SUMO1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)7.68603476
2sperm motility (GO:0030317)7.60644558
3acrosome reaction (GO:0007340)7.40866671
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.20672175
5sperm capacitation (GO:0048240)5.95262807
6chromosome condensation (GO:0030261)5.91301558
7protein targeting to Golgi (GO:0000042)5.83004631
8DNA packaging (GO:0006323)5.78761943
9plasma membrane fusion (GO:0045026)5.65278000
10detection of molecule of bacterial origin (GO:0032490)5.64943291
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.63284662
12positive regulation by organism of defense response of other organism involved in symbiotic interact5.63284662
13modulation by symbiont of host immune response (GO:0052553)5.63284662
14positive regulation by symbiont of host defense response (GO:0052509)5.63284662
15modulation by symbiont of host defense response (GO:0052031)5.63284662
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.63284662
17establishment of protein localization to Golgi (GO:0072600)5.53043367
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.44994250
19retrograde transport, vesicle recycling within Golgi (GO:0000301)5.42958653
20response to pheromone (GO:0019236)5.22169483
21microtubule depolymerization (GO:0007019)5.15704999
22single strand break repair (GO:0000012)5.08603269
23spermatid nucleus differentiation (GO:0007289)5.02729227
24regulation of interferon-beta biosynthetic process (GO:0045357)5.00415105
25negative regulation of inclusion body assembly (GO:0090084)4.98005087
26spermatid development (GO:0007286)4.89116580
27motile cilium assembly (GO:0044458)4.86785144
28cellular extravasation (GO:0045123)4.84454670
29phosphatidylethanolamine biosynthetic process (GO:0006646)4.81723799
30macrophage activation involved in immune response (GO:0002281)4.81154170
31sperm-egg recognition (GO:0035036)4.71320171
32rRNA methylation (GO:0031167)4.49793133
33multicellular organism reproduction (GO:0032504)4.47540985
34phosphatidylethanolamine metabolic process (GO:0046337)4.47525298
35centriole assembly (GO:0098534)4.35818861
36regulation of T-helper 2 cell differentiation (GO:0045628)4.30041562
37sexual reproduction (GO:0019953)4.27164386
38reproduction (GO:0000003)4.25430924
39spermatogenesis (GO:0007283)4.22956699
40male gamete generation (GO:0048232)4.21154813
41microtubule polymerization or depolymerization (GO:0031109)4.20288164
42binding of sperm to zona pellucida (GO:0007339)4.18607268
43cell wall macromolecule catabolic process (GO:0016998)4.15248924
44protein polyglutamylation (GO:0018095)4.13634422
45cell-cell recognition (GO:0009988)4.01834944
46detection of external biotic stimulus (GO:0098581)4.01555766
47RNA destabilization (GO:0050779)4.00540715
48neutrophil mediated immunity (GO:0002446)3.94963802
49protein localization to Golgi apparatus (GO:0034067)3.94317500
50centriole replication (GO:0007099)3.93489362
51microglial cell activation (GO:0001774)3.91412653
52macrophage activation (GO:0042116)3.88248094
53gamete generation (GO:0007276)3.82304811
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.81815087
55calcium ion-dependent exocytosis (GO:0017156)3.79529801
56cell wall macromolecule metabolic process (GO:0044036)3.72155005
57axonemal dynein complex assembly (GO:0070286)3.66482006
58detection of other organism (GO:0098543)3.65665205
59neutrophil activation involved in immune response (GO:0002283)3.65644254
60regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.64694546
61response to host immune response (GO:0052572)3.64320553
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.64320553
63detection of biotic stimulus (GO:0009595)3.61142812
64positive regulation of Rab GTPase activity (GO:0032851)3.58742461
65regulation of Rab GTPase activity (GO:0032313)3.58742461
66rRNA modification (GO:0000154)3.58111984
67negative regulation of Rho protein signal transduction (GO:0035024)3.57865928
68response to peptidoglycan (GO:0032494)3.56214498
69myeloid cell activation involved in immune response (GO:0002275)3.51135599
70positive regulation of gamma-delta T cell activation (GO:0046645)3.38651511
