SUMO1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.50769701
2proteasome assembly (GO:0043248)4.88750280
3cytidine metabolic process (GO:0046087)4.26582920
4cytidine catabolic process (GO:0006216)4.26582920
5cytidine deamination (GO:0009972)4.26582920
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.20258913
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.16909354
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02945075
9ATP synthesis coupled proton transport (GO:0015986)4.02945075
10RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.97910559
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93703872
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79260528
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76766198
14signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.74463408
15signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.74463408
16signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.74463408
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.71617892
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.71617892
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70976710
20regulation of cellular amino acid metabolic process (GO:0006521)3.70462205
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.69688576
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68617801
23signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68617801
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67199126
25respiratory electron transport chain (GO:0022904)3.56646400
26pyrimidine ribonucleoside catabolic process (GO:0046133)3.55673906
27signal transduction involved in cell cycle checkpoint (GO:0072395)3.55304975
28signal transduction involved in DNA integrity checkpoint (GO:0072401)3.55057319
29signal transduction involved in DNA damage checkpoint (GO:0072422)3.55057319
30electron transport chain (GO:0022900)3.51824482
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47317830
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.42886085
33negative regulation of ligase activity (GO:0051352)3.39470641
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39470641
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.38438232
36platelet dense granule organization (GO:0060155)3.34657517
37antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.32309436
38protein neddylation (GO:0045116)3.29241762
39deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.28061235
40negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.19522103
41B cell mediated immunity (GO:0019724)3.18227762
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15712896
43positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15632987
44purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.15230652
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09524983
46histone mRNA metabolic process (GO:0008334)3.07360875
47purine deoxyribonucleotide catabolic process (GO:0009155)3.05883560
48positive regulation of ligase activity (GO:0051351)3.04901058
49protein complex biogenesis (GO:0070271)3.00294944
50cullin deneddylation (GO:0010388)2.99119449
51respiratory chain complex IV assembly (GO:0008535)2.98356119
52antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.97040961
53mitochondrial respiratory chain complex assembly (GO:0033108)2.96340046
54organelle disassembly (GO:1903008)2.93207029
55positive regulation of cell cycle arrest (GO:0071158)2.89739711
56immunoglobulin mediated immune response (GO:0016064)2.89630199
57actin nucleation (GO:0045010)2.87263166
58regulation of germinal center formation (GO:0002634)2.87197490
59CENP-A containing nucleosome assembly (GO:0034080)2.83328678
60DNA demethylation (GO:0080111)2.81780333
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.81138515
62NADH dehydrogenase complex assembly (GO:0010257)2.81138515
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81138515
64DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.77367842
65DNA catabolic process, exonucleolytic (GO:0000738)2.76950506
66synapsis (GO:0007129)2.76596350
67negative regulation of heart rate (GO:0010459)2.75867262
68protein deneddylation (GO:0000338)2.75723264
