SUMF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.08147874
2proline metabolic process (GO:0006560)7.08026361
3embryonic process involved in female pregnancy (GO:0060136)6.40786316
4regulation of integrin activation (GO:0033623)5.93249590
5positive regulation of protein homooligomerization (GO:0032464)5.69092704
6cellular response to ATP (GO:0071318)5.28126214
7transcription from mitochondrial promoter (GO:0006390)5.14634073
8regulation of protein homooligomerization (GO:0032462)4.79289083
9oxidative demethylation (GO:0070989)4.74485160
10establishment of apical/basal cell polarity (GO:0035089)4.56940289
11replication fork processing (GO:0031297)4.51778003
12glutamine family amino acid biosynthetic process (GO:0009084)4.38873665
13sulfur amino acid catabolic process (GO:0000098)4.35375611
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.28234112
15protein retention in ER lumen (GO:0006621)4.22342444
16embryonic placenta development (GO:0001892)4.15998704
17negative regulation of fatty acid biosynthetic process (GO:0045717)3.99303730
18positive regulation of protein oligomerization (GO:0032461)3.88860132
19establishment of monopolar cell polarity (GO:0061162)3.77270949
20establishment or maintenance of monopolar cell polarity (GO:0061339)3.77270949
21keratan sulfate catabolic process (GO:0042340)3.75240155
22sphingoid metabolic process (GO:0046519)3.67044722
23arginine catabolic process (GO:0006527)3.60573075
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.57973342
25regulation of podosome assembly (GO:0071801)3.57249787
26apoptotic cell clearance (GO:0043277)3.57169546
27cellular response to zinc ion (GO:0071294)3.55362013
28protein localization to endosome (GO:0036010)3.53480420
29glial cell migration (GO:0008347)3.45745341
30regulation of mononuclear cell migration (GO:0071675)3.42796257
31regulation of macrophage chemotaxis (GO:0010758)3.42292708
32indole-containing compound catabolic process (GO:0042436)3.40595465
33indolalkylamine catabolic process (GO:0046218)3.40595465
34tryptophan catabolic process (GO:0006569)3.40595465
35negative regulation of JAK-STAT cascade (GO:0046426)3.38294292
36xenobiotic catabolic process (GO:0042178)3.37322980
37regulation of translational fidelity (GO:0006450)3.35656347
38mitochondrial DNA metabolic process (GO:0032042)3.35259956
39negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.34460554
40alkaloid metabolic process (GO:0009820)3.29047037
41very-low-density lipoprotein particle assembly (GO:0034379)3.27194956
42protein heterotrimerization (GO:0070208)3.25226104
43response to lipoprotein particle (GO:0055094)3.25053109
44anatomical structure regression (GO:0060033)3.18779386
45UDP-N-acetylglucosamine metabolic process (GO:0006047)3.18542980
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17514077
47negative regulation of cell cycle arrest (GO:0071157)3.16967910
48DNA deamination (GO:0045006)3.13940664
49intestinal cholesterol absorption (GO:0030299)3.13243804
50regulation of protein oligomerization (GO:0032459)3.13018902
51regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.12333663
52negative regulation of chondrocyte differentiation (GO:0032331)3.11279018
53negative regulation of calcium ion transport into cytosol (GO:0010523)3.09308846
54sphingosine metabolic process (GO:0006670)3.08864141
55convergent extension (GO:0060026)3.08281682
56protein targeting to vacuole (GO:0006623)3.07466949
57protein targeting to lysosome (GO:0006622)3.07466949
58establishment of protein localization to vacuole (GO:0072666)3.07466949
59negative regulation of complement activation (GO:0045916)3.07218419
60mitotic G1 DNA damage checkpoint (GO:0031571)3.06444569
61regulation of early endosome to late endosome transport (GO:2000641)3.05780109
62negative regulation of cartilage development (GO:0061037)3.03904696
63COPII vesicle coating (GO:0048208)3.00430664
64regulation of cholesterol homeostasis (GO:2000188)2.99868993
65exogenous drug catabolic process (GO:0042738)2.98412441
66poly(A)+ mRNA export from nucleus (GO:0016973)2.96861713
67nitric oxide biosynthetic process (GO:0006809)2.95978561
68positive regulation of receptor recycling (GO:0001921)2.95549261
69DNA strand renaturation (GO:0000733)2.95239021
70apoptotic process involved in morphogenesis (GO:0060561)2.95103390
71regulation of response to reactive oxygen species (GO:1901031)2.92104980
72drug catabolic process (GO:0042737)2.89237075
73cellular zinc ion homeostasis (GO:0006882)2.89090037
74hypotonic response (GO:0006971)2.86385800
75negative regulation of tumor necrosis factor production (GO:0032720)2.85751775
76oligosaccharide catabolic process (GO:0009313)2.85224672
77regulation of hippo signaling (GO:0035330)2.85100614
78embryonic camera-type eye development (GO:0031076)2.83256260
79diol metabolic process (GO:0034311)2.82550034
80activation of Rac GTPase activity (GO:0032863)2.79204766
81indolalkylamine metabolic process (GO:0006586)2.77771569
82negative regulation of protein activation cascade (GO:2000258)2.77648596
83low-density lipoprotein particle clearance (GO:0034383)2.77618173
84arginine metabolic process (GO:0006525)2.77460400
854-hydroxyproline metabolic process (GO:0019471)2.77430487
86mitotic G1/S transition checkpoint (GO:0044819)2.76797761
87negative regulation of Ras GTPase activity (GO:0034261)2.76754914
88positive regulation of developmental pigmentation (GO:0048087)2.76655468
89signal peptide processing (GO:0006465)2.75631185
90regulation of integrin-mediated signaling pathway (GO:2001044)2.75513700
91negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.75442233
92COPI coating of Golgi vesicle (GO:0048205)2.74513397
93Golgi transport vesicle coating (GO:0048200)2.74513397
94regulation of hydrogen peroxide-induced cell death (GO:1903205)2.74480129
95mRNA cleavage (GO:0006379)2.73591455
96tryptophan metabolic process (GO:0006568)2.73210864
97cellular response to lithium ion (GO:0071285)2.71505338
98L-ascorbic acid metabolic process (GO:0019852)2.69987005
99negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.68127803
100glandular epithelial cell development (GO:0002068)2.67253615
101negative regulation of nitric oxide biosynthetic process (GO:0045019)2.65315254
102regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.63932379
