SUMO2P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.73710546
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.15559806
3ATP synthesis coupled proton transport (GO:0015986)6.15559806
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.99854885
5viral mRNA export from host cell nucleus (GO:0046784)5.47086388
6DNA deamination (GO:0045006)4.86518169
7proteasome assembly (GO:0043248)4.82295852
8protein polyglutamylation (GO:0018095)4.58083137
9regulation of cilium movement (GO:0003352)4.49098876
10platelet dense granule organization (GO:0060155)4.34193874
11activated T cell proliferation (GO:0050798)4.26644207
12respiratory electron transport chain (GO:0022904)4.25692629
13negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.17316779
14electron transport chain (GO:0022900)4.17230146
15histone arginine methylation (GO:0034969)4.02037580
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.99283477
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.98438401
18maturation of SSU-rRNA (GO:0030490)3.96890167
19intra-S DNA damage checkpoint (GO:0031573)3.95675266
20inner mitochondrial membrane organization (GO:0007007)3.91387925
21positive regulation of prostaglandin secretion (GO:0032308)3.78227748
22protein neddylation (GO:0045116)3.77673470
23ribosomal small subunit biogenesis (GO:0042274)3.68704657
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.64393217
25cytidine metabolic process (GO:0046087)3.57656105
26cytidine catabolic process (GO:0006216)3.57656105
27cytidine deamination (GO:0009972)3.57656105
28forebrain neuron differentiation (GO:0021879)3.56882344
29cell migration involved in gastrulation (GO:0042074)3.51243950
30hydrogen ion transmembrane transport (GO:1902600)3.46674943
31NAD biosynthetic process (GO:0009435)3.45373145
32male sex determination (GO:0030238)3.45332817
33ATP biosynthetic process (GO:0006754)3.43100689
34spliceosomal snRNP assembly (GO:0000387)3.43011488
35replication fork processing (GO:0031297)3.41797657
36positive regulation of mitochondrial fission (GO:0090141)3.40666547
37regulation of prostaglandin secretion (GO:0032306)3.35633414
38DNA integration (GO:0015074)3.35266290
39microtubule severing (GO:0051013)3.29974676
40molting cycle (GO:0042303)3.29371139
41hair cycle (GO:0042633)3.29371139
42viral transcription (GO:0019083)3.26618151
43termination of RNA polymerase III transcription (GO:0006386)3.25776603
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.25776603
45replicative senescence (GO:0090399)3.21751088
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20778197
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18761023
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.18761023
49NADH dehydrogenase complex assembly (GO:0010257)3.18761023
50nicotinamide nucleotide biosynthetic process (GO:0019359)3.17178886
51pyridine nucleotide biosynthetic process (GO:0019363)3.17178886
52protein complex biogenesis (GO:0070271)3.17126569
53maturation of 5.8S rRNA (GO:0000460)3.16326421
54regulation of mesenchymal cell apoptotic process (GO:2001053)3.15392345
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15067950
56translational termination (GO:0006415)3.13979080
57innate immune response in mucosa (GO:0002227)3.12185612
58ribosomal large subunit biogenesis (GO:0042273)3.12116464
59regulation of microtubule-based movement (GO:0060632)3.11231974
60negative regulation of telomerase activity (GO:0051974)3.10916120
61regulation of nuclear cell cycle DNA replication (GO:0033262)3.10894779
62behavioral response to nicotine (GO:0035095)3.09414097
63otic vesicle formation (GO:0030916)3.09190504
64proton transport (GO:0015992)3.06220002
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04600523
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04152330
67establishment of integrated proviral latency (GO:0075713)3.03758515
68rRNA modification (GO:0000154)3.01797921
69mitochondrial respiratory chain complex assembly (GO:0033108)3.00503286
70DNA replication checkpoint (GO:0000076)2.99203771
71hydrogen transport (GO:0006818)2.98696961
72hematopoietic stem cell proliferation (GO:0071425)2.98246480
73L-alpha-amino acid transmembrane transport (GO:1902475)2.96525156
74purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96507942
75nucleotide-excision repair, DNA gap filling (GO:0006297)2.90702740
76intracellular protein transmembrane import (GO:0044743)2.89670291
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87423875
78cellular component biogenesis (GO:0044085)2.86916407
79ribonucleoprotein complex biogenesis (GO:0022613)2.85361165
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.84253339
81protein localization to mitochondrion (GO:0070585)2.81003321
82ribosomal small subunit assembly (GO:0000028)2.79729819
83regulation of cellular amino acid metabolic process (GO:0006521)2.78748321
84establishment of protein localization to mitochondrion (GO:0072655)2.78503947
85establishment of viral latency (GO:0019043)2.78136745
86cotranslational protein targeting to membrane (GO:0006613)2.77516574
87regulation of helicase activity (GO:0051095)2.77116422
88translational elongation (GO:0006414)2.77097857
89DNA replication-dependent nucleosome assembly (GO:0006335)2.76185054
90DNA replication-dependent nucleosome organization (GO:0034723)2.76185054
91regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.75850171
92IMP biosynthetic process (GO:0006188)2.74844927
93chaperone-mediated protein transport (GO:0072321)2.73947151
94purine nucleobase biosynthetic process (GO:0009113)2.73325518
95telomere maintenance via telomere lengthening (GO:0010833)2.73297706
96pyrimidine ribonucleoside catabolic process (GO:0046133)2.71523868
97regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71456600
98cellular response to pH (GO:0071467)2.70242974
99negative regulation of ligase activity (GO:0051352)2.69717658
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69717658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.35451912
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.54500907
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.22921192
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81414024
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79915552
6E2F7_22180533_ChIP-Seq_HELA_Human2.76314882
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.67595800
8POU5F1_16153702_ChIP-ChIP_HESCs_Human2.67550228
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54934342
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51559875
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45579495
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39333608
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32605981
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32594913
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.29636660
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27389930
17ELK1_19687146_ChIP-ChIP_HELA_Human2.23969389
18VDR_23849224_ChIP-Seq_CD4+_Human2.18149207
19IRF1_19129219_ChIP-ChIP_H3396_Human2.17423002
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.17318351
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13882894
22SOX2_16153702_ChIP-ChIP_HESCs_Human2.13288807
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.13229649
24FOXP3_21729870_ChIP-Seq_TREG_Human2.03617579
25IGF1R_20145208_ChIP-Seq_DFB_Human1.94379141
26VDR_22108803_ChIP-Seq_LS180_Human1.90395998
27ZNF274_21170338_ChIP-Seq_K562_Hela1.83182547
28NANOG_16153702_ChIP-ChIP_HESCs_Human1.78431668
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74026855
30EWS_26573619_Chip-Seq_HEK293_Human1.70277444
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68295221
32MYC_18940864_ChIP-ChIP_HL60_Human1.66532924
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.65531463
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65379301
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65123262
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64405757
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64024869
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49641551
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49271586
40TTF2_22483619_ChIP-Seq_HELA_Human1.43211949
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42442094
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41217547
43BCAT_22108803_ChIP-Seq_LS180_Human1.41117579
