SULT4A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.32126088
2synaptic vesicle maturation (GO:0016188)6.12436479
3synaptic vesicle exocytosis (GO:0016079)5.89946564
4glutamate secretion (GO:0014047)5.66092201
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.53206798
6locomotory exploration behavior (GO:0035641)5.41463046
7regulation of synaptic vesicle exocytosis (GO:2000300)5.40341324
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.23260044
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.22017599
10vocalization behavior (GO:0071625)5.17861317
11neuronal action potential propagation (GO:0019227)5.08690448
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.02189350
13regulation of synaptic vesicle transport (GO:1902803)4.78059888
14protein localization to synapse (GO:0035418)4.74426276
15regulation of glutamate receptor signaling pathway (GO:1900449)4.70688890
16neurotransmitter secretion (GO:0007269)4.67583690
17cerebellar granule cell differentiation (GO:0021707)4.44113586
18L-amino acid import (GO:0043092)4.42804931
19regulation of neuronal synaptic plasticity (GO:0048168)4.42563627
20neuron cell-cell adhesion (GO:0007158)4.42222881
21exploration behavior (GO:0035640)4.33225321
22proline transport (GO:0015824)4.24606363
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.21622415
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.21077672
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11149221
26positive regulation of dendritic spine development (GO:0060999)4.00638185
27layer formation in cerebral cortex (GO:0021819)3.97880621
28neuromuscular process controlling posture (GO:0050884)3.97369362
29amino acid import (GO:0043090)3.95729397
30positive regulation of dendritic spine morphogenesis (GO:0061003)3.95627233
31synaptic transmission, glutamatergic (GO:0035249)3.95190642
32regulation of synapse structural plasticity (GO:0051823)3.92602796
33gamma-aminobutyric acid transport (GO:0015812)3.90710488
34neuron-neuron synaptic transmission (GO:0007270)3.84815979
35synaptic vesicle endocytosis (GO:0048488)3.83351174
36potassium ion homeostasis (GO:0055075)3.82430519
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81551216
38neurotransmitter transport (GO:0006836)3.78416215
39cellular potassium ion homeostasis (GO:0030007)3.78032023
40glutamate receptor signaling pathway (GO:0007215)3.76501057
41neurotransmitter-gated ion channel clustering (GO:0072578)3.71526133
42activation of protein kinase A activity (GO:0034199)3.70861643
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67137178
44cell migration in hindbrain (GO:0021535)3.66585034
45regulation of synapse maturation (GO:0090128)3.64742484
46negative regulation of dendrite morphogenesis (GO:0050774)3.63836931
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.62858595
48central nervous system myelination (GO:0022010)3.62259026
49axon ensheathment in central nervous system (GO:0032291)3.62259026
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.62247217
51regulation of neurotransmitter secretion (GO:0046928)3.59780301
52neuromuscular process controlling balance (GO:0050885)3.57074887
53long-term memory (GO:0007616)3.56621704
54potassium ion import (GO:0010107)3.56441642
55regulation of synaptic plasticity (GO:0048167)3.56293659
56cerebellar Purkinje cell differentiation (GO:0021702)3.55315693
57positive regulation of membrane potential (GO:0045838)3.51357796
58regulation of postsynaptic membrane potential (GO:0060078)3.51087146
59regulation of neurotransmitter levels (GO:0001505)3.49412631
60sodium ion export (GO:0071436)3.47649641
61positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47204154
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44698982
63regulation of dendritic spine development (GO:0060998)3.44018362
64membrane depolarization during action potential (GO:0086010)3.43601959
65neuromuscular synaptic transmission (GO:0007274)3.43499414
66dendritic spine morphogenesis (GO:0060997)3.42061478
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38636484
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38422886
69positive regulation of synapse maturation (GO:0090129)3.35929049
70cellular sodium ion homeostasis (GO:0006883)3.32788471
