmoplantar keratoderma (HP:0000982)1.96015910
86Oligomenorrhea (HP:0000876)1.95602390
87Corneal erosion (HP:0200020)1.94118451
88Popliteal pterygium (HP:0009756)1.93675400
89Corneal dystrophy (HP:0001131)1.92549174
90Anonychia (HP:0001798)1.92431167
91J-shaped sella turcica (HP:0002680)1.91103776
92Dialeptic seizures (HP:0011146)1.89648201
93Hypoplasia of the uterus (HP:0000013)1.88643612
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88158372
95Tongue fasciculations (HP:0001308)1.85581657
96Abnormality of chloride homeostasis (HP:0011422)1.83393450
97Acanthosis nigricans (HP:0000956)1.81599141
98Fine hair (HP:0002213)1.80417953
99Hyperthyroidism (HP:0000836)1.77915783
100Hypoplasia of dental enamel (HP:0006297)1.77779394
101Labial hypoplasia (HP:0000066)1.77541626
102Pruritus (HP:0000989)1.77175545
103B lymphocytopenia (HP:0010976)1.76578840
104Abnormality of B cell number (HP:0010975)1.76578840
105Absent eyebrow (HP:0002223)1.75851660
106Abnormality of glutamine family amino acid metabolism (HP:0010902)1.75771599
107Hypoplastic female external genitalia (HP:0012815)1.73660047
108Dry skin (HP:0000958)1.71041413
109Autoimmune hemolytic anemia (HP:0001890)1.68680742
110Autoamputation (HP:0001218)1.68593928
111Abnormality of the fingernails (HP:0001231)1.68467953
112Hypodontia (HP:0000668)1.68153663
113Abdominal distention (HP:0003270)1.67938710
114Congenital, generalized hypertrichosis (HP:0004540)1.67374138
115Decreased circulating renin level (HP:0003351)1.67034351
116Broad-based gait (HP:0002136)1.66465874
117Oral leukoplakia (HP:0002745)1.66349089
118Widely patent fontanelles and sutures (HP:0004492)1.65697424
119Esotropia (HP:0000565)1.65685863
120Abnormality of dental color (HP:0011073)1.65582423
121Abnormal eating behavior (HP:0100738)1.64411070
122Hypergammaglobulinemia (HP:0010702)1.64375711
123Abnormality of the vitamin B12 metabolism (HP:0004341)1.63011929
124Laryngomalacia (HP:0001601)1.60904893
125Axonal loss (HP:0003447)1.54531015
126Tubular atrophy (HP:0000092)1.51506410
127Carious teeth (HP:0000670)1.51274219
128Melanocytic nevus (HP:0000995)1.50980115
129Ulnar claw (HP:0001178)1.50265820
130Hypoplastic labia majora (HP:0000059)1.48948578
131Squamous cell carcinoma (HP:0002860)1.47893991
132Urticaria (HP:0001025)1.42446960
133Abnormality of permanent molar morphology (HP:0011071)1.41002435
134Abnormality of the dental root (HP:0006486)1.41002435
135Taurodontia (HP:0000679)1.41002435
136Paralysis (HP:0003470)1.40534062
137Oligodontia (HP:0000677)1.38697751
138Abnormality of the labia majora (HP:0012881)1.38587851
139Multifactorial inheritance (HP:0001426)1.36087181
140Hyperkalemia (HP:0002153)1.33618183
141Distal lower limb muscle weakness (HP:0009053)1.32698955
142Conical tooth (HP:0000698)1.30174922
143Recurrent corneal erosions (HP:0000495)1.29741482
144Renal dysplasia (HP:0000110)1.28991808
145Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.28007372
146Seborrheic dermatitis (HP:0001051)1.25414445
147Attenuation of retinal blood vessels (HP:0007843)1.25259037
148Testicular atrophy (HP:0000029)1.24259062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME14.79357347
2SIK34.37912983
3CASK4.31864170
4FRK3.74060197
5MAP3K123.72412594
6MST43.60275947
7MUSK3.45839964
8AKT33.42004141
9SIK13.06275712
10TRIB32.61173127
11NTRK32.56627062
12LMTK22.44761661
13MST1R2.14776334
14EPHA22.07188956
15MAP2K71.97797684
16IRAK31.92401980
17BCKDK1.91160241
18MAP3K91.86984832
19EPHA41.84495921
20CDK191.80079380
21BCR1.77844576
22VRK21.73413150
23PKN21.67188847
24CCNB11.67126988
25STK241.65398298