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40321216
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37938863
46P300_19829295_ChIP-Seq_ESCs_Human1.37092077
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36790858
48DCP1A_22483619_ChIP-Seq_HELA_Human1.36446551
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33111546
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33003269
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32714010
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32527277
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.31751020
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30873804
55XRN2_22483619_ChIP-Seq_HELA_Human1.30091836
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28154271
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26888029
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23562639
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20764847
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20489705
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20264150
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19485574
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19388249
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15936346
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15480872
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14412963
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13492684
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.12679205
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09287391
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06781515
71HTT_18923047_ChIP-ChIP_STHdh_Human1.05742887
72RNF2_27304074_Chip-Seq_NSC_Mouse1.03254471
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02881355
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01603945
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01312464
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01312464
77GABP_19822575_ChIP-Seq_HepG2_Human1.00771075
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00552275
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99573292
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98494206
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97621250
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95174143
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94853804
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93784551
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93430265
86ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93374402
87TP53_22573176_ChIP-Seq_HFKS_Human0.93297986
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92182851
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91746340
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91351694
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.90624630
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88266940
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88027645
94JUN_21703547_ChIP-Seq_K562_Human0.87863480
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85340179
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.85340179
97ERG_20517297_ChIP-Seq_VCAP_Human0.84564078
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.83930644
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83166775
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82666435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.21264319
2MP0001502_abnormal_circadian_rhythm3.15650947
3MP0006292_abnormal_olfactory_placode3.14050183
4MP0004885_abnormal_endolymph3.00004300
5MP0002163_abnormal_gland_morphology2.75673901
6MP0001485_abnormal_pinna_reflex2.70928528
7MP0003878_abnormal_ear_physiology2.64936938
8MP0005377_hearing/vestibular/ear_phenot2.64936938
9MP0002653_abnormal_ependyma_morphology2.61159921
10MP0001188_hyperpigmentation2.55453523
11MP0003122_maternal_imprinting2.43995467
12MP0003941_abnormal_skin_development2.39112984
13MP0002736_abnormal_nociception_after2.19809372
14MP0002254_reproductive_system_inflammat2.08197071
15MP0005379_endocrine/exocrine_gland_phen2.06946183
16MP0000566_synostosis1.94576087
17MP0005671_abnormal_response_to1.88476263