71regulation of neurotransmitter transport (GO:0051588)3.31691064
72dendritic spine organization (GO:0097061)3.31322777
73presynaptic membrane organization (GO:0097090)3.30459117
74glycine transport (GO:0015816)3.30293272
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29795655
76regulation of vesicle fusion (GO:0031338)3.28702391
77neuron recognition (GO:0008038)3.27745576
78transmission of nerve impulse (GO:0019226)3.27512734
79long-term synaptic potentiation (GO:0060291)3.26341502
80positive regulation of neurotransmitter transport (GO:0051590)3.26043721
81regulation of ARF protein signal transduction (GO:0032012)3.24970427
82regulation of dendritic spine morphogenesis (GO:0061001)3.23648256
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23467456
84regulation of synaptic transmission, glutamatergic (GO:0051966)3.23420116
85gamma-aminobutyric acid signaling pathway (GO:0007214)3.21297715
86acidic amino acid transport (GO:0015800)3.20709806
87presynaptic membrane assembly (GO:0097105)3.20583122
88vesicle transport along microtubule (GO:0047496)3.20511328
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19774553
90membrane depolarization (GO:0051899)3.19384539
91neuromuscular process (GO:0050905)3.17324133
92positive regulation of neurotransmitter secretion (GO:0001956)3.13673917
93negative regulation of microtubule polymerization (GO:0031115)3.12888668
94negative regulation of dendrite development (GO:2000171)3.11381075
95synaptic transmission (GO:0007268)3.10086602
96cell differentiation in hindbrain (GO:0021533)3.08470087
97cell communication by electrical coupling (GO:0010644)3.08392780
98innervation (GO:0060384)3.07148674
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05780135
100neurotransmitter uptake (GO:0001504)3.05544896
101regulation of synaptic transmission (GO:0050804)3.03688589
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03423759
103detection of calcium ion (GO:0005513)3.02749593
104regulation of exocytosis (GO:0017157)3.02622298
105cerebellar Purkinje cell layer development (GO:0021680)3.02262022
106membrane hyperpolarization (GO:0060081)3.01122949
107postsynaptic membrane organization (GO:0001941)3.00704001
108positive regulation of synaptic transmission (GO:0050806)3.00096403
109mating behavior (GO:0007617)2.99571854
110neuronal ion channel clustering (GO:0045161)2.98901671
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.98772608
112organelle transport along microtubule (GO:0072384)2.97712768
113response to auditory stimulus (GO:0010996)2.97521757
114learning (GO:0007612)2.96586674
115regulation of voltage-gated calcium channel activity (GO:1901385)2.96367832
116axonal fasciculation (GO:0007413)2.95833412
117prepulse inhibition (GO:0060134)2.94486766
118synaptic vesicle transport (GO:0048489)2.94210990
119establishment of synaptic vesicle localization (GO:0097480)2.94210990
120calcium ion-dependent exocytosis (GO:0017156)2.93875377
121regulation of cAMP-dependent protein kinase activity (GO:2000479)2.89268339
122dendrite morphogenesis (GO:0048813)2.88456422
123auditory behavior (GO:0031223)2.88313035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86820560
2GBX2_23144817_ChIP-Seq_PC3_Human3.33673380
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21035474
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06602863
5* REST_21632747_ChIP-Seq_MESCs_Mouse3.05618666
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05609480
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.82217928
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76962492
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76734131
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76734131
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57887434
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57313055
13* REST_18959480_ChIP-ChIP_MESCs_Mouse2.57271408
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57060927
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47845764
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46685157
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.46050712
18DROSHA_22980978_ChIP-Seq_HELA_Human2.43924780
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33801391
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30743726
