SUMO1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.78769975
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.36322070
3ATP synthesis coupled proton transport (GO:0015986)5.85072735
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.85072735
5respiratory electron transport chain (GO:0022904)5.52163152
6electron transport chain (GO:0022900)5.39493763
7protein complex biogenesis (GO:0070271)4.75415551
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.73528394
9mitochondrial respiratory chain complex I assembly (GO:0032981)4.73528394
10NADH dehydrogenase complex assembly (GO:0010257)4.73528394
11protein-cofactor linkage (GO:0018065)4.67144805
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.53255675
13mitochondrial respiratory chain complex assembly (GO:0033108)4.30555973
14DNA deamination (GO:0045006)4.19661084
15termination of RNA polymerase III transcription (GO:0006386)4.18800802
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.18800802
17positive regulation of prostaglandin secretion (GO:0032308)4.08827332
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87945102
19chaperone-mediated protein transport (GO:0072321)3.80612454
20cotranslational protein targeting to membrane (GO:0006613)3.79831112
21cytidine deamination (GO:0009972)3.77782019
22cytidine metabolic process (GO:0046087)3.77782019
23cytidine catabolic process (GO:0006216)3.77782019
24protein targeting to ER (GO:0045047)3.74969420
25protein localization to cilium (GO:0061512)3.72573404
26ribosomal large subunit biogenesis (GO:0042273)3.69308078
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.67821555
28protein localization to endoplasmic reticulum (GO:0070972)3.63424244
29regulation of prostaglandin secretion (GO:0032306)3.61597191
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.61125580
31viral transcription (GO:0019083)3.58811956
32hydrogen ion transmembrane transport (GO:1902600)3.53854262
33translational termination (GO:0006415)3.41696311
34platelet dense granule organization (GO:0060155)3.40819033
35regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.39557920
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35948787
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35763032
38proton transport (GO:0015992)3.26386977
39hydrogen transport (GO:0006818)3.22011866
40anterograde synaptic vesicle transport (GO:0048490)3.19672471
41regulation of cellular respiration (GO:0043457)3.14915418
42interleukin-1-mediated signaling pathway (GO:0070498)3.12976091
43pyrimidine ribonucleoside catabolic process (GO:0046133)3.12561054
44tryptophan metabolic process (GO:0006568)3.03567096
45detection of light stimulus involved in visual perception (GO:0050908)3.03054920
46detection of light stimulus involved in sensory perception (GO:0050962)3.03054920
47indolalkylamine metabolic process (GO:0006586)3.00178258
48oxidative phosphorylation (GO:0006119)2.96951557
49positive regulation of transcription regulatory region DNA binding (GO:2000679)2.95877097
50positive regulation of osteoclast differentiation (GO:0045672)2.95723650
51regulation of oxidative phosphorylation (GO:0002082)2.94968467
52inner mitochondrial membrane organization (GO:0007007)2.94621108
53antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.91518865
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89477407
55purine-containing compound salvage (GO:0043101)2.89108296
56translational elongation (GO:0006414)2.88130887
57viral protein processing (GO:0019082)2.86643780
58mast cell activation (GO:0045576)2.84851334
59kynurenine metabolic process (GO:0070189)2.84706084
60signal peptide processing (GO:0006465)2.84435305
61positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83993486
62regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.81439986
63protein neddylation (GO:0045116)2.79659465
64ATP biosynthetic process (GO:0006754)2.78199108
65spliceosomal complex assembly (GO:0000245)2.77484001
66one-carbon compound transport (GO:0019755)2.76686664
67proteasome assembly (GO:0043248)2.74737918
68tryptophan catabolic process (GO:0006569)2.74666991
69indole-containing compound catabolic process (GO:0042436)2.74666991