103positive regulation of cell adhesion mediated by integrin (GO:0033630)2.63023477
104cellular response to toxic substance (GO:0097237)2.62710451
105negative regulation of protein oligomerization (GO:0032460)2.62305843
106negative regulation of response to reactive oxygen species (GO:1901032)2.60773023
107iron ion import (GO:0097286)2.60273273
108N-glycan processing (GO:0006491)2.59824778
109embryonic eye morphogenesis (GO:0048048)2.59525572
110negative regulation of humoral immune response (GO:0002921)2.58762378
111negative regulation of mast cell activation (GO:0033004)2.57984396
112peptidyl-proline hydroxylation (GO:0019511)2.57556112
113regulation of phospholipase A2 activity (GO:0032429)2.55876795
114membrane invagination (GO:0010324)2.54907912
115G1 DNA damage checkpoint (GO:0044783)2.54467548
116lysosome organization (GO:0007040)2.53510127
117lytic vacuole organization (GO:0080171)2.53510127
118ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.52059986
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.51604783
120positive regulation by host of viral transcription (GO:0043923)2.50420757
121kynurenine metabolic process (GO:0070189)2.50000798
122negative regulation of interleukin-12 production (GO:0032695)2.49582359
123regulation of cholesterol storage (GO:0010885)2.48499066
124labyrinthine layer development (GO:0060711)2.48322396
125positive regulation of T cell apoptotic process (GO:0070234)2.47815533
126face development (GO:0060324)2.47348482
127aromatic amino acid family catabolic process (GO:0009074)2.46808755
128positive regulation of lymphocyte apoptotic process (GO:0070230)2.45968020
129negative regulation of stress fiber assembly (GO:0051497)2.45921752
130basement membrane organization (GO:0071711)2.45796905
131negative regulation of fatty acid metabolic process (GO:0045922)2.44094333
132macroautophagy (GO:0016236)2.44017560
133positive regulation of lamellipodium assembly (GO:0010592)2.43988479
134peptide catabolic process (GO:0043171)2.43345184
135regulation of protein polyubiquitination (GO:1902914)2.43004610
136triglyceride homeostasis (GO:0070328)2.42696990
137phospholipid translocation (GO:0045332)2.41755646
138lipid translocation (GO:0034204)2.41755646
139pyrimidine-containing compound salvage (GO:0008655)2.38760321
140pyrimidine nucleoside salvage (GO:0043097)2.38760321
141intracellular pH reduction (GO:0051452)2.37254171
142response to nitrosative stress (GO:0051409)2.37159313
143fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.36810887
144platelet-derived growth factor receptor signaling pathway (GO:0048008)2.35865379
145diaphragm development (GO:0060539)2.35650140
146type B pancreatic cell proliferation (GO:0044342)2.30552797
147establishment of protein localization to Golgi (GO:0072600)2.29713361
148cellular ketone body metabolic process (GO:0046950)2.29353960
149bile acid biosynthetic process (GO:0006699)2.27167383
150negative regulation of protein kinase B signaling (GO:0051898)2.26332854
151endosome to melanosome transport (GO:0035646)2.25545599
152endosome to pigment granule transport (GO:0043485)2.25545599
153pH reduction (GO:0045851)2.24071820
154cell adhesion mediated by integrin (GO:0033627)2.23827098
155positive regulation of cell size (GO:0045793)2.23505004
156benzene-containing compound metabolic process (GO:0042537)2.23268664
157amino sugar catabolic process (GO:0046348)2.23243460
158prostate gland growth (GO:0060736)2.22725998
159negative regulation of leukocyte chemotaxis (GO:0002689)2.21410025
160glycosphingolipid catabolic process (GO:0046479)2.19601079
161interleukin-6-mediated signaling pathway (GO:0070102)2.19377355
162positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.18316249
163glomerular basement membrane development (GO:0032836)2.17752040
164negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.17028785
165negative regulation of vascular permeability (GO:0043116)2.16419735
166cilium or flagellum-dependent cell motility (GO:0001539)2.16335983
167aromatic amino acid family metabolic process (GO:0009072)2.15552494
168negative regulation of lipid storage (GO:0010888)2.15238065
169negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.11912490
170glycolipid catabolic process (GO:0019377)2.08306713
171neurotransmitter biosynthetic process (GO:0042136)2.06814393
172regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.04926047
173positive regulation of focal adhesion assembly (GO:0051894)2.04214844
174positive regulation of cell junction assembly (GO:1901890)2.04214844
175dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.03813428
176positive regulation of prostaglandin secretion (GO:0032308)2.02502935
177cellular response to arsenic-containing substance (GO:0071243)2.00932285
178adhesion of symbiont to host cell (GO:0044650)2.00407851
179virion attachment to host cell (GO:0019062)2.00407851
180ceramide catabolic process (GO:0046514)1.99833445
181ketone body metabolic process (GO:1902224)1.99700680
182retina vasculature morphogenesis in camera-type eye (GO:0061299)1.98645052
183blood vessel maturation (GO:0001955)1.97355754
184epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)1.96192256
185nucleoside salvage (GO:0043174)1.95625832
186pyridine nucleotide biosynthetic process (GO:0019363)1.95333403
187nicotinamide nucleotide biosynthetic process (GO:0019359)1.95333403
188positive regulation of icosanoid secretion (GO:0032305)1.94910986
189positive regulation of cholesterol transport (GO:0032376)1.94903838
190positive regulation of sterol transport (GO:0032373)1.94903838
191protein hydroxylation (GO:0018126)1.94262730
192positive regulation of vasculogenesis (GO:2001214)1.93623997
193lung lobe morphogenesis (GO:0060463)1.92482942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse3.13941383
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.06282165
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.80765510
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77136671
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.68996745
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.63921971
7* LXR_22158963_ChIP-Seq_LIVER_Mouse2.44200377
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.31100705
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.31100705