69response to pheromone (GO:0019236)2.75057058
70regulation of mitotic spindle checkpoint (GO:1903504)2.74660157
71regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74660157
72chromatin remodeling at centromere (GO:0031055)2.74641803
73DNA replication-dependent nucleosome assembly (GO:0006335)2.73577868
74DNA replication-dependent nucleosome organization (GO:0034723)2.73577868
75maturation of 5.8S rRNA (GO:0000460)2.72286023
76response to interferon-beta (GO:0035456)2.72261716
77regulation of interleukin-8 secretion (GO:2000482)2.70770569
78DNA double-strand break processing (GO:0000729)2.69062744
79cytochrome complex assembly (GO:0017004)2.67938467
80regulation of cellular amine metabolic process (GO:0033238)2.67331252
81positive regulation of interleukin-1 beta secretion (GO:0050718)2.66654267
82mismatch repair (GO:0006298)2.65983556
83positive regulation of interleukin-8 secretion (GO:2000484)2.65777968
84protein-cofactor linkage (GO:0018065)2.62901916
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62840107
86regulation of ubiquitin-protein transferase activity (GO:0051438)2.62657517
87rRNA modification (GO:0000154)2.62495871
88mast cell activation (GO:0045576)2.62403957
89iron-sulfur cluster assembly (GO:0016226)2.61663118
90metallo-sulfur cluster assembly (GO:0031163)2.61663118
91spliceosomal complex assembly (GO:0000245)2.61386770
92GPI anchor metabolic process (GO:0006505)2.60962806
93rRNA catabolic process (GO:0016075)2.60544613
94oxidative phosphorylation (GO:0006119)2.59497594
95adenosine metabolic process (GO:0046085)2.58849447
96purine deoxyribonucleotide metabolic process (GO:0009151)2.58703720
97GPI anchor biosynthetic process (GO:0006506)2.57690850
98DNA dealkylation (GO:0035510)2.56872329
99regulation of ligase activity (GO:0051340)2.56005852
100signal peptide processing (GO:0006465)2.55142546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.94902954
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.84840798
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.38817664
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.30257054
5ELK1_19687146_ChIP-ChIP_HELA_Human2.79171614
6IGF1R_20145208_ChIP-Seq_DFB_Human2.76585117
7VDR_22108803_ChIP-Seq_LS180_Human2.72110799
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.70292308
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67920824
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58904258
11VDR_23849224_ChIP-Seq_CD4+_Human2.57380907
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54578893
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49042041
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48493630
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.47022886
16ZNF274_21170338_ChIP-Seq_K562_Hela2.43018943
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32793906
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22587280
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20516968
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12705285
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12072156
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06951117
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.97429824
24FOXP3_21729870_ChIP-Seq_TREG_Human1.96833420
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95690504
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.90218395
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89485093
28EWS_26573619_Chip-Seq_HEK293_Human1.86213317
29TAF15_26573619_Chip-Seq_HEK293_Human1.86182944
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83554975
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80049712
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63838211
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58991999
34FUS_26573619_Chip-Seq_HEK293_Human1.57654119
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56962277
36P300_19829295_ChIP-Seq_ESCs_Human1.54754927
37MYC_18940864_ChIP-ChIP_HL60_Human1.52069760
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50713972
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.50226552
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47188648