70indolalkylamine catabolic process (GO:0046218)2.74666991
71mismatch repair (GO:0006298)2.73233034
72antigen processing and presentation via MHC class Ib (GO:0002475)2.69017575
73translation (GO:0006412)2.66429475
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65349864
75translational initiation (GO:0006413)2.65208773
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65135667
77L-fucose catabolic process (GO:0042355)2.64079062
78fucose catabolic process (GO:0019317)2.64079062
79L-fucose metabolic process (GO:0042354)2.64079062
80antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.63352393
81positive regulation of interleukin-8 secretion (GO:2000484)2.62201947
82positive regulation of response to biotic stimulus (GO:0002833)2.61434374
83regulation of interleukin-8 secretion (GO:2000482)2.61169008
84prenylation (GO:0097354)2.60054465
85protein prenylation (GO:0018342)2.60054465
86positive regulation of icosanoid secretion (GO:0032305)2.58521626
87immunoglobulin mediated immune response (GO:0016064)2.58499941
88purinergic nucleotide receptor signaling pathway (GO:0035590)2.58022909
89positive regulation of interleukin-1 beta secretion (GO:0050718)2.57807567
90negative regulation of B cell proliferation (GO:0030889)2.57144568
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56714661
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56714661
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56714661
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55265882
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55265882
96regulation of interleukin-6 biosynthetic process (GO:0045408)2.54807039
97Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53943648
98transcription elongation from RNA polymerase I promoter (GO:0006362)2.51669161
99positive regulation of mast cell activation (GO:0033005)2.51360492
100regulation of cellular amino acid metabolic process (GO:0006521)2.50928768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.36654728
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.98948390
3FLI1_27457419_Chip-Seq_LIVER_Mouse3.18767452
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.04704323
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.04264756
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00283730
7VDR_22108803_ChIP-Seq_LS180_Human2.72117045
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67751981
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.47490214
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28760798
11VDR_23849224_ChIP-Seq_CD4+_Human2.28461963
12ELK1_19687146_ChIP-ChIP_HELA_Human2.24282913
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21421767
14TAF15_26573619_Chip-Seq_HEK293_Human2.11650392
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06859827
16IGF1R_20145208_ChIP-Seq_DFB_Human2.03581708
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.02384014
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99075670
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98686784
20ZNF274_21170338_ChIP-Seq_K562_Hela1.98172940
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.90019103
22EWS_26573619_Chip-Seq_HEK293_Human1.89931055
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85477145
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84770349
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.82216275
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78900980
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65705928
28FUS_26573619_Chip-Seq_HEK293_Human1.61970555
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.61166473
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56646681
31P300_19829295_ChIP-Seq_ESCs_Human1.55963865
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54492976
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54395150
34FOXP3_21729870_ChIP-Seq_TREG_Human1.53339056
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.49933731
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49933731
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48376979
38ER_23166858_ChIP-Seq_MCF-7_Human1.48286605
39MYC_18940864_ChIP-ChIP_HL60_Human1.47223654