26IRAK11.60537154
27PIM21.60401038
28MAP3K21.59116639
29STK391.57768013
30PRKCI1.52818501
31MAP3K31.50644702
32PINK11.49481744
33FER1.41495079
34GRK61.38748426
35DAPK11.37828274
36TSSK61.35296301
37BRAF1.34086521
38MAP4K21.32455010
39EPHB21.32281917
40TAOK11.30500424
41WNK41.29952082
42ARAF1.29940574
43STK161.25395853
44NTRK21.25388558
45GRK11.22841008
46MAP3K41.21296372
47TNIK1.21224955
48TRIM281.14662673
49DAPK21.14530004
50PRKG21.14497344
51KSR11.11766370
52MAPK151.11498611
53MARK11.09493197
54IRAK21.05867707
55NEK61.01586912
56CDK31.00069676
57BMPR1B0.95453136
58MAP2K60.95132407
59MAP2K40.92558844
60MINK10.87831822
61PLK20.87618676
62IKBKB0.85452701
63TLK10.84901946
64MAP3K60.84415580
65BMPR20.84048940
66DYRK20.80155689
67CHUK0.79206921
68ERBB30.78892930
69RIPK40.78057147
70MAP2K20.77972003
71TESK10.75011315
72SMG10.74917112
73MAPKAPK30.74762602
74CAMK2B0.72182061
75MAPKAPK50.71398903
76TXK0.71223482
77EPHA30.69905705
78EPHB10.69321076
79CDK50.67571532
80PRKD20.67494721
81IRAK40.66666084
82PRKCE0.64671457
83SCYL20.62015433
84DYRK1A0.61753412
85ILK0.60872817
86TGFBR10.59372715
87TNK20.59169367
88MAPK130.58886404
89MYLK0.58687704
90LATS10.58487704
91ERN10.57994767
92TTK0.57511658
93MAP3K110.56125519
94RPS6KA20.55502194
95MET0.53917609
96IKBKE0.53894920
97PRKD30.52770503
98TAOK30.52554179
99SGK20.51458359
100PRKCG0.51127462
101NME20.47313234
102PHKG20.46210993
103PHKG10.46210993
104WNK30.46177158
105RPS6KB10.45443150
106STK380.43251103
107NUAK10.42090391
108GRK50.41883046
109SIK20.41738614
110PTK20.41053426
111CDK80.40936207
112CAMK2A0.40826932
113EEF2K0.40615697
114MAP2K10.40108306
115CDK70.38576954
116RPS6KA40.38388146
117TBK10.38085218
118CSNK1A10.38029380
119MAP3K10.37343002
120PRKCA0.36608724
121LRRK20.36038276
122HIPK20.33847226
123TRPM70.33382507
124CDK180.32631103
125ADRBK20.32246881
126OXSR10.32172807
127PBK0.30832785
128VRK10.30654193
129PAK40.30128172
130PRPF4B0.29725891
131PIK3CA0.29330519
132PTK60.28469852
133EIF2AK30.28199978
134PRKD10.28191608
135TESK20.26855108
136SGK2230.25238397
137SGK4940.25238397
138CAMK2G0.24942899
139SYK0.23447711
140SGK30.23433303
141PLK30.23167583
142RPS6KB20.22921102
143PAK30.22589365
144MAPKAPK20.22147295
145ADRBK10.19743649
146PRKACA0.19705276
147DAPK30.18735064
148RPS6KA10.17312859
149FGFR10.17059105
150MARK30.16875368
151MAPK90.16040974
152DYRK1B0.16023829
153CAMK2D0.15501947
154SRPK10.15028509

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.03471088
2Renin-angiotensin system_Homo sapiens_hsa046143.48660639
3Collecting duct acid secretion_Homo sapiens_hsa049662.99836387
4Mineral absorption_Homo sapiens_hsa049782.96763922
5Synaptic vesicle cycle_Homo sapiens_hsa047212.67274091
6Vitamin digestion and absorption_Homo sapiens_hsa049772.52602355
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.51704928
8Vibrio cholerae infection_Homo sapiens_hsa051102.35698962
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34098715
10Nicotine addiction_Homo sapiens_hsa050332.27647990
11Fatty acid elongation_Homo sapiens_hsa000622.24903639
12Galactose metabolism_Homo sapiens_hsa000522.14816722
13Ovarian steroidogenesis_Homo sapiens_hsa049132.13610509
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08865614
15Sphingolipid metabolism_Homo sapiens_hsa006001.88056347
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.82990798
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82565641
18Fructose and mannose metabolism_Homo sapiens_hsa000511.80075967
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.75580902
20Oxidative phosphorylation_Homo sapiens_hsa001901.75545572