18MP0005645_abnormal_hypothalamus_physiol1.82276490
19MP0002638_abnormal_pupillary_reflex1.77620319
20MP0000537_abnormal_urethra_morphology1.77068346
21MP0004957_abnormal_blastocyst_morpholog1.76272956
22MP0000049_abnormal_middle_ear1.71727426
23MP0003315_abnormal_perineum_morphology1.69885779
24MP0008872_abnormal_physiological_respon1.65089830
25MP0009764_decreased_sensitivity_to1.63653952
26MP0008058_abnormal_DNA_repair1.63646453
27MP0002102_abnormal_ear_morphology1.61178800
28MP0010094_abnormal_chromosome_stability1.61120840
29MP0001905_abnormal_dopamine_level1.59309774
30MP0003938_abnormal_ear_development1.57424032
31MP0001984_abnormal_olfaction1.54849166
32MP0008877_abnormal_DNA_methylation1.53858353
33MP0006276_abnormal_autonomic_nervous1.51115617
34MP0003567_abnormal_fetal_cardiomyocyte1.49321137
35MP0004742_abnormal_vestibular_system1.47570580
36MP0003119_abnormal_digestive_system1.42892985
37MP0001968_abnormal_touch/_nociception1.41005633
38MP0003136_yellow_coat_color1.40950530
39MP0000631_abnormal_neuroendocrine_gland1.40487308
40MP0005551_abnormal_eye_electrophysiolog1.36402388
41MP0006072_abnormal_retinal_apoptosis1.35665119
42MP0003011_delayed_dark_adaptation1.34737910
43MP0001529_abnormal_vocalization1.34197214
44MP0002837_dystrophic_cardiac_calcinosis1.33233285
45MP0005085_abnormal_gallbladder_physiolo1.32083168
46MP0003937_abnormal_limbs/digits/tail_de1.26951571
47MP0005084_abnormal_gallbladder_morpholo1.25320214
48MP0001346_abnormal_lacrimal_gland1.17888511
49MP0004142_abnormal_muscle_tone1.17547854
50MP0001790_abnormal_immune_system1.11047400
51MP0005387_immune_system_phenotype1.11047400
52MP0004215_abnormal_myocardial_fiber1.09633102
53MP0003195_calcinosis1.07648506
54MP0001835_abnormal_antigen_presentation1.06954045
55MP0001348_abnormal_lacrimal_gland1.06393585
56MP0005253_abnormal_eye_physiology1.05341345
57MP0000383_abnormal_hair_follicle1.00677763
58MP0005410_abnormal_fertilization0.97808195
59MP0001873_stomach_inflammation0.97262498
60MP0009384_cardiac_valve_regurgitation0.95685631
61MP0000579_abnormal_nail_morphology0.92863223
62MP0005195_abnormal_posterior_eye0.89866108
63MP0002277_abnormal_respiratory_mucosa0.89443877
64MP0002138_abnormal_hepatobiliary_system0.89120176
65MP0004197_abnormal_fetal_growth/weight/0.88515488
66MP0001986_abnormal_taste_sensitivity0.88313512
67MP0003693_abnormal_embryo_hatching0.88285671
68MP0008770_decreased_survivor_rate0.87695998
69MP0002210_abnormal_sex_determination0.86153217
70MP0000778_abnormal_nervous_system0.84989844
71MP0001919_abnormal_reproductive_system0.84539867
72MP0003111_abnormal_nucleus_morphology0.83737669
73MP0001929_abnormal_gametogenesis0.82172823
74MP0000685_abnormal_immune_system0.81239737
75MP0003763_abnormal_thymus_physiology0.80926824
76MP0003077_abnormal_cell_cycle0.80889344
77MP0001293_anophthalmia0.80798059
78MP0000516_abnormal_urinary_system0.79606112
79MP0005367_renal/urinary_system_phenotyp0.79606112
80MP0002272_abnormal_nervous_system0.79471030
81MP0000427_abnormal_hair_cycle0.79257496
82MP0004084_abnormal_cardiac_muscle0.78948481
83MP0002751_abnormal_autonomic_nervous0.77730127
84MP0001764_abnormal_homeostasis0.77368590
85MP0001963_abnormal_hearing_physiology0.77191092
86MP0002752_abnormal_somatic_nervous0.77102146
87MP0002282_abnormal_trachea_morphology0.76190911
88MP0002166_altered_tumor_susceptibility0.76171175
89MP0009745_abnormal_behavioral_response0.75933429
90MP0009780_abnormal_chondrocyte_physiolo0.75464956
91MP0003121_genomic_imprinting0.74104218
92MP0008932_abnormal_embryonic_tissue0.73405402
93MP0006035_abnormal_mitochondrial_morpho0.73102839
94MP0001853_heart_inflammation0.72159830
95MP0002249_abnormal_larynx_morphology0.70379610
96MP0002064_seizures0.68559898
97MP0008007_abnormal_cellular_replicative0.68084077
98MP0002938_white_spotting0.67939899
99MP0003698_abnormal_male_reproductive0.63012036
100MP0000653_abnormal_sex_gland0.62999546

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)5.45036779
2Increased hepatocellular lipid droplets (HP:0006565)4.54260334
3Acute necrotizing encephalopathy (HP:0006965)4.33544792
4Lipid accumulation in hepatocytes (HP:0006561)3.97817939
5Progressive macrocephaly (HP:0004481)3.95824956