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46771371
41TP53_22573176_ChIP-Seq_HFKS_Human1.40525234
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38508731
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37900906
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35513295
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.33499478
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33443840
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33101435
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.32294371
49NANOG_19829295_ChIP-Seq_ESCs_Human1.32147957
50SOX2_19829295_ChIP-Seq_ESCs_Human1.32147957
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31940605
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.30184049
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30031454
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.27568817
55GATA3_26560356_Chip-Seq_TH2_Human1.27387945
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26616916
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25594545
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25507448
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25171313
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24704628
61OCT4_18555785_Chip-Seq_ESCs_Mouse1.23347892
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22977620
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22761369
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.22154282
65HTT_18923047_ChIP-ChIP_STHdh_Human1.21794134
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.21784258
67GBX2_23144817_ChIP-Seq_PC3_Human1.21532756
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21395123
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21055566
70SPI1_23547873_ChIP-Seq_NB4_Human1.20147547
71P53_22387025_ChIP-Seq_ESCs_Mouse1.19471502
72P300_18555785_Chip-Seq_ESCs_Mouse1.18208091
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17481489
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.17461769
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.16141654
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.15377706
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.14963729
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14468041
79CBP_20019798_ChIP-Seq_JUKART_Human1.14468041
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.13648717
81TCF4_22108803_ChIP-Seq_LS180_Human1.13186370
82SOX2_18555785_Chip-Seq_ESCs_Mouse1.12332260
83IRF1_19129219_ChIP-ChIP_H3396_Human1.11845139
84AR_20517297_ChIP-Seq_VCAP_Human1.11299262
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10908826
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10314892
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08644384
88DCP1A_22483619_ChIP-Seq_HELA_Human1.08410483
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06325263
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.04753649
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04065434
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03367655
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02495703
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01793433
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01780186
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01514563
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.01407539
98TTF2_22483619_ChIP-Seq_HELA_Human1.00596221
99BCAT_22108803_ChIP-Seq_LS180_Human0.99590864
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98851650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.07112580
2MP0001529_abnormal_vocalization3.54862473
3MP0005671_abnormal_response_to3.39042774
4MP0003806_abnormal_nucleotide_metabolis2.99614127
5MP0004147_increased_porphyrin_level2.83023356
6MP0004142_abnormal_muscle_tone2.78311830
7MP0003436_decreased_susceptibility_to2.42660465
8MP0000569_abnormal_digit_pigmentation2.32993839
9MP0009785_altered_susceptibility_to2.25945573
10MP0002148_abnormal_hypersensitivity_rea2.20948004
11MP0006082_CNS_inflammation2.18867062
12MP0002234_abnormal_pharynx_morphology2.14514779
13MP0006292_abnormal_olfactory_placode2.05694251
14MP0004145_abnormal_muscle_electrophysio2.03683868