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.65512258
22Linoleic acid metabolism_Homo sapiens_hsa005911.63925673
23Sulfur metabolism_Homo sapiens_hsa009201.62487291
24Chemical carcinogenesis_Homo sapiens_hsa052041.57563959
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.57022433
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56929668
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.54386883
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53008405
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50739492
30Amphetamine addiction_Homo sapiens_hsa050311.49990574
31Steroid biosynthesis_Homo sapiens_hsa001001.49816946
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46763430
33Retinol metabolism_Homo sapiens_hsa008301.43719352
34Insulin secretion_Homo sapiens_hsa049111.37261395
35Taste transduction_Homo sapiens_hsa047421.29828724
36ABC transporters_Homo sapiens_hsa020101.28335070
37Sulfur relay system_Homo sapiens_hsa041221.28236997
38beta-Alanine metabolism_Homo sapiens_hsa004101.26326939
39Proteasome_Homo sapiens_hsa030501.25692819
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.25230972
41Circadian entrainment_Homo sapiens_hsa047131.23421121
42Serotonergic synapse_Homo sapiens_hsa047261.20963178
43Protein digestion and absorption_Homo sapiens_hsa049741.20407658
44Arachidonic acid metabolism_Homo sapiens_hsa005901.19157791
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18625663
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17283858
47Olfactory transduction_Homo sapiens_hsa047401.16833937
48Folate biosynthesis_Homo sapiens_hsa007901.15417307
49RNA polymerase_Homo sapiens_hsa030201.12197945
50Nitrogen metabolism_Homo sapiens_hsa009101.08512210
51Alzheimers disease_Homo sapiens_hsa050101.08124000
52Dopaminergic synapse_Homo sapiens_hsa047281.06680271
53Long-term potentiation_Homo sapiens_hsa047201.05364916
54Gastric acid secretion_Homo sapiens_hsa049711.04028764
55Salivary secretion_Homo sapiens_hsa049701.01099342
56Ether lipid metabolism_Homo sapiens_hsa005650.95832243
57Glutamatergic synapse_Homo sapiens_hsa047240.95500139
58* Steroid hormone biosynthesis_Homo sapiens_hsa001400.93454823
59Histidine metabolism_Homo sapiens_hsa003400.92676903
60Renin secretion_Homo sapiens_hsa049240.92107425
61Circadian rhythm_Homo sapiens_hsa047100.91688313
62Long-term depression_Homo sapiens_hsa047300.90625003
63Morphine addiction_Homo sapiens_hsa050320.89659969
64Parkinsons disease_Homo sapiens_hsa050120.89247586
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86876217
66Cocaine addiction_Homo sapiens_hsa050300.84200619
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83497799
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82538608
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81900796
70GABAergic synapse_Homo sapiens_hsa047270.81313645
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80673044
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79962191
73Fatty acid biosynthesis_Homo sapiens_hsa000610.79084071
74Pancreatic secretion_Homo sapiens_hsa049720.78944004
75GnRH signaling pathway_Homo sapiens_hsa049120.77002376
76Tryptophan metabolism_Homo sapiens_hsa003800.76684251
77Tyrosine metabolism_Homo sapiens_hsa003500.71696875
78Rheumatoid arthritis_Homo sapiens_hsa053230.70151491
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68151908
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67204667
81Calcium signaling pathway_Homo sapiens_hsa040200.66873345
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66729183