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.31100705
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.30063895
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.24905011
13LXR_22292898_ChIP-Seq_THP-1_Human2.22214505
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.20078775
15AHR_22903824_ChIP-Seq_MCF-7_Human2.19961842
16VDR_21846776_ChIP-Seq_THP-1_Human2.18658475
17* CJUN_26792858_Chip-Seq_BT549_Human2.14219743
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14118708
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.13755797
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13552329
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.08935392
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07142186
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99256983
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99107842
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97406124
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.96493263
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.96447437
28GBX2_23144817_ChIP-Seq_PC3_Human1.92360115
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92192840
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91324359
31RACK7_27058665_Chip-Seq_MCF-7_Human1.84412015
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82455059
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.80878999
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.80397898
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80319092
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80314423
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77035482
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76947871
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.74956901
40JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74325642
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73558464
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.72516079
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72430893
44ZNF274_21170338_ChIP-Seq_K562_Hela1.67177516
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66554989
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.65640999
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65256801
48CLOCK_20551151_ChIP-Seq_293T_Human1.65131567
49TP53_16413492_ChIP-PET_HCT116_Human1.64174756
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62235132
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62081593
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61773378
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61007201
54* PIAS1_25552417_ChIP-Seq_VCAP_Human1.56880272
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55872450
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55856709
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55646061
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55646061
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55589097
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.54288772
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52794071
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52275881
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51227546
64VDR_24787735_ChIP-Seq_THP-1_Human1.50039796
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49834057
66* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49727849
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49454747
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.49347026
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.48599912
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47994461
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.47776673
72BRD4_25478319_ChIP-Seq_HGPS_Human1.47678458
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.46523078
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.46425469
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.45636630
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44583472
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43037543
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42663905
79TP63_23658742_ChIP-Seq_EP156T_Human1.42357036
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42155459
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41448255
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41146053
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41015004
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40812255
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40103105
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39369861
87* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38253842
88* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37454767
89BCAT_22108803_ChIP-Seq_LS180_Human1.36674915
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.36219233
91IGF1R_20145208_ChIP-Seq_DFB_Human1.34739309
92KDM2B_26808549_Chip-Seq_DND41_Human1.33738138
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32465463
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31867631
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31104660
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30153220
97STAT3_23295773_ChIP-Seq_U87_Human1.29855943
98TP53_18474530_ChIP-ChIP_U2OS_Human1.29648965
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29595477
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29595477
101ZNF263_19887448_ChIP-Seq_K562_Human1.29581011
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29248930
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28942437
104ER_23166858_ChIP-Seq_MCF-7_Human1.28797169
105CDX2_22108803_ChIP-Seq_LS180_Human1.27917164
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27847561
107IRF8_21731497_ChIP-ChIP_J774_Mouse1.26888802
108GATA4_25053715_ChIP-Seq_YYC3_Human1.25989184
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25890495
110* SMAD4_21799915_ChIP-Seq_A2780_Human1.25530229
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25427478
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24949939
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24423102
114CDX2_20551321_ChIP-Seq_CACO-2_Human1.23289281
115RXRA_24833708_ChIP-Seq_LIVER_Mouse1.23016117
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22953553