15MP0002090_abnormal_vision2.02881676
16MP0000685_abnormal_immune_system2.01809246
17MP0006072_abnormal_retinal_apoptosis1.98590214
18MP0008875_abnormal_xenobiotic_pharmacok1.96180454
19MP0001790_abnormal_immune_system1.93577751
20MP0005387_immune_system_phenotype1.93577751
21MP0008872_abnormal_physiological_respon1.92204942
22MP0005084_abnormal_gallbladder_morpholo1.87894047
23MP0003724_increased_susceptibility_to1.80353683
24MP0006036_abnormal_mitochondrial_physio1.70339434
25MP0005646_abnormal_pituitary_gland1.70052361
26MP0005367_renal/urinary_system_phenotyp1.69606476
27MP0000516_abnormal_urinary_system1.69606476
28MP0005000_abnormal_immune_tolerance1.68385853
29MP0001800_abnormal_humoral_immune1.66512232
30MP0001984_abnormal_olfaction1.65409764
31MP0001440_abnormal_grooming_behavior1.62940737
32MP0005551_abnormal_eye_electrophysiolog1.54928522
33MP0002254_reproductive_system_inflammat1.54445276
34MP0000372_irregular_coat_pigmentation1.54173554
35MP0003186_abnormal_redox_activity1.54116541
36MP0002102_abnormal_ear_morphology1.50764485
37MP0008789_abnormal_olfactory_epithelium1.49132964
38MP0005075_abnormal_melanosome_morpholog1.44285335
39MP0005253_abnormal_eye_physiology1.38368474
40MP0002837_dystrophic_cardiac_calcinosis1.38011301
41MP0009379_abnormal_foot_pigmentation1.37847649
42MP0009764_decreased_sensitivity_to1.36069779
43MP0000371_diluted_coat_color1.35778123
44MP0005645_abnormal_hypothalamus_physiol1.31048467
45MP0002452_abnormal_antigen_presenting1.30727917
46MP0002095_abnormal_skin_pigmentation1.28841468
47MP0001486_abnormal_startle_reflex1.25037498
48MP0005379_endocrine/exocrine_gland_phen1.24048248
49MP0008058_abnormal_DNA_repair1.23034193
50MP0002723_abnormal_immune_serum1.21836307
51MP0002876_abnormal_thyroid_physiology1.21358057
52MP0002938_white_spotting1.20786067
53MP0003137_abnormal_impulse_conducting1.20010100
54MP0001968_abnormal_touch/_nociception1.17277019
55MP0003172_abnormal_lysosome_physiology1.16659338
56MP0003011_delayed_dark_adaptation1.15376200
57MP0005408_hypopigmentation1.14728195
58MP0005171_absent_coat_pigmentation1.13520546
59MP0000647_abnormal_sebaceous_gland1.09917362
60MP0001986_abnormal_taste_sensitivity1.09803401
61MP0009046_muscle_twitch1.09618298
62MP0003567_abnormal_fetal_cardiomyocyte1.09153913
63MP0003195_calcinosis1.06045615
64MP0006035_abnormal_mitochondrial_morpho1.05427397
65MP0004043_abnormal_pH_regulation1.01652991
66MP0005636_abnormal_mineral_homeostasis1.01424006
67MP0002163_abnormal_gland_morphology0.99237059
68MP0001905_abnormal_dopamine_level0.97986254
69MP0001819_abnormal_immune_cell0.97890325
70MP0005535_abnormal_body_temperature0.97646541
71MP0005499_abnormal_olfactory_system0.96015625
72MP0005394_taste/olfaction_phenotype0.96015625
73MP0002006_tumorigenesis0.95035174
74MP0002166_altered_tumor_susceptibility0.94470855
75MP0001919_abnormal_reproductive_system0.93527052
76MP0002420_abnormal_adaptive_immunity0.91857334
77MP0008469_abnormal_protein_level0.91516395
78MP0009333_abnormal_splenocyte_physiolog0.90867612
79MP0001485_abnormal_pinna_reflex0.88935602
80MP0001873_stomach_inflammation0.88774254
81MP0000639_abnormal_adrenal_gland0.86484311
82MP0002075_abnormal_coat/hair_pigmentati0.86191004
83MP0000427_abnormal_hair_cycle0.85012038
84MP0005025_abnormal_response_to0.83999162
85MP0002419_abnormal_innate_immunity0.82865722
86MP0005187_abnormal_penis_morphology0.81760840
87MP0001186_pigmentation_phenotype0.76850220
88MP0001845_abnormal_inflammatory_respons0.75909740
89MP0005503_abnormal_tendon_morphology0.75267899
90MP0002272_abnormal_nervous_system0.74095976
91MP0005670_abnormal_white_adipose0.73675316
92MP0001533_abnormal_skeleton_physiology0.72251349
93MP0001756_abnormal_urination0.71303668
94MP0009745_abnormal_behavioral_response0.69229834
95MP0010155_abnormal_intestine_physiology0.68672190
96MP0004742_abnormal_vestibular_system0.68621758
97MP0000230_abnormal_systemic_arterial0.68188025
98MP0005167_abnormal_blood-brain_barrier0.67674641
99MP0000716_abnormal_immune_system0.67600463
100MP0008873_increased_physiological_sensi0.67138192

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)6.64526482