41ER_23166858_ChIP-Seq_MCF-7_Human1.43976628
42GATA3_26560356_Chip-Seq_TH2_Human1.42444793
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38168239
44TP53_22573176_ChIP-Seq_HFKS_Human1.36972098
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36951631
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36299531
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34697574
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34215280
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.33385481
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33331458
51AR_20517297_ChIP-Seq_VCAP_Human1.31026708
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.30752602
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30752602
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29985973
55CBP_20019798_ChIP-Seq_JUKART_Human1.29985973
56SOX2_19829295_ChIP-Seq_ESCs_Human1.28297331
57NANOG_19829295_ChIP-Seq_ESCs_Human1.28297331
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26127646
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24405612
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24365541
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24129738
62MYB_26560356_Chip-Seq_TH2_Human1.23818671
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.23656940
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22942869
65BCAT_22108803_ChIP-Seq_LS180_Human1.22090799
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16976410
67GBX2_23144817_ChIP-Seq_PC3_Human1.14618881
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13812849
69TCF4_22108803_ChIP-Seq_LS180_Human1.11932513
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.11556949
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11365784
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09553903
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09175154
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08956962
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.06457503
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05432968
77MYC_18555785_ChIP-Seq_MESCs_Mouse1.05165203
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04483640
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04296415
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04006986
81DCP1A_22483619_ChIP-Seq_HELA_Human0.99623870
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99606527
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99267043
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.99032521
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.98989461
86SPI1_23547873_ChIP-Seq_NB4_Human0.98762401
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98687587
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.98461047
89SALL4_22934838_ChIP-ChIP_CD34+_Human0.97969866
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94559212
91GATA3_27048872_Chip-Seq_THYMUS_Human0.93669484
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93615109
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.93467884
94NCOR_22424771_ChIP-Seq_293T_Human0.93327952
95GATA3_26560356_Chip-Seq_TH1_Human0.93126523
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92473572
97P53_22387025_ChIP-Seq_ESCs_Mouse0.92461929
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.92229440
99CDX2_22108803_ChIP-Seq_LS180_Human0.89063311
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88876106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.14544110
2MP0005671_abnormal_response_to3.85548839
3MP0001835_abnormal_antigen_presentation3.62918513
4MP0006072_abnormal_retinal_apoptosis2.92440330
5MP0002166_altered_tumor_susceptibility2.79362364
6MP0005075_abnormal_melanosome_morpholog2.59552124
7MP0002006_tumorigenesis2.34520094
8MP0000372_irregular_coat_pigmentation2.30170353
9MP0005084_abnormal_gallbladder_morpholo2.18997120
10MP0008877_abnormal_DNA_methylation2.14393866
11MP0003880_abnormal_central_pattern2.11218656
12MP0000516_abnormal_urinary_system2.09173381
13MP0005367_renal/urinary_system_phenotyp2.09173381
14MP0002102_abnormal_ear_morphology2.07981458
15MP0003195_calcinosis2.04887079
16MP0009785_altered_susceptibility_to2.00732677