117GATA1_22025678_ChIP-Seq_K562_Human1.22869385
118SOX2_20726797_ChIP-Seq_SW620_Human1.22578268
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19110241
120* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19058901
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18538859
122FOXO3_23340844_ChIP-Seq_DLD1_Human1.18289665
123TAF15_26573619_Chip-Seq_HEK293_Human1.18143378
124CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17889006
125SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17676749
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16454739
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.16259281
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16163842
129TCF4_22108803_ChIP-Seq_LS180_Human1.16083649
130VDR_24763502_ChIP-Seq_THP-1_Human1.16030293
131ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15152091
132CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14142221
133MYC_22102868_ChIP-Seq_BL_Human1.14009211
134SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13750099
135ATF3_27146783_Chip-Seq_COLON_Human1.12231256
136NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11920771
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11283697
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10640840
139* AR_25329375_ChIP-Seq_VCAP_Human1.09979444
140STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09899345
141IRF8_27001747_Chip-Seq_BMDM_Mouse1.09596938
142* TFEB_21752829_ChIP-Seq_HELA_Human1.09130670
143* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08353660
144EP300_21415370_ChIP-Seq_HL-1_Mouse1.08102993
145SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07540033
146* P300_19829295_ChIP-Seq_ESCs_Human1.07490968
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07441059
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07198487
149PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07033627
150TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06742077
151PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06430375
152RARB_24833708_ChIP-Seq_LIVER_Mouse1.06416773
153FOXA2_19822575_ChIP-Seq_HepG2_Human1.06055724
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06040662
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05639191
156ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04864919
157SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04726328
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04203009
159TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04022256
160CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04001528
161CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03631998
162PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03613533
163IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02923128
164KDM2B_26808549_Chip-Seq_K562_Human1.02671475
165SMAD4_21741376_ChIP-Seq_EPCs_Human1.02217509
166EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01732345
167MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01673208
168CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01636959
169NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00750151
170MAF_26560356_Chip-Seq_TH1_Human1.00423032
171SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00347325
172FLI1_27457419_Chip-Seq_LIVER_Mouse1.00288750
173NANOG_21062744_ChIP-ChIP_HESCs_Human1.00252706
174TCF4_23295773_ChIP-Seq_U87_Human0.99705587
175RARA_24833708_ChIP-Seq_LIVER_Mouse0.99368329
176SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98833201
177ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98632691
178P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98298210
179GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98251184
180* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96957439
181PRDM14_20953172_ChIP-Seq_ESCs_Human0.96565497
182SCL_19346495_ChIP-Seq_HPC-7_Human0.96131531
183SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94768531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.79699606
2MP0009278_abnormal_bone_marrow3.70864776
3MP0008438_abnormal_cutaneous_collagen3.58858222
4MP0006054_spinal_hemorrhage3.55283130
5MP0005171_absent_coat_pigmentation3.03579916
6MP0003705_abnormal_hypodermis_morpholog2.91663376
7MP0003646_muscle_fatigue2.74670403
8MP0003283_abnormal_digestive_organ2.72834807
9MP0003172_abnormal_lysosome_physiology2.69852651
10MP0005167_abnormal_blood-brain_barrier2.64199243
11MP0010368_abnormal_lymphatic_system2.56854317
12MP0002009_preneoplasia2.47452252
13MP0003950_abnormal_plasma_membrane2.39317131
14MP0000383_abnormal_hair_follicle2.35339243
15MP0005365_abnormal_bile_salt2.33281862
16MP0004043_abnormal_pH_regulation2.33126451
17MP0003724_increased_susceptibility_to2.22814341
18MP0005076_abnormal_cell_differentiation2.15482748
19MP0005085_abnormal_gallbladder_physiolo2.13583254
20MP0010030_abnormal_orbit_morphology2.12300259
21MP0004233_abnormal_muscle_weight2.06465219
22MP0008057_abnormal_DNA_replication2.05532941
23MP0010352_gastrointestinal_tract_polyps2.01320464
24MP0010678_abnormal_skin_adnexa2.01006691
25MP0004272_abnormal_basement_membrane1.94842414
26MP0002139_abnormal_hepatobiliary_system1.86694227
27MP0003453_abnormal_keratinocyte_physiol1.84425094
28MP0010386_abnormal_urinary_bladder1.82150192
29MP0002877_abnormal_melanocyte_morpholog1.81662691
30MP0002234_abnormal_pharynx_morphology1.78342247
31MP0005397_hematopoietic_system_phenotyp1.74606190
32MP0001545_abnormal_hematopoietic_system1.74606190
33MP0005360_urolithiasis1.72473029
34MP0000569_abnormal_digit_pigmentation1.72314606
35MP0009764_decreased_sensitivity_to1.70614263
36MP0009053_abnormal_anal_canal1.62300025
37MP0003566_abnormal_cell_adhesion1.60235053
38MP0003045_fibrosis1.49170219
39MP0002060_abnormal_skin_morphology1.49136828
40MP0005275_abnormal_skin_tensile1.46285902
41MP0003191_abnormal_cellular_cholesterol1.45374687
42MP0008875_abnormal_xenobiotic_pharmacok1.45170236
43MP0004858_abnormal_nervous_system1.44074902
44MP0009840_abnormal_foam_cell1.39629570
45MP0003279_aneurysm1.39189068
46MP0000538_abnormal_urinary_bladder1.38981014
47MP0000427_abnormal_hair_cycle1.36656295
48MP0005023_abnormal_wound_healing1.36617091
49MP0005508_abnormal_skeleton_morphology1.30965379
50MP0004883_abnormal_blood_vessel1.30858177
51MP0003252_abnormal_bile_duct1.30600974