2Acute necrotizing encephalopathy (HP:0006965)6.45024027
3Abnormal mitochondria in muscle tissue (HP:0008316)5.64889108
4Mitochondrial inheritance (HP:0001427)5.52585244
5Hepatic necrosis (HP:0002605)5.47940504
6Progressive macrocephaly (HP:0004481)5.39470064
7Acute encephalopathy (HP:0006846)5.17291900
8Congenital, generalized hypertrichosis (HP:0004540)5.12379850
9Increased CSF lactate (HP:0002490)4.64834218
10Increased hepatocellular lipid droplets (HP:0006565)4.11075718
11Cerebral edema (HP:0002181)4.10226233
123-Methylglutaconic aciduria (HP:0003535)3.83020711
13Lipid accumulation in hepatocytes (HP:0006561)3.82639020
14Leukodystrophy (HP:0002415)3.80920418
15Hypothermia (HP:0002045)3.46962298
16Multiple enchondromatosis (HP:0005701)3.39746395
17Renal Fanconi syndrome (HP:0001994)3.36116864
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26021452
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26021452
20Exertional dyspnea (HP:0002875)3.23143730
21Optic disc pallor (HP:0000543)3.14083219
22Hypoproteinemia (HP:0003075)3.01508742
23Respiratory failure (HP:0002878)2.89191662
24CNS demyelination (HP:0007305)2.84818553
25Chronic diarrhea (HP:0002028)2.72241309
26Abnormality of the prostate (HP:0008775)2.55133351
27Split foot (HP:0001839)2.54035990
28Obstructive lung disease (HP:0006536)2.53731189
29Chronic obstructive pulmonary disease (HP:0006510)2.53731189
30Increased intramyocellular lipid droplets (HP:0012240)2.49792135
31Lactic acidosis (HP:0003128)2.42736921
32Abnormality of renal resorption (HP:0011038)2.42006161
33Absent hand (HP:0004050)2.39590442
34Cerebellar dysplasia (HP:0007033)2.39196368
35Cleft eyelid (HP:0000625)2.37013339
36Global brain atrophy (HP:0002283)2.35125734
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34157299
38Chronic mucocutaneous candidiasis (HP:0002728)2.32681665
39Recurrent cutaneous fungal infections (HP:0011370)2.32681665
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30773572
41Type II lissencephaly (HP:0007260)2.30355579
42Increased serum lactate (HP:0002151)2.27291510
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23059113
44Aplastic anemia (HP:0001915)2.22079790
45Rectovaginal fistula (HP:0000143)2.21190299
46Rectal fistula (HP:0100590)2.21190299
47Pancreatic cysts (HP:0001737)2.17532503
48Abolished electroretinogram (ERG) (HP:0000550)2.16492756
49Pulmonary fibrosis (HP:0002206)2.15344237
50Woolly hair (HP:0002224)2.14640509
51Aplasia/hypoplasia of the uterus (HP:0008684)2.11204915
52Abnormality of midbrain morphology (HP:0002418)2.08876887
53Molar tooth sign on MRI (HP:0002419)2.08876887
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.08534706
55Increased muscle lipid content (HP:0009058)2.06314968
56Abnormality of lateral ventricle (HP:0030047)2.06295663
57Exercise intolerance (HP:0003546)2.05149701
58Blindness (HP:0000618)2.04535862
59Hemoptysis (HP:0002105)2.04216621
60Stomatitis (HP:0010280)2.03739001
61Chest pain (HP:0100749)2.00895456
62Emotional lability (HP:0000712)2.00368075
63Concave nail (HP:0001598)1.99124381
64Medial flaring of the eyebrow (HP:0010747)1.97648712
65Ureteral obstruction (HP:0006000)1.95552067
66Attenuation of retinal blood vessels (HP:0007843)1.95442237
67Pruritus (HP:0000989)1.93367642
68Premature loss of primary teeth (HP:0006323)1.91117478
69Respiratory difficulties (HP:0002880)1.90791125
70Nephronophthisis (HP:0000090)1.90480410
71Abnormal rod and cone electroretinograms (HP:0008323)1.89891063
72X-linked dominant inheritance (HP:0001423)1.88794432
73Pulmonary infiltrates (HP:0002113)1.88229285
74IgG deficiency (HP:0004315)1.87885941
75Abnormality of the renal cortex (HP:0011035)1.87712160
76Agammaglobulinemia (HP:0004432)1.87216702
77Abnormality of the renal medulla (HP:0100957)1.86875405
78Abnormality of the anterior horn cell (HP:0006802)1.82131133
79Degeneration of anterior horn cells (HP:0002398)1.82131133
80Lethargy (HP:0001254)1.81794758
81Amaurosis fugax (HP:0100576)1.79541556
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75871345
83Decreased central vision (HP:0007663)1.75445608
84Increased cerebral lipofuscin (HP:0011813)1.73927131
85Vaginal fistula (HP:0004320)1.73272786