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.21317136
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21232924
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.19693156
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.16559763
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15519481
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14675618
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08524004
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.03254595
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97491257
30AR_21572438_ChIP-Seq_LNCaP_Human1.76603768
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75989465
32TAF15_26573619_Chip-Seq_HEK293_Human1.73818224
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70548966
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67890621
35* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67047584
36* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.61997720
37SMAD4_21799915_ChIP-Seq_A2780_Human1.56699117
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55389688
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43364571
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39133491
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35598922
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.34849224
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32069867
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32042928
45ZNF274_21170338_ChIP-Seq_K562_Hela1.27595687
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.26257802
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22867124
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.22506853
49KDM2B_26808549_Chip-Seq_K562_Human1.22033152
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21982674
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20841745
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20609758
53P300_19829295_ChIP-Seq_ESCs_Human1.18862118
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17980251
55AR_19668381_ChIP-Seq_PC3_Human1.16755004
56AR_25329375_ChIP-Seq_VCAP_Human1.14921265
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.14250371
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12442501
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11897495
60STAT3_23295773_ChIP-Seq_U87_Human1.11146977
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10820629
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10022937
63RNF2_27304074_Chip-Seq_NSC_Mouse1.08785446
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.08235718
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07521017
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04549143
67* TET1_21490601_ChIP-Seq_MESCs_Mouse1.03749332
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03509131
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03194272
70CTCF_27219007_Chip-Seq_Bcells_Human1.02032340
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.01346284
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00614383
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99825955
74CBX2_27304074_Chip-Seq_ESCs_Mouse0.99174769
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99069798
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98883477
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98347078
78TCF4_23295773_ChIP-Seq_U87_Human0.97344871
79YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97019731
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95615653
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95545486
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.95486506
83AHR_22903824_ChIP-Seq_MCF-7_Human0.95031618
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93511811
85* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93233375
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93020843
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91974674
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91475127
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.91008035
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90263737
91OCT4_19829295_ChIP-Seq_ESCs_Human0.88125840
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86875266