52MP0001542_abnormal_bone_strength1.30109389
53MP0000371_diluted_coat_color1.29600588
54MP0002166_altered_tumor_susceptibility1.28784524
55MP0005164_abnormal_response_to1.28611854
56MP0001756_abnormal_urination1.23912040
57MP0001501_abnormal_sleep_pattern1.23522117
58MP0000604_amyloidosis1.22739162
59MP0000685_abnormal_immune_system1.22092142
60MP0002148_abnormal_hypersensitivity_rea1.21632169
61MP0003195_calcinosis1.20882783
62MP0003075_altered_response_to1.20643086
63MP0003183_abnormal_peptide_metabolism1.17601865
64MP0002282_abnormal_trachea_morphology1.17549470
65MP0003300_gastrointestinal_ulcer1.14470907
66MP0000467_abnormal_esophagus_morphology1.13471156
67MP0001958_emphysema1.12295828
68MP0009115_abnormal_fat_cell1.11898340
69MP0005503_abnormal_tendon_morphology1.11093024
70MP0009384_cardiac_valve_regurgitation1.09979300
71MP0002295_abnormal_pulmonary_circulatio1.09486926
72MP0002168_other_aberrant_phenotype1.09270044
73MP0000639_abnormal_adrenal_gland1.08740444
74MP0004019_abnormal_vitamin_homeostasis1.07574631
75MP0003828_pulmonary_edema1.06475385
76MP0000767_abnormal_smooth_muscle1.06379652
77MP0004185_abnormal_adipocyte_glucose1.06373933
78MP0010307_abnormal_tumor_latency1.06235761
79MP0005220_abnormal_exocrine_pancreas1.05316179
80MP0005595_abnormal_vascular_smooth1.02194803
81MP0003890_abnormal_embryonic-extraembry1.01947785
82MP0002006_tumorigenesis1.00002033
83MP0003303_peritoneal_inflammation0.99939307
84MP0005174_abnormal_tail_pigmentation0.99708653
85MP0005310_abnormal_salivary_gland0.99084359
86MP0003436_decreased_susceptibility_to0.98223189
87MP0002419_abnormal_innate_immunity0.96998357
88MP0001664_abnormal_digestion0.96190954
89MP0001764_abnormal_homeostasis0.95720138
90* MP0000609_abnormal_liver_physiology0.93638892
91MP0003091_abnormal_cell_migration0.92855008
92MP0005390_skeleton_phenotype0.92635972
93MP0003656_abnormal_erythrocyte_physiolo0.91166323
94MP0009643_abnormal_urine_homeostasis0.90241629
95MP0001661_extended_life_span0.89272605
96MP0002998_abnormal_bone_remodeling0.89143329
97MP0002896_abnormal_bone_mineralization0.88853347
98MP0000230_abnormal_systemic_arterial0.88314936
99MP0003806_abnormal_nucleotide_metabolis0.87202915
100MP0005332_abnormal_amino_acid0.87127443
101MP0002405_respiratory_system_inflammati0.85618099
102MP0009780_abnormal_chondrocyte_physiolo0.85118467
103MP0002138_abnormal_hepatobiliary_system0.84978958
104MP0002933_joint_inflammation0.84670852
105MP0002086_abnormal_extraembryonic_tissu0.84016461
106MP0005464_abnormal_platelet_physiology0.84007200
107MP0005083_abnormal_biliary_tract0.82667163
108MP0001243_abnormal_dermal_layer0.81449469
109MP0000470_abnormal_stomach_morphology0.80737502
110MP0000490_abnormal_crypts_of0.80005264
111MP0000343_altered_response_to0.79723234
112MP0005395_other_phenotype0.79616036
113MP0004130_abnormal_muscle_cell0.79481985
114MP0002971_abnormal_brown_adipose0.79010112
115MP0000598_abnormal_liver_morphology0.78974918
116MP0005319_abnormal_enzyme/_coenzyme0.78773568
117MP0005257_abnormal_intraocular_pressure0.78498132
118MP0005377_hearing/vestibular/ear_phenot0.78476568
119MP0003878_abnormal_ear_physiology0.78476568
120MP0000013_abnormal_adipose_tissue0.78372322
121MP0002249_abnormal_larynx_morphology0.78107215
122MP0005165_increased_susceptibility_to0.77966982
123MP0005623_abnormal_meninges_morphology0.77849279
124MP0010329_abnormal_lipoprotein_level0.77555615
125MP0002269_muscular_atrophy0.76562721
126MP0003448_altered_tumor_morphology0.75842230
127MP0000249_abnormal_blood_vessel0.75679375
128MP0000579_abnormal_nail_morphology0.75575004
129MP0002118_abnormal_lipid_homeostasis0.75341570
130MP0005248_abnormal_Harderian_gland0.75100644
131MP0002090_abnormal_vision0.74823830
132MP0000462_abnormal_digestive_system0.74358634
133MP0009785_altered_susceptibility_to0.73630957
134MP0003119_abnormal_digestive_system0.73209479
135MP0008775_abnormal_heart_ventricle0.72780306
136MP0000003_abnormal_adipose_tissue0.72629000
137MP0002876_abnormal_thyroid_physiology0.72508317
138MP0000858_altered_metastatic_potential0.71989589
139MP0004133_heterotaxia0.71881662
140MP0002135_abnormal_kidney_morphology0.71732678
141MP0001533_abnormal_skeleton_physiology0.71676589
142MP0008469_abnormal_protein_level0.71100334
143MP0000465_gastrointestinal_hemorrhage0.70485954
144* MP0006082_CNS_inflammation0.70337430
145MP0005670_abnormal_white_adipose0.70049554
146MP0001845_abnormal_inflammatory_respons0.69729719
147MP0004264_abnormal_extraembryonic_tissu0.69584979
148MP0001666_abnormal_nutrient_absorption0.69138027
149MP0005666_abnormal_adipose_tissue0.69071032
150MP0005375_adipose_tissue_phenotype0.67676717
151MP0002254_reproductive_system_inflammat0.67169324
152MP0002111_abnormal_tail_morphology0.65924894
153MP0000516_abnormal_urinary_system0.63761850
154MP0005367_renal/urinary_system_phenotyp0.63761850
155MP0001340_abnormal_eyelid_morphology0.63642405

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.74123440
2Abnormality of liposaccharide metabolism (HP:0010968)5.74123440
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.74123440
4Turricephaly (HP:0000262)4.54756328
5Alopecia of scalp (HP:0002293)4.22521248
6Cerebral aneurysm (HP:0004944)4.21808584
7Pustule (HP:0200039)4.21727332
8Autoimmune thrombocytopenia (HP:0001973)4.17067184
9Ulnar bowing (HP:0003031)4.10971812
10Increased IgM level (HP:0003496)3.98195921
11* Urinary glycosaminoglycan excretion (HP:0003541)3.88205638
12* Mucopolysacchariduria (HP:0008155)3.88205638
13* Dysostosis multiplex (HP:0000943)3.83195942
14Myocardial infarction (HP:0001658)3.81408409
15Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.62996264
16* Abnormality of mucopolysaccharide metabolism (HP:0011020)3.57389932
17* Abnormality of polysaccharide metabolism (HP:0011012)3.57389932
18* Abnormality of glycosaminoglycan metabolism (HP:0004371)3.57389932
19Joint stiffness (HP:0001387)3.53882986
20Premature rupture of membranes (HP:0001788)3.38475083
21Protrusio acetabuli (HP:0003179)3.36525299
22Coronal craniosynostosis (HP:0004440)3.30299100
23Abnormal hemoglobin (HP:0011902)3.16634147
24Concave nail (HP:0001598)3.13889347
25Asymmetric septal hypertrophy (HP:0001670)3.13227850
26Hypochromic microcytic anemia (HP:0004840)3.12281732
27Vertebral compression fractures (HP:0002953)3.06561391