83Regulation of autophagy_Homo sapiens_hsa041400.66353285
84Huntingtons disease_Homo sapiens_hsa050160.64827780
85Metabolic pathways_Homo sapiens_hsa011000.64668336
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64598007
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64084927
88Phenylalanine metabolism_Homo sapiens_hsa003600.60124508
89Axon guidance_Homo sapiens_hsa043600.59216880
90Starch and sucrose metabolism_Homo sapiens_hsa005000.57758047
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57182883
92Purine metabolism_Homo sapiens_hsa002300.55973485
93Choline metabolism in cancer_Homo sapiens_hsa052310.55509947
94Cholinergic synapse_Homo sapiens_hsa047250.55369530
95Selenocompound metabolism_Homo sapiens_hsa004500.54995880
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.54395159
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53489795
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53073920
99Butanoate metabolism_Homo sapiens_hsa006500.50262095
100Type II diabetes mellitus_Homo sapiens_hsa049300.50090546
101Fatty acid metabolism_Homo sapiens_hsa012120.49709059
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47849232
103Tight junction_Homo sapiens_hsa045300.47036225
104Inositol phosphate metabolism_Homo sapiens_hsa005620.46566308
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46375461
106Glycerolipid metabolism_Homo sapiens_hsa005610.45547217
107Arginine and proline metabolism_Homo sapiens_hsa003300.45132785
108Oxytocin signaling pathway_Homo sapiens_hsa049210.44979844
109Bile secretion_Homo sapiens_hsa049760.44304540
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43061896
111Caffeine metabolism_Homo sapiens_hsa002320.41560166
112AMPK signaling pathway_Homo sapiens_hsa041520.39517396
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39488460
114PPAR signaling pathway_Homo sapiens_hsa033200.39459992
115Peroxisome_Homo sapiens_hsa041460.39404872
116Ras signaling pathway_Homo sapiens_hsa040140.38720042
117Phototransduction_Homo sapiens_hsa047440.35671614
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34330534
119Glutathione metabolism_Homo sapiens_hsa004800.33979734
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33874018
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.33748748
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.32608295
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32166592
124Thyroid hormone synthesis_Homo sapiens_hsa049180.32155323
125Insulin resistance_Homo sapiens_hsa049310.32134444
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31471261
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31398939
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31389554
129Hepatitis C_Homo sapiens_hsa051600.30676282
130Salmonella infection_Homo sapiens_hsa051320.29909372
131Glucagon signaling pathway_Homo sapiens_hsa049220.29679796
132Phagosome_Homo sapiens_hsa041450.29034639
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.28835298
134Lysosome_Homo sapiens_hsa041420.28636504
135VEGF signaling pathway_Homo sapiens_hsa043700.27923563
136Gap junction_Homo sapiens_hsa045400.27389896
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27042376
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26850619
139cAMP signaling pathway_Homo sapiens_hsa040240.26829340
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23446600
141Hippo signaling pathway_Homo sapiens_hsa043900.22659567
142Insulin signaling pathway_Homo sapiens_hsa049100.22596960

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