71neutrophil activation (GO:0042119)3.33669124
72positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.30873497
73microtubule severing (GO:0051013)3.28706678
74negative regulation of cell killing (GO:0031342)3.28237537
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28237537
76response to host (GO:0075136)3.21545430
77response to host defenses (GO:0052200)3.21545430
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21545430
79cilium or flagellum-dependent cell motility (GO:0001539)3.19399987
80regulation of B cell receptor signaling pathway (GO:0050855)3.18009890
81single fertilization (GO:0007338)3.17356526
82production of molecular mediator involved in inflammatory response (GO:0002532)3.16910097
83regulation of inclusion body assembly (GO:0090083)3.15477784
84myeloid leukocyte mediated immunity (GO:0002444)3.15085496
85chromatin silencing (GO:0006342)3.14441457
86regulation of gamma-delta T cell activation (GO:0046643)3.14341413
87seminiferous tubule development (GO:0072520)3.10214723
88multicellular organismal reproductive process (GO:0048609)3.06772786
89negative regulation of interleukin-12 production (GO:0032695)3.05485931
90I-kappaB phosphorylation (GO:0007252)3.02633123
91respiratory burst (GO:0045730)2.99002734
92regulation of gamma-delta T cell differentiation (GO:0045586)2.98669851
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.97595564
94leukocyte degranulation (GO:0043299)2.96786040
95regulation of centriole replication (GO:0046599)2.93971720
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.91771071
97granulocyte activation (GO:0036230)2.90534457
98histone H3-K9 demethylation (GO:0033169)2.90500794
99leukocyte migration involved in inflammatory response (GO:0002523)2.88473792
100regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85261786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.92614301
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.81775223
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.06155380
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.92165489
5* RUNX_20019798_ChIP-Seq_JUKART_Human2.50748143
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29281161
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.27790173
8VDR_24787735_ChIP-Seq_THP-1_Human2.24984533
9SPI1_23127762_ChIP-Seq_K562_Human2.20484234
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14467743
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08952237
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.08952237
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.04859752
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97747439
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81273833
16VDR_24763502_ChIP-Seq_THP-1_Human1.77107592
17* MYB_26560356_Chip-Seq_TH2_Human1.68082332
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67252598
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66067555
20BCL6_27268052_Chip-Seq_Bcells_Human1.65279227
21* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64802654
22ELF1_20517297_ChIP-Seq_JURKAT_Human1.63973617
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52334753
24CBP_20019798_ChIP-Seq_JUKART_Human1.52334753
25* SPI1_23547873_ChIP-Seq_NB4_Human1.50515914
26* RAC3_21632823_ChIP-Seq_H3396_Human1.49620447
27BCOR_27268052_Chip-Seq_Bcells_Human1.48015759
28* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47968228
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46923660
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46695108
31RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45998059
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43931406
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42613835
34ERA_21632823_ChIP-Seq_H3396_Human1.42180361
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41981637
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41129059
37NANOG_20526341_ChIP-Seq_ESCs_Human1.39040809
38* ER_23166858_ChIP-Seq_MCF-7_Human1.38552841
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37986198
40KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.35575014
41SMRT_27268052_Chip-Seq_Bcells_Human1.33916717
42GATA3_27048872_Chip-Seq_THYMUS_Human1.31893343
43GATA3_26560356_Chip-Seq_TH2_Human1.29259669
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28066045
45* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27672900
46E2F1_20622854_ChIP-Seq_HELA_Human1.27376868
47SCL_19346495_ChIP-Seq_HPC-7_Human1.26638475
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25319789
49DROSHA_22980978_ChIP-Seq_HELA_Human1.24721733
50P300_27268052_Chip-Seq_Bcells_Human1.23803342
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23519206
52* MYB_26560356_Chip-Seq_TH1_Human1.23355952
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23062045
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20637064
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18501376
56EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.18125704
57OCT4_20526341_ChIP-Seq_ESCs_Human1.17670470
58SALL4_22934838_ChIP-ChIP_CD34+_Human1.17428099
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16194948
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16193791
61WDR5_24793694_ChIP-Seq_LNCAP_Human1.14650507
62SPI1_20517297_ChIP-Seq_HL60_Human1.14116165
63MAF_26560356_Chip-Seq_TH1_Human1.13092760
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12116746
65CEBPB_22108803_ChIP-Seq_LS180_Human1.10587965
66LXR_22292898_ChIP-Seq_THP-1_Human1.10026849
67TAF2_19829295_ChIP-Seq_ESCs_Human1.09600624
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09434397
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08966307
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08146985
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.07738227
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07322774
73ERG_20517297_ChIP-Seq_VCAP_Human1.07320668
74TCF7_22412390_ChIP-Seq_EML_Mouse1.07318192
75GATA1_19941826_ChIP-Seq_K562_Human1.05583487
76UTX_26944678_Chip-Seq_JUKART_Human1.05036823
77* MYC_19829295_ChIP-Seq_ESCs_Human1.04829598
78PHF8_20622854_ChIP-Seq_HELA_Human1.04439491
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04311015
80SMC4_20622854_ChIP-Seq_HELA_Human1.03978901
81P68_20966046_ChIP-Seq_HELA_Human1.03118620
82CBX2_22325352_ChIP-Seq_293T-Rex_Human1.02904101
83TP63_22573176_ChIP-Seq_HFKS_Human1.02801803
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02702812
85* ARNT_22903824_ChIP-Seq_MCF-7_Human1.02656277
86* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02342917
87CTCF_20526341_ChIP-Seq_ESCs_Human1.02001823
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01862218
89HNFA_21074721_ChIP-Seq_CACO-2_Human1.01746591
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00670293
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00569324
92STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99670763
93RBPJ_21746931_ChIP-Seq_IB4_Human0.99169829
94P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.99013468
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98057605
96* GATA3_21878914_ChIP-Seq_MCF-7_Human0.97419894
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96334545
98GATA3_26560356_Chip-Seq_TH1_Human0.95741341
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95566396
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94975451

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.72101231
2MP0003724_increased_susceptibility_to4.59035089
3MP0005377_hearing/vestibular/ear_phenot3.96665812
4MP0003878_abnormal_ear_physiology3.96665812
5MP0005451_abnormal_body_composition3.69635911
6MP0002132_abnormal_respiratory_system3.61115078
7MP0003436_decreased_susceptibility_to3.07541348
8MP0003303_peritoneal_inflammation2.78619517
9MP0001835_abnormal_antigen_presentation2.70008188
10MP0003698_abnormal_male_reproductive2.58020100
11MP0002419_abnormal_innate_immunity2.43611413
12MP0001929_abnormal_gametogenesis2.22082231
13MP0005670_abnormal_white_adipose2.08667038
14MP0009785_altered_susceptibility_to2.06773705
15MP0005025_abnormal_response_to1.96603541
16MP0009278_abnormal_bone_marrow1.88776702
17MP0005310_abnormal_salivary_gland1.86017170