28Rib fusion (HP:0000902)3.04448653
29Loss of speech (HP:0002371)3.01625408
30Polycythemia (HP:0001901)2.93944208
31Facial hemangioma (HP:0000329)2.83649465
32Vaginal fistula (HP:0004320)2.82233415
33Growth hormone excess (HP:0000845)2.79973419
34Male infertility (HP:0003251)2.76391460
35Sparse lateral eyebrow (HP:0005338)2.74137123
36Rectal fistula (HP:0100590)2.73244365
37Rectovaginal fistula (HP:0000143)2.73244365
38Poikiloderma (HP:0001029)2.69152717
39Natal tooth (HP:0000695)2.67907425
40Abnormality of the renal cortex (HP:0011035)2.67549157
41Annular pancreas (HP:0001734)2.62691722
42Short humerus (HP:0005792)2.61898185
43Tubulointerstitial fibrosis (HP:0005576)2.54388470
44Bowing of the arm (HP:0006488)2.51908357
45Bowed forearm bones (HP:0003956)2.51908357
46Premature skin wrinkling (HP:0100678)2.51380313
47Cervical subluxation (HP:0003308)2.50746755
48Albinism (HP:0001022)2.48883912
49Pancreatic cysts (HP:0001737)2.48845497
50Tubular atrophy (HP:0000092)2.44955940
51Ketoacidosis (HP:0001993)2.44163301
52Vacuolated lymphocytes (HP:0001922)2.43297294
53Increased cerebral lipofuscin (HP:0011813)2.43117306
54Orthostatic hypotension (HP:0001278)2.42510428
55Dysautonomia (HP:0002459)2.41621008
56Large for gestational age (HP:0001520)2.40192216
57Hematochezia (HP:0002573)2.38864100
58Generalized amyotrophy (HP:0003700)2.37958651
59Intestinal fistula (HP:0100819)2.37834000
60Osteolytic defects of the hand bones (HP:0009699)2.36033096
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.36033096
62Blue sclerae (HP:0000592)2.34784772
63Hypokinesia (HP:0002375)2.33093428
64Congenital sensorineural hearing impairment (HP:0008527)2.32589024
65Atrophic scars (HP:0001075)2.30554977
66Abnormality of the distal phalanges of the toes (HP:0010182)2.30021107
67Hypercortisolism (HP:0001578)2.28670642
68Hypochromic anemia (HP:0001931)2.27841790
69Aplasia/hypoplasia of the humerus (HP:0006507)2.26584164
70Prolonged neonatal jaundice (HP:0006579)2.25386174
71Lip pit (HP:0100267)2.25145623
72Nephritis (HP:0000123)2.25031376
73Systemic lupus erythematosus (HP:0002725)2.23866817
74Xanthomatosis (HP:0000991)2.20209237
75Ovoid vertebral bodies (HP:0003300)2.18054067
76Pancreatic islet-cell hyperplasia (HP:0004510)2.17679472
77Mitral stenosis (HP:0001718)2.17465541
78Complement deficiency (HP:0004431)2.15395490
79Cardiovascular calcification (HP:0011915)2.13905696
80Abnormality of male internal genitalia (HP:0000022)2.13512088
81Diaphragmatic weakness (HP:0009113)2.13376214
82Abnormality of complement system (HP:0005339)2.12560967
83Hypoplastic ischia (HP:0003175)2.11216412
84Tubulointerstitial abnormality (HP:0001969)2.10228252
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10000346
86Tongue fasciculations (HP:0001308)2.08155800
87Follicular hyperkeratosis (HP:0007502)2.07478827
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07102575
89Muscle fibrillation (HP:0010546)2.05845514
90Increased neuronal autofluorescent lipopigment (HP:0002074)2.05316355
91Hydroxyprolinuria (HP:0003080)2.04977819
92Abnormality of proline metabolism (HP:0010907)2.04977819
93Axonal loss (HP:0003447)2.04537392
94Clumsiness (HP:0002312)2.02922465
95Increased corneal curvature (HP:0100692)2.02887007
96Keratoconus (HP:0000563)2.02887007
97Congenital hip dislocation (HP:0001374)2.00816380
98Prostate neoplasm (HP:0100787)2.00760533
99Exocrine pancreatic insufficiency (HP:0001738)1.99240372
100Spondylolisthesis (HP:0003302)1.98400078
101Metaphyseal cupping (HP:0003021)1.98251812
102Aneurysm (HP:0002617)1.98006450
103Mesangial abnormality (HP:0001966)1.95779086
104Abnormal enzyme/coenzyme activity (HP:0012379)1.94889621
105Genu recurvatum (HP:0002816)1.93364597
106Abnormality of the ischium (HP:0003174)1.92611305
107Bilateral sensorineural hearing impairment (HP:0008619)1.92578501
108Aortic aneurysm (HP:0004942)1.91379472
109Abnormality of alkaline phosphatase activity (HP:0004379)1.91217228
110Tetraparesis (HP:0002273)1.91097762
111Multiple lipomas (HP:0001012)1.90852068
112Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89947988
113Choanal stenosis (HP:0000452)1.89497556
114Hypoplasia of the odontoid process (HP:0003311)1.89203177
115Intrahepatic cholestasis (HP:0001406)1.88092916
116Renal cortical cysts (HP:0000803)1.87964333
117Abnormal protein glycosylation (HP:0012346)1.86970732
118Abnormal glycosylation (HP:0012345)1.86970732
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86970732
120Abnormal protein N-linked glycosylation (HP:0012347)1.86970732
121Aortic dissection (HP:0002647)1.86470292
122Elbow flexion contracture (HP:0002987)1.85815807
123Vascular calcification (HP:0004934)1.85089749
124Hyperextensible skin (HP:0000974)1.83805635
125Short chin (HP:0000331)1.83054018
126IgA deficiency (HP:0002720)1.82324807
127Bifid uvula (HP:0000193)1.80758586
128Ankle contracture (HP:0006466)1.79752247
129Bile duct proliferation (HP:0001408)1.79712124
130Abnormal biliary tract physiology (HP:0012439)1.79712124
131Ketosis (HP:0001946)1.79665222
132Progressive visual loss (HP:0000529)1.79264019
133Glomerulonephritis (HP:0000099)1.78882272
134Retinal atrophy (HP:0001105)1.78811611
135Disproportionate short-trunk short stature (HP:0003521)1.78687847
136Soft skin (HP:0000977)1.78474321
137Poor head control (HP:0002421)1.78446655
138Facial diplegia (HP:0001349)1.78427845
139Cardiomegaly (HP:0001640)1.77677503
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77666917
141Congenital glaucoma (HP:0001087)1.77293866
142Deep venous thrombosis (HP:0002625)1.76607595
143Short 5th finger (HP:0009237)1.75566197
144Narrow nasal bridge (HP:0000446)1.75284437
145Increased mean platelet volume (HP:0011877)1.74992579
146Abnormality of endocrine pancreas physiology (HP:0012093)1.73414674
147Abolished electroretinogram (ERG) (HP:0000550)1.72644890
148Aortic valve stenosis (HP:0001650)1.72129063
149Glucose intolerance (HP:0000833)1.71701935
150Abnormality of transition element cation homeostasis (HP:0011030)1.71615297
151Opisthotonus (HP:0002179)1.71488741
152Amelogenesis imperfecta (HP:0000705)1.70992637
153Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.70768339
154Ectropion (HP:0000656)1.70579093
155Potter facies (HP:0002009)1.69761764
156Facial shape deformation (HP:0011334)1.69761764