86Abnormality of the pleura (HP:0002103)1.72503461
87Congenital stationary night blindness (HP:0007642)1.71904818
88Parakeratosis (HP:0001036)1.71551795
89Septate vagina (HP:0001153)1.69405007
90Hypoplasia of the pons (HP:0012110)1.68085662
91Abnormality of the pons (HP:0007361)1.66580768
92Amniotic constriction ring (HP:0009775)1.63843608
93Abnormality of placental membranes (HP:0011409)1.63843608
94Intestinal fistula (HP:0100819)1.62654439
95Meningitis (HP:0001287)1.61208728
96Periodontitis (HP:0000704)1.59113618
97Cerebral palsy (HP:0100021)1.57814704
98Ureteral stenosis (HP:0000071)1.57461342
99Hyperglycinemia (HP:0002154)1.56590467
100Delayed CNS myelination (HP:0002188)1.55493048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.08108559
2BMPR23.53017737
3MST43.14081961
4MAP3K132.88425537
5MAP4K22.62063331
6TLK12.59965210
7STK38L2.51303393
8VRK22.50610821
9MYLK2.27817457
10CDK191.99960516
11FRK1.97076199
12SRPK11.93335442
13MAP3K141.91613325
14TAOK31.80975048
15TXK1.78863517
16ADRBK21.69856843
17MAP3K41.53935135
18CSF1R1.41323617
19ILK1.39795738
20ZAK1.39638766
21INSRR1.39337754
22DAPK11.32651958
23CDK31.32142927
24VRK11.28002992
25NUAK11.25442623
26STK241.23144938
27RPS6KA41.20217694
28CSNK1G31.19853143
29OBSCN1.17592738
30IKBKB1.17236172
31GRK11.15950488
32ERBB31.15661243
33MKNK11.13842455
34MAP4K11.13360417
35CSNK1A1L1.13027353
36FLT31.10216067
37PHKG21.07738145
38PHKG11.07738145
39MKNK21.06922064
40CSNK1G21.06908569
41CDK81.04731235
42OXSR11.04610705
43BLK1.04363952
44WNK41.01862608
45DAPK30.99360589
46CSNK1G10.97555037
47KIT0.95461981
48MAP2K60.93292966
49LYN0.88830513
50STK30.86536983
51WNK30.86086390
52PRKCE0.86022449
53PIK3CG0.81758417
54TAF10.77852299
55TIE10.77711501
56GRK70.76305568
57TYK20.75886617
58CCNB10.73367423
59CSNK2A20.71858592
60DYRK20.70255790
61KDR0.69748001
62NEK10.69413973
63SYK0.68533993
64BCKDK0.68402700
65TNK20.67245568
66TRPM70.66966999
67STK390.64763860
68SCYL20.63121723
69PINK10.63023393
70EGFR0.61609540
71RPS6KA50.61334340
72TEC0.59252001
73EPHA30.57575611
74ACVR1B0.56808874
75PRKG10.56397616
76CASK0.56087899
77ADRBK10.54711549
78PIK3CA0.53822869
79TRIM280.52928738
80IGF1R0.51533692
81CAMK2A0.51202492
82CSNK2A10.50757456
83PLK30.50689915
84AURKB0.50431626
85CAMK2D0.48252422
86CSNK1E0.47074764
87MAP2K70.44226183
88CHUK0.43392615
89PNCK0.41530489
90MATK0.41464650
91PRKACA0.41313199
92ATR0.41181920
93MAPK130.39809693
94CLK10.39803422
95DYRK30.39622004
96MAP3K70.39241145
97LCK0.38557434
98ATM0.38076052
99SGK10.37595462
100GRK50.36256134

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.69547504
2Graft-versus-host disease_Homo sapiens_hsa053324.18344548
3Oxidative phosphorylation_Homo sapiens_hsa001903.87632597
4Allograft rejection_Homo sapiens_hsa053303.59579918
5Autoimmune thyroid disease_Homo sapiens_hsa053203.42093698
6Protein export_Homo sapiens_hsa030603.27504777
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.20944386
8Parkinsons disease_Homo sapiens_hsa050123.17874040
9Type I diabetes mellitus_Homo sapiens_hsa049403.15601428
10Proteasome_Homo sapiens_hsa030502.75195015
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71498186
12Ribosome_Homo sapiens_hsa030102.33908802
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32939742
14Antigen processing and presentation_Homo sapiens_hsa046122.27445439
15Alzheimers disease_Homo sapiens_hsa050102.27141084
16Rheumatoid arthritis_Homo sapiens_hsa053232.16452508
17Huntingtons disease_Homo sapiens_hsa050162.11465623
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.09924395
19Cardiac muscle contraction_Homo sapiens_hsa042601.86862669
20Caffeine metabolism_Homo sapiens_hsa002321.83048484
21Staphylococcus aureus infection_Homo sapiens_hsa051501.75506723
22RNA polymerase_Homo sapiens_hsa030201.71305231
23Viral myocarditis_Homo sapiens_hsa054161.65978762
24Leishmaniasis_Homo sapiens_hsa051401.55099115
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46799491
26Homologous recombination_Homo sapiens_hsa034401.44482328
27Phototransduction_Homo sapiens_hsa047441.27394207
28RNA degradation_Homo sapiens_hsa030181.18628076
29Nucleotide excision repair_Homo sapiens_hsa034201.16244475