18MP0001800_abnormal_humoral_immune1.79309405
19MP0002723_abnormal_immune_serum1.79076352
20MP0000569_abnormal_digit_pigmentation1.78967515
21MP0003828_pulmonary_edema1.77741386
22MP0009764_decreased_sensitivity_to1.75473428
23MP0006082_CNS_inflammation1.75239904
24MP0008260_abnormal_autophagy1.74499534
25MP0001533_abnormal_skeleton_physiology1.73336640
26MP0005397_hematopoietic_system_phenotyp1.71815071
27MP0001545_abnormal_hematopoietic_system1.71815071
28MP0003172_abnormal_lysosome_physiology1.71595566
29MP0001348_abnormal_lacrimal_gland1.68396080
30MP0004510_myositis1.66793772
31MP0005000_abnormal_immune_tolerance1.66132513
32MP0000678_abnormal_parathyroid_gland1.64549007
33MP0002452_abnormal_antigen_presenting1.63920696
34MP0002420_abnormal_adaptive_immunity1.56877462
35MP0001819_abnormal_immune_cell1.54939271
36MP0000685_abnormal_immune_system1.45549928
37MP0005671_abnormal_response_to1.38824661
38MP0003191_abnormal_cellular_cholesterol1.38548725
39MP0005164_abnormal_response_to1.33121520
40MP0003646_muscle_fatigue1.32687706
41MP0004883_abnormal_blood_vessel1.32509467
42MP0002161_abnormal_fertility/fecundity1.29258392
43MP0003011_delayed_dark_adaptation1.27883842
44MP0001790_abnormal_immune_system1.22682661
45MP0005387_immune_system_phenotype1.22682661
46MP0002405_respiratory_system_inflammati1.15829936
47MP0004484_altered_response_of1.12769064
48MP0000716_abnormal_immune_system1.12579639
49MP0005464_abnormal_platelet_physiology1.10426974
50MP0005166_decreased_susceptibility_to1.10392088
51MP0002398_abnormal_bone_marrow1.09872596
52MP0008877_abnormal_DNA_methylation1.09325132
53MP0001845_abnormal_inflammatory_respons1.09129736
54MP0004947_skin_inflammation1.08028490
55MP0002722_abnormal_immune_system1.05274695
56MP0002148_abnormal_hypersensitivity_rea1.04242036
57MP0003075_altered_response_to1.04035305
58MP0004381_abnormal_hair_follicle1.03287314
59MP0008004_abnormal_stomach_pH1.02875097
60MP0001765_abnormal_ion_homeostasis1.02252374
61MP0008469_abnormal_protein_level1.01770764
62MP0002138_abnormal_hepatobiliary_system0.98687074
63MP0005248_abnormal_Harderian_gland0.98324077
64MP0002277_abnormal_respiratory_mucosa0.93786899
65MP0009115_abnormal_fat_cell0.93260350
66MP0004742_abnormal_vestibular_system0.89645324
67MP0000689_abnormal_spleen_morphology0.86531480
68MP0002396_abnormal_hematopoietic_system0.85915907
69MP0000703_abnormal_thymus_morphology0.85116857
70MP0002166_altered_tumor_susceptibility0.85034798
71MP0002429_abnormal_blood_cell0.85021476
72MP0003300_gastrointestinal_ulcer0.80426736
73MP0005167_abnormal_blood-brain_barrier0.79594766
74MP0002998_abnormal_bone_remodeling0.78667001
75MP0002282_abnormal_trachea_morphology0.78300078
76MP0000249_abnormal_blood_vessel0.76710530
77MP0000015_abnormal_ear_pigmentation0.75750392
78MP0000604_amyloidosis0.74377358
79MP0001486_abnormal_startle_reflex0.73395063
80MP0009053_abnormal_anal_canal0.72625261
81MP0002332_abnormal_exercise_endurance0.68953563
82MP0009765_abnormal_xenobiotic_induced0.68538091
83MP0002210_abnormal_sex_determination0.66511628
84MP0003787_abnormal_imprinting0.66016453
85MP0001145_abnormal_male_reproductive0.65656865
86MP0002928_abnormal_bile_duct0.65484807
87MP0000465_gastrointestinal_hemorrhage0.65374286
88MP0000470_abnormal_stomach_morphology0.64272535
89MP0005379_endocrine/exocrine_gland_phen0.62998827
90MP0008874_decreased_physiological_sensi0.60719910
91MP0001485_abnormal_pinna_reflex0.60151817
92MP0002127_abnormal_cardiovascular_syste0.59902345
93MP0005535_abnormal_body_temperature0.59523069
94MP0003866_abnormal_defecation0.58867025
95MP0001851_eye_inflammation0.58274926
96MP0002006_tumorigenesis0.58271515
97MP0000653_abnormal_sex_gland0.58270574
98MP0005423_abnormal_somatic_nervous0.57674441
99MP0000681_abnormal_thyroid_gland0.56397702
100MP0003448_altered_tumor_morphology0.56068085

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)6.25762368
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.44857691
3Absent/shortened dynein arms (HP:0200106)5.23979183
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.23979183