157Peritonitis (HP:0002586)1.68599744
158Depressed nasal tip (HP:0000437)1.67530051
159Severe visual impairment (HP:0001141)1.66361734
160Beaking of vertebral bodies (HP:0004568)1.66179905
161Popliteal pterygium (HP:0009756)1.64961912
162Abnormal glucose tolerance (HP:0001952)1.64749875
163Amyloidosis (HP:0011034)1.64537790
164Vascular tortuosity (HP:0004948)1.63500614
165* Progressive neurologic deterioration (HP:0002344)1.61152426
166Abnormality of the pericardium (HP:0001697)1.61018774
167Abnormality of macrophages (HP:0004311)1.60857796
168Proximal tubulopathy (HP:0000114)1.60170228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.12098776
2DDR25.28558340
3ICK4.33917414
4MAP3K63.53040998
5STK242.93662978
6MAP3K112.87890231
7STK392.86485248
8PDGFRA2.72582347
9ACVR1B2.55210844
10CSK2.52955789
11FER2.49714097
12TIE12.47130257
13FGR2.42291934
14MATK2.37071447
15PIM22.36879542
16BMX2.35659421
17PINK12.21298840
18ERN12.20010584
19WNK42.19823137
20TRIB32.16266945
21DYRK1B2.03469783
22PRKD21.96735571
23TYRO31.85910677
24MYLK1.83801135
25BMPR1B1.83728256
26ADRBK21.81481572
27GRK11.77351208
28TRPM71.74688225
29CCNB11.55089103
30PIK3CG1.48630451
31CDK61.46187753
32DAPK11.42724318
33ZAK1.41845241
34SIK11.31416643
35YES11.29974746
36UHMK11.27586340
37EPHA21.24782796
38PIM11.23707117
39NEK91.23361044
40GSK3A1.21172824
41LATS11.16699367
42LATS21.13255940
43TESK11.12838079
44MUSK1.10612429
45ILK1.04278067
46PTK2B1.00308721
47RPS6KC10.99953350
48RPS6KL10.99953350
49MAPK110.99589442
50LIMK10.99471390
51HIPK20.98951642
52RIPK10.96685496
53MAP4K20.96569711
54ADRBK10.95965799
55BMPR20.95885121
56FLT30.95702945
57TAOK30.93814633
58TGFBR20.93149547
59CDC42BPA0.91239802
60TGFBR10.91017288
61RPS6KA60.90652504
62GRK70.88944432
63CSF1R0.87793659
64CAMKK20.86761668
65PRKCE0.86375036
66PTK20.85746621
67EEF2K0.84994623
68PDGFRB0.82605037
69STK30.82394013
70CDK70.80523073
71MAP3K100.77840425
72SCYL20.76150662
73MTOR0.75772904
74NME20.74759563
75TBK10.70049708
76MST1R0.69668260
77CSNK1A1L0.67732188
78TEC0.64447998
79OXSR10.63438620
80IKBKB0.63108013
81MAP2K10.62897783
82MAP3K30.62769567
83AKT30.62677528
84ERBB30.62472158
85FRK0.62233678
86PRKAA10.62067462
87CSNK1G30.61721722
88EGFR0.61650764
89TYK20.61045117
90RPS6KA20.60582954
91PTK60.57495725
92CHUK0.57186106
93MAPKAPK50.57046366
94PAK20.56671922
95GRK60.56257231
96PBK0.56147051
97MAP3K120.54708615
98PRKAA20.54481227
99JAK20.54318520
100INSRR0.53670708
101TTN0.53601773
102PRKCQ0.53542982
103IRAK10.53128647
104MST40.52485270
105MAPKAPK30.52381419
106TNK20.51760255
107TAOK20.51264010
108CSNK1G10.50852781
109FGFR40.49600705
110BCKDK0.49543595
111RPS6KA10.49300820
112PKN20.49030596
113INSR0.47428752
114PHKG20.46948601
115PHKG10.46948601
116DMPK0.46946835
117LYN0.45963720
118JAK10.45078949
119IKBKE0.44887672
120ABL10.44104406
121STK38L0.43841121
122MAP3K140.42979049
123MAP2K60.42422376
124CAMK1D0.42120967
125PIK3CA0.42005255
126CDK120.40950178
127MAP3K20.40226466
128IGF1R0.39889444
129CAMK40.39106694
130CAMK10.39083025
131STK100.38886116
132EPHA30.38568820
133IRAK30.38443866
134MAPKAPK20.38223066
135HCK0.37791978
136NUAK10.36678563
137JAK30.36369434
138PRKG20.35639285
139MET0.35279733
140EPHB10.35172852
141WNK10.34429452
142MAPK30.33751836
143BLK0.32947967
144PAK40.32823229
145PRKD10.32344185
146MAPK10.32043444
147MAP2K20.29979832
148MAPK40.25293650
149NTRK10.24816572
150PRPF4B0.24679146
151ABL20.24424436
152STK380.24080977
153LCK0.23925077
154ZAP700.23907257
155RAF10.23695084
156PRKCD0.23294677
157KIT0.22958150

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.35338026
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.94185001
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.80094669
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30068144
5Sphingolipid metabolism_Homo sapiens_hsa006002.14470575
6* Lysosome_Homo sapiens_hsa041422.09361738
7Arginine biosynthesis_Homo sapiens_hsa002201.97385837
8Fatty acid metabolism_Homo sapiens_hsa012121.96685315
9Staphylococcus aureus infection_Homo sapiens_hsa051501.94347333
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.91672793
11Arginine and proline metabolism_Homo sapiens_hsa003301.86691306
12Butanoate metabolism_Homo sapiens_hsa006501.79037054
13Adherens junction_Homo sapiens_hsa045201.64728170
14Bladder cancer_Homo sapiens_hsa052191.64625344
15Folate biosynthesis_Homo sapiens_hsa007901.64550783
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64526351
17mTOR signaling pathway_Homo sapiens_hsa041501.63693639
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.63026138
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59122518
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57845612
21Complement and coagulation cascades_Homo sapiens_hsa046101.57043362
22Nitrogen metabolism_Homo sapiens_hsa009101.56630257
23Chemical carcinogenesis_Homo sapiens_hsa052041.53637999
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47932909
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47624485
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46416125
27Other glycan degradation_Homo sapiens_hsa005111.45525645
28Base excision repair_Homo sapiens_hsa034101.42730157
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.40130963
30Sulfur relay system_Homo sapiens_hsa041221.37604634
31beta-Alanine metabolism_Homo sapiens_hsa004101.36279038
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36003378
33Legionellosis_Homo sapiens_hsa051341.34461404
34Rheumatoid arthritis_Homo sapiens_hsa053231.30141697
35Lysine degradation_Homo sapiens_hsa003101.27314803
36Tryptophan metabolism_Homo sapiens_hsa003801.26790192
37Shigellosis_Homo sapiens_hsa051311.26017133
38Longevity regulating pathway - mammal_Homo sapiens_hsa042111.25462289
39TGF-beta signaling pathway_Homo sapiens_hsa043501.25338613
40Circadian rhythm_Homo sapiens_hsa047101.23761662
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22655528
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19278025
43Retinol metabolism_Homo sapiens_hsa008301.18253977
44Arachidonic acid metabolism_Homo sapiens_hsa005901.16116729
45Notch signaling pathway_Homo sapiens_hsa043301.16052693
46Fatty acid elongation_Homo sapiens_hsa000621.10906214
47Hippo signaling pathway_Homo sapiens_hsa043901.10379140
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.05751996