17MP0008872_abnormal_physiological_respon1.82299850
18MP0002837_dystrophic_cardiac_calcinosis1.82067874
19MP0001800_abnormal_humoral_immune1.77945730
20MP0008058_abnormal_DNA_repair1.76944377
21MP0002148_abnormal_hypersensitivity_rea1.71021307
22MP0005000_abnormal_immune_tolerance1.70343700
23MP0008875_abnormal_xenobiotic_pharmacok1.70045190
24MP0003786_premature_aging1.65842530
25MP0001529_abnormal_vocalization1.65653003
26MP0006036_abnormal_mitochondrial_physio1.62057752
27MP0002736_abnormal_nociception_after1.60521078
28MP0009764_decreased_sensitivity_to1.59156804
29MP0004147_increased_porphyrin_level1.56161895
30MP0001968_abnormal_touch/_nociception1.53767647
31MP0010094_abnormal_chromosome_stability1.49124678
32MP0003252_abnormal_bile_duct1.48869314
33MP0005253_abnormal_eye_physiology1.44266358
34MP0002138_abnormal_hepatobiliary_system1.44149077
35MP0002723_abnormal_immune_serum1.43874589
36MP0009697_abnormal_copulation1.39974070
37MP0005551_abnormal_eye_electrophysiolog1.39472888
38MP0001984_abnormal_olfaction1.39262687
39MP0006054_spinal_hemorrhage1.37163269
40MP0002452_abnormal_antigen_presenting1.37155510
41MP0000685_abnormal_immune_system1.32296406
42MP0002420_abnormal_adaptive_immunity1.31633809
43MP0001819_abnormal_immune_cell1.30069577
44MP0005645_abnormal_hypothalamus_physiol1.28915251
45MP0003646_muscle_fatigue1.26121582
46MP0005646_abnormal_pituitary_gland1.25319541
47MP0002751_abnormal_autonomic_nervous1.24943191
48MP0006082_CNS_inflammation1.22543147
49MP0004145_abnormal_muscle_electrophysio1.19605429
50MP0001919_abnormal_reproductive_system1.18193840
51MP0003763_abnormal_thymus_physiology1.17842501
52MP0001790_abnormal_immune_system1.17723963
53MP0005387_immune_system_phenotype1.17723963
54MP0008007_abnormal_cellular_replicative1.14890452
55MP0003567_abnormal_fetal_cardiomyocyte1.06430345
56MP0003137_abnormal_impulse_conducting1.04212375
57MP0000716_abnormal_immune_system1.01408145
58MP0010155_abnormal_intestine_physiology1.01142513
59MP0005025_abnormal_response_to1.00747411
60MP0002398_abnormal_bone_marrow1.00271607
61MP0003724_increased_susceptibility_to1.00111654
62MP0006035_abnormal_mitochondrial_morpho0.99509662
63MP0003718_maternal_effect0.98798507
64MP0000569_abnormal_digit_pigmentation0.98746953
65MP0005389_reproductive_system_phenotype0.98296824
66MP0002234_abnormal_pharynx_morphology0.97652525
67MP0004957_abnormal_blastocyst_morpholog0.97069370
68MP0004142_abnormal_muscle_tone0.96728855
69MP0005408_hypopigmentation0.96544914
70MP0003693_abnormal_embryo_hatching0.96380596
71MP0001905_abnormal_dopamine_level0.95395051
72MP0001845_abnormal_inflammatory_respons0.95028552
73MP0004215_abnormal_myocardial_fiber0.94776166
74MP0009333_abnormal_splenocyte_physiolog0.93771030
75MP0008873_increased_physiological_sensi0.89334653
76MP0005410_abnormal_fertilization0.89101072
77MP0000689_abnormal_spleen_morphology0.89014305
78MP0001764_abnormal_homeostasis0.88956454
79MP0006276_abnormal_autonomic_nervous0.87879830
80MP0005174_abnormal_tail_pigmentation0.83422695
81MP0002282_abnormal_trachea_morphology0.83176426
82MP0002019_abnormal_tumor_incidence0.82936884
83MP0003866_abnormal_defecation0.82815199
84MP0008995_early_reproductive_senescence0.81698172
85MP0005332_abnormal_amino_acid0.80161984
86MP0003186_abnormal_redox_activity0.79664982
87MP0005085_abnormal_gallbladder_physiolo0.78632801
88MP0002419_abnormal_innate_immunity0.77842838
89MP0005636_abnormal_mineral_homeostasis0.77762579
90MP0002876_abnormal_thyroid_physiology0.74800430
91MP0001485_abnormal_pinna_reflex0.74452866
92MP0001501_abnormal_sleep_pattern0.74198823
93MP0002429_abnormal_blood_cell0.73579233
94MP0009046_muscle_twitch0.73271770
95MP0001986_abnormal_taste_sensitivity0.73243246
96MP0003011_delayed_dark_adaptation0.70949331
97MP0006292_abnormal_olfactory_placode0.70819455
98MP0001929_abnormal_gametogenesis0.69137567
99MP0008469_abnormal_protein_level0.68293565
100MP0002405_respiratory_system_inflammati0.66298385

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)4.33931504
2Acute necrotizing encephalopathy (HP:0006965)3.95146780
3Mitochondrial inheritance (HP:0001427)3.93342724