5Retrobulbar optic neuritis (HP:0100654)5.21035777
6Optic neuritis (HP:0100653)5.21035777
7Orchitis (HP:0100796)5.14995067
8Myositis (HP:0100614)4.96677287
9Recurrent bacterial skin infections (HP:0005406)4.78737102
10Recurrent abscess formation (HP:0002722)4.66415305
11Resting tremor (HP:0002322)4.62337864
12Gastrointestinal infarctions (HP:0005244)4.24755000
13Gingivitis (HP:0000230)4.09899772
14Asymmetric septal hypertrophy (HP:0001670)4.04870929
15Eczematoid dermatitis (HP:0000976)4.04157288
16Nasal polyposis (HP:0100582)3.72625857
17Keratoconjunctivitis sicca (HP:0001097)3.70236032
18Elevated erythrocyte sedimentation rate (HP:0003565)3.64127266
19Stomatitis (HP:0010280)3.59559463
20Abnormality of macrophages (HP:0004311)3.59408157
21Peritonitis (HP:0002586)3.57860631
22Recurrent gram-negative bacterial infections (HP:0005420)3.55681473
23Attenuation of retinal blood vessels (HP:0007843)3.45110169
24Keratoconjunctivitis (HP:0001096)3.39564868
25Abnormal ciliary motility (HP:0012262)3.39222813
26Obstructive lung disease (HP:0006536)3.25853252
27Chronic obstructive pulmonary disease (HP:0006510)3.25853252
28Cone-rod dystrophy (HP:0000548)3.16964166
29Bony spicule pigmentary retinopathy (HP:0007737)3.16671939
30Abnormal respiratory motile cilium physiology (HP:0012261)3.15289842
31Tubulointerstitial nephritis (HP:0001970)3.14084988
32Abnormal respiratory epithelium morphology (HP:0012253)3.13178366
33Abnormal respiratory motile cilium morphology (HP:0005938)3.13178366
34Postural instability (HP:0002172)3.07515767
35Recurrent skin infections (HP:0001581)3.06193624
36Abnormal rod and cone electroretinograms (HP:0008323)2.96226781
37Abnormality of the nasal mucosa (HP:0000433)2.92247782
38Arterial thrombosis (HP:0004420)2.90078801
39Chronic hepatic failure (HP:0100626)2.82635670
40Recurrent fungal infections (HP:0002841)2.74930634
41Tetany (HP:0001281)2.72976675
42Male infertility (HP:0003251)2.72050419
43Episodic fever (HP:0001954)2.71722455
44Amyloidosis (HP:0011034)2.69709445
45Abnormality of macular pigmentation (HP:0008002)2.65566345
46Hypoplasia of the thymus (HP:0000778)2.63277253
47Meningitis (HP:0001287)2.63199543
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60422784
49Hemoptysis (HP:0002105)2.60030987
50Chest pain (HP:0100749)2.58566425
51Aplasia/Hypoplasia of the earlobes (HP:0009906)2.54172576
52Encephalitis (HP:0002383)2.53546928
53Hyperkalemia (HP:0002153)2.53397539
54Infertility (HP:0000789)2.52980387
55Progressive sensorineural hearing impairment (HP:0000408)2.51756363
56Enlarged epiphyses (HP:0010580)2.50179744
57Impulsivity (HP:0100710)2.43702268
58Recurrent pneumonia (HP:0006532)2.43668368
59Truncal obesity (HP:0001956)2.41894441
60Abnormal spermatogenesis (HP:0008669)2.41530123
61Mediastinal lymphadenopathy (HP:0100721)2.40542225
62Menstrual irregularities (HP:0000858)2.36868202
63Glomerulopathy (HP:0100820)2.36591575
64Increased IgE level (HP:0003212)2.35882375
65Chronic mucocutaneous candidiasis (HP:0002728)2.34053970
66Recurrent cutaneous fungal infections (HP:0011370)2.34053970
67Vasculitis (HP:0002633)2.33407886
68Gingival bleeding (HP:0000225)2.31781102
69Abnormality of the peritoneum (HP:0002585)2.31447549
70Amelogenesis imperfecta (HP:0000705)2.25177558
71Gangrene (HP:0100758)2.17325577
72Abnormality of dental color (HP:0011073)2.16929251
73Bell-shaped thorax (HP:0001591)2.13754602
74Slow saccadic eye movements (HP:0000514)2.12644507
75Acute hepatic failure (HP:0006554)2.11252510
76Portal hypertension (HP:0001409)2.09416694
77Leukocytosis (HP:0001974)2.06697291
78Facial shape deformation (HP:0011334)2.06631962
79Potter facies (HP:0002009)2.06631962
80Cellulitis (HP:0100658)2.04373822
81Spontaneous hematomas (HP:0007420)2.04360058
82Hypoplastic ischia (HP:0003175)2.04189823
83Hypoalphalipoproteinemia (HP:0003233)2.02497540
84Aplasia/Hypoplasia of the thymus (HP:0010515)2.01366701
85Hypochromic microcytic anemia (HP:0004840)1.99656328
86Osteomalacia (HP:0002749)1.99353022
87Pulmonary embolism (HP:0002204)1.98648153
88Pulmonary infiltrates (HP:0002113)1.98348651
89Anorexia (HP:0002039)1.96305829