6Mutism (HP:0002300)3.88817064
7Abnormal mitochondria in muscle tissue (HP:0008316)3.78582501
8Spastic diplegia (HP:0001264)3.55646007
9Mitochondrial inheritance (HP:0001427)3.54487001
10Carpal bone hypoplasia (HP:0001498)3.52850912
11Depressed nasal tip (HP:0000437)3.51457314
12Abnormality of the middle phalanges of the toes (HP:0010183)3.49878678
13Acute encephalopathy (HP:0006846)3.49534602
14Renal cortical cysts (HP:0000803)3.40648680
15Leukodystrophy (HP:0002415)3.30421974
16Septo-optic dysplasia (HP:0100842)3.28618480
17Abnormality of the proximal phalanges of the hand (HP:0009834)3.26239982
18Increased CSF lactate (HP:0002490)3.23623293
19Renal Fanconi syndrome (HP:0001994)3.22465251
20Absent septum pellucidum (HP:0001331)3.22097293
21Abnormality of the septum pellucidum (HP:0007375)3.16878505
22Abnormality of the phalanges of the 2nd finger (HP:0009541)3.07589032
23Increased intramyocellular lipid droplets (HP:0012240)2.99697255
24Flat capital femoral epiphysis (HP:0003370)2.87962384
25Exertional dyspnea (HP:0002875)2.87212734
26Hypoplasia of the pons (HP:0012110)2.79802437
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77237216
28Reticulocytopenia (HP:0001896)2.67731238
29Cerebral edema (HP:0002181)2.67526712
30Hemiplegia (HP:0002301)2.67437196
31Autoimmune thrombocytopenia (HP:0001973)2.66289328
32Testicular atrophy (HP:0000029)2.56035546
33Abnormality of the pons (HP:0007361)2.53117576
34Humeroradial synostosis (HP:0003041)2.47079678
35Synostosis involving the elbow (HP:0003938)2.47079678
36Progressive sensorineural hearing impairment (HP:0000408)2.43486487
37Abnormal number of erythroid precursors (HP:0012131)2.40314273
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38910116
39Increased muscle lipid content (HP:0009058)2.35772012
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33873442
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33873442
42Reduced antithrombin III activity (HP:0001976)2.32941205
43Cerebellar dysplasia (HP:0007033)2.29931826
44Inability to walk (HP:0002540)2.27430618
45Confusion (HP:0001289)2.27251715
46Aplasia/Hypoplasia of the patella (HP:0006498)2.24907159
47Megalencephaly (HP:0001355)2.24152956
48Abnormality of urine glucose concentration (HP:0011016)2.21948765
49Glycosuria (HP:0003076)2.21948765
50Degeneration of anterior horn cells (HP:0002398)2.21867318
51Abnormality of the anterior horn cell (HP:0006802)2.21867318
52Autoimmune hemolytic anemia (HP:0001890)2.20773327
53Vertebral fusion (HP:0002948)2.19477133
54Abnormality of the renal cortex (HP:0011035)2.19470272
55Hepatic necrosis (HP:0002605)2.18671094
56Optic disc pallor (HP:0000543)2.16270826
57Short hallux (HP:0010109)2.15589892
58Abnormality of cells of the erythroid lineage (HP:0012130)2.15273599
59Abnormality of renal resorption (HP:0011038)2.14524374
60Macrocytic anemia (HP:0001972)2.14397662
61Increased serum lactate (HP:0002151)2.12455043
62Patellar aplasia (HP:0006443)2.11266748
63Exercise intolerance (HP:0003546)2.10779047
64Morphological abnormality of the middle ear (HP:0008609)2.10681676
65Lactic acidosis (HP:0003128)2.09283918
66Aplasia/Hypoplasia of the hallux (HP:0008362)2.09262573
67Rough bone trabeculation (HP:0100670)2.07010023
68Anomalous pulmonary venous return (HP:0010772)2.03765486
69Maternal diabetes (HP:0009800)2.00410190
70Morphological abnormality of the inner ear (HP:0011390)1.99021076
712-3 toe syndactyly (HP:0004691)1.95981529
72Birth length less than 3rd percentile (HP:0003561)1.94932096
73Supernumerary spleens (HP:0009799)1.94016434
74Chronic bronchitis (HP:0004469)1.93242872
75Hypogonadotrophic hypogonadism (HP:0000044)1.93112206
76Hemivertebrae (HP:0002937)1.90748006
77Hepatocellular necrosis (HP:0001404)1.90432666
78Respiratory difficulties (HP:0002880)1.89427974
79Shoulder girdle muscle weakness (HP:0003547)1.88332149
80Tetraparesis (HP:0002273)1.87945408
81Morphological abnormality of the pyramidal tract (HP:0002062)1.87908534
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.86213765
83Long nose (HP:0003189)1.83516486
84Upper motor neuron abnormality (HP:0002127)1.81703483
85Abnormality of methionine metabolism (HP:0010901)1.81153823
86Hyperphosphaturia (HP:0003109)1.79398038