4Increased CSF lactate (HP:0002490)3.63010639
5Hepatocellular necrosis (HP:0001404)3.56500347
6Acute encephalopathy (HP:0006846)3.55326540
7Progressive macrocephaly (HP:0004481)3.47434491
8Abnormal mitochondria in muscle tissue (HP:0008316)3.42996219
9Abolished electroretinogram (ERG) (HP:0000550)3.25465020
10Hepatic necrosis (HP:0002605)3.25180870
11Abnormality of the prostate (HP:0008775)3.19392725
12Pancreatic cysts (HP:0001737)3.11294525
13Elevated erythrocyte sedimentation rate (HP:0003565)3.04307731
143-Methylglutaconic aciduria (HP:0003535)3.03869364
15IgG deficiency (HP:0004315)3.00874511
16Increased hepatocellular lipid droplets (HP:0006565)2.92509538
17Hypoproteinemia (HP:0003075)2.88441248
18Lipid accumulation in hepatocytes (HP:0006561)2.68571805
19Severe combined immunodeficiency (HP:0004430)2.67654772
20Cerebral edema (HP:0002181)2.61500338
21Congenital stationary night blindness (HP:0007642)2.61370732
22Abnormality of B cell number (HP:0010975)2.60267732
23Lactic acidosis (HP:0003128)2.55408872
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44787009
25Exertional dyspnea (HP:0002875)2.44223074
26Methylmalonic acidemia (HP:0002912)2.43805184
27Abnormality of midbrain morphology (HP:0002418)2.43540331
28Molar tooth sign on MRI (HP:0002419)2.43540331
29Increased serum lactate (HP:0002151)2.43102425
30Optic disc pallor (HP:0000543)2.38947472
31Thyroiditis (HP:0100646)2.38084529
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35891056
33Abnormality of alanine metabolism (HP:0010916)2.35891056
34Hyperalaninemia (HP:0003348)2.35891056
35B lymphocytopenia (HP:0010976)2.33981920
36Attenuation of retinal blood vessels (HP:0007843)2.33631060
37Decreased central vision (HP:0007663)2.33517915
38Renal Fanconi syndrome (HP:0001994)2.30382812
39Type I transferrin isoform profile (HP:0003642)2.30047045
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28099669
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28099669
42Abnormal rod and cone electroretinograms (HP:0008323)2.26143729
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26116097
44Hypothermia (HP:0002045)2.22411100
45Pancreatic fibrosis (HP:0100732)2.21926353
46Eosinophilia (HP:0001880)2.17887355
47Aplastic anemia (HP:0001915)2.13789184
48Abnormality of eosinophils (HP:0001879)2.11612498
49True hermaphroditism (HP:0010459)2.07800605
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.07612417
51Increased IgM level (HP:0003496)2.05423616
52Combined immunodeficiency (HP:0005387)2.05328787
53Autoimmune hemolytic anemia (HP:0001890)2.05307983
54Increased intramyocellular lipid droplets (HP:0012240)2.04850304
55Leukodystrophy (HP:0002415)2.03752994
56Abnormality of T cell number (HP:0011839)2.02961531
57Abnormality of the axillary hair (HP:0100134)2.01727216
58Abnormality of secondary sexual hair (HP:0009888)2.01727216
59Colon cancer (HP:0003003)1.98918603
60Respiratory failure (HP:0002878)1.97313091
61Meckel diverticulum (HP:0002245)1.95787052
62Progressive microcephaly (HP:0000253)1.95537995
63Abnormality of the ileum (HP:0001549)1.91611506
64Stomatitis (HP:0010280)1.89438559
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88077680
66Abnormality of serum amino acid levels (HP:0003112)1.87867263
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85888122
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85449191
69Aplasia/hypoplasia of the uterus (HP:0008684)1.85443807
70Nephronophthisis (HP:0000090)1.84937091
71T lymphocytopenia (HP:0005403)1.82670036
72Increased corneal curvature (HP:0100692)1.82007035
73Keratoconus (HP:0000563)1.82007035
74Agnosia (HP:0010524)1.81738021
75Lethargy (HP:0001254)1.81016794
76Dry hair (HP:0011359)1.80321142
77Abnormality of male internal genitalia (HP:0000022)1.78200185
78Abnormality of T cells (HP:0002843)1.78011268
79Medial flaring of the eyebrow (HP:0010747)1.77252736
80Methylmalonic aciduria (HP:0012120)1.77234190
81Alveolar cell carcinoma (HP:0006519)1.76299154
82Abnormal protein glycosylation (HP:0012346)1.75600538
83Abnormal glycosylation (HP:0012345)1.75600538
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75600538
85Abnormal protein N-linked glycosylation (HP:0012347)1.75600538