90Urticaria (HP:0001025)1.95895254
91Azoospermia (HP:0000027)1.94397789
92Abnormal delayed hypersensitivity skin test (HP:0002963)1.92888967
93Abnormality of the hepatic vasculature (HP:0006707)1.89762201
94Abnormality of the costochondral junction (HP:0000919)1.86750795
95Abnormality of the ischium (HP:0003174)1.84536452
96Vertigo (HP:0002321)1.83094826
97Cheilitis (HP:0100825)1.81755828
98Abnormality of the endocardium (HP:0004306)1.81390302
99Prolonged bleeding time (HP:0003010)1.77545182
100Hypochromic anemia (HP:0001931)1.76187255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.92599059
2RIPK43.79108694
3TESK13.19049431
4IRAK43.11996018
5BLK3.11976653
6PIK3CG2.82843633
7INSRR2.74687604
8BRD42.64947494
9KSR22.43501893
10DDR22.39001861
11STK382.13190565
12WNK12.06182596
13MAP3K21.95933071
14MAP2K31.85115711
15PLK21.83330566
16CSK1.80192495
17IRAK11.68943441
18IRAK21.60565016
19PDK11.60395917
20TAOK31.58830182
21PDPK11.58770377
22MAP4K21.57126382
23MAP3K111.55603541
24DYRK1B1.55463399
25TYK21.50329793
26MAP3K11.43796653
27PTK2B1.41170279
28MAP4K11.39184378
29CAMK1G1.37578753
30EPHB11.36475734
31ERN11.29709202
32JAK21.28875020
33JAK31.28476537
34FES1.25502654
35TNK21.23001894
36TXK1.19488608
37GRK61.17947620
38HCK1.13575078
39ACVR1B1.12768562
40ZAP701.08280753
41IKBKE1.07621769
42STK38L1.07413920
43TESK21.05492844
44NEK61.03702092
45PNCK0.94333865
46BTK0.92222076
47SYK0.91517323
48MAP3K30.90819086
49LYN0.82705194
50RAF10.81947588
51YES10.80769952
52CDK70.76610363
53MARK20.74524793
54MAP3K140.74498390
55CDK120.73799163
56PRKG20.70396667
57FRK0.69384507
58TBK10.67766509
59OXSR10.65723799
60MAPK150.65504035
61FGR0.61557988
62DYRK30.61245965
63KIT0.60983339
64IKBKB0.58929356
65KSR10.57788575
66PRKAA20.57464562
67RPS6KA10.56791754
68CAMK1D0.56406719
69MAP3K130.55918924
70RPS6KL10.55581641
71RPS6KC10.55581641
72CAMK40.55175134
73RPS6KA60.52813984
74SIK20.52348384
75PRKCZ0.50215199
76MARK30.50175649
77TAOK10.49363215
78SGK20.47487499
79PRKG10.46416765
80MAP2K40.45816369
81BMPR20.45602714
82TEC0.45380016
83SGK30.43931202
84MAP3K80.43224205
85MAP2K20.40553133
86RPS6KA20.40255253
87MATK0.39564979
88CDK40.39076122
89FGFR30.38776598
90SGK2230.38261418
91SGK4940.38261418
92CDK190.37923540
93JAK10.37888218
94STK110.37859440
95DAPK20.37540835
96MAP3K60.37049554
97LCK0.36302763
98PRKD30.36064011
99CSF1R0.36012216
100CAMK10.35869614

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.88278402
2Leishmaniasis_Homo sapiens_hsa051402.68065391
3Osteoclast differentiation_Homo sapiens_hsa043802.56222156
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32525896
5Olfactory transduction_Homo sapiens_hsa047402.17322346
6Legionellosis_Homo sapiens_hsa051342.06407531
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.04500826
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.04075680
9B cell receptor signaling pathway_Homo sapiens_hsa046622.01264693
10Tuberculosis_Homo sapiens_hsa051521.96753586
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93752802
12Staphylococcus aureus infection_Homo sapiens_hsa051501.85651437
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84405276
14Acute myeloid leukemia_Homo sapiens_hsa052211.84055889
15Influenza A_Homo sapiens_hsa051641.83565255
16Graft-versus-host disease_Homo sapiens_hsa053321.81403059
17Allograft rejection_Homo sapiens_hsa053301.76643144
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75384879
19Dorso-ventral axis formation_Homo sapiens_hsa043201.72908085
20Autoimmune thyroid disease_Homo sapiens_hsa053201.65680694
21Measles_Homo sapiens_hsa051621.65322357
22Antigen processing and presentation_Homo sapiens_hsa046121.56321799
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55007795
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.54099515
25Type I diabetes mellitus_Homo sapiens_hsa049401.50113455
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48407853
27Chemokine signaling pathway_Homo sapiens_hsa040621.41744176
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.41567120
29Malaria_Homo sapiens_hsa051441.40922954
30Type II diabetes mellitus_Homo sapiens_hsa049301.33619484