87Type II lissencephaly (HP:0007260)1.79290630
88Cellular immunodeficiency (HP:0005374)1.79268686
89Abnormality of the 2nd finger (HP:0004100)1.79177705
90Abnormality of glycolysis (HP:0004366)1.78187015
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75922310
92Poor head control (HP:0002421)1.75919063
93Progressive inability to walk (HP:0002505)1.75653362
94Stenosis of the external auditory canal (HP:0000402)1.72817906
95Proximal amyotrophy (HP:0007126)1.71482676
96Generalized aminoaciduria (HP:0002909)1.71398414
97Methylmalonic acidemia (HP:0002912)1.70397528
98Hypoglycemic coma (HP:0001325)1.70307366
99Sparse lateral eyebrow (HP:0005338)1.69561579
100Abnormality of the pulmonary veins (HP:0011718)1.69516567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR9.69972000
2MUSK6.07596593
3TLK13.40661830
4ZAK3.32710689
5WNK43.08839071
6VRK13.07135394
7TNIK2.83512486
8MAP3K42.65803462
9MAP2K72.17663054
10BUB11.91779669
11VRK21.90166091
12TXK1.81427462
13BLK1.66914237
14STK391.54026932
15EIF2AK31.53717193
16PBK1.37921770
17CDC71.27488539
18CASK1.26081127
19CDK191.26014827
20SRPK11.13122431
21NEK11.12378918
22DAPK31.09576070
23NLK1.09133712
24DYRK21.08272436
25BRSK21.03995105
26RPS6KA50.97804085
27NUAK10.97452465
28MAP4K20.91741500
29BMPR1B0.90623329
30NEK20.89174424
31MST40.86566048
32EPHA30.84050184
33OXSR10.83609629
34ADRBK20.80113839
35ALK0.78675527
36GRK10.75951746
37DYRK30.73581333
38TAF10.73475526
39MAP2K40.72858053
40MAP2K60.72317671
41BMPR20.70216057
42CSNK1G30.67771195
43STK160.65054950
44PINK10.64956212
45TIE10.62236606
46AURKA0.61983260
47TSSK60.61034238
48RIPK10.60802887
49DAPK20.60787859
50CAMKK20.60285606
51PLK30.59272170
52CHEK20.57918276
53MAPKAPK50.52173082
54CSNK1G20.51778011
55LATS10.49098746
56BRSK10.47501839
57NME10.46833540
58PRKCQ0.45861233
59CSNK1G10.43585851
60UHMK10.42907447
61AURKB0.42897571
62PIK3CG0.42029716
63TYRO30.41329544
64MAPK70.36110798
65EIF2AK10.35307598
66RPS6KA40.34514375
67CSNK1A1L0.33814499
68MKNK20.33340128
69PLK40.33120406
70STK40.30238680
71FGFR10.29706627
72CSNK2A10.29233254
73BCR0.28817444
74IRAK40.26895915
75MARK10.25988517
76PLK10.25563423
77LMTK20.23884118
78PRKCE0.23510352
79MYLK0.23315920
80PLK20.21943230
81BCKDK0.21605606
82MAPK120.21353828
83CSNK1A10.21168608
84CSNK2A20.19984625
85SMG10.19952871
86PIM10.18922100
87PRKCG0.18842512
88MAP4K10.18688082
89PKN10.17456542
90TESK10.17372930
91ILK0.16784086
92PNCK0.16294558
93FES0.16154639
94ACVR1B0.15146997
95IRAK10.15109949
96FGFR40.14283966
97SYK0.14174485
98MKNK10.14030214
99PHKG10.12364347
100PHKG20.12364347

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.43171515
2Systemic lupus erythematosus_Homo sapiens_hsa053224.12670218
3Proteasome_Homo sapiens_hsa030503.96528223
4Parkinsons disease_Homo sapiens_hsa050123.94104079
5Ribosome_Homo sapiens_hsa030103.71263011
6Huntingtons disease_Homo sapiens_hsa050162.71154778
7Cardiac muscle contraction_Homo sapiens_hsa042602.64760779
8Alcoholism_Homo sapiens_hsa050342.52007838
9Alzheimers disease_Homo sapiens_hsa050102.38659344
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.33049745
11DNA replication_Homo sapiens_hsa030302.12114051
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05450787
13Mismatch repair_Homo sapiens_hsa034301.98884742
14Spliceosome_Homo sapiens_hsa030401.96066467
15RNA polymerase_Homo sapiens_hsa030201.91720068
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88287221
17Basal transcription factors_Homo sapiens_hsa030221.82556241
18Nucleotide excision repair_Homo sapiens_hsa034201.80977663
19Homologous recombination_Homo sapiens_hsa034401.56949521
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53674945
21Graft-versus-host disease_Homo sapiens_hsa053321.51838633
22Phototransduction_Homo sapiens_hsa047441.43366164
23Antigen processing and presentation_Homo sapiens_hsa046121.40751817
24RNA transport_Homo sapiens_hsa030131.39666249
25RNA degradation_Homo sapiens_hsa030181.38452874
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37913700
27Allograft rejection_Homo sapiens_hsa053301.35462621
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32901353
29Type I diabetes mellitus_Homo sapiens_hsa049401.32813629