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.86414437
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.85750321
95VDR_22108803_ChIP-Seq_LS180_Human0.85743801
96* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85661930
97DPY_21335234_ChIP-Seq_ESCs_Mouse0.85591022
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.84314339
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84157400
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82291051
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82291051
102RUNX2_22187159_ChIP-Seq_PCA_Human0.82232004
103TP53_20018659_ChIP-ChIP_R1E_Mouse0.81883270
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80796957
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80402487
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.79826899
107JUN_21703547_ChIP-Seq_K562_Human0.79643191
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79494404
109* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79429591
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79291472
111IGF1R_20145208_ChIP-Seq_DFB_Human0.79260919
112SOX9_26525672_Chip-Seq_HEART_Mouse0.78298614
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77532810
114RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74051540
115KLF4_19829295_ChIP-Seq_ESCs_Human0.74028779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.28208070
2MP0003880_abnormal_central_pattern4.80856756
3MP0003635_abnormal_synaptic_transmissio4.06078576
4MP0004270_analgesia3.97316137
5MP0001968_abnormal_touch/_nociception3.73019750
6MP0009745_abnormal_behavioral_response3.32844032
7MP0002063_abnormal_learning/memory/cond3.25404501
8MP0009046_muscle_twitch3.23995761
9MP0002064_seizures3.19568052
10MP0002735_abnormal_chemical_nociception3.09583643
11MP0002736_abnormal_nociception_after3.06805596
12MP0002734_abnormal_mechanical_nocicepti2.97488161
13MP0002572_abnormal_emotion/affect_behav2.77487025
14MP0002822_catalepsy2.74160163
15MP0002272_abnormal_nervous_system2.72297103
16MP0005423_abnormal_somatic_nervous2.58614189
17MP0002733_abnormal_thermal_nociception2.57863935
18MP0001970_abnormal_pain_threshold2.42907871
19MP0001486_abnormal_startle_reflex2.36818362
20MP0004858_abnormal_nervous_system2.24418153
21MP0006276_abnormal_autonomic_nervous2.22110854
22MP0001501_abnormal_sleep_pattern2.17316126
23MP0001440_abnormal_grooming_behavior2.11138062
24MP0002067_abnormal_sensory_capabilities2.10039633
25MP0002184_abnormal_innervation1.92691459
26MP0004811_abnormal_neuron_physiology1.88568388
27MP0008569_lethality_at_weaning1.85209984
28MP0003329_amyloid_beta_deposits1.83507977
29MP0004924_abnormal_behavior1.72546225
30MP0005386_behavior/neurological_phenoty1.72546225
31MP0000955_abnormal_spinal_cord1.69530556
32MP0000778_abnormal_nervous_system1.67621417
33MP0003123_paternal_imprinting1.66490952
34MP0002557_abnormal_social/conspecific_i1.64775318
35MP0009780_abnormal_chondrocyte_physiolo1.62881550
36MP0002909_abnormal_adrenal_gland1.58729093
37MP0001984_abnormal_olfaction1.57158226
38MP0005646_abnormal_pituitary_gland1.49647228
39MP0003879_abnormal_hair_cell1.48164085
40MP0004142_abnormal_muscle_tone1.45802017
41MP0002066_abnormal_motor_capabilities/c1.44941287
42MP0002882_abnormal_neuron_morphology1.44319945
43MP0003633_abnormal_nervous_system1.39747679
44MP0005645_abnormal_hypothalamus_physiol1.36773728
45MP0003787_abnormal_imprinting1.34172727
46MP0001529_abnormal_vocalization1.28772321
47MP0003122_maternal_imprinting1.25875346
48MP0001905_abnormal_dopamine_level1.25714025
49MP0008877_abnormal_DNA_methylation1.25518701
50MP0003631_nervous_system_phenotype1.16959445
51MP0001502_abnormal_circadian_rhythm1.16768686
52MP0000751_myopathy1.16563214
53MP0004885_abnormal_endolymph1.14989346
54MP0008872_abnormal_physiological_respon1.09134051
55MP0003121_genomic_imprinting1.06533280
56MP0002152_abnormal_brain_morphology1.03977969
57MP0002229_neurodegeneration1.02149201
58MP0008874_decreased_physiological_sensi0.98315808
59MP0003283_abnormal_digestive_organ0.94823574
60MP0010386_abnormal_urinary_bladder0.93479249
61MP0004145_abnormal_muscle_electrophysio0.91376999
62MP0002069_abnormal_eating/drinking_beha0.87440275
63MP0004147_increased_porphyrin_level0.86100191
64MP0003634_abnormal_glial_cell0.85792359
65MP0001188_hyperpigmentation0.85150677