31Toxoplasmosis_Homo sapiens_hsa051451.32119436
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28979235
33Non-small cell lung cancer_Homo sapiens_hsa052231.27684312
34VEGF signaling pathway_Homo sapiens_hsa043701.20935413
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19737978
36Endocytosis_Homo sapiens_hsa041441.18798366
37Inositol phosphate metabolism_Homo sapiens_hsa005621.18272533
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.17459911
39Hepatitis B_Homo sapiens_hsa051611.16272590
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.15893619
41Viral myocarditis_Homo sapiens_hsa054161.13946345
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12830187
43T cell receptor signaling pathway_Homo sapiens_hsa046601.11162277
44Herpes simplex infection_Homo sapiens_hsa051681.06874954
45Phagosome_Homo sapiens_hsa041451.05572719
46TNF signaling pathway_Homo sapiens_hsa046681.02907347
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02437451
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98671177
49Prolactin signaling pathway_Homo sapiens_hsa049170.97684437
50Hematopoietic cell lineage_Homo sapiens_hsa046400.89367094
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84294199
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84285435
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82521501
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82226145
55African trypanosomiasis_Homo sapiens_hsa051430.79518954
56FoxO signaling pathway_Homo sapiens_hsa040680.73343402
57Pancreatic cancer_Homo sapiens_hsa052120.72627621
58Viral carcinogenesis_Homo sapiens_hsa052030.72302732
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71633287
60HIF-1 signaling pathway_Homo sapiens_hsa040660.70747668
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70722230
62Platelet activation_Homo sapiens_hsa046110.69778708
63Regulation of autophagy_Homo sapiens_hsa041400.68745608
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67700565
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.67409611
66Renal cell carcinoma_Homo sapiens_hsa052110.67303457
67Estrogen signaling pathway_Homo sapiens_hsa049150.66099588
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65407164
69MAPK signaling pathway_Homo sapiens_hsa040100.64735698
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.64505668
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63199762
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63037533
73Pertussis_Homo sapiens_hsa051330.62935755
74Apoptosis_Homo sapiens_hsa042100.62529998
75mTOR signaling pathway_Homo sapiens_hsa041500.61617010
76cAMP signaling pathway_Homo sapiens_hsa040240.60850504
77Hepatitis C_Homo sapiens_hsa051600.59443395
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58181788
79Endometrial cancer_Homo sapiens_hsa052130.56841033
80Chronic myeloid leukemia_Homo sapiens_hsa052200.56813085
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.55544190
82Choline metabolism in cancer_Homo sapiens_hsa052310.55075289
83Taste transduction_Homo sapiens_hsa047420.52706192
84Prostate cancer_Homo sapiens_hsa052150.52622320
85Epstein-Barr virus infection_Homo sapiens_hsa051690.50132653
86ErbB signaling pathway_Homo sapiens_hsa040120.50129731
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49716519
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47866450
89Primary immunodeficiency_Homo sapiens_hsa053400.47371996
90Insulin resistance_Homo sapiens_hsa049310.47202651
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.45155305
92Salmonella infection_Homo sapiens_hsa051320.41841775
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40375168
94Shigellosis_Homo sapiens_hsa051310.37147299
95Phenylalanine metabolism_Homo sapiens_hsa003600.35525972
96Long-term potentiation_Homo sapiens_hsa047200.34088270
97Notch signaling pathway_Homo sapiens_hsa043300.33529035
98Amoebiasis_Homo sapiens_hsa051460.32414212
99Glioma_Homo sapiens_hsa052140.32224107
100Morphine addiction_Homo sapiens_hsa050320.32031152

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