30Asthma_Homo sapiens_hsa053101.31290456
31Ether lipid metabolism_Homo sapiens_hsa005651.20417005
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17655138
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11881879
34Autoimmune thyroid disease_Homo sapiens_hsa053201.11063421
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04393810
36Steroid biosynthesis_Homo sapiens_hsa001001.03677165
37Linoleic acid metabolism_Homo sapiens_hsa005910.96574756
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95623863
39Galactose metabolism_Homo sapiens_hsa000520.95129970
40Base excision repair_Homo sapiens_hsa034100.91275764
41Vitamin digestion and absorption_Homo sapiens_hsa049770.90108609
42Protein export_Homo sapiens_hsa030600.89803152
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81703427
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81485032
45Purine metabolism_Homo sapiens_hsa002300.80801570
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79611694
47Pyruvate metabolism_Homo sapiens_hsa006200.79495330
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78752228
49Pyrimidine metabolism_Homo sapiens_hsa002400.74796128
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.72119090
51Non-homologous end-joining_Homo sapiens_hsa034500.70192916
52Primary immunodeficiency_Homo sapiens_hsa053400.68557216
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68267243
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65815785
55Viral carcinogenesis_Homo sapiens_hsa052030.64601549
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61563658
57Tryptophan metabolism_Homo sapiens_hsa003800.59551113
58Glutathione metabolism_Homo sapiens_hsa004800.56645063
59Nitrogen metabolism_Homo sapiens_hsa009100.56356212
60Sulfur metabolism_Homo sapiens_hsa009200.55526284
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54383031
62Fat digestion and absorption_Homo sapiens_hsa049750.53351072
63Metabolic pathways_Homo sapiens_hsa011000.52800384
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.51620177
65Retinol metabolism_Homo sapiens_hsa008300.47018196
66Arginine and proline metabolism_Homo sapiens_hsa003300.46491768
67GABAergic synapse_Homo sapiens_hsa047270.44723469
68Olfactory transduction_Homo sapiens_hsa047400.44444488
69Biosynthesis of amino acids_Homo sapiens_hsa012300.44247472
70Cell cycle_Homo sapiens_hsa041100.42636134
71Pentose phosphate pathway_Homo sapiens_hsa000300.41702665
72Propanoate metabolism_Homo sapiens_hsa006400.40283890
73Phenylalanine metabolism_Homo sapiens_hsa003600.40097427
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39589060
75Rheumatoid arthritis_Homo sapiens_hsa053230.39235165
76Epstein-Barr virus infection_Homo sapiens_hsa051690.37942498
77Tyrosine metabolism_Homo sapiens_hsa003500.36684874
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36438769
79Butanoate metabolism_Homo sapiens_hsa006500.34516133
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34266153
81Circadian rhythm_Homo sapiens_hsa047100.34039756
82mRNA surveillance pathway_Homo sapiens_hsa030150.33439541
83Sulfur relay system_Homo sapiens_hsa041220.32162478
84Morphine addiction_Homo sapiens_hsa050320.31827337
85Carbon metabolism_Homo sapiens_hsa012000.31464244
86p53 signaling pathway_Homo sapiens_hsa041150.31426174
87One carbon pool by folate_Homo sapiens_hsa006700.30744604
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28278855
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27402881
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27369547
91Selenocompound metabolism_Homo sapiens_hsa004500.26764132
92Regulation of autophagy_Homo sapiens_hsa041400.25242916
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24989620
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22273674
95Glutamatergic synapse_Homo sapiens_hsa047240.21686235
96Starch and sucrose metabolism_Homo sapiens_hsa005000.21397048
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.20691251
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20648758
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20603529
100Dopaminergic synapse_Homo sapiens_hsa047280.19931850

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