30Fanconi anemia pathway_Homo sapiens_hsa034601.01131629
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99288180
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97251910
33Systemic lupus erythematosus_Homo sapiens_hsa053220.97038251
34Hematopoietic cell lineage_Homo sapiens_hsa046400.91626282
35NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78927571
36Collecting duct acid secretion_Homo sapiens_hsa049660.76422824
37Glycosaminoglycan degradation_Homo sapiens_hsa005310.76268260
38Non-homologous end-joining_Homo sapiens_hsa034500.75796477
39Tryptophan metabolism_Homo sapiens_hsa003800.74857425
40DNA replication_Homo sapiens_hsa030300.73738317
41RNA transport_Homo sapiens_hsa030130.70972579
42Spliceosome_Homo sapiens_hsa030400.69488766
43Basal transcription factors_Homo sapiens_hsa030220.67864123
44Toxoplasmosis_Homo sapiens_hsa051450.65650996
45Primary immunodeficiency_Homo sapiens_hsa053400.65522885
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.65492578
47Linoleic acid metabolism_Homo sapiens_hsa005910.62905871
48Pyrimidine metabolism_Homo sapiens_hsa002400.60951819
49Epstein-Barr virus infection_Homo sapiens_hsa051690.60591430
50Phagosome_Homo sapiens_hsa041450.59513251
51Mismatch repair_Homo sapiens_hsa034300.59321258
52Purine metabolism_Homo sapiens_hsa002300.57169764
53Regulation of autophagy_Homo sapiens_hsa041400.56927605
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54632364
55Herpes simplex infection_Homo sapiens_hsa051680.52577017
56One carbon pool by folate_Homo sapiens_hsa006700.50789093
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.50402613
58Tuberculosis_Homo sapiens_hsa051520.49536181
59Influenza A_Homo sapiens_hsa051640.49014812
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46506086
61Olfactory transduction_Homo sapiens_hsa047400.43856281
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42920109
63Chemical carcinogenesis_Homo sapiens_hsa052040.42033146
64Nicotine addiction_Homo sapiens_hsa050330.40499417
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40453016
66Phenylalanine metabolism_Homo sapiens_hsa003600.39386368
67Tyrosine metabolism_Homo sapiens_hsa003500.39125659
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.36319380
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35719863
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33930455
71Pertussis_Homo sapiens_hsa051330.32474717
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31550734
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30790741
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30315974
75Legionellosis_Homo sapiens_hsa051340.29632481
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29042655
77Base excision repair_Homo sapiens_hsa034100.28639597
78Metabolic pathways_Homo sapiens_hsa011000.27890501
79Arachidonic acid metabolism_Homo sapiens_hsa005900.27015980
80Salmonella infection_Homo sapiens_hsa051320.27005339
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26986445
82Peroxisome_Homo sapiens_hsa041460.23559858
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22296009
84Salivary secretion_Homo sapiens_hsa049700.22136255
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.20960337
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19929159
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19890521
88Glutathione metabolism_Homo sapiens_hsa004800.17130948
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.16474310
90African trypanosomiasis_Homo sapiens_hsa051430.16310975
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16115150
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16004633
93Folate biosynthesis_Homo sapiens_hsa007900.14904630
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.09805030
95GABAergic synapse_Homo sapiens_hsa047270.08950030
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08584039
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08099540
98Mineral absorption_Homo sapiens_hsa049780.08091810
99Osteoclast differentiation_Homo sapiens_hsa043800.07182322
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.06932981

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