86Polydipsia (HP:0001959)1.75513760
87Abnormal drinking behavior (HP:0030082)1.75513760
88Bile duct proliferation (HP:0001408)1.71527108
89Abnormal biliary tract physiology (HP:0012439)1.71527108
90Palpitations (HP:0001962)1.70825400
91Type II lissencephaly (HP:0007260)1.70748318
92Atrophy/Degeneration involving motor neurons (HP:0007373)1.70100745
93Granulocytopenia (HP:0001913)1.68839264
94Degeneration of anterior horn cells (HP:0002398)1.68367738
95Abnormality of the anterior horn cell (HP:0006802)1.68367738
96Abnormality of the pleura (HP:0002103)1.68204226
97Clubbing of toes (HP:0100760)1.67420698
98Chronic diarrhea (HP:0002028)1.67261241
99CNS demyelination (HP:0007305)1.66869395
100Hyperglycinuria (HP:0003108)1.65731276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.04894050
2ZAK3.29021823
3FRK2.78176173
4MAP3K122.64560788
5TLK12.53662550
6KDR2.49036018
7TAOK32.38446114
8BMPR22.21261746
9MST42.18911141
10SRPK12.01816797
11TRIM282.00372130
12ERBB31.98223277
13MAP4K21.97199232
14EIF2AK11.94584169
15MKNK21.93589507
16NUAK11.90215952
17VRK11.88949019
18ADRBK21.80939949
19TXK1.79881791
20VRK21.76769001
21ACVR1B1.71738743
22WNK31.63660116
23GRK11.58550582
24MKNK11.53785490
25PLK41.51704749
26BMPR1B1.49249253
27OXSR11.46491789
28TEC1.46319631
29BCKDK1.45195860
30PLK31.32076841
31INSRR1.28012843
32KIT1.27413734
33MYLK1.25808806
34BUB11.24852460
35BCR1.17485178
36PINK11.11952697
37TSSK61.09785710
38PLK21.08547810
39ITK1.08425037
40EIF2AK21.05002119
41STK391.00343505
42CDK190.98663152
43MAP4K10.91446238
44SCYL20.90654101
45SYK0.89938586
46TNIK0.87196847
47DAPK10.86330732
48STK160.83268240
49IKBKB0.81353911
50CSNK1G30.80196495
51CSNK1G10.76048976
52PIK3CG0.75763804
53RPS6KA50.75073930
54STK38L0.74045009
55WEE10.73601146
56WNK40.73372948
57TESK20.72811766
58LYN0.72352108
59CDC70.71367560
60CSF1R0.71365295
61MAPK130.70419968
62PDK20.70338375
63CSNK1G20.70042826
64MAP3K140.63496618
65LIMK10.61907830
66IGF1R0.59867837
67ATR0.58534690
68GRK60.57795453
69FES0.55978734
70PRKCE0.55106823
71ADRBK10.54625578
72IKBKE0.54225442
73BTK0.53938103
74PLK10.53705179
75LCK0.53320998
76GRK70.53307666
77CSNK1A1L0.53183760
78TIE10.53093967
79MAPKAPK30.52997360
80FLT30.52500580
81TTK0.52209277
82PRKCQ0.50305912
83RPS6KA40.49055386
84MAP3K40.46865349
85TRPM70.45529866
86PHKG10.42630887
87PHKG20.42630887
88ABL10.42246285
89CSNK2A10.40527328
90TNK20.40499992
91ROCK10.38584774
92DAPK30.37156551
93AURKB0.36986935
94PBK0.36783888
95EGFR0.36583716
96PASK0.35846547
97CSNK1A10.35604633
98MAPKAPK50.35116735
99NEK10.34715363
100PNCK0.34160885

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.43449817
2Asthma_Homo sapiens_hsa053103.86725335
3Protein export_Homo sapiens_hsa030603.53420014
4Allograft rejection_Homo sapiens_hsa053303.22312659
5Graft-versus-host disease_Homo sapiens_hsa053323.21375694
6Autoimmune thyroid disease_Homo sapiens_hsa053203.14258204
7Oxidative phosphorylation_Homo sapiens_hsa001903.04555942
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.89222228
9Type I diabetes mellitus_Homo sapiens_hsa049402.61534189
10Parkinsons disease_Homo sapiens_hsa050122.48345391
11Antigen processing and presentation_Homo sapiens_hsa046122.30091154
12Primary immunodeficiency_Homo sapiens_hsa053401.95475217
13Homologous recombination_Homo sapiens_hsa034401.85988035
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74739418
15Rheumatoid arthritis_Homo sapiens_hsa053231.74276534
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67031137
17Alzheimers disease_Homo sapiens_hsa050101.64679689
18Mismatch repair_Homo sapiens_hsa034301.61430470
19Phototransduction_Homo sapiens_hsa047441.58236251
20Viral myocarditis_Homo sapiens_hsa054161.56924578
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55686069
22RNA degradation_Homo sapiens_hsa030181.55384690
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54298048
24Huntingtons disease_Homo sapiens_hsa050161.53231849
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47770525
26Fanconi anemia pathway_Homo sapiens_hsa034601.45061290
27RNA polymerase_Homo sapiens_hsa030201.44495568
28Non-homologous end-joining_Homo sapiens_hsa034501.43215984