49Selenocompound metabolism_Homo sapiens_hsa004501.05226855
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05041006
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03783659
52Asthma_Homo sapiens_hsa053101.03246391
53Glutathione metabolism_Homo sapiens_hsa004801.02738539
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01107690
55Caffeine metabolism_Homo sapiens_hsa002321.00708625
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.00510124
57p53 signaling pathway_Homo sapiens_hsa041151.00445741
58Starch and sucrose metabolism_Homo sapiens_hsa005000.99352779
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99296190
60Fatty acid degradation_Homo sapiens_hsa000710.98117166
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.97834054
62Focal adhesion_Homo sapiens_hsa045100.97668955
63PPAR signaling pathway_Homo sapiens_hsa033200.97559837
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97229813
65Chronic myeloid leukemia_Homo sapiens_hsa052200.94716844
66Prion diseases_Homo sapiens_hsa050200.93148766
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92319850
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92069112
69Hedgehog signaling pathway_Homo sapiens_hsa043400.91017284
70Proteoglycans in cancer_Homo sapiens_hsa052050.90661385
71Phagosome_Homo sapiens_hsa041450.90493810
72Biosynthesis of amino acids_Homo sapiens_hsa012300.90115775
73Small cell lung cancer_Homo sapiens_hsa052220.86958680
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86800058
75Phototransduction_Homo sapiens_hsa047440.85325378
76Mismatch repair_Homo sapiens_hsa034300.84249492
77Glycerolipid metabolism_Homo sapiens_hsa005610.84108392
78Tyrosine metabolism_Homo sapiens_hsa003500.82145912
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80423501
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80088147
81Leishmaniasis_Homo sapiens_hsa051400.79869502
82Linoleic acid metabolism_Homo sapiens_hsa005910.79802936
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78227999
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76476201
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73499432
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73045891
87ABC transporters_Homo sapiens_hsa020100.72331421
88ECM-receptor interaction_Homo sapiens_hsa045120.70233498
89Viral myocarditis_Homo sapiens_hsa054160.70179176
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68367831
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67546643
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67024274
93Graft-versus-host disease_Homo sapiens_hsa053320.66838719
94Galactose metabolism_Homo sapiens_hsa000520.66460561
95Ether lipid metabolism_Homo sapiens_hsa005650.66037353
96Fat digestion and absorption_Homo sapiens_hsa049750.64390490
97AMPK signaling pathway_Homo sapiens_hsa041520.64355876
98VEGF signaling pathway_Homo sapiens_hsa043700.64324070
99Amoebiasis_Homo sapiens_hsa051460.63857799
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63436934
101Ovarian steroidogenesis_Homo sapiens_hsa049130.63046955
102Toxoplasmosis_Homo sapiens_hsa051450.62037770
103Dorso-ventral axis formation_Homo sapiens_hsa043200.61844028
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61625861
105Allograft rejection_Homo sapiens_hsa053300.61600277
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61236691
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.60806743
108Mineral absorption_Homo sapiens_hsa049780.60427598
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60095399
110MicroRNAs in cancer_Homo sapiens_hsa052060.59842590
111Steroid biosynthesis_Homo sapiens_hsa001000.59638855
112Tuberculosis_Homo sapiens_hsa051520.59510628
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.59138073
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59034699
115Propanoate metabolism_Homo sapiens_hsa006400.58873682
116Malaria_Homo sapiens_hsa051440.57506923
117Bile secretion_Homo sapiens_hsa049760.56711942
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55649346
119Insulin resistance_Homo sapiens_hsa049310.54883040
120Pancreatic cancer_Homo sapiens_hsa052120.54060376
121Phenylalanine metabolism_Homo sapiens_hsa003600.53340948
122Osteoclast differentiation_Homo sapiens_hsa043800.52761781
123Platelet activation_Homo sapiens_hsa046110.52423965
124Fructose and mannose metabolism_Homo sapiens_hsa000510.51982260
125Apoptosis_Homo sapiens_hsa042100.51337243
126Salivary secretion_Homo sapiens_hsa049700.50790964
127Insulin signaling pathway_Homo sapiens_hsa049100.50706328
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50226181
129Autoimmune thyroid disease_Homo sapiens_hsa053200.49713375
130Collecting duct acid secretion_Homo sapiens_hsa049660.49391978
131Histidine metabolism_Homo sapiens_hsa003400.48222683
132Peroxisome_Homo sapiens_hsa041460.47439997
133Renin-angiotensin system_Homo sapiens_hsa046140.46795276
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46574219
135Acute myeloid leukemia_Homo sapiens_hsa052210.46399322
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45403836
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44595272
138Type I diabetes mellitus_Homo sapiens_hsa049400.44439227
139N-Glycan biosynthesis_Homo sapiens_hsa005100.44331995
140Hepatitis B_Homo sapiens_hsa051610.43772795
141Prostate cancer_Homo sapiens_hsa052150.42977184
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.42242182
143Protein digestion and absorption_Homo sapiens_hsa049740.41402506
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.41381573
145Hematopoietic cell lineage_Homo sapiens_hsa046400.41349415
146Pertussis_Homo sapiens_hsa051330.38466931
147TNF signaling pathway_Homo sapiens_hsa046680.37247029
148Measles_Homo sapiens_hsa051620.37228131
149Metabolic pathways_Homo sapiens_hsa011000.36927881
150B cell receptor signaling pathway_Homo sapiens_hsa046620.34969824
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.34596550
152Sulfur metabolism_Homo sapiens_hsa009200.34554564
153Vibrio cholerae infection_Homo sapiens_hsa051100.34446111
154Hepatitis C_Homo sapiens_hsa051600.32844351
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31444545
156Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30758223

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