66MP0004233_abnormal_muscle_weight0.82909509
67MP0005394_taste/olfaction_phenotype0.82880451
68MP0005499_abnormal_olfactory_system0.82880451
69MP0005535_abnormal_body_temperature0.80703278
70MP0002752_abnormal_somatic_nervous0.80164807
71MP0001963_abnormal_hearing_physiology0.78220570
72MP0000604_amyloidosis0.78025576
73MP0000013_abnormal_adipose_tissue0.77324091
74MP0001986_abnormal_taste_sensitivity0.75202215
75MP0003632_abnormal_nervous_system0.74583439
76MP0004742_abnormal_vestibular_system0.72534771
77MP0003075_altered_response_to0.72246438
78MP0004085_abnormal_heartbeat0.71530441
79MP0002837_dystrophic_cardiac_calcinosis0.70082652
80MP0005171_absent_coat_pigmentation0.69525526
81MP0005551_abnormal_eye_electrophysiolog0.69177634
82MP0008961_abnormal_basal_metabolism0.69091377
83MP0002751_abnormal_autonomic_nervous0.67068070
84MP0001346_abnormal_lacrimal_gland0.66850700
85MP0002653_abnormal_ependyma_morphology0.65615882
86MP0001177_atelectasis0.63768910
87MP0000920_abnormal_myelination0.63318418
88MP0005623_abnormal_meninges_morphology0.62323920
89MP0003137_abnormal_impulse_conducting0.62311605
90MP0001485_abnormal_pinna_reflex0.60203783
91MP0003172_abnormal_lysosome_physiology0.59098217
92MP0001943_abnormal_respiration0.58953755
93MP0000026_abnormal_inner_ear0.58714045
94MP0001664_abnormal_digestion0.58566616
95MP0003690_abnormal_glial_cell0.58321932
96MP0003938_abnormal_ear_development0.58315842
97MP0005167_abnormal_blood-brain_barrier0.56993488
98MP0000569_abnormal_digit_pigmentation0.56937425
99MP0001348_abnormal_lacrimal_gland0.56062011
100MP0000631_abnormal_neuroendocrine_gland0.55983172
101MP0001299_abnormal_eye_distance/0.55442312
102MP0002090_abnormal_vision0.55280588
103MP0004484_altered_response_of0.54557912
104MP0010768_mortality/aging0.54263988
105MP0010769_abnormal_survival0.53365453
106MP0003956_abnormal_body_size0.52533821
107MP0002876_abnormal_thyroid_physiology0.51993388
108MP0002638_abnormal_pupillary_reflex0.51689227
109MP0010770_preweaning_lethality0.51061099
110MP0002082_postnatal_lethality0.51061099
111MP0004215_abnormal_myocardial_fiber0.51007804
112MP0003861_abnormal_nervous_system0.51000442
113MP0000566_synostosis0.49747300
114MP0000579_abnormal_nail_morphology0.47054389
115MP0004130_abnormal_muscle_cell0.45423144
116MP0000639_abnormal_adrenal_gland0.43211159

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.79332173
2Focal motor seizures (HP:0011153)7.42307560
3Focal seizures (HP:0007359)5.71251271
4Visual hallucinations (HP:0002367)5.32283895
5Atonic seizures (HP:0010819)5.31863627
6Febrile seizures (HP:0002373)4.95272363
7Epileptic encephalopathy (HP:0200134)4.74467618
8Absence seizures (HP:0002121)4.36189520
9Action tremor (HP:0002345)4.33947209
10Progressive cerebellar ataxia (HP:0002073)4.33870850
11Dialeptic seizures (HP:0011146)3.94836550
12Generalized tonic-clonic seizures (HP:0002069)3.84899605
13Supranuclear gaze palsy (HP:0000605)3.69602888
14Ankle clonus (HP:0011448)3.57222878
15Cerebral hypomyelination (HP:0006808)3.41830098
16Abnormality of the lower motor neuron (HP:0002366)3.26791169
17Impaired vibration sensation in the lower limbs (HP:0002166)3.24074527
18Pheochromocytoma (HP:0002666)3.17322822
19Gaze-evoked nystagmus (HP:0000640)3.11868251
20Depression (HP:0000716)3.11465638
21Urinary bladder sphincter dysfunction (HP:0002839)3.06323864
22Dysdiadochokinesis (HP:0002075)3.04420861
23Amblyopia (HP:0000646)3.03472307
24Abnormal eating behavior (HP:0100738)3.02265549
25Poor eye contact (HP:0000817)3.01908146
26Truncal ataxia (HP:0002078)2.97873144
27Broad-based gait (HP:0002136)2.96620069
28Termporal pattern (HP:0011008)2.92326193
29Insidious onset (HP:0003587)2.92326193
30Annular pancreas (HP:0001734)2.90998705
31Anxiety (HP:0000739)2.90989960
32Dysmetria (HP:0001310)2.90870951
33Tetraplegia (HP:0002445)2.88714421
34Neuroendocrine neoplasm (HP:0100634)2.80570802
35Urinary urgency (HP:0000012)2.79811294
36Postural instability (HP:0002172)2.78747941
37Abnormal social behavior (HP:0012433)2.77469058
38Impaired social interactions (HP:0000735)2.77469058
39Neuronal loss in central nervous system (HP:0002529)2.74579015
40Sleep apnea (HP:0010535)2.69168802
41Mutism (HP:0002300)2.68974456
42Obstructive sleep apnea (HP:0002870)2.67045544
43Progressive inability to walk (HP:0002505)2.59456406
44Hyperventilation (HP:0002883)2.58354847
45Limb dystonia (HP:0002451)2.55863704
46Spastic gait (HP:0002064)2.55303132
47Papilledema (HP:0001085)2.55169465
48Torticollis (HP:0000473)2.54031775
49Ventricular fibrillation (HP:0001663)2.53891844
50Ulnar claw (HP:0001178)2.53338441
51Fetal akinesia sequence (HP:0001989)2.50386582
52Bradykinesia (HP:0002067)2.46696648
53Impaired smooth pursuit (HP:0007772)2.46313247
54Failure to thrive in infancy (HP:0001531)2.45070017
55Scanning speech (HP:0002168)2.44288703
56Apathy (HP:0000741)2.40884923
57Focal dystonia (HP:0004373)2.39576760
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38357776
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.38357776
60Genetic anticipation (HP:0003743)2.32152288
61Spastic tetraparesis (HP:0001285)2.29493192
62Epileptiform EEG discharges (HP:0011182)2.28459552
63Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.25648410
64Impaired vibratory sensation (HP:0002495)2.23558441
65Abnormality of the corticospinal tract (HP:0002492)2.21615697
66Status epilepticus (HP:0002133)2.21113591
67EEG with generalized epileptiform discharges (HP:0011198)2.20524851
68Neoplasm of the peripheral nervous system (HP:0100007)2.18637906
69Hemiparesis (HP:0001269)2.18552878
70Diminished motivation (HP:0000745)2.18125069
71Dysmetric saccades (HP:0000641)2.17904436
72Craniofacial dystonia (HP:0012179)2.17195396
73Morphological abnormality of the pyramidal tract (HP:0002062)2.17151894
74Lower limb muscle weakness (HP:0007340)2.17087331
75CNS hypomyelination (HP:0003429)2.16626821
76Intention tremor (HP:0002080)2.15690270
77Abnormality of pain sensation (HP:0010832)2.13522210
78Impaired pain sensation (HP:0007328)2.13522210
79Delusions (HP:0000746)2.13377867
80Polyphagia (HP:0002591)2.13056601
81Diplopia (HP:0000651)2.13004607
82Abnormality of binocular vision (HP:0011514)2.13004607
83Abnormality of ocular smooth pursuit (HP:0000617)2.12823570
84Drooling (HP:0002307)2.12663413
85Excessive salivation (HP:0003781)2.12663413
86Hypsarrhythmia (HP:0002521)2.11368777
87Hypercortisolism (HP:0001578)2.11105241
88Choreoathetosis (HP:0001266)2.09820988
89Rigidity (HP:0002063)2.08774938
90Stereotypic behavior (HP:0000733)2.07058375
91Hemiplegia (HP:0002301)2.06949799
92Inability to walk (HP:0002540)2.03888110
93Cerebral inclusion bodies (HP:0100314)2.02649038
94Amyotrophic lateral sclerosis (HP:0007354)2.02567288
95Hypoventilation (HP:0002791)1.99225613
96Specific learning disability (HP:0001328)1.97200027
97Split foot (HP:0001839)1.95932088
98Incomplete penetrance (HP:0003829)1.95576683
99Insomnia (HP:0100785)1.95531897
100Spastic tetraplegia (HP:0002510)1.95112400
101Clonus (HP:0002169)1.93662714
102Megalencephaly (HP:0001355)1.92892707
103Peripheral hypomyelination (HP:0007182)1.92788790
104Rapidly progressive (HP:0003678)1.91939809
105Generalized myoclonic seizures (HP:0002123)1.91638020
106Resting tremor (HP:0002322)1.91025410
107Postural tremor (HP:0002174)1.90296368
108Pointed chin (HP:0000307)1.89046696
109Neurofibrillary tangles (HP:0002185)1.89021723
110Absent speech (HP:0001344)1.88098751
111Gait ataxia (HP:0002066)1.86186475
112Hammertoe (HP:0001765)1.84629876
113Myotonia (HP:0002486)1.82853935
114Agitation (HP:0000713)1.81649848
115Psychosis (HP:0000709)1.80612535
116Akinesia (HP:0002304)1.80233372
117Lower limb asymmetry (HP:0100559)1.80035003
118Gait imbalance (HP:0002141)1.79494645
119Spinal canal stenosis (HP:0003416)1.78582516
120Unsteady gait (HP:0002317)1.76921622
121Lower limb amyotrophy (HP:0007210)1.71452254
122Abnormality of saccadic eye movements (HP:0000570)1.69488037
123Memory impairment (HP:0002354)1.68479713
124Hypoplasia of the corpus callosum (HP:0002079)1.66768804
125Paraplegia (HP:0010550)1.65589663
126Aplasia of the phalanges of the hand (HP:0009802)1.65111356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.30464711
2MAP3K94.11600526
3EPHA43.55378174
4MAP3K43.04500496
5MINK12.96387186
6DAPK22.59078099
7MAP3K122.55397699
8MAP2K72.51280829
9MARK12.44652244
10KSR22.40329260
11PAK62.22900924
12NTRK12.20986365
13MAP2K42.01096896
14DAPK12.00543067
15CASK1.86794654
16GRK51.78785979
17ARAF1.77852135
18RIPK41.74512166
19NTRK21.72896608
20CAMKK11.72349628
21PRKD31.72035044
22CDK191.59657979
23LATS21.51064759
24CDK51.48911155
25UHMK11.45844589
26PLK21.44256870
27PINK11.35813355
28STK381.34844654
29KSR11.33573852
30MAP3K21.33467439
31TYRO31.27581361
32LMTK21.24970239
33PRPF4B1.24726304
34PHKG21.21022176
35PHKG11.21022176
36MAPK131.16340230
37PRKCG1.15895743
38PNCK1.15607899
39SIK21.06823656
40CAMKK21.01466244
41CDK180.94247786
42RET0.93568623
43TAOK10.93533215
44CDK140.93110144
45CAMK2A0.93103584
46FES0.91777431
47CDK150.91557840
48MAP3K130.90485518
49SGK2230.85301739
50SGK4940.85301739
51RAF10.83079491
52RIPK10.82815743
53TNIK0.81628324
54MAP3K60.80733172
55CDK11A0.80060025
56NEK10.78440170
57STK110.75715604
58TNK20.75700819
59PTK2B0.74864190
60CAMK2B0.73245539
61OXSR10.73083915
62NEK60.72541737
63CAMK40.70213355
64CAMK10.70190702
65PRKCH0.68114899
66PKN10.67591549
67FGR0.67263983
68DDR20.66909921
69MAP3K10.65787052
70ICK0.65714940
71AKT30.65204494
72SGK20.64433506
73ALK0.63709146
74LIMK10.62087054
75MATK0.59701250
76MAPK120.59555123
77CSNK1G20.58401115
78PAK30.58286194
79SGK30.57283289
80CDC42BPA0.56823078
81PDK10.56122010
82CAMK2G0.55365732
83SGK10.55330027
84MAP2K10.55150593
85BMPR20.53672473
86CAMK1G0.52734629
87PDPK10.52141292
88CCNB10.51525059
89MAP3K110.49191106
90BRSK10.49119191
91FER0.49112515
92WNK10.48976989
93PRKCZ0.48707833
94DAPK30.47447567
95CAMK2D0.47374105
96BRAF0.46863917
97MARK20.46680825
98DYRK1A0.45518596
99NME10.45424975
100SCYL20.45057723
101MAPK100.44025381
102RPS6KA30.43351388
103FGFR20.42523457
104PRKCE0.41291916
105DYRK20.39156244
106SIK30.38352894
107FYN0.37866092
108RPS6KA20.37002976
109TESK10.36628518
110ROCK20.35916649
111PRKCA0.35625620
112CSNK1E0.34160823
113ADRBK10.33090390
114CSNK1G30.31660873
115PRKACA0.30324094
116PRKG10.30291233
117CAMK1D0.29424984
118CSNK1A1L0.28884936
119MAPK80.28576088
120CSNK1D0.26780197
121PRKCB0.26156501
122ERBB20.24168001

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.88884910
2Nicotine addiction_Homo sapiens_hsa050333.52686306
3Olfactory transduction_Homo sapiens_hsa047402.98570412
4GABAergic synapse_Homo sapiens_hsa047272.60495678
5Long-term potentiation_Homo sapiens_hsa047202.57808247
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55197658
7Circadian entrainment_Homo sapiens_hsa047132.53194845
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.48801605
9Glutamatergic synapse_Homo sapiens_hsa047242.39922359
10Amphetamine addiction_Homo sapiens_hsa050312.37349175
11Morphine addiction_Homo sapiens_hsa050322.35931575
12Dopaminergic synapse_Homo sapiens_hsa047282.18540477
13Salivary secretion_Homo sapiens_hsa049702.09463339
14Insulin secretion_Homo sapiens_hsa049112.01503651
15Collecting duct acid secretion_Homo sapiens_hsa049661.91627209
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86114657
17Cholinergic synapse_Homo sapiens_hsa047251.85697411
18Gastric acid secretion_Homo sapiens_hsa049711.84799546
19Taste transduction_Homo sapiens_hsa047421.83763289
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68686896
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66964011
22Long-term depression_Homo sapiens_hsa047301.65673833
23Serotonergic synapse_Homo sapiens_hsa047261.60298524
24Oxytocin signaling pathway_Homo sapiens_hsa049211.56504845
25Renin secretion_Homo sapiens_hsa049241.55929441
26GnRH signaling pathway_Homo sapiens_hsa049121.50093144
27Calcium signaling pathway_Homo sapiens_hsa040201.47646944
28Cocaine addiction_Homo sapiens_hsa050301.44407922
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44385651
30Gap junction_Homo sapiens_hsa045401.42751304
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42039179
32Vitamin B6 metabolism_Homo sapiens_hsa007501.39959424
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36650838
34Vibrio cholerae infection_Homo sapiens_hsa051101.18026020
35Estrogen signaling pathway_Homo sapiens_hsa049151.15593467
36Cardiac muscle contraction_Homo sapiens_hsa042601.14274914
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13918135
38cAMP signaling pathway_Homo sapiens_hsa040241.13438297
39Glioma_Homo sapiens_hsa052141.13168541
40Oocyte meiosis_Homo sapiens_hsa041141.07001105
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06856706
42ErbB signaling pathway_Homo sapiens_hsa040121.05998696
43Type II diabetes mellitus_Homo sapiens_hsa049301.04558236
44Melanogenesis_Homo sapiens_hsa049161.00466938
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99151478
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98599318
47Dorso-ventral axis formation_Homo sapiens_hsa043200.97975923
48Axon guidance_Homo sapiens_hsa043600.92541119
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88248172
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87906103
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82923837
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.82735074
53Phototransduction_Homo sapiens_hsa047440.78804606
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.73978075
55Pancreatic secretion_Homo sapiens_hsa049720.73193412
56Thyroid hormone synthesis_Homo sapiens_hsa049180.71798224
57VEGF signaling pathway_Homo sapiens_hsa043700.71021940
58Nitrogen metabolism_Homo sapiens_hsa009100.70657298
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.69854074
60MAPK signaling pathway_Homo sapiens_hsa040100.69728698
61Choline metabolism in cancer_Homo sapiens_hsa052310.68400234
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63998037
63mTOR signaling pathway_Homo sapiens_hsa041500.62903782
64Oxidative phosphorylation_Homo sapiens_hsa001900.62865850
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62704642
66Alzheimers disease_Homo sapiens_hsa050100.61332015
67Glucagon signaling pathway_Homo sapiens_hsa049220.58984285
68Endocytosis_Homo sapiens_hsa041440.56785515
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56610720
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55618077
71Insulin signaling pathway_Homo sapiens_hsa049100.53693153
72Ras signaling pathway_Homo sapiens_hsa040140.53543127
73Parkinsons disease_Homo sapiens_hsa050120.53447465
74Dilated cardiomyopathy_Homo sapiens_hsa054140.52541539
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.52388334
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51624198
77Rap1 signaling pathway_Homo sapiens_hsa040150.51109636
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50321820
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50036578
80Circadian rhythm_Homo sapiens_hsa047100.48901082
81Alcoholism_Homo sapiens_hsa050340.46533319
82Bile secretion_Homo sapiens_hsa049760.45655913
83Endometrial cancer_Homo sapiens_hsa052130.45286911
84Fatty acid biosynthesis_Homo sapiens_hsa000610.45091413
85Inositol phosphate metabolism_Homo sapiens_hsa005620.45048318
86Prion diseases_Homo sapiens_hsa050200.44982722
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43082454
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42681648
89Type I diabetes mellitus_Homo sapiens_hsa049400.42390148
90Arginine and proline metabolism_Homo sapiens_hsa003300.42005238
91Wnt signaling pathway_Homo sapiens_hsa043100.39007250
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38646481
93Non-small cell lung cancer_Homo sapiens_hsa052230.35488244
94Arginine biosynthesis_Homo sapiens_hsa002200.34351608
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33737697
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.33202789
97Regulation of autophagy_Homo sapiens_hsa041400.32668187
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31372716
99Huntingtons disease_Homo sapiens_hsa050160.30751863
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30262075
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29668351
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29605159
103Mineral absorption_Homo sapiens_hsa049780.28959856
104Renal cell carcinoma_Homo sapiens_hsa052110.28256796
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27256973
106Hippo signaling pathway_Homo sapiens_hsa043900.25459173
107Tight junction_Homo sapiens_hsa045300.24610637
108AMPK signaling pathway_Homo sapiens_hsa041520.22174391
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21804238
110Ovarian steroidogenesis_Homo sapiens_hsa049130.18953617
111beta-Alanine metabolism_Homo sapiens_hsa004100.16357238
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16019086
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15027836

Most similar genes based on co-expression Upload to Enrichr

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