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39403066
30Systemic lupus erythematosus_Homo sapiens_hsa053221.36522683
31Ribosome_Homo sapiens_hsa030101.34061657
32Propanoate metabolism_Homo sapiens_hsa006401.31944094
33DNA replication_Homo sapiens_hsa030301.25184015
34Staphylococcus aureus infection_Homo sapiens_hsa051501.15073219
35Hematopoietic cell lineage_Homo sapiens_hsa046401.14895718
36Nucleotide excision repair_Homo sapiens_hsa034201.13668374
37Spliceosome_Homo sapiens_hsa030401.11962130
38Basal transcription factors_Homo sapiens_hsa030221.03134455
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02647493
40RNA transport_Homo sapiens_hsa030131.01700220
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97343161
42Nitrogen metabolism_Homo sapiens_hsa009100.92480686
43Cardiac muscle contraction_Homo sapiens_hsa042600.92069272
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86690501
45Caffeine metabolism_Homo sapiens_hsa002320.83657755
46Leishmaniasis_Homo sapiens_hsa051400.82548370
47Linoleic acid metabolism_Homo sapiens_hsa005910.81714131
48Tryptophan metabolism_Homo sapiens_hsa003800.80141180
49Base excision repair_Homo sapiens_hsa034100.79528530
50Sulfur metabolism_Homo sapiens_hsa009200.78719100
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78318129
52Collecting duct acid secretion_Homo sapiens_hsa049660.75679136
53One carbon pool by folate_Homo sapiens_hsa006700.73433413
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71770559
55Purine metabolism_Homo sapiens_hsa002300.68736146
56Herpes simplex infection_Homo sapiens_hsa051680.68370975
57Peroxisome_Homo sapiens_hsa041460.65117908
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64747345
59Regulation of autophagy_Homo sapiens_hsa041400.63060532
60Pyruvate metabolism_Homo sapiens_hsa006200.62938366
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61840078
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61619984
63Pyrimidine metabolism_Homo sapiens_hsa002400.60833209
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59628861
65Legionellosis_Homo sapiens_hsa051340.57614027
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57207355
67Butanoate metabolism_Homo sapiens_hsa006500.55516708
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55010164
69Ether lipid metabolism_Homo sapiens_hsa005650.50588470
70Chemical carcinogenesis_Homo sapiens_hsa052040.47841898
71Olfactory transduction_Homo sapiens_hsa047400.45644444
72Epstein-Barr virus infection_Homo sapiens_hsa051690.43796982
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43776764
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.43490599
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41268409
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.41107604
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39201969
78p53 signaling pathway_Homo sapiens_hsa041150.38277114
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37786726
80Arachidonic acid metabolism_Homo sapiens_hsa005900.37535666
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37500429
82Metabolic pathways_Homo sapiens_hsa011000.36406312
83Shigellosis_Homo sapiens_hsa051310.33837172
84Tuberculosis_Homo sapiens_hsa051520.32227375
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.32192685
86Measles_Homo sapiens_hsa051620.31930225
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31295197
88Retinol metabolism_Homo sapiens_hsa008300.31056046
89Toxoplasmosis_Homo sapiens_hsa051450.30020078
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30002546
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.27088614
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26316721
93Fatty acid elongation_Homo sapiens_hsa000620.25239626
94Salmonella infection_Homo sapiens_hsa051320.22245484
95Phagosome_Homo sapiens_hsa041450.21755960
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.21197313
97beta-Alanine metabolism_Homo sapiens_hsa004100.21167375
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.21115806
99Steroid biosynthesis_Homo sapiens_hsa001000.20860742
100Alcoholism_Homo sapiens_hsa050340.20795652

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »